MPAD: Membrane Protein complex binding Affinity Database

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STATISTICS

  • Summary
  • In Depth

Summary

Number of entries 5376
Number of PDB IDs 800
Number of UniProt IDs 950
Number of organisms 190
Number of articles 676
Publication years 1989-2022

In Depth

Statistics based on mutations



Some more statistics



Distribution of thermodynamic parameters in wild-type and mutants

Parameter Minimum value Maximum value
Wild-type KD (M) 1.58E-14 9.16E-02
Mutant KD (M) 3.40E-14 2.60E-03
Wild-type kon (1/Ms) 8.80E-05 1.22E+08
Mutant kon (1/Ms) 2.30E-03 3.90E+08
Wild-type koff (1/s) 1.69E-09 0.16
Mutant koff (1/s) 5.23E-07 1.39E+03
ΔG wild (kcal/mol) - 23.6 - 1.4
ΔG mutant (kcal/mol) - 24.2 - 3.5
ΔΔG (kcal/mol) - 7.36 7.95
 

Distribution of dissociation constant (KD) and ΔG values in wild-type and mutants




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The database is maintained by Protein Bioinformatics Lab,
Department of Biotechnology, Indian Institute of Technology Madras
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