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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1231 to 1260 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1231
VHIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624H
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1232
VHNNSN
6
Non-amyloid
Transcriptional activator/repressor MOT3
P54785
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1233
VIFTIM
6
Amyloid
Nucleoside diphosphate kinase homolog 5 (NDK-H 5)
P56597
No
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-1234
VIGIAQ
6
Amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1235
VIIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624I
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1236
VILLIS
6
Amyloid
Major prion protein (PrP)
P04156
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1237
VISLSG
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1238
VIVATT
6
Amyloid
Agglutinin-like protein 1 (Adhesin 1)
Q5A8T4
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1239
VIVIRT
6
Non-amyloid
Flocculation protein FLO1 (Flocculin-1)
P32768
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1240
VIWIAQ
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
G151W
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1241
VKAVAK
6
Amyloid
Alpha-synuclein
P37840
T75K, Q79K
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1242
VKIVYK
6
Amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624K
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):191-6.
24367077
AmyLoad, Waltz-DB 2.0
P-1243
VKKEEK
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1244
VKQFGG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1245
VKWDRD
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1246
VLIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624L
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1247
VLVEAQ
6
amyloid
Zona pellucida sperm-binding protein 3
P21754
C46A
FEBS Lett. 2016 Mar;590(5):619-30.
26879157
Waltz-DB 2.0
P-1248
VMIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624M
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1249
VNIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624N
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1250
VNNNNI
6
Non-amyloid
SWI/SNF chromatin-remodeling complex subunit SWI1
P09547
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1251
VNNNNN
6
Non-amyloid
Transcriptional regulator URE2
P23202
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1252
VNQLYQ
6
Amyloid
Nuclear cap-binding protein subunit 1
Q09161
No
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-1253
VNVTQV
6
Amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1254
VNWCER
6
Non-amyloid
Low-density lipoprotein receptor (LDL receptor)
P01130
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1255
VNWYER
6
Non-amyloid
Low-density lipoprotein receptor (LDL receptor)
P01130
C667Y
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1256
VPGIAQ
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
I150P
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1257
VPIVYK
6
non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624P
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1258
VPQYGG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1259
VQAVYK
6
non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
I625A
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1260
VQCVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
I625C
Switch Lab
SwitchLab
Waltz-DB 2.0
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Entry: P-1231 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1231
Peptide:
VHIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624H
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.71
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
58.6
Area of the profile Above Threshold (AGGRESCAN):
3.88
Best Energy Score (PASTA 2.0):
-6.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1232 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
A
D
H
H
L
Q
Q
Q
Q
Q
Q
R
Q
Q
H
Q
Q
Q
Q
H
Q
Q
Q
Q
H
Q
H
Q
H
Q
Q
Q
Q
H
T
I
L
Q
N
V
S
N
T
N
N
I
G
S
D
S
L
A
S
Q
P
F
N
T
60
61
T
T
V
S
S
N
K
D
D
V
M
V
N
S
G
A
R
E
L
P
M
P
L
H
Q
Q
Q
Y
I
Y
P
Y
Y
Q
Y
T
S
N
N
S
N
N
N
N
V
T
A
G
N
N
M
S
A
S
P
I
V
H
N
N
120
121
S
N
N
S
N
N
S
N
I
S
A
S
D
Y
T
V
A
N
N
S
T
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
H
P
N
Q
F
T
A
A
A
N
M
N
S
N
A
A
A
A
A
Y
Y
S
180
181
F
P
T
A
N
M
P
I
P
Q
Q
D
Q
Q
Y
M
F
N
P
A
S
Y
I
S
H
Y
Y
S
A
V
N
S
N
N
N
G
N
N
A
A
N
N
G
S
N
N
S
S
H
S
A
P
A
P
A
P
G
P
P
H
240
241
H
H
H
H
H
S
N
T
H
N
N
L
N
N
G
G
A
V
N
T
N
N
A
P
Q
H
H
P
T
I
I
T
D
Q
F
Q
F
Q
L
Q
Q
N
P
S
P
N
L
N
L
N
I
N
P
A
Q
P
L
H
L
P
300
301
P
G
W
K
I
N
T
M
P
Q
P
R
P
T
T
A
P
N
H
P
P
A
P
V
P
S
S
N
P
V
A
S
N
L
V
P
A
P
S
S
D
H
K
Y
I
H
Q
C
Q
F
C
E
K
S
F
K
R
K
S
W
360
361
L
K
R
H
L
L
S
H
S
Q
Q
R
H
F
L
C
P
W
C
L
S
R
Q
K
R
K
D
N
L
L
Q
H
M
K
L
K
H
T
N
Y
L
L
D
E
L
K
K
N
N
I
I
F
N
Y
N
N
S
S
S
S
420
421
N
N
N
N
D
N
N
N
N
N
N
S
N
S
A
S
G
S
G
G
A
G
A
A
A
A
A
A
T
A
P
E
N
E
D
G
N
G
Y
D
T
N
I
K
T
L
I
N
D
G
V
L
N
K
D
D
V
K
R
V
480
481
L
N
N
L
I
V
S
H
N
K
490
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1232
Peptide:
VHNNSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P54785
UniProt Name:
MOT3_YEAST
Protein Name:
Transcriptional activator/repressor MOT3
Position:
117-122
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.12
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-84.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1233 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
V
I
F
T
I
M
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1233
Peptide:
VIFTIM
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P56597
UniProt Name:
NDK5_HUMAN
Protein Name:
Nucleoside diphosphate kinase homolog 5 (NDK-H 5)
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.0
Tango:
59.97
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
87.5
Area of the profile Above Threshold (AGGRESCAN):
5.72
Best Energy Score (PASTA 2.0):
-7.1
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1234 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1234
Peptide:
VIGIAQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
149-154
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.85
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.1
Area of the profile Above Threshold (AGGRESCAN):
2.93
Best Energy Score (PASTA 2.0):
-4.61
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1235 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1235
Peptide:
VIIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624I
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
1.0
Tango:
104.41
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
96.6
Area of the profile Above Threshold (AGGRESCAN):
6.45
Best Energy Score (PASTA 2.0):
-8.39
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1236 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1236
Peptide:
VILLIS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
240-245
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.08
Tango:
37.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
98.7
Area of the profile Above Threshold (AGGRESCAN):
6.51
Best Energy Score (PASTA 2.0):
-7.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1237 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1237
Peptide:
VISLSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
104-109
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
34.6
Area of the profile Above Threshold (AGGRESCAN):
2.79
Best Energy Score (PASTA 2.0):
-4.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1238 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
Q
Q
F
T
L
L
F
L
Y
L
S
I
A
S
A
K
T
I
T
G
V
F
D
S
F
N
S
L
T
W
S
N
A
A
N
Y
A
F
K
G
P
G
Y
P
T
W
N
A
V
L
G
W
S
L
D
G
T
S
60
61
A
N
P
G
D
T
F
T
L
N
M
P
C
V
F
K
Y
T
T
S
Q
T
S
V
D
L
T
A
D
G
V
K
Y
A
T
C
Q
F
Y
S
G
E
E
F
T
T
F
S
T
L
T
C
T
V
N
D
A
L
K
S
120
121
S
I
K
A
F
G
T
V
T
L
P
I
A
F
N
V
G
G
T
G
S
S
T
D
L
E
D
S
K
C
F
T
A
G
T
N
T
V
T
F
N
D
G
D
K
D
I
S
I
D
V
E
F
E
K
S
T
V
D
P
180
181
S
G
Y
L
Y
A
S
R
V
M
P
S
L
N
K
V
T
T
L
F
V
A
P
Q
C
E
N
G
Y
T
S
G
T
M
G
F
S
S
S
N
G
D
V
A
I
D
C
S
N
I
H
I
G
I
T
K
G
L
N
D
240
241
W
N
Y
P
V
S
S
E
S
F
S
Y
T
K
T
C
T
S
N
G
I
Q
I
K
Y
Q
N
V
P
A
G
Y
R
P
F
I
D
A
Y
I
S
A
T
D
V
N
Q
Y
T
L
A
Y
T
N
D
Y
T
C
A
G
300
301
S
R
S
Q
S
K
P
F
T
L
R
W
T
G
Y
K
N
S
D
A
G
S
N
G
I
V
I
V
A
T
T
R
T
V
T
D
S
T
T
A
V
T
T
L
P
F
N
P
S
V
D
K
T
K
T
I
E
I
L
Q
360
361
P
I
P
T
T
T
I
T
T
S
Y
V
G
V
T
T
S
Y
S
T
K
T
A
P
I
G
E
T
A
T
V
I
V
D
V
P
Y
H
T
T
T
T
V
T
S
E
W
T
G
T
I
T
T
T
T
T
R
T
N
P
420
421
T
D
S
I
D
T
V
V
V
Q
V
P
S
P
N
P
T
V
S
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
480
481
S
Q
S
F
A
T
T
T
T
V
T
A
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
540
541
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
I
T
A
600
601
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
660
661
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
720
721
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
F
A
T
T
T
T
V
T
A
780
781
P
P
G
G
T
D
T
V
I
I
Y
E
S
M
S
S
S
K
I
S
T
S
S
N
D
I
T
S
I
I
P
S
F
S
R
P
H
Y
V
N
S
T
T
S
D
L
S
T
F
E
S
S
S
M
N
T
P
T
S
I
840
841
S
S
D
G
M
L
L
S
S
T
T
L
V
T
E
S
E
T
T
T
E
S
I
C
S
D
G
K
E
C
S
R
L
S
S
S
S
G
I
V
T
N
P
D
S
N
E
S
S
I
V
T
S
T
V
P
T
A
S
T
900
901
M
S
D
S
L
S
S
T
D
G
I
S
A
T
S
S
D
N
V
S
K
S
G
V
S
V
T
T
E
T
S
V
T
T
I
Q
T
T
P
N
P
L
S
S
S
V
T
S
L
T
Q
L
S
S
I
P
S
V
S
E
960
961
S
E
S
K
V
T
F
T
S
N
G
D
N
Q
S
G
T
H
D
S
Q
S
T
S
T
E
I
E
I
V
T
T
S
S
T
K
V
L
P
P
V
V
S
S
N
T
D
L
T
S
E
P
T
N
T
R
E
Q
P
T
1020
1021
T
L
S
T
T
S
N
S
I
T
E
D
I
T
T
S
Q
P
T
G
D
N
G
D
N
T
S
S
T
N
P
V
P
T
V
A
T
S
T
L
A
S
A
S
E
E
D
N
K
S
G
S
H
E
S
A
S
T
S
L
1080
1081
K
P
S
M
G
E
N
S
G
L
T
T
S
T
E
I
E
A
T
T
T
S
P
T
E
A
P
S
P
A
V
S
S
G
T
D
V
T
T
E
P
T
D
T
R
E
Q
P
T
T
L
S
T
T
S
K
T
N
S
E
1140
1141
S
V
A
T
T
Q
A
T
N
E
N
G
G
K
S
P
S
T
D
L
T
S
S
L
T
T
G
T
S
A
S
T
S
A
N
S
E
L
V
T
S
G
S
V
T
G
G
A
V
A
S
A
S
N
D
Q
S
H
S
T
1200
1201
S
V
T
N
S
N
S
I
V
S
N
T
P
Q
T
T
L
S
Q
Q
V
T
S
S
S
P
S
T
N
T
F
I
A
S
T
Y
D
G
S
G
S
I
I
Q
H
S
T
W
L
Y
G
L
I
T
L
L
S
L
F
I
1260
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1238
Peptide:
VIVATT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q5A8T4
UniProt Name:
ALS1_CANAL
Protein Name:
Agglutinin-like protein 1 (Adhesin 1)
Position:
326-331
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.67
Tango:
2.15
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
49.6
Area of the profile Above Threshold (AGGRESCAN):
3.44
Best Energy Score (PASTA 2.0):
-5.64
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1239 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
M
P
H
R
Y
M
F
L
A
V
F
T
L
L
A
L
T
S
V
A
S
G
A
T
E
A
C
L
P
A
G
Q
R
K
S
G
M
N
I
N
F
Y
Q
Y
S
L
K
D
S
S
T
Y
S
N
A
A
Y
M
60
61
A
Y
G
Y
A
S
K
T
K
L
G
S
V
G
G
Q
T
D
I
S
I
D
Y
N
I
P
C
V
S
S
S
G
T
F
P
C
P
Q
E
D
S
Y
G
N
W
G
C
K
G
M
G
A
C
S
N
S
Q
G
I
A
120
121
Y
W
S
T
D
L
F
G
F
Y
T
T
P
T
N
V
T
L
E
M
T
G
Y
F
L
P
P
Q
T
G
S
Y
T
F
K
F
A
T
V
D
D
S
A
I
L
S
V
G
G
A
T
A
F
N
C
C
A
Q
Q
Q
180
181
P
P
I
T
S
T
N
F
T
I
D
G
I
K
P
W
G
G
S
L
P
P
N
I
E
G
T
V
Y
M
Y
A
G
Y
Y
Y
P
M
K
V
V
Y
S
N
A
V
S
W
G
T
L
P
I
S
V
T
L
P
D
G
240
241
T
T
V
S
D
D
F
E
G
Y
V
Y
S
F
D
D
D
L
S
Q
S
N
C
T
V
P
D
P
S
N
Y
A
V
S
T
T
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
300
301
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
T
A
S
T
I
I
T
T
T
E
P
W
N
S
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
V
R
T
D
E
T
I
I
V
I
R
T
P
360
361
T
T
A
T
T
A
I
T
T
T
E
P
W
N
S
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
420
421
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
480
481
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
I
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
540
541
T
T
A
T
T
A
M
T
T
P
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
I
T
T
T
E
P
W
N
S
600
601
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
I
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
660
661
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
I
T
T
V
T
G
T
T
G
L
P
T
D
E
T
I
I
V
I
R
T
P
720
721
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
780
781
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
V
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
I
T
G
T
840
841
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
I
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
900
901
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
H
V
T
G
T
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
960
961
T
F
T
S
T
S
T
E
V
T
T
I
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
1020
1021
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
V
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
S
T
V
T
G
T
N
G
L
P
T
D
E
T
V
I
V
V
K
T
P
1080
1081
T
T
A
I
S
S
S
L
S
S
S
S
S
G
Q
I
T
S
S
I
T
S
S
R
P
I
I
T
P
F
Y
P
S
N
G
T
S
V
I
S
S
S
V
I
S
S
S
V
T
S
S
L
F
T
S
S
P
V
I
S
1140
1141
S
S
V
I
S
S
S
T
T
T
S
T
S
I
F
S
E
S
S
K
S
S
V
I
P
T
S
S
S
T
S
G
S
S
E
S
E
T
S
S
A
G
S
V
S
S
S
S
F
I
S
S
E
S
S
K
S
P
T
Y
1200
1201
S
S
S
S
L
P
L
V
T
S
A
T
T
S
Q
E
T
A
S
S
L
P
P
A
T
T
T
K
T
S
E
Q
T
T
L
V
T
V
T
S
C
E
S
H
V
C
T
E
S
I
S
P
A
I
V
S
T
A
T
V
1260
1261
T
V
S
G
V
T
T
E
Y
T
T
W
C
P
I
S
T
T
E
T
T
K
Q
T
K
G
T
T
E
Q
T
T
E
T
T
K
Q
T
T
V
V
T
I
S
S
C
E
S
D
V
C
S
K
T
A
S
P
A
I
V
1320
1321
S
T
S
T
A
T
I
N
G
V
T
T
E
Y
T
T
W
C
P
I
S
T
T
E
S
R
Q
Q
T
T
L
V
T
V
T
S
C
E
S
G
V
C
S
E
T
A
S
P
A
I
V
S
T
A
T
A
T
V
N
D
1380
1381
V
V
T
V
Y
P
T
W
R
P
Q
T
A
N
E
E
S
V
S
S
K
M
N
S
A
T
G
E
T
T
T
N
T
L
A
A
E
T
T
T
N
T
V
A
A
E
T
I
T
N
T
G
A
A
E
T
K
T
V
V
1440
1441
T
S
S
L
S
R
S
N
H
A
E
T
Q
T
A
S
A
T
D
V
I
G
H
S
S
S
V
V
S
V
S
E
T
G
N
T
K
S
L
T
S
S
G
L
S
T
M
S
Q
Q
P
R
S
T
P
A
S
S
M
V
1500
1501
G
Y
S
T
A
S
L
E
I
S
T
Y
A
G
S
A
N
S
L
L
A
G
S
G
L
S
V
F
I
A
S
L
L
L
A
I
I
1537
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1239
Peptide:
VIVIRT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32768
UniProt Name:
FLO1_YEAST
Protein Name:
Flocculation protein FLO1 (Flocculin-1)
Position:
309-314
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.69
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
72.4
Area of the profile Above Threshold (AGGRESCAN):
4.99
Best Energy Score (PASTA 2.0):
-7.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1240 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1240
Peptide:
VIWIAQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
G151W
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
149-154
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.04
Tango:
2.4
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
66.6
Area of the profile Above Threshold (AGGRESCAN):
4.59
Best Energy Score (PASTA 2.0):
-6.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1241 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1241
Peptide:
VKAVAK
Length:
6
Classification:
Amyloid
Mutation(s):
T75K, Q79K
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
74-79
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.8
Area of the profile Above Threshold (AGGRESCAN):
0.81
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1242 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
180
181
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
240
241
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
300
301
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
360
361
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
420
421
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
441
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1242
Peptide:
VKIVYK
Length:
6
Classification:
Amyloid
Mutation(s):
Q624K
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
24367077
Reference:
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):191-6.
source:
AmyLoad, Waltz-DB 2.0
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
59.9
Area of the profile Above Threshold (AGGRESCAN):
3.97
Best Energy Score (PASTA 2.0):
-5.08
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1243 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1243
Peptide:
VKKEEK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
193-198
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
16.67
NuAPRpred:
-0.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-89.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.81
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1244 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1244
Peptide:
VKQFGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
115-120
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-16.6
Area of the profile Above Threshold (AGGRESCAN):
0.15
Best Energy Score (PASTA 2.0):
-1.42
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1245 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1245
Peptide:
VKWDRD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
113-118
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
33.33
NuAPRpred:
-0.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-65.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.22
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1246 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1246
Peptide:
VLIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624L
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.94
Tango:
58.36
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
90.7
Area of the profile Above Threshold (AGGRESCAN):
6.05
Best Energy Score (PASTA 2.0):
-7.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1247 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
E
L
S
Y
R
L
F
I
C
L
L
L
W
G
S
T
E
L
C
Y
P
Q
P
L
W
L
L
Q
G
G
A
S
H
P
E
T
S
V
Q
P
V
L
V
E
C
Q
E
A
T
L
M
V
M
V
S
K
D
L
F
60
61
G
T
G
K
L
I
R
A
A
D
L
T
L
G
P
E
A
C
E
P
L
V
S
M
D
T
E
D
V
V
R
F
E
V
G
L
H
E
C
G
N
S
M
Q
V
T
D
D
A
L
V
Y
S
T
F
L
L
H
D
P
120
121
R
P
V
G
N
L
S
I
V
R
T
N
R
A
E
I
P
I
E
C
R
Y
P
R
Q
G
N
V
S
S
Q
A
I
L
P
T
W
L
P
F
R
T
T
V
F
S
E
E
K
L
T
F
S
L
R
L
M
E
E
N
180
181
W
N
A
E
K
R
S
P
T
F
H
L
G
D
A
A
H
L
Q
A
E
I
H
T
G
S
H
V
P
L
R
L
F
V
D
H
C
V
A
T
P
T
P
D
Q
N
A
S
P
Y
H
T
I
V
D
F
H
G
C
L
240
241
V
D
G
L
T
D
A
S
S
A
F
K
V
P
R
P
G
P
D
T
L
Q
F
T
V
D
V
F
H
F
A
N
D
S
R
N
M
I
Y
I
T
C
H
L
K
V
T
L
A
E
Q
D
P
D
E
L
N
K
A
C
300
301
S
F
S
K
P
S
N
S
W
F
P
V
E
G
S
A
D
I
C
Q
C
C
N
K
G
D
C
G
T
P
S
H
S
R
R
Q
P
H
V
M
S
Q
W
S
R
S
A
S
R
N
R
R
H
V
T
E
E
A
D
V
360
361
T
V
G
P
L
I
F
L
D
R
R
G
D
H
E
V
E
Q
W
A
L
P
S
D
T
S
V
V
L
L
G
V
G
L
A
V
V
V
S
L
T
L
T
A
V
I
L
V
L
T
R
R
C
R
T
A
S
H
P
V
420
421
S
A
S
E
424
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1247
Peptide:
VLVEAQ
Length:
6
Classification:
amyloid
Mutation(s):
C46A
Structure(s):
No structures
Protein Information
UniProt ID:
P21754
UniProt Name:
ZP3_HUMAN
Protein Name:
Zona pellucida sperm-binding protein 3
Position:
42-47
Literature
PMID:
26879157
Reference:
FEBS Lett. 2016 Mar;590(5):619-30.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.1
Area of the profile Above Threshold (AGGRESCAN):
1.54
Best Energy Score (PASTA 2.0):
-2.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1248 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1248
Peptide:
VMIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624M
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.7
Tango:
13.69
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
84.5
Area of the profile Above Threshold (AGGRESCAN):
5.63
Best Energy Score (PASTA 2.0):
-6.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1249 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1249
Peptide:
VNIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624N
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.7
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
55.0
Area of the profile Above Threshold (AGGRESCAN):
3.64
Best Energy Score (PASTA 2.0):
-6.39
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1250 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
F
F
N
L
N
N
N
N
N
N
N
N
T
T
T
T
T
T
T
T
N
N
N
N
T
N
N
N
N
T
N
N
N
N
N
P
A
N
N
T
N
N
N
N
S
T
G
H
S
S
N
T
N
N
N
T
N
N
60
61
N
N
T
N
T
G
A
S
G
V
D
D
F
Q
N
F
F
D
P
K
P
F
D
Q
N
L
D
S
N
N
N
N
S
N
S
N
N
N
D
N
N
N
S
N
T
V
A
S
S
T
N
F
T
S
P
T
A
V
V
N
120
121
N
A
A
P
A
N
V
T
G
G
K
A
A
N
F
I
Q
N
Q
S
P
Q
F
N
S
P
Y
D
S
N
N
S
N
T
N
L
N
S
L
S
P
Q
A
I
L
A
K
N
S
I
I
D
S
S
N
L
P
L
Q
A
180
181
Q
Q
Q
L
Y
G
G
N
N
N
N
N
S
T
G
I
A
N
D
N
V
I
T
P
H
F
I
T
N
V
Q
S
I
S
Q
N
S
S
S
S
T
P
N
T
N
S
N
S
T
P
N
A
N
Q
Q
F
L
P
F
N
240
241
N
S
A
S
N
N
G
N
L
T
S
N
Q
L
I
S
N
Y
A
A
S
N
S
M
D
R
S
S
S
A
S
N
E
F
V
P
N
T
S
D
N
N
N
N
S
N
N
H
N
M
R
N
N
S
N
N
K
T
S
N
300
301
N
N
N
V
T
A
V
P
A
A
T
P
A
N
T
N
N
S
T
S
N
A
N
T
V
F
S
E
R
A
A
M
F
A
A
L
Q
Q
K
Q
Q
Q
R
F
Q
A
L
Q
Q
Q
Q
Q
Q
Q
Q
N
Q
Q
Q
Q
360
361
N
Q
Q
P
Q
Q
Q
Q
Q
Q
Q
Q
N
P
K
F
L
Q
S
Q
R
Q
Q
Q
Q
R
S
I
L
Q
S
L
N
P
A
L
Q
E
K
I
S
T
E
L
N
N
K
Q
Y
E
L
F
M
K
S
L
I
E
N
C
420
421
K
K
R
N
M
P
L
Q
S
I
P
E
I
G
N
R
K
I
N
L
F
Y
L
Y
M
L
V
Q
K
F
G
G
A
D
Q
V
T
R
T
Q
Q
W
S
M
V
A
Q
R
L
Q
I
S
D
Y
Q
Q
L
E
S
I
480
481
Y
F
R
I
L
L
P
Y
E
R
H
M
I
S
Q
E
G
I
K
E
T
Q
A
K
R
I
F
L
Q
Q
F
L
Q
E
L
L
K
K
V
Q
Q
Q
Q
Q
A
A
A
L
A
N
A
N
N
N
I
N
S
A
S
S
540
541
A
P
T
P
A
A
P
G
A
S
V
P
A
T
A
A
P
G
T
E
A
G
I
V
P
V
S
A
N
T
P
K
S
L
N
S
N
I
N
I
N
V
N
N
N
N
I
G
Q
Q
Q
V
K
K
P
R
K
Q
R
V
600
601
K
K
K
T
K
K
E
L
E
L
E
R
K
E
R
E
D
F
Q
K
R
Q
Q
K
L
L
E
D
Q
Q
R
Q
Q
K
L
L
L
E
T
K
L
R
Q
Q
Y
E
I
E
L
K
K
L
P
K
V
Y
K
R
S
I
660
661
V
R
N
Y
K
P
L
I
N
R
L
K
H
Y
N
G
Y
D
I
N
Y
I
S
K
I
G
E
K
I
D
S
N
K
P
I
F
L
F
A
P
E
L
G
A
I
N
L
H
A
L
S
M
S
L
Q
S
K
N
L
G
720
721
E
I
N
T
A
L
N
T
L
L
V
T
S
A
D
S
N
L
K
I
S
L
V
K
Y
P
E
L
L
D
S
L
A
I
L
G
M
N
L
L
S
N
L
S
Q
N
V
V
P
Y
H
R
N
T
S
D
Y
Y
Y
E
780
781
D
A
G
S
N
Q
Y
Y
V
T
Q
H
D
K
M
V
D
K
I
F
E
K
V
N
N
N
A
T
L
T
P
N
D
S
N
D
E
K
V
T
I
L
V
D
S
L
T
G
N
Q
L
P
T
P
T
P
T
E
M
E
840
841
P
D
L
D
T
E
C
F
I
S
M
Q
S
T
S
P
A
V
K
Q
W
D
L
L
P
E
P
I
R
F
L
P
N
Q
F
P
L
K
I
H
R
T
P
Y
L
T
S
L
K
K
I
K
D
E
I
D
D
P
F
T
900
901
K
I
N
T
R
G
A
E
D
P
K
V
L
I
N
D
Q
L
S
T
I
S
M
I
L
R
N
I
S
F
S
D
N
N
S
R
I
M
S
R
N
F
Y
L
K
R
F
I
S
D
L
L
W
L
V
L
I
H
P
E
960
961
N
F
T
C
N
R
K
I
L
N
F
K
K
D
L
V
I
V
L
S
N
I
S
H
L
L
E
I
A
S
S
I
D
C
L
L
I
L
I
L
V
I
S
F
G
Q
P
K
L
N
P
M
A
S
S
S
S
F
G
S
1020
1021
E
S
L
T
F
N
E
F
Q
L
Q
W
G
K
Y
Q
T
F
G
V
D
I
L
A
K
L
F
S
L
E
K
P
N
L
N
Y
F
K
S
I
L
L
N
K
N
T
G
N
N
L
Y
D
R
N
S
N
N
N
H
K
1080
1081
D
K
K
L
L
R
R
L
L
N
L
Y
N
D
N
N
K
N
N
N
N
R
H
N
L
L
N
D
V
V
S
F
L
F
S
A
I
P
L
Q
Q
V
L
S
Q
S
A
D
P
S
L
L
I
D
Q
F
S
P
V
I
1140
1141
S
Q
S
L
T
S
I
L
V
I
V
Q
K
I
L
P
L
S
N
E
V
F
E
I
S
E
N
N
S
D
S
N
S
N
N
N
G
N
K
D
S
S
F
N
F
N
K
N
L
P
F
V
W
L
S
S
E
E
N
I
1200
1201
G
S
G
L
L
K
L
S
E
I
I
L
N
I
N
N
S
T
S
K
N
T
L
L
Q
Q
Q
N
Y
S
K
V
L
L
P
S
I
N
I
S
C
V
Q
L
I
K
C
L
V
E
K
S
I
C
F
E
N
C
L
N
1260
1261
N
D
P
E
I
L
K
K
I
A
S
I
P
N
L
F
P
T
D
L
E
I
F
Q
L
F
T
N
P
S
V
D
I
Q
I
I
N
Q
Y
Q
L
L
Y
N
L
K
N
D
I
L
T
N
L
E
1314
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1250
Peptide:
VNNNNI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09547
UniProt Name:
SWI1_YEAST
Protein Name:
SWI/SNF chromatin-remodeling complex subunit SWI1
Position:
582-587
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.41
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-70.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-3.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1251 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1251
Peptide:
VNNNNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
43-48
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
0.04
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-101.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.94
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1252 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
V
N
Q
L
Y
Q
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1252
Peptide:
VNQLYQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q09161
UniProt Name:
CB80_HUMAN
Protein Name:
Nuclear cap-binding protein subunit 1
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.4
Area of the profile Above Threshold (AGGRESCAN):
0.34
Best Energy Score (PASTA 2.0):
-1.74
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1253 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1253
Peptide:
VNVTQV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
135-140
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.7
Area of the profile Above Threshold (AGGRESCAN):
0.66
Best Energy Score (PASTA 2.0):
-4.64
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1254 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
P
W
G
W
K
L
R
W
T
V
A
L
L
L
A
A
A
G
T
A
V
G
D
R
C
E
R
N
E
F
Q
C
Q
D
G
K
C
I
S
Y
K
W
V
C
D
G
S
A
E
C
Q
D
G
S
D
E
S
Q
60
61
E
T
C
L
S
V
T
C
K
S
G
D
F
S
C
G
G
R
V
N
R
C
I
P
Q
F
W
R
C
D
G
Q
V
D
C
D
N
G
S
D
E
Q
G
C
P
P
K
T
C
S
Q
D
E
F
R
C
H
D
G
K
120
121
C
I
S
R
Q
F
V
C
D
S
D
R
D
C
L
D
G
S
D
E
A
S
C
P
V
L
T
C
G
P
A
S
F
Q
C
N
S
S
T
C
I
P
Q
L
W
A
C
D
N
D
P
D
C
E
D
G
S
D
E
W
180
181
P
Q
R
C
R
G
L
Y
V
F
Q
G
D
S
S
P
C
S
A
F
E
F
H
C
L
S
G
E
C
I
H
S
S
W
R
C
D
G
G
P
D
C
K
D
K
S
D
E
E
N
C
A
V
A
T
C
R
P
D
E
240
241
F
Q
C
S
D
G
N
C
I
H
G
S
R
Q
C
D
R
E
Y
D
C
K
D
M
S
D
E
V
G
C
V
N
V
T
L
C
E
G
P
N
K
F
K
C
H
S
G
E
C
I
T
L
D
K
V
C
N
M
A
R
300
301
D
C
R
D
W
S
D
E
P
I
K
E
C
G
T
N
E
C
L
D
N
N
G
G
C
S
H
V
C
N
D
L
K
I
G
Y
E
C
L
C
P
D
G
F
Q
L
V
A
Q
R
R
C
E
D
I
D
E
C
Q
D
360
361
P
D
T
C
S
Q
L
C
V
N
L
E
G
G
Y
K
C
Q
C
E
E
G
F
Q
L
D
P
H
T
K
A
C
K
A
V
G
S
I
A
Y
L
F
F
T
N
R
H
E
V
R
K
M
T
L
D
R
S
E
Y
T
420
421
S
L
I
P
N
L
R
N
V
V
A
L
D
T
E
V
A
S
N
R
I
Y
W
S
D
L
S
Q
R
M
I
C
S
T
Q
L
D
R
A
H
G
V
S
S
Y
D
T
V
I
S
R
D
I
Q
A
P
D
G
L
A
480
481
V
D
W
I
H
S
N
I
Y
W
T
D
S
V
L
G
T
V
S
V
A
D
T
K
G
V
K
R
K
T
L
F
R
E
N
G
S
K
P
R
A
I
V
V
D
P
V
H
G
F
M
Y
W
T
D
W
G
T
P
A
540
541
K
I
K
K
G
G
L
N
G
V
D
I
Y
S
L
V
T
E
N
I
Q
W
P
N
G
I
T
L
D
L
L
S
G
R
L
Y
W
V
D
S
K
L
H
S
I
S
S
I
D
V
N
G
G
N
R
K
T
I
L
E
600
601
D
E
K
R
L
A
H
P
F
S
L
A
V
F
E
D
K
V
F
W
T
D
I
I
N
E
A
I
F
S
A
N
R
L
T
G
S
D
V
N
L
L
A
E
N
L
L
S
P
E
D
M
V
L
F
H
N
L
T
Q
660
661
P
R
G
V
N
W
C
E
R
T
T
L
S
N
G
G
C
Q
Y
L
C
L
P
A
P
Q
I
N
P
H
S
P
K
F
T
C
A
C
P
D
G
M
L
L
A
R
D
M
R
S
C
L
T
E
A
E
A
A
V
A
720
721
T
Q
E
T
S
T
V
R
L
K
V
S
S
T
A
V
R
T
Q
H
T
T
T
R
P
V
P
D
T
S
R
L
P
G
A
T
P
G
L
T
T
V
E
I
V
T
M
S
H
Q
A
L
G
D
V
A
G
R
G
N
780
781
E
K
K
P
S
S
V
R
A
L
S
I
V
L
P
I
V
L
L
V
F
L
C
L
G
V
F
L
L
W
K
N
W
R
L
K
N
I
N
S
I
N
F
D
N
P
V
Y
Q
K
T
T
E
D
E
V
H
I
C
H
840
841
N
Q
D
G
Y
S
Y
P
S
R
Q
M
V
S
L
E
D
D
V
A
860
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1254
Peptide:
VNWCER
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01130
UniProt Name:
LDLR_HUMAN
Protein Name:
Low-density lipoprotein receptor (LDL receptor)
Position:
664-669
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.16
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-17.9
Area of the profile Above Threshold (AGGRESCAN):
0.33
Best Energy Score (PASTA 2.0):
-2.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1255 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
P
W
G
W
K
L
R
W
T
V
A
L
L
L
A
A
A
G
T
A
V
G
D
R
C
E
R
N
E
F
Q
C
Q
D
G
K
C
I
S
Y
K
W
V
C
D
G
S
A
E
C
Q
D
G
S
D
E
S
Q
60
61
E
T
C
L
S
V
T
C
K
S
G
D
F
S
C
G
G
R
V
N
R
C
I
P
Q
F
W
R
C
D
G
Q
V
D
C
D
N
G
S
D
E
Q
G
C
P
P
K
T
C
S
Q
D
E
F
R
C
H
D
G
K
120
121
C
I
S
R
Q
F
V
C
D
S
D
R
D
C
L
D
G
S
D
E
A
S
C
P
V
L
T
C
G
P
A
S
F
Q
C
N
S
S
T
C
I
P
Q
L
W
A
C
D
N
D
P
D
C
E
D
G
S
D
E
W
180
181
P
Q
R
C
R
G
L
Y
V
F
Q
G
D
S
S
P
C
S
A
F
E
F
H
C
L
S
G
E
C
I
H
S
S
W
R
C
D
G
G
P
D
C
K
D
K
S
D
E
E
N
C
A
V
A
T
C
R
P
D
E
240
241
F
Q
C
S
D
G
N
C
I
H
G
S
R
Q
C
D
R
E
Y
D
C
K
D
M
S
D
E
V
G
C
V
N
V
T
L
C
E
G
P
N
K
F
K
C
H
S
G
E
C
I
T
L
D
K
V
C
N
M
A
R
300
301
D
C
R
D
W
S
D
E
P
I
K
E
C
G
T
N
E
C
L
D
N
N
G
G
C
S
H
V
C
N
D
L
K
I
G
Y
E
C
L
C
P
D
G
F
Q
L
V
A
Q
R
R
C
E
D
I
D
E
C
Q
D
360
361
P
D
T
C
S
Q
L
C
V
N
L
E
G
G
Y
K
C
Q
C
E
E
G
F
Q
L
D
P
H
T
K
A
C
K
A
V
G
S
I
A
Y
L
F
F
T
N
R
H
E
V
R
K
M
T
L
D
R
S
E
Y
T
420
421
S
L
I
P
N
L
R
N
V
V
A
L
D
T
E
V
A
S
N
R
I
Y
W
S
D
L
S
Q
R
M
I
C
S
T
Q
L
D
R
A
H
G
V
S
S
Y
D
T
V
I
S
R
D
I
Q
A
P
D
G
L
A
480
481
V
D
W
I
H
S
N
I
Y
W
T
D
S
V
L
G
T
V
S
V
A
D
T
K
G
V
K
R
K
T
L
F
R
E
N
G
S
K
P
R
A
I
V
V
D
P
V
H
G
F
M
Y
W
T
D
W
G
T
P
A
540
541
K
I
K
K
G
G
L
N
G
V
D
I
Y
S
L
V
T
E
N
I
Q
W
P
N
G
I
T
L
D
L
L
S
G
R
L
Y
W
V
D
S
K
L
H
S
I
S
S
I
D
V
N
G
G
N
R
K
T
I
L
E
600
601
D
E
K
R
L
A
H
P
F
S
L
A
V
F
E
D
K
V
F
W
T
D
I
I
N
E
A
I
F
S
A
N
R
L
T
G
S
D
V
N
L
L
A
E
N
L
L
S
P
E
D
M
V
L
F
H
N
L
T
Q
660
661
P
R
G
V
N
W
C
E
R
T
T
L
S
N
G
G
C
Q
Y
L
C
L
P
A
P
Q
I
N
P
H
S
P
K
F
T
C
A
C
P
D
G
M
L
L
A
R
D
M
R
S
C
L
T
E
A
E
A
A
V
A
720
721
T
Q
E
T
S
T
V
R
L
K
V
S
S
T
A
V
R
T
Q
H
T
T
T
R
P
V
P
D
T
S
R
L
P
G
A
T
P
G
L
T
T
V
E
I
V
T
M
S
H
Q
A
L
G
D
V
A
G
R
G
N
780
781
E
K
K
P
S
S
V
R
A
L
S
I
V
L
P
I
V
L
L
V
F
L
C
L
G
V
F
L
L
W
K
N
W
R
L
K
N
I
N
S
I
N
F
D
N
P
V
Y
Q
K
T
T
E
D
E
V
H
I
C
H
840
841
N
Q
D
G
Y
S
Y
P
S
R
Q
M
V
S
L
E
D
D
V
A
860
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1255
Peptide:
VNWYER
Length:
6
Classification:
Non-amyloid
Mutation(s):
C667Y
Structure(s):
No structures
Protein Information
UniProt ID:
P01130
UniProt Name:
LDLR_HUMAN
Protein Name:
Low-density lipoprotein receptor (LDL receptor)
Position:
664-669
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.8
Area of the profile Above Threshold (AGGRESCAN):
0.72
Best Energy Score (PASTA 2.0):
-3.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1256 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1256
Peptide:
VPGIAQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
I150P
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
149-154
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.4
Area of the profile Above Threshold (AGGRESCAN):
0.83
Best Energy Score (PASTA 2.0):
1.3
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1257 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1257
Peptide:
VPIVYK
Length:
6
Classification:
non-amyloid
Mutation(s):
Q624P
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
-0.34
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
67.9
Area of the profile Above Threshold (AGGRESCAN):
3.88
Best Energy Score (PASTA 2.0):
-3.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1258 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1258
Peptide:
VPQYGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
23-28
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.5
Area of the profile Above Threshold (AGGRESCAN):
0.15
Best Energy Score (PASTA 2.0):
1.36
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1259 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1259
Peptide:
VQAVYK
Length:
6
Classification:
non-amyloid
Mutation(s):
I625A
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
18.8
Area of the profile Above Threshold (AGGRESCAN):
1.29
Best Energy Score (PASTA 2.0):
-2.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1260 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1260
Peptide:
VQCVYK
Length:
6
Classification:
amyloid
Mutation(s):
I625C
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.72
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
31.6
Area of the profile Above Threshold (AGGRESCAN):
2.12
Best Energy Score (PASTA 2.0):
-3.31
Aggregate Orientation (PASTA 2.0):
Antiparallel
