PRA-Pred Protein-RNA complex Binding Affinity Prediction

PRA-Pred

This server predicts protein-RNA binding affinity using structure-based features and classes based on RNA strand, structure and function of protein. We found that RNA base-step parameters, number of atomic contacts between the RNA and protein, interaction energies, contact potentials, and hydrogen bonds are important to understand the binding affinity. PRA-Pred shows a correlation of 0.85 and a mean absolute error(MAE) of 0.81 in Self-consistency, correlation of 0.77 and a MAE of 1.02 kcal/mol in jack-knife test.

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human SRSF2 RRM in complex with 5'-UGGAGU-3' (PDB:2LEC)

Crystal structure of O-Phosphoseryl-tRNA kinase complexed with anticodon-stem/loop truncated tRNA(Sec) (PDB:3AM1)

Crystal structure of Hfq-RNA Complex (PDB:1KQ2)

Crystal structure of STEM LOOP RNA-ADAR2 DSRBM2 complex (PDB:2L2K)

Crystal structure of FBF-2/gld-1 FBEb complex (PDB:3K62)

Crystal structure of E. coli glutaminyl-tRNA synthetase bound to native tRNA( (PDB:4JYZ)