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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 571 to 600 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0571
LATVYQ
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
V43Q
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0572
LATVYR
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
V43R
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0573
LATVYS
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
V43S
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0574
LATVYT
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
V43T
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0575
LATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
No
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0576
LATVYW
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
V43W
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0577
LATVYY
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
V43Y
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0578
LATWYV
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
V41W
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0579
LATYYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
V41Y
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0580
LAVAGD
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0581
LAVLFL
6
Amyloid
Apolipoprotein A-I (ApoA-I)
P02647
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0582
LAVVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40V
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0583
LAWVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40W
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0584
LAYVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40Y
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0585
LCTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39C
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0586
LDGFSR
6
Non-amyloid
von Willebrand factor (vWF)
P04275
S1285F
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0587
LDGSSR
6
Non-amyloid
von Willebrand factor (vWF)
P04275
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0588
LDQWNG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0589
LDTVYV
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39D
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0590
LEFWLQ
6
Amyloid
4F2 cell-surface antigen heavy chain (4F2hc)
P08195
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0591
LETVYV
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39E
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0592
LFMFND
6
Non-amyloid
Alpha-galactosidase A
P06280
S297F
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0593
LFMSND
6
Non-amyloid
Alpha-galactosidase A
P06280
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0594
LFNNST
6
Non-amyloid
Nucleoporin NSP1
P14907
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0595
LFTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39F
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0596
LGNNSN
6
Non-amyloid
[PIN+] prion protein RNQ1
P25367
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0597
LGTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39G
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0598
LHTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39H
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0599
LIAGFN
6
Non-amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0600
LIFLIV
6
Amyloid
Major prion protein (PrP)
P04156
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
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Entry: P-0571 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0571
Peptide:
LATVYQ
Length:
6
Classification:
non-amyloid
Mutation(s):
V43Q
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.2
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.1
Area of the profile Above Threshold (AGGRESCAN):
1.87
Best Energy Score (PASTA 2.0):
-2.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0572 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0572
Peptide:
LATVYR
Length:
6
Classification:
non-amyloid
Mutation(s):
V43R
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.0
Area of the profile Above Threshold (AGGRESCAN):
1.87
Best Energy Score (PASTA 2.0):
-2.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0573 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0573
Peptide:
LATVYS
Length:
6
Classification:
non-amyloid
Mutation(s):
V43S
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.5
Area of the profile Above Threshold (AGGRESCAN):
2.43
Best Energy Score (PASTA 2.0):
-2.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0574 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0574
Peptide:
LATVYT
Length:
6
Classification:
non-amyloid
Mutation(s):
V43T
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
37.8
Area of the profile Above Threshold (AGGRESCAN):
2.52
Best Energy Score (PASTA 2.0):
-3.22
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0575 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0575
Peptide:
LATVYV
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.78
Tango:
4.63
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
55.4
Area of the profile Above Threshold (AGGRESCAN):
3.57
Best Energy Score (PASTA 2.0):
-4.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0576 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0576
Peptide:
LATVYW
Length:
6
Classification:
amyloid
Mutation(s):
V43W
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.72
Tango:
3.56
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
49.8
Area of the profile Above Threshold (AGGRESCAN):
3.23
Best Energy Score (PASTA 2.0):
-3.68
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0577 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0577
Peptide:
LATVYY
Length:
6
Classification:
amyloid
Mutation(s):
V43Y
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.66
Tango:
1.38
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
51.0
Area of the profile Above Threshold (AGGRESCAN):
3.31
Best Energy Score (PASTA 2.0):
-3.21
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0578 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0578
Peptide:
LATWYV
Length:
6
Classification:
non-amyloid
Mutation(s):
V41W
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.72
Tango:
3.55
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
44.2
Area of the profile Above Threshold (AGGRESCAN):
2.84
Best Energy Score (PASTA 2.0):
-3.68
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0579 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0579
Peptide:
LATYYV
Length:
6
Classification:
amyloid
Mutation(s):
V41Y
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.66
Tango:
1.38
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.7
Area of the profile Above Threshold (AGGRESCAN):
3.0
Best Energy Score (PASTA 2.0):
-3.21
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0580 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0580
Peptide:
LAVAGD
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.27
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.9
Area of the profile Above Threshold (AGGRESCAN):
1.18
Best Energy Score (PASTA 2.0):
-1.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0581 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0581
Peptide:
LAVLFL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
8-13
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.03
Tango:
68.91
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
91.9
Area of the profile Above Threshold (AGGRESCAN):
5.92
Best Energy Score (PASTA 2.0):
-4.66
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0582 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0582
Peptide:
LAVVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40V
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.06
Tango:
81.94
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
90.4
Area of the profile Above Threshold (AGGRESCAN):
5.85
Best Energy Score (PASTA 2.0):
-6.7
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0583 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0583
Peptide:
LAWVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40W
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.02
Tango:
64.95
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
79.3
Area of the profile Above Threshold (AGGRESCAN):
5.12
Best Energy Score (PASTA 2.0):
-5.6
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0584 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0584
Peptide:
LAYVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40Y
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
0.98
Tango:
26.66
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
81.7
Area of the profile Above Threshold (AGGRESCAN):
5.28
Best Energy Score (PASTA 2.0):
-5.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0585 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0585
Peptide:
LCTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39C
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.06
Tango:
1.25
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
63.9
Area of the profile Above Threshold (AGGRESCAN):
4.14
Best Energy Score (PASTA 2.0):
-5.35
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0586 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0586
Peptide:
LDGFSR
Length:
6
Classification:
Non-amyloid
Mutation(s):
S1285F
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1282-1287
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.7
Area of the profile Above Threshold (AGGRESCAN):
0.11
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0587 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0587
Peptide:
LDGSSR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1282-1287
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
16.67
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.15
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0588 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0588
Peptide:
LDQWNG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
103-108
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-55.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.62
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0589 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0589
Peptide:
LDTVYV
Length:
6
Classification:
non-amyloid
Mutation(s):
A39D
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
31.4
Area of the profile Above Threshold (AGGRESCAN):
2.22
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0590 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
E
L
Q
P
P
E
A
S
I
A
V
V
S
I
P
R
Q
L
P
G
S
H
S
E
A
G
V
Q
G
L
S
A
G
D
D
S
E
L
G
S
H
C
V
A
Q
T
G
L
E
L
L
A
S
G
D
P
L
P
S
60
61
A
S
Q
N
A
E
M
I
E
T
G
S
D
C
V
T
Q
A
G
L
Q
L
L
A
S
S
D
P
P
A
L
A
S
K
N
A
E
V
T
G
T
M
S
Q
D
T
E
V
D
M
K
E
V
E
L
N
E
L
E
P
120
121
E
K
Q
P
M
N
A
A
S
G
A
A
M
S
L
A
G
A
E
K
N
G
L
V
K
I
K
V
A
E
D
E
A
E
A
A
A
A
A
K
F
T
G
L
S
K
E
E
L
L
K
V
A
G
S
P
G
W
V
R
180
181
T
R
W
A
L
L
L
L
F
W
L
G
W
L
G
M
L
A
G
A
V
V
I
I
V
R
A
P
R
C
R
E
L
P
A
Q
K
W
W
H
T
G
A
L
Y
R
I
G
D
L
Q
A
F
Q
G
H
G
A
G
N
240
241
L
A
G
L
K
G
R
L
D
Y
L
S
S
L
K
V
K
G
L
V
L
G
P
I
H
K
N
Q
K
D
D
V
A
Q
T
D
L
L
Q
I
D
P
N
F
G
S
K
E
D
F
D
S
L
L
Q
S
A
K
K
K
300
301
S
I
R
V
I
L
D
L
T
P
N
Y
R
G
E
N
S
W
F
S
T
Q
V
D
T
V
A
T
K
V
K
D
A
L
E
F
W
L
Q
A
G
V
D
G
F
Q
V
R
D
I
E
N
L
K
D
A
S
S
F
L
360
361
A
E
W
Q
N
I
T
K
G
F
S
E
D
R
L
L
I
A
G
T
N
S
S
D
L
Q
Q
I
L
S
L
L
E
S
N
K
D
L
L
L
T
S
S
Y
L
S
D
S
G
S
T
G
E
H
T
K
S
L
V
T
420
421
Q
Y
L
N
A
T
G
N
R
W
C
S
W
S
L
S
Q
A
R
L
L
T
S
F
L
P
A
Q
L
L
R
L
Y
Q
L
M
L
F
T
L
P
G
T
P
V
F
S
Y
G
D
E
I
G
L
D
A
A
A
L
P
480
481
G
Q
P
M
E
A
P
V
M
L
W
D
E
S
S
F
P
D
I
P
G
A
V
S
A
N
M
T
V
K
G
Q
S
E
D
P
G
S
L
L
S
L
F
R
R
L
S
D
Q
R
S
K
E
R
S
L
L
H
G
D
540
541
F
H
A
F
S
A
G
P
G
L
F
S
Y
I
R
H
W
D
Q
N
E
R
F
L
V
V
L
N
F
G
D
V
G
L
S
A
G
L
Q
A
S
D
L
P
A
S
A
S
L
P
A
K
A
D
L
L
L
S
T
Q
600
601
P
G
R
E
E
G
S
P
L
E
L
E
R
L
K
L
E
P
H
E
G
L
L
L
R
F
P
Y
A
A
630
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0590
Peptide:
LEFWLQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P08195
UniProt Name:
4F2_HUMAN
Protein Name:
4F2 cell-surface antigen heavy chain (4F2hc)
Position:
334-339
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.88
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.8
Area of the profile Above Threshold (AGGRESCAN):
2.57
Best Energy Score (PASTA 2.0):
-1.14
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0591 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0591
Peptide:
LETVYV
Length:
6
Classification:
non-amyloid
Mutation(s):
A39E
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.7
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
37.0
Area of the profile Above Threshold (AGGRESCAN):
2.39
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0592 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
R
N
P
E
L
H
L
G
C
A
L
A
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
A
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
W
E
R
F
M
C
N
L
D
C
Q
E
E
P
60
61
D
S
C
I
S
E
K
L
F
M
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
C
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
P
Q
R
F
P
H
G
I
R
Q
L
120
121
A
N
Y
V
H
S
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
A
D
W
G
V
D
L
L
K
F
D
G
C
Y
C
D
S
L
E
N
L
180
181
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
M
W
P
F
Q
K
P
N
Y
T
E
I
R
Q
Y
C
N
H
W
R
N
F
A
D
I
D
D
S
W
K
S
I
K
240
241
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
D
V
A
G
P
G
G
W
N
D
P
D
M
L
V
I
G
N
F
G
L
S
W
N
Q
Q
V
T
Q
M
A
L
W
A
I
M
A
A
P
L
F
M
S
N
D
L
300
301
R
H
I
S
P
Q
A
K
A
L
L
Q
D
K
D
V
I
A
I
N
Q
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
F
E
V
W
E
R
P
L
S
G
L
A
W
A
V
A
M
I
N
R
Q
E
I
G
360
361
G
P
R
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
N
P
A
C
F
I
T
Q
L
L
P
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
T
420
421
M
Q
M
S
L
K
D
L
L
429
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0592
Peptide:
LFMFND
Length:
6
Classification:
Non-amyloid
Mutation(s):
S297F
Structure(s):
No structures
Protein Information
UniProt ID:
P06280
UniProt Name:
AGAL_HUMAN
Protein Name:
Alpha-galactosidase A
Position:
294-299
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.34
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.7
Area of the profile Above Threshold (AGGRESCAN):
3.33
Best Energy Score (PASTA 2.0):
-2.71
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0593 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
R
N
P
E
L
H
L
G
C
A
L
A
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
A
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
W
E
R
F
M
C
N
L
D
C
Q
E
E
P
60
61
D
S
C
I
S
E
K
L
F
M
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
C
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
P
Q
R
F
P
H
G
I
R
Q
L
120
121
A
N
Y
V
H
S
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
A
D
W
G
V
D
L
L
K
F
D
G
C
Y
C
D
S
L
E
N
L
180
181
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
M
W
P
F
Q
K
P
N
Y
T
E
I
R
Q
Y
C
N
H
W
R
N
F
A
D
I
D
D
S
W
K
S
I
K
240
241
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
D
V
A
G
P
G
G
W
N
D
P
D
M
L
V
I
G
N
F
G
L
S
W
N
Q
Q
V
T
Q
M
A
L
W
A
I
M
A
A
P
L
F
M
S
N
D
L
300
301
R
H
I
S
P
Q
A
K
A
L
L
Q
D
K
D
V
I
A
I
N
Q
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
F
E
V
W
E
R
P
L
S
G
L
A
W
A
V
A
M
I
N
R
Q
E
I
G
360
361
G
P
R
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
N
P
A
C
F
I
T
Q
L
L
P
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
T
420
421
M
Q
M
S
L
K
D
L
L
429
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0593
Peptide:
LFMSND
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06280
UniProt Name:
AGAL_HUMAN
Protein Name:
Alpha-galactosidase A
Position:
294-299
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.3
Area of the profile Above Threshold (AGGRESCAN):
1.62
Best Energy Score (PASTA 2.0):
-1.16
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0594 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
F
N
T
P
Q
Q
N
K
T
P
F
S
F
G
T
A
N
N
N
S
N
T
T
N
Q
N
S
S
T
G
A
G
A
F
G
T
G
Q
S
T
F
G
F
N
N
S
A
P
N
N
T
N
N
A
N
S
S
I
60
61
T
P
A
F
G
S
N
N
T
G
N
T
A
F
G
N
S
N
P
T
S
N
V
F
G
S
N
N
S
T
T
N
T
F
G
S
N
S
A
G
T
S
L
F
G
S
S
S
A
Q
Q
T
K
S
N
G
T
A
G
G
120
121
N
T
F
G
S
S
S
L
F
N
N
S
T
N
S
N
T
T
K
P
A
F
G
G
L
N
F
G
G
G
N
N
T
T
P
S
S
T
G
N
A
N
T
S
N
N
L
F
G
A
T
A
N
A
N
K
P
A
F
S
180
181
F
G
A
T
T
N
D
D
K
K
T
E
P
D
K
P
A
F
S
F
N
S
S
V
G
N
K
T
D
A
Q
A
P
T
T
G
F
S
F
G
S
Q
L
G
G
N
K
T
V
N
E
A
A
K
P
S
L
S
F
G
240
241
S
G
S
A
G
A
N
P
A
G
A
S
Q
P
E
P
T
T
N
E
P
A
K
P
A
L
S
F
G
T
A
T
S
D
N
K
T
T
N
T
T
P
S
F
S
F
G
A
K
S
D
E
N
K
A
G
A
T
S
K
300
301
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
360
361
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
P
D
E
N
K
A
S
A
T
S
K
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
420
421
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
S
480
481
D
E
K
K
D
S
D
S
S
K
P
A
F
S
F
G
T
K
S
N
E
K
K
D
S
G
S
S
K
P
A
F
S
F
G
A
K
P
D
E
K
K
N
D
E
V
S
K
P
A
F
S
F
G
A
K
A
N
E
K
540
541
K
E
S
D
E
S
K
S
A
F
S
F
G
S
K
P
T
G
K
E
E
G
D
G
A
K
A
A
I
S
F
G
A
K
P
E
E
Q
K
S
S
D
T
S
K
P
A
F
T
F
G
A
Q
K
D
N
E
K
K
T
600
601
E
E
S
S
T
G
K
S
T
A
D
V
K
S
S
D
S
L
K
L
N
S
K
P
V
E
L
K
P
V
S
L
D
N
K
T
L
D
D
L
V
T
K
W
T
N
Q
L
T
E
S
A
S
H
F
E
Q
Y
T
K
660
661
K
I
N
S
W
D
Q
V
L
V
K
G
G
E
Q
I
S
Q
L
Y
S
D
A
V
M
A
E
H
S
Q
N
K
I
D
Q
S
L
Q
Y
I
E
R
Q
Q
D
E
L
E
N
F
L
D
N
F
E
T
K
T
E
A
720
721
L
L
S
D
V
V
S
T
S
S
G
A
A
A
N
N
N
D
Q
K
R
Q
Q
A
Y
K
T
A
Q
T
L
D
E
N
L
N
S
L
S
S
N
L
S
S
L
I
V
E
I
N
N
V
S
N
T
F
N
K
T
T
780
781
N
I
D
I
N
N
E
D
E
N
I
Q
L
I
K
I
L
N
S
H
F
D
A
L
R
S
L
D
D
N
S
T
S
L
E
K
Q
I
N
S
I
K
K
823
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0594
Peptide:
LFNNST
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14907
UniProt Name:
NSP1_YEAST
Protein Name:
Nucleoporin NSP1
Position:
128-133
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.5
Area of the profile Above Threshold (AGGRESCAN):
0.07
Best Energy Score (PASTA 2.0):
-1.6
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0595 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0595
Peptide:
LFTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39F
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.96
Tango:
64.35
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
79.2
Area of the profile Above Threshold (AGGRESCAN):
5.18
Best Energy Score (PASTA 2.0):
-6.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0596 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
T
D
K
L
I
S
E
A
E
S
H
F
S
Q
G
N
H
A
E
A
V
A
K
L
T
S
A
A
Q
S
N
P
N
D
E
Q
M
S
T
I
E
S
L
I
Q
K
I
A
G
Y
V
M
D
N
R
S
G
G
60
61
S
D
A
S
Q
D
R
A
A
G
G
G
S
S
F
M
N
T
L
M
A
D
S
K
G
S
S
Q
T
Q
L
G
K
L
A
L
L
A
T
V
M
T
H
S
S
N
K
G
S
S
N
R
G
F
D
V
G
T
V
M
120
121
S
M
L
S
G
S
G
G
G
S
Q
S
M
G
A
S
G
L
A
A
L
A
S
Q
F
F
K
S
G
N
N
S
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
S
F
T
A
L
A
S
L
180
181
A
S
S
F
M
N
S
N
N
N
N
Q
Q
G
Q
N
Q
S
S
G
G
S
S
F
G
A
L
A
S
M
A
S
S
F
M
H
S
N
N
N
Q
N
S
N
N
S
Q
Q
G
Y
N
Q
S
Y
Q
N
G
N
Q
N
240
241
S
Q
G
Y
N
N
Q
Q
Y
Q
G
G
N
G
G
Y
Q
Q
Q
Q
G
Q
S
G
G
A
F
S
S
L
A
S
M
A
Q
S
Y
L
G
G
G
Q
T
Q
S
N
Q
Q
Q
Y
N
Q
Q
G
Q
N
N
Q
Q
Q
300
301
Y
Q
Q
Q
G
Q
N
Y
Q
H
Q
Q
Q
G
Q
Q
Q
Q
Q
G
H
S
S
S
F
S
A
L
A
S
M
A
S
S
Y
L
G
N
N
S
N
S
N
S
S
Y
G
G
Q
Q
Q
A
N
E
Y
G
R
P
Q
Q
360
361
N
G
Q
Q
Q
S
N
E
Y
G
R
P
Q
Y
G
G
N
Q
N
S
N
G
Q
H
E
S
F
N
F
S
G
N
F
S
Q
Q
N
N
N
G
N
Q
N
R
Y
405
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0596
Peptide:
LGNNSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P25367
UniProt Name:
RNQ1_YEAST
Protein Name:
[PIN+] prion protein RNQ1
Position:
336-341
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-80.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0597 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0597
Peptide:
LGTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39G
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.66
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
48.7
Area of the profile Above Threshold (AGGRESCAN):
3.12
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0598 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0598
Peptide:
LHTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39H
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.78
Tango:
0.74
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
42.1
Area of the profile Above Threshold (AGGRESCAN):
2.67
Best Energy Score (PASTA 2.0):
-5.2
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0599 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0599
Peptide:
LIAGFN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
19.0
Area of the profile Above Threshold (AGGRESCAN):
1.81
Best Energy Score (PASTA 2.0):
-1.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0600 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0600
Peptide:
LIFLIV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
247-252
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.08
Tango:
465.21
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
122.9
Area of the profile Above Threshold (AGGRESCAN):
7.98
Best Energy Score (PASTA 2.0):
-8.35
Aggregate Orientation (PASTA 2.0):
Parallel
