{"global_stoichiometry": "Homo 10-mer - A10", "ligstr": "", "uniprot_ac": "P37840", "inchi": "", "reference": "Nat Commun. 2018 Sep 6;9(1):3609.", "author": "Li, B., Ge, P., Murray, K.A., Sheth, P., Zhang, M., Nair, G., Sawaya, M.R., Shin, W.S., Boyer, D.R., Ye, S., Eisenberg, D.S., Zhou, Z.H., Jiang, L.", "type": "Fibril", "ligand_id": "", "species": "Homo sapiens", "method": "ELECTRON MICROSCOPY", "keyword": "Alpha-synuclein", "gene_names": "SNCA, NACP, PARK1", "chain_id": "", "ligand_mw": "", "inchi_key": "", "secondary_structure": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEECCCEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEECCCEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEECCCEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEECCCEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEEEEEEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEECCCEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEEEEEEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEECCCEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEEEEEEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCSEEEEEEEEEEEECCCEEEEEEECSSSCEEEECCEECCEESSSCCCSSCEECCCBCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC", "amyloid_non_amyloid": "Amyloid", "length": "140", "remarks": "Alpha Synuclein fibril formed by full length protein - Rod Polymorph", "protein_name": "Alpha-synuclein", "peptide_protein_sequence": "chain-ID A: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID B: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID C: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID D: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID E: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID F: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID G: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID H: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID I: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA; chain-ID J: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA", "ligand_name": "", "ligand_smiles": "", "pdb_id": "6CU7", "ec_number": "", "pdb_classification": "PROTEIN FIBRIL", "mutation_s_field": "No", "ligand_formula": "", "r_value_free": "", "alternative_name": "Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor", "description": "Alpha-Synuclein (aSyn) fibrillar polymorphs have distinct in vitro and in vivo seeding activities, contributing differently to synucleinopathies. They present fibril polymorphs (a rod and a twister) from the full-length recombinant human aSyn and their seeding capacity and cytotoxicity in vitro. Both polymorphs share a kernel structure of a bent Beta-arch, but differ in their inter-protofilament interfaces. Thus, different packing of the same kernel structure gives rise to distinct fibril polymorphs.", "resolution": "3.5", "pmid": "30190461", "entry": "S-0529"}