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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 991 to 1020 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0991
SGVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0992
SGYQQG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0993
SHLVEA
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0994
SHVIIE
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
Waltz-DB 2.0, AmyLoad
P-0995
SIDLTQ
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0996
SIEDSV
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0997
SINPAM
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0998
SIVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0999
SKVIIE
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
Waltz-DB 2.0, AmyLoad
P-1000
SLFLIG
6
Non-amyloid
Beta/gamma crystallin domain-containing protein 1 (Absent in melanoma 1 protein)
Q9Y4K1
CPAD, WALTZ
P-1001
SLNDFQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1002
SLSGDH
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1003
SLVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1004
SLYQLE
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1005
SMVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1006
SMVLFS
6
Amyloid
Major prion protein (PrP)
P04156
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1007
SNAGSG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1008
SNGIVI
6
Non-amyloid
Agglutinin-like protein 1 (Adhesin 1)
Q5A8T4
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1009
SNMGGG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1010
SNNFGA
6
Non-amyloid
No
J Mol Biol. 2002 May 3;318(3):697-706
12054816
Waltz-DB 2.0, AmyLoad
P-1011
SNNSNI
6
Non-amyloid
Transcriptional activator/repressor MOT3
P54785
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1012
SNQGNN
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1013
SNQNNF
6
Amyloid
Major prion protein (PrP)
P04156
No
Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29
17468747
CPAD, Waltz-DB 2.0, AmyLoad
P-1014
SNSGAA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1015
SNTNNT
6
Non-amyloid
Glucose repression mediator protein CYC8
P14922
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1016
SNVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1017
SPVIIE
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1018
SQAIIH
6
Amyloid
No
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-1019
SQFYIT
6
Amyloid
YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113)
P49750
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1020
SQGMSL
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0991 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0991
Peptide:
SGVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.79
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
50.4
Area of the profile Above Threshold (AGGRESCAN):
3.25
Best Energy Score (PASTA 2.0):
-4.61
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0992 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0992
Peptide:
SGYQQG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
53-58
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-51.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.64
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0993 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0993
Peptide:
SHLVEA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
33-38
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.04
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.5
Area of the profile Above Threshold (AGGRESCAN):
0.46
Best Energy Score (PASTA 2.0):
-2.01
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0994 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0994
Peptide:
SHVIIE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.87
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
43.7
Area of the profile Above Threshold (AGGRESCAN):
2.8
Best Energy Score (PASTA 2.0):
-5.87
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0995 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0995
Peptide:
SIDLTQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
89-94
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.3
Area of the profile Above Threshold (AGGRESCAN):
0.22
Best Energy Score (PASTA 2.0):
-1.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0996 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0996
Peptide:
SIEDSV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
99-104
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-49.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.27
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0997 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0997
Peptide:
SINPAM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
317-322
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.63
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0998 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0998
Peptide:
SIVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
1.05
Tango:
3.38
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
81.8
Area of the profile Above Threshold (AGGRESCAN):
5.37
Best Energy Score (PASTA 2.0):
-7.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0999 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0999
Peptide:
SKVIIE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
45.1
Area of the profile Above Threshold (AGGRESCAN):
2.89
Best Energy Score (PASTA 2.0):
-4.61
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1000 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1000
Peptide:
SLFLIG
Length:
6
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q9Y4K1
UniProt Name:
AIM1_HUMAN
Protein Name:
Beta/gamma crystallin domain-containing protein 1 (Absent in melanoma 1 protein)
Position:
Literature
PMID:
Reference:
source:
CPAD, WALTZ
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.89
Tango:
2.15
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
79.0
Area of the profile Above Threshold (AGGRESCAN):
5.13
Best Energy Score (PASTA 2.0):
-4.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1001 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1001
Peptide:
SLNDFQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
125-130
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1002 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1002
Peptide:
SLSGDH
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
106-111
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1003 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1003
Peptide:
SLVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
1.03
Tango:
1.7
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
75.9
Area of the profile Above Threshold (AGGRESCAN):
4.97
Best Energy Score (PASTA 2.0):
-6.71
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1004 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1004
Peptide:
SLYQLE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
101-106
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.2
Area of the profile Above Threshold (AGGRESCAN):
0.77
Best Energy Score (PASTA 2.0):
-0.57
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1005 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1005
Peptide:
SMVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.85
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
69.6
Area of the profile Above Threshold (AGGRESCAN):
4.55
Best Energy Score (PASTA 2.0):
-6.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1006 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1006
Peptide:
SMVLFS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
231-236
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
71.1
Area of the profile Above Threshold (AGGRESCAN):
4.59
Best Energy Score (PASTA 2.0):
-3.83
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1007 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1007
Peptide:
SNAGSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
389-394
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-59.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1008 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
Q
Q
F
T
L
L
F
L
Y
L
S
I
A
S
A
K
T
I
T
G
V
F
D
S
F
N
S
L
T
W
S
N
A
A
N
Y
A
F
K
G
P
G
Y
P
T
W
N
A
V
L
G
W
S
L
D
G
T
S
60
61
A
N
P
G
D
T
F
T
L
N
M
P
C
V
F
K
Y
T
T
S
Q
T
S
V
D
L
T
A
D
G
V
K
Y
A
T
C
Q
F
Y
S
G
E
E
F
T
T
F
S
T
L
T
C
T
V
N
D
A
L
K
S
120
121
S
I
K
A
F
G
T
V
T
L
P
I
A
F
N
V
G
G
T
G
S
S
T
D
L
E
D
S
K
C
F
T
A
G
T
N
T
V
T
F
N
D
G
D
K
D
I
S
I
D
V
E
F
E
K
S
T
V
D
P
180
181
S
G
Y
L
Y
A
S
R
V
M
P
S
L
N
K
V
T
T
L
F
V
A
P
Q
C
E
N
G
Y
T
S
G
T
M
G
F
S
S
S
N
G
D
V
A
I
D
C
S
N
I
H
I
G
I
T
K
G
L
N
D
240
241
W
N
Y
P
V
S
S
E
S
F
S
Y
T
K
T
C
T
S
N
G
I
Q
I
K
Y
Q
N
V
P
A
G
Y
R
P
F
I
D
A
Y
I
S
A
T
D
V
N
Q
Y
T
L
A
Y
T
N
D
Y
T
C
A
G
300
301
S
R
S
Q
S
K
P
F
T
L
R
W
T
G
Y
K
N
S
D
A
G
S
N
G
I
V
I
V
A
T
T
R
T
V
T
D
S
T
T
A
V
T
T
L
P
F
N
P
S
V
D
K
T
K
T
I
E
I
L
Q
360
361
P
I
P
T
T
T
I
T
T
S
Y
V
G
V
T
T
S
Y
S
T
K
T
A
P
I
G
E
T
A
T
V
I
V
D
V
P
Y
H
T
T
T
T
V
T
S
E
W
T
G
T
I
T
T
T
T
T
R
T
N
P
420
421
T
D
S
I
D
T
V
V
V
Q
V
P
S
P
N
P
T
V
S
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
480
481
S
Q
S
F
A
T
T
T
T
V
T
A
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
540
541
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
I
T
A
600
601
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
660
661
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
720
721
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
F
A
T
T
T
T
V
T
A
780
781
P
P
G
G
T
D
T
V
I
I
Y
E
S
M
S
S
S
K
I
S
T
S
S
N
D
I
T
S
I
I
P
S
F
S
R
P
H
Y
V
N
S
T
T
S
D
L
S
T
F
E
S
S
S
M
N
T
P
T
S
I
840
841
S
S
D
G
M
L
L
S
S
T
T
L
V
T
E
S
E
T
T
T
E
S
I
C
S
D
G
K
E
C
S
R
L
S
S
S
S
G
I
V
T
N
P
D
S
N
E
S
S
I
V
T
S
T
V
P
T
A
S
T
900
901
M
S
D
S
L
S
S
T
D
G
I
S
A
T
S
S
D
N
V
S
K
S
G
V
S
V
T
T
E
T
S
V
T
T
I
Q
T
T
P
N
P
L
S
S
S
V
T
S
L
T
Q
L
S
S
I
P
S
V
S
E
960
961
S
E
S
K
V
T
F
T
S
N
G
D
N
Q
S
G
T
H
D
S
Q
S
T
S
T
E
I
E
I
V
T
T
S
S
T
K
V
L
P
P
V
V
S
S
N
T
D
L
T
S
E
P
T
N
T
R
E
Q
P
T
1020
1021
T
L
S
T
T
S
N
S
I
T
E
D
I
T
T
S
Q
P
T
G
D
N
G
D
N
T
S
S
T
N
P
V
P
T
V
A
T
S
T
L
A
S
A
S
E
E
D
N
K
S
G
S
H
E
S
A
S
T
S
L
1080
1081
K
P
S
M
G
E
N
S
G
L
T
T
S
T
E
I
E
A
T
T
T
S
P
T
E
A
P
S
P
A
V
S
S
G
T
D
V
T
T
E
P
T
D
T
R
E
Q
P
T
T
L
S
T
T
S
K
T
N
S
E
1140
1141
S
V
A
T
T
Q
A
T
N
E
N
G
G
K
S
P
S
T
D
L
T
S
S
L
T
T
G
T
S
A
S
T
S
A
N
S
E
L
V
T
S
G
S
V
T
G
G
A
V
A
S
A
S
N
D
Q
S
H
S
T
1200
1201
S
V
T
N
S
N
S
I
V
S
N
T
P
Q
T
T
L
S
Q
Q
V
T
S
S
S
P
S
T
N
T
F
I
A
S
T
Y
D
G
S
G
S
I
I
Q
H
S
T
W
L
Y
G
L
I
T
L
L
S
L
F
I
1260
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1008
Peptide:
SNGIVI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q5A8T4
UniProt Name:
ALS1_CANAL
Protein Name:
Agglutinin-like protein 1 (Adhesin 1)
Position:
322-327
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.85
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
26.9
Area of the profile Above Threshold (AGGRESCAN):
2.46
Best Energy Score (PASTA 2.0):
-4.61
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1009 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1009
Peptide:
SNMGGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
305-310
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-43.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1010 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1010
Peptide:
SNNFGA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
12054816
Reference:
J Mol Biol. 2002 May 3;318(3):697-706
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.18
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1011 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
A
D
H
H
L
Q
Q
Q
Q
Q
Q
R
Q
Q
H
Q
Q
Q
Q
H
Q
Q
Q
Q
H
Q
H
Q
H
Q
Q
Q
Q
H
T
I
L
Q
N
V
S
N
T
N
N
I
G
S
D
S
L
A
S
Q
P
F
N
T
60
61
T
T
V
S
S
N
K
D
D
V
M
V
N
S
G
A
R
E
L
P
M
P
L
H
Q
Q
Q
Y
I
Y
P
Y
Y
Q
Y
T
S
N
N
S
N
N
N
N
V
T
A
G
N
N
M
S
A
S
P
I
V
H
N
N
120
121
S
N
N
S
N
N
S
N
I
S
A
S
D
Y
T
V
A
N
N
S
T
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
H
P
N
Q
F
T
A
A
A
N
M
N
S
N
A
A
A
A
A
Y
Y
S
180
181
F
P
T
A
N
M
P
I
P
Q
Q
D
Q
Q
Y
M
F
N
P
A
S
Y
I
S
H
Y
Y
S
A
V
N
S
N
N
N
G
N
N
A
A
N
N
G
S
N
N
S
S
H
S
A
P
A
P
A
P
G
P
P
H
240
241
H
H
H
H
H
S
N
T
H
N
N
L
N
N
G
G
A
V
N
T
N
N
A
P
Q
H
H
P
T
I
I
T
D
Q
F
Q
F
Q
L
Q
Q
N
P
S
P
N
L
N
L
N
I
N
P
A
Q
P
L
H
L
P
300
301
P
G
W
K
I
N
T
M
P
Q
P
R
P
T
T
A
P
N
H
P
P
A
P
V
P
S
S
N
P
V
A
S
N
L
V
P
A
P
S
S
D
H
K
Y
I
H
Q
C
Q
F
C
E
K
S
F
K
R
K
S
W
360
361
L
K
R
H
L
L
S
H
S
Q
Q
R
H
F
L
C
P
W
C
L
S
R
Q
K
R
K
D
N
L
L
Q
H
M
K
L
K
H
T
N
Y
L
L
D
E
L
K
K
N
N
I
I
F
N
Y
N
N
S
S
S
S
420
421
N
N
N
N
D
N
N
N
N
N
N
S
N
S
A
S
G
S
G
G
A
G
A
A
A
A
A
A
T
A
P
E
N
E
D
G
N
G
Y
D
T
N
I
K
T
L
I
N
D
G
V
L
N
K
D
D
V
K
R
V
480
481
L
N
N
L
I
V
S
H
N
K
490
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1011
Peptide:
SNNSNI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P54785
UniProt Name:
MOT3_YEAST
Protein Name:
Transcriptional activator/repressor MOT3
Position:
124-129
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-69.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1012 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1012
Peptide:
SNQGNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
4-9
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-104.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1013 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1013
Peptide:
SNQNNF
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
2OL9
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
170-175
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7. Epub 2007 Apr 29
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-88.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1014 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1014
Peptide:
SNSGAA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
377-382
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-55.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.37
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1015 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
P
G
G
E
Q
T
I
M
E
Q
P
A
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
A
A
V
P
Q
Q
P
L
D
P
L
T
Q
S
T
A
E
T
W
L
S
I
A
S
L
A
E
T
L
G
60
61
D
G
D
R
A
A
M
A
Y
D
A
T
L
Q
F
N
P
S
S
A
K
A
L
T
S
L
A
H
L
Y
R
S
R
D
M
F
Q
R
A
A
E
L
Y
E
R
A
L
L
V
N
P
E
L
S
D
V
W
A
T
L
120
121
G
H
C
Y
L
M
L
D
D
L
Q
R
A
Y
N
A
Y
Q
Q
A
L
Y
H
L
S
N
P
N
V
P
K
L
W
H
G
I
G
I
L
Y
D
R
Y
G
S
L
D
Y
A
E
E
A
F
A
K
V
L
E
L
D
180
181
P
H
F
E
K
A
N
E
I
Y
F
R
L
G
I
I
Y
K
H
Q
G
K
W
S
Q
A
L
E
C
F
R
Y
I
L
P
Q
P
P
A
P
L
Q
E
W
D
I
W
F
Q
L
G
S
V
L
E
S
M
G
E
W
240
241
Q
G
A
K
E
A
Y
E
H
V
L
A
Q
N
Q
H
H
A
K
V
L
Q
Q
L
G
C
L
Y
G
M
S
N
V
Q
F
Y
D
P
Q
K
A
L
D
Y
L
L
K
S
L
E
A
D
P
S
D
A
T
T
W
Y
300
301
H
L
G
R
V
H
M
I
R
T
D
Y
T
A
A
Y
D
A
F
Q
Q
A
V
N
R
D
S
R
N
P
I
F
W
C
S
I
G
V
L
Y
Y
Q
I
S
Q
Y
R
D
A
L
D
A
Y
T
R
A
I
R
L
N
360
361
P
Y
I
S
E
V
W
Y
D
L
G
T
L
Y
E
T
C
N
N
Q
L
S
D
A
L
D
A
Y
K
Q
A
A
R
L
D
V
N
N
V
H
I
R
E
R
L
E
A
L
T
K
Q
L
E
N
P
G
N
I
N
K
420
421
S
N
G
A
P
T
N
A
S
P
A
P
P
P
V
I
L
Q
P
T
L
Q
P
N
D
Q
G
N
P
L
N
T
R
I
S
A
Q
S
A
N
A
T
A
S
M
V
Q
Q
Q
H
P
A
Q
Q
T
P
I
N
S
S
480
481
A
T
M
Y
S
N
G
A
S
P
Q
L
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
H
A
Q
A
540
541
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
L
Q
P
L
P
R
Q
Q
L
Q
Q
K
G
600
601
V
S
V
Q
M
L
N
P
Q
Q
G
Q
P
Y
I
T
Q
P
T
V
I
Q
A
H
Q
L
Q
P
F
S
T
Q
A
M
E
H
P
Q
S
S
Q
L
P
P
Q
Q
Q
Q
L
Q
S
V
Q
H
P
Q
Q
L
Q
G
660
661
Q
P
Q
A
Q
A
P
Q
P
L
I
Q
H
N
V
E
Q
N
V
L
P
Q
K
R
Y
M
E
G
A
I
H
T
L
V
D
A
A
V
S
S
S
T
H
T
E
N
N
T
K
S
P
R
Q
P
T
H
A
I
P
T
720
721
Q
A
P
A
T
G
I
T
N
A
E
P
Q
V
K
K
Q
K
L
N
S
P
N
S
N
I
N
K
L
V
N
T
A
T
S
I
E
E
N
A
K
S
E
V
S
N
Q
S
P
A
V
V
E
S
N
T
N
N
T
S
780
781
Q
E
E
K
P
V
K
A
N
S
I
P
S
V
I
G
A
Q
E
P
P
Q
E
A
S
P
A
E
E
A
T
K
A
A
S
V
S
P
S
T
K
P
L
N
T
E
P
E
S
S
S
V
Q
P
T
V
S
S
E
S
840
841
S
T
T
K
A
N
D
Q
S
T
A
E
T
I
E
L
S
T
A
T
V
P
A
E
A
S
P
V
E
D
E
V
R
Q
H
S
K
E
E
N
G
T
T
E
A
S
A
P
S
T
E
E
A
E
P
A
A
S
R
D
900
901
A
E
K
Q
Q
D
E
T
A
A
T
T
I
T
V
I
K
P
T
L
E
T
M
E
T
V
K
E
E
A
K
M
R
E
E
E
Q
T
S
Q
E
K
S
P
Q
E
N
T
L
P
R
E
N
V
V
R
Q
V
E
E
960
961
D
E
N
Y
D
D
966
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1015
Peptide:
SNTNNT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14922
UniProt Name:
CYC8_YEAST
Protein Name:
Glucose repression mediator protein CYC8
Position:
774-779
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-86.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1016 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1016
Peptide:
SNVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.85
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.1
Area of the profile Above Threshold (AGGRESCAN):
2.56
Best Energy Score (PASTA 2.0):
-5.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1017 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1017
Peptide:
SPVIIE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
53.0
Area of the profile Above Threshold (AGGRESCAN):
3.18
Best Energy Score (PASTA 2.0):
-3.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1018 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
S
Q
A
I
I
H
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1018
Peptide:
SQAIIH
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
MYG_HUMAN
Protein Name:
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.3
Area of the profile Above Threshold (AGGRESCAN):
1.36
Best Energy Score (PASTA 2.0):
-3.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1019 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Y
P
N
W
G
R
Y
G
G
S
S
H
Y
P
P
P
P
V
P
P
P
P
P
V
A
L
P
E
A
S
P
G
P
G
Y
S
S
S
T
T
P
A
A
P
S
S
S
G
F
M
S
F
R
E
Q
H
L
A
Q
60
61
L
Q
Q
L
Q
Q
M
H
Q
K
Q
M
Q
C
V
L
Q
P
H
H
L
P
P
P
P
L
P
P
P
P
V
M
P
G
G
G
Y
G
D
W
Q
P
P
P
P
P
M
P
P
P
P
G
P
A
L
S
Y
Q
K
Q
120
121
Q
Q
Y
K
H
Q
M
L
H
H
Q
R
D
G
P
P
G
L
V
P
M
E
L
E
S
P
P
E
S
P
P
V
P
P
G
S
Y
M
P
P
S
Q
S
Y
M
P
P
P
Q
P
P
P
S
Y
Y
P
P
T
S
S
180
181
Q
P
Y
L
P
P
A
Q
P
S
P
S
Q
S
P
P
S
Q
S
Y
L
A
P
T
P
S
Y
S
S
S
S
S
S
S
Q
S
Y
L
S
H
S
Q
S
Y
L
P
S
S
Q
A
S
P
S
R
P
S
Q
G
H
S
240
241
K
S
Q
L
L
A
P
P
P
P
S
A
P
P
G
N
K
T
T
V
Q
Q
E
P
L
E
S
G
A
K
N
K
S
T
E
Q
Q
Q
A
A
P
E
P
D
P
S
T
M
T
P
Q
E
Q
Q
Q
Y
W
Y
R
Q
300
301
H
L
L
S
L
Q
Q
R
T
K
V
H
L
P
G
H
K
K
G
P
V
V
A
K
D
T
P
E
P
V
K
E
E
V
T
V
P
A
T
S
Q
V
P
E
S
P
S
S
E
E
P
P
L
P
P
P
N
E
E
V
360
361
P
P
P
L
P
P
E
E
P
Q
S
E
D
P
E
E
D
A
R
L
K
Q
L
Q
A
A
A
A
H
W
Q
Q
H
Q
Q
H
R
V
G
F
Q
Y
Q
G
I
M
Q
K
H
T
Q
L
Q
Q
I
L
Q
Q
Y
Q
420
421
Q
I
I
Q
P
P
P
H
I
Q
A
T
T
P
P
P
G
I
P
P
P
G
V
P
Q
G
I
P
P
Q
L
T
A
A
P
V
P
P
A
S
S
S
Q
S
S
Q
V
P
E
K
P
R
P
A
L
L
P
T
P
V
480
481
S
F
G
S
A
P
P
T
T
Y
H
P
P
L
Q
S
A
G
P
S
E
Q
V
N
S
K
A
P
L
S
K
S
A
L
P
Y
S
S
F
S
S
D
Q
G
L
G
E
S
S
A
A
P
S
Q
P
I
T
A
V
K
540
541
D
M
P
V
R
S
G
G
L
L
P
D
P
P
R
S
S
Y
L
E
S
P
R
G
P
R
F
D
G
P
R
R
F
E
D
L
G
S
R
C
E
G
P
R
P
K
G
P
R
F
E
G
N
R
P
D
G
P
R
P
600
601
R
Y
E
G
H
P
A
E
G
T
K
S
K
W
G
M
I
P
R
G
P
A
S
Q
F
Y
I
T
P
S
T
S
L
S
P
R
Q
S
G
P
Q
W
K
G
P
K
P
A
F
G
Q
Q
H
Q
Q
Q
P
K
S
Q
660
661
A
E
P
L
S
G
N
K
E
P
L
A
D
T
S
S
N
Q
Q
K
N
F
K
M
Q
S
A
A
F
S
I
A
A
D
V
K
D
V
K
A
A
Q
S
N
E
N
L
S
D
S
Q
Q
E
P
P
K
S
E
V
S
720
721
E
G
P
V
E
P
S
N
W
D
Q
N
V
Q
S
M
E
T
Q
I
D
K
A
Q
A
V
T
Q
P
V
P
L
A
N
K
P
V
P
A
Q
S
T
F
P
S
K
T
G
G
M
E
G
G
T
A
V
A
T
S
S
780
781
L
T
A
D
N
D
F
K
P
V
G
I
G
L
P
H
S
E
N
N
Q
D
K
G
L
P
R
P
D
N
R
D
N
R
L
E
G
N
R
G
N
S
S
S
Y
R
G
P
G
Q
S
R
M
E
D
T
R
D
K
G
840
841
L
V
N
R
G
R
G
Q
A
I
S
R
G
P
G
L
V
K
Q
E
D
F
R
D
K
M
M
G
R
R
E
D
S
R
E
K
M
N
R
G
E
G
S
R
D
R
G
L
V
R
P
G
S
S
R
E
K
V
P
G
900
901
G
L
Q
G
S
Q
D
R
G
A
A
G
S
R
E
R
G
P
P
R
R
A
G
S
Q
E
R
G
P
L
R
R
A
G
S
R
E
R
I
P
P
R
R
A
G
S
R
E
R
G
P
P
R
G
P
G
S
R
E
R
960
961
G
L
G
R
S
D
F
G
R
D
R
G
P
F
R
P
E
P
G
D
G
G
E
K
M
Y
P
Y
H
R
D
E
P
P
R
A
P
W
N
H
G
E
E
R
G
H
E
E
F
P
L
D
G
R
N
A
P
M
E
R
1020
1021
E
R
L
D
D
W
D
R
E
R
Y
W
R
E
C
E
R
D
Y
Q
D
D
T
L
E
L
Y
N
R
E
D
R
F
S
A
P
P
S
R
S
H
D
G
D
R
R
G
P
W
W
D
D
W
E
R
D
Q
D
M
D
1080
1081
E
D
Y
N
R
E
M
E
R
D
M
D
R
D
V
D
R
I
S
R
P
M
D
M
Y
D
R
S
L
D
N
E
W
D
R
D
Y
G
R
P
L
D
E
Q
E
S
Q
F
R
E
R
D
I
P
S
L
P
P
L
P
1140
1141
P
L
P
P
L
P
P
L
D
R
Y
R
D
D
R
W
R
E
E
R
N
R
E
H
G
Y
D
R
D
F
R
D
R
G
E
L
R
I
R
E
Y
P
E
R
G
D
T
W
R
E
K
R
D
Y
V
P
D
R
M
D
1200
1201
W
E
R
E
R
L
S
D
R
W
Y
P
S
D
V
D
R
H
S
P
M
A
E
H
M
P
S
S
H
H
S
S
E
M
M
G
S
D
A
S
L
D
S
D
Q
G
L
G
G
V
M
V
L
S
Q
R
Q
H
E
I
1260
1261
I
L
K
A
A
Q
E
L
K
M
L
R
E
Q
K
E
Q
L
Q
K
M
K
D
F
G
S
E
P
Q
M
A
D
H
L
P
P
Q
E
S
R
L
Q
N
T
S
S
R
P
G
M
Y
P
P
P
G
S
Y
R
P
P
1320
1321
P
P
M
G
K
P
P
G
S
I
V
R
P
S
A
P
P
A
R
S
S
V
P
V
T
R
P
P
V
P
I
P
P
P
P
P
P
P
P
L
P
P
P
P
P
V
I
K
P
Q
T
S
A
V
E
Q
E
R
W
D
1380
1381
E
D
S
F
Y
G
L
W
D
T
N
D
E
Q
G
L
N
S
E
F
K
S
E
T
A
A
I
P
S
A
P
V
L
P
P
P
P
V
H
S
S
I
P
P
P
G
P
V
P
M
G
M
P
P
M
S
K
P
P
P
1440
1441
V
Q
Q
T
V
D
Y
G
H
G
R
D
I
S
T
N
K
V
E
Q
I
P
Y
G
E
R
I
T
L
R
P
D
P
L
P
E
R
S
T
F
E
T
E
H
A
G
Q
R
D
R
Y
D
R
E
R
D
R
E
P
Y
1500
1501
F
D
R
Q
S
N
V
I
A
D
H
R
D
F
K
R
D
R
E
T
H
R
D
R
D
R
D
R
G
V
I
D
Y
D
R
D
R
F
D
R
E
R
R
P
R
D
D
R
A
Q
S
Y
R
D
K
K
D
H
S
S
1560
1561
S
R
R
G
G
F
D
R
P
S
Y
D
R
K
S
D
R
P
V
Y
E
G
P
S
M
F
G
G
E
R
R
T
Y
P
E
E
R
M
P
L
P
A
P
S
L
S
H
Q
P
P
P
A
P
R
V
E
K
K
P
E
1620
1621
S
K
N
V
D
D
I
L
K
P
P
G
R
E
S
R
P
E
R
I
V
V
I
M
R
G
L
P
G
S
G
K
T
H
V
A
K
L
I
R
D
K
E
V
E
F
G
G
P
A
P
R
V
L
S
L
D
D
Y
F
1680
1681
I
T
E
V
E
K
E
E
K
D
P
D
S
G
K
K
V
K
K
K
V
M
E
Y
E
Y
E
A
E
M
E
E
T
Y
R
T
S
M
F
K
T
F
K
K
T
L
D
D
G
F
F
P
F
I
I
L
D
A
I
N
1740
1741
D
R
V
R
H
F
D
Q
F
W
S
A
A
K
T
K
G
F
E
V
Y
L
A
E
M
S
A
D
N
Q
T
C
G
K
R
N
I
H
G
R
K
L
K
E
I
N
K
M
A
D
H
W
E
T
A
P
R
H
M
M
1800
1801
R
L
D
I
R
S
L
L
Q
D
A
A
I
E
E
V
E
M
E
D
F
D
A
N
I
E
E
Q
K
E
E
K
K
D
A
E
E
E
E
S
E
L
G
Y
I
P
K
S
K
W
E
M
D
T
S
E
A
K
L
D
1860
1861
K
L
D
G
L
R
T
G
T
K
R
K
R
D
W
E
A
I
A
S
R
M
E
D
Y
L
Q
L
P
D
D
Y
D
T
R
A
S
E
P
G
K
K
R
V
R
W
A
D
L
E
E
K
K
D
A
D
R
K
R
A
1920
1921
I
G
F
V
V
G
Q
T
D
W
E
K
I
T
D
E
S
G
H
L
A
E
K
A
L
N
R
T
K
Y
I
1951
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1019
Peptide:
SQFYIT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P49750
UniProt Name:
YLPM1_HUMAN
Protein Name:
YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113)
Position:
623-628
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
43.6
Area of the profile Above Threshold (AGGRESCAN):
2.79
Best Energy Score (PASTA 2.0):
-3.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1020 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1020
Peptide:
SQGMSL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
121-126
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.0
Area of the profile Above Threshold (AGGRESCAN):
0.26
Best Energy Score (PASTA 2.0):
1.07
Aggregate Orientation (PASTA 2.0):
Parallel
