Welcome to V_LAmY-Pred

The light chain (AL) amyloidosis is a disease caused by the aggregation of light chain of antibodies into amyloid fibrils. The amyloid deposits can affect wide range of organs and consequently present a wide range of symptoms. Aggregation of monoclonal antibodies is also a major hurdle in antibody therapeutics which has important applications in treatment of cancers, autoimmune diseases and other metabolic disorders. The higher sequence conservation and presence of APRs in both amyloid and non-amyloid antibodies make it harder for conventional aggregation-prone region prediction software to predict the actual amyloidogenicity of the antibody. A webserver entitled “V_LAmY-Pred” (Prediction of amyloidogenic immunoglobulin) has been developed for the classification of amyloid and non-amyloid antibodies. We have used ANARCI tool in the webserver to predict the FRs and CDRs in the variable light chain region using IMGT numbering. The webserver takes the variable region sequence of the light chain as an input and predicts the amyloidogenic/non-amyloidogenic nature of the sequence.

Read the Tutorial for more information in the left hand tab..