PRA-MutPred Protein-RNA complex Binding Affinity change Prediction

PRA-MutPred

This server predicts protein-RNA binding affinity change upon mutation using sequence and structure-based features of protein-RNA complexes. We found that number of atomic contacts between the RNA and protein,contact potentials and accessibility of the residues are important to understand the binding affinity. PRA-MutPred shows a correlation of 0.85 and a mean absolute error(MAE) of 0.59 in Self-consistency, correlation of 0.75 and a MAE of 0.84 kcal/mol in jack-knife test.

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Representation of the effect of mutation in protein-nucleic acid complexes