{"reference": "Nat Commun. 2018 Aug 29;9(1):3512.", "alternative_name": "", "entry": "S-0539", "gene_names": "", "remarks": "Crystal Structure of the Amyloid-like IIKVIK Segment from the S. aureus Biofilm-associated PSMalpha1", "secondary_structure": "IIKVIK#CCCCCC", "chain_id": "A", "inchi": "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2", "amyloid_non_amyloid": "Amyloid", "pmid": "30158633", "ligand_smiles": "[O-]S(=O)(=O)[O-]", "keyword": "Phenol-soluble modulin alpha 1 peptide", "peptide_protein_sequence": "chain-ID A: IIKVIK", "uniprot_ac": "H9BRQ5", "protein_name": "Psm alpha-1", "r_value_free": "0.19399999", "mutation_s_field": "No", "ligand_mw": "96.06", "pdb_id": "6FG4", "inchi_key": "QAOWNCQODCNURD-UHFFFAOYSA-L", "ec_number": "", "pdb_classification": "PROTEIN FIBRIL", "type": "Fibril", "author": "Salinas, N., Colletier, J.P., Moshe, A., Landau, M.", "species": "Staphylococcus aureus", "ligand_id": "SO4", "method": "X-RAY DIFFRACTION", "ligand_name": "SULFATE ION", "global_stoichiometry": "Homo 18-mer - A18", "resolution": "1.1", "ligand_formula": "O4 S -2", "length": "6", "ligstr": "SO4:A:O4 S -2:96.06:SULFATE ION:[O-]S(=O)(=O)[O-]:InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2:QAOWNCQODCNURD-UHFFFAOYSA-L", "description": "They show that PSMAlpha1 and PSMAlpha4, involved in biofilm structuring, form canonical cross-Beta amyloid fibrils wherein Beta-sheets tightly mate through steric zipper interfaces, conferring high stability. Contrastingly, a truncated PSMAlpha3 has antibacterial activity, forms reversible fibrils, and reveals two polymorphic and atypical Beta-rich fibril architectures. These architectures are radically different from both the cross-Alpha fibrils formed by full-length PSMAlpha3, and from the canonical cross-Beta fibrils."}