{"description": "To uncover the structural origins of two modes of Beta-sheet-rich aggregation (reversible stress granules and irreversible pathogenic amyloid), they have determined ten structures of segments of the LCD of human TDP-43. Six of these segments form steric zippers characteristic of the spines of pathogenic amyloid fibrils; four others form LARKS, the labile amyloid-like interactions characteristic of protein hydrogels and proteins found in membraneless organelles, including stress granules. Segments 300GNNQGSN306, 328AALQSS333 and 370GNNSYS375 all form Class 1 steric zippers in which the Beta-sheets are mated face-to-face with the same edges of the sheet oriented up the fibril.", "pdb_id": "6CB9", "species": "Homo sapiens", "ligand_id": "", "author": "Guenther, E.L., Cao, Q., Trinh, H., Lu, J., Sawaya, M.R., Cascio, D., Boyer, D.R., Rodriguez, J.A., Hughes, M.P., Eisenberg, D.S.", "mutation_s_field": "No", "alternative_name": "", "secondary_structure": "AALQSS#CCCCCC", "length": "6", "method": "X-RAY DIFFRACTION", "inchi": "", "ligand_mw": "", "chain_id": "", "pdb_classification": "PROTEIN FIBRIL", "protein_name": "TDP-43", "remarks": "Segment AALQSS from the low complexity domain of TDP-43, residues 328-333", "type": "Fibril", "keyword": "AALQSS", "uniprot_ac": "", "ec_number": "", "r_value_free": "0.243", "global_stoichiometry": "Homo 10-mer - A10", "amyloid_non_amyloid": "Amyloid", "entry": "S-0521", "pmid": "29786080", "peptide_protein_sequence": "chain-ID A: AALQSS", "ligand_formula": "", "resolution": "1.1", "inchi_key": "", "ligand_smiles": "", "reference": "Nat Struct Mol Biol. 2018 Jun;25(6):463-471.", "ligand_name": "", "ligstr": "", "gene_names": ""}