{"method": "ELECTRON MICROSCOPY", "mutation_s_field": "No", "ec_number": "", "description": "The structure of an amyloid fibril formed in vitro from Beta 2 -microglobulin (Beta 2 m), the culprit protein of dialysis-related amyloidosis. The fibril is composed of two identical protofilaments assembled from subunits that do not share Beta 2 m's native tertiary fold, but are formed from similar Beta-strands. The fibrils share motifs with other amyloid fibrils, but also contain unique features including ?-stacking interactions perpendicular to the fibril axis and an intramolecular disulfide that stabilises the subunit fold.", "ligstr": "", "pmid": "30375379", "remarks": "Two protofilament beta-2-microglobulin amyloid fibril", "amyloid_non_amyloid": "Amyloid", "type": "Fibril", "inchi": "", "resolution": "3.97", "species": "Homo sapiens", "secondary_structure": "FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV#CCEEEECCCCSSCEEEEESTTCCEEEEEESCEEESCSEECCCSEEEEECCCBCCEEEEEEEECC&FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV#CCEEEECCCCSSCEEEEESTTCCEEEEEESCEEESCSEECCCSEEEEECCCBCCEEEEEEEECC&FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV#CCEEEECCCCSSCEEEEESTTCCEEEEEESCEEESCSEECCCSEEEEECCCBCCEEEEEEEECC&FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV#CCEEEECCCCSSCEEEEESTTCCEEEEEESCEEESCSEECCCSEEEEECCCBCCEEEEEEEECC&FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV#CCEEEECCCCSSCEEEEESTTCCEEEEEESCEEESCSEECCCSEEEEECCCBCCEEEEEEEECC&FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV#CCEEEECCCCSSCEEEEESTTCCEEEEEESCEEESCSEECCCSEEEEECCCBCCEEEEEEEECC&FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV#CCEEEECCCCSSCEEEEESTTCCEEEEEESCEEESCSEECCCSEEEEECCCBCCEEEEEEEECC&FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV#CCEEEECCCCSSCEEEEESTTCCEEEEEESCEEESCSEECCCSEEEEECCCBCCEEEEEEEECC", "chain_id": "", "gene_names": "B2M, CDABP0092, HDCMA22P", "r_value_free": "", "pdb_id": "6GK3", "reference": "Nat Commun. 2018 Oct 30;9(1):4517.", "keyword": "Beta-2-microglobulin", "protein_name": "Beta-2-microglobulin", "ligand_formula": "", "peptide_protein_sequence": "chain-ID A: FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV; chain-ID B: FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV; chain-ID C: FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV; chain-ID D: FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV; chain-ID E: FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV; chain-ID F: FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV; chain-ID G: FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV; chain-ID H: FLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHV", "entry": "S-0550", "length": "64", "uniprot_ac": "P61769", "author": "Iadanza, M.G., Silvers, R., Boardman, J., Smith, H.I., Karamanos, T.K., Debelouchina, G.T., Su, Y., Griffin, R.G., Ranson, N.A., Radford, S.E.", "ligand_smiles": "", "ligand_mw": "", "alternative_name": "", "ligand_name": "", "pdb_classification": "PROTEIN FIBRIL", "global_stoichiometry": "Homo 8-mer - A8 ", "inchi_key": "", "ligand_id": ""}