Database for binding affinities of protein-nucleic acid complexes and their mutants


ProNAB, a database on binding affinity of protein-nucleic acid complexes. ProNAB, which contains 20 219 entries on dissociation constant (Kd), binding free energy change (ΔG), experimental conditions, sequence, structure and literature information. Additional features include the options to search, display, visualization, download and upload the data.

Users can search for a specific protein, Nucleic acid, affinity values (Kd), a range of ΔG values, ΔΔG values for a specific mutation, secondary structure and accessible surface area (ASA). Please check our tutorial for help on searching the database. Have questions? Please see our FAQs page. If you would like to access the entire dataset, please contact us. Thank you for visiting ProNAB.

What's New

  •  Feb 2023: Updated the database with 129 binding affinity data from recent literature. 
  •  Jan 2023: Updated the Download page. 
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