Home
Links
APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Tutorial
Statistics
Download
Contact Us
Home
Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
help
Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
Enter the query text:
help
Select a class:
help
All
Amyloid
Non-Amyloid
Submit
Reset
Max. of 30 records would be displayed in a single page.
Patterns can be used in the search.
«
1
2
63
64
65
66
67
68
(current)
»
Displaying 2011 to 2031 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-2011
DAEFRHDSGYEVHHQKLVFFAEDVGSNDGAIIGLLVGFVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
G709F, K699D, M706L
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
16293696
CPAD
P-2012
DAEFRHDSGYEVHHQKLVFFAEDVGSNDGAIIGLLVGGVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
K699D
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
16293696
CPAD
P-2013
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLLVGGVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
M706L
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
16293696
CPAD
P-2014
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-2015
DAEFRHDSGYEVHHQKLVFFAEKVGSNDGAIIGLLVGGVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
D694V, K699D, M706L
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD
P-2016
DAEFRHDSGYEVHHQKLVFFAEKVGSNKGAIIGLLVGGVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
K694D, M706L
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD
P-2017
DAEFRHDSGYEVHHQKLVGFAEDVGSNKGAIIGLLVGFVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
F690G, G709F
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD
P-2018
DAEFRHDSGYEVHHQKLVGFAEDVGSNKGAIIGLLVGGVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
F690G, M706L
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD
P-2019
NLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVE
43
Amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
CPAD, AmyLoad
P-2020
MEGLFNAIKDTVTAAINNDGAKLGTSIVSIVENGVGLLGKLFGF
44
Amyloid
CPAD
P-2021
MTGLAEAIANTVQAAQQHDSVKLGTSIVDIVANGVGLLGKLFGF
44
Amyloid
CPAD
P-2022
KKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKK
48
Amyloid
Nat Cell Biol. 2009 Feb;11(2):219-25.
19151706
CPAD
P-2023
QINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNA
51
Amyloid
Lysozyme C
P00698
No
J Mol Biol. 2004 Jul 23;340(5):1153-65.
15236974
CPAD
P-2024
SYGGEGIGNVAVAGELPVAGKTAVAGRVPIIGAVGFGGPAGAAGAVSIAGR
51
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-2025
GSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSD
53
Amyloid
Lysozyme C
P19849
No
J Mol Biol. 2004 Jul 23;340(5):1153-65.
15236974
AmyLoad
P-2026
GQGGGTHNQWNKPSKPKTNMKHMAGAAAAGAVVGGLGYMLGSAMSRPMMHFGNDW
55
Amyloid
Major prion protein (PrP)
P04273
[del]126G
J Mol Biol. 1995 Sep 29;252(4):412-22.
7563061
CPAD
P-2027
GQGGGTHNQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPMMHFGNDW
56
Amyloid
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
P-2028
GQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYE
65
Amyloid
Major prion protein (PrP)
P04156
No
Biochemistry. 2006 May 30;45(21):6724-32.
16716083
CPAD
P-2029
MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPKK
71
Amyloid
Biophys J. 2011 May 18;100(10):2504-12.
21575585
CPAD
P-2030
GKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQ
79
Amyloid
Alpha-synuclein
P37840
No
J Biol Chem. 2002 May 24;277(21):19213-9.
11893734
AmyLoad
P-2031
DEPPQSPWDRVKDLATVYVDVLKDSRRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLR
83
Amyloid
Apolipoprotein C-II (ApoC-II)
P02655
Biochem Biophys Res Commun. 1988 Oct 31;156(2):762-8.
3142462
AmyLoad
«
1
2
63
64
65
66
67
68
(current)
»
<
Entry: P-2011 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2011
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNDGAIIGLLVGFVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
G709F, K699D, M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16293696
Reference:
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
source:
CPAD
Derived Information
Net Charge:
-5
Absolute Charge:
9
Hydrophobicity:
50.0
NuAPRpred:
4.49
Tango:
1526.06
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.8
Area of the profile Above Threshold (AGGRESCAN):
16.43
Best Energy Score (PASTA 2.0):
-11.66
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2012 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2012
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNDGAIIGLLVGGVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
K699D
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16293696
Reference:
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
source:
CPAD
Derived Information
Net Charge:
-5
Absolute Charge:
9
Hydrophobicity:
47.62
NuAPRpred:
3.7
Tango:
1481.1
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.3
Area of the profile Above Threshold (AGGRESCAN):
14.14
Best Energy Score (PASTA 2.0):
-9.44
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2013 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2013
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLLVGGVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16293696
Reference:
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.62
NuAPRpred:
3.45
Tango:
1595.74
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.5
Area of the profile Above Threshold (AGGRESCAN):
14.32
Best Energy Score (PASTA 2.0):
-9.44
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2014 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2014
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.62
NuAPRpred:
1.78
Tango:
1580.53
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.4
Area of the profile Above Threshold (AGGRESCAN):
13.85
Best Energy Score (PASTA 2.0):
-8.86
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2015 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2015
Peptide:
DAEFRHDSGYEVHHQKLVFFAEKVGSNDGAIIGLLVGGVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
D694V, K699D, M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.62
NuAPRpred:
4.76
Tango:
1485.66
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.5
Area of the profile Above Threshold (AGGRESCAN):
14.5
Best Energy Score (PASTA 2.0):
-9.44
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2016 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2016
Peptide:
DAEFRHDSGYEVHHQKLVFFAEKVGSNKGAIIGLLVGGVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
K694D, M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
9
Hydrophobicity:
47.62
NuAPRpred:
4.82
Tango:
1599.78
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.7
Area of the profile Above Threshold (AGGRESCAN):
14.68
Best Energy Score (PASTA 2.0):
-9.44
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2017 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2017
Peptide:
DAEFRHDSGYEVHHQKLVGFAEDVGSNKGAIIGLLVGFVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
F690G, G709F
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.62
NuAPRpred:
2.01
Tango:
1198.13
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.5
Area of the profile Above Threshold (AGGRESCAN):
14.71
Best Energy Score (PASTA 2.0):
-11.66
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2018 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2018
Peptide:
DAEFRHDSGYEVHHQKLVGFAEDVGSNKGAIIGLLVGGVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
F690G, M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.24
NuAPRpred:
1.22
Tango:
1184.44
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.0
Area of the profile Above Threshold (AGGRESCAN):
12.42
Best Energy Score (PASTA 2.0):
-9.44
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2019 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-2019
Peptide:
NLKHQPGGGKVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVE
Length:
43
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
4
Absolute Charge:
8
Hydrophobicity:
34.88
NuAPRpred:
-9.14
Tango:
14.07
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.5
Area of the profile Above Threshold (AGGRESCAN):
4.76
Best Energy Score (PASTA 2.0):
-4.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2020 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-2020
Peptide:
MEGLFNAIKDTVTAAINNDGAKLGTSIVSIVENGVGLLGKLFGF
Length:
44
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
7
Hydrophobicity:
47.73
NuAPRpred:
0.83
Tango:
341.76
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.8
Area of the profile Above Threshold (AGGRESCAN):
12.64
Best Energy Score (PASTA 2.0):
-7.29
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2021 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-2021
Peptide:
MTGLAEAIANTVQAAQQHDSVKLGTSIVDIVANGVGLLGKLFGF
Length:
44
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
50.0
NuAPRpred:
-0.55
Tango:
42.12
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.3
Area of the profile Above Threshold (AGGRESCAN):
11.25
Best Energy Score (PASTA 2.0):
-6.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2022 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-2022
Peptide:
KKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKK
Length:
48
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
19151706
Reference:
Nat Cell Biol. 2009 Feb;11(2):219-25.
source:
CPAD
Derived Information
Net Charge:
4
Absolute Charge:
4
Hydrophobicity:
0.0
NuAPRpred:
-3.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-121.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.04
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-2023 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
S
L
L
I
L
V
L
C
F
L
P
L
A
A
L
G
K
V
F
G
R
C
E
L
A
A
A
M
K
R
H
G
L
D
N
Y
R
G
Y
S
L
G
N
W
V
C
A
A
K
F
E
S
N
F
N
T
Q
A
60
61
T
N
R
N
T
D
G
S
T
D
Y
G
I
L
Q
I
N
S
R
W
W
C
N
D
G
R
T
P
G
S
R
N
L
C
N
I
P
C
S
A
L
L
S
S
D
I
T
A
S
V
N
C
A
K
K
I
V
S
D
G
120
121
N
G
M
N
A
W
V
A
W
R
N
R
C
K
G
T
D
V
Q
A
W
I
R
G
C
R
L
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2023
Peptide:
QINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNA
Length:
51
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00698
UniProt Name:
LYSC_CHICK
Protein Name:
Lysozyme C
Position:
75-125
Literature
PMID:
15236974
Reference:
J Mol Biol. 2004 Jul 23;340(5):1153-65.
source:
CPAD
Derived Information
Net Charge:
2
Absolute Charge:
8
Hydrophobicity:
43.14
NuAPRpred:
-5.31
Tango:
1.09
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-14.9
Area of the profile Above Threshold (AGGRESCAN):
5.63
Best Energy Score (PASTA 2.0):
-3.74
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2024 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-2024
Peptide:
SYGGEGIGNVAVAGELPVAGKTAVAGRVPIIGAVGFGGPAGAAGAVSIAGR
Length:
51
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
A0A0K2S2V2_BOMMO
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
54.9
NuAPRpred:
-9.59
Tango:
117.9
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.3
Area of the profile Above Threshold (AGGRESCAN):
9.8
Best Energy Score (PASTA 2.0):
-4.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2025 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
K
V
Y
G
R
C
E
L
A
A
A
M
K
R
L
G
L
D
N
Y
R
G
Y
S
L
G
N
W
V
C
A
A
K
F
E
S
N
F
N
T
H
A
T
N
R
N
T
D
G
S
T
D
Y
G
I
L
Q
I
N
S
60
61
R
W
W
C
N
D
G
R
T
P
G
S
R
N
L
C
N
I
P
C
S
A
L
L
S
S
D
I
T
A
S
V
N
C
A
K
K
I
V
S
D
R
N
G
M
N
A
W
V
A
W
R
N
R
C
K
G
T
D
V
120
121
H
A
W
I
R
G
C
R
L
129
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2025
Peptide:
GSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSD
Length:
53
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P19849
UniProt Name:
LYSC_PAVCR
Protein Name:
Lysozyme C
Position:
49-101
Literature
PMID:
15236974
Reference:
J Mol Biol. 2004 Jul 23;340(5):1153-65.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
9
Hydrophobicity:
43.4
NuAPRpred:
-1.85
Tango:
2.79
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.6
Area of the profile Above Threshold (AGGRESCAN):
7.94
Best Energy Score (PASTA 2.0):
-3.74
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2026 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
S
Y
W
L
L
A
L
F
V
A
M
W
T
D
V
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
T
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
N
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
M
M
H
F
G
N
D
W
E
D
R
Y
Y
R
E
N
M
N
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
N
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
I
K
I
M
E
R
V
V
E
Q
M
C
T
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
R
S
S
A
V
L
F
S
S
P
P
240
241
V
I
L
L
I
S
F
L
I
F
L
M
V
G
254
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2026
Peptide:
GQGGGTHNQWNKPSKPKTNMKHMAGAAAAGAVVGGLGYMLGSAMSRPMMHFGNDW
Length:
55
Classification:
Amyloid
Mutation(s):
[del]126G
Structure(s):
No structures
Protein Information
UniProt ID:
P04273
UniProt Name:
PRIO_MESAU
Protein Name:
Major prion protein (PrP)
Position:
90-145
Literature
PMID:
7563061
Reference:
J Mol Biol. 1995 Sep 29;252(4):412-22.
source:
CPAD
Derived Information
Net Charge:
4
Absolute Charge:
6
Hydrophobicity:
43.64
NuAPRpred:
-16.61
Tango:
39.14
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.9
Area of the profile Above Threshold (AGGRESCAN):
6.83
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2027 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-2027
Peptide:
GQGGGTHNQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPMMHFGNDW
Length:
56
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
PRIO_SHA
Protein Name:
Position:
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
4
Absolute Charge:
6
Hydrophobicity:
42.86
NuAPRpred:
-17.58
Tango:
15.38
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-19.5
Area of the profile Above Threshold (AGGRESCAN):
6.45
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2028 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2028
Peptide:
GQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYE
Length:
65
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
82-146
Literature
PMID:
16716083
Reference:
Biochemistry. 2006 May 30;45(21):6724-32.
source:
CPAD
Derived Information
Net Charge:
3
Absolute Charge:
7
Hydrophobicity:
40.0
NuAPRpred:
-20.58
Tango:
16.5
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.1
Area of the profile Above Threshold (AGGRESCAN):
8.02
Best Energy Score (PASTA 2.0):
-4.75
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2029 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-2029
Peptide:
MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPKK
Length:
71
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21575585
Reference:
Biophys J. 2011 May 18;100(10):2504-12.
source:
CPAD
Derived Information
Net Charge:
3
Absolute Charge:
7
Hydrophobicity:
26.76
NuAPRpred:
-14.79
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-76.8
Area of the profile Above Threshold (AGGRESCAN):
2.53
Best Energy Score (PASTA 2.0):
-1.12
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-2030 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2030
Peptide:
GKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQ
Length:
79
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
31-109
Literature
PMID:
11893734
Reference:
J Biol Chem. 2002 May 24;277(21):19213-9.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
18
Hydrophobicity:
37.97
NuAPRpred:
-7.51
Tango:
806.49
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.2
Area of the profile Above Threshold (AGGRESCAN):
10.77
Best Energy Score (PASTA 2.0):
-7.24
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2031 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
T
R
L
L
P
A
L
F
L
V
L
L
V
L
G
F
E
V
Q
G
T
Q
Q
P
Q
Q
D
E
M
P
S
P
T
F
L
T
Q
V
K
E
S
L
S
S
Y
W
E
S
A
K
T
A
A
Q
N
L
Y
E
60
61
K
T
Y
L
P
A
V
D
E
K
L
R
D
L
Y
S
K
S
T
A
A
M
S
T
Y
T
G
I
F
T
D
Q
V
L
S
V
L
K
G
E
E
101
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2031
Peptide:
DEPPQSPWDRVKDLATVYVDVLKDSRRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLR
Length:
83
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P02655
UniProt Name:
APOC2_HUMAN
Protein Name:
Apolipoprotein C-II (ApoC-II)
Position:
Literature
PMID:
3142462
Reference:
Biochem Biophys Res Commun. 1988 Oct 31;156(2):762-8.
source:
AmyLoad
Derived Information
Net Charge:
-5
Absolute Charge:
27
Hydrophobicity:
38.55
NuAPRpred:
-23.2
Tango:
349.11
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-21.7
Area of the profile Above Threshold (AGGRESCAN):
5.87
Best Energy Score (PASTA 2.0):
-6.05
Aggregate Orientation (PASTA 2.0):
Parallel