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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 931 to 960 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0931
QYGGNA
6
Amyloid
No
Cell Host Microbe. 2009 Jul 23;6(1):45-53.
19616765
Waltz-DB 2.0, AmyLoad
P-0932
QYGGNN
6
Amyloid
No
Cell Host Microbe. 2009 Jul 23;6(1):45-53.
19616765
Waltz-DB 2.0, AmyLoad
P-0933
QYNNSN
6
Non-amyloid
U6 snRNA-associated Sm-like protein LSm4
P40070
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0934
QYNPDA
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0935
QYNPQG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0936
QYSQNG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0937
RATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38R
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0938
REPTKV
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
K184R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0939
RETWFF
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0940
RGFFYT
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0941
RGFGNS
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0942
RGGFNK
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0943
RGNYKN
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0944
RIGIAQ
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
V149R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0945
RLSNNI
6
Non-amyloid
Serine/threonine-protein kinase KSP1
P38691
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0946
RLVFID
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0947
RMFNII
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0948
RNLTKD
6
Non-amyloid
Ribonuclease (RNase A)
P61823
No
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
20133726
Waltz-DB 2.0, AmyLoad
P-0949
RQFNQT
6
Non-amyloid
Hepatocyte nuclear factor 1-beta (HNF-1-beta)
P35680
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0950
RQIVYK
6
non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623R
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0951
RQNQSG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
Q343R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0952
RQVLIF
6
Amyloid
Protocadherin beta-2 (PCDH-beta-2)
Q9Y5E7
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0953
RTPKIQ
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0954
RTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0955
RVAFFE
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0956
RVFNIM
6
Amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0957
RVNHVT
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0958
RVNNNA
6
Non-amyloid
G protein-coupled receptor GPR1
Q12361
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0959
RYQGYQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0960
SAETKE
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0931 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0931
Peptide:
QYGGNA
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
19616765
Reference:
Cell Host Microbe. 2009 Jul 23;6(1):45-53.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.61
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0932 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0932
Peptide:
QYGGNN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
19616765
Reference:
Cell Host Microbe. 2009 Jul 23;6(1):45-53.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-66.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.61
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0933 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
L
Y
L
L
T
N
A
K
G
Q
Q
M
Q
I
E
L
K
N
G
E
I
I
Q
G
I
L
T
N
V
D
N
W
M
N
L
T
L
S
N
V
T
E
Y
S
E
E
S
A
I
N
S
E
D
N
A
E
S
60
61
S
K
A
V
K
L
N
E
I
Y
I
R
G
T
F
I
K
F
I
K
L
Q
D
N
I
I
D
K
V
K
Q
Q
I
N
S
N
N
N
S
N
S
N
G
P
G
H
K
R
Y
Y
N
N
R
D
S
N
N
N
R
G
120
121
N
Y
N
R
R
N
N
N
N
G
N
S
N
R
R
P
Y
S
Q
N
R
Q
Y
N
N
S
N
S
S
N
I
N
N
S
I
N
S
I
N
S
N
N
Q
N
M
N
N
G
L
G
G
S
V
Q
H
H
F
N
S
S
180
181
S
P
Q
K
V
E
F
187
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0933
Peptide:
QYNNSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P40070
UniProt Name:
LSM4_YEAST
Protein Name:
U6 snRNA-associated Sm-like protein LSm4
Position:
142-147
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.3
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-83.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0934 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0934
Peptide:
QYNPDA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
62-67
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-72.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.37
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0935 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0935
Peptide:
QYNPQG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
72-77
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-69.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.97
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0936 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0936
Peptide:
QYSQNG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
15-20
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-68.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0937 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0937
Peptide:
RATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38R
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
29.2
Area of the profile Above Threshold (AGGRESCAN):
2.42
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0938 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0938
Peptide:
REPTKV
Length:
6
Classification:
Non-amyloid
Mutation(s):
K184R
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
184-189
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
33.33
NuAPRpred:
-0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-55.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.33
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0939 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0939
Peptide:
RETWFF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.2
Area of the profile Above Threshold (AGGRESCAN):
1.99
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0940 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0940
Peptide:
RGFFYT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
46-51
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.4
Area of the profile Above Threshold (AGGRESCAN):
2.93
Best Energy Score (PASTA 2.0):
-2.29
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0941 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0941
Peptide:
RGFGNS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
95-100
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-33.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0942 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0942
Peptide:
RGGFNK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
259-264
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-39.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.8
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0943 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0943
Peptide:
RGNYKN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
98-103
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-65.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.71
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0944 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0944
Peptide:
RIGIAQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
V149R
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
149-154
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.33
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.8
Area of the profile Above Threshold (AGGRESCAN):
0.95
Best Energy Score (PASTA 2.0):
-2.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0945 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
L
D
Y
E
I
Y
K
E
G
G
I
L
N
N
R
Y
Q
K
I
E
D
I
S
E
G
S
Y
G
Y
V
S
L
A
K
D
V
R
E
K
R
L
V
A
V
K
Y
I
F
K
L
E
D
D
G
Q
Y
D
G
60
61
P
Q
D
D
E
N
D
C
D
S
S
D
C
D
D
D
E
D
T
K
V
D
T
D
R
H
E
N
E
N
G
N
A
S
S
N
N
G
S
S
R
E
K
K
H
N
L
Y
K
H
K
K
S
L
I
S
S
K
V
K
120
121
S
R
L
S
N
N
I
C
L
E
A
M
Y
E
V
D
I
Q
T
K
I
G
R
H
Q
N
I
A
A
L
L
D
F
F
D
S
Y
I
I
M
E
Y
C
S
G
G
D
L
Y
E
A
I
K
A
D
A
V
P
K
K
180
181
T
K
S
I
T
H
I
I
T
Q
I
M
D
A
I
E
Y
V
H
N
K
G
I
Y
H
R
D
I
K
P
E
N
I
L
I
S
G
I
D
W
T
I
K
L
T
D
W
G
L
A
T
T
D
K
T
S
M
D
R
N
240
241
V
G
S
E
R
Y
M
S
P
E
L
F
D
S
N
L
D
I
K
E
R
K
E
P
Y
D
C
A
K
V
D
L
W
A
M
G
I
V
F
L
N
I
V
F
H
K
N
P
F
S
I
A
N
Q
S
D
K
S
F
C
300
301
Y
F
A
A
N
R
E
A
L
F
D
V
F
S
T
M
A
Y
D
F
F
Q
V
L
R
Y
S
L
T
I
D
P
A
N
R
D
L
K
M
M
R
T
E
L
Q
N
L
S
E
Y
T
L
D
D
E
Y
Y
N
N
L
360
361
D
E
G
Y
E
E
T
M
I
D
G
L
P
P
Q
P
V
P
P
S
S
A
P
V
S
L
P
T
P
I
S
S
S
N
K
Q
H
M
P
E
F
K
K
D
F
N
F
N
N
V
N
E
R
K
R
S
D
V
S
Q
420
421
N
Q
N
V
A
S
G
F
F
K
K
P
S
T
Q
Q
Q
K
F
F
N
Q
G
Y
N
T
T
L
S
T
H
E
R
A
K
S
A
P
K
F
K
F
K
K
R
N
K
Y
G
R
T
D
N
Q
F
S
K
P
V
N
480
481
I
E
D
R
K
K
S
K
I
L
K
K
S
R
K
P
L
G
I
P
T
P
N
T
H
M
N
N
F
F
H
D
Y
K
A
R
D
E
F
N
T
R
D
F
F
T
P
P
S
V
Q
H
R
Y
M
E
G
F
S
N
540
541
N
N
N
K
Q
Y
R
Q
N
R
N
Y
N
N
N
N
N
N
S
N
N
N
H
G
S
N
Y
N
N
F
N
N
G
N
S
Y
I
K
G
W
N
K
N
F
N
K
Y
R
R
P
S
S
S
S
Y
T
G
K
S
P
600
601
L
S
R
Y
N
M
S
Y
N
H
N
N
N
S
S
I
N
G
Y
A
R
R
G
S
T
T
T
V
Q
H
S
P
G
A
Y
I
P
P
N
A
R
N
H
H
V
S
P
T
N
Q
F
L
R
V
P
Q
S
T
A
P
660
661
D
I
S
T
V
L
G
G
K
P
S
Y
Q
E
H
Y
T
Q
D
S
M
D
S
E
G
D
H
D
S
D
D
V
L
F
T
L
E
E
G
D
H
D
F
V
N
G
M
D
N
L
S
I
N
D
H
L
P
H
T
T
720
721
V
G
S
H
N
E
V
F
V
H
A
S
T
N
H
N
N
N
G
N
N
N
H
I
D
T
N
S
T
T
N
Q
Y
H
R
Q
Y
I
P
P
P
L
T
T
S
L
H
I
N
N
N
N
N
E
S
N
E
L
P
D
780
781
L
L
K
S
P
A
S
S
E
A
H
L
N
L
S
S
G
P
I
D
P
I
L
T
G
N
I
G
N
R
Y
S
H
S
S
D
S
K
E
L
E
Q
E
R
R
L
S
M
E
Q
K
F
K
N
G
V
Y
V
P
P
840
841
H
H
R
K
S
F
N
L
G
T
Q
V
P
P
M
N
M
K
T
S
N
E
A
T
L
S
V
S
H
N
S
V
N
F
G
G
S
Y
N
S
R
R
S
S
A
N
E
S
N
P
L
H
M
N
K
A
L
E
K
L
900
901
S
S
S
P
G
A
K
S
S
F
V
G
F
P
K
P
L
L
P
R
N
H
S
S
T
T
I
A
L
Q
N
E
D
V
F
A
D
S
N
N
D
A
I
I
F
E
D
E
E
Y
E
G
E
S
D
K
M
A
H
G
960
961
K
M
E
G
G
D
N
E
S
S
S
T
S
P
D
E
R
Q
I
F
G
P
Y
E
I
Y
A
Q
T
F
A
G
S
T
H
D
K
K
L
G
A
G
R
K
T
S
I
Q
D
E
M
V
G
S
L
E
Q
Y
K
N
1020
1021
N
W
L
I
L
Q
Q
Q
D
1029
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0945
Peptide:
RLSNNI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P38691
UniProt Name:
KSP1_YEAST
Protein Name:
Serine/threonine-protein kinase KSP1
Position:
122-127
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-43.1
Area of the profile Above Threshold (AGGRESCAN):
0.08
Best Energy Score (PASTA 2.0):
-2.02
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0946 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0946
Peptide:
RLVFID
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
-0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
60.8
Area of the profile Above Threshold (AGGRESCAN):
3.97
Best Energy Score (PASTA 2.0):
-5.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0947 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0947
Peptide:
RMFNII
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.2
Area of the profile Above Threshold (AGGRESCAN):
2.67
Best Energy Score (PASTA 2.0):
-4.99
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0948 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
K
S
L
V
L
L
S
L
L
V
L
V
L
L
L
V
R
V
Q
P
S
L
G
K
E
T
A
A
A
K
F
E
R
Q
H
M
D
S
S
T
S
A
A
S
S
S
N
Y
C
N
Q
M
M
K
S
R
N
60
61
L
T
K
D
R
C
K
P
V
N
T
F
V
H
E
S
L
A
D
V
Q
A
V
C
S
Q
K
N
V
A
C
K
N
G
Q
T
N
C
Y
Q
S
Y
S
T
M
S
I
T
D
C
R
E
T
G
S
S
K
Y
P
N
120
121
C
A
Y
K
T
T
Q
A
N
K
H
I
I
V
A
C
E
G
N
P
Y
V
P
V
H
F
D
A
S
V
150
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0948
Peptide:
RNLTKD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61823
UniProt Name:
RNAS1_BOVIN
Protein Name:
Ribonuclease (RNase A)
Position:
59-64
Literature
PMID:
20133726
Reference:
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.43
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0949 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
S
K
L
T
S
L
Q
Q
E
L
L
S
A
L
L
S
S
G
V
T
K
E
V
L
V
Q
A
L
E
E
L
L
P
S
P
N
F
G
V
K
L
E
T
L
P
L
S
P
G
S
G
A
E
P
D
T
K
P
60
61
V
F
H
T
L
T
N
G
H
A
K
G
R
L
S
G
D
E
G
S
E
D
G
D
D
Y
D
T
P
P
I
L
K
E
L
Q
A
L
N
T
E
E
A
A
E
Q
R
A
E
V
D
R
M
L
S
E
D
P
W
R
120
121
A
A
K
M
I
K
G
Y
M
Q
Q
H
N
I
P
Q
R
E
V
V
D
V
T
G
L
N
Q
S
H
L
S
Q
H
L
N
K
G
T
P
M
K
T
Q
K
R
A
A
L
Y
T
W
Y
V
R
K
Q
R
E
I
L
180
181
R
Q
F
N
Q
T
V
Q
S
S
G
N
M
T
D
K
S
S
Q
D
Q
L
L
F
L
F
P
E
F
S
Q
Q
S
H
G
P
G
Q
S
D
D
A
C
S
E
P
T
N
K
K
M
R
R
N
R
F
K
W
G
P
240
241
A
S
Q
Q
I
L
Y
Q
A
Y
D
R
Q
K
N
P
S
K
E
E
R
E
A
L
V
E
E
C
N
R
A
E
C
L
Q
R
G
V
S
P
S
K
A
H
G
L
G
S
N
L
V
T
E
V
R
V
Y
N
W
F
300
301
A
N
R
R
K
E
E
A
F
R
Q
K
L
A
M
D
A
Y
S
S
N
Q
T
H
S
L
N
P
L
L
S
H
G
S
P
H
H
Q
P
S
S
S
P
P
N
K
L
S
G
V
R
Y
S
Q
Q
G
N
N
E
I
360
361
T
S
S
S
T
I
S
H
H
G
N
S
A
M
V
T
S
Q
S
V
L
Q
Q
V
S
P
A
S
L
D
P
G
H
N
L
L
S
P
D
G
K
M
I
S
V
S
G
G
G
L
P
P
V
S
T
L
T
N
I
H
420
421
S
L
S
H
H
N
P
Q
Q
S
Q
N
L
I
M
T
P
L
S
G
V
M
A
I
A
Q
S
L
N
T
S
Q
A
Q
S
V
P
V
I
N
S
V
A
G
S
L
A
A
L
Q
P
V
Q
F
S
Q
Q
L
H
S
480
481
P
H
Q
Q
P
L
M
Q
Q
S
P
G
S
H
M
A
Q
Q
P
F
M
A
A
V
T
Q
L
Q
N
S
H
M
Y
A
H
K
Q
E
P
P
Q
Y
S
H
T
S
R
F
P
S
A
M
V
V
T
D
T
S
S
I
540
541
S
T
L
T
N
M
S
S
S
K
Q
C
P
L
Q
A
W
557
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0949
Peptide:
RQFNQT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35680
UniProt Name:
HNF1B_HUMAN
Protein Name:
Hepatocyte nuclear factor 1-beta (HNF-1-beta)
Position:
181-186
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-55.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.1
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0950 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0950
Peptide:
RQIVYK
Length:
6
Classification:
non-amyloid
Mutation(s):
V623R
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.6
Area of the profile Above Threshold (AGGRESCAN):
2.01
Best Energy Score (PASTA 2.0):
-3.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0951 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0951
Peptide:
RQNQSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
Q343R
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
343-348
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-106.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.12
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0952 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
E
A
G
E
G
K
E
R
V
P
K
Q
R
Q
V
L
I
F
F
V
L
L
G
I
A
Q
A
S
C
Q
P
R
H
Y
S
V
A
E
E
T
E
S
G
S
F
V
A
N
L
L
K
D
L
G
L
E
I
G
E
60
61
L
A
V
R
G
A
R
V
V
S
K
G
K
K
M
H
L
Q
F
D
R
Q
T
G
D
L
L
L
N
E
K
L
D
R
E
E
L
C
G
P
T
E
P
C
V
L
P
F
Q
V
L
L
E
N
P
L
Q
F
F
Q
120
121
A
E
L
R
I
R
D
V
N
D
H
S
P
V
F
L
D
K
E
I
L
L
K
I
P
E
S
I
T
P
G
T
T
F
L
I
E
R
A
Q
D
L
D
V
G
T
N
S
L
Q
N
Y
T
I
S
P
N
F
H
F
180
181
H
L
N
L
Q
D
S
L
D
G
I
I
L
P
Q
L
V
L
N
R
A
L
D
R
E
E
Q
P
E
I
R
L
T
L
T
A
L
D
G
G
S
P
P
R
S
G
T
A
L
V
R
I
E
V
V
D
I
N
D
N
240
241
V
P
E
F
A
K
L
L
Y
E
V
Q
I
P
E
D
S
P
V
G
S
Q
V
A
I
V
S
A
R
D
L
D
I
G
T
N
G
E
I
S
Y
A
F
S
Q
A
S
E
D
I
R
K
T
F
R
L
S
A
K
S
300
301
G
E
L
L
L
R
Q
K
L
D
F
E
S
I
Q
T
Y
T
V
N
I
Q
A
T
D
G
G
G
L
S
G
T
C
V
V
F
V
Q
V
M
D
L
N
D
N
P
P
E
L
T
M
S
T
L
I
N
Q
I
P
E
360
361
N
L
Q
D
T
L
I
A
V
F
S
V
S
D
P
D
S
G
D
N
G
R
M
V
C
S
I
Q
D
D
L
P
F
F
L
K
P
S
V
E
N
F
Y
T
L
V
I
S
T
A
L
D
R
E
T
R
S
E
Y
N
420
421
I
T
I
T
V
T
D
F
G
T
P
R
L
K
T
E
H
N
I
T
V
L
V
S
D
V
N
D
N
A
P
A
F
T
Q
T
S
Y
T
L
F
V
R
E
N
N
S
P
A
L
H
I
G
S
V
S
A
T
D
R
480
481
D
S
G
T
N
A
Q
V
T
Y
S
L
L
P
P
Q
D
P
H
L
P
L
A
S
L
V
S
I
N
A
D
N
G
H
L
F
A
L
Q
S
L
D
Y
E
A
L
Q
A
F
E
F
R
V
G
A
A
D
R
G
S
540
541
P
A
L
S
S
E
A
L
V
R
V
L
V
L
D
A
N
D
N
S
P
F
V
L
Y
P
L
Q
N
G
S
A
P
C
T
E
L
V
P
R
A
A
E
P
G
Y
L
V
T
K
V
V
A
V
D
G
D
S
G
Q
600
601
N
A
W
L
S
Y
Q
L
L
K
A
T
E
P
G
L
F
G
V
W
A
H
N
G
E
V
R
T
A
R
L
L
R
E
R
D
A
A
K
Q
R
L
V
V
L
V
K
D
N
G
E
P
P
R
S
A
T
A
T
L
660
661
H
V
L
L
V
D
G
F
S
Q
P
Y
L
L
L
P
E
A
A
P
A
Q
A
Q
A
D
L
L
T
V
Y
L
V
V
A
L
A
S
V
S
S
L
F
L
F
S
V
L
L
F
V
A
V
R
L
C
R
R
S
R
720
721
A
A
S
V
G
R
C
S
V
P
E
G
P
F
P
G
Q
M
V
D
V
S
G
T
G
T
L
S
Q
S
Y
Q
Y
E
V
C
L
T
G
G
S
G
T
N
E
F
K
F
L
K
P
I
I
P
N
F
V
A
Q
G
780
781
A
E
R
V
S
E
A
N
P
S
F
R
K
S
F
E
F
T
798
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0952
Peptide:
RQVLIF
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q9Y5E7
UniProt Name:
PCDB2_HUMAN
Protein Name:
Protocadherin beta-2 (PCDH-beta-2)
Position:
14-19
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
54.4
Area of the profile Above Threshold (AGGRESCAN):
3.8
Best Energy Score (PASTA 2.0):
-5.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0953 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0953
Peptide:
RTPKIQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
23-28
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-45.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.2
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0954 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0954
Peptide:
RTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
45.9
Area of the profile Above Threshold (AGGRESCAN):
2.92
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0955 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0955
Peptide:
RVAFFE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
34.4
Area of the profile Above Threshold (AGGRESCAN):
2.24
Best Energy Score (PASTA 2.0):
-3.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0956 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0956
Peptide:
RVFNIM
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.2
Area of the profile Above Threshold (AGGRESCAN):
2.4
Best Energy Score (PASTA 2.0):
-5.02
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0957 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0957
Peptide:
RVNHVT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
101-106
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
0.0
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.2
Area of the profile Above Threshold (AGGRESCAN):
0.16
Best Energy Score (PASTA 2.0):
-3.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0958 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
T
E
G
F
P
P
N
L
N
A
L
K
G
S
S
L
L
E
K
R
V
D
S
L
R
Q
L
N
T
T
T
V
N
Q
L
L
G
L
P
G
M
T
S
T
F
T
A
P
Q
L
L
Q
L
R
I
I
A
I
60
61
T
A
S
A
V
S
L
I
A
G
C
L
G
M
F
F
L
S
K
M
D
K
R
R
K
V
F
R
H
D
L
I
A
F
L
I
I
C
D
F
L
K
A
F
I
L
M
I
Y
P
M
I
I
L
I
N
N
S
V
Y
120
121
A
T
P
A
F
F
N
T
L
G
W
F
T
A
F
A
I
E
G
A
D
M
A
I
M
I
F
A
I
H
F
A
I
L
I
F
K
P
N
W
K
W
R
N
K
R
S
G
N
M
E
G
G
L
Y
K
K
R
S
Y
180
181
I
W
P
I
T
A
L
V
P
A
I
L
A
S
L
A
F
I
N
Y
N
K
L
N
D
D
S
D
T
T
I
I
L
D
N
N
N
Y
N
F
P
D
S
P
R
Q
G
G
Y
K
P
W
S
A
W
C
Y
L
P
P
240
241
K
P
Y
W
Y
K
I
V
L
S
W
G
P
R
Y
F
I
I
I
F
I
F
A
V
Y
L
S
I
Y
I
F
I
T
S
E
S
K
R
I
K
A
Q
I
G
D
F
N
H
N
V
L
E
E
E
K
E
K
K
K
L
300
301
F
G
L
G
H
W
G
K
A
K
W
Y
F
R
S
Y
F
K
L
P
L
L
H
L
L
R
N
L
K
N
F
F
T
I
S
F
I
D
P
N
E
E
T
D
D
S
G
S
S
N
G
T
F
N
F
G
E
S
S
N
360
361
E
I
P
T
L
F
R
K
T
N
T
G
S
D
E
N
V
S
A
S
G
G
V
R
L
L
D
Y
N
S
A
K
P
L
D
M
S
K
Y
A
M
S
E
Q
P
D
L
E
R
N
N
P
F
D
C
E
N
D
I
T
420
421
L
N
P
S
E
L
V
S
K
Q
K
E
H
K
V
T
F
S
V
E
N
E
G
L
D
T
R
K
S
S
M
L
G
H
Q
T
F
S
C
Q
N
S
L
E
S
P
L
A
M
Y
D
N
K
N
D
N
S
D
I
T
480
481
S
N
I
K
E
K
G
G
I
I
N
N
N
S
N
N
D
D
D
D
N
N
N
N
N
D
N
D
N
D
N
N
N
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
540
541
N
N
N
N
S
N
N
I
K
N
N
V
D
N
N
N
T
N
P
A
D
N
I
P
T
L
S
N
E
A
F
T
P
S
Q
Q
F
S
Q
E
R
V
N
N
N
A
D
R
C
E
N
S
S
F
T
N
V
Q
Q
H
600
601
F
Q
A
Q
T
Y
K
Q
M
K
K
R
R
A
Q
I
Q
K
N
L
R
A
I
F
I
Y
P
L
S
Y
I
G
I
W
L
F
P
I
I
A
D
A
L
Q
Y
N
H
E
I
K
H
G
P
T
M
W
V
T
Y
I
660
661
D
T
C
V
R
P
L
S
C
L
V
D
V
I
V
Y
L
F
K
E
K
P
W
N
Y
S
W
A
K
T
E
S
K
Y
L
I
E
K
Y
I
L
K
G
E
L
G
E
K
E
I
L
K
F
C
H
S
N
W
G
K
720
721
R
G
W
Y
Y
R
G
K
W
K
K
R
K
C
W
K
Y
S
T
N
P
L
K
R
I
L
W
F
V
E
R
F
F
K
Q
L
F
E
L
K
L
H
F
S
F
Y
D
N
C
D
D
F
E
Y
W
E
N
Y
Y
S
780
781
A
K
D
S
N
D
N
K
R
T
E
S
D
E
T
K
T
N
S
S
D
R
S
L
P
S
N
S
L
E
L
Q
A
M
L
N
N
I
T
A
E
E
V
E
V
P
L
F
W
R
I
I
H
H
I
P
M
L
G
G
840
841
I
D
L
D
E
L
N
R
L
L
K
I
R
Y
N
N
D
H
F
S
L
P
G
L
K
F
A
L
N
Q
N
K
S
H
D
K
H
Q
D
V
S
T
N
S
M
V
K
S
S
F
F
S
S
N
I
V
T
N
D
D
900
901
E
N
S
I
E
E
D
K
N
L
R
Y
S
D
A
S
A
S
E
N
Y
L
V
K
P
T
I
P
G
T
T
P
D
P
I
I
E
A
Q
N
D
N
D
S
S
D
S
S
G
I
D
L
I
A
F
L
R
N
G
P
960
961
L
961
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0958
Peptide:
RVNNNA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12361
UniProt Name:
GPR1_YEAST
Protein Name:
G protein-coupled receptor GPR1
Position:
581-586
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-79.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.94
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0959 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0959
Peptide:
RYQGYQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
28-33
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-47.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.57
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0960 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0960
Peptide:
SAETKE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
176-181
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-79.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
