Home
Links
APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Tutorial
Statistics
Download
Contact Us
Home
Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
help
Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
Enter the query text:
help
Select a class:
help
All
Amyloid
Non-Amyloid
Submit
Reset
Max. of 30 records would be displayed in a single page.
Patterns can be used in the search.
«
1
2
3
(current)
4
5
6
7
8
67
68
»
Displaying 61 to 90 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0061
ALQTDA
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0062
AMMAAA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0063
AMNITN
6
Non-amyloid
Nitrogen regulatory protein GLN3
P18494
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0064
ANATKK
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0065
ANFLVH
6
amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
J Phys Chem B. 2016 Jul 7;120(26):5810-6.
26629790
Waltz-DB 2.0
P-0066
ANNNSN
6
Non-amyloid
Nucleoporin NSP1
P14907
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0067
ANNYSS
6
Non-amyloid
Nucleoporin ASM4 (Nuclear pore protein NUP59)
Q05166
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0068
APKPKK
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0069
AQAALQ
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0070
AQAQPA
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0071
AQFIIS
6
Amyloid
transcription factor 1 (POU domain)
P14859
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0
P-0072
AQIVYK
6
non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623A
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0073
AQPAGG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0074
ASNAGS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0075
ASQQNQ
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0076
ASRQNQ
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
Q343R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0077
ASSSNY
6
Amyloid
Ribonuclease (RNase A)
P61823
No
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
20133726
CPAD, Waltz-DB 2.0, AmyLoad
P-0078
ATAHQY
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0079
ATKKVD
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0080
ATLDQW
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0081
ATTRTV
6
Non-amyloid
Agglutinin-like protein 1 (Adhesin 1)
Q5A8T4
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0082
ATVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0083
ATVQAF
6
amyloid
Zona pellucida sperm-binding protein 1
P60852
C280A
PLoS One. 2013 Sep 12;8(9):e73258.
24069181
Waltz-DB 2.0
P-0084
ATVSFD
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0085
AVDQTA
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0086
AVFIIY
6
Amyloid
Abnormal spindle-like microcephaly-associated protein
Q8IZT6
No
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-0087
AVTTGV
6
Non-amyloid
Cell wall adhesin EAP1
G1UBC2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0088
AYNAQA
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0089
CATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38C
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0090
CGVIGI
6
Amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
«
1
2
3
(current)
4
5
6
7
8
67
68
»
<
Entry: P-0061 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0061
Peptide:
ALQTDA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
58-63
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-52.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.77
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0062 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0062
Peptide:
AMMAAA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
321-326
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.4
Area of the profile Above Threshold (AGGRESCAN):
0.84
Best Energy Score (PASTA 2.0):
0.53
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0063 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
D
D
P
E
N
S
K
L
Y
D
L
L
N
S
H
L
D
V
H
G
R
S
N
E
E
P
R
Q
T
G
D
S
R
S
Q
S
S
G
N
T
G
E
N
E
E
D
I
A
F
A
S
G
L
N
G
G
T
F
60
61
D
S
M
L
E
A
L
P
D
D
L
Y
F
T
D
F
V
S
P
F
T
A
A
A
T
T
S
V
T
T
K
T
V
K
D
T
T
P
A
T
N
H
M
D
D
D
I
A
M
F
D
S
L
A
T
T
Q
P
I
D
120
121
I
A
A
S
N
Q
Q
N
G
E
I
A
Q
L
W
D
F
N
V
D
Q
F
N
M
T
P
S
N
S
S
G
S
A
T
I
S
A
P
N
S
F
T
S
D
I
P
Q
Y
N
H
G
S
L
G
N
S
V
S
K
S
180
181
S
L
F
P
Y
N
S
S
T
S
N
S
N
I
N
Q
P
S
I
N
N
N
S
N
T
N
A
Q
S
H
H
S
F
N
I
Y
K
L
Q
N
N
N
S
S
S
S
A
M
N
I
T
N
N
N
N
S
N
N
S
N
240
241
I
Q
H
P
F
L
K
K
S
D
S
I
G
L
S
S
S
N
T
T
N
S
V
R
K
N
S
L
I
K
P
M
S
S
T
S
L
A
N
F
K
R
A
A
S
V
S
S
S
I
S
N
M
E
P
S
G
Q
N
K
300
301
K
P
L
I
Q
C
F
N
C
K
T
F
K
T
P
L
W
R
R
S
P
E
G
N
T
L
C
N
A
C
G
L
F
Q
K
L
H
G
T
M
R
P
L
S
L
K
S
D
V
I
K
K
R
I
S
K
K
R
A
K
360
361
Q
T
D
P
N
I
A
Q
N
T
P
S
A
P
A
T
A
S
T
S
V
T
T
T
N
A
K
P
I
R
S
R
K
K
S
L
Q
Q
N
S
L
S
R
V
I
P
E
E
I
I
R
D
N
I
G
N
T
N
N
I
420
421
L
N
V
N
R
G
G
Y
N
F
N
S
V
P
S
P
V
L
M
N
S
Q
S
Y
N
S
S
N
A
N
F
N
G
A
S
N
A
N
L
N
S
N
N
L
M
R
H
N
S
N
T
V
T
P
N
F
R
R
S
S
480
481
R
R
S
S
T
S
S
N
T
S
S
S
S
K
S
S
S
R
S
V
V
P
I
L
P
K
P
S
P
N
S
A
N
S
Q
Q
F
N
M
N
M
N
L
M
N
T
T
N
N
V
S
A
G
N
S
V
A
S
S
P
540
541
R
I
I
S
S
A
N
F
N
S
N
S
P
L
Q
Q
N
L
L
S
N
S
F
Q
R
Q
G
M
N
I
P
R
R
K
M
S
R
N
A
S
Y
S
S
S
F
M
A
A
S
L
Q
Q
L
H
E
Q
Q
Q
V
D
600
601
V
N
S
N
T
N
T
N
S
N
R
Q
N
W
N
S
S
N
S
V
S
T
N
S
R
S
S
N
F
V
S
Q
K
P
N
F
D
I
F
N
T
P
V
D
S
P
S
V
S
R
P
S
S
R
K
S
H
T
S
L
660
661
L
S
Q
Q
L
Q
N
S
E
S
N
S
F
I
S
N
H
K
F
N
N
R
L
S
S
D
S
T
S
P
I
K
Y
E
A
D
V
S
A
G
G
K
I
S
E
D
N
S
T
K
G
S
S
K
E
S
S
A
I
A
720
721
D
E
L
D
W
L
K
F
G
I
730
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0063
Peptide:
AMNITN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P18494
UniProt Name:
GLN3_YEAST
Protein Name:
Nitrogen regulatory protein GLN3
Position:
227-232
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.0
Area of the profile Above Threshold (AGGRESCAN):
0.28
Best Energy Score (PASTA 2.0):
-2.21
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0064 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0064
Peptide:
ANATKK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
155-160
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.94
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0065 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0065
Peptide:
ANFLVH
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
46-51
Literature
PMID:
26629790
Reference:
J Phys Chem B. 2016 Jul 7;120(26):5810-6.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
37.8
Area of the profile Above Threshold (AGGRESCAN):
2.42
Best Energy Score (PASTA 2.0):
-3.63
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0066 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
F
N
T
P
Q
Q
N
K
T
P
F
S
F
G
T
A
N
N
N
S
N
T
T
N
Q
N
S
S
T
G
A
G
A
F
G
T
G
Q
S
T
F
G
F
N
N
S
A
P
N
N
T
N
N
A
N
S
S
I
60
61
T
P
A
F
G
S
N
N
T
G
N
T
A
F
G
N
S
N
P
T
S
N
V
F
G
S
N
N
S
T
T
N
T
F
G
S
N
S
A
G
T
S
L
F
G
S
S
S
A
Q
Q
T
K
S
N
G
T
A
G
G
120
121
N
T
F
G
S
S
S
L
F
N
N
S
T
N
S
N
T
T
K
P
A
F
G
G
L
N
F
G
G
G
N
N
T
T
P
S
S
T
G
N
A
N
T
S
N
N
L
F
G
A
T
A
N
A
N
K
P
A
F
S
180
181
F
G
A
T
T
N
D
D
K
K
T
E
P
D
K
P
A
F
S
F
N
S
S
V
G
N
K
T
D
A
Q
A
P
T
T
G
F
S
F
G
S
Q
L
G
G
N
K
T
V
N
E
A
A
K
P
S
L
S
F
G
240
241
S
G
S
A
G
A
N
P
A
G
A
S
Q
P
E
P
T
T
N
E
P
A
K
P
A
L
S
F
G
T
A
T
S
D
N
K
T
T
N
T
T
P
S
F
S
F
G
A
K
S
D
E
N
K
A
G
A
T
S
K
300
301
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
360
361
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
P
D
E
N
K
A
S
A
T
S
K
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
420
421
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
S
480
481
D
E
K
K
D
S
D
S
S
K
P
A
F
S
F
G
T
K
S
N
E
K
K
D
S
G
S
S
K
P
A
F
S
F
G
A
K
P
D
E
K
K
N
D
E
V
S
K
P
A
F
S
F
G
A
K
A
N
E
K
540
541
K
E
S
D
E
S
K
S
A
F
S
F
G
S
K
P
T
G
K
E
E
G
D
G
A
K
A
A
I
S
F
G
A
K
P
E
E
Q
K
S
S
D
T
S
K
P
A
F
T
F
G
A
Q
K
D
N
E
K
K
T
600
601
E
E
S
S
T
G
K
S
T
A
D
V
K
S
S
D
S
L
K
L
N
S
K
P
V
E
L
K
P
V
S
L
D
N
K
T
L
D
D
L
V
T
K
W
T
N
Q
L
T
E
S
A
S
H
F
E
Q
Y
T
K
660
661
K
I
N
S
W
D
Q
V
L
V
K
G
G
E
Q
I
S
Q
L
Y
S
D
A
V
M
A
E
H
S
Q
N
K
I
D
Q
S
L
Q
Y
I
E
R
Q
Q
D
E
L
E
N
F
L
D
N
F
E
T
K
T
E
A
720
721
L
L
S
D
V
V
S
T
S
S
G
A
A
A
N
N
N
D
Q
K
R
Q
Q
A
Y
K
T
A
Q
T
L
D
E
N
L
N
S
L
S
S
N
L
S
S
L
I
V
E
I
N
N
V
S
N
T
F
N
K
T
T
780
781
N
I
D
I
N
N
E
D
E
N
I
Q
L
I
K
I
L
N
S
H
F
D
A
L
R
S
L
D
D
N
S
T
S
L
E
K
Q
I
N
S
I
K
K
823
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0066
Peptide:
ANNNSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14907
UniProt Name:
NSP1_YEAST
Protein Name:
Nucleoporin NSP1
Position:
18-23
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-104.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.57
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0067 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
F
G
I
R
S
G
N
N
N
G
G
F
T
N
L
T
S
Q
A
P
Q
T
T
Q
M
F
Q
S
Q
S
Q
L
Q
P
Q
P
Q
P
Q
P
Q
Q
Q
Q
Q
H
L
Q
F
N
G
S
S
D
A
S
S
L
R
60
61
F
G
N
S
L
S
N
T
V
N
A
N
N
Y
S
S
N
I
G
N
N
S
I
N
N
N
N
I
K
N
G
T
N
N
I
S
Q
H
G
Q
G
N
N
P
S
W
V
N
N
P
K
K
R
F
T
P
H
T
V
I
120
121
R
R
K
T
T
K
Q
N
S
S
S
D
I
N
Q
N
D
D
S
S
S
M
N
A
T
M
R
N
F
S
K
Q
N
Q
D
S
K
H
N
E
R
N
K
S
A
A
N
N
D
I
N
S
L
L
S
N
F
N
D
I
180
181
P
P
S
V
T
L
Q
D
W
Q
R
E
D
E
F
G
S
I
P
S
L
T
T
Q
F
V
T
D
K
Y
T
A
K
K
T
N
R
S
A
Y
D
S
K
N
T
P
N
V
F
D
K
D
S
Y
V
R
I
A
N
I
240
241
E
Q
N
H
L
D
N
N
Y
N
T
A
E
T
N
N
K
V
H
E
T
S
S
K
S
S
S
L
S
A
I
I
V
F
G
Y
P
E
S
I
S
N
E
L
I
E
H
F
S
H
F
G
H
I
M
E
D
F
Q
V
300
301
L
R
L
G
R
G
I
N
P
N
T
F
R
I
F
H
N
H
D
T
G
C
D
E
N
D
S
T
V
N
K
S
I
T
L
K
G
R
N
N
E
S
N
N
K
K
Y
P
I
F
T
G
E
S
W
V
K
L
T
Y
360
361
N
S
P
S
S
A
L
R
A
L
Q
E
N
G
T
I
F
R
G
S
L
I
G
C
I
P
Y
S
K
N
A
V
E
Q
L
A
G
C
K
I
D
N
V
D
D
I
G
E
F
N
V
S
M
Y
Q
N
S
S
T
S
420
421
S
T
S
N
T
P
S
P
P
N
V
I
I
T
D
G
T
L
L
R
E
D
D
N
T
P
A
G
H
A
G
N
P
T
N
I
S
S
P
I
V
A
N
S
P
N
K
R
L
D
V
I
D
G
K
L
P
F
M
Q
480
481
N
A
G
P
N
S
N
I
P
N
L
L
R
N
L
E
S
K
M
R
Q
Q
E
A
K
Y
R
N
N
E
P
A
G
F
T
H
K
L
S
N
W
L
F
G
W
N
D
L
528
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0067
Peptide:
ANNYSS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q05166
UniProt Name:
NUP59_YEAST
Protein Name:
Nucleoporin ASM4 (Nuclear pore protein NUP59)
Position:
71-76
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.37
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-45.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0068 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0068
Peptide:
APKPKK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
137-142
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
3
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-69.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
4.69
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0069 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0069
Peptide:
AQAALQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
326-331
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.2
Area of the profile Above Threshold (AGGRESCAN):
0.03
Best Energy Score (PASTA 2.0):
1.24
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0070 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0070
Peptide:
AQAQPA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
37-42
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-65.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.94
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0071 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
N
N
P
S
E
T
S
K
P
S
M
E
S
G
D
G
N
T
G
T
Q
T
N
G
L
D
F
Q
K
Q
P
V
P
V
G
G
A
I
S
T
A
Q
A
Q
A
F
L
G
H
L
H
Q
V
Q
L
A
G
T
S
60
61
L
Q
A
A
A
Q
S
L
N
V
Q
S
K
S
N
E
E
S
G
D
S
Q
Q
P
S
Q
P
S
Q
Q
P
S
V
Q
A
A
I
P
Q
T
Q
L
M
L
A
G
G
Q
I
T
G
L
T
L
T
P
A
Q
Q
Q
120
121
L
L
L
Q
Q
A
Q
A
Q
A
Q
L
L
A
A
A
V
Q
Q
H
S
A
S
Q
Q
H
S
A
A
G
A
T
I
S
A
S
A
A
T
P
M
T
Q
I
P
L
S
Q
P
I
Q
I
A
Q
D
L
Q
Q
L
Q
180
181
Q
L
Q
Q
Q
N
L
N
L
Q
Q
F
V
L
V
H
P
T
T
N
L
Q
P
A
Q
F
I
I
S
Q
T
P
Q
G
Q
Q
G
L
L
Q
A
Q
N
L
L
T
Q
L
P
Q
Q
S
Q
A
N
L
L
Q
S
Q
240
241
P
S
I
T
L
T
S
Q
P
A
T
P
T
R
T
I
A
A
T
P
I
Q
T
L
P
Q
S
Q
S
T
P
K
R
I
D
T
P
S
L
E
E
P
S
D
L
E
E
L
E
Q
F
A
K
T
F
K
Q
R
R
I
300
301
K
L
G
F
T
Q
G
D
V
G
L
A
M
G
K
L
Y
G
N
D
F
S
Q
T
T
I
S
R
F
E
A
L
N
L
S
F
K
N
M
C
K
L
K
P
L
L
E
K
W
L
N
D
A
E
N
L
S
S
D
S
360
361
S
L
S
S
P
S
A
L
N
S
P
G
I
E
G
L
S
R
R
R
K
K
R
T
S
I
E
T
N
I
R
V
A
L
E
K
S
F
L
E
N
Q
K
P
T
S
E
E
I
T
M
I
A
D
Q
L
N
M
E
K
420
421
E
V
I
R
V
W
F
C
N
R
R
Q
K
E
K
R
I
N
P
P
S
S
G
G
T
S
S
S
P
I
K
A
I
F
P
S
P
T
S
L
V
A
T
T
P
S
L
V
T
S
S
A
A
T
T
L
T
V
S
P
480
481
V
L
P
L
T
S
A
A
V
T
N
L
S
V
T
G
T
S
D
T
T
S
N
N
T
A
T
V
I
S
T
A
P
P
A
S
S
A
V
T
S
P
S
L
S
P
S
P
S
A
S
A
S
T
S
E
A
S
S
A
540
541
S
E
T
S
T
T
Q
T
T
S
T
P
L
S
S
P
L
G
T
S
Q
V
M
V
T
A
S
G
L
Q
T
A
A
A
A
A
L
Q
G
A
A
Q
L
P
A
N
A
S
L
A
A
M
A
A
A
A
G
L
N
P
600
601
S
L
M
A
P
S
Q
F
A
A
G
G
A
L
L
S
L
N
P
G
T
L
S
G
A
L
S
P
A
L
M
S
N
S
T
L
A
T
I
Q
A
L
A
S
G
G
S
L
P
I
T
S
L
D
A
T
G
N
L
V
660
661
F
A
N
A
G
G
A
P
N
I
V
T
A
P
L
F
L
N
P
Q
N
L
S
L
L
T
S
N
P
V
S
L
V
S
A
A
A
A
S
A
G
N
S
A
P
V
A
S
L
H
A
T
S
T
S
A
E
S
I
Q
720
721
N
S
L
F
T
V
A
S
A
S
G
A
A
S
T
T
T
T
A
S
K
A
Q
743
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0071
Peptide:
AQFIIS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14859
UniProt Name:
PO2F1_HUMAN
Protein Name:
transcription factor 1 (POU domain)
Position:
204-209
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.88
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
58.0
Area of the profile Above Threshold (AGGRESCAN):
3.68
Best Energy Score (PASTA 2.0):
-4.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0072 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0072
Peptide:
AQIVYK
Length:
6
Classification:
non-amyloid
Mutation(s):
V623A
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
39.6
Area of the profile Above Threshold (AGGRESCAN):
2.56
Best Energy Score (PASTA 2.0):
-3.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0073 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0073
Peptide:
AQPAGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
39-44
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
4.32
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0074 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0074
Peptide:
ASNAGS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
388-393
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-59.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0075 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0075
Peptide:
ASQQNQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
341-346
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-101.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.23
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0076 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0076
Peptide:
ASRQNQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
Q343R
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
341-346
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-101.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.91
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0077 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
K
S
L
V
L
L
S
L
L
V
L
V
L
L
L
V
R
V
Q
P
S
L
G
K
E
T
A
A
A
K
F
E
R
Q
H
M
D
S
S
T
S
A
A
S
S
S
N
Y
C
N
Q
M
M
K
S
R
N
60
61
L
T
K
D
R
C
K
P
V
N
T
F
V
H
E
S
L
A
D
V
Q
A
V
C
S
Q
K
N
V
A
C
K
N
G
Q
T
N
C
Y
Q
S
Y
S
T
M
S
I
T
D
C
R
E
T
G
S
S
K
Y
P
N
120
121
C
A
Y
K
T
T
Q
A
N
K
H
I
I
V
A
C
E
G
N
P
Y
V
P
V
H
F
D
A
S
V
150
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0077
Peptide:
ASSSNY
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61823
UniProt Name:
RNAS1_BOVIN
Protein Name:
Ribonuclease (RNase A)
Position:
46-51
Literature
PMID:
20133726
Reference:
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-39.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.65
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0078 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0078
Peptide:
ATAHQY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
146-151
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-46.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.25
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0079 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0079
Peptide:
ATKKVD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
33.33
NuAPRpred:
-0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.36
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0080 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0080
Peptide:
ATLDQW
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
101-106
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-35.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.62
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0081 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
Q
Q
F
T
L
L
F
L
Y
L
S
I
A
S
A
K
T
I
T
G
V
F
D
S
F
N
S
L
T
W
S
N
A
A
N
Y
A
F
K
G
P
G
Y
P
T
W
N
A
V
L
G
W
S
L
D
G
T
S
60
61
A
N
P
G
D
T
F
T
L
N
M
P
C
V
F
K
Y
T
T
S
Q
T
S
V
D
L
T
A
D
G
V
K
Y
A
T
C
Q
F
Y
S
G
E
E
F
T
T
F
S
T
L
T
C
T
V
N
D
A
L
K
S
120
121
S
I
K
A
F
G
T
V
T
L
P
I
A
F
N
V
G
G
T
G
S
S
T
D
L
E
D
S
K
C
F
T
A
G
T
N
T
V
T
F
N
D
G
D
K
D
I
S
I
D
V
E
F
E
K
S
T
V
D
P
180
181
S
G
Y
L
Y
A
S
R
V
M
P
S
L
N
K
V
T
T
L
F
V
A
P
Q
C
E
N
G
Y
T
S
G
T
M
G
F
S
S
S
N
G
D
V
A
I
D
C
S
N
I
H
I
G
I
T
K
G
L
N
D
240
241
W
N
Y
P
V
S
S
E
S
F
S
Y
T
K
T
C
T
S
N
G
I
Q
I
K
Y
Q
N
V
P
A
G
Y
R
P
F
I
D
A
Y
I
S
A
T
D
V
N
Q
Y
T
L
A
Y
T
N
D
Y
T
C
A
G
300
301
S
R
S
Q
S
K
P
F
T
L
R
W
T
G
Y
K
N
S
D
A
G
S
N
G
I
V
I
V
A
T
T
R
T
V
T
D
S
T
T
A
V
T
T
L
P
F
N
P
S
V
D
K
T
K
T
I
E
I
L
Q
360
361
P
I
P
T
T
T
I
T
T
S
Y
V
G
V
T
T
S
Y
S
T
K
T
A
P
I
G
E
T
A
T
V
I
V
D
V
P
Y
H
T
T
T
T
V
T
S
E
W
T
G
T
I
T
T
T
T
T
R
T
N
P
420
421
T
D
S
I
D
T
V
V
V
Q
V
P
S
P
N
P
T
V
S
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
480
481
S
Q
S
F
A
T
T
T
T
V
T
A
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
540
541
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
I
T
A
600
601
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
660
661
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
720
721
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
F
A
T
T
T
T
V
T
A
780
781
P
P
G
G
T
D
T
V
I
I
Y
E
S
M
S
S
S
K
I
S
T
S
S
N
D
I
T
S
I
I
P
S
F
S
R
P
H
Y
V
N
S
T
T
S
D
L
S
T
F
E
S
S
S
M
N
T
P
T
S
I
840
841
S
S
D
G
M
L
L
S
S
T
T
L
V
T
E
S
E
T
T
T
E
S
I
C
S
D
G
K
E
C
S
R
L
S
S
S
S
G
I
V
T
N
P
D
S
N
E
S
S
I
V
T
S
T
V
P
T
A
S
T
900
901
M
S
D
S
L
S
S
T
D
G
I
S
A
T
S
S
D
N
V
S
K
S
G
V
S
V
T
T
E
T
S
V
T
T
I
Q
T
T
P
N
P
L
S
S
S
V
T
S
L
T
Q
L
S
S
I
P
S
V
S
E
960
961
S
E
S
K
V
T
F
T
S
N
G
D
N
Q
S
G
T
H
D
S
Q
S
T
S
T
E
I
E
I
V
T
T
S
S
T
K
V
L
P
P
V
V
S
S
N
T
D
L
T
S
E
P
T
N
T
R
E
Q
P
T
1020
1021
T
L
S
T
T
S
N
S
I
T
E
D
I
T
T
S
Q
P
T
G
D
N
G
D
N
T
S
S
T
N
P
V
P
T
V
A
T
S
T
L
A
S
A
S
E
E
D
N
K
S
G
S
H
E
S
A
S
T
S
L
1080
1081
K
P
S
M
G
E
N
S
G
L
T
T
S
T
E
I
E
A
T
T
T
S
P
T
E
A
P
S
P
A
V
S
S
G
T
D
V
T
T
E
P
T
D
T
R
E
Q
P
T
T
L
S
T
T
S
K
T
N
S
E
1140
1141
S
V
A
T
T
Q
A
T
N
E
N
G
G
K
S
P
S
T
D
L
T
S
S
L
T
T
G
T
S
A
S
T
S
A
N
S
E
L
V
T
S
G
S
V
T
G
G
A
V
A
S
A
S
N
D
Q
S
H
S
T
1200
1201
S
V
T
N
S
N
S
I
V
S
N
T
P
Q
T
T
L
S
Q
Q
V
T
S
S
S
P
S
T
N
T
F
I
A
S
T
Y
D
G
S
G
S
I
I
Q
H
S
T
W
L
Y
G
L
I
T
L
L
S
L
F
I
1260
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0081
Peptide:
ATTRTV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q5A8T4
UniProt Name:
ALS1_CANAL
Protein Name:
Agglutinin-like protein 1 (Adhesin 1)
Position:
329-334
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-34.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-2.41
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0082 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0082
Peptide:
ATVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.83
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
58.0
Area of the profile Above Threshold (AGGRESCAN):
3.77
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0083 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
G
S
A
T
T
W
G
Y
P
V
A
L
L
L
L
V
A
T
L
G
L
G
R
W
L
Q
P
D
P
G
L
P
G
L
R
H
S
Y
D
C
G
I
K
G
M
Q
L
L
V
F
P
R
P
G
Q
T
L
60
61
R
F
K
V
V
D
E
F
G
N
R
F
D
V
N
N
C
S
I
C
Y
H
W
V
T
S
R
P
Q
E
P
A
V
F
S
A
D
Y
R
G
C
H
V
L
E
K
D
G
R
F
H
L
R
V
F
M
E
A
V
L
120
121
P
N
G
R
V
D
V
A
Q
D
A
T
L
I
C
P
K
P
D
P
S
R
T
L
D
S
Q
L
A
P
P
A
M
F
S
V
S
T
P
Q
T
L
S
F
L
P
T
S
G
H
T
S
Q
G
S
G
H
A
F
P
180
181
S
P
L
D
P
G
H
S
S
V
H
P
T
P
A
L
P
S
P
G
P
G
P
T
L
A
T
L
A
Q
P
H
W
G
T
L
E
H
W
D
V
N
K
R
D
Y
I
G
T
H
L
S
Q
E
Q
C
Q
V
A
S
240
241
G
H
L
P
C
I
V
R
R
T
S
K
E
A
C
Q
Q
A
G
C
C
Y
D
N
T
R
E
V
P
C
Y
Y
G
N
T
A
T
V
Q
C
F
R
D
G
Y
F
V
L
V
V
S
Q
E
M
A
L
T
H
R
I
300
301
T
L
A
N
I
H
L
A
Y
A
P
T
S
C
S
P
T
Q
H
T
E
A
F
V
V
F
Y
F
P
L
T
H
C
G
T
T
M
Q
V
A
G
D
Q
L
I
Y
E
N
W
L
V
S
G
I
H
I
Q
K
G
P
360
361
Q
G
S
I
T
R
D
S
T
F
Q
L
H
V
R
C
V
F
N
A
S
D
F
L
P
I
Q
A
S
I
F
P
P
P
S
P
A
P
M
T
Q
P
G
P
L
R
L
E
L
R
I
A
K
D
E
T
F
S
S
Y
420
421
Y
G
E
D
D
Y
P
I
V
R
L
L
R
E
P
V
H
V
E
V
R
L
L
Q
R
T
D
P
N
L
V
L
L
L
H
Q
C
W
G
A
P
S
A
N
P
F
Q
Q
P
Q
W
P
I
L
S
D
G
C
P
F
480
481
K
G
D
S
Y
R
T
Q
M
V
A
L
D
G
A
T
P
F
Q
S
H
Y
Q
R
F
T
V
A
T
F
A
L
L
D
S
G
S
Q
R
A
L
R
G
L
V
Y
L
F
C
S
T
S
A
C
H
T
S
G
L
E
540
541
T
C
S
T
A
C
S
T
G
T
T
R
Q
R
R
S
S
G
H
R
N
D
T
A
R
P
Q
D
I
V
S
S
P
G
P
V
G
F
E
D
S
Y
G
Q
E
P
T
L
G
P
T
D
S
N
G
N
S
S
L
R
600
601
P
L
L
W
A
V
L
L
L
P
A
V
A
L
V
L
G
F
G
V
F
V
G
L
S
Q
T
W
A
Q
K
L
W
E
S
N
R
Q
638
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0083
Peptide:
ATVQAF
Length:
6
Classification:
amyloid
Mutation(s):
C280A
Structure(s):
No structures
Protein Information
UniProt ID:
P60852
UniProt Name:
ZP1_HUMAN
Protein Name:
Zona pellucida sperm-binding protein 1
Position:
276-281
Literature
PMID:
24069181
Reference:
PLoS One. 2013 Sep 12;8(9):e73258.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.8
Area of the profile Above Threshold (AGGRESCAN):
0.89
Best Energy Score (PASTA 2.0):
-1.08
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0084 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0084
Peptide:
ATVSFD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
337-342
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.31
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.5
Area of the profile Above Threshold (AGGRESCAN):
0.92
Best Energy Score (PASTA 2.0):
-2.31
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0085 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0085
Peptide:
AVDQTA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
125-130
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.6
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0086 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
A
V
F
I
I
Y
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0086
Peptide:
AVFIIY
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8IZT6
UniProt Name:
ASPM_HUMAN
Protein Name:
Abnormal spindle-like microcephaly-associated protein
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.06
Tango:
219.84
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
110.2
Area of the profile Above Threshold (AGGRESCAN):
7.09
Best Energy Score (PASTA 2.0):
-7.27
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0087 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
S
Q
I
L
P
L
A
G
A
I
S
V
A
S
G
F
W
I
P
D
F
S
N
K
Q
N
S
N
S
Y
P
G
Q
Y
K
G
K
G
G
Y
Q
D
D
C
G
D
D
Y
K
K
G
Y
K
S
K
T
Y
60
61
S
K
V
K
P
I
T
S
T
D
C
T
T
P
I
Q
P
T
G
T
T
T
G
Y
T
K
D
V
V
E
S
T
S
Y
T
T
D
T
A
Y
T
T
T
V
I
T
V
T
K
C
D
G
G
S
C
S
H
T
A
V
120
121
T
T
G
V
T
I
I
T
V
T
T
N
D
V
I
T
E
Y
T
T
Y
C
P
L
T
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
180
181
E
S
T
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
240
241
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
A
S
T
E
T
A
S
S
T
P
V
E
S
T
V
I
V
P
S
T
T
V
I
T
V
S
S
C
Y
E
D
K
C
S
V
S
S
V
T
T
G
V
V
T
I
300
301
S
S
E
E
T
I
Y
T
T
Y
C
P
I
T
S
S
I
T
I
P
V
P
N
T
S
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
360
361
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
420
421
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
A
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
480
481
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
S
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
G
T
E
A
T
P
V
T
T
Q
P
540
541
V
S
V
L
S
T
S
Q
V
V
T
A
S
G
E
F
S
T
V
T
A
H
S
T
S
I
V
A
S
C
P
E
G
G
C
V
P
E
G
Q
Q
T
E
T
S
P
S
V
P
T
N
G
P
E
V
E
A
S
S
S
600
601
V
L
S
I
P
V
S
S
V
T
T
S
T
I
A
S
S
S
E
T
S
V
P
P
A
Q
V
S
T
F
E
G
S
G
S
A
L
K
K
P
Y
Y
G
L
A
V
A
A
L
V
Y
F
M
653
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0087
Peptide:
AVTTGV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
G1UBC2
UniProt Name:
G1UBC2_CANAL
Protein Name:
Cell wall adhesin EAP1
Position:
119-124
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.09
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.3
Area of the profile Above Threshold (AGGRESCAN):
0.65
Best Energy Score (PASTA 2.0):
-2.83
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0088 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0088
Peptide:
AYNAQA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
34-39
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.33
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-46.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0089 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0089
Peptide:
CATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38C
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.94
Tango:
1.6
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
47.6
Area of the profile Above Threshold (AGGRESCAN):
3.02
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0090 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0090
Peptide:
CGVIGI
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
147-152
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
1.07
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
60.3
Area of the profile Above Threshold (AGGRESCAN):
3.93
Best Energy Score (PASTA 2.0):
-4.61
Aggregate Orientation (PASTA 2.0):
Parallel
