Protein Bioinformatics Lab

What's New

09/02/2026
  • Published an article “Herpes Simplex Virus Glycoprotein D Associated with Aβ1-42 Tetramers Mediates Neurotoxicity by Perturbing Neuronal Membrane Integrity: A Molecular Dynamics Simulation”, S. Boopathi*, R. Garduno-Juarez and M. Michael Gromiha* in ACS Chemical Neuroscience.
02/02/2026
  • Prof. Michael Gromiha delivered a Keynote leture at the "3rd International Conference on Emerging Concepts in Biotechnological Innovations", SRM Institute of Technology, Chennai.
28/01/2026
  • Prof. M. Michael Gromiha delivered an Invited talk at the “International conference titled "International Conference on AI for Genomics and Drug Discovery", Bhartathiar University, Coimbatore.
24/01/2026
  • Organized the 3rd Protein Bioinformatics Lab symposium on "From Molecular Interactions to Disease Mechanisms: Computational Perspectives" on 24th Jan 2026.
11/01/2026
  • Prof. M. Michael Gromiha delivered the Margaret Dayhoff Keynote lecture at the “National Conference on Emerging Trends in Structural Biophysics”, NIT Warangal.
01/01/2026
  • Published an article “Integrating sequence, structure, and graph-based features for elucidating the stability of thermophilic proteins.”, P.R. Reddy, F. Ridha and M Michael Gromiha* in Journal of Molecular Biology.

25/12/2025
  • Published an article “DRLiPS: A Novel Method for Prediction of Druggable RNA-Small Molecule Binding Pockets Using Machine Learning.”, S.R. Krishnan, A. Roy, L. Wong and M. Michael Gromiha* in Nucleic Acids Research.
18/12/2025
  • Prof. M. Michael Gromiha delivered a Keynote lecture at the “3rd International Conference cum Workshop on “Recent Trends in Structural Bioinformatics and Computer Aided Drug Design”, Alagappa University, Karaikudi.
10/12/2025
  • Prof. M. Michael Gromiha received the "Outstanding Contribution Award" from the Asia-Pacific Biotechnology and Drug discovery (BT & D2) Alliance (APBA), Taiwan for excellence in research and innovation.
09/12/2025
  • Professor Giulia Palermo from University of California Riverside, USA visited Protein Bioinformatics Lab and interacted with students
05/12/2025
  • Professor M. Michael Gromiha Chaired a session at the CARE conference 2025, IIT Madras.
04/12/2025
  • Professor Shankar Subramanium from University of California San Diego, USA visited Protein Bioinformatics Lab and interacted with students.
03/12/2025
  • Professor Naoki SUGIMOTO from Konan University, Japan visited Protein Bioinformatics Lab and interacted with students.
  • Professor Helmut Grubmüller from the Max Planck Institute for Multidisciplinary Sciences Göttingen, Germany visited Protein Bioinformatics Lab and interacted with students.
29/11/2025
  • Prof. M. Michael Gromiha delivered a Keynote lecture at the “3rd APBA International Conference on Taiwan-New Southbound Countries: Bridge and Create Opportunity of Healthcare, Sustainability and Entrepreneurship Development of Medicine by Intelligence and Preventative Medicine Strategies”, National Cheng Kung University, Taiwan.
7/11/2025
  • Published an article “Structural and functional effects of disease mutations in the interface of human membrane protein complexes”, F. Ridha, D. Frishman and M. Michael Gromiha* in International Journal of Biological Macromolecules.
6/11/2025
  • Prof. M. Michael Gromiha delivered an invited guest lecture at National University of Singapore, Singapore.
1/11/2025
  • Published an article “Blind prediction of complex water and ion networks around RNA in CASP16.”, R.C. Kretsch, E. Posani, E.F. Baulin, J.M. Bujnicki, G. Bussi, T.E. Cheatham, S-J. Chen, A. Elofsson, M.A. Farsani, O.N. Fisher, M. Michael Gromiha, A. Gupta, M. Hamada, K. Harini, G. Hu, D. Huang, J. Iwakiri, A. Jain, Y. Kagaya, D. Kihara, S. Kmiecik, S.R. Krishnan, I. Kurisaki, O. Languin-Cattoën, J. Li, S. Li, K. Malekzadeh, T. Nakamura, W. Ni, C. Nithin, M. Z. Palo, J.H. Park, S. P. Pilla, S. Poblete, F. Pucci, P. Punuru, A. Saha, K. Sato , A. Srivastava, G. Terashi, E. Tugolukova, J. Verburgt, Q. Wuyun, G.H. Zerze, K. Zhang, S. Zhang, W. Zheng, Y. Zhou, W. Chiu, D.A. Case, R. Das in Proteins : Structure, Function and Bioinformatics.
29/10/2025
  • Prof. Michael Gromiha delivered a keynote lecture at the "Global Summit on Innovative Drug Design, Discovery, and Translational Research", Pondicherry University, Pondicherry.
07/10/2025
  • Published a review “Binding affinity prediction of membrane protein-protein complexes using MPA-Pred”, F. Ridha and M. Michael Gromiha* in Methods in Molecular Biology.
05/10/2025
  • We congratulate Sowmya RK for receiving the Institute Research Award
20/09/2025
  • Prof. M. Michael Gromiha delivered a Keynote lecture at the “National Conference on Molecules to medicine: applications to drug design and delivery”, Mepco Schlenk Engineering College, Sivakasi.
16/09/2025
  • Prof. M. Michael Gromiha delivered an invited lecture at Vel-Tech High-Tech Engineering College, Chennai.
05/09/2025
  • Published a review, "Integrative Computational Approaches for Understanding Drug Resistance in HIV-1 Protease Subtype C", S. Venkatachalam, N. Muralidharan, R. Pandian, Y. Sayed and M. Michael Gromiha* in Viruses.
02/09/2025
  • We congratulate Dr. Fathima Ridha for successfully defending her thesis on "Development of computational resources for understanding and predicting the binding affinities of membrane protein-protein complexes and their mutations".
14/08/2025
  • Prof. Michael Gromiha delivered an invited talk at the “National Workshop on Computational and structural biology in drug and vaccine development”, JSS Academy of Higher Education and Research, Ooty
13/08/2025
  • Dr. Fabian Davamani from International Medical University Malaysia visisted our lab and interacted with students.
11/08/2025
  • We welcome Ms. Krithika S. to Protein Bioinformatics Lab as a MS scholar
10/08/2025
  • Conducted NPTEL workshop on WEKA: Exploring machine learning for healthcare-batch 4
02/08/2025
  • Published a review, "Progress on the development of prediction tools for detecting disease causing mutations in proteins”, M. Michael Gromiha*, M. Pandey, A. Kulandaisamy, D. Sharma and F. Ridha in Computers in Biology and Medicine.
02/08/2025
  • We congratulate sowmya krishnan for receiving 2nd prize in oral presentation for her talk on RNA-small molecule interactions at BIOMERS 2025 Annual Research Scholar Symposium organized by Department of Biotechnology IIT Madras.
30/07/2025
  • Dr. Arijit Roy from TCS Research visited our lab and delivered a talk.
30/07/2025
  • Sowmya presented her PhD seminar II on "Exploring the potential of RNAs to act as druggable targets in disease conditions through computational analysis of RNA-small molecule interactions."
24/07/2025
22/07/2025
  • Published a letter to the Editor, Comment on "Contrastive pre-training and 3D Convolution Neural Network for RNA and small molecule binding affinity prediction”, S.R. Krishnan, A. Roy and M. Michael Gromiha* in Bioinformatics.
18/07/2025
  • We congratulate Vaishnavi, for receiving Young Writer Award in the Non-Fiction category for her book "அறிவதுவே" at the Coimbatore Book Festival, organized by CODISSIA - COIMBATORE DISTRICT SMALL INDUSTRIES ASSOCIATION.
11/07/2025
  • Prof. Michael Gromiha delivered an invited talk at the “Physiology Conference on Artificial intelligence: application in medical education and clinical practice”, Sharda University, July 2025
09/07/2025
  • Sankaran presneted his Research Proposal Seminar on "AI-based Computational Pipeline to Accelerate Peptide Drug Design"
07/07/2025
  • Preethi presented her Research Proposal Seminar on "Computational Analysis and Development of AI-based Models for Gastric Cancer using Multimodal Data from Indian Population".
03/07/2025
  • Prof. Michael Gromiha delivered an invited talk at the “Faculty Development Program on Cutting-Edge Innovations in Protein Science: From Bioprocessing to Computational Modeling”, NIT Andra Pradesh
02/07/2025
17/06/2025
  • Prof. Michael Gromiha delivered an invited guest lecture at IIT Guwahati
15/06/2025
  • Published an article "Structural implications of HIV-1 protease subtype C bound to darunavir: A molecular dynamics study", S.V. Sankaran, S.R. Krishnan, R. Pandian, Y. Sayed and M. Michael Gromiha* in PROTEINS: Structure, Function and Bioinformatics.
13/06/2025
  • Dr. N.R. Siva Shanmugam from University of Nebraska-Lincoln (Protein Bioinformatics Lab alumnus) visited our lab and delivered a talk.
25/05/2025
  • Published a review “Illustrative features and utilities of MPAD: Thermodynamic database for membrane protein-protein complexes”, F. Ridha and M. Michael Gromiha* in Methods in Molecular Biology.
07/05/2025
  • Published an article "TMB Stab-pred: Predicting the stability of transmembrane β-barrel proteins using their sequence and structural signatures”, P. R. Reddy, A. Kulandaisamy and M. Michael Gromiha* in Biochim. Biophys. Acta: Proteins and Proteomics.
26/04/2025
  • Fathima Ridha presented a flash talk and a poster on “Unveiling the impact of mutations on binding affinity in membrane protein complexes: A novel computational approach” at the RECOMB 2025, held in Seoul, South Korea.
20/04/2025
  • Published an invited review “Protein structural bioinformatics: an overview”, M. Michael Gromiha* , F. Ridha and S. Selvaraj in Encyclopedia of Bioinformatics and Computational Biology.
11/04/2025
  • We congratulate Fathima Ridha for receiving the Institute Research Award
10/04/2025
  • Published an article "PRA-MutPred: Predicting the effect of point mutations in protein-RNA complexes using structural features", K. Harini, M. Sekijima and M. Michael Gromiha* in Journal of Chemical Information and Modeling.
01/04/2025
  • Prof. Michael Gromiha delivered a Keynote talk at the “Weihenstephan Bioinformatics Symposium” at Technical University of Munich, Germany.
31/03/2025
  • Published an article "P21-activated kinase 1 (PAK1) modulates therapeutic response to ionizing radiation in head and neck squamous cell carcinoma cells", S. Rajendran, R.P. Surabhi, A.S. Kumar, P. Gopinath, V. Kanakaveti, G. Shanmugasundaram, M. Michael Gromiha , S.K. Rayala and G. Venkatraman in Molecular Carcinogenesis.
27/03/2025
  • Prof. Michael Gromiha delivered an invited talk at National Cancer Institute, Copenhagen, Denmark.
17/03/2025
  • Published an article " Investigating local sequence-structural attributes of light chain variable domains (VLs) in amyloidosis", P. Rawat, R. Prabakaran, D. Sharma, V. Mandala, V. Greiff, S. Kumar, M Michael Gromiha in PROTEINS: Structure, Function and Bioinformatics
12/03/2025
  • We welcome Mrs. H. M. Nisha to Protein Bioinformatics Lab as a Ph.D scholar.
01/03/2025
  • We welcome Ms. S. Vaishnavi to Protein Bioinformatics Lab as a Ph.D scholar.
01/03/2025
  • We congratulate Fathima Ridha on receiving the Best Flash Talk Award at the Horizons in Structural and Computational Biology (HSCB 2025) conference, held at IIT Hyderabad.
28/02/2025
  • Fathima Ridha presented a flash talk and a poster on "Investigating binding affinity and mutational effects in membrane protein complexes: A computational perspective" at the Horizons in Structural and Computational Biology (HSCB 2025) conference, held at IIT Hyderabad
28/02/2025
  • Prof. Michael Gromiha delivered a Keynote lecture at the “Horizons in structural and computational biology” at IIT Hyderabad.
25/02/2025
  • Prof. Michael Gromiha delivered an invited talk at the "National Conference on “Drug Discovery 2025: Emerging Trends and Future Perspectives” at Jamia Millia Islamia, New Delhi
22/02/2025
  • Published an article “ZFP-CanPred: Predicting the Effect of Mutations in Zinc-Finger Proteins in Cancers Using Protein Language Models”, A. Phogat, S.R. Krishnan, M. Pandey and M. Michael Gromiha* in Methods.
20/02/2025
  • Dr. Suresh from Technical University of Denmark visited Protein Bioinformatics Lab.
18/02/2025
  • Prof. Dmitrij Frishman visited Protein Bioinformatics Lab and delivered an invited talk on 18th February 2025.
09/02/2025
  • Conducted NPTEL workshop on WEKA: Exploring machine learning for healthcare - batch 3.
01/02/2025
  • Published a review “Role of HSP90 in Type2 Diabetes mellitus and its association with Liver diseases.”, V. Nithyasree, P. Magdalene, P.K. Praveen Kumar, J. Preethi and M. Michael Gromiha in Molecular Biotechnology.
17/01/2025
  • Prof. Michael Gromiha delivered a keynote lecture at the "15th International Conference on Biosciences, Biochemistry and Bioinformatics", at Chulalongkorn University, Bangkok, Thailand.
08/01/2025
  • We congratulate Dr. Divya Sharma for successfully defending her thesis on "Computational investigation of binding affinity, mutational effects and therapeutics of SARS-CoV-2 neutralizing antibodies".
05/01/2025
  • We congratulate Sowmya for receiving the Research Excellence Award from IIT Madras.
01/01/2025
  • Published a review "Protein-nucleic acid complexes: docking and binding affinity", M. Michael Gromiha and k. Harini in Current Opinion in structural Biology.

25/12/2024
  • Published an article "MPA-MutPred: A novel strategy for accurately predicting the binding affinity change upon mutation in membrane protein complexes.", F. Ridha and M. Michael Gromiha* in Briefings in Bioinformatics.
19/12/2024
  • Prof. Michael Gromiha delivered an invited talk at the “Faculty Development Program on "Computational Genomics: Theory and Application”, NIT Warangal.
17/12/2024
  • Mr. Sankaran delivered an oral presentation at the TAC-MI International Forum 2024, Institute of Science Tokyo, Japan
17/12/2024
  • Prof. M. Michael Gromiha delivered a Keynote lecture at the TAC-MI International Forum 2024, Institute of Science Tokyo, Japan.​​​
10/12/2024
  • Prof. Michael Gromiha delivered a Keynote lecture at the “National Conference on Innovative Minds Illuminating Future Frontiers: a tribute to the 2024 Nobel prize in Chemistry”, Madras Christian College, Chennai.
08/12/2024
  • Our paper "DeepPPAPredMut: deep ensemble method for predicting the binding affinity change in protein-protein complexes upon mutation."(R. Nikam, S. Jemimah and M. Michael Gromiha) has been covered as a Press release in more than 20 leading Newspapers.
05/12/2024
  • Prof. Michael Gromiha delivered an invited guest lecture at the Physics Association Meeting, Christian College, Marthandam.
05/12/2024
  • Published an article “Combinatorial Effects of 5-fluorouracil and Menadione on Wnt/β-catenin Pathway in Human Colorectal Cancer Cells”, V.P. Warrier, S. Venkatachalam, R. Sakthivel, M. Michael Gromiha , D. Karunagaran in Applied Biochemistry and Biotechnology.
29/11/2024
  • Prof. Michael Gromiha delivered a Keynote lecture at the "8th International Conference on Computational Biology and Bioinformatics", Kyoto, Japan.
20/11/2024
  • Published a book "Protein mutations: consequences on structure, functions and diseases". Edited by M. Michael Gromiha, World Scientific, Singapore
12/11/2024
  • Prof. Michael Gromiha delivered an invited talk at Chuo University, Tokyo.
11/11/2024
  • We congratulate Dr. Harini for successfully defending her thesis on "Computational resources for understanding and predicting the binding affinities of protein-nucleic acid complexes and their mutants".
05/11/2024
  • Prof. Michael Gromiha delivered an invited talk at KL University, Vijayawada.
01/11/2024
  • Published an article “Tracing ALS Degeneration: Insights from Spinal Cord and Cortex Transcriptomes”, N. P. Sneha, S.A.P. Dharshini, Y.-h. Taguchi and M. Michael Gromiha* in Genes.
24/10/2024
  • Ramakrishna Reddy presented a poster on "Predicting the stability of membrane proteins using sequence and structural features" at the Asia & Pacific Bioinformatics Joint Conference (APBJC) 2024 held in Japan.
24/10/2024
  • Fathima Ridha gave an oral talk on "Computational insights into binding affinity of membrane protein-protein complexes and mutational effects" at the Asia & Pacific Bioinformatics Joint Conference (APBJC) 2024 held in Japan.
23/10/2024
  • Fathima Ridha presented a poster on "Novel computational method for predicting the mutational effects on the binding affinity of membrane protein protein complexes " at the Asia & Pacific Bioinformatics Joint Conference (APBJC) 2024 held in Japan.
18/10/2024
  • Prof. Michael Gromiha delivered an invited talk at the Central University of Tamilnadu.
15/10/2024
  • Published an article "DeepPPAPredMut: deep ensemble method for predicting the binding affinity change in protein-protein complexes upon mutation", R. Nikam, S. Jemimah and M. Michael Gromiha* in Bioinformatics.
09/10/2024
  • Prof. Michael Gromiha delivered an invited talk at the "GNR Conference on Structural Biology and Drug Discovery", SRM institute of Science and Technology, Chennai, Oct 2024.
01/10/2024
  • We welcome Ms. Vaishnavi as a Project Associate
19/09/2024
  • Prof. Michael Gromiha delivered an invited talk at the National University of Singapore
16/09/2024
  • We congratulate Fathima Ridha for receiving the travel fellowship from SERB to present at "1st Asia & Pacific Bioinformatics Joint Conference (APBJC 2024)", Japan.
10/09/2024
  • Prof. Michael Gromiha delivered an invited talk at PSGR krishnammal College for Women, Coimbatore.
08/09/2024
  • Conducted NPTEL workshop on WEKA: Exploring machine learning for healthcare - batch 2.
06/09/2024
  • We welcome Ms. J. Afra to Protein Bioinformatics Lab as a Ph.D scholar.
05/09/2024
  • Published a review "Structural and functional studies on HIV protease: mechanism of action, subtypes, inhibitors and drug resistance", S. Venkatachalam, S.R. Krishnan, Y. Sayed and M. Michael Gromiha in Methods in Molecular Biology
01/09/2024
  • Prof. M. Michael Gromiha has been appointed as an Associate Editor of the journal, Bioinformatics and Biology Insights.
29/08/2024
  • Prof. M. Michael Gromiha delivered an invited talk at the "Faculty Development Program", at Vellore Institute of Technology, Vellore.
28/08/2024
  • Divya Sharma presented a poster on "Computational investigation of binding affinity of SARS-CoV-2 spike protein-neutralizing antibody complexes and their mutants" at 18th International Symposium of the Protein Society of Thailand (PST 2024) held at Bangkok, Thailand.
14/08/2024
  • Prof. M. Michael Gromiha delivered an invited lecture at the University of Wiwatersrand, Johannesburg, South Africa.
14/08/2024
  • Prof. Shoba Ranganathan from Macquarie University visited our lab on 14th August and interacted with students.
09/08/2024
05/08/2024
  • Dr. Kulandaisamy from Harvard Medical School, USA (Protein Bioinformatics Lab alumni) visited our lab on 5th August and interacted with students.
01/08/2024
  • Published a review “The Role of HSP90 and TRAP1 Targets on Treatment in Hepatocellular Carcinoma”, P.K. Praveen Kumar, H. Sundar, K. Balakrishnan, S. Subramaniam, R. Hemalath, M. Kevin and M. Michael Gromiha in Molecular Biotechnology.
27/07/2024
  • Prof. M. Michael Gromiha has been appointed as an Editorial Board Member of the journal, Methods (Elsevier).
11/07/2024
  • Published an article "rAbDesFlow: A novel workflow for computational recombinant antibody design for healthcare engineering.", S.R. Krishnan, D. Sharma, Y. Nazeer, M.V. Bose, T. Rajkumar, G. Jayaraman, N. Madaboosi and M. Michael Gromiha in Antibody Therapeutics.
11/07/2024
  • We congratulate Dr. Nela Pragathi Sneha for successfully defending her thesis on "Exploring neuron degeneration through transcriptome studies on Huntington’s disease and Amyotrophic lateral sclerosis".
07/06/2024
  • Published an article "CarbDistMut: Database on neutral and disease-causing mutations in human carbohydrate-binding proteins", N.R. Siva Shanmugam, A. kulandaisamy, K. Veluraja and M. Michael Gromiha in Glycobiology.
29/05/2024
  • Dr. Akila from Stanford University (Protein Bioinformatics Lab alumni) visited our lab on 29th May and delivered a talk.
15/05/2024
  • Prof. M. Michael Gromiha has been recognized as an inaugural ScholarGPS Highly Ranked Scholar (topmost 0.01% in Bioinformatics).
09/05/2024
  • Published an article "PRA-Pred: Structure-based prediction of protein-RNA binding affinity", K. Harini, M. Sekijima and M. Michael Gromiha In ternational Journal of Biological Macromolecules.
24/04/2024
  • Our paper "Elucidating important structural features for the binding affinity of spike - SARS-CoV-2 neutralizing antibody complexes" has been recognized as a top cited paper in PROTEINS: STRUCTURE, FUNCTION, AND BIOINFORMATICS.
19/04/2024
  • Published an article "Sialic acid analogue as inhibitor for human coronavirus OC43-A study by molecular dynamics simulations.", J. J. Blessy, N.R. Siva Shanmugam, K. Veluraja and M. Michael Gromiha in Journal of Carbohydrate Chemistry.
07/04/2024
  • Conducted NPTEL workshop on WEKA: Exploring machine learning for healthcare.
23/03/2024
  • Prof. M. Michael Gromiha delivered an invited talk at the workshop on "Establishing and Sustaining Cloud Infrastructure for Informatics-based Healthcare”, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), India.
22/03/2024
  • Prof. M. Michael Gromiha delivered an invited talk at Vellore Institute of Technology, Vellore, India.
20/03/2024
  • We congratulate Pragathi Sneha for receiving the Women Leading IITM 2024 award.
15/03/2024
  • Published an article "Mechanism of drug resistance in HIV-1 protease subtype C in the presence of Atazanavir", S.V. Sankaran, S.R. Krishnan, Y. Sayed and M. Michael Gromiha in Current Research in Structural Biology.
10/03/2024
  • Prof. M. Michael Gromiha delivered an invited talk at KL University, Vijayawada, India.
08/03/2024
  • Published an article "MPA-Pred: A machine learning approach for predicting the binding affinity of membrane protein-protein complexes", Fathima Ridha and M. Michael Gromiha in Proteins.
07/03/2024
  • Published a review “Importance of inter-residue contacts for understanding protein folding and unfolding rates, remote homology and drug design”, Harihar, K.M. Saravanan, M. Michael Gromiha and S. Selvaraj ​ in Molecular Biotechnology.
28/02/2024
  • Prof. M. Michael Gromiha delivered an invited talk at Chuo University, Tokyo, Japan.
22/02/2024
  • Published an Editorial “From Code to Cure: The Impact of Artificial Intelligence in Biomedical Applications”, M. Michael Gromiha*, P. Preethi and Medha Pandey ​ in BioMedInformatics.
12/02/2024
  • Published an article “ Predicting the immune escape of SARS-CoV-2 neutralizing antibodies upon mutation”, D. Sharma, P. Rawat, V. Greiff, V. Janakiraman and M. Michael Gromiha*​ in BBA: Molecular Basis of Diseaes.
07/02/2024
  • We congratulate Dr. Rahul Nikam for successfully defending his thesis on "Predicting the binding affinity of protein-protein complexes and their mutants using deep learning​​​"​​.
01/02/2024
  • Prof. M. Michael Gromiha delivered an invited talk at the “International Conference on Integrating Recent Innovations in Science and Technology: Shaping the Future”, Dhanalakshmi Srinivasan Engineering College, Perambalur.
26/01/2024
  • We are conducting PBI Lab symposium on "Bio-molecular interactions: Applications to diseases" on 26th & 31st Jan 2024.​​ We thank Prof. Velmurugan for joining us as chief guest.
15/01/2024
  • ​Prof. M. Michael Gromiha delivered an invited talk at Bioinformatics Institute, A*Star,​ Singapore.​​
01/01/2024
  • ​Published an article “Reliable method for predicting the binding affinity of RNA-small molecule interactions using machine learning”, S.R. Krishnan, A. Roy and M. Michael Gromiha*​ in Briefings in Bioinformatics.​​

26/12/2023
  • Published a letter to the Editor "Comment on “Thermodynamic database supports deciphering protein–nucleic acid interactions”, M. Michael Gromiha* and K. Harini in Trends in Biotechnology.
20/12/2023
  • Prof. M. Michael Gromiha delivered an invited talk at the Faculty Development Program on "Computer aided drug design and systems biology”, Holy Cross College, Trichy.
14/12/2023
  • Published an article "MutBLESS: A tool to identify disease-prone sites in cancer using deep learning.", M. Pandey and M. Michael Gromiha* in Biochimica et Biophysica Acta: Molecular Basis of Diseases.
14/12/2023
  • We congratulate Fathima for receiving the Good Oral Presentation Award at TAC-MI International Forum 2023, Tokyo Institute of Technology, Japan for her work on "Understanding the binding affinity of membrane protein-protein complexes: A computational approach".
13/12/2023
  • Prof. M. Michael Gromiha delivered a Keynote lecture at the TAC-MI International Forum 2023, Tokyo Institute of Technology, Japan.
11/11/2023
  • We congratulate Divya Sharma for receiving the travel fellowship from SERB for presenting the poster at GIW ISCB Asia 2023 conference held at Singapore from 18–21 November 2023.
30/11/2023
  • We congratulate Harini for receiving the Best Oral Presentation Award (First Prize) at the Indian Conference on Bioinformatics 2023 (InBix 2023), held at VIT Vellore.
26/11/2023
  • Fathima Ridha gave an oral talk on "Exploring the binding affinity and mutational implications in membrane protein-protein complexes: A computational approach" in the ISCB 2nd Asian Student Council Symposium (ASCS 2023).
25/11/2023
  • Harini K presented an oral talk on "Computational resources for understanding and predicting the binding affinity of protein-nucleic acid complexes" at the Indian Conference on Bioinformatics 2023 (InBix 2023), held at VIT Vellore.
24/11/2023
  • Divya Sharma presented a poster on "Computational approaches for understanding the binding affinity of SARS-CoV-2 spike protein-neutralizing antibody complexes and their mutants" at the GIW-ISCB Asia 2023 held at Novena, Singapore.
23/11/2023
  • Published an article "Deep learning-based method for predicting and classifying the binding affinity of protein-protein complexes.", R. Nikam, K. Yugandhar and M. Michael Gromiha* in Biochimica et Biophysica Acta: Proteins and Proteomics.
22/11/2023
  • Nela Pragathi Sneha presented a poster on "Understanding Huntington's disease transcriptome landscape using multi-omics approach" at the 22nd International Conference on Bioinformatics (InCoB 2023), Brisbane, Australia.
21/11/2023
  • We congratulate Dr. Medha Pandey for joining as a Post Doctoral Fellow at Harvard Medical School, Boston, USA.
20/11/2023
  • We congratulate Pragathi Sneha for receiving the InCoB Travel Award.
13/11/2023
  • Prof. M. Michael Gromiha delivered a series of invited guest lectures at IISER Thiruvananthapuram.
08/11/2023
  • We congratulate Medha Pandey for receiving the Institute Research Award.
01/11/2023
  • Published an article "Investigating neuron degeneration in Huntington’s disease using RNA-seq based transcriptome study", N.P. Sneha et al., in Genes.
13/10/2023
  • We congratulate Dr. Medha Pandey for successfully defending her thesis on "Analysis and development of machine learning models for driver mutations and disease-prone sites in cancer genomes".
10/10/2023
  • Prof. M. Michael Gromiha delivered an invited lecture at the International Conference cum Workshop on Artificial Intelligence Solutions for Pharmaceutical Research and Knowledge, NIPER, Punjab.
08/10/2023
  • Published an article "TMH Stab-pred: Predicting the stability of α-helical membrane proteins using sequence and structural features.", in Methods.
06/10/2023
  • Prof. Chandra Verma from Bioinformatics Institute, A*STAR, Singapore, visited our lab.
27/09/2023
  • Published a review "Bioinformatics approaches for understanding the binding affinity of protein-nucleic acid complexes" in Methods in Molecular Biology.
21/09/2023
  • We welcome Ms. Preethi P. to the Protein Bioinformatics Lab as a Ph.D. scholar.
10/09/2023
  • Conducted NPTEL workshop on Applications of Machine Learning Techniques in Biology using Weka.
07/09/2023
  • Published an article "TMKit: a Python interface for computational analysis of transmembrane proteins." in Briefings in Bioinformatics.
03/09/2023
  • Prof. M. Michael Gromiha delivered an invited lecture on the 2nd Anniversary of Prof. N. Srinivasan at IISc Bangalore.
18/08/2023
  • Registrations open for NPTEL workshop "Applications of Machine Learning Techniques in Biology using Weka".
09/08/2023
  • Published an Editorial "Protein recognition and associated diseases" in Frontiers in Bioinformatics.
31/07/2023
  • Multiple oral and poster presentations by lab members at ISMB/ECCB 2023 held at Lyon, France.
06/07/2023
  • Published a review "Computational approaches for identifying disease-causing mutations in proteins" in Advances in Protein Chemistry and Structural Biology.
01/07/2023
  • Prof. M. Michael Gromiha has been elected as a Fellow of the Chennai Academy of Sciences.
15/06/2023
  • Published an article "R-SIM: A database of binding affinities for RNA-small molecule interactions" in Journal of Molecular Biology.
01/01/2023
  • Published an article "MPAD: A database for binding affinity of membrane protein-protein complexes and their mutants." in Journal of Molecular Biology.

21/12/2022
  • Prof. M. Michael Gromiha delivered a Keynote lecture at the TAC-MI International Forum 2022, Tokyo Institute of Technology, Japan.
16/12/2022
  • Published an article "Identification of potential driver mutations in glioblastoma using machine learning", M. Pandey, P. Anoosha, D. Yesudhas and M. Michael Gromiha* in Briefings in Bioinformatics.
13/12/2022
  • Prof. Satoshi Murakami from Tokyo Institute of Technology, Japan visited our lab on 13th Dec 2022.
13/12/2022
  • We congratulate Divya Sharma for receiving the Social Impact Award at Tokyo Tech Academy for Convergence of Materials and Informatics (TAC-MI).
01/12/2022
  • Prof. M. Michael Gromiha delivered an invited talk at the 2nd International Conference on "Recent Trends in Structural Bioinformatics and Computer Aided Drug Design" at Alagappa University, Karaikudi.
25/11/2022
  • We welcome Mr. Suraj and Mr. Amit as PhD students.
24/11/2022
  • Published an article "Ab-CoV: a curated database for binding affinity and neutralization profiles of coronavirus related antibodies", P. Rawat et al., in Bioinformatics.
14/11/2022
  • Prof. M. Michael Gromiha delivered a Plenary lecture at the National Conference on “Technology & Innovation in Healthcare (NCTIH22)", Vinayaka Missions Kirupananda Variyar Medical College and Hospital, Salem.
10/11/2022
  • Published an article "Novel BH4-BCL-2 domain antagonists induce BCL-2 mediated apoptosis in triple negative breast cancer", V. Kanakaveti et al., in Cancers.
31/10/2022
  • Prof. M. Michael Gromiha delivered a Valedictory address at the National Conference on “Role of Artificial Intelligence in Molecular Medicine” at Alpha Arts and Science College, Chennai.
26/10/2022
  • Published a review "Computational approaches for investigating disease-causing mutations in membrane proteins: database development, analysis and prediction" in Current Topics in Medicinal Chemistry.
17/10/2022
  • Prof. M. Michael Gromiha has been elected as a Fellow of Indian National Science Academy (INSA).
08/10/2022
  • Prof. M. Michael Gromiha delivered a Plenary lecture at the International Symposium on "Recent Trends in Macromolecular Structure and Function, Marine Biotechnology and Bioinformatics", AMET University, Chennai.
06/10/2022
  • Published an article "Understanding the mutational frequency in SARS-CoV-2 proteome using structural features" in Computers in Biology and Medicine.
01/10/2022
  • Prof. M. Michael Gromiha delivered an Invited lecture at the National University of Singapore.
19/09/2022
  • We welcome Mr. Sankaran as a Project Associate.
03/09/2022
  • Conducted NPTEL workshop on Applications of Machine Learning Techniques in Biology using Weka.
22/08/2022
  • Published an article "Ad interim recommendations for diagnosing SARS-CoV-2 infection by the IFCC SARS-CoV-2 Variants Working Group" in Clinical Chemistry and Laboratory Medicine.
01/08/2022
  • Registrations closed for NPTEL workshop on Applications of Machine Learning Techniques in Biology using Weka.
16/07/2022
  • Prof. M. Michael Gromiha delivered an Invited talk at the Teachers’ Training Workshop jointly organized by IISER Thiruvananthapuram and the Department of Collegiate Education, Government of Kerala.
01/07/2022
  • Published an article "PCA-MutPred: Prediction of binding free energy change upon missense mutation in protein-carbohydrate complexes" in Journal of Molecular Biology.
22/06/2022
  • Prof. M. Michael Gromiha delivered an Invited lecture at Purdue University, USA.
15/06/2022
  • We congratulate Dr. Prabakaran for joining as a Post Doctoral Fellow at Rutgers University, USA.
05/06/2022
  • Published an article "Tumor heterogeneity and molecular characteristics of glioblastoma revealed by single-cell RNA-seq data analysis" in Genes.
26/05/2022
  • Prof. M. Michael Gromiha delivered a series of lectures at the Faculty Development Program on “Basics of Bioinformatics” organized by Anna University, Trichy and NIT Warangal.
13/05/2022
  • Published an article "Evaluation of in silico tools for the prediction of protein and peptide aggregation on diverse datasets" in Briefings in Bioinformatics.
01/05/2022
  • We congratulate Siva Shanmugam for receiving the Institute Research Award.
25/04/2022
  • We congratulate Dr. Akila for joining as a Post Doctoral Fellow at Stanford University, USA.
23/04/2022
  • Prof. M. Michael Gromiha delivered an Invited talk at the National Conference on "Recent Advances in Life Sciences towards Health Care" at JSS Academy of Higher Education and Research, Ooty.
22/04/2022
  • Prof. Chandra Verma from Bioinformatics Institute, A*STAR, Singapore, visited our lab.
20/04/2022
  • We congratulate Dr. R. Prabakaran for successfully defending his thesis on "Sequence and structural studies of aggregation prone regions in proteins".
11/04/2022
  • Published an article "Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein" in Journal of Biomolecular Structure and Dynamics.
24/03/2022
  • Prof. M. Michael Gromiha received the ASC-Masila Vijaya Award for Excellence in Scientific Research and Publications from The Academy of Sciences, Chennai.
09/03/2022
  • Prof. M. Michael Gromiha delivered an Inaugural address at the Workshop on "Next Generation Sequencing Technologies" at Vels University, Chennai.
07/03/2022
  • We welcome Dr. Sudha Govindarajan as a DBT-RA Fellow.
02/03/2022
  • Published a Letter to the Editor "Srinivasan (1962–2021) in Bioinformatics and beyond" in Bioinformatics.
28/02/2022
  • Prof. M. Michael Gromiha delivered an Invited talk at the National Conference on "Prevalent and Prospective Paradigms in Machine Learning for Applications in Biology" at Nirmala College for Women, Coimbatore.
21/02/2022
  • Published an article "Elucidating important structural features for the binding affinity of spike–SARS-CoV-2 neutralizing antibody complexes" in PROTEINS: Structure, Function and Bioinformatics.
10/02/2022
  • Published an article "Illustrative tutorials for ProThermDB: Thermodynamic database for proteins and mutants" in Current Protocols.
26/01/2022
  • Published an article "A novel hybrid SEIQR model incorporating the effect of quarantine and lockdown regulations for COVID-19" in Scientific Reports.
24/01/2022
  • Prof. M. Michael Gromiha delivered a Keynote lecture at the International Forum for Tokyo Tech Academy for Convergence of Materials and Informatics (TAC-MI) at Tokyo Institute of Technology, Japan.
18/01/2022
  • We welcome Dr. Praveen Kumar as a SERB-TARE Fellow.

01/01/2021
  • Published an article "ProNAB: Database for binding affinities of protein-nucleic acid complexes and their mutants.", K. Harini, A. Srivastava, A. Kulandaisamy and M. Michael Gromiha in Nucleic Acids Research.
10/12/2021
  • Published an article "Effect of Charged Mutation on Aggregation of a Pentapeptide: Insights from Molecular Dynamics Simulations.", R. Prabakaran et al., in PROTEINS: Structure, Function and Bioinformatics.
30/11/2021
  • Prof. M. Michael Gromiha delivered a series of lectures at the Faculty Development Program on “Advanced Bioinformatics” organized by Anna University, Trichy and NIT, Warangal.
24/11/2021
  • Prof. M. Michael Gromiha delivered an Invited talk at the AICTE Training and Learning on "Computer Genomics Tools for Next Generation Sequencing and Biomedical Data Analysis" at Bharathiar University, Coimbatore.
17/11/2021
  • Published an article "PPAR-responsive elements (PPREs) enriched with Alu repeats revealed a descriptive contribution to PPARγ-DNMT1 interactions in the genome" in Cancers.
03/11/2021
  • Published an article "Exploring the sequence features determining amyloidosis in human antibody light chains" in Scientific Reports.
30/10/2021
  • Prof. M. Michael Gromiha is listed as one of the topmost 0.5% of researchers in Bioinformatics, Biophysics and overall rank based on standardized citation metrics.
29/10/2021
  • Our article “AbsoluRATE: An in-silico method to predict the aggregation kinetics of native proteins” published in BBA – Proteins and Proteomics has been featured in the BBA Collection “Artificial Intelligence for Biochemistry and Molecular Biology: AI is Learning to Help”.
27/10/2021
  • We congratulate Ramakrishna Reddy for receiving the Prime Minister's Research Fellowship.
25/10/2021
  • We congratulate Dr. Puneet Rawat for joining as a Post Doctoral Fellow at the University of Oslo, Norway.
23/10/2021
  • We congratulate Divya Sharma and Fathima Ridha for receiving the Prime Minister's Research Fellowship.
19/10/2021
  • Prof. M. Michael Gromiha delivered an Invited talk at the Health Informatics Summit at IIIT Delhi.
18/10/2021
  • We congratulate Dr. Vishnupriya Kanakaveti for joining as a Post Doctoral Fellow at Stanford University, USA.
11/10/2021
  • We welcome Ramakrishna Reddy to the Protein Bioinformatics Lab as a Ph.D. scholar.
03/10/2021
  • We congratulate Harini for receiving the Overseas Visiting Doctoral Fellowship (OVDF) at Purdue University from the Science and Engineering Research Board.
27/09/2021
  • Published an article "Investigations on the binding specificity of β-galactoside analogues with human galectin-1 using molecular dynamics simulations" in Journal of Biomolecular Structure and Dynamics.
20/09/2021
  • Prof. M. Michael Gromiha has been appointed as an Associate Editor in Bioinformatics Advances.
10/09/2021
  • Published an article "AbsoluRATE: An in-silico method to predict the aggregation kinetics of native proteins" in BBA – Proteins and Proteomics.
28/08/2021
  • Published an article "Tackling COVID-19 using disordered-to-order transition of residues in the spike protein upon ACE2 binding" in PROTEINS: Structure, Function and Bioinformatics.
23/08/2021
  • Prof. M. Michael Gromiha has been appointed as an Associate Editor in Frontiers in Bioinformatics.
12/08/2021
  • Prof. M. Michael Gromiha delivered a series of lectures on “Basics and Applications of Bioinformatics” at IIT Dhanbad.
07/08/2021
  • We welcome Ms. Sowmya R. K. on joining the lab as an external Ph.D. scholar.
01/08/2021
  • Published an article "Exploring antibody repurposing for COVID-19: Beyond presumed roles of therapeutic antibodies" in Scientific Reports.
28/07/2021
  • We congratulate Dr. Ambuj Srivastava for joining as a Post Doctoral Fellow at the University of California San Diego, USA.
16/07/2021
  • We congratulate Dr. A. Kulandaisamy for receiving the Best Thesis Award.
01/07/2021
  • Published an article "Understanding disorder-to-order transitions in protein–RNA complexes using molecular dynamics simulations" in Journal of Biomolecular Structure and Dynamics.
22/06/2021
  • Prof. M. Michael Gromiha delivered a series of lectures at the Faculty Development Program on “Basics of Bioinformatics” organized by Anna University, Trichy and NIT, Warangal.
16/06/2021
  • We congratulate Dr. Vishnupriya Kanakaveti for successfully defending her thesis.
11/06/2021
  • We congratulate Dr. A. Kulandaisamy for receiving the Institute Research Award.
01/06/2021
  • Published a review "Protein Aggregation: In silico Algorithms and Applications" in Biophysical Reviews.
24/05/2021
  • We congratulate Dr. A. Kulandaisamy for joining as a Post Doctoral Fellow at Harvard Medical School, Boston, USA.
13/05/2021
  • Prof. M. Michael Gromiha delivered a Plenary lecture at the Workshop on “Advances in Bioinformatics” at NIT Warangal.
08/05/2021
  • Published an article "Deciphering the role of residues involved in disorder-to-order transition regions in archaeal tRNA methyltransferase 5" in Genes.
03/05/2021
  • We congratulate Dr. Ambuj Srivastava for successfully defending his thesis.
11/04/2021
  • Published an article "Exploring common therapeutic targets for neurodegenerative disorders using transcriptome study" in Frontiers in Genetics.
24/03/2021
  • Published an article "COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics" in Infection.
12/03/2021
  • Published an article "Predicting potential residues associated with lung cancer using deep neural networks" in Mutation Research.
08/03/2021
  • We congratulate Dr. Akila for successfully defending her thesis.
01/03/2021
  • We congratulate Dr. Kulandaisamy for successfully defending his thesis.
26/02/2021
  • Published an article "Mutations in transmembrane proteins: diseases, evolutionary insights and prediction" in Briefings in Bioinformatics.
19/02/2021
  • Prof. M. Michael Gromiha delivered an Invited talk at Bharathiar University, Coimbatore.
18/02/2021
  • Prof. M. Michael Gromiha delivered an Invited talk at the 9th Tokyo Tech International Symposium on “Life Science and Technology” at Tokyo Institute of Technology, Japan.
06/02/2021
  • Published an article "Why are ACE2 binding coronavirus strains SARS-CoV/SARS-CoV-2 wild and NL63 mild?" in PROTEINS: Structure, Function and Bioinformatics.
15/01/2021
  • Published an article "Identification of Transcription Factors, Biological Pathways, and Diseases as Mediated by N6-methyladenosine using Tensor Decomposition-Based Unsupervised Feature Extraction" in Applied Sciences.

01/01/2020
  • Published an article "ANuPP: A versatile tool to predict aggregation nucleating regions in peptides and proteins", R. Prabakaran, P. Rawat, S. Kumar and M. Michael Gromiha* in Journal of Molecular Biology.
28/12/2020
  • We congratulate Dr. Puneet Rawat for successfully defending his thesis on "Computational approaches for understanding the aggregation kinetics of proteins and mutants".
25/12/2020
  • Published an article "Prediction of protein-carbohydrate complex binding affinity using structural features", N.R.S. Shanmugam, J. Blessy, K. Veluraja and M. Michael Gromiha* in Briefings in Bioinformatics.
18/12/2020
  • Prof. M. Michael Gromiha delivered an invited talk at the faculty development program on "Current Trends in Life Sciences" at Vellore Institute of Technology.
09/12/2020
  • Published an article "ProThermDB: Thermodynamic database for proteins and mutants revisited after 15 years", R. Nikam, A. Kulandaisamy, K. Harini, D. Sharma and M. Michael Gromiha* in Nucleic Acids Research.
17/11/2020
  • Published an article "Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19", D. Barh et al., M. Michael Gromiha and P. Ghosh in Computers in Biology and Medicine.
09/11/2020
  • We welcome Fathima as a Ph.D scholar.
04/11/2020
  • Prof. M. Michael Gromiha is ranked as the best scientist (No. 1) in Bioinformatics from India based on citations and publications (Stanford University survey).
20/10/2020
  • Published an article "MPTherm-pred: Analysis and prediction of thermal stability changes upon mutations in transmembrane proteins", A. Kulandaisamy et al. and M. Michael Gromiha in Journal of Molecular Biology.
08/10/2020
  • Published an article "Predicting the effect of variants associated with Alzheimer’s disease using machine learning", U. Rangaswamy et al. and M. Michael Gromiha in Computers in Biology and Medicine.
27/09/2020
  • Published a review "Therapeutic targets and computational approaches on drug development for COVID-19", A. Shanmugam et al. and M. Michael Gromiha* in Current Topics in Medicinal Chemistry.
10/09/2020
  • We congratulate Uday for getting PhD admission at SISSA, Italy.
20/08/2020
  • Published an article "New insights into the stereospecific reduction by an (S)-specific carbonyl reductase from Candida parapsilosis ATCC 7330", S. Sudhakara et al. and M. Michael Gromiha in Catalysis Science & Technology.
03/08/2020
  • We congratulate Dr. Sherlyn Jemimah for successfully defending her thesis on protein-protein complex binding free energy changes.
25/07/2020
  • Published an article "Insights into changes in binding affinity caused by disease mutations in protein-protein complexes", S. Jemimah and M. Michael Gromiha* in Computers in Biology and Medicine.
11/07/2020
  • We congratulate Sherlyn Jemimah for receiving the Institute Research Award 2019–2020.
24/06/2020
  • Prof. M. Michael Gromiha delivered an invited talk at the International Webinar Series on “Advances in Supramolecular and Biomolecular Research”, SSN College of Engineering, Chennai.
20/06/2020
  • Published an article "MPTherm: Database for Membrane Protein Thermodynamics for understanding folding and stability", A. Kulandaisamy et al. and M. Michael Gromiha in Briefings in Bioinformatics.
08/06/2020
  • Prof. M. Michael Gromiha delivered an inaugural address at the Virtual Workshop on "Protein Bioinformatics".
30/05/2020
  • We congratulate Sherlyn Jemimah for submitting her Ph.D thesis to IIT Madras.
23/05/2020
  • Published an article on drug repurposing against SARS-CoV-2 protease, N. Muralidharan et al. and M. Michael Gromiha in Journal of Biomolecular Structure and Dynamics.
01/05/2020
  • Published a book "Protein interactions: computational methods, analysis and applications", edited by M. Michael Gromiha, World Scientific, Singapore.
  • Published multiple book chapters covering protein–protein, protein–nucleic acid, protein–carbohydrate interactions and QSAR methods.
19/04/2020
  • Published an article "ProCaff: protein-carbohydrate complex binding affinity database", S. Shanmugam et al. and M. Michael Gromiha in Bioinformatics.
11/04/2020
  • Published an article "Neurodegenerative diseases – Is metabolic deficiency the root cause?", V.R. Muddapu et al. and M. Michael Gromiha in Frontiers in Neuroscience.
30/03/2020
  • Published an article on dengue fever inhibitors, A. Shanmugam et al. and M. Michael Gromiha in Current Topics in Medicinal Chemistry.
10/03/2020
  • We congratulate Nisha Muralidharan and Siva Shanmugam for Best Poster Awards at the 5th IITM–Tokyo Tech Joint Symposium.
08/03/2020
  • 5th IITM–Tokyo Tech Joint Symposium on Bioinformatics held at IIT Madras, Chennai.
21/02/2020
  • Published an article "CPAD 2.0: A repository of curated experimental data on aggregating proteins and peptides", P. Rawat et al. and M. Michael Gromiha in Amyloid.
11/02/2020
  • Published an article on AspRS–tRNA complexes, C. Ramakrishnan et al. and M. Michael Gromiha in Journal of Biomolecular Structure and Dynamics.
05/02/2020
  • We welcome Divya Sharma as an M.S scholar.
11/01/2020
  • We congratulate Dr. P. Anoosha for receiving the Pelotonia Post-Doctoral Fellowship.
10/01/2020
  • Published an article on RNA-seq variant detection, A.P. Dharshini et al. and M. Michael Gromiha in Genomics.

18/12/2019
  • Published a review "Computational approaches for identifying potential inhibitors on targeting protein interactions in drug discovery", V. Kanakaveti et al. and M. Michael Gromiha in Advances in Protein Chemistry and Structural Biology.
16/12/2019
  • Published an article "A prospective compound screening contest identified broader inhibitors for Sirtuin 1", S. Chiba et al. in Scientific Reports.
12/12/2019
  • We welcome Dr. Sujatha Roy as a SERB-TARE Fellow.
06/12/2019
  • We congratulate Dr. Dhanusha Yesudhas for receiving the Young Scientist Fellowship from the Indian Council of Medical Research.
28/11/2019
  • Published an article "Pred-MutHTP: Prediction of disease-causing and neutral mutations in human transmembrane proteins", A. Kulandaisamy et al. and M. Michael Gromiha in Human Mutation.
10/11/2019
  • Published an article "Investigating the energy crisis in Alzheimer disease using transcriptome study", S.A.P. Dharshini et al. and M. Michael Gromiha in Scientific Reports.
06/11/2019
  • Published an article "ProAffiMuSeq: Sequence-based method to predict the binding free energy change of protein-protein complexes upon mutation using functional classification", S. Jemimah et al. and M. Michael Gromiha in Bioinformatics.
21/10/2019
  • Prof. M. Michael Gromiha has been appointed as Section Editor (Protein Bioinformatics) in Current Protein and Peptide Science.
20/10/2019
  • Published an article "Mutational landscape of the BAP1 locus reveals an intrinsic control to regulate the miRNA network and the binding of protein complexes in uveal melanoma", A. Sharma et al. and M. Michael Gromiha in Cancers.
15/10/2019
  • Dr. P. Anoosha from Ohio State University (Alumni, Protein Bioinformatics Lab) visited our lab and delivered a talk.
04/10/2019
  • Published an article "AggreRATE-Pred: A mathematical model for the prediction of change in aggregation rate upon point mutation", P. Rawat et al. and M. Michael Gromiha in Bioinformatics.
13/09/2019
  • Prof. M. Michael Gromiha is listed among the top 0.5% of researchers in Bioinformatics and Biophysics based on standardized citation metrics published in PLoS Biology.
05/09/2019
  • We congratulate Kulandai Samy for receiving the Initiative for Biological Systems Engineering (IBSE) Travel Grant Award 2019.
02/08/2019
  • Prof. M. Michael Gromiha visited the National Institute of Immunology, New Delhi and delivered an invited talk on Protein Interactions.
27/07/2019
  • Prof. M. Michael Gromiha and Dr. Sakthivel visited St. Petersburg Polytechnic University, Russia and delivered invited talks on Protein Structure and Function.
22/07/2019
  • Ambuj Srivastava and Puneet Rawat presented their work at ISMB–ECCB 2019, Basel, Switzerland.
09/07/2019
  • Published an article "BorodaTM: prediction of disease-associated mutations in membrane proteins with known 3D structure", P. Popov et al. and M. Michael Gromiha in PLoS ONE.
28/06/2019
  • Members of the Protein Bioinformatics Lab visited SciLifeLab, Stockholm University, Sweden for a joint workshop during June 23–28, 2019.
16/05/2019
  • Published an article "Seq2Feature: a comprehensive web-based feature extraction tool", Rahul Nikam and M. Michael Gromiha in Bioinformatics.
  • Published an article "Amarogentin activates AMP-activated protein kinase (AMPK) to exert beneficial vasculo-metabolic effects", P. Uma Rani et al. and M. Michael Gromiha in BBA – General Subjects.
03/04/2019
  • Published an article "Forging new scaffolds from old: Combining scaffold hopping and hierarchical virtual screening for identifying novel Bcl-2 inhibitors", V. Kanakaveti et al. and M. Michael Gromiha in Current Topics in Medicinal Chemistry.
25/03/2019
  • Published an article "Drug repositioning for dengue hemorrhagic fever by integrating multiple omics analyses", T. Amemiya et al. and M. Michael Gromiha in Scientific Reports.
23/03/2019
  • We congratulate Ambuj Srivastava for securing a silver medal in Table Tennis during the PG League.
  • We congratulate Medha Pandey for securing gold and silver medals in Table Tennis competitions.
  • We congratulate Kulandaisamy for securing a silver medal in Hockey during the Men's Schroeter competition.
02/03/2019
  • Nisha Muralidharan received an award for expressing views on breaking stereotypes at the Taboo event, Chennai.
20/02/2019
  • Prof. M. Michael Gromiha delivered an invited talk at the International Conference on Chemical and Structural Biology, PRIST University, Chennai.
18/02/2019
  • Prof. Chandra Verma from Bioinformatics Institute, A*STAR, Singapore visited our lab.
17/02/2019
  • Prof. Yasien Sayed from the University of the Witwatersrand, Johannesburg visited our lab.
01/02/2019
  • Published an article "Statistical analysis of disease-causing and neutral mutations in human membrane proteins", A. Kulandaisamy et al. and M. Michael Gromiha in PROTEINS.
  • We welcome Nisha Muralidharan as a Junior Research Fellow.
28/01/2019
  • Published an article on influenza A virus H5N1–sialic acid complexes, R.A. Jeyaram et al. and M. Michael Gromiha in Journal of Biomolecular Structure and Dynamics.
23/01/2019
  • Dr. Narayanan and Dr. Sudha from Stockholm University visited our lab.
22/01/2019
  • Prof. M. Michael Gromiha delivered an invited talk at Presidency College, Chennai.
08/01/2019
  • Prof. Ashok Venkitaramanan from the University of Cambridge visited our lab.
07/01/2019
  • Published an article "HuVarBase: A human variant database with comprehensive information at gene and protein levels", K. Ganesan et al. and M. Michael Gromiha in PLoS ONE.

27/12/2018
  • Professor David Baker, Director of the Institute for Protein Design, University of Washington visited our lab on 27th Dec 2018.
26/12/2018
  • Dr. Yugandhar Kumar from Cornell University (Alumni from Protein Bioinformatics Lab) delivered a talk on 26th Dec 2018.
12/12/2018
  • Professor Michael Gromiha delivered an invited talk at Tokyo Institute of Technology, Japan on 12th Dec 2018.
30/11/2018
  • Published an article "Structural insights into the aggregation mechanism of huntingtin exon 1 protein fragment with different polyQ-lengths." by S. Binny Priya and M. Michael Gromiha in Journal of Cellular Biochemistry.
25/11/2018
  • Published an article "Influence of amino acid mutations and small molecules for targeted inhibition of proteins involved in cancer." by V. Kanakaveti, P. Anoosha, R. Sakthivel, S.K. Rayala and M. Michael Gromiha in Current Topics in Medicinal Chemistry.
15/11/2018
  • Published an article "Protein structural bioinformatics: an overview" by M. Michael Gromiha, R. Nagarajan and S. Selvaraj in Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics.
30/10/2018
  • Professor M. Michael Gromiha received the Tamilnadu Scientist Award (TANSA Award) in Biological Sciences for the year 2017.
12/10/2018
  • Published an article "An in-silico method for identifying aggregation rate enhancer and mitigator mutations in proteins." by Puneet Rawat, Sandeep Kumar and M. Michael Gromiha in International Journal of Biological Macromolecules.
28/09/2018
  • We congratulate Kulandaisamy for receiving the best poster award at 17th International conference on Bioinformatics held at JNU, New Delhi during the period 26 - 28 September 2018.
21/09/2018
  • Professor Shoba Ranganathan visited our lab on 21st Sept 2018 and delivered an invited talk.
09/07/2018
  • Sherlyn Jemimah presented a poster titled "A Computational Study of the Additivity of Binding Free Energy in Protein-Protein Complexes Upon Double Mutation" at The Protein Society's 32nd Annual symposium held on 9 - 12 July 2018 in Boston, Massachusetts, USA.
26/06/2018
  • Dharshini, S. Akila Parvathy, presented a poster titled "Identifying suitable spliced mapper and genomic assembly for variant detection" at Galaxy Community Conference and Bioinformatics Open Source Conference 2018 (GCCBOSC2018) held at Portland, Oregon, United States from 25-30 June, 2018.
04/06/2018
  • Published an article "Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis" by S. Akila Parvathy Dharshini, Y-h. Taguchi and M. Michael Gromiha in Genomics.
16/05/2018
  • Published an article "Deciphering RNA-Recognition Patterns of Intrinsically Disordered Proteins" by Ambuj Srivastava, Shandar Ahmad, and M. Michael Gromiha in International Journal of Molecular Sciences.
  • Published an article "Identification and analysis of key residues in protein—RNA complexes" by A. Kulandaisamy, Ambuj Srivastava, Pradeep Kumar, Nagarajan Raju and Dr. M. Michael Gromiha in IEEE/ACM Transactions on Computational Biology and Bioinformatics.
10/05/2018
  • We congratulate Sherlyn Jemimah for Protein Science (sponsored by Wiley) Travel Award.
  • We welcome new members Dr. Dhanusha Yesudhas as a Research Associate and Priyadharshini Kannan as a Juniour Research Fellow.
02/04/2018
  • We welcome new member Dr. J. Jino Blessy as a Research Associate.
15/03/2018
  • We have released MutHTP, a database for Mutations in Human Transmembrane Proteins. It can be accessed here.
06/03/2018
  • Published an article "Identification and analysis of key residues involved in folding and binding of protein-carbohydrate complexes." by N.R. Siva Shanmugam, J. Fermin Angelo Selvin, K. Veluraja and M. Michael Gromiha in Protein & Peptide Letters.
01/02/2018
  • Published an article "MutHTP: Mutations in Human Transmembrane Proteins." by A. Kulandaisamy et al. in Bioinformatics.
26/01/2018
  • An article "Exploring additivity effects of double mutations on the binding affinity of protein-protein complexes" by Sherlyn Jemimah and M. Michael Gromiha has been accepted for publication in Proteins: Structure, Function, and Bioinformatics.
19/12/2017
  • Published an article "Dissecting and analyzing key residues in protein-DNA complexes" by A. Kulandaisamy et al. in Journal of Molecular Recognition.
  • Conducted 1st Indo-Sweden discussion meeting on "Protein Bioinformatics and Deep Learning" on December 10-11, 2017.
  • Conducted 4th IIT Madras-Tokyo Tech Joint Symposium on "Frontiers in Bioinformatics: Large scale data analysis, Resources and Drug Design" on November 10-11, 2017.
18/07/2017
  • Three "Research Associate" positions are available.
  • Two "Junior Research Fellow" positions are available.
17/07/2017
  • Organising 4th IITM - Tokyo Tech Joint Symposium on the topic "Frontiers in Bioinformatics: Large scale data analysis, Resources and Drug design" from 10th - 11th November 2017.
01/07/2017
  • Released new lab website.
16/06/2017
  • Dr. S. Selvaraj from Bharathidasan University visited our lab from 14 to 16 June, 2017.
07/06/2017
  • One "Research Associate" and two "Junior Research Fellow" positions are available.
05/06/2017
  • Received a research grant from CSIR, Government of India for the project "Predictive modeling of nucleic acid recognition dynamics and structured complex formation by disordered proteins" (2017–2019).
20/05/2017
  • Published an article "PROXiMATE: A database of mutant protein-protein complex thermodynamics and kinetics." in Bioinformatics.
  • Released PROXiMATE database for thermodynamic data of mutant protein heterodimer complexes.
20/03/2017
  • Published an article "Aggregation Propensity of Human Proteome: Insights from large-scale data analyses." in Proteins.
25/02/2017
  • Prof. Dr. Dimitrij Frishman visited our lab under Indo-Russia bilateral research project.
01/02/2017
  • Published a review article "Protein-protein interactions: scoring schemes and binding affinity." in Current Opinion in Structural Biology.
25/01/2017
  • Two project positions are available.
06/01/2017
  • Received DST grant under Indo-Sweden bilateral program for "Deep learning for life sciences" (2017–2019).
16/12/2016
  • Article on functional groups in predicting activity of Bcl-2 inhibitors accepted in Chem. Biol. Drug Des.
  • Published articles in Current Protein & Peptide Science and International Journal of Biological Macromolecules.
29/09/2016
  • Published an article on quercetin derivatives as dengue polymerase inhibitors in Journal of Biomolecular Structure and Dynamics.