Database for experimentally known amyloid-forming peptides
Database for experimentally known APRs in amyloidogenic proteins
Database for aggregation kinetic data from various experiments
Database for structures related to aggregating proteins
CPAD 2.0 database contains the following information related to the mechanistic and kinetic aspect of protein aggregation:
(i) Database for amyloid peptides, data on experimentally known amyloid-forming peptides, non-amyloids, their physiochemical features and aggregation propensity.
This database can be accessed by clicking on Amyloid Proteins and Peptide.
(ii) Aggregation-Prone Regions (APRs): Experimentally known hot-spot regions prone to aggregation in amyloidogenic protein.
(iii) Database of experimental data collected from the various aggregation related experiments (such as Thioflavin assay, congo-red assay, etc.) to measure the kinetics of protein aggregation. Click on Aggregation Kinetics to access the database.
(iv) Database for structures of aggregation-related proteins. It contains the amyloidogenic proteins/mutants, their fibril structure and complex with aggregation rate inhibitor/enhancer ligand. Click on Structure of Aggregating Proteins to access the database.
References to related databases and web servers
CPAD 2.0 is an integrated database which contains information related to amyloidogenic proteins, Aggregation prone regions, aggregation kinetics and structure of proteins relevant to aggregation. Authors are encouraged to deposit any information related to above topics to our server.
The template CSV files are provided to fill in the respective detail. Please download the Template files for the respective dataset from here.
If you have used our dataset in your work. Please cite us:
[Citation: coming soon]
Please carefully read the TUTORIAL page before using the database.
An effective method to predict the aggregation-prone region in proteins/peptides.
Several improvements in the user interface. Updated the database.
AggreRATE-Pred can quantitatively predict the change in aggregation rate.
AggreRATE-Disc can predict the aggregation rate enhancer or mitigator mutations using sequence information.