Glossary
Entry ID | Unique identifier for the entry. |
Gene Name | Name of the gene that code for the protein sequence |
UniProt | UniProtKB accession number of the protein sequence |
Mutation | Protein level mutation. Eg. TRP(W) -> ALA(A) |
PDB ID | Protein 3D-structure ID from Protein Data Bank |
Mutation type | Different types of mutations Eg. Insertion, Deletion, Missense and Nonsense |
Effect of mutation | A given mutation is disease-associated or neutral Disease: Mutation reported as disease-associated Neutral: Mutation that doesn't implicated in disease |
Experimental 3D structures | Whether experimental 3D structure is known or not |
Disease Name: | Name of the disease or the disease sample (in the case of cancer) in which muations have been found |
Disease class | 14 different classes based on Kegg Human disease |
Source | Name of the data source 1. Humsavar 2. SwissVar 3. ClinVar 4. COSMIC 5. 1000 Genomes |
Conservation Score | The residues are evolutionary important. Score varies between 0 (very less conserved) and 1 (more conserved) |
Results per page | Users can select number of result entries in per page. Maximum upto 200. |
Search by | Conditional operator to search the user queries |
Chromosome number and genome position | Mutation at genomic position on a chromosome |
Nucleotide mutation | Gene level mutation (Eg. TCC -> TGC) |
Origin | Origin of the mutation whether it is Germline, Somatic or unknown Germline: mutation occurs in a germ cell Somatic: mutation occurs in a somatic cell Unknown: origin unknown |
Interface residues | Whether the mutation site is located in the interface of protein-carbohydrate complexes or not |
Predicted ΔΔG residues | Predicted ΔΔG (kcal/mol) values using our earlier prediction method based on protein-carbohydrate classifications (PCA-MutPred). |
Neighbouring residues | The neighboring residues of the mutation site on both N and C terminals using window length 7 |
PDB residues mapped | Mutation is mapped with 3D structure numbering for each PDB ID and chain (if available) |
Uniprot Isoforms | UniprotKB accession number of the isoform in the case where the mutation matches to the isoform sequence |
Glycosciences.de | Information about the carbohydrate structures (i) pdb2linucs (Carbohydrate information in LINUCS-Code) (ii) pdb-care (PDB CArbohydrate REsidue check) (iii) CARP (CArbohydrate Ramachandran Plot) |
Glygen | Computational and Informatics Resources for Glycoscience |
GlyTouCan | Unique accession numbers to glycan from GlyTouCan repository |