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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 151 to 180 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0151
ELNIYQ
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0152
ELPKVE
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0153
EMTVKQ
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0154
EPTKVE
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0155
EPTREP
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
K184R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0156
EPVKKE
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0157
EQIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623E
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0158
ERGFFY
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0159
ERIEKV
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0160
ESDKKE
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0161
ESNTNN
6
Non-amyloid
Glucose repression mediator protein CYC8
P14922
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0162
ETKEPT
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0163
ETVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0164
ETVIVI
6
Non-amyloid
Flocculation protein FLO1 (Flocculin-1)
P32768
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0165
ETWFFG
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0166
ETYVVT
6
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-0167
EVDLLK
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0168
EVTTGV
6
Non-amyloid
Caf1 hyphal wall protein 1
B2L5Z5
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0169
EYLKIA
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0170
EYSNFS
6
Amyloid
Acylphosphatase-2
P14621
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0171
FAIRHF
6
Amyloid
No
Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20.
15630094
Waltz-DB 2.0, AmyLoad
P-0172
FATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38F
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0173
FDTAST
6
Amyloid
Fibrinogen alpha chain
P02671
No
Blood. 1997 Dec 15;90(12):4799-805.
9389696
AmyLoad
P-0174
FERQHM
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
20133726
Waltz-DB 2.0, AmyLoad
P-0175
FESNFN
6
Amyloid
Lysozyme C
P00698
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0176
FFNLNN
6
Non-amyloid
SWI/SNF chromatin-remodeling complex subunit SWI1
P09547
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0177
FFWRFM
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0178
FFYTPK
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0179
FGAFSI
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0180
FGELFE
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
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Entry: P-0151 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0151
Peptide:
ELNIYQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
44-49
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.2
Area of the profile Above Threshold (AGGRESCAN):
0.74
Best Energy Score (PASTA 2.0):
-3.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0152 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0152
Peptide:
ELPKVE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
211-216
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-31.9
Area of the profile Above Threshold (AGGRESCAN):
0.08
Best Energy Score (PASTA 2.0):
1.95
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0153 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0153
Peptide:
EMTVKQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
112-117
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.34
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-16.1
Area of the profile Above Threshold (AGGRESCAN):
0.08
Best Energy Score (PASTA 2.0):
-2.38
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0154 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0154
Peptide:
EPTKVE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
185-190
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
33.33
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-51.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.3
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0155 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0155
Peptide:
EPTREP
Length:
6
Classification:
Non-amyloid
Mutation(s):
K184R
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
181-186
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
33.33
NuAPRpred:
-0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-86.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0156 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0156
Peptide:
EPVKKE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
191-196
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
33.33
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-49.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.24
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0157 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0157
Peptide:
EQIVYK
Length:
6
Classification:
amyloid
Mutation(s):
V623E
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
25.9
Area of the profile Above Threshold (AGGRESCAN):
1.97
Best Energy Score (PASTA 2.0):
-3.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0158 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0158
Peptide:
ERGFFY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
45-50
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.6
Area of the profile Above Threshold (AGGRESCAN):
1.94
Best Energy Score (PASTA 2.0):
-1.58
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0159 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0159
Peptide:
ERIEKV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
64-69
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
33.33
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-37.0
Area of the profile Above Threshold (AGGRESCAN):
0.04
Best Energy Score (PASTA 2.0):
-2.59
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0160 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0160
Peptide:
ESDKKE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
167-172
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
0.0
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-118.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.28
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0161 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
P
G
G
E
Q
T
I
M
E
Q
P
A
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
A
A
V
P
Q
Q
P
L
D
P
L
T
Q
S
T
A
E
T
W
L
S
I
A
S
L
A
E
T
L
G
60
61
D
G
D
R
A
A
M
A
Y
D
A
T
L
Q
F
N
P
S
S
A
K
A
L
T
S
L
A
H
L
Y
R
S
R
D
M
F
Q
R
A
A
E
L
Y
E
R
A
L
L
V
N
P
E
L
S
D
V
W
A
T
L
120
121
G
H
C
Y
L
M
L
D
D
L
Q
R
A
Y
N
A
Y
Q
Q
A
L
Y
H
L
S
N
P
N
V
P
K
L
W
H
G
I
G
I
L
Y
D
R
Y
G
S
L
D
Y
A
E
E
A
F
A
K
V
L
E
L
D
180
181
P
H
F
E
K
A
N
E
I
Y
F
R
L
G
I
I
Y
K
H
Q
G
K
W
S
Q
A
L
E
C
F
R
Y
I
L
P
Q
P
P
A
P
L
Q
E
W
D
I
W
F
Q
L
G
S
V
L
E
S
M
G
E
W
240
241
Q
G
A
K
E
A
Y
E
H
V
L
A
Q
N
Q
H
H
A
K
V
L
Q
Q
L
G
C
L
Y
G
M
S
N
V
Q
F
Y
D
P
Q
K
A
L
D
Y
L
L
K
S
L
E
A
D
P
S
D
A
T
T
W
Y
300
301
H
L
G
R
V
H
M
I
R
T
D
Y
T
A
A
Y
D
A
F
Q
Q
A
V
N
R
D
S
R
N
P
I
F
W
C
S
I
G
V
L
Y
Y
Q
I
S
Q
Y
R
D
A
L
D
A
Y
T
R
A
I
R
L
N
360
361
P
Y
I
S
E
V
W
Y
D
L
G
T
L
Y
E
T
C
N
N
Q
L
S
D
A
L
D
A
Y
K
Q
A
A
R
L
D
V
N
N
V
H
I
R
E
R
L
E
A
L
T
K
Q
L
E
N
P
G
N
I
N
K
420
421
S
N
G
A
P
T
N
A
S
P
A
P
P
P
V
I
L
Q
P
T
L
Q
P
N
D
Q
G
N
P
L
N
T
R
I
S
A
Q
S
A
N
A
T
A
S
M
V
Q
Q
Q
H
P
A
Q
Q
T
P
I
N
S
S
480
481
A
T
M
Y
S
N
G
A
S
P
Q
L
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
H
A
Q
A
540
541
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
L
Q
P
L
P
R
Q
Q
L
Q
Q
K
G
600
601
V
S
V
Q
M
L
N
P
Q
Q
G
Q
P
Y
I
T
Q
P
T
V
I
Q
A
H
Q
L
Q
P
F
S
T
Q
A
M
E
H
P
Q
S
S
Q
L
P
P
Q
Q
Q
Q
L
Q
S
V
Q
H
P
Q
Q
L
Q
G
660
661
Q
P
Q
A
Q
A
P
Q
P
L
I
Q
H
N
V
E
Q
N
V
L
P
Q
K
R
Y
M
E
G
A
I
H
T
L
V
D
A
A
V
S
S
S
T
H
T
E
N
N
T
K
S
P
R
Q
P
T
H
A
I
P
T
720
721
Q
A
P
A
T
G
I
T
N
A
E
P
Q
V
K
K
Q
K
L
N
S
P
N
S
N
I
N
K
L
V
N
T
A
T
S
I
E
E
N
A
K
S
E
V
S
N
Q
S
P
A
V
V
E
S
N
T
N
N
T
S
780
781
Q
E
E
K
P
V
K
A
N
S
I
P
S
V
I
G
A
Q
E
P
P
Q
E
A
S
P
A
E
E
A
T
K
A
A
S
V
S
P
S
T
K
P
L
N
T
E
P
E
S
S
S
V
Q
P
T
V
S
S
E
S
840
841
S
T
T
K
A
N
D
Q
S
T
A
E
T
I
E
L
S
T
A
T
V
P
A
E
A
S
P
V
E
D
E
V
R
Q
H
S
K
E
E
N
G
T
T
E
A
S
A
P
S
T
E
E
A
E
P
A
A
S
R
D
900
901
A
E
K
Q
Q
D
E
T
A
A
T
T
I
T
V
I
K
P
T
L
E
T
M
E
T
V
K
E
E
A
K
M
R
E
E
E
Q
T
S
Q
E
K
S
P
Q
E
N
T
L
P
R
E
N
V
V
R
Q
V
E
E
960
961
D
E
N
Y
D
D
966
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0161
Peptide:
ESNTNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14922
UniProt Name:
CYC8_YEAST
Protein Name:
Glucose repression mediator protein CYC8
Position:
773-778
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-95.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.01
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0162 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0162
Peptide:
ETKEPT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
178-183
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.64
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-87.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.76
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0163 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0163
Peptide:
ETVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.73
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
44.2
Area of the profile Above Threshold (AGGRESCAN):
2.8
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0164 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
M
P
H
R
Y
M
F
L
A
V
F
T
L
L
A
L
T
S
V
A
S
G
A
T
E
A
C
L
P
A
G
Q
R
K
S
G
M
N
I
N
F
Y
Q
Y
S
L
K
D
S
S
T
Y
S
N
A
A
Y
M
60
61
A
Y
G
Y
A
S
K
T
K
L
G
S
V
G
G
Q
T
D
I
S
I
D
Y
N
I
P
C
V
S
S
S
G
T
F
P
C
P
Q
E
D
S
Y
G
N
W
G
C
K
G
M
G
A
C
S
N
S
Q
G
I
A
120
121
Y
W
S
T
D
L
F
G
F
Y
T
T
P
T
N
V
T
L
E
M
T
G
Y
F
L
P
P
Q
T
G
S
Y
T
F
K
F
A
T
V
D
D
S
A
I
L
S
V
G
G
A
T
A
F
N
C
C
A
Q
Q
Q
180
181
P
P
I
T
S
T
N
F
T
I
D
G
I
K
P
W
G
G
S
L
P
P
N
I
E
G
T
V
Y
M
Y
A
G
Y
Y
Y
P
M
K
V
V
Y
S
N
A
V
S
W
G
T
L
P
I
S
V
T
L
P
D
G
240
241
T
T
V
S
D
D
F
E
G
Y
V
Y
S
F
D
D
D
L
S
Q
S
N
C
T
V
P
D
P
S
N
Y
A
V
S
T
T
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
300
301
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
T
A
S
T
I
I
T
T
T
E
P
W
N
S
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
V
R
T
D
E
T
I
I
V
I
R
T
P
360
361
T
T
A
T
T
A
I
T
T
T
E
P
W
N
S
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
420
421
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
480
481
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
I
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
540
541
T
T
A
T
T
A
M
T
T
P
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
I
T
T
T
E
P
W
N
S
600
601
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
I
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
660
661
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
I
T
T
V
T
G
T
T
G
L
P
T
D
E
T
I
I
V
I
R
T
P
720
721
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
780
781
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
V
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
I
T
G
T
840
841
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
I
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
900
901
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
H
V
T
G
T
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
960
961
T
F
T
S
T
S
T
E
V
T
T
I
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
1020
1021
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
V
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
S
T
V
T
G
T
N
G
L
P
T
D
E
T
V
I
V
V
K
T
P
1080
1081
T
T
A
I
S
S
S
L
S
S
S
S
S
G
Q
I
T
S
S
I
T
S
S
R
P
I
I
T
P
F
Y
P
S
N
G
T
S
V
I
S
S
S
V
I
S
S
S
V
T
S
S
L
F
T
S
S
P
V
I
S
1140
1141
S
S
V
I
S
S
S
T
T
T
S
T
S
I
F
S
E
S
S
K
S
S
V
I
P
T
S
S
S
T
S
G
S
S
E
S
E
T
S
S
A
G
S
V
S
S
S
S
F
I
S
S
E
S
S
K
S
P
T
Y
1200
1201
S
S
S
S
L
P
L
V
T
S
A
T
T
S
Q
E
T
A
S
S
L
P
P
A
T
T
T
K
T
S
E
Q
T
T
L
V
T
V
T
S
C
E
S
H
V
C
T
E
S
I
S
P
A
I
V
S
T
A
T
V
1260
1261
T
V
S
G
V
T
T
E
Y
T
T
W
C
P
I
S
T
T
E
T
T
K
Q
T
K
G
T
T
E
Q
T
T
E
T
T
K
Q
T
T
V
V
T
I
S
S
C
E
S
D
V
C
S
K
T
A
S
P
A
I
V
1320
1321
S
T
S
T
A
T
I
N
G
V
T
T
E
Y
T
T
W
C
P
I
S
T
T
E
S
R
Q
Q
T
T
L
V
T
V
T
S
C
E
S
G
V
C
S
E
T
A
S
P
A
I
V
S
T
A
T
A
T
V
N
D
1380
1381
V
V
T
V
Y
P
T
W
R
P
Q
T
A
N
E
E
S
V
S
S
K
M
N
S
A
T
G
E
T
T
T
N
T
L
A
A
E
T
T
T
N
T
V
A
A
E
T
I
T
N
T
G
A
A
E
T
K
T
V
V
1440
1441
T
S
S
L
S
R
S
N
H
A
E
T
Q
T
A
S
A
T
D
V
I
G
H
S
S
S
V
V
S
V
S
E
T
G
N
T
K
S
L
T
S
S
G
L
S
T
M
S
Q
Q
P
R
S
T
P
A
S
S
M
V
1500
1501
G
Y
S
T
A
S
L
E
I
S
T
Y
A
G
S
A
N
S
L
L
A
G
S
G
L
S
V
F
I
A
S
L
L
L
A
I
I
1537
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0164
Peptide:
ETVIVI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32768
UniProt Name:
FLO1_YEAST
Protein Name:
Flocculation protein FLO1 (Flocculin-1)
Position:
307-312
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
1.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
73.5
Area of the profile Above Threshold (AGGRESCAN):
4.56
Best Energy Score (PASTA 2.0):
-8.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0165 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0165
Peptide:
ETWFFG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.31
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
39.6
Area of the profile Above Threshold (AGGRESCAN):
2.62
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0166 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0166
Peptide:
ETYVVT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
68-73
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.4
Area of the profile Above Threshold (AGGRESCAN):
2.68
Best Energy Score (PASTA 2.0):
-4.6
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0167 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0167
Peptide:
EVDLLK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
56-61
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
0.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.0
Area of the profile Above Threshold (AGGRESCAN):
0.58
Best Energy Score (PASTA 2.0):
-2.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0168 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
L
S
T
A
Q
L
I
A
I
A
Y
Y
M
L
S
I
G
A
T
V
P
Q
V
D
G
Q
G
E
T
E
E
A
L
I
Q
K
R
S
Y
D
Y
Y
Q
E
P
C
D
D
Y
P
Q
Q
Q
Q
Q
E
E
P
60
61
C
D
Y
P
Q
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
120
121
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
Q
P
D
D
N
P
P
I
P
N
I
P
T
D
W
I
P
N
I
P
T
D
W
I
P
D
I
P
E
K
P
180
181
T
T
P
A
T
T
P
N
I
P
A
T
T
T
T
S
E
S
S
S
S
S
S
S
S
S
S
T
T
P
K
T
S
A
S
T
T
P
E
S
S
V
P
A
T
T
P
N
T
S
V
P
T
T
S
S
E
S
T
T
240
241
P
A
T
S
P
E
S
S
V
P
V
T
S
G
S
S
I
L
A
T
T
S
E
S
S
S
A
P
A
T
T
P
N
T
S
V
P
T
T
T
T
E
T
K
S
S
S
T
P
L
T
T
T
T
E
H
D
T
T
V
300
301
V
T
V
T
S
C
S
N
S
V
C
T
E
S
E
V
T
T
G
V
I
V
I
T
S
K
D
T
I
Y
T
T
Y
C
P
L
T
E
T
T
P
V
S
T
A
P
A
T
E
T
P
T
G
T
V
S
T
S
T
E
360
361
Q
S
T
T
V
I
T
V
T
S
C
S
E
S
S
C
T
E
S
E
V
T
T
G
V
V
V
V
T
S
E
E
T
V
Y
T
T
F
C
P
L
T
E
N
T
P
G
T
D
S
T
P
E
A
S
I
P
P
M
E
420
421
T
I
P
A
G
S
E
P
S
M
P
A
G
E
T
S
P
A
V
P
K
S
D
V
P
A
T
E
S
A
P
A
P
G
M
T
P
A
G
T
E
T
K
P
A
A
P
K
S
S
A
P
A
T
E
P
S
P
V
A
480
481
P
G
T
E
S
A
P
A
G
S
S
G
A
I
T
I
P
E
S
S
A
V
V
S
T
T
E
G
A
I
P
T
T
L
E
S
V
P
L
M
Q
P
S
A
N
Y
S
S
V
A
P
I
S
T
F
E
G
A
G
N
540
541
N
M
R
L
T
F
G
A
A
I
I
G
I
A
A
F
L
I
558
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0168
Peptide:
EVTTGV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B2L5Z5
UniProt Name:
B2L5Z5_9ASCO
Protein Name:
Caf1 hyphal wall protein 1
Position:
315-320
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-8.5
Area of the profile Above Threshold (AGGRESCAN):
0.49
Best Energy Score (PASTA 2.0):
-2.83
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0169 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0169
Peptide:
EYLKIA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
0.12
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
16.2
Area of the profile Above Threshold (AGGRESCAN):
1.62
Best Energy Score (PASTA 2.0):
-1.82
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0170 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
T
A
Q
S
L
K
S
V
D
Y
E
V
F
G
R
V
Q
G
V
C
F
R
M
Y
T
E
D
E
A
R
K
I
G
V
V
G
W
V
K
N
T
S
K
G
T
V
T
G
Q
V
Q
G
P
E
D
K
V
N
60
61
S
M
K
S
W
L
S
K
V
G
S
P
S
S
R
I
D
R
T
N
F
S
N
E
K
T
I
S
K
L
E
Y
S
N
F
S
I
R
Y
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0170
Peptide:
EYSNFS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14621
UniProt Name:
ACYP2_HUMAN
Protein Name:
Acylphosphatase-2
Position:
91-96
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.07
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-28.2
Area of the profile Above Threshold (AGGRESCAN):
0.23
Best Energy Score (PASTA 2.0):
-0.95
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0171 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0171
Peptide:
FAIRHF
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
15630094
Reference:
Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.4
Area of the profile Above Threshold (AGGRESCAN):
1.06
Best Energy Score (PASTA 2.0):
-1.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0172 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0172
Peptide:
FATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38F
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.76
Tango:
3.74
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
59.1
Area of the profile Above Threshold (AGGRESCAN):
3.83
Best Energy Score (PASTA 2.0):
-4.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0173 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
F
S
M
R
I
V
C
L
V
L
S
V
V
G
T
A
W
T
A
D
S
G
E
G
D
F
L
A
E
G
G
G
V
R
G
P
R
V
V
E
R
H
Q
S
A
C
K
D
S
D
W
P
F
C
S
D
E
D
W
60
61
N
Y
K
C
P
S
G
C
R
M
K
G
L
I
D
E
V
N
Q
D
F
T
N
R
I
N
K
L
K
N
S
L
F
E
Y
Q
K
N
N
K
D
S
H
S
L
T
T
N
I
M
E
I
L
R
G
D
F
S
S
A
120
121
N
N
R
D
N
T
Y
N
R
V
S
E
D
L
R
S
R
I
E
V
L
K
R
K
V
I
E
K
V
Q
H
I
Q
L
L
Q
K
N
V
R
A
Q
L
V
D
M
K
R
L
E
V
D
I
D
I
K
I
R
S
C
180
181
R
G
S
C
S
R
A
L
A
R
E
V
D
L
K
D
Y
E
D
Q
Q
K
Q
L
E
Q
V
I
A
K
D
L
L
P
S
R
D
R
Q
H
L
P
L
I
K
M
K
P
V
P
D
L
V
P
G
N
F
K
S
Q
240
241
L
Q
K
V
P
P
E
W
K
A
L
T
D
M
P
Q
M
R
M
E
L
E
R
P
G
G
N
E
I
T
R
G
G
S
T
S
Y
G
T
G
S
E
T
E
S
P
R
N
P
S
S
A
G
S
W
N
S
G
S
S
300
301
G
P
G
S
T
G
N
R
N
P
G
S
S
G
T
G
G
T
A
T
W
K
P
G
S
S
G
P
G
S
T
G
S
W
N
S
G
S
S
G
T
G
S
T
G
N
Q
N
P
G
S
P
R
P
G
S
T
G
T
W
360
361
N
P
G
S
S
E
R
G
S
A
G
H
W
T
S
E
S
S
V
S
G
S
T
G
Q
W
H
S
E
S
G
S
F
R
P
D
S
P
G
S
G
N
A
R
P
N
N
P
D
W
G
T
F
E
E
V
S
G
N
V
420
421
S
P
G
T
R
R
E
Y
H
T
E
K
L
V
T
S
K
G
D
K
E
L
R
T
G
K
E
K
V
T
S
G
S
T
T
T
T
R
R
S
C
S
K
T
V
T
K
T
V
I
G
P
D
G
H
K
E
V
T
K
480
481
E
V
V
T
S
E
D
G
S
D
C
P
E
A
M
D
L
G
T
L
S
G
I
G
T
L
D
G
F
R
H
R
H
P
D
E
A
A
F
F
D
T
A
S
T
G
K
T
F
P
G
F
F
S
P
M
L
G
E
F
540
541
V
S
E
T
E
S
R
G
S
E
S
G
I
F
T
N
T
K
E
S
S
S
H
H
P
G
I
A
E
F
P
S
R
G
K
S
S
S
Y
S
K
Q
F
T
S
S
T
S
Y
N
R
G
D
S
T
F
E
S
K
S
600
601
Y
K
M
A
D
E
A
G
S
E
A
D
H
E
G
T
H
S
T
K
R
G
H
A
K
S
R
P
V
R
D
C
D
D
V
L
Q
T
H
P
S
G
T
Q
S
G
I
F
N
I
K
L
P
G
S
S
K
I
F
S
660
661
V
Y
C
D
Q
E
T
S
L
G
G
W
L
L
I
Q
Q
R
M
D
G
S
L
N
F
N
R
T
W
Q
D
Y
K
R
G
F
G
S
L
N
D
E
G
E
G
E
F
W
L
G
N
D
Y
L
H
L
L
T
Q
R
720
721
G
S
V
L
R
V
E
L
E
D
W
A
G
N
E
A
Y
A
E
Y
H
F
R
V
G
S
E
A
E
G
Y
A
L
Q
V
S
S
Y
E
G
T
A
G
D
A
L
I
E
G
S
V
E
E
G
A
E
Y
T
S
H
780
781
N
N
M
Q
F
S
T
F
D
R
D
A
D
Q
W
E
E
N
C
A
E
V
Y
G
G
G
W
W
Y
N
N
C
Q
A
A
N
L
N
G
I
Y
Y
P
G
G
S
Y
D
P
R
N
N
S
P
Y
E
I
E
N
G
840
841
V
V
W
V
S
F
R
G
A
D
Y
S
L
R
A
V
R
M
K
I
R
P
L
V
T
Q
866
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0173
Peptide:
FDTAST
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02671
UniProt Name:
FIBA_HUMAN
Protein Name:
Fibrinogen alpha chain
Position:
520-525
Literature
PMID:
9389696
Reference:
Blood. 1997 Dec 15;90(12):4799-805.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-34.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.02
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0174 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0174
Peptide:
FERQHM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20133726
Reference:
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-73.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.44
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0175 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
S
L
L
I
L
V
L
C
F
L
P
L
A
A
L
G
K
V
F
G
R
C
E
L
A
A
A
M
K
R
H
G
L
D
N
Y
R
G
Y
S
L
G
N
W
V
C
A
A
K
F
E
S
N
F
N
T
Q
A
60
61
T
N
R
N
T
D
G
S
T
D
Y
G
I
L
Q
I
N
S
R
W
W
C
N
D
G
R
T
P
G
S
R
N
L
C
N
I
P
C
S
A
L
L
S
S
D
I
T
A
S
V
N
C
A
K
K
I
V
S
D
G
120
121
N
G
M
N
A
W
V
A
W
R
N
R
C
K
G
T
D
V
Q
A
W
I
R
G
C
R
L
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0175
Peptide:
FESNFN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00698
UniProt Name:
LYSC_CHICK
Protein Name:
Lysozyme C
Position:
52-57
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
0.14
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-40.9
Area of the profile Above Threshold (AGGRESCAN):
0.12
Best Energy Score (PASTA 2.0):
-0.18
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0176 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
F
F
N
L
N
N
N
N
N
N
N
N
T
T
T
T
T
T
T
T
N
N
N
N
T
N
N
N
N
T
N
N
N
N
N
P
A
N
N
T
N
N
N
N
S
T
G
H
S
S
N
T
N
N
N
T
N
N
60
61
N
N
T
N
T
G
A
S
G
V
D
D
F
Q
N
F
F
D
P
K
P
F
D
Q
N
L
D
S
N
N
N
N
S
N
S
N
N
N
D
N
N
N
S
N
T
V
A
S
S
T
N
F
T
S
P
T
A
V
V
N
120
121
N
A
A
P
A
N
V
T
G
G
K
A
A
N
F
I
Q
N
Q
S
P
Q
F
N
S
P
Y
D
S
N
N
S
N
T
N
L
N
S
L
S
P
Q
A
I
L
A
K
N
S
I
I
D
S
S
N
L
P
L
Q
A
180
181
Q
Q
Q
L
Y
G
G
N
N
N
N
N
S
T
G
I
A
N
D
N
V
I
T
P
H
F
I
T
N
V
Q
S
I
S
Q
N
S
S
S
S
T
P
N
T
N
S
N
S
T
P
N
A
N
Q
Q
F
L
P
F
N
240
241
N
S
A
S
N
N
G
N
L
T
S
N
Q
L
I
S
N
Y
A
A
S
N
S
M
D
R
S
S
S
A
S
N
E
F
V
P
N
T
S
D
N
N
N
N
S
N
N
H
N
M
R
N
N
S
N
N
K
T
S
N
300
301
N
N
N
V
T
A
V
P
A
A
T
P
A
N
T
N
N
S
T
S
N
A
N
T
V
F
S
E
R
A
A
M
F
A
A
L
Q
Q
K
Q
Q
Q
R
F
Q
A
L
Q
Q
Q
Q
Q
Q
Q
Q
N
Q
Q
Q
Q
360
361
N
Q
Q
P
Q
Q
Q
Q
Q
Q
Q
Q
N
P
K
F
L
Q
S
Q
R
Q
Q
Q
Q
R
S
I
L
Q
S
L
N
P
A
L
Q
E
K
I
S
T
E
L
N
N
K
Q
Y
E
L
F
M
K
S
L
I
E
N
C
420
421
K
K
R
N
M
P
L
Q
S
I
P
E
I
G
N
R
K
I
N
L
F
Y
L
Y
M
L
V
Q
K
F
G
G
A
D
Q
V
T
R
T
Q
Q
W
S
M
V
A
Q
R
L
Q
I
S
D
Y
Q
Q
L
E
S
I
480
481
Y
F
R
I
L
L
P
Y
E
R
H
M
I
S
Q
E
G
I
K
E
T
Q
A
K
R
I
F
L
Q
Q
F
L
Q
E
L
L
K
K
V
Q
Q
Q
Q
Q
A
A
A
L
A
N
A
N
N
N
I
N
S
A
S
S
540
541
A
P
T
P
A
A
P
G
A
S
V
P
A
T
A
A
P
G
T
E
A
G
I
V
P
V
S
A
N
T
P
K
S
L
N
S
N
I
N
I
N
V
N
N
N
N
I
G
Q
Q
Q
V
K
K
P
R
K
Q
R
V
600
601
K
K
K
T
K
K
E
L
E
L
E
R
K
E
R
E
D
F
Q
K
R
Q
Q
K
L
L
E
D
Q
Q
R
Q
Q
K
L
L
L
E
T
K
L
R
Q
Q
Y
E
I
E
L
K
K
L
P
K
V
Y
K
R
S
I
660
661
V
R
N
Y
K
P
L
I
N
R
L
K
H
Y
N
G
Y
D
I
N
Y
I
S
K
I
G
E
K
I
D
S
N
K
P
I
F
L
F
A
P
E
L
G
A
I
N
L
H
A
L
S
M
S
L
Q
S
K
N
L
G
720
721
E
I
N
T
A
L
N
T
L
L
V
T
S
A
D
S
N
L
K
I
S
L
V
K
Y
P
E
L
L
D
S
L
A
I
L
G
M
N
L
L
S
N
L
S
Q
N
V
V
P
Y
H
R
N
T
S
D
Y
Y
Y
E
780
781
D
A
G
S
N
Q
Y
Y
V
T
Q
H
D
K
M
V
D
K
I
F
E
K
V
N
N
N
A
T
L
T
P
N
D
S
N
D
E
K
V
T
I
L
V
D
S
L
T
G
N
Q
L
P
T
P
T
P
T
E
M
E
840
841
P
D
L
D
T
E
C
F
I
S
M
Q
S
T
S
P
A
V
K
Q
W
D
L
L
P
E
P
I
R
F
L
P
N
Q
F
P
L
K
I
H
R
T
P
Y
L
T
S
L
K
K
I
K
D
E
I
D
D
P
F
T
900
901
K
I
N
T
R
G
A
E
D
P
K
V
L
I
N
D
Q
L
S
T
I
S
M
I
L
R
N
I
S
F
S
D
N
N
S
R
I
M
S
R
N
F
Y
L
K
R
F
I
S
D
L
L
W
L
V
L
I
H
P
E
960
961
N
F
T
C
N
R
K
I
L
N
F
K
K
D
L
V
I
V
L
S
N
I
S
H
L
L
E
I
A
S
S
I
D
C
L
L
I
L
I
L
V
I
S
F
G
Q
P
K
L
N
P
M
A
S
S
S
S
F
G
S
1020
1021
E
S
L
T
F
N
E
F
Q
L
Q
W
G
K
Y
Q
T
F
G
V
D
I
L
A
K
L
F
S
L
E
K
P
N
L
N
Y
F
K
S
I
L
L
N
K
N
T
G
N
N
L
Y
D
R
N
S
N
N
N
H
K
1080
1081
D
K
K
L
L
R
R
L
L
N
L
Y
N
D
N
N
K
N
N
N
N
R
H
N
L
L
N
D
V
V
S
F
L
F
S
A
I
P
L
Q
Q
V
L
S
Q
S
A
D
P
S
L
L
I
D
Q
F
S
P
V
I
1140
1141
S
Q
S
L
T
S
I
L
V
I
V
Q
K
I
L
P
L
S
N
E
V
F
E
I
S
E
N
N
S
D
S
N
S
N
N
N
G
N
K
D
S
S
F
N
F
N
K
N
L
P
F
V
W
L
S
S
E
E
N
I
1200
1201
G
S
G
L
L
K
L
S
E
I
I
L
N
I
N
N
S
T
S
K
N
T
L
L
Q
Q
Q
N
Y
S
K
V
L
L
P
S
I
N
I
S
C
V
Q
L
I
K
C
L
V
E
K
S
I
C
F
E
N
C
L
N
1260
1261
N
D
P
E
I
L
K
K
I
A
S
I
P
N
L
F
P
T
D
L
E
I
F
Q
L
F
T
N
P
S
V
D
I
Q
I
I
N
Q
Y
Q
L
L
Y
N
L
K
N
D
I
L
T
N
L
E
1314
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0176
Peptide:
FFNLNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09547
UniProt Name:
SWI1_YEAST
Protein Name:
SWI/SNF chromatin-remodeling complex subunit SWI1
Position:
3-8
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.0
Area of the profile Above Threshold (AGGRESCAN):
1.51
Best Energy Score (PASTA 2.0):
-2.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0177 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0177
Peptide:
FFWRFM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
-0.09
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
51.3
Area of the profile Above Threshold (AGGRESCAN):
3.38
Best Energy Score (PASTA 2.0):
-3.82
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0178 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0178
Peptide:
FFYTPK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
48-53
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
29.1
Area of the profile Above Threshold (AGGRESCAN):
2.66
Best Energy Score (PASTA 2.0):
-2.29
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0179 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0179
Peptide:
FGAFSI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
313-318
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
41.0
Area of the profile Above Threshold (AGGRESCAN):
2.72
Best Energy Score (PASTA 2.0):
-1.7
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0180 Classification: Non-amyloid
CSV
JSON
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Peptide details
Entry:
P-0180
Peptide:
FGELFE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.0
Area of the profile Above Threshold (AGGRESCAN):
0.61
Best Energy Score (PASTA 2.0):
0.22
Aggregate Orientation (PASTA 2.0):
Antiparallel
