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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1141 to 1170 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1141
SVISLS
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1142
SVNLDV
6
amyloid
Alpha-crystallin B chain
P02511
No
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
23552370
Waltz-DB 2.0
P-1143
SVNVTQ
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1144
SVSSSY
6
amyloid
No
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
23552370
Waltz-DB 2.0
P-1145
SVVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1146
SWGMMG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1147
SWVIIE
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1148
SYLCDL
6
Non-amyloid
von Willebrand factor (vWF)
P04275
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1149
SYLYDL
6
Non-amyloid
von Willebrand factor (vWF)
P04275
C1458Y
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1150
SYNNNN
6
Non-amyloid
RNA-binding protein MRN1
Q08925
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1151
SYSGSN
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1152
SYSTMS
6
Amyloid
Ribonuclease (RNase A)
P61823
No
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
20133726
CPAD, Waltz-DB 2.0, AmyLoad
P-1153
SYVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1154
TAAHCF
6
Non-amyloid
Coagulation factor XI (FXI)
P03951
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1155
TAELIT
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1156
TAMIIQ
6
amyloid
Minor curlin subunit
P0ABK7
No
J Struct Biol. 2016 Aug;195(2):179-189.
27245712
Waltz-DB 2.0
P-1157
TAMLGT
6
amyloid
Calcitonin; Katacalcin
P01258
C91A
FEBS Lett. 2013 Mar 18;587(6):569-74.
23395606
Waltz-DB 2.0
P-1158
TASNSS
6
amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1159
TATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38T
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1160
TAVHCF
6
Non-amyloid
Coagulation factor XI (FXI)
P03951
A430V
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1161
TAVTHR
6
amyloid
Calcitonin gene-related peptide 1
P06881
C89A
J Struct Biol. 2018 Jul;203(1):27-36.
29501724
Waltz-DB 2.0
P-1162
TAVTTG
6
Non-amyloid
Cell wall adhesin EAP1
G1UBC2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1163
TAVVTN
6
amyloid
Transthyretin
P02766
No
J Biol Chem. 2015 Nov 27;290(48):28932-43.
26459562
Waltz-DB 2.0
P-1164
TAWYAE
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1165
TCMLGT
6
amyloid
Calcitonin; Katacalcin
P01258
No
FEBS Lett. 2013 Mar 18;587(6):569-74.
23395606
Waltz-DB 2.0
P-1166
TCVTHR
6
amyloid
Calcitonin gene-related peptide 1
P06881
No
J Struct Biol. 2018 Jul;203(1):27-36.
29501724
Waltz-DB 2.0
P-1167
TDETVI
6
Non-amyloid
Flocculation protein FLO1 (Flocculin-1)
P32768
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1168
TEEKKE
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
T206K
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1169
TEFTPT
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1170
TFQINS
6
Amyloid
Lysozyme C
P61626
I74T
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
20133726
CPAD, Waltz-DB 2.0, AmyLoad
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Entry: P-1141 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1141
Peptide:
SVISLS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
103-108
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.69
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.3
Area of the profile Above Threshold (AGGRESCAN):
3.03
Best Energy Score (PASTA 2.0):
-4.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1142 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
D
I
A
I
H
H
P
W
I
R
R
P
F
F
P
F
H
S
P
S
R
L
F
D
Q
F
F
G
E
H
L
L
E
S
D
L
F
P
T
S
T
S
L
S
P
F
Y
L
R
P
P
S
F
L
R
A
P
S
W
60
61
F
D
T
G
L
S
E
M
R
L
E
K
D
R
F
S
V
N
L
D
V
K
H
F
S
P
E
E
L
K
V
K
V
L
G
D
V
I
E
V
H
G
K
H
E
E
R
Q
D
E
H
G
F
I
S
R
E
F
H
R
120
121
K
Y
R
I
P
A
D
V
D
P
L
T
I
T
S
S
L
S
S
D
G
V
L
T
V
N
G
P
R
K
Q
V
S
G
P
E
R
T
I
P
I
T
R
E
E
K
P
A
V
T
A
A
P
K
K
175
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1142
Peptide:
SVNLDV
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02511
UniProt Name:
CRYAB_HUMAN
Protein Name:
Alpha-crystallin B chain
Position:
76-81
Literature
PMID:
23552370
Reference:
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.7
Area of the profile Above Threshold (AGGRESCAN):
0.31
Best Energy Score (PASTA 2.0):
-3.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1143 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1143
Peptide:
SVNVTQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
134-139
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.14
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-8.3
Area of the profile Above Threshold (AGGRESCAN):
0.46
Best Energy Score (PASTA 2.0):
-4.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1144 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
S
V
S
S
S
Y
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1144
Peptide:
SVSSSY
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
23552370
Reference:
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.8
Area of the profile Above Threshold (AGGRESCAN):
0.5
Best Energy Score (PASTA 2.0):
-1.16
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1145 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1145
Peptide:
SVVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
1.04
Tango:
3.56
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
78.7
Area of the profile Above Threshold (AGGRESCAN):
5.16
Best Energy Score (PASTA 2.0):
-7.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1146 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1146
Peptide:
SWGMMG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
333-338
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.1
Area of the profile Above Threshold (AGGRESCAN):
0.8
Best Energy Score (PASTA 2.0):
0.08
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1147 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1147
Peptide:
SWVIIE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
1.02
Tango:
1.27
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
71.3
Area of the profile Above Threshold (AGGRESCAN):
4.66
Best Energy Score (PASTA 2.0):
-6.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1148 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
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L
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Y
G
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V
A
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G
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L
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G
L
C
G
N
F
N
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A
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D
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M
T
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180
181
T
S
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Y
D
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W
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W
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240
241
V
D
P
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A
L
C
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C
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C
A
G
G
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A
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L
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M
V
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W
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A
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C
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A
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300
301
Y
R
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V
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C
A
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L
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G
L
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C
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C
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Y
P
P
G
360
361
T
S
L
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D
C
N
T
C
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W
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D
N
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L
L
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C
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D
420
421
H
S
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I
V
I
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D
D
R
D
A
V
C
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L
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L
480
481
R
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L
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Y
G
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T
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G
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C
G
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Y
N
G
N
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D
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S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
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A
V
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600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
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A
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A
A
A
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G
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V
A
W
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C
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K
G
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Y
L
Q
660
661
C
G
T
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C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
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C
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D
C
V
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K
A
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P
C
Y
Y
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P
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D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
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V
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L
L
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R
S
K
R
S
L
S
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R
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P
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V
K
L
V
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P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
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M
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G
C
L
C
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P
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R
C
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A
L
E
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C
F
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K
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Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
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C
D
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C
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A
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L
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G
L
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Y
L
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Y
V
L
V
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D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
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G
G
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N
V
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V
V
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G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
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Q
T
Y
Q
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K
V
C
G
L
C
G
N
F
D
G
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N
N
D
L
T
S
S
N
L
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V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
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H
N
N
I
M
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M
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D
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S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
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C
A
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H
G
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V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
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P
L
A
C
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V
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C
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C
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A
H
C
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P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
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D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
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V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
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P
V
C
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F
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S
C
K
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S
A
C
C
P
S
C
R
C
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R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
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L
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D
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C
D
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F
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N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
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E
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D
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A
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L
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V
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I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1148
Peptide:
SYLCDL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1455-1460
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.2
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.5
Area of the profile Above Threshold (AGGRESCAN):
1.66
Best Energy Score (PASTA 2.0):
-0.97
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1149 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1149
Peptide:
SYLYDL
Length:
6
Classification:
Non-amyloid
Mutation(s):
C1458Y
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1455-1460
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.17
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
34.6
Area of the profile Above Threshold (AGGRESCAN):
2.38
Best Energy Score (PASTA 2.0):
-1.16
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1150 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
V
S
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
S
N
N
N
N
N
N
N
M
F
P
P
F
P
S
S
D
D
F
A
M
Y
Q
Q
S
S
S
S
G
P
Y
Q
E
T
Y
A
S
G
P
Q
60
61
N
F
G
D
A
V
Y
P
M
N
G
N
F
T
L
L
P
S
D
F
T
R
E
P
N
D
S
F
F
Y
E
N
D
G
I
F
D
Y
Q
R
I
Q
Q
Q
P
T
Q
F
Q
T
K
Q
R
N
D
S
Q
Q
Q
R
120
121
F
S
Q
E
Q
N
F
E
I
D
N
E
V
V
H
N
N
N
R
Y
Y
E
Y
E
R
S
S
N
E
V
S
P
F
D
D
E
N
P
N
V
L
S
D
G
M
S
P
T
I
M
A
T
A
T
A
V
T
N
A
N
180
181
A
P
L
P
V
N
A
Q
A
N
N
P
L
N
F
T
S
A
P
S
R
T
V
Y
L
G
N
V
P
P
N
L
S
V
K
E
L
L
D
H
V
R
S
G
V
V
E
D
V
K
I
I
P
E
K
M
C
A
F
V
240
241
S
F
I
D
E
S
A
A
L
L
F
H
S
D
A
I
L
K
R
L
N
I
G
D
R
D
I
K
I
G
W
G
K
P
T
R
I
D
P
I
V
A
A
R
I
S
T
D
G
A
T
R
N
V
Y
I
G
R
M
T
300
301
I
E
G
E
E
S
H
L
S
E
E
Q
L
R
V
D
L
E
E
Y
G
E
I
D
C
I
K
I
I
K
E
K
G
I
A
F
I
H
F
A
S
I
L
N
A
I
K
V
V
T
N
L
P
I
R
N
P
Y
Y
Q
360
361
N
K
R
I
F
Y
G
K
D
R
C
A
F
I
T
K
T
Q
Q
H
N
A
A
Q
F
L
G
V
Q
P
G
M
E
H
M
I
E
F
S
D
R
E
F
I
S
N
A
L
L
Q
Q
S
A
A
A
A
A
I
A
T
420
421
S
A
G
G
P
N
N
L
G
N
R
T
V
Y
L
G
S
L
P
K
D
V
K
I
E
E
I
C
N
A
V
R
G
G
L
L
Q
S
I
K
L
L
N
D
R
Y
V
C
F
V
T
F
I
D
P
T
A
A
A
Q
480
481
F
Y
A
M
S
S
L
Y
G
F
T
V
Q
K
K
R
C
K
V
G
W
G
K
H
S
G
P
L
P
N
A
L
A
L
A
V
S
N
G
A
S
R
N
V
Y
V
G
N
I
D
F
V
G
D
S
L
R
D
E
R
540
541
V
F
T
E
S
N
L
R
H
I
F
Q
Q
Y
G
E
V
E
Q
I
N
F
L
P
E
K
N
C
C
F
I
N
Y
T
N
I
S
N
A
I
L
A
L
D
K
I
K
S
N
P
Y
F
K
D
L
K
I
N
F
G
600
601
K
D
R
C
G
N
V
P
H
Q
S
R
612
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1150
Peptide:
SYNNNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q08925
UniProt Name:
MRN1_YEAST
Protein Name:
RNA-binding protein MRN1
Position:
4-9
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-88.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.37
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1151 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1151
Peptide:
SYSGSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
373-378
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-39.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.61
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1152 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
K
S
L
V
L
L
S
L
L
V
L
V
L
L
L
V
R
V
Q
P
S
L
G
K
E
T
A
A
A
K
F
E
R
Q
H
M
D
S
S
T
S
A
A
S
S
S
N
Y
C
N
Q
M
M
K
S
R
N
60
61
L
T
K
D
R
C
K
P
V
N
T
F
V
H
E
S
L
A
D
V
Q
A
V
C
S
Q
K
N
V
A
C
K
N
G
Q
T
N
C
Y
Q
S
Y
S
T
M
S
I
T
D
C
R
E
T
G
S
S
K
Y
P
N
120
121
C
A
Y
K
T
T
Q
A
N
K
H
I
I
V
A
C
E
G
N
P
Y
V
P
V
H
F
D
A
S
V
150
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1152
Peptide:
SYSTMS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61823
UniProt Name:
RNAS1_BOVIN
Protein Name:
Ribonuclease (RNase A)
Position:
101-106
Literature
PMID:
20133726
Reference:
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.4
Area of the profile Above Threshold (AGGRESCAN):
0.57
Best Energy Score (PASTA 2.0):
-0.91
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1153 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1153
Peptide:
SYVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.98
Tango:
1.26
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
72.9
Area of the profile Above Threshold (AGGRESCAN):
4.77
Best Energy Score (PASTA 2.0):
-6.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1154 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
F
L
Y
Q
V
V
H
F
I
L
F
T
S
V
S
G
E
C
V
T
Q
L
L
K
D
T
C
F
E
G
G
D
I
T
T
V
F
T
P
S
A
K
Y
C
Q
V
V
C
T
Y
H
P
R
C
L
L
F
T
60
61
F
T
A
E
S
P
S
E
D
P
T
R
W
F
T
C
V
L
K
D
S
V
T
E
T
L
P
R
V
N
R
T
A
A
I
S
G
Y
S
F
K
Q
C
S
H
Q
I
S
A
C
N
K
D
I
Y
V
D
L
D
M
120
121
K
G
I
N
Y
N
S
S
V
A
K
S
A
Q
E
C
Q
E
R
C
T
D
D
V
H
C
H
F
F
T
Y
A
T
R
Q
F
P
S
L
E
H
R
N
I
C
L
L
K
H
T
Q
T
G
T
P
T
R
I
T
K
180
181
L
D
K
V
V
S
G
F
S
L
K
S
C
A
L
S
N
L
A
C
I
R
D
I
F
P
N
T
V
F
A
D
S
N
I
D
S
V
M
A
P
D
A
F
V
C
G
R
I
C
T
H
H
P
G
C
L
F
F
T
240
241
F
F
S
Q
E
W
P
K
E
S
Q
R
N
L
C
L
L
K
T
S
E
S
G
L
P
S
T
R
I
K
K
S
K
A
L
S
G
F
S
L
Q
S
C
R
H
S
I
P
V
F
C
H
S
S
F
Y
H
D
T
D
300
301
F
L
G
E
E
L
D
I
V
A
A
K
S
H
E
A
C
Q
K
L
C
T
N
A
V
R
C
Q
F
F
T
Y
T
P
A
Q
A
S
C
N
E
G
K
G
K
C
Y
L
K
L
S
S
N
G
S
P
T
K
I
L
360
361
H
G
R
G
G
I
S
G
Y
T
L
R
L
C
K
M
D
N
E
C
T
T
K
I
K
P
R
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
Q
R
H
L
C
G
G
S
I
420
421
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
A
E
S
G
Y
D
480
481
I
A
L
L
K
L
E
T
T
V
N
Y
T
D
S
Q
R
P
I
C
L
P
S
K
G
D
R
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
R
D
K
I
Q
N
T
L
Q
K
A
K
I
P
L
V
540
541
T
N
E
E
C
Q
K
R
Y
R
G
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
600
601
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
V
625
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1154
Peptide:
TAAHCF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P03951
UniProt Name:
FA11_HUMAN
Protein Name:
Coagulation factor XI (FXI)
Position:
428-433
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.9
Area of the profile Above Threshold (AGGRESCAN):
0.39
Best Energy Score (PASTA 2.0):
-0.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1155 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1155
Peptide:
TAELIT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.07
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.9
Area of the profile Above Threshold (AGGRESCAN):
0.94
Best Energy Score (PASTA 2.0):
-1.13
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1156 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
N
K
L
L
F
M
M
L
T
I
L
G
A
P
G
I
A
A
A
A
G
Y
D
L
A
N
S
E
Y
N
F
A
V
N
E
L
S
K
S
S
F
N
Q
A
A
I
I
G
Q
A
G
T
N
N
S
A
Q
L
60
61
R
Q
G
G
S
K
L
L
A
V
V
A
Q
E
G
S
S
N
R
A
K
I
D
Q
T
G
D
Y
N
L
A
Y
I
D
Q
A
G
S
A
N
D
A
S
I
S
Q
G
A
Y
G
N
T
A
M
I
I
Q
K
G
S
120
121
G
N
K
A
N
I
T
Q
Y
G
T
Q
K
T
A
I
V
V
Q
R
Q
S
Q
M
A
I
R
V
T
Q
R
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1156
Peptide:
TAMIIQ
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P0ABK7
UniProt Name:
CSGB_ECOLI
Protein Name:
Minor curlin subunit
Position:
112-117
Literature
PMID:
27245712
Reference:
J Struct Biol. 2016 Aug;195(2):179-189.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.33
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.5
Area of the profile Above Threshold (AGGRESCAN):
3.01
Best Energy Score (PASTA 2.0):
-3.7
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1157 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
G
F
Q
K
F
S
P
F
L
A
L
S
I
L
V
L
L
Q
A
G
S
L
H
A
A
P
F
R
S
A
L
E
S
S
P
A
D
P
A
T
L
S
E
D
E
A
R
L
L
L
A
A
L
V
Q
D
Y
V
Q
60
61
M
K
A
S
E
L
E
Q
E
Q
E
R
E
G
S
S
L
D
S
P
R
S
K
R
C
G
N
L
S
T
C
M
L
G
T
Y
T
Q
D
F
N
K
F
H
T
F
P
Q
T
A
I
G
V
G
A
P
G
K
K
R
120
121
D
M
S
S
D
L
E
R
D
H
R
P
H
V
S
M
P
Q
N
A
N
141
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1157
Peptide:
TAMLGT
Length:
6
Classification:
amyloid
Mutation(s):
C91A
Structure(s):
No structures
Protein Information
UniProt ID:
P01258
UniProt Name:
CALC_HUMAN
Protein Name:
Calcitonin; Katacalcin
Position:
90-95
Literature
PMID:
23395606
Reference:
FEBS Lett. 2013 Mar 18;587(6):569-74.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
16.9
Area of the profile Above Threshold (AGGRESCAN):
1.19
Best Energy Score (PASTA 2.0):
-0.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1158 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1158
Peptide:
TASNSS
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
129-134
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-58.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.06
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1159 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1159
Peptide:
TATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38T
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.22
Tango:
3.56
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.0
Area of the profile Above Threshold (AGGRESCAN):
2.63
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1160 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
F
L
Y
Q
V
V
H
F
I
L
F
T
S
V
S
G
E
C
V
T
Q
L
L
K
D
T
C
F
E
G
G
D
I
T
T
V
F
T
P
S
A
K
Y
C
Q
V
V
C
T
Y
H
P
R
C
L
L
F
T
60
61
F
T
A
E
S
P
S
E
D
P
T
R
W
F
T
C
V
L
K
D
S
V
T
E
T
L
P
R
V
N
R
T
A
A
I
S
G
Y
S
F
K
Q
C
S
H
Q
I
S
A
C
N
K
D
I
Y
V
D
L
D
M
120
121
K
G
I
N
Y
N
S
S
V
A
K
S
A
Q
E
C
Q
E
R
C
T
D
D
V
H
C
H
F
F
T
Y
A
T
R
Q
F
P
S
L
E
H
R
N
I
C
L
L
K
H
T
Q
T
G
T
P
T
R
I
T
K
180
181
L
D
K
V
V
S
G
F
S
L
K
S
C
A
L
S
N
L
A
C
I
R
D
I
F
P
N
T
V
F
A
D
S
N
I
D
S
V
M
A
P
D
A
F
V
C
G
R
I
C
T
H
H
P
G
C
L
F
F
T
240
241
F
F
S
Q
E
W
P
K
E
S
Q
R
N
L
C
L
L
K
T
S
E
S
G
L
P
S
T
R
I
K
K
S
K
A
L
S
G
F
S
L
Q
S
C
R
H
S
I
P
V
F
C
H
S
S
F
Y
H
D
T
D
300
301
F
L
G
E
E
L
D
I
V
A
A
K
S
H
E
A
C
Q
K
L
C
T
N
A
V
R
C
Q
F
F
T
Y
T
P
A
Q
A
S
C
N
E
G
K
G
K
C
Y
L
K
L
S
S
N
G
S
P
T
K
I
L
360
361
H
G
R
G
G
I
S
G
Y
T
L
R
L
C
K
M
D
N
E
C
T
T
K
I
K
P
R
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
Q
R
H
L
C
G
G
S
I
420
421
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
A
E
S
G
Y
D
480
481
I
A
L
L
K
L
E
T
T
V
N
Y
T
D
S
Q
R
P
I
C
L
P
S
K
G
D
R
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
R
D
K
I
Q
N
T
L
Q
K
A
K
I
P
L
V
540
541
T
N
E
E
C
Q
K
R
Y
R
G
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
600
601
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
V
625
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1160
Peptide:
TAVHCF
Length:
6
Classification:
Non-amyloid
Mutation(s):
A430V
Structure(s):
No structures
Protein Information
UniProt ID:
P03951
UniProt Name:
FA11_HUMAN
Protein Name:
Coagulation factor XI (FXI)
Position:
428-433
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.67
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
16.7
Area of the profile Above Threshold (AGGRESCAN):
1.58
Best Energy Score (PASTA 2.0):
-2.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1161 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
G
F
Q
K
F
S
P
F
L
A
L
S
I
L
V
L
L
Q
A
G
S
L
H
A
A
P
F
R
S
A
L
E
S
S
P
A
D
P
A
T
L
S
E
D
E
A
R
L
L
L
A
A
L
V
Q
D
Y
V
Q
60
61
M
K
A
S
E
L
E
Q
E
Q
E
R
E
G
S
R
I
I
A
Q
K
R
A
C
D
T
A
T
C
V
T
H
R
L
A
G
L
L
S
R
S
G
G
V
V
K
N
N
F
V
P
T
N
V
G
S
K
A
F
G
120
121
R
R
R
R
D
L
Q
A
128
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1161
Peptide:
TAVTHR
Length:
6
Classification:
amyloid
Mutation(s):
C89A
Structure(s):
No structures
Protein Information
UniProt ID:
P06881
UniProt Name:
CALCA_HUMAN
Protein Name:
Calcitonin gene-related peptide 1
Position:
88-93
Literature
PMID:
29501724
Reference:
J Struct Biol. 2018 Jul;203(1):27-36.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.41
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-17.6
Area of the profile Above Threshold (AGGRESCAN):
0.06
Best Energy Score (PASTA 2.0):
-2.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1162 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
S
Q
I
L
P
L
A
G
A
I
S
V
A
S
G
F
W
I
P
D
F
S
N
K
Q
N
S
N
S
Y
P
G
Q
Y
K
G
K
G
G
Y
Q
D
D
C
G
D
D
Y
K
K
G
Y
K
S
K
T
Y
60
61
S
K
V
K
P
I
T
S
T
D
C
T
T
P
I
Q
P
T
G
T
T
T
G
Y
T
K
D
V
V
E
S
T
S
Y
T
T
D
T
A
Y
T
T
T
V
I
T
V
T
K
C
D
G
G
S
C
S
H
T
A
V
120
121
T
T
G
V
T
I
I
T
V
T
T
N
D
V
I
T
E
Y
T
T
Y
C
P
L
T
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
180
181
E
S
T
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
240
241
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
A
S
T
E
T
A
S
S
T
P
V
E
S
T
V
I
V
P
S
T
T
V
I
T
V
S
S
C
Y
E
D
K
C
S
V
S
S
V
T
T
G
V
V
T
I
300
301
S
S
E
E
T
I
Y
T
T
Y
C
P
I
T
S
S
I
T
I
P
V
P
N
T
S
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
360
361
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
420
421
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
A
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
480
481
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
S
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
G
T
E
A
T
P
V
T
T
Q
P
540
541
V
S
V
L
S
T
S
Q
V
V
T
A
S
G
E
F
S
T
V
T
A
H
S
T
S
I
V
A
S
C
P
E
G
G
C
V
P
E
G
Q
Q
T
E
T
S
P
S
V
P
T
N
G
P
E
V
E
A
S
S
S
600
601
V
L
S
I
P
V
S
S
V
T
T
S
T
I
A
S
S
S
E
T
S
V
P
P
A
Q
V
S
T
F
E
G
S
G
S
A
L
K
K
P
Y
Y
G
L
A
V
A
A
L
V
Y
F
M
653
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1162
Peptide:
TAVTTG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
G1UBC2
UniProt Name:
G1UBC2_CANAL
Protein Name:
Cell wall adhesin EAP1
Position:
118-123
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.17
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.1
Area of the profile Above Threshold (AGGRESCAN):
0.4
Best Energy Score (PASTA 2.0):
-2.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1163 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
H
R
L
L
L
L
C
L
A
G
L
V
F
V
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
M
V
K
V
L
D
A
V
R
G
S
P
A
I
N
V
A
V
H
V
F
R
K
A
A
D
D
T
60
61
W
E
P
F
A
S
G
K
T
S
E
S
G
E
L
H
G
L
T
T
E
E
E
F
V
E
G
I
Y
K
V
E
I
D
T
K
S
Y
W
K
A
L
G
I
S
P
F
H
E
H
A
E
V
V
F
T
A
N
D
S
120
121
G
P
R
R
Y
T
I
A
A
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
P
K
E
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1163
Peptide:
TAVVTN
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02766
UniProt Name:
TTHY_HUMAN
Protein Name:
Transthyretin
Position:
139-144
Literature
PMID:
26459562
Reference:
J Biol Chem. 2015 Nov 27;290(48):28932-43.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.0
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
28.5
Area of the profile Above Threshold (AGGRESCAN):
1.98
Best Energy Score (PASTA 2.0):
-4.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1164 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1164
Peptide:
TAWYAE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.09
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.2
Area of the profile Above Threshold (AGGRESCAN):
0.81
Best Energy Score (PASTA 2.0):
-0.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1165 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
G
F
Q
K
F
S
P
F
L
A
L
S
I
L
V
L
L
Q
A
G
S
L
H
A
A
P
F
R
S
A
L
E
S
S
P
A
D
P
A
T
L
S
E
D
E
A
R
L
L
L
A
A
L
V
Q
D
Y
V
Q
60
61
M
K
A
S
E
L
E
Q
E
Q
E
R
E
G
S
S
L
D
S
P
R
S
K
R
C
G
N
L
S
T
C
M
L
G
T
Y
T
Q
D
F
N
K
F
H
T
F
P
Q
T
A
I
G
V
G
A
P
G
K
K
R
120
121
D
M
S
S
D
L
E
R
D
H
R
P
H
V
S
M
P
Q
N
A
N
141
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1165
Peptide:
TCMLGT
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01258
UniProt Name:
CALC_HUMAN
Protein Name:
Calcitonin; Katacalcin
Position:
90-95
Literature
PMID:
23395606
Reference:
FEBS Lett. 2013 Mar 18;587(6):569-74.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
25.5
Area of the profile Above Threshold (AGGRESCAN):
1.77
Best Energy Score (PASTA 2.0):
-1.09
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1166 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
G
F
Q
K
F
S
P
F
L
A
L
S
I
L
V
L
L
Q
A
G
S
L
H
A
A
P
F
R
S
A
L
E
S
S
P
A
D
P
A
T
L
S
E
D
E
A
R
L
L
L
A
A
L
V
Q
D
Y
V
Q
60
61
M
K
A
S
E
L
E
Q
E
Q
E
R
E
G
S
R
I
I
A
Q
K
R
A
C
D
T
A
T
C
V
T
H
R
L
A
G
L
L
S
R
S
G
G
V
V
K
N
N
F
V
P
T
N
V
G
S
K
A
F
G
120
121
R
R
R
R
D
L
Q
A
128
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1166
Peptide:
TCVTHR
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06881
UniProt Name:
CALCA_HUMAN
Protein Name:
Calcitonin gene-related peptide 1
Position:
88-93
Literature
PMID:
29501724
Reference:
J Struct Biol. 2018 Jul;203(1):27-36.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
0.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-9.1
Area of the profile Above Threshold (AGGRESCAN):
0.37
Best Energy Score (PASTA 2.0):
-2.95
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1167 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
M
P
H
R
Y
M
F
L
A
V
F
T
L
L
A
L
T
S
V
A
S
G
A
T
E
A
C
L
P
A
G
Q
R
K
S
G
M
N
I
N
F
Y
Q
Y
S
L
K
D
S
S
T
Y
S
N
A
A
Y
M
60
61
A
Y
G
Y
A
S
K
T
K
L
G
S
V
G
G
Q
T
D
I
S
I
D
Y
N
I
P
C
V
S
S
S
G
T
F
P
C
P
Q
E
D
S
Y
G
N
W
G
C
K
G
M
G
A
C
S
N
S
Q
G
I
A
120
121
Y
W
S
T
D
L
F
G
F
Y
T
T
P
T
N
V
T
L
E
M
T
G
Y
F
L
P
P
Q
T
G
S
Y
T
F
K
F
A
T
V
D
D
S
A
I
L
S
V
G
G
A
T
A
F
N
C
C
A
Q
Q
Q
180
181
P
P
I
T
S
T
N
F
T
I
D
G
I
K
P
W
G
G
S
L
P
P
N
I
E
G
T
V
Y
M
Y
A
G
Y
Y
Y
P
M
K
V
V
Y
S
N
A
V
S
W
G
T
L
P
I
S
V
T
L
P
D
G
240
241
T
T
V
S
D
D
F
E
G
Y
V
Y
S
F
D
D
D
L
S
Q
S
N
C
T
V
P
D
P
S
N
Y
A
V
S
T
T
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
300
301
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
T
A
S
T
I
I
T
T
T
E
P
W
N
S
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
V
R
T
D
E
T
I
I
V
I
R
T
P
360
361
T
T
A
T
T
A
I
T
T
T
E
P
W
N
S
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
420
421
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
480
481
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
I
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
540
541
T
T
A
T
T
A
M
T
T
P
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
I
T
T
T
E
P
W
N
S
600
601
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
I
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
660
661
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
I
T
T
V
T
G
T
T
G
L
P
T
D
E
T
I
I
V
I
R
T
P
720
721
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
780
781
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
V
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
I
T
G
T
840
841
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
I
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
900
901
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
H
V
T
G
T
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
960
961
T
F
T
S
T
S
T
E
V
T
T
I
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
1020
1021
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
V
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
S
T
V
T
G
T
N
G
L
P
T
D
E
T
V
I
V
V
K
T
P
1080
1081
T
T
A
I
S
S
S
L
S
S
S
S
S
G
Q
I
T
S
S
I
T
S
S
R
P
I
I
T
P
F
Y
P
S
N
G
T
S
V
I
S
S
S
V
I
S
S
S
V
T
S
S
L
F
T
S
S
P
V
I
S
1140
1141
S
S
V
I
S
S
S
T
T
T
S
T
S
I
F
S
E
S
S
K
S
S
V
I
P
T
S
S
S
T
S
G
S
S
E
S
E
T
S
S
A
G
S
V
S
S
S
S
F
I
S
S
E
S
S
K
S
P
T
Y
1200
1201
S
S
S
S
L
P
L
V
T
S
A
T
T
S
Q
E
T
A
S
S
L
P
P
A
T
T
T
K
T
S
E
Q
T
T
L
V
T
V
T
S
C
E
S
H
V
C
T
E
S
I
S
P
A
I
V
S
T
A
T
V
1260
1261
T
V
S
G
V
T
T
E
Y
T
T
W
C
P
I
S
T
T
E
T
T
K
Q
T
K
G
T
T
E
Q
T
T
E
T
T
K
Q
T
T
V
V
T
I
S
S
C
E
S
D
V
C
S
K
T
A
S
P
A
I
V
1320
1321
S
T
S
T
A
T
I
N
G
V
T
T
E
Y
T
T
W
C
P
I
S
T
T
E
S
R
Q
Q
T
T
L
V
T
V
T
S
C
E
S
G
V
C
S
E
T
A
S
P
A
I
V
S
T
A
T
A
T
V
N
D
1380
1381
V
V
T
V
Y
P
T
W
R
P
Q
T
A
N
E
E
S
V
S
S
K
M
N
S
A
T
G
E
T
T
T
N
T
L
A
A
E
T
T
T
N
T
V
A
A
E
T
I
T
N
T
G
A
A
E
T
K
T
V
V
1440
1441
T
S
S
L
S
R
S
N
H
A
E
T
Q
T
A
S
A
T
D
V
I
G
H
S
S
S
V
V
S
V
S
E
T
G
N
T
K
S
L
T
S
S
G
L
S
T
M
S
Q
Q
P
R
S
T
P
A
S
S
M
V
1500
1501
G
Y
S
T
A
S
L
E
I
S
T
Y
A
G
S
A
N
S
L
L
A
G
S
G
L
S
V
F
I
A
S
L
L
L
A
I
I
1537
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1167
Peptide:
TDETVI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32768
UniProt Name:
FLO1_YEAST
Protein Name:
Flocculation protein FLO1 (Flocculin-1)
Position:
305-310
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.1
Area of the profile Above Threshold (AGGRESCAN):
0.37
Best Energy Score (PASTA 2.0):
-1.44
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1168 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1168
Peptide:
TEEKKE
Length:
6
Classification:
Non-amyloid
Mutation(s):
T206K
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
202-207
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
0.0
NuAPRpred:
-0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-111.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.81
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1169 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1169
Peptide:
TEFTPT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
88-93
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.6
Area of the profile Above Threshold (AGGRESCAN):
0.02
Best Energy Score (PASTA 2.0):
-0.78
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1170 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1170
Peptide:
TFQINS
Length:
6
Classification:
Amyloid
Mutation(s):
I74T
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
Literature
PMID:
20133726
Reference:
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.7
Area of the profile Above Threshold (AGGRESCAN):
0.7
Best Energy Score (PASTA 2.0):
-1.51
Aggregate Orientation (PASTA 2.0):
Parallel
