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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 211 to 240 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0211
FYTPKT
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0212
GAAIGW
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0213
GAAVDQ
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0214
GADVGQ
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0215
GAFSIN
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0216
GAIIGL
6
amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
21949245
Waltz-DB 2.0
P-0217
GAILSS
6
amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
23552370
Waltz-DB 2.0
P-0218
GAITIG
6
Amyloid
No
J Phys Chem B. 2009 Nov 26;113(47):15639-47.
19863125
Waltz-DB 2.0, AmyLoad
P-0219
GATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38G
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0220
GDCFIL
6
Amyloid
Gelsolin (AGEL)
P06396
No
Prion. 2007 Jan-Mar;1(1):9-14.
19164912
CPAD, Waltz-DB 2.0
P-0221
GDHCII
6
Amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0222
GDVIEV
6
amyloid
No
Science. 2012 Mar 9;335(6073):1228-31.
22403391
Waltz-DB 2.0
P-0223
GDVIEW
6
Amyloid
Alpha-crystallin B chain (Alpha(B)-crystallin)
P02511
V100W
Science. 2012 Mar 9;335(6073):1228-31.
22403391
AmyLoad
P-0224
GEATVS
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0225
GELAVA
6
amyloid
No
J Mol Biol. 2018 Oct 12;430(20):3774-3783.
29964045
Waltz-DB 2.0
P-0226
GERGFF
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0227
GEWTYD
6
Amyloid
Immunoglobulin G-binding protein G (IgG-binding protein G)
P06654
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0228
GFFNLQ
6
Non-amyloid
Laminin subunit alpha-2
P24043
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0229
GFFQQQ
6
Amyloid
GRB2-associated-binding protein 1
Q13480
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0230
GFFYTP
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0231
GFGNNA
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0232
GFGNQS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
G287S
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0233
GFGNSA
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0234
GFGNSR
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0235
GFNKFG
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0236
GFNNSA
6
Non-amyloid
Nucleoporin NSP1
P14907
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0237
GFNNTP
6
Non-amyloid
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Q12221
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0238
GFPGSF
6
Non-amyloid
Alpha-galactosidase A
P06280
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0239
GFQPQS
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0240
GFSGSF
6
Non-amyloid
Alpha-galactosidase A
P06280
P146S
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0211 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0211
Peptide:
FYTPKT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
49-54
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-8.9
Area of the profile Above Threshold (AGGRESCAN):
0.77
Best Energy Score (PASTA 2.0):
0.62
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0212 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0212
Peptide:
GAAIGW
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
380-385
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.14
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.1
Area of the profile Above Threshold (AGGRESCAN):
1.15
Best Energy Score (PASTA 2.0):
-1.04
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0213 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0213
Peptide:
GAAVDQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
123-128
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-29.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0214 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0214
Peptide:
GADVGQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
78-83
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-48.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0215 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0215
Peptide:
GAFSIN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
314-319
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.08
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
16.6
Area of the profile Above Threshold (AGGRESCAN):
1.37
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0216 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0216
Peptide:
GAIIGL
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
700-705
Literature
PMID:
21949245
Reference:
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.85
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
55.7
Area of the profile Above Threshold (AGGRESCAN):
3.61
Best Energy Score (PASTA 2.0):
-3.37
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0217 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0217
Peptide:
GAILSS
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
24-29
Literature
PMID:
23552370
Reference:
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.24
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.3
Area of the profile Above Threshold (AGGRESCAN):
2.23
Best Energy Score (PASTA 2.0):
-1.56
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0218 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0218
Peptide:
GAITIG
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
19863125
Reference:
J Phys Chem B. 2009 Nov 26;113(47):15639-47.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
28.3
Area of the profile Above Threshold (AGGRESCAN):
1.99
Best Energy Score (PASTA 2.0):
-3.53
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0219 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0219
Peptide:
GATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38G
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.2
Area of the profile Above Threshold (AGGRESCAN):
2.56
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0220 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0220
Peptide:
GDCFIL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
213-218
Literature
PMID:
19164912
Reference:
Prion. 2007 Jan-Mar;1(1):9-14.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
37.4
Area of the profile Above Threshold (AGGRESCAN):
2.98
Best Energy Score (PASTA 2.0):
-3.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0221 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0221
Peptide:
GDHCII
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
109-114
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.79
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-14.0
Area of the profile Above Threshold (AGGRESCAN):
1.19
Best Energy Score (PASTA 2.0):
-3.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0222 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
G
D
V
I
E
V
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0222
Peptide:
GDVIEV
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
22403391
Reference:
Science. 2012 Mar 9;335(6073):1228-31.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
17.5
Area of the profile Above Threshold (AGGRESCAN):
1.42
Best Energy Score (PASTA 2.0):
-3.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0223 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
I
A
I
H
H
P
W
I
R
R
P
F
F
P
F
H
S
P
S
R
L
F
D
Q
F
F
G
E
H
L
L
E
S
D
L
F
P
T
S
T
S
L
S
P
F
Y
L
R
P
P
S
F
L
R
A
P
S
W
60
61
F
D
T
G
L
S
E
M
R
L
E
K
D
R
F
S
V
N
L
D
V
K
H
F
S
P
E
E
L
K
V
K
V
L
G
D
V
I
E
V
H
G
K
H
E
E
R
Q
D
E
H
G
F
I
S
R
E
F
H
R
120
121
K
Y
R
I
P
A
D
V
D
P
L
T
I
T
S
S
L
S
S
D
G
V
L
T
V
N
G
P
R
K
Q
V
S
G
P
E
R
T
I
P
I
T
R
E
E
K
P
A
V
T
A
A
P
K
K
175
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0223
Peptide:
GDVIEW
Length:
6
Classification:
Amyloid
Mutation(s):
V100W
Structure(s):
No structures
Protein Information
UniProt ID:
P02511
UniProt Name:
CRYAB_HUMAN
Protein Name:
Alpha-crystallin B chain (Alpha(B)-crystallin)
Position:
95-100
Literature
PMID:
22403391
Reference:
Science. 2012 Mar 9;335(6073):1228-31.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.0
Area of the profile Above Threshold (AGGRESCAN):
1.08
Best Energy Score (PASTA 2.0):
-2.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0224 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0224
Peptide:
GEATVS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
335-340
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-27.8
Area of the profile Above Threshold (AGGRESCAN):
0.05
Best Energy Score (PASTA 2.0):
-0.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0225 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
G
E
L
A
V
A
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0225
Peptide:
GELAVA
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
29964045
Reference:
J Mol Biol. 2018 Oct 12;430(20):3774-3783.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.22
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.5
Area of the profile Above Threshold (AGGRESCAN):
1.3
Best Energy Score (PASTA 2.0):
-1.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0226 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0226
Peptide:
GERGFF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
44-49
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.8
Area of the profile Above Threshold (AGGRESCAN):
0.38
Best Energy Score (PASTA 2.0):
0.61
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0227 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
E
K
E
K
K
V
K
Y
F
L
R
K
S
A
F
G
L
A
S
V
S
A
A
F
L
V
G
S
T
V
F
A
V
D
S
P
I
E
D
T
P
I
I
R
N
G
G
E
L
T
N
L
L
G
N
S
E
T
T
60
61
L
A
L
R
N
E
E
S
A
T
A
D
L
T
A
A
A
V
A
D
T
V
A
A
A
A
A
E
N
A
G
A
A
A
W
E
A
A
A
A
A
D
A
L
A
K
A
K
A
D
A
L
K
E
F
N
K
Y
G
V
120
121
S
D
Y
Y
K
N
L
I
N
N
A
K
T
V
E
G
I
K
D
L
Q
A
Q
V
V
E
S
A
K
K
A
R
I
S
E
A
T
D
G
L
S
D
F
L
K
S
Q
T
P
A
E
D
T
V
K
S
I
E
L
A
180
181
E
A
K
V
L
A
N
R
E
L
D
K
Y
G
V
S
D
Y
H
K
N
L
I
N
N
A
K
T
V
E
G
V
K
E
L
I
D
E
I
L
A
A
L
P
K
T
D
T
Y
K
L
I
L
N
G
K
T
L
K
G
240
241
E
T
T
T
E
A
V
D
A
A
T
A
E
K
V
F
K
Q
Y
A
N
D
N
G
V
D
G
E
W
T
Y
D
D
A
T
K
T
F
T
V
T
E
K
P
E
V
I
D
A
S
E
L
T
P
A
V
T
T
Y
K
300
301
L
V
I
N
G
K
T
L
K
G
E
T
T
T
K
A
V
D
A
E
T
A
E
K
A
F
K
Q
Y
A
N
D
N
G
V
D
G
V
W
T
Y
D
D
A
T
K
T
F
T
V
T
E
M
V
T
E
V
P
G
D
360
361
A
P
T
E
P
E
K
P
E
A
S
I
P
L
V
P
L
T
P
A
T
P
I
A
K
D
D
A
K
K
D
D
T
K
K
E
D
A
K
K
P
E
A
K
K
D
D
A
K
K
A
E
T
L
P
T
T
G
E
G
420
421
S
N
P
F
F
T
A
A
A
L
A
V
M
A
G
A
G
A
L
A
V
A
S
K
R
K
E
D
448
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0227
Peptide:
GEWTYD
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06654
UniProt Name:
SPG1_STRSG
Protein Name:
Immunoglobulin G-binding protein G (IgG-binding protein G)
Position:
267-272
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-27.6
Area of the profile Above Threshold (AGGRESCAN):
0.04
Best Energy Score (PASTA 2.0):
-0.69
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0228 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
P
G
A
A
G
V
L
L
L
L
L
L
S
G
G
L
G
G
V
Q
A
Q
R
P
Q
Q
Q
R
Q
S
Q
A
H
Q
Q
R
G
L
F
P
A
V
L
N
L
A
S
N
A
L
I
T
T
N
A
T
C
G
E
60
61
K
G
P
E
M
Y
C
K
L
V
E
H
V
P
G
Q
P
V
R
N
P
Q
C
R
I
C
N
Q
N
S
S
N
P
N
Q
R
H
P
I
T
N
A
I
D
G
K
N
T
W
W
Q
S
P
S
I
K
N
G
I
E
120
121
Y
H
Y
V
T
I
T
L
D
L
Q
Q
V
F
Q
I
A
Y
V
I
V
K
A
A
N
S
P
R
P
G
N
W
I
L
E
R
S
L
D
D
V
E
Y
K
P
W
Q
Y
H
A
V
T
D
T
E
C
L
T
L
Y
180
181
N
I
Y
P
R
T
G
P
P
S
Y
A
K
D
D
E
V
I
C
T
S
F
Y
S
K
I
H
P
L
E
N
G
E
I
H
I
S
L
I
N
G
R
P
S
A
D
D
P
S
P
E
L
L
E
F
T
S
A
R
Y
240
241
I
R
L
R
F
Q
R
I
R
T
L
N
A
D
L
M
M
F
A
H
K
D
P
R
E
I
D
P
I
V
T
R
R
Y
Y
Y
S
V
K
D
I
S
V
G
G
M
C
I
C
Y
G
H
A
R
A
C
P
L
D
P
300
301
A
T
N
K
S
R
C
E
C
E
H
N
T
C
G
D
S
C
D
Q
C
C
P
G
F
H
Q
K
P
W
R
A
G
T
F
L
T
K
T
E
C
E
A
C
N
C
H
G
K
A
E
E
C
Y
Y
D
E
N
V
A
360
361
R
R
N
L
S
L
N
I
R
G
K
Y
I
G
G
G
V
C
I
N
C
T
Q
N
T
A
G
I
N
C
E
T
C
T
D
G
F
F
R
P
K
G
V
S
P
N
Y
P
R
P
C
Q
P
C
H
C
D
P
I
G
420
421
S
L
N
E
V
C
V
K
D
E
K
H
A
R
R
G
L
A
P
G
S
C
H
C
K
T
G
F
G
G
V
S
C
D
R
C
A
R
G
Y
T
G
Y
P
D
C
K
A
C
N
C
S
G
L
G
S
K
N
E
D
480
481
P
C
F
G
P
C
I
C
K
E
N
V
E
G
G
D
C
S
R
C
K
S
G
F
F
N
L
Q
E
D
N
W
K
G
C
D
E
C
F
C
S
G
V
S
N
R
C
Q
S
S
Y
W
T
Y
G
K
I
Q
D
M
540
541
S
G
W
Y
L
T
D
L
P
G
R
I
R
V
A
P
Q
Q
D
D
L
D
S
P
Q
Q
I
S
I
S
N
A
E
A
R
Q
A
L
P
H
S
Y
Y
W
S
A
P
A
P
Y
L
G
N
K
L
P
A
V
G
G
600
601
Q
L
T
F
T
I
S
Y
D
L
E
E
E
E
E
D
T
E
R
V
L
Q
L
M
I
I
L
E
G
N
D
L
S
I
S
T
A
Q
D
E
V
Y
L
H
P
S
E
E
H
T
N
V
L
L
L
K
E
E
S
F
660
661
T
I
H
G
T
H
F
P
V
R
R
K
E
F
M
T
V
L
A
N
L
K
R
V
L
L
Q
I
T
Y
S
F
G
M
D
A
I
F
R
L
S
S
V
N
L
E
S
A
V
S
Y
P
T
D
G
S
I
A
A
A
720
721
V
E
V
C
Q
C
P
P
G
Y
T
G
S
S
C
E
S
C
W
P
R
H
R
R
V
N
G
T
I
F
G
G
I
C
E
P
C
Q
C
F
G
H
A
E
S
C
D
D
V
T
G
E
C
L
N
C
K
D
H
T
780
781
G
G
P
Y
C
D
K
C
L
P
G
F
Y
G
E
P
T
K
G
T
S
E
D
C
Q
P
C
A
C
P
L
N
I
P
S
N
N
F
S
P
T
C
H
L
D
R
S
L
G
L
I
C
D
G
C
P
V
G
Y
T
840
841
G
P
R
C
E
R
C
A
E
G
Y
F
G
Q
P
S
V
P
G
G
S
C
Q
P
C
Q
C
N
D
N
L
D
F
S
I
P
G
S
C
D
S
L
S
G
S
C
L
I
C
K
P
G
T
T
G
R
Y
C
E
L
900
901
C
A
D
G
Y
F
G
D
A
V
D
A
K
N
C
Q
P
C
R
C
N
A
G
G
S
F
S
E
V
C
H
S
Q
T
G
Q
C
E
C
R
A
N
V
Q
G
Q
R
C
D
K
C
K
A
G
T
F
G
L
Q
S
960
961
A
R
G
C
V
P
C
N
C
N
S
F
G
S
K
S
F
D
C
E
E
S
G
Q
C
W
C
Q
P
G
V
T
G
K
K
C
D
R
C
A
H
G
Y
F
N
F
Q
E
G
G
C
T
A
C
E
C
S
H
L
G
1020
1021
N
N
C
D
P
K
T
G
R
C
I
C
P
P
N
T
I
G
E
K
C
S
K
C
A
P
N
T
W
G
H
S
I
T
T
G
C
K
A
C
N
C
S
T
V
G
S
L
D
F
Q
C
N
V
N
T
G
Q
C
N
1080
1081
C
H
P
K
F
S
G
A
K
C
T
E
C
S
R
G
H
W
N
Y
P
R
C
N
L
C
D
C
F
L
P
G
T
D
A
T
T
C
D
S
E
T
K
K
C
S
C
S
D
Q
T
G
Q
C
T
C
K
V
N
V
1140
1141
E
G
I
H
C
D
R
C
R
P
G
K
F
G
L
D
A
K
N
P
L
G
C
S
S
C
Y
C
F
G
T
T
T
Q
C
S
E
A
K
G
L
I
R
T
W
V
T
L
K
A
E
Q
T
I
L
P
L
V
D
E
1200
1201
A
L
Q
H
T
T
T
K
G
I
V
F
Q
H
P
E
I
V
A
H
M
D
L
M
R
E
D
L
H
L
E
P
F
Y
W
K
L
P
E
Q
F
E
G
K
K
L
M
A
Y
G
G
K
L
K
Y
A
I
Y
F
E
1260
1261
A
R
E
E
T
G
F
S
T
Y
N
P
Q
V
I
I
R
G
G
T
P
T
H
A
R
I
I
V
R
H
M
A
A
P
L
I
G
Q
L
T
R
H
E
I
E
M
T
E
K
E
W
K
Y
Y
G
D
D
P
R
V
1320
1321
H
R
T
V
T
R
E
D
F
L
D
I
L
Y
D
I
H
Y
I
L
I
K
A
T
Y
G
N
F
M
R
Q
S
R
I
S
E
I
S
M
E
V
A
E
Q
G
R
G
T
T
M
T
P
P
A
D
L
I
E
K
C
1380
1381
D
C
P
L
G
Y
S
G
L
S
C
E
A
C
L
P
G
F
Y
R
L
R
S
Q
P
G
G
R
T
P
G
P
T
L
G
T
C
V
P
C
Q
C
N
G
H
S
S
L
C
D
P
E
T
S
I
C
Q
N
C
Q
1440
1441
H
H
T
A
G
D
F
C
E
R
C
A
L
G
Y
Y
G
I
V
K
G
L
P
N
D
C
Q
Q
C
A
C
P
L
I
S
S
S
N
N
F
S
P
S
C
V
A
E
G
L
D
D
Y
R
C
T
A
C
P
R
G
1500
1501
Y
E
G
Q
Y
C
E
R
C
A
P
G
Y
T
G
S
P
G
N
P
G
G
S
C
Q
E
C
E
C
D
P
Y
G
S
L
P
V
P
C
D
P
V
T
G
F
C
T
C
R
P
G
A
T
G
R
K
C
D
G
C
1560
1561
K
H
W
H
A
R
E
G
W
E
C
V
F
C
G
D
E
C
T
G
L
L
L
G
D
L
A
R
L
E
Q
M
V
M
S
I
N
L
T
G
P
L
P
A
P
Y
K
M
L
Y
G
L
E
N
M
T
Q
E
L
K
1620
1621
H
L
L
S
P
Q
R
A
P
E
R
L
I
Q
L
A
E
G
N
L
N
T
L
V
T
E
M
N
E
L
L
T
R
A
T
K
V
T
A
D
G
E
Q
T
G
Q
D
A
E
R
T
N
T
R
A
K
S
L
G
E
1680
1681
F
I
K
E
L
A
R
D
A
E
A
V
N
E
K
A
I
K
L
N
E
T
L
G
T
R
D
E
A
F
E
R
N
L
E
G
L
Q
K
E
I
D
Q
M
I
K
E
L
R
R
K
N
L
E
T
Q
K
E
I
A
1740
1741
E
D
E
L
V
A
A
E
A
L
L
K
K
V
K
K
L
F
G
E
S
R
G
E
N
E
E
M
E
K
D
L
R
E
K
L
A
D
Y
K
N
K
V
D
D
A
W
D
L
L
R
E
A
T
D
K
I
R
E
A
1800
1801
N
R
L
F
A
V
N
Q
K
N
M
T
A
L
E
K
K
K
E
A
V
E
S
G
K
R
Q
I
E
N
T
L
K
E
G
N
D
I
L
D
E
A
N
R
L
A
D
E
I
N
S
I
I
D
Y
V
E
D
I
Q
1860
1861
T
K
L
P
P
M
S
E
E
L
N
D
K
I
D
D
L
S
Q
E
I
K
D
R
K
L
A
E
K
V
S
Q
A
E
S
H
A
A
Q
L
N
D
S
S
A
V
L
D
G
I
L
D
E
A
K
N
I
S
F
N
1920
1921
A
T
A
A
F
K
A
Y
S
N
I
K
D
Y
I
D
E
A
E
K
V
A
K
E
A
K
D
L
A
H
E
A
T
K
L
A
T
G
P
R
G
L
L
K
E
D
A
K
G
C
L
Q
K
S
F
R
I
L
N
E
1980
1981
A
K
K
L
A
N
D
V
K
E
N
E
D
H
L
N
G
L
K
T
R
I
E
N
A
D
A
R
N
G
D
L
L
R
T
L
N
D
T
L
G
K
L
S
A
I
P
N
D
T
A
A
K
L
Q
A
V
K
D
K
2040
2041
A
R
Q
A
N
D
T
A
K
D
V
L
A
Q
I
T
E
L
H
Q
N
L
D
G
L
K
K
N
Y
N
K
L
A
D
S
V
A
K
T
N
A
V
V
K
D
P
S
K
N
K
I
I
A
D
A
D
A
T
V
K
2100
2101
N
L
E
Q
E
A
D
R
L
I
D
K
L
K
P
I
K
E
L
E
D
N
L
K
K
N
I
S
E
I
K
E
L
I
N
Q
A
R
K
Q
A
N
S
I
K
V
S
V
S
S
G
G
D
C
I
R
T
Y
K
P
2160
2161
E
I
K
K
G
S
Y
N
N
I
V
V
N
V
K
T
A
V
A
D
N
L
L
F
Y
L
G
S
A
K
F
I
D
F
L
A
I
E
M
R
K
G
K
V
S
F
L
W
D
V
G
S
G
V
G
R
V
E
Y
P
2220
2221
D
L
T
I
D
D
S
Y
W
Y
R
I
V
A
S
R
T
G
R
N
G
T
I
S
V
R
A
L
D
G
P
K
A
S
I
V
P
S
T
H
H
S
T
S
P
P
G
Y
T
I
L
D
V
D
A
N
A
M
L
F
2280
2281
V
G
G
L
T
G
K
L
K
K
A
D
A
V
R
V
I
T
F
T
G
C
M
G
E
T
Y
F
D
N
K
P
I
G
L
W
N
F
R
E
K
E
G
D
C
K
G
C
T
V
S
P
Q
V
E
D
S
E
G
T
2340
2341
I
Q
F
D
G
E
G
Y
A
L
V
S
R
P
I
R
W
Y
P
N
I
S
T
V
M
F
K
F
R
T
F
S
S
S
A
L
L
M
Y
L
A
T
R
D
L
R
D
F
M
S
V
E
L
T
D
G
H
I
K
V
2400
2401
S
Y
D
L
G
S
G
M
A
S
V
V
S
N
Q
N
H
N
D
G
K
W
K
S
F
T
L
S
R
I
Q
K
Q
A
N
I
S
I
V
D
I
D
T
N
Q
E
E
N
I
A
T
S
S
S
G
N
N
F
G
L
2460
2461
D
L
K
A
D
D
K
I
Y
F
G
G
L
P
T
L
R
N
L
S
M
K
A
R
P
E
V
N
L
K
K
Y
S
G
C
L
K
D
I
E
I
S
R
T
P
Y
N
I
L
S
S
P
D
Y
V
G
V
T
K
G
2520
2521
C
S
L
E
N
V
Y
T
V
S
F
P
K
P
G
F
V
E
L
S
P
V
P
I
D
V
G
T
E
I
N
L
S
F
S
T
K
N
E
S
G
I
I
L
L
G
S
G
G
T
P
A
P
P
R
R
K
R
R
Q
2580
2581
T
G
Q
A
Y
Y
A
I
L
L
N
R
G
R
L
E
V
H
L
S
T
G
A
R
T
M
R
K
I
V
I
R
P
E
P
N
L
F
H
D
G
R
E
H
S
V
H
V
E
R
T
R
G
I
F
T
V
Q
V
D
2640
2641
E
N
R
R
Y
M
Q
N
L
T
V
E
Q
P
I
E
V
K
K
L
F
V
G
G
A
P
P
E
F
Q
P
S
P
L
R
N
I
P
P
F
E
G
C
I
W
N
L
V
I
N
S
V
P
M
D
F
A
R
P
V
2700
2701
S
F
K
N
A
D
I
G
R
C
A
H
Q
K
L
R
E
D
E
D
G
A
A
P
A
E
I
V
I
Q
P
E
P
V
P
T
P
A
F
P
T
P
T
P
V
L
T
H
G
P
C
A
A
E
S
E
P
A
L
L
2760
2761
I
G
S
K
Q
F
G
L
S
R
N
S
H
I
A
I
A
F
D
D
T
K
V
K
N
R
L
T
I
E
L
E
V
R
T
E
A
E
S
G
L
L
F
Y
M
A
R
I
N
H
A
D
F
A
T
V
Q
L
R
N
2820
2821
G
L
P
Y
F
S
Y
D
L
G
S
G
D
T
H
T
M
I
P
T
K
I
N
D
G
Q
W
H
K
I
K
I
M
R
S
K
Q
E
G
I
L
Y
V
D
G
A
S
N
R
T
I
S
P
K
K
A
D
I
L
D
2880
2881
V
V
G
M
L
Y
V
G
G
L
P
I
N
Y
T
T
R
R
I
G
P
V
T
Y
S
I
D
G
C
V
R
N
L
H
M
A
E
A
P
A
D
L
E
Q
P
T
S
S
F
H
V
G
T
C
F
A
N
A
Q
R
2940
2941
G
T
Y
F
D
G
T
G
F
A
K
A
V
G
G
F
K
V
G
L
D
L
L
V
E
F
E
F
R
T
T
T
T
T
G
V
L
L
G
I
S
S
Q
K
M
D
G
M
G
I
E
M
I
D
E
K
L
M
F
H
3000
3001
V
D
N
G
A
G
R
F
T
A
V
Y
D
A
G
V
P
G
H
L
C
D
G
Q
W
H
K
V
T
A
N
K
I
K
H
R
I
E
L
T
V
D
G
N
Q
V
E
A
Q
S
P
N
P
A
S
T
S
A
D
T
3060
3061
N
D
P
V
F
V
G
G
F
P
D
D
L
K
Q
F
G
L
T
T
S
I
P
F
R
G
C
I
R
S
L
K
L
T
K
G
T
G
K
P
L
E
V
N
F
A
K
A
L
E
L
R
G
V
Q
P
V
S
C
P
3120
3121
A
N
3122
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0228
Peptide:
GFFNLQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P24043
UniProt Name:
LAMA2_HUMAN
Protein Name:
Laminin subunit alpha-2
Position:
503-508
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.41
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.1
Area of the profile Above Threshold (AGGRESCAN):
1.2
Best Energy Score (PASTA 2.0):
-2.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0229 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
G
G
E
V
V
C
S
G
W
L
R
K
S
P
P
E
K
K
L
K
R
Y
A
W
K
R
R
W
F
V
L
R
S
G
R
L
T
G
D
P
D
V
L
E
Y
Y
K
N
D
H
A
K
K
P
I
R
I
I
60
61
D
L
N
L
C
Q
Q
V
D
A
G
L
T
F
N
K
K
E
F
E
N
S
Y
I
F
D
I
N
T
I
D
R
I
F
Y
L
V
A
D
S
E
E
E
M
N
K
W
V
R
C
I
C
D
I
C
G
F
N
P
T
120
121
E
E
D
P
V
K
P
P
G
S
S
L
Q
A
P
A
D
L
P
L
A
I
N
T
A
P
P
S
T
Q
A
D
S
S
S
A
T
L
P
P
P
Y
Q
L
I
N
V
P
P
H
L
E
T
L
G
I
Q
E
D
P
180
181
Q
D
Y
L
L
L
I
N
C
Q
S
K
K
P
E
P
T
R
T
H
A
D
S
A
K
S
T
S
S
E
T
D
C
N
D
N
V
P
S
H
K
N
P
A
S
S
Q
S
K
H
G
M
N
G
F
F
Q
Q
Q
M
240
241
I
Y
D
S
P
P
S
R
A
P
S
A
S
V
D
S
S
L
Y
N
L
P
R
S
Y
S
H
D
V
L
P
K
V
S
P
S
S
T
E
A
D
G
E
L
Y
V
F
N
T
P
S
G
T
S
S
V
E
T
Q
M
300
301
R
H
V
S
I
S
Y
D
I
P
P
T
P
G
N
T
Y
Q
I
P
R
T
F
P
E
G
T
L
G
Q
T
S
K
L
D
T
I
P
D
I
P
P
P
R
P
P
K
P
H
P
A
H
D
R
S
P
V
E
T
C
360
361
S
I
P
R
T
A
S
D
T
D
S
S
Y
C
I
P
T
A
G
M
S
P
S
R
S
N
T
I
S
T
V
D
L
N
K
L
R
K
D
A
S
S
Q
D
C
Y
D
I
P
R
A
F
P
S
D
R
S
S
S
L
420
421
E
G
F
H
N
H
F
K
V
K
N
V
L
T
V
G
S
V
S
S
E
E
L
D
E
N
Y
V
P
M
N
P
N
S
P
P
R
Q
H
S
S
S
F
T
E
P
I
Q
E
A
N
Y
V
P
M
T
P
G
T
F
480
481
D
F
S
S
F
G
M
Q
V
P
P
P
A
H
M
G
F
R
S
S
P
K
T
P
P
R
R
P
V
P
V
A
D
C
E
P
P
P
V
D
R
N
L
K
P
D
R
K
V
K
P
A
P
L
E
I
K
P
L
P
540
541
E
W
E
E
L
Q
A
P
V
R
S
P
I
T
R
S
F
A
R
D
S
S
R
F
P
M
S
P
R
P
D
S
V
H
S
T
T
S
S
S
D
S
H
D
S
E
E
N
Y
V
P
M
N
P
N
L
S
S
E
D
600
601
P
N
L
F
G
S
N
S
L
D
G
G
S
S
P
M
I
K
P
K
G
D
K
Q
V
E
Y
L
D
L
D
L
D
S
G
K
S
T
P
P
R
K
Q
K
S
S
G
S
G
S
S
V
A
D
E
R
V
D
Y
V
660
661
V
V
D
Q
Q
K
T
L
A
L
K
S
T
R
E
A
W
T
D
G
R
Q
S
T
E
S
E
T
P
A
K
S
V
K
694
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0229
Peptide:
GFFQQQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13480
UniProt Name:
GAB1_HUMAN
Protein Name:
GRB2-associated-binding protein 1
Position:
234-239
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.3
Area of the profile Above Threshold (AGGRESCAN):
0.23
Best Energy Score (PASTA 2.0):
0.01
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0230 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0230
Peptide:
GFFYTP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
47-52
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
52.8
Area of the profile Above Threshold (AGGRESCAN):
3.26
Best Energy Score (PASTA 2.0):
-2.29
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0231 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0231
Peptide:
GFGNNA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
141-146
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.49
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0232 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0232
Peptide:
GFGNQS
Length:
6
Classification:
Non-amyloid
Mutation(s):
G287S
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
282-287
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-56.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.8
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0233 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0233
Peptide:
GFGNSA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
96-101
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-41.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0234 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0234
Peptide:
GFGNSR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
288-293
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-53.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0235 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0235
Peptide:
GFNKFG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
261-266
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.6
Area of the profile Above Threshold (AGGRESCAN):
0.34
Best Energy Score (PASTA 2.0):
-0.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0236 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
F
N
T
P
Q
Q
N
K
T
P
F
S
F
G
T
A
N
N
N
S
N
T
T
N
Q
N
S
S
T
G
A
G
A
F
G
T
G
Q
S
T
F
G
F
N
N
S
A
P
N
N
T
N
N
A
N
S
S
I
60
61
T
P
A
F
G
S
N
N
T
G
N
T
A
F
G
N
S
N
P
T
S
N
V
F
G
S
N
N
S
T
T
N
T
F
G
S
N
S
A
G
T
S
L
F
G
S
S
S
A
Q
Q
T
K
S
N
G
T
A
G
G
120
121
N
T
F
G
S
S
S
L
F
N
N
S
T
N
S
N
T
T
K
P
A
F
G
G
L
N
F
G
G
G
N
N
T
T
P
S
S
T
G
N
A
N
T
S
N
N
L
F
G
A
T
A
N
A
N
K
P
A
F
S
180
181
F
G
A
T
T
N
D
D
K
K
T
E
P
D
K
P
A
F
S
F
N
S
S
V
G
N
K
T
D
A
Q
A
P
T
T
G
F
S
F
G
S
Q
L
G
G
N
K
T
V
N
E
A
A
K
P
S
L
S
F
G
240
241
S
G
S
A
G
A
N
P
A
G
A
S
Q
P
E
P
T
T
N
E
P
A
K
P
A
L
S
F
G
T
A
T
S
D
N
K
T
T
N
T
T
P
S
F
S
F
G
A
K
S
D
E
N
K
A
G
A
T
S
K
300
301
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
360
361
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
P
D
E
N
K
A
S
A
T
S
K
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
420
421
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
S
480
481
D
E
K
K
D
S
D
S
S
K
P
A
F
S
F
G
T
K
S
N
E
K
K
D
S
G
S
S
K
P
A
F
S
F
G
A
K
P
D
E
K
K
N
D
E
V
S
K
P
A
F
S
F
G
A
K
A
N
E
K
540
541
K
E
S
D
E
S
K
S
A
F
S
F
G
S
K
P
T
G
K
E
E
G
D
G
A
K
A
A
I
S
F
G
A
K
P
E
E
Q
K
S
S
D
T
S
K
P
A
F
T
F
G
A
Q
K
D
N
E
K
K
T
600
601
E
E
S
S
T
G
K
S
T
A
D
V
K
S
S
D
S
L
K
L
N
S
K
P
V
E
L
K
P
V
S
L
D
N
K
T
L
D
D
L
V
T
K
W
T
N
Q
L
T
E
S
A
S
H
F
E
Q
Y
T
K
660
661
K
I
N
S
W
D
Q
V
L
V
K
G
G
E
Q
I
S
Q
L
Y
S
D
A
V
M
A
E
H
S
Q
N
K
I
D
Q
S
L
Q
Y
I
E
R
Q
Q
D
E
L
E
N
F
L
D
N
F
E
T
K
T
E
A
720
721
L
L
S
D
V
V
S
T
S
S
G
A
A
A
N
N
N
D
Q
K
R
Q
Q
A
Y
K
T
A
Q
T
L
D
E
N
L
N
S
L
S
S
N
L
S
S
L
I
V
E
I
N
N
V
S
N
T
F
N
K
T
T
780
781
N
I
D
I
N
N
E
D
E
N
I
Q
L
I
K
I
L
N
S
H
F
D
A
L
R
S
L
D
D
N
S
T
S
L
E
K
Q
I
N
S
I
K
K
823
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0236
Peptide:
GFNNSA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14907
UniProt Name:
NSP1_YEAST
Protein Name:
Nucleoporin NSP1
Position:
44-49
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-56.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.18
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0237 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
N
K
R
L
Y
N
G
N
L
S
N
I
P
E
V
I
D
P
G
I
T
I
P
I
Y
E
E
D
I
R
N
D
T
R
M
N
T
N
A
R
S
V
R
V
S
D
K
R
G
R
S
S
S
T
S
P
Q
K
60
61
I
G
S
Y
R
T
R
A
G
R
F
S
D
T
L
T
N
L
L
P
S
I
S
A
K
L
H
H
S
K
K
S
T
P
V
V
V
V
P
P
T
S
S
T
P
D
S
L
N
S
T
T
Y
A
P
R
V
S
S
D
120
121
S
F
T
V
A
T
P
L
S
L
Q
S
T
T
T
R
T
R
T
R
N
N
T
V
S
S
Q
I
T
A
S
S
S
L
T
T
D
V
G
N
A
T
S
A
N
I
W
S
A
N
A
E
S
N
T
S
S
S
P
L
180
181
F
D
Y
P
L
A
T
S
Y
F
E
P
L
T
R
F
K
S
T
D
N
Y
T
L
P
Q
T
A
Q
L
N
S
F
L
E
K
N
G
N
P
N
I
W
S
S
A
G
N
S
N
T
D
H
L
N
T
P
I
V
N
240
241
R
Q
R
S
Q
S
Q
S
T
T
N
R
V
Y
T
D
A
P
Y
Y
Q
Q
P
A
Q
N
Y
Q
V
Q
V
P
P
R
V
P
K
S
T
S
I
S
P
V
I
L
D
D
V
D
P
A
S
I
N
W
I
T
A
N
300
301
Q
K
V
P
L
V
N
Q
I
S
A
L
L
P
T
N
T
I
S
I
S
N
V
F
P
L
Q
P
T
Q
Q
H
Q
Q
N
A
V
N
L
T
S
T
S
L
A
T
L
C
S
Q
Y
G
K
V
L
S
A
R
T
L
360
361
R
G
L
N
M
A
L
V
E
F
S
T
V
E
S
A
I
C
A
L
E
A
L
Q
G
K
E
L
S
K
V
G
A
P
S
T
V
S
F
A
R
V
L
P
M
Y
E
Q
P
L
N
V
N
G
F
N
N
T
P
K
420
421
Q
P
L
L
Q
E
Q
L
N
H
G
V
L
N
Y
Q
L
Q
Q
S
L
Q
Q
P
E
L
Q
Q
Q
P
T
S
F
N
Q
P
N
L
T
Y
C
N
P
T
Q
N
L
S
H
L
Q
L
S
S
N
E
N
E
P
Y
480
481
P
F
P
L
P
P
P
S
L
S
D
S
K
K
D
I
L
H
T
I
S
S
F
K
L
E
Y
D
H
L
E
L
N
H
L
L
Q
N
A
L
K
N
K
G
V
S
D
T
N
Y
F
G
P
L
P
E
H
N
S
K
540
541
V
P
K
R
K
D
T
F
D
A
P
K
L
R
E
L
R
K
Q
F
D
S
N
S
L
S
T
I
E
M
E
Q
L
A
I
V
M
L
D
Q
L
P
E
L
S
S
D
Y
L
G
N
T
V
I
Q
K
L
F
E
N
600
601
S
S
N
I
I
R
D
I
M
L
R
K
C
N
K
Y
L
T
S
M
G
V
H
K
N
G
T
W
V
C
Q
K
I
I
K
M
A
N
T
P
R
Q
I
N
L
V
T
S
G
V
S
D
Y
C
T
P
L
F
N
D
660
661
Q
F
G
N
Y
V
I
Q
G
I
L
K
F
G
F
P
W
N
S
F
I
F
E
S
V
L
S
H
F
W
T
I
V
Q
N
R
Y
G
S
R
A
V
R
A
C
L
E
A
D
S
I
I
T
Q
C
Q
L
L
T
I
720
721
T
S
L
I
I
V
L
S
P
Y
L
A
T
D
T
N
G
T
L
L
I
T
W
L
L
D
T
C
T
L
P
N
K
N
L
I
L
C
D
K
L
V
N
K
N
L
V
K
L
C
C
H
K
L
G
S
L
T
V
L
780
781
K
I
L
N
L
R
G
G
E
E
E
A
L
S
K
N
K
I
I
H
A
I
F
D
G
P
I
S
S
D
S
I
L
F
Q
I
L
D
E
G
N
Y
G
P
T
F
I
Y
K
V
L
T
S
R
I
L
D
N
S
V
840
841
R
D
E
A
I
T
K
I
R
Q
L
I
L
N
S
N
I
N
L
Q
S
R
Q
L
L
E
E
V
G
L
S
S
A
G
I
S
P
K
Q
S
S
K
N
H
R
K
Q
H
P
Q
G
F
H
S
P
G
R
A
R
G
900
901
V
S
V
S
S
V
R
S
S
N
S
R
H
N
S
V
I
Q
M
N
N
A
G
P
T
P
A
L
N
F
N
P
A
P
M
S
E
I
N
S
Y
F
N
N
Q
Q
V
V
Y
S
G
N
Q
N
Q
N
Q
N
G
N
960
961
S
N
G
L
D
E
L
N
S
Q
F
D
S
F
R
I
A
N
G
T
N
L
S
L
P
I
V
N
L
P
N
V
S
N
N
N
N
N
Y
N
N
S
G
Y
S
S
Q
M
N
P
L
S
R
S
V
S
H
N
N
N
1020
1021
N
N
T
N
N
Y
N
N
N
D
N
D
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
S
N
N
S
N
N
N
N
N
N
D
T
S
L
Y
R
Y
R
S
Y
G
Y
1075
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0237
Peptide:
GFNNTP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12221
UniProt Name:
PUF2_YEAST
Protein Name:
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Position:
414-419
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-57.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0238 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
R
N
P
E
L
H
L
G
C
A
L
A
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
A
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
W
E
R
F
M
C
N
L
D
C
Q
E
E
P
60
61
D
S
C
I
S
E
K
L
F
M
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
C
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
P
Q
R
F
P
H
G
I
R
Q
L
120
121
A
N
Y
V
H
S
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
A
D
W
G
V
D
L
L
K
F
D
G
C
Y
C
D
S
L
E
N
L
180
181
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
M
W
P
F
Q
K
P
N
Y
T
E
I
R
Q
Y
C
N
H
W
R
N
F
A
D
I
D
D
S
W
K
S
I
K
240
241
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
D
V
A
G
P
G
G
W
N
D
P
D
M
L
V
I
G
N
F
G
L
S
W
N
Q
Q
V
T
Q
M
A
L
W
A
I
M
A
A
P
L
F
M
S
N
D
L
300
301
R
H
I
S
P
Q
A
K
A
L
L
Q
D
K
D
V
I
A
I
N
Q
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
F
E
V
W
E
R
P
L
S
G
L
A
W
A
V
A
M
I
N
R
Q
E
I
G
360
361
G
P
R
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
N
P
A
C
F
I
T
Q
L
L
P
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
T
420
421
M
Q
M
S
L
K
D
L
L
429
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0238
Peptide:
GFPGSF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06280
UniProt Name:
AGAL_HUMAN
Protein Name:
Alpha-galactosidase A
Position:
144-149
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.8
Area of the profile Above Threshold (AGGRESCAN):
0.49
Best Energy Score (PASTA 2.0):
1.79
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0239 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0239
Peptide:
GFQPQS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
116-121
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-50.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.29
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0240 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
R
N
P
E
L
H
L
G
C
A
L
A
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
A
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
W
E
R
F
M
C
N
L
D
C
Q
E
E
P
60
61
D
S
C
I
S
E
K
L
F
M
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
C
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
P
Q
R
F
P
H
G
I
R
Q
L
120
121
A
N
Y
V
H
S
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
A
D
W
G
V
D
L
L
K
F
D
G
C
Y
C
D
S
L
E
N
L
180
181
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
M
W
P
F
Q
K
P
N
Y
T
E
I
R
Q
Y
C
N
H
W
R
N
F
A
D
I
D
D
S
W
K
S
I
K
240
241
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
D
V
A
G
P
G
G
W
N
D
P
D
M
L
V
I
G
N
F
G
L
S
W
N
Q
Q
V
T
Q
M
A
L
W
A
I
M
A
A
P
L
F
M
S
N
D
L
300
301
R
H
I
S
P
Q
A
K
A
L
L
Q
D
K
D
V
I
A
I
N
Q
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
F
E
V
W
E
R
P
L
S
G
L
A
W
A
V
A
M
I
N
R
Q
E
I
G
360
361
G
P
R
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
N
P
A
C
F
I
T
Q
L
L
P
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
T
420
421
M
Q
M
S
L
K
D
L
L
429
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0240
Peptide:
GFSGSF
Length:
6
Classification:
Non-amyloid
Mutation(s):
P146S
Structure(s):
No structures
Protein Information
UniProt ID:
P06280
UniProt Name:
AGAL_HUMAN
Protein Name:
Alpha-galactosidase A
Position:
144-149
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.31
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.0
Area of the profile Above Threshold (AGGRESCAN):
0.54
Best Energy Score (PASTA 2.0):
-0.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
