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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 961 to 990 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0961
SALALQ
6
Amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0962
SASNAG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0963
SATLDQ
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0964
SATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38S
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0965
SAVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0966
SCNNNN
6
Non-amyloid
Transcriptional regulatory protein SAP30
P38429
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0967
SCPSGN
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
G348C
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0968
SDKKEE
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0969
SDLSFS
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0970
SDLTIT
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0971
SDNNTI
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0972
SDSNQG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0973
SDVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0974
SELNIY
6
Amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0975
SELPKV
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0976
SEMTVK
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0977
SEVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0978
SFFCII
6
Non-amyloid
Hedgehog-interacting protein (HHIP) (HIP)
Q96QV1
CPAD, WALTZ
P-0979
SFFFIQ
6
Amyloid
Unconventional myosin-XV (Unconventional myosin-15)
Q9UKN7
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0980
SFLIFL
6
Amyloid
Major prion protein (PrP)
P04156
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0981
SFQIYA
6
Amyloid
Cystatin-C
P01034
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0982
SFVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0983
SGAAIG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0984
SGDGSL
6
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-0985
SGDHCI
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0986
SGFGNS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
G287S
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0987
SGFHPS
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0988
SGIKLA
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0989
SGSGFN
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0990
SGSNSG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0961 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0961
Peptide:
SALALQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
55-60
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
11.5
Area of the profile Above Threshold (AGGRESCAN):
1.01
Best Energy Score (PASTA 2.0):
-0.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0962 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0962
Peptide:
SASNAG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
387-392
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-59.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0963 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0963
Peptide:
SATLDQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
100-105
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-33.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0964 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0964
Peptide:
SATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38S
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.6
Area of the profile Above Threshold (AGGRESCAN):
2.6
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0965 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0965
Peptide:
SAVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.89
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
57.0
Area of the profile Above Threshold (AGGRESCAN):
3.7
Best Energy Score (PASTA 2.0):
-5.45
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0966 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
R
P
V
N
T
N
A
E
T
E
S
R
G
R
P
T
Q
G
G
G
Y
A
S
N
N
N
G
S
C
N
N
N
N
G
S
N
N
N
N
N
N
N
N
N
N
N
N
N
S
N
N
S
N
N
N
N
G
P
60
61
T
S
S
G
R
T
N
G
K
Q
R
L
T
A
A
Q
Q
Q
Y
I
K
N
L
I
E
T
H
I
T
D
N
H
P
D
L
R
P
K
S
H
P
M
D
F
E
E
Y
T
D
A
F
L
R
R
Y
K
D
H
F
Q
120
121
L
D
V
P
D
N
L
T
L
Q
G
Y
L
L
G
S
K
L
G
A
K
T
Y
S
Y
K
R
N
T
Q
G
Q
H
D
K
R
I
H
K
R
D
L
A
N
V
V
R
R
H
F
D
E
H
S
I
K
E
T
D
C
180
181
I
P
Q
F
I
Y
K
V
K
N
Q
K
K
K
F
K
M
E
F
R
G
201
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0966
Peptide:
SCNNNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P38429
UniProt Name:
SAP30_YEAST
Protein Name:
Transcriptional regulatory protein SAP30
Position:
30-35
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
0.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-95.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.0
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0967 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0967
Peptide:
SCPSGN
Length:
6
Classification:
Non-amyloid
Mutation(s):
G348C
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
347-352
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-45.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.76
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0968 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0968
Peptide:
SDKKEE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
168-173
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
0.0
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-115.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.81
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0969 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0969
Peptide:
SDLSFS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
72-77
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.3
Area of the profile Above Threshold (AGGRESCAN):
0.95
Best Energy Score (PASTA 2.0):
-0.31
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0970 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0970
Peptide:
SDLTIT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
66-71
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.6
Area of the profile Above Threshold (AGGRESCAN):
1.19
Best Energy Score (PASTA 2.0):
-2.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0971 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0971
Peptide:
SDNNTI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
282-287
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-81.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-2.01
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0972 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0972
Peptide:
SDSNQG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
2-7
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-99.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.03
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0973 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0973
Peptide:
SDVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.0
Area of the profile Above Threshold (AGGRESCAN):
2.2
Best Energy Score (PASTA 2.0):
-4.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0974 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0974
Peptide:
SELNIY
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
43-48
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.4
Area of the profile Above Threshold (AGGRESCAN):
1.24
Best Energy Score (PASTA 2.0):
-3.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0975 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0975
Peptide:
SELPKV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
210-215
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.4
Area of the profile Above Threshold (AGGRESCAN):
0.29
Best Energy Score (PASTA 2.0):
1.95
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0976 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0976
Peptide:
SEMTVK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
111-116
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.9
Area of the profile Above Threshold (AGGRESCAN):
0.34
Best Energy Score (PASTA 2.0):
-2.38
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0977 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0977
Peptide:
SEVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.81
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.7
Area of the profile Above Threshold (AGGRESCAN):
2.46
Best Energy Score (PASTA 2.0):
-3.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0978 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0978
Peptide:
SFFCII
Length:
6
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q96QV1
UniProt Name:
HHIP_HUMAN
Protein Name:
Hedgehog-interacting protein (HHIP) (HIP)
Position:
Literature
PMID:
Reference:
source:
CPAD, WALTZ
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.07
Tango:
0.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
92.1
Area of the profile Above Threshold (AGGRESCAN):
5.87
Best Energy Score (PASTA 2.0):
-5.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0979 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
K
E
E
D
E
E
K
K
A
K
K
G
K
K
G
K
K
A
P
E
P
E
K
P
K
R
S
L
K
G
T
S
R
L
F
M
G
F
R
D
R
T
P
K
I
S
K
K
G
Q
F
R
S
A
S
A
F
F
60
61
W
G
L
H
T
G
P
Q
K
T
K
R
K
R
K
A
R
T
V
L
K
S
T
S
K
L
M
T
Q
M
R
M
G
K
K
K
R
A
M
K
G
K
K
P
S
F
M
V
I
R
F
P
G
R
R
G
Y
G
R
L
120
121
R
P
R
A
R
S
L
S
K
A
S
T
A
I
N
W
L
T
K
K
F
L
L
K
K
A
E
E
S
G
S
E
Q
A
T
V
D
A
W
L
Q
R
S
S
S
R
M
G
S
R
K
L
P
F
P
S
G
A
E
I
180
181
L
R
P
G
G
R
L
R
R
F
P
R
S
R
S
I
Y
A
S
G
E
P
L
G
F
L
P
F
E
D
E
A
P
F
H
H
S
G
S
R
K
S
L
Y
G
L
E
G
F
Q
D
L
G
E
Y
Y
D
Y
H
R
240
241
D
G
D
D
Y
Y
D
R
Q
S
L
H
R
Y
E
E
Q
E
P
Y
L
A
G
L
G
P
Y
S
P
A
W
P
P
Y
G
D
H
Y
Y
G
Y
P
P
E
D
P
Y
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Y
G
G
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300
301
P
G
Y
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Y
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L
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Y
360
361
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T
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420
421
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Y
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480
481
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R
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A
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Y
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R
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R
540
541
N
L
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G
L
G
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G
P
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K
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I
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G
P
600
601
A
V
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A
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L
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M
D
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S
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N
D
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R
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P
A
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P
A
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L
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H
W
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L
660
661
L
S
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P
V
P
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R
P
P
S
S
G
P
P
P
A
P
P
L
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L
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H
P
P
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W
A
A
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A
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P
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W
W
A
720
721
F
V
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P
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P
E
V
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P
D
L
L
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P
G
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A
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A
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R
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W
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L
A
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P
S
L
780
781
R
S
S
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G
L
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Y
C
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L
A
P
P
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L
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840
841
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G
S
P
R
P
P
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P
P
L
G
L
C
H
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R
S
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L
N
L
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L
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P
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A
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A
W
900
901
R
A
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L
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H
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R
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P
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D
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W
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W
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G
G
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V
P
960
961
E
N
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F
L
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L
L
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V
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T
L
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D
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A
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T
P
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L
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D
1020
1021
P
Q
L
P
A
E
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K
P
P
T
P
A
P
P
K
D
V
T
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S
L
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Y
P
L
A
A
C
D
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A
T
W
P
P
W
H
R
1080
1081
W
G
T
L
P
Q
A
A
A
P
L
A
P
I
R
A
P
E
P
L
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G
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V
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L
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V
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1140
1141
P
I
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D
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P
R
A
C
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L
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W
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C
L
W
L
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W
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G
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G
A
A
C
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L
R
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W
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P
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W
1200
1201
R
N
K
M
H
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L
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S
M
R
F
R
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H
G
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L
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L
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S
N
L
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I
L
V
1260
1261
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V
N
P
Y
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M
F
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G
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V
Q
Q
Y
N
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A
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P
P
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L
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A
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M
L
D
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N
Q
C
I
I
I
S
G
E
S
G
S
G
1320
1321
K
T
E
A
T
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L
I
L
R
Y
L
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A
M
N
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R
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L
L
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F
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A
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R
N
D
N
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E
1380
1381
G
G
V
I
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G
A
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Y
L
L
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K
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R
I
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A
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N
Y
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L
L
A
G
L
P
A
Q
L
R
Q
A
F
S
L
Q
E
A
E
T
Y
Y
Y
L
N
Q
1440
1441
G
G
N
C
E
I
A
G
K
S
D
A
D
D
F
R
R
L
L
A
A
M
E
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L
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F
S
S
E
D
Q
D
S
I
F
R
I
L
A
S
I
L
H
L
G
N
V
Y
F
E
K
Y
E
T
D
A
Q
E
V
1500
1501
A
S
V
V
S
A
R
E
I
Q
A
V
A
E
L
L
Q
I
S
P
E
G
L
Q
K
A
I
T
F
K
V
T
E
T
M
R
E
K
I
F
T
P
L
T
V
E
S
A
V
D
A
R
D
A
I
A
K
V
L
Y
1560
1561
A
L
L
F
S
W
L
I
T
R
V
N
A
L
V
S
P
R
Q
D
T
L
S
I
A
I
L
D
I
Y
G
F
E
D
L
S
F
N
S
F
E
Q
L
C
I
N
Y
A
N
E
N
L
Q
Y
L
F
N
K
I
V
1620
1621
F
Q
E
E
Q
E
E
Y
I
R
E
Q
I
D
W
Q
E
I
T
F
A
D
N
Q
P
C
I
N
L
I
S
L
K
P
Y
G
I
L
R
I
L
D
D
Q
C
C
F
P
Q
A
T
D
H
T
F
L
Q
K
C
H
1680
1681
Y
H
H
G
A
N
P
L
Y
S
K
P
K
M
P
L
P
E
F
T
I
K
H
Y
A
G
K
V
T
Y
Q
V
H
K
F
L
D
K
N
H
D
Q
V
R
Q
D
V
L
D
L
F
V
R
S
R
T
R
V
V
A
1740
1741
H
L
F
S
S
H
A
P
Q
A
A
P
Q
R
L
G
K
S
S
S
V
T
R
L
Y
K
A
H
T
V
A
A
K
F
Q
Q
S
L
L
D
L
V
E
K
M
E
R
C
N
P
L
F
M
R
C
L
K
P
N
H
1800
1801
K
K
E
P
G
L
F
E
P
D
V
V
M
A
Q
L
R
Y
S
G
V
L
E
T
V
R
I
R
K
E
G
F
P
V
R
L
P
F
Q
G
F
I
D
R
Y
C
C
L
V
A
L
K
H
D
L
P
A
N
G
D
1860
1861
M
C
V
S
V
L
S
R
L
C
K
V
M
P
N
M
Y
R
V
G
V
S
K
L
F
L
K
E
H
L
Y
Q
L
L
E
S
M
R
E
H
V
L
N
L
A
A
L
T
L
Q
R
C
L
R
G
F
F
I
K
R
1920
1921
R
F
R
S
L
R
H
K
I
I
L
L
Q
S
R
A
R
G
Y
L
A
R
Q
R
Y
Q
Q
M
R
R
S
L
V
K
F
R
S
L
V
H
A
Y
V
S
R
R
R
Y
L
K
L
R
A
E
W
R
C
Q
V
E
1980
1981
G
A
L
L
W
E
Q
E
E
L
S
K
R
E
V
V
A
V
G
H
L
E
V
P
A
E
L
A
G
L
L
Q
A
V
A
G
L
G
L
A
Q
V
P
Q
V
A
P
V
R
T
P
R
L
Q
A
E
P
R
V
T
2040
2041
L
P
L
D
I
N
N
Y
P
M
A
K
F
V
Q
C
H
F
K
E
P
A
F
G
M
L
T
V
P
L
R
T
P
L
T
Q
L
P
A
E
H
H
A
E
A
V
S
I
F
K
L
I
L
R
F
M
G
D
P
H
2100
2101
L
H
G
A
R
E
N
I
F
G
N
Y
I
V
Q
K
G
L
A
V
P
E
L
R
D
E
I
L
A
Q
L
A
N
Q
V
W
H
N
H
N
A
H
N
A
E
R
G
W
L
L
L
A
A
C
L
S
G
F
A
P
2160
2161
S
P
C
F
N
K
Y
L
L
K
F
V
S
D
Y
G
R
N
G
F
Q
A
V
C
Q
H
R
L
M
Q
A
M
G
R
A
Q
Q
Q
G
S
G
A
A
R
T
L
P
P
T
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L
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W
T
A
T
Y
E
K
A
2220
2221
S
M
A
L
D
V
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C
F
N
G
D
Q
F
S
C
P
V
H
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W
S
T
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A
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I
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L
A
D
G
W
R
G
W
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A
M
K
N
G
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W
A
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L
A
G
H
2280
2281
D
Y
V
L
D
L
V
S
D
L
E
L
L
R
D
F
P
R
Q
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Y
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T
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P
A
A
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G
G
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V
V
F
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N
S
W
D
S
D
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D
M
S
T
R
P
Q
P
Q
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H
2340
2341
M
P
K
V
L
D
S
D
G
Y
S
S
H
N
Q
D
G
T
N
G
E
T
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A
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T
A
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D
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L
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P
A
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P
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L
D
C
Y
L
D
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L
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D
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V
L
S
2400
2401
Y
G
D
A
D
L
E
K
P
T
A
I
A
Y
R
M
K
G
G
G
Q
P
G
G
G
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R
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2460
2461
Q
A
V
L
L
A
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T
A
L
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Q
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V
G
T
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L
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P
2520
2521
L
A
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A
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A
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A
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2580
2581
R
Q
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Q
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G
R
P
E
A
L
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D
G
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A
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V
2640
2641
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2700
2701
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2760
2761
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V
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2820
2821
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A
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2880
2881
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D
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G
Y
S
A
G
C
V
V
R
R
K
V
V
Y
L
E
E
L
R
R
R
G
P
D
F
G
W
R
F
G
T
I
H
G
R
V
2940
2941
G
R
F
P
S
E
L
V
Q
P
A
A
A
P
D
F
L
Q
L
P
T
E
P
G
R
G
R
A
A
A
V
A
A
A
V
A
S
A
A
A
A
Q
E
V
G
R
R
R
E
G
P
P
V
R
A
R
S
A
D
H
3000
3001
G
E
D
A
L
A
L
P
P
Y
T
M
L
E
F
A
Q
K
Y
F
R
D
P
Q
R
R
P
Q
D
G
L
R
L
K
S
K
E
P
R
E
S
R
T
L
E
D
M
L
C
F
T
K
T
P
L
Q
E
S
L
I
3060
3061
E
L
S
D
S
S
L
S
K
M
A
T
D
M
F
L
A
V
M
R
F
M
G
D
A
P
L
K
G
Q
S
D
L
D
V
L
C
N
L
L
K
L
C
G
D
H
E
V
M
R
D
E
C
Y
C
Q
V
V
K
Q
3120
3121
I
T
D
N
T
S
S
K
Q
D
S
C
Q
R
G
W
R
L
L
Y
I
V
T
A
Y
H
S
C
S
E
V
L
H
P
H
L
T
R
F
L
Q
D
V
S
R
T
P
G
L
P
F
Q
G
I
A
K
A
C
E
Q
3180
3181
N
L
Q
K
T
L
R
F
G
G
R
L
E
L
P
S
S
I
E
L
R
A
M
L
A
G
R
S
S
K
R
Q
L
F
L
L
P
G
G
L
E
R
H
L
K
I
K
T
C
T
V
A
L
D
V
V
E
E
I
C
3240
3241
A
E
M
A
L
T
R
P
E
A
F
N
E
Y
V
I
F
V
V
T
N
R
G
Q
H
V
C
P
L
S
R
R
A
Y
I
L
D
V
A
S
E
M
E
Q
V
D
G
G
Y
M
L
W
F
R
R
V
L
W
D
Q
3300
3301
P
L
K
F
E
N
E
L
Y
V
T
M
H
Y
N
Q
V
L
P
D
Y
L
K
G
L
F
S
S
V
P
A
S
R
P
S
E
Q
L
L
Q
Q
V
S
K
L
A
S
L
Q
H
R
A
K
D
H
F
Y
L
P
S
3360
3361
V
R
E
V
Q
E
Y
I
P
A
Q
L
Y
R
T
T
A
G
S
T
W
L
N
L
V
S
Q
H
R
Q
Q
T
Q
A
L
S
P
H
Q
A
R
A
Q
F
L
G
L
L
S
A
L
P
M
F
G
S
S
F
F
F
3420
3421
I
Q
S
C
S
N
I
A
V
P
A
P
C
I
L
A
I
N
H
N
G
L
N
F
L
S
T
E
T
H
E
L
M
V
K
F
P
L
K
E
I
Q
S
T
R
T
Q
R
P
T
A
N
S
S
Y
P
Y
V
E
I
3480
3481
A
L
G
D
V
A
A
Q
R
T
L
Q
L
Q
L
E
Q
G
L
E
L
C
R
V
V
A
V
H
V
E
N
L
L
S
A
H
E
K
R
L
T
L
P
P
S
E
I
T
L
L
3530
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0979
Peptide:
SFFFIQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q9UKN7
UniProt Name:
MYO15_HUMAN
Protein Name:
Unconventional myosin-XV (Unconventional myosin-15)
Position:
3417-3422
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.88
Tango:
10.69
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
84.5
Area of the profile Above Threshold (AGGRESCAN):
5.54
Best Energy Score (PASTA 2.0):
-4.64
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0980 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0980
Peptide:
SFLIFL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
245-250
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.01
Tango:
11.02
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
103.6
Area of the profile Above Threshold (AGGRESCAN):
6.65
Best Energy Score (PASTA 2.0):
-5.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0981 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
P
L
R
A
P
L
L
L
L
A
I
L
A
V
A
L
A
V
S
P
A
A
G
S
S
P
G
K
P
P
R
L
V
G
G
P
M
D
A
S
V
E
E
E
G
V
R
R
A
L
D
F
A
V
G
E
Y
60
61
N
K
A
S
N
D
M
Y
H
S
R
A
L
Q
V
V
R
A
R
K
Q
I
V
A
G
V
N
Y
F
L
D
V
E
L
G
R
T
T
C
T
K
T
Q
P
N
L
D
N
C
P
F
H
D
Q
P
H
L
K
R
K
120
121
A
F
C
S
F
Q
I
Y
A
V
P
W
Q
G
T
M
T
L
S
K
S
T
C
Q
D
A
146
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0981
Peptide:
SFQIYA
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01034
UniProt Name:
CYTC_HUMAN
Protein Name:
Cystatin-C
Position:
124-129
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
29.3
Area of the profile Above Threshold (AGGRESCAN):
1.93
Best Energy Score (PASTA 2.0):
-1.86
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0982 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0982
Peptide:
SFVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
1.01
Tango:
3.8
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
80.9
Area of the profile Above Threshold (AGGRESCAN):
5.31
Best Energy Score (PASTA 2.0):
-6.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0983 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0983
Peptide:
SGAAIG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
379-384
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-10.6
Area of the profile Above Threshold (AGGRESCAN):
0.45
Best Energy Score (PASTA 2.0):
0.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0984 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0984
Peptide:
SGDGSL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
7-12
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-65.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0985 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0985
Peptide:
SGDHCI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
108-113
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-59.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.47
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0986 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0986
Peptide:
SGFGNS
Length:
6
Classification:
Non-amyloid
Mutation(s):
G287S
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
287-292
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0987 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0987
Peptide:
SGFHPS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
48-53
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-21.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.6
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0988 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0988
Peptide:
SGIKLA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
150-155
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.27
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.7
Area of the profile Above Threshold (AGGRESCAN):
1.17
Best Energy Score (PASTA 2.0):
-0.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0989 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0989
Peptide:
SGSGFN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
393-398
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-34.3
Area of the profile Above Threshold (AGGRESCAN):
0.04
Best Energy Score (PASTA 2.0):
1.12
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0990 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0990
Peptide:
SGSNSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
375-380
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-69.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.99
Aggregate Orientation (PASTA 2.0):
Antiparallel
