{"reference": "Cell Res. 2018 Sep;28(9):897-903.", "alternative_name": "Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor", "entry": "S-0500", "gene_names": "SNCA, NACP, PARK1", "remarks": "cryo-em structure of alpha-synuclein fiber", "secondary_structure": "VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSEEEESCCCCCC&VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ#CCCSSSSCCBSCEEEEEEEEEESCEEECCBSSCCEECCBSCCCEEESSCCCSBCCBSCCCCCC", "chain_id": "", "inchi": "", "amyloid_non_amyloid": "Amyloid", "pmid": "30065316", "ligand_smiles": "", "keyword": "Alpha-synuclein", "peptide_protein_sequence": "chain-ID A: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID B: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID C: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID D: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID E: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID F: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID G: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID H: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID I: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID J: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID K: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ; chain-ID L: VLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQ", "uniprot_ac": "P37840", "protein_name": "Alpha-synuclein", "r_value_free": "", "mutation_s_field": "No", "ligand_mw": "", "pdb_id": "6A6B", "inchi_key": "", "ec_number": "", "pdb_classification": "PROTEIN FIBRIL", "type": "Fibril", "author": "Li, Y., Zhao, C., Luo, F., Liu, Z., Gui, X., Luo, Z., Zhang, X., Li, D., Liu, C., Li, X.", "species": "Homo sapiens", "ligand_id": "", "method": "ELECTRON MICROSCOPY", "ligand_name": "", "global_stoichiometry": "Monomer - A ", "resolution": "3.07", "ligand_formula": "", "length": "63", "ligstr": "", "description": "They determined a fibril structure of full-length Alpha-syn (1-140). They were able to build the fibril structure comprising residues 37-99. The Alpha-syn amyloid fibril structure shows two protofilaments intertwining along an approximate 2 1 screw axis into a left-handed helix. Each protofilament features a Greek key-like topology."}