Home
Links
APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Tutorial
Statistics
Download
Contact Us
Home
Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
help
Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
Enter the query text:
help
Select a class:
help
All
Amyloid
Non-Amyloid
Submit
Reset
Max. of 30 records would be displayed in a single page.
Patterns can be used in the search.
«
1
2
62
63
64
65
66
67
(current)
68
»
Displaying 1981 to 2010 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1981
DAEFRHDSGYEVHHLKLVFFAEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
Q686L
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1982
DAEFRHDSGYEVHHQKLVFFAADVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
E693A
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1983
DAEFRHDSGYEVHHQKLVFFADDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
E693D
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1984
DAEFRHDSGYEVHHQKLVFFAEDMGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
V695M
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1985
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLLVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
M706L
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1986
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMPGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
V707P
J Mol Biol. 2004 Jan 16;335(3):833-42.
14687578
CPAD
P-1987
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1988
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGPVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
G708P
J Mol Biol. 2004 Jan 16;335(3):833-42.
14687578
CPAD
P-1989
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVPGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
G708P
J Mol Biol. 2004 Jan 16;335(3):833-42.
14687578
CPAD
P-1990
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIVLMVGGVA
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
G704V, V711A
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1991
DAEFRHDSGYEVHHQKLVFFAEDVGSSKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
N698S
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1992
DAEFRHDSGYEVHHQKLVFFAEYVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
D694Y
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1993
DAEFRHDSGYEVHHQKLVFFAPDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
E693P
J Mol Biol. 2004 Jan 16;335(3):833-42.
14687578
CPAD
P-1994
DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
E693Q
FEBS Lett. 1995 Sep 4;371(2):110-4.
7672107
CPAD
P-1995
DAEFRHDSGYEVHHQKLVFFMEDVGSNKGAIIGLLVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
A692M, M706L
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1996
DAEFRHDSGYEVHHQKLVVFVEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
F690V, A692V
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1997
DAEFRHDSGYEVHHQKPVFFAEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
L688P
J Mol Biol. 2004 Jan 16;335(3):833-42.
14687578
CPAD
P-1998
DAEFRHDSGYEVHHQTLVFFAEDAGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
K687T, V695A
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-1999
DAEFRHDSGYEVHHQTLVFFVEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
K687T, A692V
J Mol Biol. 2004 Jan 16;335(3):833-42.
14687578
CPAD
P-2000
DAEFRHDSGYEVHHRKLVFFAEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
Q686R
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-2001
DAEFRHDSGYEVHPQKLVFFAEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
H685P
J Mol Biol. 2004 Jan 16;335(3):833-42.
14687578
CPAD
P-2002
DAEFRHDSGYEVHYQKLVFFAEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
H685Y
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-2003
DAEFRHNSGYEVHYQKLVFFAEDVGSNKGAIIGLMVGGVM
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
D678N, H685Y, V711M
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-2004
DAEPRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
F675P
J Mol Biol. 2004 Jan 16;335(3):833-42.
14687578
CPAD
P-2005
DVEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
A673V
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-2006
DVEFRHDSGYEVHHQKLVFFAEDVGSNKGALIGLLVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
A673V, I702L, M706L
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-2007
DVEFRHDSGYEVHHQKLVFFAGDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
A673V, E693G
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-2008
GAEFRHDSGYEVHHQKLVFFVEDVGSNKGAIIGLMVGGVV
40
Amyloid
Amyloid-beta precursor protein (APP)
P05067
D672G, A692V
J Mol Biol. 2008 Mar 21;377(2):565-74.
18258258
CPAD
P-2009
DAEFRHDSGYEVHHQKLVAFFEDVGSNKGAIIGLLGGVVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
F690A, A692F, M706L, V707G, G709V
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
16293696
CPAD
P-2010
DAEFRHDSGYEVHHQKLVAFFEDVGSNKGAIIGLLVGGVVIA
42
Amyloid
Amyloid-beta precursor protein (APP)
P05067
F690A, A692F, M706L
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
16293696
CPAD
«
1
2
62
63
64
65
66
67
(current)
68
»
<
Entry: P-1981 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1981
Peptide:
DAEFRHDSGYEVHHLKLVFFAEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
Q686L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.5
NuAPRpred:
1.36
Tango:
877.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.2
Area of the profile Above Threshold (AGGRESCAN):
12.03
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1982 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1982
Peptide:
DAEFRHDSGYEVHHQKLVFFAADVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
E693A
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
47.5
NuAPRpred:
0.45
Tango:
969.05
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.1
Area of the profile Above Threshold (AGGRESCAN):
11.82
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1983 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1983
Peptide:
DAEFRHDSGYEVHHQKLVFFADDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
E693D
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
-0.7
Tango:
875.43
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.4
Area of the profile Above Threshold (AGGRESCAN):
10.81
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1984 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1984
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDMGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
V695M
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
-0.92
Tango:
875.77
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.1
Area of the profile Above Threshold (AGGRESCAN):
10.96
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1985 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1985
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLLVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
1.62
Tango:
1070.12
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.8
Area of the profile Above Threshold (AGGRESCAN):
11.46
Best Energy Score (PASTA 2.0):
-7.47
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1986 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1986
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMPGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
V707P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
14687578
Reference:
J Mol Biol. 2004 Jan 16;335(3):833-42.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
-5.22
Tango:
441.24
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.2
Area of the profile Above Threshold (AGGRESCAN):
8.87
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1987 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1987
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
-0.05
Tango:
875.77
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.3
Area of the profile Above Threshold (AGGRESCAN):
10.99
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1988 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1988
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGPVV
Length:
40
Classification:
Amyloid
Mutation(s):
G708P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
14687578
Reference:
J Mol Biol. 2004 Jan 16;335(3):833-42.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.5
NuAPRpred:
-2.45
Tango:
752.21
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.2
Area of the profile Above Threshold (AGGRESCAN):
10.39
Best Energy Score (PASTA 2.0):
-5.55
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1989 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1989
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVPGVV
Length:
40
Classification:
Amyloid
Mutation(s):
G708P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
14687578
Reference:
J Mol Biol. 2004 Jan 16;335(3):833-42.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.5
NuAPRpred:
-3.48
Tango:
483.56
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.3
Area of the profile Above Threshold (AGGRESCAN):
10.57
Best Energy Score (PASTA 2.0):
-5.55
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1990 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1990
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIVLMVGGVA
Length:
40
Classification:
Amyloid
Mutation(s):
G704V, V711A
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.5
NuAPRpred:
1.28
Tango:
1151.39
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.5
Area of the profile Above Threshold (AGGRESCAN):
12.34
Best Energy Score (PASTA 2.0):
-8.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1991 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1991
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSSKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
N698S
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
-0.12
Tango:
876.06
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.2
Area of the profile Above Threshold (AGGRESCAN):
11.02
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1992 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1992
Peptide:
DAEFRHDSGYEVHHQKLVFFAEYVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
D694Y
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
47.5
NuAPRpred:
3.09
Tango:
925.6
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.1
Area of the profile Above Threshold (AGGRESCAN):
12.63
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1993 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1993
Peptide:
DAEFRHDSGYEVHHQKLVFFAPDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
E693P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
14687578
Reference:
J Mol Biol. 2004 Jan 16;335(3):833-42.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
47.5
NuAPRpred:
-1.74
Tango:
552.21
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.3
Area of the profile Above Threshold (AGGRESCAN):
11.39
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1994 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1994
Peptide:
DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
E693Q
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
7672107
Reference:
FEBS Lett. 1995 Sep 4;371(2):110-4.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
45.0
NuAPRpred:
-0.05
Tango:
917.28
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.1
Area of the profile Above Threshold (AGGRESCAN):
11.1
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1995 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1995
Peptide:
DAEFRHDSGYEVHHQKLVFFMEDVGSNKGAIIGLLVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
A692M, M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
1.54
Tango:
1088.94
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.2
Area of the profile Above Threshold (AGGRESCAN):
12.22
Best Energy Score (PASTA 2.0):
-7.47
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1996 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1996
Peptide:
DAEFRHDSGYEVHHQKLVVFVEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
F690V, A692V
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
2.19
Tango:
937.43
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.3
Area of the profile Above Threshold (AGGRESCAN):
12.13
Best Energy Score (PASTA 2.0):
-7.66
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1997 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1997
Peptide:
DAEFRHDSGYEVHHQKPVFFAEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
L688P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
14687578
Reference:
J Mol Biol. 2004 Jan 16;335(3):833-42.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
-5.69
Tango:
449.87
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.6
Area of the profile Above Threshold (AGGRESCAN):
9.77
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1998 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1998
Peptide:
DAEFRHDSGYEVHHQTLVFFAEDAGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
K687T, V695A
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-4
Absolute Charge:
8
Hydrophobicity:
45.0
NuAPRpred:
-0.76
Tango:
865.94
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.5
Area of the profile Above Threshold (AGGRESCAN):
11.4
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1999 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1999
Peptide:
DAEFRHDSGYEVHHQTLVFFVEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
K687T, A692V
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
14687578
Reference:
J Mol Biol. 2004 Jan 16;335(3):833-42.
source:
CPAD
Derived Information
Net Charge:
-4
Absolute Charge:
8
Hydrophobicity:
45.0
NuAPRpred:
1.47
Tango:
964.05
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.7
Area of the profile Above Threshold (AGGRESCAN):
12.73
Best Energy Score (PASTA 2.0):
-7.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2000 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2000
Peptide:
DAEFRHDSGYEVHHRKLVFFAEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
Q686R
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
10
Hydrophobicity:
45.0
NuAPRpred:
-1.85
Tango:
934.13
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.4
Area of the profile Above Threshold (AGGRESCAN):
10.99
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2001 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2001
Peptide:
DAEFRHDSGYEVHPQKLVFFAEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
H685P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
14687578
Reference:
J Mol Biol. 2004 Jan 16;335(3):833-42.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.5
NuAPRpred:
-4.4
Tango:
874.82
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.4
Area of the profile Above Threshold (AGGRESCAN):
11.12
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2002 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2002
Peptide:
DAEFRHDSGYEVHYQKLVFFAEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
H685Y
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.5
NuAPRpred:
0.56
Tango:
875.07
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.1
Area of the profile Above Threshold (AGGRESCAN):
11.72
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2003 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2003
Peptide:
DAEFRHNSGYEVHYQKLVFFAEDVGSNKGAIIGLMVGGVM
Length:
40
Classification:
Amyloid
Mutation(s):
D678N, H685Y, V711M
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
47.5
NuAPRpred:
0.38
Tango:
875.15
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.4
Area of the profile Above Threshold (AGGRESCAN):
11.31
Best Energy Score (PASTA 2.0):
-5.55
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2004 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2004
Peptide:
DAEPRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
F675P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
14687578
Reference:
J Mol Biol. 2004 Jan 16;335(3):833-42.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
-0.32
Tango:
875.77
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.6
Area of the profile Above Threshold (AGGRESCAN):
10.99
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2005 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2005
Peptide:
DVEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
A673V
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
0.29
Tango:
875.77
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.9
Area of the profile Above Threshold (AGGRESCAN):
10.99
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2006 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2006
Peptide:
DVEFRHDSGYEVHHQKLVFFAEDVGSNKGALIGLLVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
A673V, I702L, M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
45.0
NuAPRpred:
1.3
Tango:
1001.12
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.0
Area of the profile Above Threshold (AGGRESCAN):
11.11
Best Energy Score (PASTA 2.0):
-6.25
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2007 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2007
Peptide:
DVEFRHDSGYEVHHQKLVFFAGDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
A673V, E693G
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
45.0
NuAPRpred:
0.34
Tango:
922.64
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.1
Area of the profile Above Threshold (AGGRESCAN):
11.52
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2008 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2008
Peptide:
GAEFRHDSGYEVHHQKLVFFVEDVGSNKGAIIGLMVGGVV
Length:
40
Classification:
Amyloid
Mutation(s):
D672G, A692V
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-711
Literature
PMID:
18258258
Reference:
J Mol Biol. 2008 Mar 21;377(2):565-74.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
45.0
NuAPRpred:
1.56
Tango:
937.2
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.7
Area of the profile Above Threshold (AGGRESCAN):
12.29
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2009 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2009
Peptide:
DAEFRHDSGYEVHHQKLVAFFEDVGSNKGAIIGLLGGVVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
F690A, A692F, M706L, V707G, G709V
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16293696
Reference:
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.62
NuAPRpred:
2.64
Tango:
1601.6
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.5
Area of the profile Above Threshold (AGGRESCAN):
13.96
Best Energy Score (PASTA 2.0):
-9.44
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-2010 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-2010
Peptide:
DAEFRHDSGYEVHHQKLVAFFEDVGSNKGAIIGLLVGGVVIA
Length:
42
Classification:
Amyloid
Mutation(s):
F690A, A692F, M706L
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-713
Literature
PMID:
16293696
Reference:
Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
47.62
NuAPRpred:
2.86
Tango:
1595.5
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.5
Area of the profile Above Threshold (AGGRESCAN):
13.96
Best Energy Score (PASTA 2.0):
-9.44
Aggregate Orientation (PASTA 2.0):
Parallel
