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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1171 to 1200 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1171
TFSINP
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
A315T
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1172
TFWEIS
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1173
TGELAT
6
amyloid
Zona pellucida sperm-binding protein 2
Q05996
C372A
FEBS Lett. 2016 Mar;590(5):619-30.
26879157
Waltz-DB 2.0
P-1174
TGVTII
6
Non-amyloid
Cell wall adhesin EAP1
G1UBC2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1175
TGVVVV
6
Non-amyloid
Caf1 hyphal wall protein 1
B2L5Z5
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1176
TIITLE
6
amyloid
Cellular tumor antigen p53
P04637
No
Cancer Cell. 2016 Jan 11;29(1):90-103.
26748848
Waltz-DB 2.0
P-1177
TIITVT
6
Amyloid
Cell wall adhesin EAP1
G1UBC2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1178
TITQHG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1179
TKEPTR
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
K188R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1180
TKKVDT
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
G162D
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1181
TKPAES
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1182
TKVEEP
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1183
TLDQWN
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1184
TLKLVS
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1185
TLKNYI
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1186
TNELYM
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1187
TNNNTN
6
Non-amyloid
SWI/SNF chromatin-remodeling complex subunit SWI1
P09547
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1188
TQHGGG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1189
TQIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623T
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1190
TQRGFG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1191
TQVGFG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1192
TREPTK
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
K184R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1193
TRNNTV
6
Non-amyloid
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Q12221
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1194
TTGVTI
6
Non-amyloid
Cell wall adhesin EAP1
G1UBC2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1195
TTGVVV
6
Non-amyloid
Caf1 hyphal wall protein 1
B2L5Z5
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1196
TTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1197
TTVVST
6
Non-amyloid
Flocculin
E9P9G2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1198
TTVVTT
6
Non-amyloid
Flocculin
E9P9G2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1199
TVFHIG
6
Non-amyloid
von Willebrand factor (vWF)
P04275
P1824H
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1200
TVFPIG
6
Non-amyloid
von Willebrand factor (vWF)
P04275
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-1171 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1171
Peptide:
TFSINP
Length:
6
Classification:
Non-amyloid
Mutation(s):
A315T
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
315-320
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.6
Area of the profile Above Threshold (AGGRESCAN):
1.53
Best Energy Score (PASTA 2.0):
-2.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1172 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1172
Peptide:
TFWEIS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
17.6
Area of the profile Above Threshold (AGGRESCAN):
1.3
Best Energy Score (PASTA 2.0):
-1.25
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1173 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
C
R
Q
R
G
G
S
W
S
P
S
G
W
F
N
A
G
W
S
T
Y
R
S
I
S
L
F
F
A
L
V
T
S
G
N
S
I
D
V
S
Q
L
V
N
P
A
F
P
G
T
V
T
C
D
E
R
E
I
60
61
T
V
E
F
P
S
S
P
G
T
K
K
W
H
A
S
V
V
D
P
L
G
L
D
M
P
N
C
T
Y
I
L
D
P
E
K
L
T
L
R
A
T
Y
D
N
C
T
R
R
V
H
G
G
H
Q
M
T
I
R
V
120
121
M
N
N
S
A
A
L
R
H
G
A
V
M
Y
Q
F
F
C
P
A
M
Q
V
E
E
T
Q
G
L
S
A
S
T
I
C
Q
K
D
F
M
S
F
S
L
P
R
V
F
S
G
L
A
D
D
S
K
G
T
K
V
180
181
Q
M
G
W
S
I
E
V
G
D
G
A
R
A
K
T
L
T
L
P
E
A
M
K
E
G
F
S
L
L
I
D
N
H
R
M
T
F
H
V
P
F
N
A
T
G
V
T
H
Y
V
Q
G
N
S
H
L
Y
M
V
240
241
S
L
K
L
T
F
I
S
P
G
Q
K
V
I
F
S
S
Q
A
I
C
A
P
D
P
V
T
C
N
A
T
H
M
T
L
T
I
P
E
F
P
G
K
L
K
S
V
S
F
E
N
Q
N
I
D
V
S
Q
L
H
300
301
D
N
G
I
D
L
E
A
T
N
G
M
K
L
H
F
S
K
T
L
L
K
T
K
L
S
E
K
C
L
L
H
Q
F
Y
L
A
S
L
K
L
T
F
L
L
R
P
E
T
V
S
M
V
I
Y
P
E
C
L
C
360
361
E
S
P
V
S
I
V
T
G
E
L
C
T
Q
D
G
F
M
D
V
E
V
Y
S
Y
Q
T
Q
P
A
L
D
L
G
T
L
R
V
G
N
S
S
C
Q
P
V
F
E
A
Q
S
Q
G
L
V
R
F
H
I
P
420
421
L
N
G
C
G
T
R
Y
K
F
E
D
D
K
V
V
Y
E
N
E
I
H
A
L
W
T
D
F
P
P
S
K
I
S
R
D
S
E
F
R
M
T
V
K
C
S
Y
S
R
N
D
M
L
L
N
I
N
V
E
S
480
481
L
T
P
P
V
A
S
V
K
L
G
P
F
T
L
I
L
Q
S
Y
P
D
N
S
Y
Q
Q
P
Y
G
E
N
E
Y
P
L
V
R
F
L
R
Q
P
I
Y
M
E
V
R
V
L
N
R
D
D
P
N
I
K
L
540
541
V
L
D
D
C
W
A
T
S
T
M
D
P
D
S
F
P
Q
W
N
V
V
V
D
G
C
A
Y
D
L
D
N
Y
Q
T
T
F
H
P
V
G
S
S
V
T
H
P
D
H
Y
Q
R
F
D
M
K
A
F
A
F
600
601
V
S
E
A
H
V
L
S
S
L
V
Y
F
H
C
S
A
L
I
C
N
R
L
S
P
D
S
P
L
C
S
V
T
C
P
V
S
S
R
H
R
R
A
T
G
A
T
E
A
E
K
M
T
V
S
L
P
G
P
I
660
661
L
L
L
S
D
D
S
S
F
R
G
V
G
S
S
D
L
K
A
S
G
S
S
G
E
K
S
R
S
E
T
G
E
E
V
G
S
R
G
A
M
D
T
K
G
H
K
T
A
G
D
V
G
S
K
A
V
A
A
V
720
721
A
A
F
A
G
V
V
A
T
L
G
F
I
Y
Y
L
Y
E
K
R
T
V
S
N
H
745
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1173
Peptide:
TGELAT
Length:
6
Classification:
amyloid
Mutation(s):
C372A
Structure(s):
No structures
Protein Information
UniProt ID:
Q05996
UniProt Name:
ZP2_HUMAN
Protein Name:
Zona pellucida sperm-binding protein 2
Position:
368-373
Literature
PMID:
26879157
Reference:
FEBS Lett. 2016 Mar;590(5):619-30.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-29.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.55
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1174 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
S
Q
I
L
P
L
A
G
A
I
S
V
A
S
G
F
W
I
P
D
F
S
N
K
Q
N
S
N
S
Y
P
G
Q
Y
K
G
K
G
G
Y
Q
D
D
C
G
D
D
Y
K
K
G
Y
K
S
K
T
Y
60
61
S
K
V
K
P
I
T
S
T
D
C
T
T
P
I
Q
P
T
G
T
T
T
G
Y
T
K
D
V
V
E
S
T
S
Y
T
T
D
T
A
Y
T
T
T
V
I
T
V
T
K
C
D
G
G
S
C
S
H
T
A
V
120
121
T
T
G
V
T
I
I
T
V
T
T
N
D
V
I
T
E
Y
T
T
Y
C
P
L
T
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
180
181
E
S
T
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
240
241
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
A
S
T
E
T
A
S
S
T
P
V
E
S
T
V
I
V
P
S
T
T
V
I
T
V
S
S
C
Y
E
D
K
C
S
V
S
S
V
T
T
G
V
V
T
I
300
301
S
S
E
E
T
I
Y
T
T
Y
C
P
I
T
S
S
I
T
I
P
V
P
N
T
S
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
360
361
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
420
421
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
A
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
480
481
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
S
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
G
T
E
A
T
P
V
T
T
Q
P
540
541
V
S
V
L
S
T
S
Q
V
V
T
A
S
G
E
F
S
T
V
T
A
H
S
T
S
I
V
A
S
C
P
E
G
G
C
V
P
E
G
Q
Q
T
E
T
S
P
S
V
P
T
N
G
P
E
V
E
A
S
S
S
600
601
V
L
S
I
P
V
S
S
V
T
T
S
T
I
A
S
S
S
E
T
S
V
P
P
A
Q
V
S
T
F
E
G
S
G
S
A
L
K
K
P
Y
Y
G
L
A
V
A
A
L
V
Y
F
M
653
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1174
Peptide:
TGVTII
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
G1UBC2
UniProt Name:
G1UBC2_CANAL
Protein Name:
Cell wall adhesin EAP1
Position:
122-127
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.77
Tango:
1.15
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
44.4
Area of the profile Above Threshold (AGGRESCAN):
3.1
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1175 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
L
S
T
A
Q
L
I
A
I
A
Y
Y
M
L
S
I
G
A
T
V
P
Q
V
D
G
Q
G
E
T
E
E
A
L
I
Q
K
R
S
Y
D
Y
Y
Q
E
P
C
D
D
Y
P
Q
Q
Q
Q
Q
E
E
P
60
61
C
D
Y
P
Q
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
120
121
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
Q
P
D
D
N
P
P
I
P
N
I
P
T
D
W
I
P
N
I
P
T
D
W
I
P
D
I
P
E
K
P
180
181
T
T
P
A
T
T
P
N
I
P
A
T
T
T
T
S
E
S
S
S
S
S
S
S
S
S
S
T
T
P
K
T
S
A
S
T
T
P
E
S
S
V
P
A
T
T
P
N
T
S
V
P
T
T
S
S
E
S
T
T
240
241
P
A
T
S
P
E
S
S
V
P
V
T
S
G
S
S
I
L
A
T
T
S
E
S
S
S
A
P
A
T
T
P
N
T
S
V
P
T
T
T
T
E
T
K
S
S
S
T
P
L
T
T
T
T
E
H
D
T
T
V
300
301
V
T
V
T
S
C
S
N
S
V
C
T
E
S
E
V
T
T
G
V
I
V
I
T
S
K
D
T
I
Y
T
T
Y
C
P
L
T
E
T
T
P
V
S
T
A
P
A
T
E
T
P
T
G
T
V
S
T
S
T
E
360
361
Q
S
T
T
V
I
T
V
T
S
C
S
E
S
S
C
T
E
S
E
V
T
T
G
V
V
V
V
T
S
E
E
T
V
Y
T
T
F
C
P
L
T
E
N
T
P
G
T
D
S
T
P
E
A
S
I
P
P
M
E
420
421
T
I
P
A
G
S
E
P
S
M
P
A
G
E
T
S
P
A
V
P
K
S
D
V
P
A
T
E
S
A
P
A
P
G
M
T
P
A
G
T
E
T
K
P
A
A
P
K
S
S
A
P
A
T
E
P
S
P
V
A
480
481
P
G
T
E
S
A
P
A
G
S
S
G
A
I
T
I
P
E
S
S
A
V
V
S
T
T
E
G
A
I
P
T
T
L
E
S
V
P
L
M
Q
P
S
A
N
Y
S
S
V
A
P
I
S
T
F
E
G
A
G
N
540
541
N
M
R
L
T
F
G
A
A
I
I
G
I
A
A
F
L
I
558
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1175
Peptide:
TGVVVV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B2L5Z5
UniProt Name:
B2L5Z5_9ASCO
Protein Name:
Caf1 hyphal wall protein 1
Position:
383-388
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.96
Tango:
24.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
74.2
Area of the profile Above Threshold (AGGRESCAN):
4.67
Best Energy Score (PASTA 2.0):
-8.02
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1176 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
E
E
P
Q
S
D
P
S
V
E
P
P
L
S
Q
E
T
F
S
D
L
W
K
L
L
P
E
N
N
V
L
S
P
L
P
S
Q
A
M
D
D
L
M
L
S
P
D
D
I
E
Q
W
F
T
E
D
P
G
P
60
61
D
E
A
P
R
M
P
E
A
A
P
P
V
A
P
A
P
A
A
P
T
P
A
A
P
A
P
A
P
S
W
P
L
S
S
S
V
P
S
Q
K
T
Y
Q
G
S
Y
G
F
R
L
G
F
L
H
S
G
T
A
K
120
121
S
V
T
C
T
Y
S
P
A
L
N
K
M
F
C
Q
L
A
K
T
C
P
V
Q
L
W
V
D
S
T
P
P
P
G
T
R
V
R
A
M
A
I
Y
K
Q
S
Q
H
M
T
E
V
V
R
R
C
P
H
H
E
180
181
R
C
S
D
S
D
G
L
A
P
P
Q
H
L
I
R
V
E
G
N
L
R
V
E
Y
L
D
D
R
N
T
F
R
H
S
V
V
V
P
Y
E
P
P
E
V
G
S
D
C
T
T
I
H
Y
N
Y
M
C
N
S
240
241
S
C
M
G
G
M
N
R
R
P
I
L
T
I
I
T
L
E
D
S
S
G
N
L
L
G
R
N
S
F
E
V
R
V
C
A
C
P
G
R
D
R
R
T
E
E
E
N
L
R
K
K
G
E
P
H
H
E
L
P
300
301
P
G
S
T
K
R
A
L
P
N
N
T
S
S
S
P
Q
P
K
K
K
P
L
D
G
E
Y
F
T
L
Q
I
R
G
R
E
R
F
E
M
F
R
E
L
N
E
A
L
E
L
K
D
A
Q
A
G
K
E
P
G
360
361
G
S
R
A
H
S
S
H
L
K
S
K
K
G
Q
S
T
S
R
H
K
K
L
M
F
K
T
E
G
P
D
S
D
393
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1176
Peptide:
TIITLE
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04637
UniProt Name:
P53_HUMAN
Protein Name:
Cellular tumor antigen p53
Position:
253-258
Literature
PMID:
26748848
Reference:
Cancer Cell. 2016 Jan 11;29(1):90-103.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.66
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
42.2
Area of the profile Above Threshold (AGGRESCAN):
2.83
Best Energy Score (PASTA 2.0):
-4.86
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1177 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
S
Q
I
L
P
L
A
G
A
I
S
V
A
S
G
F
W
I
P
D
F
S
N
K
Q
N
S
N
S
Y
P
G
Q
Y
K
G
K
G
G
Y
Q
D
D
C
G
D
D
Y
K
K
G
Y
K
S
K
T
Y
60
61
S
K
V
K
P
I
T
S
T
D
C
T
T
P
I
Q
P
T
G
T
T
T
G
Y
T
K
D
V
V
E
S
T
S
Y
T
T
D
T
A
Y
T
T
T
V
I
T
V
T
K
C
D
G
G
S
C
S
H
T
A
V
120
121
T
T
G
V
T
I
I
T
V
T
T
N
D
V
I
T
E
Y
T
T
Y
C
P
L
T
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
180
181
E
S
T
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
240
241
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
A
S
T
E
T
A
S
S
T
P
V
E
S
T
V
I
V
P
S
T
T
V
I
T
V
S
S
C
Y
E
D
K
C
S
V
S
S
V
T
T
G
V
V
T
I
300
301
S
S
E
E
T
I
Y
T
T
Y
C
P
I
T
S
S
I
T
I
P
V
P
N
T
S
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
360
361
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
420
421
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
A
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
480
481
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
S
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
G
T
E
A
T
P
V
T
T
Q
P
540
541
V
S
V
L
S
T
S
Q
V
V
T
A
S
G
E
F
S
T
V
T
A
H
S
T
S
I
V
A
S
C
P
E
G
G
C
V
P
E
G
Q
Q
T
E
T
S
P
S
V
P
T
N
G
P
E
V
E
A
S
S
S
600
601
V
L
S
I
P
V
S
S
V
T
T
S
T
I
A
S
S
S
E
T
S
V
P
P
A
Q
V
S
T
F
E
G
S
G
S
A
L
K
K
P
Y
Y
G
L
A
V
A
A
L
V
Y
F
M
653
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1177
Peptide:
TIITVT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
G1UBC2
UniProt Name:
G1UBC2_CANAL
Protein Name:
Cell wall adhesin EAP1
Position:
125-130
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.74
Tango:
7.64
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
57.6
Area of the profile Above Threshold (AGGRESCAN):
3.75
Best Energy Score (PASTA 2.0):
-6.19
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1178 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1178
Peptide:
TITQHG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
69-74
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-42.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.71
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1179 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1179
Peptide:
TKEPTR
Length:
6
Classification:
Non-amyloid
Mutation(s):
K188R
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
183-188
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.63
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-81.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1180 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1180
Peptide:
TKKVDT
Length:
6
Classification:
Non-amyloid
Mutation(s):
G162D
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
158-163
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.38
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-44.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1181 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1181
Peptide:
TKPAES
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
163-168
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.82
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1182 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1182
Peptide:
TKVEEP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
187-192
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
33.33
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-50.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1183 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1183
Peptide:
TLDQWN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
102-107
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.41
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.62
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1184 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1184
Peptide:
TLKLVS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
143-148
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
26.0
Area of the profile Above Threshold (AGGRESCAN):
1.7
Best Energy Score (PASTA 2.0):
-2.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1185 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1185
Peptide:
TLKNYI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.2
Area of the profile Above Threshold (AGGRESCAN):
0.5
Best Energy Score (PASTA 2.0):
-1.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1186 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1186
Peptide:
TNELYM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.1
Area of the profile Above Threshold (AGGRESCAN):
0.59
Best Energy Score (PASTA 2.0):
0.53
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1187 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
F
F
N
L
N
N
N
N
N
N
N
N
T
T
T
T
T
T
T
T
N
N
N
N
T
N
N
N
N
T
N
N
N
N
N
P
A
N
N
T
N
N
N
N
S
T
G
H
S
S
N
T
N
N
N
T
N
N
60
61
N
N
T
N
T
G
A
S
G
V
D
D
F
Q
N
F
F
D
P
K
P
F
D
Q
N
L
D
S
N
N
N
N
S
N
S
N
N
N
D
N
N
N
S
N
T
V
A
S
S
T
N
F
T
S
P
T
A
V
V
N
120
121
N
A
A
P
A
N
V
T
G
G
K
A
A
N
F
I
Q
N
Q
S
P
Q
F
N
S
P
Y
D
S
N
N
S
N
T
N
L
N
S
L
S
P
Q
A
I
L
A
K
N
S
I
I
D
S
S
N
L
P
L
Q
A
180
181
Q
Q
Q
L
Y
G
G
N
N
N
N
N
S
T
G
I
A
N
D
N
V
I
T
P
H
F
I
T
N
V
Q
S
I
S
Q
N
S
S
S
S
T
P
N
T
N
S
N
S
T
P
N
A
N
Q
Q
F
L
P
F
N
240
241
N
S
A
S
N
N
G
N
L
T
S
N
Q
L
I
S
N
Y
A
A
S
N
S
M
D
R
S
S
S
A
S
N
E
F
V
P
N
T
S
D
N
N
N
N
S
N
N
H
N
M
R
N
N
S
N
N
K
T
S
N
300
301
N
N
N
V
T
A
V
P
A
A
T
P
A
N
T
N
N
S
T
S
N
A
N
T
V
F
S
E
R
A
A
M
F
A
A
L
Q
Q
K
Q
Q
Q
R
F
Q
A
L
Q
Q
Q
Q
Q
Q
Q
Q
N
Q
Q
Q
Q
360
361
N
Q
Q
P
Q
Q
Q
Q
Q
Q
Q
Q
N
P
K
F
L
Q
S
Q
R
Q
Q
Q
Q
R
S
I
L
Q
S
L
N
P
A
L
Q
E
K
I
S
T
E
L
N
N
K
Q
Y
E
L
F
M
K
S
L
I
E
N
C
420
421
K
K
R
N
M
P
L
Q
S
I
P
E
I
G
N
R
K
I
N
L
F
Y
L
Y
M
L
V
Q
K
F
G
G
A
D
Q
V
T
R
T
Q
Q
W
S
M
V
A
Q
R
L
Q
I
S
D
Y
Q
Q
L
E
S
I
480
481
Y
F
R
I
L
L
P
Y
E
R
H
M
I
S
Q
E
G
I
K
E
T
Q
A
K
R
I
F
L
Q
Q
F
L
Q
E
L
L
K
K
V
Q
Q
Q
Q
Q
A
A
A
L
A
N
A
N
N
N
I
N
S
A
S
S
540
541
A
P
T
P
A
A
P
G
A
S
V
P
A
T
A
A
P
G
T
E
A
G
I
V
P
V
S
A
N
T
P
K
S
L
N
S
N
I
N
I
N
V
N
N
N
N
I
G
Q
Q
Q
V
K
K
P
R
K
Q
R
V
600
601
K
K
K
T
K
K
E
L
E
L
E
R
K
E
R
E
D
F
Q
K
R
Q
Q
K
L
L
E
D
Q
Q
R
Q
Q
K
L
L
L
E
T
K
L
R
Q
Q
Y
E
I
E
L
K
K
L
P
K
V
Y
K
R
S
I
660
661
V
R
N
Y
K
P
L
I
N
R
L
K
H
Y
N
G
Y
D
I
N
Y
I
S
K
I
G
E
K
I
D
S
N
K
P
I
F
L
F
A
P
E
L
G
A
I
N
L
H
A
L
S
M
S
L
Q
S
K
N
L
G
720
721
E
I
N
T
A
L
N
T
L
L
V
T
S
A
D
S
N
L
K
I
S
L
V
K
Y
P
E
L
L
D
S
L
A
I
L
G
M
N
L
L
S
N
L
S
Q
N
V
V
P
Y
H
R
N
T
S
D
Y
Y
Y
E
780
781
D
A
G
S
N
Q
Y
Y
V
T
Q
H
D
K
M
V
D
K
I
F
E
K
V
N
N
N
A
T
L
T
P
N
D
S
N
D
E
K
V
T
I
L
V
D
S
L
T
G
N
Q
L
P
T
P
T
P
T
E
M
E
840
841
P
D
L
D
T
E
C
F
I
S
M
Q
S
T
S
P
A
V
K
Q
W
D
L
L
P
E
P
I
R
F
L
P
N
Q
F
P
L
K
I
H
R
T
P
Y
L
T
S
L
K
K
I
K
D
E
I
D
D
P
F
T
900
901
K
I
N
T
R
G
A
E
D
P
K
V
L
I
N
D
Q
L
S
T
I
S
M
I
L
R
N
I
S
F
S
D
N
N
S
R
I
M
S
R
N
F
Y
L
K
R
F
I
S
D
L
L
W
L
V
L
I
H
P
E
960
961
N
F
T
C
N
R
K
I
L
N
F
K
K
D
L
V
I
V
L
S
N
I
S
H
L
L
E
I
A
S
S
I
D
C
L
L
I
L
I
L
V
I
S
F
G
Q
P
K
L
N
P
M
A
S
S
S
S
F
G
S
1020
1021
E
S
L
T
F
N
E
F
Q
L
Q
W
G
K
Y
Q
T
F
G
V
D
I
L
A
K
L
F
S
L
E
K
P
N
L
N
Y
F
K
S
I
L
L
N
K
N
T
G
N
N
L
Y
D
R
N
S
N
N
N
H
K
1080
1081
D
K
K
L
L
R
R
L
L
N
L
Y
N
D
N
N
K
N
N
N
N
R
H
N
L
L
N
D
V
V
S
F
L
F
S
A
I
P
L
Q
Q
V
L
S
Q
S
A
D
P
S
L
L
I
D
Q
F
S
P
V
I
1140
1141
S
Q
S
L
T
S
I
L
V
I
V
Q
K
I
L
P
L
S
N
E
V
F
E
I
S
E
N
N
S
D
S
N
S
N
N
N
G
N
K
D
S
S
F
N
F
N
K
N
L
P
F
V
W
L
S
S
E
E
N
I
1200
1201
G
S
G
L
L
K
L
S
E
I
I
L
N
I
N
N
S
T
S
K
N
T
L
L
Q
Q
Q
N
Y
S
K
V
L
L
P
S
I
N
I
S
C
V
Q
L
I
K
C
L
V
E
K
S
I
C
F
E
N
C
L
N
1260
1261
N
D
P
E
I
L
K
K
I
A
S
I
P
N
L
F
P
T
D
L
E
I
F
Q
L
F
T
N
P
S
V
D
I
Q
I
I
N
Q
Y
Q
L
L
Y
N
L
K
N
D
I
L
T
N
L
E
1314
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1187
Peptide:
TNNNTN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09547
UniProt Name:
SWI1_YEAST
Protein Name:
SWI/SNF chromatin-remodeling complex subunit SWI1
Position:
54-59
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-104.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.1
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1188 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1188
Peptide:
TQHGGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
71-76
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-79.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.8
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1189 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1189
Peptide:
TQIVYK
Length:
6
Classification:
amyloid
Mutation(s):
V623T
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.04
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.4
Area of the profile Above Threshold (AGGRESCAN):
2.47
Best Energy Score (PASTA 2.0):
-3.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1190 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1190
Peptide:
TQRGFG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
93-98
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-53.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.57
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1191 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1191
Peptide:
TQVGFG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
138-143
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.2
Area of the profile Above Threshold (AGGRESCAN):
1.05
Best Energy Score (PASTA 2.0):
-0.22
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1192 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1192
Peptide:
TREPTK
Length:
6
Classification:
Non-amyloid
Mutation(s):
K184R
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
183-188
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.63
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-82.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1193 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
N
K
R
L
Y
N
G
N
L
S
N
I
P
E
V
I
D
P
G
I
T
I
P
I
Y
E
E
D
I
R
N
D
T
R
M
N
T
N
A
R
S
V
R
V
S
D
K
R
G
R
S
S
S
T
S
P
Q
K
60
61
I
G
S
Y
R
T
R
A
G
R
F
S
D
T
L
T
N
L
L
P
S
I
S
A
K
L
H
H
S
K
K
S
T
P
V
V
V
V
P
P
T
S
S
T
P
D
S
L
N
S
T
T
Y
A
P
R
V
S
S
D
120
121
S
F
T
V
A
T
P
L
S
L
Q
S
T
T
T
R
T
R
T
R
N
N
T
V
S
S
Q
I
T
A
S
S
S
L
T
T
D
V
G
N
A
T
S
A
N
I
W
S
A
N
A
E
S
N
T
S
S
S
P
L
180
181
F
D
Y
P
L
A
T
S
Y
F
E
P
L
T
R
F
K
S
T
D
N
Y
T
L
P
Q
T
A
Q
L
N
S
F
L
E
K
N
G
N
P
N
I
W
S
S
A
G
N
S
N
T
D
H
L
N
T
P
I
V
N
240
241
R
Q
R
S
Q
S
Q
S
T
T
N
R
V
Y
T
D
A
P
Y
Y
Q
Q
P
A
Q
N
Y
Q
V
Q
V
P
P
R
V
P
K
S
T
S
I
S
P
V
I
L
D
D
V
D
P
A
S
I
N
W
I
T
A
N
300
301
Q
K
V
P
L
V
N
Q
I
S
A
L
L
P
T
N
T
I
S
I
S
N
V
F
P
L
Q
P
T
Q
Q
H
Q
Q
N
A
V
N
L
T
S
T
S
L
A
T
L
C
S
Q
Y
G
K
V
L
S
A
R
T
L
360
361
R
G
L
N
M
A
L
V
E
F
S
T
V
E
S
A
I
C
A
L
E
A
L
Q
G
K
E
L
S
K
V
G
A
P
S
T
V
S
F
A
R
V
L
P
M
Y
E
Q
P
L
N
V
N
G
F
N
N
T
P
K
420
421
Q
P
L
L
Q
E
Q
L
N
H
G
V
L
N
Y
Q
L
Q
Q
S
L
Q
Q
P
E
L
Q
Q
Q
P
T
S
F
N
Q
P
N
L
T
Y
C
N
P
T
Q
N
L
S
H
L
Q
L
S
S
N
E
N
E
P
Y
480
481
P
F
P
L
P
P
P
S
L
S
D
S
K
K
D
I
L
H
T
I
S
S
F
K
L
E
Y
D
H
L
E
L
N
H
L
L
Q
N
A
L
K
N
K
G
V
S
D
T
N
Y
F
G
P
L
P
E
H
N
S
K
540
541
V
P
K
R
K
D
T
F
D
A
P
K
L
R
E
L
R
K
Q
F
D
S
N
S
L
S
T
I
E
M
E
Q
L
A
I
V
M
L
D
Q
L
P
E
L
S
S
D
Y
L
G
N
T
V
I
Q
K
L
F
E
N
600
601
S
S
N
I
I
R
D
I
M
L
R
K
C
N
K
Y
L
T
S
M
G
V
H
K
N
G
T
W
V
C
Q
K
I
I
K
M
A
N
T
P
R
Q
I
N
L
V
T
S
G
V
S
D
Y
C
T
P
L
F
N
D
660
661
Q
F
G
N
Y
V
I
Q
G
I
L
K
F
G
F
P
W
N
S
F
I
F
E
S
V
L
S
H
F
W
T
I
V
Q
N
R
Y
G
S
R
A
V
R
A
C
L
E
A
D
S
I
I
T
Q
C
Q
L
L
T
I
720
721
T
S
L
I
I
V
L
S
P
Y
L
A
T
D
T
N
G
T
L
L
I
T
W
L
L
D
T
C
T
L
P
N
K
N
L
I
L
C
D
K
L
V
N
K
N
L
V
K
L
C
C
H
K
L
G
S
L
T
V
L
780
781
K
I
L
N
L
R
G
G
E
E
E
A
L
S
K
N
K
I
I
H
A
I
F
D
G
P
I
S
S
D
S
I
L
F
Q
I
L
D
E
G
N
Y
G
P
T
F
I
Y
K
V
L
T
S
R
I
L
D
N
S
V
840
841
R
D
E
A
I
T
K
I
R
Q
L
I
L
N
S
N
I
N
L
Q
S
R
Q
L
L
E
E
V
G
L
S
S
A
G
I
S
P
K
Q
S
S
K
N
H
R
K
Q
H
P
Q
G
F
H
S
P
G
R
A
R
G
900
901
V
S
V
S
S
V
R
S
S
N
S
R
H
N
S
V
I
Q
M
N
N
A
G
P
T
P
A
L
N
F
N
P
A
P
M
S
E
I
N
S
Y
F
N
N
Q
Q
V
V
Y
S
G
N
Q
N
Q
N
Q
N
G
N
960
961
S
N
G
L
D
E
L
N
S
Q
F
D
S
F
R
I
A
N
G
T
N
L
S
L
P
I
V
N
L
P
N
V
S
N
N
N
N
N
Y
N
N
S
G
Y
S
S
Q
M
N
P
L
S
R
S
V
S
H
N
N
N
1020
1021
N
N
T
N
N
Y
N
N
N
D
N
D
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
S
N
N
S
N
N
N
N
N
N
D
T
S
L
Y
R
Y
R
S
Y
G
Y
1075
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1193
Peptide:
TRNNTV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12221
UniProt Name:
PUF2_YEAST
Protein Name:
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Position:
139-144
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-74.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-2.04
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1194 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
S
Q
I
L
P
L
A
G
A
I
S
V
A
S
G
F
W
I
P
D
F
S
N
K
Q
N
S
N
S
Y
P
G
Q
Y
K
G
K
G
G
Y
Q
D
D
C
G
D
D
Y
K
K
G
Y
K
S
K
T
Y
60
61
S
K
V
K
P
I
T
S
T
D
C
T
T
P
I
Q
P
T
G
T
T
T
G
Y
T
K
D
V
V
E
S
T
S
Y
T
T
D
T
A
Y
T
T
T
V
I
T
V
T
K
C
D
G
G
S
C
S
H
T
A
V
120
121
T
T
G
V
T
I
I
T
V
T
T
N
D
V
I
T
E
Y
T
T
Y
C
P
L
T
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
180
181
E
S
T
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
240
241
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
A
S
T
E
T
A
S
S
T
P
V
E
S
T
V
I
V
P
S
T
T
V
I
T
V
S
S
C
Y
E
D
K
C
S
V
S
S
V
T
T
G
V
V
T
I
300
301
S
S
E
E
T
I
Y
T
T
Y
C
P
I
T
S
S
I
T
I
P
V
P
N
T
S
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
360
361
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
420
421
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
A
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
480
481
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
S
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
G
T
E
A
T
P
V
T
T
Q
P
540
541
V
S
V
L
S
T
S
Q
V
V
T
A
S
G
E
F
S
T
V
T
A
H
S
T
S
I
V
A
S
C
P
E
G
G
C
V
P
E
G
Q
Q
T
E
T
S
P
S
V
P
T
N
G
P
E
V
E
A
S
S
S
600
601
V
L
S
I
P
V
S
S
V
T
T
S
T
I
A
S
S
S
E
T
S
V
P
P
A
Q
V
S
T
F
E
G
S
G
S
A
L
K
K
P
Y
Y
G
L
A
V
A
A
L
V
Y
F
M
653
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1194
Peptide:
TTGVTI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
G1UBC2
UniProt Name:
G1UBC2_CANAL
Protein Name:
Cell wall adhesin EAP1
Position:
121-126
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.5
Area of the profile Above Threshold (AGGRESCAN):
1.36
Best Energy Score (PASTA 2.0):
-2.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1195 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
L
S
T
A
Q
L
I
A
I
A
Y
Y
M
L
S
I
G
A
T
V
P
Q
V
D
G
Q
G
E
T
E
E
A
L
I
Q
K
R
S
Y
D
Y
Y
Q
E
P
C
D
D
Y
P
Q
Q
Q
Q
Q
E
E
P
60
61
C
D
Y
P
Q
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
120
121
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
Q
P
D
D
N
P
P
I
P
N
I
P
T
D
W
I
P
N
I
P
T
D
W
I
P
D
I
P
E
K
P
180
181
T
T
P
A
T
T
P
N
I
P
A
T
T
T
T
S
E
S
S
S
S
S
S
S
S
S
S
T
T
P
K
T
S
A
S
T
T
P
E
S
S
V
P
A
T
T
P
N
T
S
V
P
T
T
S
S
E
S
T
T
240
241
P
A
T
S
P
E
S
S
V
P
V
T
S
G
S
S
I
L
A
T
T
S
E
S
S
S
A
P
A
T
T
P
N
T
S
V
P
T
T
T
T
E
T
K
S
S
S
T
P
L
T
T
T
T
E
H
D
T
T
V
300
301
V
T
V
T
S
C
S
N
S
V
C
T
E
S
E
V
T
T
G
V
I
V
I
T
S
K
D
T
I
Y
T
T
Y
C
P
L
T
E
T
T
P
V
S
T
A
P
A
T
E
T
P
T
G
T
V
S
T
S
T
E
360
361
Q
S
T
T
V
I
T
V
T
S
C
S
E
S
S
C
T
E
S
E
V
T
T
G
V
V
V
V
T
S
E
E
T
V
Y
T
T
F
C
P
L
T
E
N
T
P
G
T
D
S
T
P
E
A
S
I
P
P
M
E
420
421
T
I
P
A
G
S
E
P
S
M
P
A
G
E
T
S
P
A
V
P
K
S
D
V
P
A
T
E
S
A
P
A
P
G
M
T
P
A
G
T
E
T
K
P
A
A
P
K
S
S
A
P
A
T
E
P
S
P
V
A
480
481
P
G
T
E
S
A
P
A
G
S
S
G
A
I
T
I
P
E
S
S
A
V
V
S
T
T
E
G
A
I
P
T
T
L
E
S
V
P
L
M
Q
P
S
A
N
Y
S
S
V
A
P
I
S
T
F
E
G
A
G
N
540
541
N
M
R
L
T
F
G
A
A
I
I
G
I
A
A
F
L
I
558
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1195
Peptide:
TTGVVV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B2L5Z5
UniProt Name:
B2L5Z5_9ASCO
Protein Name:
Caf1 hyphal wall protein 1
Position:
382-387
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.5
Tango:
1.28
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.6
Area of the profile Above Threshold (AGGRESCAN):
2.63
Best Energy Score (PASTA 2.0):
-4.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1196 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1196
Peptide:
TTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.7
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
56.7
Area of the profile Above Threshold (AGGRESCAN):
3.68
Best Energy Score (PASTA 2.0):
-6.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1197 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
R
P
F
P
F
A
Y
L
V
L
S
L
L
F
Y
S
A
L
G
F
P
T
A
L
V
P
R
G
S
S
E
G
T
S
C
N
S
I
V
N
G
C
P
N
L
D
F
N
W
H
M
N
Q
Q
N
I
M
Q
60
61
Y
T
L
D
V
T
S
V
S
W
V
Q
D
N
T
Y
Q
I
T
I
H
V
K
G
E
E
N
I
D
L
K
Y
L
S
S
L
K
I
I
G
V
T
G
P
K
D
T
V
Q
L
Y
G
Y
D
E
N
T
D
W
I
120
121
D
N
P
L
V
S
R
C
D
E
N
T
Y
L
I
D
N
P
T
D
F
T
A
T
F
E
V
Y
A
T
Q
D
V
N
S
C
Q
V
W
M
P
N
F
Q
I
Q
F
E
Y
L
Q
G
S
A
A
E
Y
A
C
S
180
181
W
E
W
G
T
T
S
F
Y
L
S
T
G
C
D
N
Y
D
N
Q
G
Y
S
Q
T
D
F
P
G
F
Y
W
N
I
D
C
D
N
N
C
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
240
241
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
300
301
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
360
361
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
420
421
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
480
481
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
A
P
S
S
S
T
T
E
S
S
S
A
P
540
541
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
600
601
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
660
661
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
720
721
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
780
781
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
V
P
T
P
S
S
S
T
T
E
S
S
840
841
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
900
901
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
S
K
Y
P
G
S
Q
T
E
T
S
V
S
S
T
T
960
961
E
T
T
I
V
P
T
T
T
T
T
S
V
T
T
P
S
T
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
I
T
T
T
V
P
C
S
T
S
P
S
E
T
A
S
1020
1021
E
S
T
T
T
S
P
T
T
P
V
T
T
V
V
S
T
T
V
V
T
T
E
Y
S
T
S
T
K
P
G
G
E
I
T
T
T
F
V
T
K
N
I
P
T
T
Y
L
T
T
I
A
P
T
P
S
V
T
T
V
1080
1081
T
N
F
T
P
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
V
T
T
T
V
P
C
S
T
G
T
G
E
Y
T
T
E
A
T
T
P
V
T
T
A
V
T
T
T
1140
1141
V
V
T
T
E
S
S
T
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
V
P
T
T
Y
V
T
T
L
A
P
S
A
P
V
T
P
A
T
S
A
V
P
T
T
I
T
T
T
E
C
S
A
A
T
N
1200
1201
A
A
G
E
T
T
S
V
C
S
A
K
T
I
V
S
S
A
S
A
G
E
N
T
T
P
V
T
T
A
I
P
T
T
V
V
T
T
E
S
S
V
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
I
P
1260
1261
T
T
Y
I
T
T
L
I
P
G
S
N
G
A
K
N
Y
E
T
V
A
T
A
T
N
P
I
S
I
K
T
T
S
Q
L
A
T
T
A
S
A
S
S
M
A
P
V
V
T
S
P
S
L
T
G
P
L
Q
S
A
1320
1321
S
G
S
A
V
A
T
Y
S
V
P
S
I
S
S
T
Y
Q
G
A
A
N
I
K
V
L
G
N
F
M
W
L
L
L
A
L
P
V
V
F
1360
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1197
Peptide:
TTVVST
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
E9P9G2
UniProt Name:
E9P9G2_YEASX
Protein Name:
Flocculin
Position:
1032-1037
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.06
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.5
Area of the profile Above Threshold (AGGRESCAN):
2.44
Best Energy Score (PASTA 2.0):
-4.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1198 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
R
P
F
P
F
A
Y
L
V
L
S
L
L
F
Y
S
A
L
G
F
P
T
A
L
V
P
R
G
S
S
E
G
T
S
C
N
S
I
V
N
G
C
P
N
L
D
F
N
W
H
M
N
Q
Q
N
I
M
Q
60
61
Y
T
L
D
V
T
S
V
S
W
V
Q
D
N
T
Y
Q
I
T
I
H
V
K
G
E
E
N
I
D
L
K
Y
L
S
S
L
K
I
I
G
V
T
G
P
K
D
T
V
Q
L
Y
G
Y
D
E
N
T
D
W
I
120
121
D
N
P
L
V
S
R
C
D
E
N
T
Y
L
I
D
N
P
T
D
F
T
A
T
F
E
V
Y
A
T
Q
D
V
N
S
C
Q
V
W
M
P
N
F
Q
I
Q
F
E
Y
L
Q
G
S
A
A
E
Y
A
C
S
180
181
W
E
W
G
T
T
S
F
Y
L
S
T
G
C
D
N
Y
D
N
Q
G
Y
S
Q
T
D
F
P
G
F
Y
W
N
I
D
C
D
N
N
C
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
240
241
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
300
301
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
360
361
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
420
421
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
480
481
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
A
P
S
S
S
T
T
E
S
S
S
A
P
540
541
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
600
601
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
660
661
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
720
721
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
780
781
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
V
P
T
P
S
S
S
T
T
E
S
S
840
841
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
900
901
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
S
K
Y
P
G
S
Q
T
E
T
S
V
S
S
T
T
960
961
E
T
T
I
V
P
T
T
T
T
T
S
V
T
T
P
S
T
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
I
T
T
T
V
P
C
S
T
S
P
S
E
T
A
S
1020
1021
E
S
T
T
T
S
P
T
T
P
V
T
T
V
V
S
T
T
V
V
T
T
E
Y
S
T
S
T
K
P
G
G
E
I
T
T
T
F
V
T
K
N
I
P
T
T
Y
L
T
T
I
A
P
T
P
S
V
T
T
V
1080
1081
T
N
F
T
P
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
V
T
T
T
V
P
C
S
T
G
T
G
E
Y
T
T
E
A
T
T
P
V
T
T
A
V
T
T
T
1140
1141
V
V
T
T
E
S
S
T
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
V
P
T
T
Y
V
T
T
L
A
P
S
A
P
V
T
P
A
T
S
A
V
P
T
T
I
T
T
T
E
C
S
A
A
T
N
1200
1201
A
A
G
E
T
T
S
V
C
S
A
K
T
I
V
S
S
A
S
A
G
E
N
T
T
P
V
T
T
A
I
P
T
T
V
V
T
T
E
S
S
V
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
I
P
1260
1261
T
T
Y
I
T
T
L
I
P
G
S
N
G
A
K
N
Y
E
T
V
A
T
A
T
N
P
I
S
I
K
T
T
S
Q
L
A
T
T
A
S
A
S
S
M
A
P
V
V
T
S
P
S
L
T
G
P
L
Q
S
A
1320
1321
S
G
S
A
V
A
T
Y
S
V
P
S
I
S
S
T
Y
Q
G
A
A
N
I
K
V
L
G
N
F
M
W
L
L
L
A
L
P
V
V
F
1360
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1198
Peptide:
TTVVTT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
E9P9G2
UniProt Name:
E9P9G2_YEASX
Protein Name:
Flocculin
Position:
1037-1042
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.3
Area of the profile Above Threshold (AGGRESCAN):
2.55
Best Energy Score (PASTA 2.0):
-5.43
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1199 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1199
Peptide:
TVFHIG
Length:
6
Classification:
Non-amyloid
Mutation(s):
P1824H
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1821-1826
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.0
Area of the profile Above Threshold (AGGRESCAN):
2.28
Best Energy Score (PASTA 2.0):
-4.86
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1200 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1200
Peptide:
TVFPIG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1821-1826
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.32
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
48.9
Area of the profile Above Threshold (AGGRESCAN):
2.31
Best Energy Score (PASTA 2.0):
-1.09
Aggregate Orientation (PASTA 2.0):
Antiparallel
