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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 901 to 930 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0901
QQQYNP
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0902
QQSLFQ
6
Amyloid
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0)
Q14103
No
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-0903
QQSYGQ
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0904
QQSYNP
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0905
QQSYSG
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0906
QQYNPD
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0907
QQYNPQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0908
QQYSQN
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0909
QRGFGN
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0910
QSCPSG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
G348C
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0911
QSGFGN
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
G287S
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0912
QSQGMS
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0913
QSSWGM
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0914
QSSYSS
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0915
QSYGQQ
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0916
QSYNPP
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0917
QSYSGY
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0918
QTDARN
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0919
QTEEKK
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
T206K
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0920
QTFLVN
6
Amyloid
Guanine nucleotide-binding protein subunit beta-5 (Gbeta5)
O14775
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0921
QTFNLF
6
Non-amyloid
Interferon alpha-10 (IFN-alpha-10)
P01566
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0922
QTNLYG
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0923
QTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0924
QVGFGN
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0925
QVVHIG
6
Non-amyloid
von Willebrand factor (vWF)
P04275
P1627H
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0926
QVVPIG
6
Non-amyloid
von Willebrand factor (vWF)
P04275
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0927
QWNGKN
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0928
QYFEQF
6
Amyloid
RNA-binding protein Musashi homolog 1 (Musashi-1)
O43347
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0929
QYGGGG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0930
QYGGGN
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0901 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0901
Peptide:
QQQYNP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
70-75
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-68.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.69
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0902 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
Q
Q
S
L
F
Q
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0902
Peptide:
QQSLFQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q14103
UniProt Name:
HNRPD_HUMAN
Protein Name:
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0)
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-14.0
Area of the profile Above Threshold (AGGRESCAN):
0.44
Best Energy Score (PASTA 2.0):
-0.61
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0903 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0903
Peptide:
QQSYGQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
140-145
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-48.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.55
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0904 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0904
Peptide:
QQSYNP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
146-151
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.6
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-50.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.55
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0905 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0905
Peptide:
QQSYSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
35-40
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.38
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0906 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0906
Peptide:
QQYNPD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
61-66
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.6
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-72.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0907 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0907
Peptide:
QQYNPQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
71-76
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-66.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0908 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0908
Peptide:
QQYSQN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
14-19
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.26
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-58.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.14
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0909 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0909
Peptide:
QRGFGN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
94-99
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-42.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.65
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0910 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0910
Peptide:
QSCPSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
G348C
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
346-351
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.29
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0911 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0911
Peptide:
QSGFGN
Length:
6
Classification:
Non-amyloid
Mutation(s):
G287S
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
286-291
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.28
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0912 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0912
Peptide:
QSQGMS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
120-125
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.65
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0913 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0913
Peptide:
QSSWGM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
331-336
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-17.5
Area of the profile Above Threshold (AGGRESCAN):
0.24
Best Energy Score (PASTA 2.0):
-0.09
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0914 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0914
Peptide:
QSSYSS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
52-57
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.8
Area of the profile Above Threshold (AGGRESCAN):
0.02
Best Energy Score (PASTA 2.0):
-0.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0915 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0915
Peptide:
QSYGQQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
141-146
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-50.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.64
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0916 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0916
Peptide:
QSYNPP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
147-152
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.63
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-44.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.87
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0917 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0917
Peptide:
QSYSGY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
36-41
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.5
Area of the profile Above Threshold (AGGRESCAN):
0.46
Best Energy Score (PASTA 2.0):
0.04
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0918 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0918
Peptide:
QTDARN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
60-65
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
16.67
NuAPRpred:
-0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-99.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.45
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0919 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0919
Peptide:
QTEEKK
Length:
6
Classification:
Non-amyloid
Mutation(s):
T206K
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
205-210
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
0.0
NuAPRpred:
-0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-110.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.81
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0920 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
C
D
Q
T
F
L
V
N
V
F
G
S
C
D
K
C
F
K
Q
R
A
L
R
P
V
F
K
K
S
Q
Q
L
S
Y
C
S
T
C
A
E
I
M
A
T
E
G
L
H
E
N
E
T
L
A
S
L
K
S
E
60
61
A
E
S
L
K
G
K
L
E
E
E
R
A
K
L
H
D
V
E
L
H
Q
V
A
E
R
V
E
A
L
G
Q
F
V
M
K
T
R
R
T
L
K
G
H
G
N
K
V
L
C
M
D
W
C
K
D
K
R
R
I
120
121
V
S
S
S
Q
D
G
K
V
I
V
W
D
S
F
T
T
N
K
E
H
A
V
T
M
P
C
T
W
V
M
A
C
A
Y
A
P
S
G
C
A
I
A
C
G
G
L
D
N
K
C
S
V
Y
P
L
T
F
D
K
180
181
N
E
N
M
A
A
K
K
K
S
V
A
M
H
T
N
Y
L
S
A
C
S
F
T
N
S
D
M
Q
I
L
T
A
S
G
D
G
T
C
A
L
W
D
V
E
S
G
Q
L
L
Q
S
F
H
G
H
G
A
D
V
240
241
L
C
L
D
L
A
P
S
E
T
G
N
T
F
V
S
G
G
C
D
K
K
A
M
V
W
D
M
R
S
G
Q
C
V
Q
A
F
E
T
H
E
S
D
I
N
S
V
R
Y
Y
P
S
G
D
A
F
A
S
G
S
300
301
D
D
A
T
C
R
L
Y
D
L
R
A
D
R
E
V
A
I
Y
S
K
E
S
I
I
F
G
A
S
S
V
D
F
S
L
S
G
R
L
L
F
A
G
Y
N
D
Y
T
I
N
V
W
D
V
L
K
G
S
R
V
360
361
S
I
L
F
G
H
E
N
R
V
S
T
L
R
V
S
P
D
G
T
A
F
C
S
G
S
W
D
H
T
L
R
V
W
A
395
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0920
Peptide:
QTFLVN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
O14775
UniProt Name:
GBB5_HUMAN
Protein Name:
Guanine nucleotide-binding protein subunit beta-5 (Gbeta5)
Position:
4-9
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.31
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.4
Area of the profile Above Threshold (AGGRESCAN):
2.45
Best Energy Score (PASTA 2.0):
-3.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0921 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
S
F
S
L
L
M
A
V
L
V
L
S
Y
K
S
I
C
S
L
G
C
D
L
P
Q
T
H
S
L
G
N
R
R
A
L
I
L
L
G
Q
M
G
R
I
S
P
F
S
C
L
K
D
R
H
D
F
R
60
61
I
P
Q
E
E
F
D
G
N
Q
F
Q
K
A
Q
A
I
S
V
L
H
E
M
I
Q
Q
T
F
N
L
F
S
T
E
D
S
S
A
A
W
E
Q
S
L
L
E
K
F
S
T
E
L
Y
Q
Q
L
N
D
L
E
120
121
A
C
V
I
Q
E
V
G
V
E
E
T
P
L
M
N
E
D
S
I
L
A
V
R
K
Y
F
Q
R
I
T
L
Y
L
I
E
R
K
Y
S
P
C
A
W
E
V
V
R
A
E
I
M
R
S
L
S
F
S
T
N
180
181
L
Q
K
R
L
R
R
K
D
189
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0921
Peptide:
QTFNLF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01566
UniProt Name:
IFN10_HUMAN
Protein Name:
Interferon alpha-10 (IFN-alpha-10)
Position:
86-91
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.5
Area of the profile Above Threshold (AGGRESCAN):
1.85
Best Energy Score (PASTA 2.0):
-2.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0922 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0922
Peptide:
QTNLYG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.37
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.8
Area of the profile Above Threshold (AGGRESCAN):
0.13
Best Energy Score (PASTA 2.0):
-1.25
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0923 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0923
Peptide:
QTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.73
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.0
Area of the profile Above Threshold (AGGRESCAN):
2.93
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0924 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0924
Peptide:
QVGFGN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
139-144
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.32
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.9
Area of the profile Above Threshold (AGGRESCAN):
0.47
Best Energy Score (PASTA 2.0):
-0.22
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0925 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0925
Peptide:
QVVHIG
Length:
6
Classification:
Non-amyloid
Mutation(s):
P1627H
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1624-1629
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.77
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
21.0
Area of the profile Above Threshold (AGGRESCAN):
1.62
Best Energy Score (PASTA 2.0):
-5.9
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0926 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0926
Peptide:
QVVPIG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1624-1629
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.0
Area of the profile Above Threshold (AGGRESCAN):
1.38
Best Energy Score (PASTA 2.0):
-1.72
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0927 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0927
Peptide:
QWNGKN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
105-110
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-78.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.23
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0928 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
E
T
D
A
P
Q
P
G
L
A
S
P
D
S
P
H
D
P
C
K
M
F
I
G
G
L
S
W
Q
T
T
Q
E
G
L
R
E
Y
F
G
Q
F
G
E
V
K
E
C
L
V
M
R
D
P
L
T
K
R
S
60
61
R
G
F
G
F
V
T
F
M
D
Q
A
G
V
D
K
V
L
A
Q
S
R
H
E
L
D
S
K
T
I
D
P
K
V
A
F
P
R
R
A
Q
P
K
M
V
T
R
T
K
K
I
F
V
G
G
L
S
V
N
T
120
121
T
V
E
D
V
K
Q
Y
F
E
Q
F
G
K
V
D
D
A
M
L
M
F
D
K
T
T
N
R
H
R
G
F
G
F
V
T
F
E
S
E
D
I
V
E
K
V
C
E
I
H
F
H
E
I
N
N
K
M
V
E
180
181
C
K
K
A
Q
P
K
E
V
M
S
P
T
G
S
A
R
G
R
S
R
V
M
P
Y
G
M
D
A
F
M
L
G
I
G
M
L
G
Y
P
G
F
Q
A
T
T
Y
A
S
R
S
Y
T
G
L
A
P
G
Y
T
240
241
Y
Q
F
P
E
F
R
V
E
R
T
P
L
P
S
A
P
V
L
P
E
L
T
A
I
P
L
T
A
Y
G
P
M
A
A
A
A
A
A
A
A
V
V
R
G
T
G
S
H
P
W
T
M
A
P
P
P
G
S
T
300
301
P
S
R
T
G
G
F
L
G
T
T
S
P
G
P
M
A
E
L
Y
G
A
A
N
Q
D
S
G
V
S
S
Y
I
S
A
A
S
P
A
P
S
T
G
F
G
H
S
L
G
G
P
L
I
A
T
A
F
T
N
G
360
361
Y
H
362
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0928
Peptide:
QYFEQF
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
O43347
UniProt Name:
MSI1H_HUMAN
Protein Name:
RNA-binding protein Musashi homolog 1 (Musashi-1)
Position:
127-132
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.9
Area of the profile Above Threshold (AGGRESCAN):
0.42
Best Energy Score (PASTA 2.0):
-0.62
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0929 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0929
Peptide:
QYGGGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
25-30
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-48.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.06
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0930 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0930
Peptide:
QYGGGN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
49-54
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-56.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.06
Aggregate Orientation (PASTA 2.0):
Antiparallel
