MPA-MutPred: Membrane Protein complex Mutation Affinity Predictor

FREQUENTLY ASKED QUESTIONS

  1. What is MPA-MutPred?
    2. MPA-MutPred is a webserver to calculate the binding free energy change (ΔΔG in kcal/mol) upon mutation in membrane protein-protein dimer complexes. It uses different sequence- and structure-based features in a regression model to predict ΔΔG in kcal/mol. For more information about the features kindly refer to the publication.
  2. Why is my input not being accepted by the server?
    3. There are a number of reasons why our server may not accept a given input. Please ensure that:
    • All * fields are inputed
    • The mentioned PDB ID and chain identifiers are correct and available in the PDB database
    • The user uploaded PDB file match with pdb format
    • The mutations are in the specified format: wt-chain-position-mutation
  3. Why am I facing issues with the display of the website on my browser?
    4. The website may be best viewed using the latest version of a browser such as Google Chrome or Mozilla Firefox.