CarbDisMut

Statistics of the dataset

Summary of the database

Effect of mutation	Insertion	Deletion	Missense	Nonsense
Disease	22193	43158	1016508	88471
Neutral	71	378	38080	107

Number of entries	1208966
Total number of unique carbohydrate binding proteins	7187
Total number of distinct disease mutations	1170330
Total number of distinct proteins in disease mutations	7156
Number of disease mutations in the interface	105489
Total number of distinct neutral mutations	38636
Total number of distinct proteins in neutral mutations	5248
Number of neutral mutations in the interface	4288

The below histogram shows the distribution of ΔΔG values for disease-causing and neutral mutations.

Frequency matrix of neutral mutations (%)

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	0	0	0.39	0.21	0	0.72	0	0	0.01	0.01	0	0	0.52	0	0.01	0.9	3.46	2.96	0	0
C	0	0	0	0	0.11	0.09	0	0	0	0	0	0	0	0	0.24	0.23	0	0	0.06	0.28
D	0.2	0	0	0.99	0	0.71	0.44	0	0	0	0	1.68	0	0	0	0.01	0	0.31	0	0.33
E	0.35	0	1.07	0	0	0.65	0	0	2.12	0.01	0	0	0	0.7	0	0.01	0.01	0.23	0	0
F	0	0.1	0	0	0	0	0	0.11	0	0.73	0	0	0	0	0	0.3	0	0.15	0	0.14
G	0.59	0.18	0.83	0.6	0	0	0	0	0	0	0	0	0	0	1.68	1.76	0	0.61	0.09	0
H	0	0	0.1	0	0	0	0	0	0	0.14	0	0.16	0.17	0.47	0.88	0	0	0	0	0.65
I	0	0	0	0	0.23	0	0	0	0.04	0.33	0.58	0.15	0	0	0.02	0.12	1.24	2.44	0	0
K	0	0	0	0.82	0	0	0	0.06	0	0	0.1	0.57	0	0.32	1.24	0	0.24	0	0	0
L	0.01	0.01	0	0.01	1.19	0	0.08	0.35	0	0	0.31	0	0.81	0.13	0.34	0.28	0	1.16	0.06	0.01
M	0	0	0	0	0	0	0	0.67	0.11	0.39	0	0	0	0	0.06	0	0.75	1.19	0	0
N	0	0	0.57	0.01	0	0	0.25	0.17	0.59	0	0	0	0	0	0	2.1	0.24	0	0	0.12
P	0.79	0	0	0	0	0	0.29	0	0	2.85	0	0	0	0.24	0.72	1.96	0.59	0	0	0
Q	0	0	0	0.5	0	0	0.84	0	0.35	0.21	0	0	0.26	0	1.11	0	0	0	0	0.01
R	0.01	2.14	0	0.01	0	0.88	2.93	0.04	0.59	0.5	0.05	0	0.42	3.65	0	0.51	0.19	0	1.77	0
S	0.37	0.5	0	0	0.66	0.88	0.01	0.23	0	1.03	0	1.21	0.68	0	0.64	0	0.73	0	0.06	0.26
T	1.7	0	0.01	0.01	0	0	0	1.45	0.23	0.01	1.71	0.35	0.35	0	0.2	0.87	0	0	0	0
V	1.32	0	0.11	0.13	0.23	0.28	0	3.14	0	1.07	1.97	0	0	0	0	0.01	0	0	0	0
W	0	0.13	0	0	0	0.05	0	0	0	0.06	0	0	0	0.01	0.24	0.03	0	0	0	0
Y	0	0.74	0.07	0	0.16	0.01	0.48	0	0	0.01	0	0.08	0	0	0	0.1	0	0.01	0	0

Frequency matrix of disease-causing mutations (%)

	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	0	0	0.53	0.3	0	0.28	0	0	0	0	0	0	0.3	0	0	1.06	2.91	2.89	0	0
C	0	0	0	0	0.34	0.09	0	0	0	0	0	0	0	0	0.26	0.21	0	0	0.09	0.48
D	0.14	0	0	0.56	0	0.68	0.65	0	0	0	0	2.64	0	0	0	0	0	0.29	0	1.16
E	0.21	0	1.37	0	0	0.61	0	0	4.62	0	0	0	0	1.15	0	0	0	0.33	0	0
F	0	0.22	0	0	0	0	0	0.15	0	0.99	0	0	0	0	0	0.25	0	0.23	0	0.11
G	0.4	0.83	1.12	1.69	0.01	0	0	0	0.03	0.01	0	0.01	0	0	1.84	1.11	0	1.28	0.6	0
H	0	0	0.11	0	0	0	0	0	0	0.13	0	0.39	0.11	0.27	0.38	0	0	0	0	0.84
I	0	0	0	0	0.23	0	0	0	0.04	0.17	0.52	0.2	0	0	0.02	0.14	0.49	0.68	0	0
K	0	0	0	0.53	0	0	0	0.1	0	0	0.18	1.39	0	0.23	0.52	0	0.48	0	0	0
L	0	0	0	0	1.42	0	0.14	0.83	0	0	0.65	0	0.86	0.22	0.38	0.19	0	0.79	0.05	0
M	0	0	0	0	0	0	0	1.04	0.09	0.18	0	0	0	0	0.07	0	0.27	0.38	0	0
N	0	0	0.32	0	0	0	0.18	0.2	0.49	0	0	0	0	0	0	0.68	0.18	0	0	0.15
P	0.36	0	0	0	0.05	0	0.89	0	0	2.92	0	0	0	0.62	0.3	3.14	0.91	0	0	0
Q	0	0	0	0.42	0	0	1.05	0	0.74	0.3	0	0	0.18	0	0.51	0	0	0	0	0
R	0	2.73	0	0	0	0.54	2.61	0.43	0.77	1.05	0.31	0	0.28	2.8	0	0.71	0.31	0	1.98	0
S	0.15	0.72	0	0	2.19	0.36	0	0.46	0	1.57	0	0.76	0.49	0	0.55	0	0.34	0	0.04	0.72
T	0.87	0	0	0	0	0	0	0.99	0.25	0	0.99	0.34	0.25	0	0.12	0.42	0	0	0	0
V	0.86	0	0.12	0.14	0.37	0.29	0	1.23	0	0.77	1.15	0	0	0	0	0	0	0	0	0
W	0	0.32	0	0	0	0.05	0	0	0	0.29	0	0	0	0	0.19	0.05	0	0	0	0
Y	0	0.71	0.08	0	0.17	0	0.42	0	0	0	0	0.14	0	0	0	0.08	0	0	0	0