{"method": "ELECTRON CRYSTALLOGRAPHY", "mutation_s_field": "No", "ec_number": "", "description": "They determined the atomic structures of five segments from protein low-complexity domains associated with membraneless assemblies. Their common structural feature is the stacking of segments into kinked Beta sheets that pair into protofilaments. Unlike steric zippers of amyloid fibrils, the kinked sheets interact weakly through polar atoms and aromatic side chains. STGGYG from low-complexity domain of FUS, residues 77-82.", "ligstr": "TOE:B:C7 H16 O4:164.2:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL:COCCOCCOCCO:InChI=1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3:JLGLQAWTXXGVEM-UHFFFAOYSA-N", "pmid": "29439243", "remarks": "STGGYG from low-complexity domain of FUS, residues 77-82", "amyloid_non_amyloid": "Non-amyloid", "type": "Fibril", "inchi": "InChI=1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3", "resolution": "1.1", "species": "Homo sapiens", "secondary_structure": "STGGYG#CCCCCC&STGGYG#CCCCCC", "chain_id": "B", "gene_names": "", "r_value_free": "0.255", "pdb_id": "6BZP", "reference": "Science. 2018 Feb 9;359(6376):698-701.", "keyword": "RNA-binding protein FUS", "protein_name": "RNA-binding protein FUS", "ligand_formula": "C7 H16 O4", "peptide_protein_sequence": "chain-ID A: STGGYG; chain-ID B: STGGYG", "entry": "S-0508", "length": "6", "uniprot_ac": "P35637", "author": "Hughes, M.P., Sawaya, M.R., Boyer, D.R., Goldschmidt, L., Rodriguez, J.A., Cascio, D., Chong, L., Gonen, T., Eisenberg, D.S.", "ligand_smiles": "COCCOCCOCCO", "ligand_mw": "164.2", "alternative_name": "", "ligand_name": "2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 10-mer - A10", "inchi_key": "JLGLQAWTXXGVEM-UHFFFAOYSA-N", "ligand_id": "TOE"}