{"method": "ELECTRON MICROSCOPY", "mutation_s_field": "No", "ec_number": "", "description": "The structure of cytotoxic alpha-synuclein fibrils (residues 1-121). Two protofilaments form a polar fibril composed of staggered Beta-strands. The backbone of residues 38 to 95, including the fibril core and the non-amyloid component region.", "ligstr": "", "pmid": "29969391", "remarks": "Structure of alpha-synuclein fibrils", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "3.42", "species": "Homo sapiens", "secondary_structure": "MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCBCCCSSSCCCCSCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCBCCCSSSCCCCSCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCBCCCSSSCCCCSCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCBCCCSSSCCCCSCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCBCCCSSSCCEESCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCBCCCSSSCCCCSCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCEECCSSSCCEESCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCBCCCSSSCCCCSCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCCCEEEEEEEECCBCCCSSSCCEECCCCCEECCSSSCCCCSCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC&MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD#CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCSCCBSCCEEEEEEEEEECCBCCCSSSCCEECCCCCBCCCSSSCCCCSCCCSCCCCCCCCCCCCCCCCCCCCCCCCCCCC", "chain_id": "", "gene_names": "SNCA, NACP, PARK1", "r_value_free": "", "pdb_id": "6H6B", "reference": "Elife. 2018 Jul 3;7. pii: e36402.", "keyword": "Alpha-synuclein", "protein_name": "Alpha-synuclein", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID B: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID C: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID D: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID E: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID F: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID G: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID H: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID I: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD; chain-ID J: MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPD", "entry": "S-0544", "length": "121", "uniprot_ac": "P37840", "author": "Guerrero-Ferreira, R., Taylor, N.M.I., Mona, D., Ringler, P., Lauer, M.E., Riek, R., Britschgi, M., Stahlberg, H.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor", "ligand_name": "", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 10-mer - A10", "inchi_key": "", "ligand_id": ""}