{"method": "ELECTRON MICROSCOPY", "mutation_s_field": "No", "ec_number": "", "description": "They analyse amyloid fibrils from a mouse and a human patient with systemic AA amyloidosis. The two fibrils differ in fundamental properties, such as presence of right-hand or left-hand twisted cross-Beta sheets and overall fold of the fibril proteins. Yet, both proteins adopt highly similar Beta-arch conformations within the N-terminal 21 residues.", "ligstr": "", "pmid": "30846696", "remarks": "Cryo-EM structure of murine AA amyloid fibril", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "3.0", "species": "Mus musculus", "secondary_structure": "GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSCBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSSBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSCBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSSBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSCBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSSBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSCBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSSBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSCBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSSBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSCBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC&GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR#CEEEEEEESCBCCSSBSCEEESCBSCCEECCCEEEEEESCCSCSEECCCCEEECSEEESCBSCSEEEECCCCCCCCCCCCCCC", "chain_id": "", "gene_names": "Saa2", "r_value_free": "", "pdb_id": "6DSO", "reference": "Nat Commun. 2019 Mar 7;10(1):1104.", "keyword": "Serum amyloid A-2 protein", "protein_name": "Serum amyloid A-2 protein", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID B: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID C: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID D: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID E: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID F: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID G: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID H: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID I: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID J: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID K: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR; chain-ID L: GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANR", "entry": "S-0535", "length": "83", "uniprot_ac": "P05367", "author": "Liberta, F., Loerch, S., Rennegarbe, M., Schierhorn, A., Westermark, P., Westermark, G.T., Hazenberg, B.P.C., Grigorieff, N., Fandrich, M., Schmidt, M.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 12-mer - A12", "inchi_key": "", "ligand_id": ""}