Home
Links
APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Tutorial
Statistics
Download
Contact Us
Home
Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
help
Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
Enter the query text:
help
Select a class:
help
All
Amyloid
Non-Amyloid
Submit
Reset
Max. of 30 records would be displayed in a single page.
Patterns can be used in the search.
«
1
2
36
37
38
39
40
41
(current)
42
43
44
45
46
67
68
»
Displaying 1201 to 1230 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1201
TVIVIR
6
Non-amyloid
Flocculation protein FLO1 (Flocculin-1)
P32768
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1202
TVKQFG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1203
TVVSTT
6
Non-amyloid
Flocculin
E9P9G2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1204
TYQIIR
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1205
TYSFYC
6
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1206
TYVEYI
6
Amyloid
Phosphatidylinositol 3-kinase regulatory subunit alpha
P27986
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1207
VAFNIT
6
Amyloid
No
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
14691246
Waltz-DB 2.0, AmyLoad
P-1208
VAIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624A
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1209
VAMHVF
6
Non-amyloid
Transthyretin (ATTR) (Prealbumin) (TBPA)
P02766
V48M
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1210
VANFIT
6
Amyloid
No
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
14691246
Waltz-DB 2.0, AmyLoad
P-1211
VANNST
6
Non-amyloid
Transcriptional activator/repressor MOT3
P54785
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1212
VATTRT
6
Non-amyloid
Agglutinin-like protein 1 (Adhesin 1)
Q5A8T4
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1213
VATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38V
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1214
VAVHVF
6
Amyloid
Transthyretin (ATTR) (Prealbumin) (TBPA)
P02766
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1215
VAWLKM
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1216
VCIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624C
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1217
VDIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624D
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1218
VDQTAS
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1219
VDTKPA
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
G162D
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1220
VEALYL
6
Amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1221
VEDLKI
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1222
VEEPVK
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1223
VEIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624E
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1224
VFFFIG
6
Non-amyloid
Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE)
Q9UKU6
CPAD, WALTZ
P-1225
VFFINQ
6
Non-amyloid
Otoferlin (Fer-1-like protein 2)
Q9HC10
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1226
VFFNNT
6
Amyloid
ATP-binding cassette sub-family A member 12
Q86UK0
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1227
VFIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624F
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1228
VGFGNN
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1229
VGIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624G
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1230
VGQGSD
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
«
1
2
36
37
38
39
40
41
(current)
42
43
44
45
46
67
68
»
<
Entry: P-1201 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
M
P
H
R
Y
M
F
L
A
V
F
T
L
L
A
L
T
S
V
A
S
G
A
T
E
A
C
L
P
A
G
Q
R
K
S
G
M
N
I
N
F
Y
Q
Y
S
L
K
D
S
S
T
Y
S
N
A
A
Y
M
60
61
A
Y
G
Y
A
S
K
T
K
L
G
S
V
G
G
Q
T
D
I
S
I
D
Y
N
I
P
C
V
S
S
S
G
T
F
P
C
P
Q
E
D
S
Y
G
N
W
G
C
K
G
M
G
A
C
S
N
S
Q
G
I
A
120
121
Y
W
S
T
D
L
F
G
F
Y
T
T
P
T
N
V
T
L
E
M
T
G
Y
F
L
P
P
Q
T
G
S
Y
T
F
K
F
A
T
V
D
D
S
A
I
L
S
V
G
G
A
T
A
F
N
C
C
A
Q
Q
Q
180
181
P
P
I
T
S
T
N
F
T
I
D
G
I
K
P
W
G
G
S
L
P
P
N
I
E
G
T
V
Y
M
Y
A
G
Y
Y
Y
P
M
K
V
V
Y
S
N
A
V
S
W
G
T
L
P
I
S
V
T
L
P
D
G
240
241
T
T
V
S
D
D
F
E
G
Y
V
Y
S
F
D
D
D
L
S
Q
S
N
C
T
V
P
D
P
S
N
Y
A
V
S
T
T
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
300
301
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
T
A
S
T
I
I
T
T
T
E
P
W
N
S
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
V
R
T
D
E
T
I
I
V
I
R
T
P
360
361
T
T
A
T
T
A
I
T
T
T
E
P
W
N
S
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
420
421
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
L
T
T
V
T
G
T
480
481
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
I
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
540
541
T
T
A
T
T
A
M
T
T
P
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
I
T
T
T
E
P
W
N
S
600
601
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
I
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
660
661
N
G
L
P
T
D
E
T
I
I
V
I
R
T
P
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
I
T
T
V
T
G
T
T
G
L
P
T
D
E
T
I
I
V
I
R
T
P
720
721
T
T
A
T
T
A
M
T
T
T
Q
P
W
N
D
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
780
781
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
V
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
I
T
G
T
840
841
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
I
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
900
901
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
H
V
T
G
T
N
G
V
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
960
961
T
F
T
S
T
S
T
E
V
T
T
I
T
G
T
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
I
S
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
T
T
V
T
G
T
1020
1021
N
G
Q
P
T
D
E
T
V
I
V
I
R
T
P
T
S
E
G
L
V
T
T
T
T
E
P
W
T
G
T
F
T
S
T
S
T
E
M
S
T
V
T
G
T
N
G
L
P
T
D
E
T
V
I
V
V
K
T
P
1080
1081
T
T
A
I
S
S
S
L
S
S
S
S
S
G
Q
I
T
S
S
I
T
S
S
R
P
I
I
T
P
F
Y
P
S
N
G
T
S
V
I
S
S
S
V
I
S
S
S
V
T
S
S
L
F
T
S
S
P
V
I
S
1140
1141
S
S
V
I
S
S
S
T
T
T
S
T
S
I
F
S
E
S
S
K
S
S
V
I
P
T
S
S
S
T
S
G
S
S
E
S
E
T
S
S
A
G
S
V
S
S
S
S
F
I
S
S
E
S
S
K
S
P
T
Y
1200
1201
S
S
S
S
L
P
L
V
T
S
A
T
T
S
Q
E
T
A
S
S
L
P
P
A
T
T
T
K
T
S
E
Q
T
T
L
V
T
V
T
S
C
E
S
H
V
C
T
E
S
I
S
P
A
I
V
S
T
A
T
V
1260
1261
T
V
S
G
V
T
T
E
Y
T
T
W
C
P
I
S
T
T
E
T
T
K
Q
T
K
G
T
T
E
Q
T
T
E
T
T
K
Q
T
T
V
V
T
I
S
S
C
E
S
D
V
C
S
K
T
A
S
P
A
I
V
1320
1321
S
T
S
T
A
T
I
N
G
V
T
T
E
Y
T
T
W
C
P
I
S
T
T
E
S
R
Q
Q
T
T
L
V
T
V
T
S
C
E
S
G
V
C
S
E
T
A
S
P
A
I
V
S
T
A
T
A
T
V
N
D
1380
1381
V
V
T
V
Y
P
T
W
R
P
Q
T
A
N
E
E
S
V
S
S
K
M
N
S
A
T
G
E
T
T
T
N
T
L
A
A
E
T
T
T
N
T
V
A
A
E
T
I
T
N
T
G
A
A
E
T
K
T
V
V
1440
1441
T
S
S
L
S
R
S
N
H
A
E
T
Q
T
A
S
A
T
D
V
I
G
H
S
S
S
V
V
S
V
S
E
T
G
N
T
K
S
L
T
S
S
G
L
S
T
M
S
Q
Q
P
R
S
T
P
A
S
S
M
V
1500
1501
G
Y
S
T
A
S
L
E
I
S
T
Y
A
G
S
A
N
S
L
L
A
G
S
G
L
S
V
F
I
A
S
L
L
L
A
I
I
1537
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1201
Peptide:
TVIVIR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32768
UniProt Name:
FLO1_YEAST
Protein Name:
Flocculation protein FLO1 (Flocculin-1)
Position:
308-313
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.69
Tango:
9.55
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
81.8
Area of the profile Above Threshold (AGGRESCAN):
5.36
Best Energy Score (PASTA 2.0):
-8.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1202 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1202
Peptide:
TVKQFG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
114-119
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.6
Area of the profile Above Threshold (AGGRESCAN):
0.38
Best Energy Score (PASTA 2.0):
-1.42
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1203 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
R
P
F
P
F
A
Y
L
V
L
S
L
L
F
Y
S
A
L
G
F
P
T
A
L
V
P
R
G
S
S
E
G
T
S
C
N
S
I
V
N
G
C
P
N
L
D
F
N
W
H
M
N
Q
Q
N
I
M
Q
60
61
Y
T
L
D
V
T
S
V
S
W
V
Q
D
N
T
Y
Q
I
T
I
H
V
K
G
E
E
N
I
D
L
K
Y
L
S
S
L
K
I
I
G
V
T
G
P
K
D
T
V
Q
L
Y
G
Y
D
E
N
T
D
W
I
120
121
D
N
P
L
V
S
R
C
D
E
N
T
Y
L
I
D
N
P
T
D
F
T
A
T
F
E
V
Y
A
T
Q
D
V
N
S
C
Q
V
W
M
P
N
F
Q
I
Q
F
E
Y
L
Q
G
S
A
A
E
Y
A
C
S
180
181
W
E
W
G
T
T
S
F
Y
L
S
T
G
C
D
N
Y
D
N
Q
G
Y
S
Q
T
D
F
P
G
F
Y
W
N
I
D
C
D
N
N
C
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
240
241
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
300
301
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
360
361
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
420
421
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
480
481
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
A
P
S
S
S
T
T
E
S
S
S
A
P
540
541
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
600
601
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
660
661
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
720
721
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
780
781
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
V
P
T
P
S
S
S
T
T
E
S
S
840
841
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
900
901
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
S
K
Y
P
G
S
Q
T
E
T
S
V
S
S
T
T
960
961
E
T
T
I
V
P
T
T
T
T
T
S
V
T
T
P
S
T
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
I
T
T
T
V
P
C
S
T
S
P
S
E
T
A
S
1020
1021
E
S
T
T
T
S
P
T
T
P
V
T
T
V
V
S
T
T
V
V
T
T
E
Y
S
T
S
T
K
P
G
G
E
I
T
T
T
F
V
T
K
N
I
P
T
T
Y
L
T
T
I
A
P
T
P
S
V
T
T
V
1080
1081
T
N
F
T
P
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
V
T
T
T
V
P
C
S
T
G
T
G
E
Y
T
T
E
A
T
T
P
V
T
T
A
V
T
T
T
1140
1141
V
V
T
T
E
S
S
T
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
V
P
T
T
Y
V
T
T
L
A
P
S
A
P
V
T
P
A
T
S
A
V
P
T
T
I
T
T
T
E
C
S
A
A
T
N
1200
1201
A
A
G
E
T
T
S
V
C
S
A
K
T
I
V
S
S
A
S
A
G
E
N
T
T
P
V
T
T
A
I
P
T
T
V
V
T
T
E
S
S
V
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
I
P
1260
1261
T
T
Y
I
T
T
L
I
P
G
S
N
G
A
K
N
Y
E
T
V
A
T
A
T
N
P
I
S
I
K
T
T
S
Q
L
A
T
T
A
S
A
S
S
M
A
P
V
V
T
S
P
S
L
T
G
P
L
Q
S
A
1320
1321
S
G
S
A
V
A
T
Y
S
V
P
S
I
S
S
T
Y
Q
G
A
A
N
I
K
V
L
G
N
F
M
W
L
L
L
A
L
P
V
V
F
1360
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1203
Peptide:
TVVSTT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
E9P9G2
UniProt Name:
E9P9G2_YEASX
Protein Name:
Flocculin
Position:
1033-1038
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.06
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.9
Area of the profile Above Threshold (AGGRESCAN):
1.68
Best Energy Score (PASTA 2.0):
-3.58
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1204 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1204
Peptide:
TYQIIR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.28
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
19.5
Area of the profile Above Threshold (AGGRESCAN):
1.3
Best Energy Score (PASTA 2.0):
-3.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1205 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1205
Peptide:
TYSFYC
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
79-84
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.7
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.5
Area of the profile Above Threshold (AGGRESCAN):
3.0
Best Energy Score (PASTA 2.0):
-2.25
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1206 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
A
E
G
Y
Q
Y
R
A
L
Y
D
Y
K
K
E
R
E
E
D
I
D
L
H
L
G
D
I
L
T
V
N
K
G
S
L
V
A
L
G
F
S
D
G
Q
E
A
R
P
E
E
I
G
W
L
N
G
Y
N
60
61
E
T
T
G
E
R
G
D
F
P
G
T
Y
V
E
Y
I
G
R
K
K
I
S
P
P
T
P
K
P
R
P
P
R
P
L
P
V
A
P
G
S
S
K
T
E
A
D
V
E
Q
Q
A
L
T
L
P
D
L
A
E
120
121
Q
F
A
P
P
D
I
A
P
P
L
L
I
K
L
V
E
A
I
E
K
K
G
L
E
C
S
T
L
Y
R
T
Q
S
S
S
N
L
A
E
L
R
Q
L
L
D
C
D
T
P
S
V
D
L
E
M
I
D
V
H
180
181
V
L
A
D
A
F
K
R
Y
L
L
D
L
P
N
P
V
I
P
A
A
V
Y
S
E
M
I
S
L
A
P
E
V
Q
S
S
E
E
Y
I
Q
L
L
K
K
L
I
R
S
P
S
I
P
H
Q
Y
W
L
T
L
240
241
Q
Y
L
L
K
H
F
F
K
L
S
Q
T
S
S
K
N
L
L
N
A
R
V
L
S
E
I
F
S
P
M
L
F
R
F
S
A
A
S
S
D
N
T
E
N
L
I
K
V
I
E
I
L
I
S
T
E
W
N
E
300
301
R
Q
P
A
P
A
L
P
P
K
P
P
K
P
T
T
V
A
N
N
G
M
N
N
N
M
S
L
Q
D
A
E
W
Y
W
G
D
I
S
R
E
E
V
N
E
K
L
R
D
T
A
D
G
T
F
L
V
R
D
A
360
361
S
T
K
M
H
G
D
Y
T
L
T
L
R
K
G
G
N
N
K
L
I
K
I
F
H
R
D
G
K
Y
G
F
S
D
P
L
T
F
S
S
V
V
E
L
I
N
H
Y
R
N
E
S
L
A
Q
Y
N
P
K
L
420
421
D
V
K
L
L
Y
P
V
S
K
Y
Q
Q
D
Q
V
V
K
E
D
N
I
E
A
V
G
K
K
L
H
E
Y
N
T
Q
F
Q
E
K
S
R
E
Y
D
R
L
Y
E
E
Y
T
R
T
S
Q
E
I
Q
M
K
480
481
R
T
A
I
E
A
F
N
E
T
I
K
I
F
E
E
Q
C
Q
T
Q
E
R
Y
S
K
E
Y
I
E
K
F
K
R
E
G
N
E
K
E
I
Q
R
I
M
H
N
Y
D
K
L
K
S
R
I
S
E
I
I
D
540
541
S
R
R
R
L
E
E
D
L
K
K
Q
A
A
E
Y
R
E
I
D
K
R
M
N
S
I
K
P
D
L
I
Q
L
R
K
T
R
D
Q
Y
L
M
W
L
T
Q
K
G
V
R
Q
K
K
L
N
E
W
L
G
N
600
601
E
N
T
E
D
Q
Y
S
L
V
E
D
D
E
D
L
P
H
H
D
E
K
T
W
N
V
G
S
S
N
R
N
K
A
E
N
L
L
R
G
K
R
D
G
T
F
L
V
R
E
S
S
K
Q
G
C
Y
A
C
S
660
661
V
V
V
D
G
E
V
K
H
C
V
I
N
K
T
A
T
G
Y
G
F
A
E
P
Y
N
L
Y
S
S
L
K
E
L
V
L
H
Y
Q
H
T
S
L
V
Q
H
N
D
S
L
N
V
T
L
A
Y
P
V
Y
A
720
721
Q
Q
R
R
724
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1206
Peptide:
TYVEYI
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P27986
UniProt Name:
P85A_HUMAN
Protein Name:
Phosphatidylinositol 3-kinase regulatory subunit alpha
Position:
72-77
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.76
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.1
Area of the profile Above Threshold (AGGRESCAN):
2.24
Best Energy Score (PASTA 2.0):
-2.4
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1207 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1207
Peptide:
VAFNIT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
14691246
Reference:
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
29.1
Area of the profile Above Threshold (AGGRESCAN):
1.92
Best Energy Score (PASTA 2.0):
-4.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1208 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1208
Peptide:
VAIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624A
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.68
Tango:
9.54
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
71.9
Area of the profile Above Threshold (AGGRESCAN):
4.78
Best Energy Score (PASTA 2.0):
-5.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1209 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
H
R
L
L
L
L
C
L
A
G
L
V
F
V
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
M
V
K
V
L
D
A
V
R
G
S
P
A
I
N
V
A
V
H
V
F
R
K
A
A
D
D
T
60
61
W
E
P
F
A
S
G
K
T
S
E
S
G
E
L
H
G
L
T
T
E
E
E
F
V
E
G
I
Y
K
V
E
I
D
T
K
S
Y
W
K
A
L
G
I
S
P
F
H
E
H
A
E
V
V
F
T
A
N
D
S
120
121
G
P
R
R
Y
T
I
A
A
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
P
K
E
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1209
Peptide:
VAMHVF
Length:
6
Classification:
Non-amyloid
Mutation(s):
V48M
Structure(s):
No structures
Protein Information
UniProt ID:
P02766
UniProt Name:
TTHY_HUMAN
Protein Name:
Transthyretin (ATTR) (Prealbumin) (TBPA)
Position:
48-53
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.64
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.7
Area of the profile Above Threshold (AGGRESCAN):
2.18
Best Energy Score (PASTA 2.0):
-4.49
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1210 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1210
Peptide:
VANFIT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
14691246
Reference:
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
29.1
Area of the profile Above Threshold (AGGRESCAN):
1.92
Best Energy Score (PASTA 2.0):
-4.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1211 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
A
D
H
H
L
Q
Q
Q
Q
Q
Q
R
Q
Q
H
Q
Q
Q
Q
H
Q
Q
Q
Q
H
Q
H
Q
H
Q
Q
Q
Q
H
T
I
L
Q
N
V
S
N
T
N
N
I
G
S
D
S
L
A
S
Q
P
F
N
T
60
61
T
T
V
S
S
N
K
D
D
V
M
V
N
S
G
A
R
E
L
P
M
P
L
H
Q
Q
Q
Y
I
Y
P
Y
Y
Q
Y
T
S
N
N
S
N
N
N
N
V
T
A
G
N
N
M
S
A
S
P
I
V
H
N
N
120
121
S
N
N
S
N
N
S
N
I
S
A
S
D
Y
T
V
A
N
N
S
T
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
H
P
N
Q
F
T
A
A
A
N
M
N
S
N
A
A
A
A
A
Y
Y
S
180
181
F
P
T
A
N
M
P
I
P
Q
Q
D
Q
Q
Y
M
F
N
P
A
S
Y
I
S
H
Y
Y
S
A
V
N
S
N
N
N
G
N
N
A
A
N
N
G
S
N
N
S
S
H
S
A
P
A
P
A
P
G
P
P
H
240
241
H
H
H
H
H
S
N
T
H
N
N
L
N
N
G
G
A
V
N
T
N
N
A
P
Q
H
H
P
T
I
I
T
D
Q
F
Q
F
Q
L
Q
Q
N
P
S
P
N
L
N
L
N
I
N
P
A
Q
P
L
H
L
P
300
301
P
G
W
K
I
N
T
M
P
Q
P
R
P
T
T
A
P
N
H
P
P
A
P
V
P
S
S
N
P
V
A
S
N
L
V
P
A
P
S
S
D
H
K
Y
I
H
Q
C
Q
F
C
E
K
S
F
K
R
K
S
W
360
361
L
K
R
H
L
L
S
H
S
Q
Q
R
H
F
L
C
P
W
C
L
S
R
Q
K
R
K
D
N
L
L
Q
H
M
K
L
K
H
T
N
Y
L
L
D
E
L
K
K
N
N
I
I
F
N
Y
N
N
S
S
S
S
420
421
N
N
N
N
D
N
N
N
N
N
N
S
N
S
A
S
G
S
G
G
A
G
A
A
A
A
A
A
T
A
P
E
N
E
D
G
N
G
Y
D
T
N
I
K
T
L
I
N
D
G
V
L
N
K
D
D
V
K
R
V
480
481
L
N
N
L
I
V
S
H
N
K
490
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1211
Peptide:
VANNST
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P54785
UniProt Name:
MOT3_YEAST
Protein Name:
Transcriptional activator/repressor MOT3
Position:
136-141
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.31
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1212 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
Q
Q
F
T
L
L
F
L
Y
L
S
I
A
S
A
K
T
I
T
G
V
F
D
S
F
N
S
L
T
W
S
N
A
A
N
Y
A
F
K
G
P
G
Y
P
T
W
N
A
V
L
G
W
S
L
D
G
T
S
60
61
A
N
P
G
D
T
F
T
L
N
M
P
C
V
F
K
Y
T
T
S
Q
T
S
V
D
L
T
A
D
G
V
K
Y
A
T
C
Q
F
Y
S
G
E
E
F
T
T
F
S
T
L
T
C
T
V
N
D
A
L
K
S
120
121
S
I
K
A
F
G
T
V
T
L
P
I
A
F
N
V
G
G
T
G
S
S
T
D
L
E
D
S
K
C
F
T
A
G
T
N
T
V
T
F
N
D
G
D
K
D
I
S
I
D
V
E
F
E
K
S
T
V
D
P
180
181
S
G
Y
L
Y
A
S
R
V
M
P
S
L
N
K
V
T
T
L
F
V
A
P
Q
C
E
N
G
Y
T
S
G
T
M
G
F
S
S
S
N
G
D
V
A
I
D
C
S
N
I
H
I
G
I
T
K
G
L
N
D
240
241
W
N
Y
P
V
S
S
E
S
F
S
Y
T
K
T
C
T
S
N
G
I
Q
I
K
Y
Q
N
V
P
A
G
Y
R
P
F
I
D
A
Y
I
S
A
T
D
V
N
Q
Y
T
L
A
Y
T
N
D
Y
T
C
A
G
300
301
S
R
S
Q
S
K
P
F
T
L
R
W
T
G
Y
K
N
S
D
A
G
S
N
G
I
V
I
V
A
T
T
R
T
V
T
D
S
T
T
A
V
T
T
L
P
F
N
P
S
V
D
K
T
K
T
I
E
I
L
Q
360
361
P
I
P
T
T
T
I
T
T
S
Y
V
G
V
T
T
S
Y
S
T
K
T
A
P
I
G
E
T
A
T
V
I
V
D
V
P
Y
H
T
T
T
T
V
T
S
E
W
T
G
T
I
T
T
T
T
T
R
T
N
P
420
421
T
D
S
I
D
T
V
V
V
Q
V
P
S
P
N
P
T
V
S
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
480
481
S
Q
S
F
A
T
T
T
T
V
T
A
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
540
541
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
I
T
A
600
601
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
660
661
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
720
721
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
F
A
T
T
T
T
V
T
A
780
781
P
P
G
G
T
D
T
V
I
I
Y
E
S
M
S
S
S
K
I
S
T
S
S
N
D
I
T
S
I
I
P
S
F
S
R
P
H
Y
V
N
S
T
T
S
D
L
S
T
F
E
S
S
S
M
N
T
P
T
S
I
840
841
S
S
D
G
M
L
L
S
S
T
T
L
V
T
E
S
E
T
T
T
E
S
I
C
S
D
G
K
E
C
S
R
L
S
S
S
S
G
I
V
T
N
P
D
S
N
E
S
S
I
V
T
S
T
V
P
T
A
S
T
900
901
M
S
D
S
L
S
S
T
D
G
I
S
A
T
S
S
D
N
V
S
K
S
G
V
S
V
T
T
E
T
S
V
T
T
I
Q
T
T
P
N
P
L
S
S
S
V
T
S
L
T
Q
L
S
S
I
P
S
V
S
E
960
961
S
E
S
K
V
T
F
T
S
N
G
D
N
Q
S
G
T
H
D
S
Q
S
T
S
T
E
I
E
I
V
T
T
S
S
T
K
V
L
P
P
V
V
S
S
N
T
D
L
T
S
E
P
T
N
T
R
E
Q
P
T
1020
1021
T
L
S
T
T
S
N
S
I
T
E
D
I
T
T
S
Q
P
T
G
D
N
G
D
N
T
S
S
T
N
P
V
P
T
V
A
T
S
T
L
A
S
A
S
E
E
D
N
K
S
G
S
H
E
S
A
S
T
S
L
1080
1081
K
P
S
M
G
E
N
S
G
L
T
T
S
T
E
I
E
A
T
T
T
S
P
T
E
A
P
S
P
A
V
S
S
G
T
D
V
T
T
E
P
T
D
T
R
E
Q
P
T
T
L
S
T
T
S
K
T
N
S
E
1140
1141
S
V
A
T
T
Q
A
T
N
E
N
G
G
K
S
P
S
T
D
L
T
S
S
L
T
T
G
T
S
A
S
T
S
A
N
S
E
L
V
T
S
G
S
V
T
G
G
A
V
A
S
A
S
N
D
Q
S
H
S
T
1200
1201
S
V
T
N
S
N
S
I
V
S
N
T
P
Q
T
T
L
S
Q
Q
V
T
S
S
S
P
S
T
N
T
F
I
A
S
T
Y
D
G
S
G
S
I
I
Q
H
S
T
W
L
Y
G
L
I
T
L
L
S
L
F
I
1260
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1212
Peptide:
VATTRT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q5A8T4
UniProt Name:
ALS1_CANAL
Protein Name:
Agglutinin-like protein 1 (Adhesin 1)
Position:
328-333
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-27.1
Area of the profile Above Threshold (AGGRESCAN):
0.02
Best Energy Score (PASTA 2.0):
-1.85
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1213 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1213
Peptide:
VATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38V
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.82
Tango:
13.28
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
57.5
Area of the profile Above Threshold (AGGRESCAN):
3.72
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1214 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
H
R
L
L
L
L
C
L
A
G
L
V
F
V
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
M
V
K
V
L
D
A
V
R
G
S
P
A
I
N
V
A
V
H
V
F
R
K
A
A
D
D
T
60
61
W
E
P
F
A
S
G
K
T
S
E
S
G
E
L
H
G
L
T
T
E
E
E
F
V
E
G
I
Y
K
V
E
I
D
T
K
S
Y
W
K
A
L
G
I
S
P
F
H
E
H
A
E
V
V
F
T
A
N
D
S
120
121
G
P
R
R
Y
T
I
A
A
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
P
K
E
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1214
Peptide:
VAVHVF
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02766
UniProt Name:
TTHY_HUMAN
Protein Name:
Transthyretin (ATTR) (Prealbumin) (TBPA)
Position:
48-53
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.98
Tango:
4.87
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
47.4
Area of the profile Above Threshold (AGGRESCAN):
3.02
Best Energy Score (PASTA 2.0):
-6.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1215 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1215
Peptide:
VAWLKM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
42.4
Area of the profile Above Threshold (AGGRESCAN):
2.91
Best Energy Score (PASTA 2.0):
-3.16
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1216 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1216
Peptide:
VCIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624C
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
1.0
Tango:
15.8
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
80.4
Area of the profile Above Threshold (AGGRESCAN):
5.35
Best Energy Score (PASTA 2.0):
-6.49
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1217 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1217
Peptide:
VDIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624D
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
0.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
47.9
Area of the profile Above Threshold (AGGRESCAN):
3.16
Best Energy Score (PASTA 2.0):
-4.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1218 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1218
Peptide:
VDQTAS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
126-131
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-57.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.6
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1219 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1219
Peptide:
VDTKPA
Length:
6
Classification:
Non-amyloid
Mutation(s):
G162D
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
161-166
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-0.6
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-53.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.74
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1220 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1220
Peptide:
VEALYL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
2OMQ
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
36-41
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.83
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.2
Area of the profile Above Threshold (AGGRESCAN):
2.23
Best Energy Score (PASTA 2.0):
-1.45
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1221 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1221
Peptide:
VEDLKI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
215-220
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
0.08
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.1
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1222 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1222
Peptide:
VEEPVK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
189-194
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-43.9
Area of the profile Above Threshold (AGGRESCAN):
0.03
Best Energy Score (PASTA 2.0):
1.32
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1223 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1223
Peptide:
VEIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624E
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
53.5
Area of the profile Above Threshold (AGGRESCAN):
3.54
Best Energy Score (PASTA 2.0):
-3.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1224 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1224
Peptide:
VFFFIG
Length:
6
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q9UKU6
UniProt Name:
TRHDE_HUMAN
Protein Name:
Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE)
Position:
Literature
PMID:
Reference:
source:
CPAD, WALTZ
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.01
Tango:
139.27
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
110.4
Area of the profile Above Threshold (AGGRESCAN):
7.28
Best Energy Score (PASTA 2.0):
-6.64
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1225 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
L
I
H
L
K
T
V
S
E
L
R
G
R
G
D
R
I
A
K
V
T
F
R
G
Q
S
F
Y
S
R
V
L
E
N
C
E
D
V
A
D
F
D
E
T
F
R
W
P
V
A
S
S
I
D
R
N
E
60
61
M
L
E
I
Q
V
F
N
Y
S
K
V
F
S
N
K
L
I
G
T
F
R
M
V
L
Q
K
V
V
E
E
S
H
V
E
V
T
D
T
L
I
D
D
N
N
A
I
I
K
T
S
L
C
V
E
V
R
Y
Q
A
120
121
T
D
G
T
V
G
S
W
D
D
G
D
F
L
G
D
E
S
L
Q
E
E
E
K
D
S
Q
E
T
D
G
L
L
P
G
S
R
P
S
S
R
P
P
G
E
K
S
F
R
R
A
G
R
S
V
F
S
A
M
K
180
181
L
G
K
N
R
S
H
K
E
E
P
Q
R
P
D
E
P
A
V
L
E
M
E
D
L
D
H
L
A
I
R
L
G
D
G
L
D
P
D
S
V
S
L
A
S
V
T
A
L
T
T
N
V
S
N
K
R
S
K
P
240
241
D
I
K
M
E
P
S
A
G
R
P
M
D
Y
Q
V
S
I
T
V
I
E
A
R
Q
L
V
G
L
N
M
D
P
V
V
C
V
E
V
G
D
D
K
K
Y
T
S
M
K
E
S
T
N
C
P
Y
Y
N
E
Y
300
301
F
V
F
D
F
H
V
S
P
D
V
M
F
D
K
I
I
K
I
S
V
I
H
S
K
N
L
L
R
S
G
T
L
V
G
S
F
K
M
D
V
G
T
V
Y
S
Q
P
E
H
Q
F
H
H
K
W
A
I
L
S
360
361
D
P
D
D
I
S
S
G
L
K
G
Y
V
K
C
D
V
A
V
V
G
K
G
D
N
I
K
T
P
H
K
A
N
E
T
D
E
D
D
I
E
G
N
L
L
L
P
E
G
V
P
P
E
R
Q
W
A
R
F
Y
420
421
V
K
I
Y
R
A
E
G
L
P
R
M
N
T
S
L
M
A
N
V
K
K
A
F
I
G
E
N
K
D
L
V
D
P
Y
V
Q
V
F
F
A
G
Q
K
G
K
T
S
V
Q
K
S
S
Y
E
P
L
W
N
E
480
481
Q
V
V
F
T
D
L
F
P
P
L
C
K
R
M
K
V
Q
I
R
D
S
D
K
V
N
D
V
A
I
G
T
H
F
I
D
L
R
K
I
S
N
D
G
D
K
G
F
L
P
T
L
G
P
A
W
V
N
M
Y
540
541
G
S
T
R
N
Y
T
L
L
D
E
H
Q
D
L
N
E
G
L
G
E
G
V
S
F
R
A
R
L
L
L
G
L
A
V
E
I
V
D
T
S
N
P
E
L
T
S
S
T
E
V
Q
V
E
Q
A
T
P
I
S
600
601
E
S
C
A
G
K
M
E
E
F
F
L
F
G
A
F
L
E
A
S
M
I
D
R
R
N
G
D
K
P
I
T
F
E
V
T
I
G
N
Y
G
N
E
V
D
G
L
S
R
P
Q
R
P
R
P
R
K
E
P
G
660
661
D
E
E
E
V
D
L
I
Q
N
A
S
D
D
E
A
G
D
A
G
D
L
A
S
V
S
S
T
P
P
M
R
P
Q
V
T
D
R
N
Y
F
H
L
P
Y
L
E
R
K
P
C
I
Y
I
K
S
W
W
P
D
720
721
Q
R
R
R
L
Y
N
A
N
I
M
D
H
I
A
D
K
L
E
E
G
L
N
D
I
Q
E
M
I
K
T
E
K
S
Y
P
E
R
R
L
R
G
V
L
E
E
L
S
C
G
C
C
R
F
L
S
L
A
D
K
780
781
D
Q
G
H
S
S
R
T
R
L
D
R
E
R
L
K
S
C
M
R
E
L
E
N
M
G
Q
Q
A
R
M
L
R
A
Q
V
K
R
H
T
V
R
D
K
L
R
L
C
Q
N
F
L
Q
K
L
R
F
L
A
D
840
841
E
P
Q
H
S
I
P
D
I
F
I
W
M
M
S
N
N
K
R
V
A
Y
A
R
V
P
S
K
D
L
L
F
S
I
V
E
E
E
T
G
K
D
C
A
K
V
K
T
L
F
L
K
L
P
G
K
R
G
F
G
900
901
S
A
G
W
T
V
Q
A
K
V
E
L
Y
L
W
L
G
L
S
K
Q
R
K
E
F
L
C
G
L
P
C
G
F
Q
E
V
K
A
A
Q
G
L
G
L
H
A
F
P
P
V
S
L
V
Y
T
K
K
Q
A
F
960
961
Q
L
R
A
H
M
Y
Q
A
R
S
L
F
A
A
D
S
S
G
L
S
D
P
F
A
R
V
F
F
I
N
Q
S
Q
C
T
E
V
L
N
E
T
L
C
P
T
W
D
Q
M
L
V
F
D
N
L
E
L
Y
G
1020
1021
E
A
H
E
L
R
D
D
P
P
I
I
V
I
E
I
Y
D
Q
D
S
M
G
K
A
D
F
M
G
R
T
F
A
K
P
L
V
K
M
A
D
E
A
Y
C
P
P
R
F
P
P
Q
L
E
Y
Y
Q
I
Y
R
1080
1081
G
N
A
T
A
G
D
L
L
A
A
F
E
L
L
Q
I
G
P
A
G
K
A
D
L
P
P
I
N
G
P
V
D
V
D
R
G
P
I
M
P
V
P
M
G
I
R
P
V
L
S
K
Y
R
V
E
V
L
F
W
1140
1141
G
L
R
D
L
K
R
V
N
L
A
Q
V
D
R
P
R
V
D
I
E
C
A
G
K
G
V
Q
S
S
L
I
H
N
Y
K
K
N
P
N
F
N
T
L
V
K
W
F
E
V
D
L
P
E
N
E
L
L
H
P
1200
1201
P
L
N
I
R
V
V
D
C
R
A
F
G
R
Y
T
L
V
G
S
H
A
V
S
S
L
R
R
F
I
Y
R
P
P
D
R
S
A
P
S
W
N
T
T
V
R
L
L
R
R
C
R
V
L
C
N
G
G
S
S
1260
1261
S
H
S
T
G
E
V
V
V
T
M
E
P
E
V
P
I
K
K
L
E
T
M
V
K
L
D
A
T
S
E
A
V
V
K
V
D
V
A
E
E
E
K
E
K
K
K
K
K
K
G
T
A
E
E
P
E
E
E
E
1320
1321
P
D
E
S
M
L
D
W
W
S
K
Y
F
A
S
I
D
T
M
K
E
Q
L
R
Q
Q
E
P
S
G
I
D
L
E
E
K
E
E
V
D
N
T
E
G
L
K
G
S
M
K
G
K
E
K
A
R
A
A
K
E
1380
1381
E
K
K
K
K
T
Q
S
S
G
S
G
Q
G
S
E
A
P
E
K
K
K
P
K
I
D
E
L
K
V
Y
P
K
E
L
E
S
E
F
D
N
F
E
D
W
L
H
T
F
N
L
L
R
G
K
T
G
D
D
E
1440
1441
D
G
S
T
E
E
E
R
I
V
G
R
F
K
G
S
L
C
V
Y
K
V
P
L
P
E
D
V
S
R
E
A
G
Y
D
S
T
Y
G
M
F
Q
G
I
P
S
N
D
P
I
N
V
L
V
R
V
Y
V
V
R
1500
1501
A
T
D
L
H
P
A
D
I
N
G
K
A
D
P
Y
I
A
I
R
L
G
K
T
D
I
R
D
K
E
N
Y
I
S
K
Q
L
N
P
V
F
G
K
S
F
D
I
E
A
S
F
P
M
E
S
M
L
T
V
A
1560
1561
V
Y
D
W
D
L
V
G
T
D
D
L
I
G
E
T
K
I
D
L
E
N
R
F
Y
S
K
H
R
A
T
C
G
I
A
Q
T
Y
S
T
H
G
Y
N
I
W
R
D
P
M
K
P
S
Q
I
L
T
R
L
C
1620
1621
K
D
G
K
V
D
G
P
H
F
G
P
P
G
R
V
K
V
A
N
R
V
F
T
G
P
S
E
I
E
D
E
N
G
Q
R
K
P
T
D
E
H
V
A
L
L
A
L
R
H
W
E
D
I
P
R
A
G
C
R
1680
1681
L
V
P
E
H
V
E
T
R
P
L
L
N
P
D
K
P
G
I
E
Q
G
R
L
E
L
W
V
D
M
F
P
M
D
M
P
A
P
G
T
P
L
D
I
S
P
R
K
P
K
K
Y
E
L
R
V
I
I
W
N
1740
1741
T
D
E
V
V
L
E
D
D
D
F
F
T
G
E
K
S
S
D
I
F
V
R
G
W
L
K
G
Q
Q
E
D
K
Q
D
T
D
V
H
Y
H
S
L
T
G
E
G
N
F
N
W
R
Y
L
F
P
F
D
Y
L
1800
1801
A
A
E
E
K
I
V
I
S
K
K
E
S
M
F
S
W
D
E
T
E
Y
K
I
P
A
R
L
T
L
Q
I
W
D
A
D
H
F
S
A
D
D
F
L
G
A
I
E
L
D
L
N
R
F
P
R
G
A
K
T
1860
1861
A
K
Q
C
T
M
E
M
A
T
G
E
V
D
V
P
L
V
S
I
F
K
Q
K
R
V
K
G
W
W
P
L
L
A
R
N
E
N
D
E
F
E
L
T
G
K
V
E
A
E
L
H
L
L
T
A
E
E
A
E
1920
1921
K
N
P
V
G
L
A
R
N
E
P
D
P
L
E
K
P
N
R
P
D
T
S
F
I
W
F
L
N
P
L
K
S
A
R
Y
F
L
W
H
T
Y
R
W
L
L
L
K
L
L
L
L
L
L
L
L
L
L
L
A
1980
1981
L
F
L
Y
S
V
P
G
Y
L
V
K
K
I
L
G
A
1997
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1225
Peptide:
VFFINQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q9HC10
UniProt Name:
OTOF_HUMAN
Protein Name:
Otoferlin (Fer-1-like protein 2)
Position:
987-992
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.9
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
63.1
Area of the profile Above Threshold (AGGRESCAN):
4.45
Best Energy Score (PASTA 2.0):
-5.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1226 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
L
F
H
Q
L
Q
I
L
V
W
K
N
W
L
G
V
K
R
Q
P
L
W
T
L
V
L
I
L
W
P
V
I
I
F
I
I
L
A
I
T
R
T
K
F
P
P
T
A
K
P
T
C
Y
L
A
P
R
60
61
N
L
P
S
T
G
F
F
P
F
L
Q
T
L
L
C
D
T
D
S
K
C
K
D
T
P
Y
G
P
Q
D
L
L
R
R
K
G
I
D
D
A
L
F
K
D
S
E
I
L
R
K
S
S
N
L
D
K
D
S
S
120
121
L
S
F
Q
S
T
Q
V
P
E
R
R
H
A
S
L
A
T
V
F
P
S
P
S
S
D
L
E
I
P
G
T
Y
T
F
N
G
S
Q
V
L
A
R
I
L
G
L
E
K
L
L
K
Q
N
S
T
S
E
D
I
180
181
R
R
E
L
C
D
S
Y
S
G
Y
I
V
D
D
A
F
S
W
T
F
L
G
R
N
V
F
N
K
F
C
L
S
N
M
T
L
L
E
S
S
L
Q
E
L
N
K
Q
F
S
Q
L
S
S
D
P
N
N
Q
K
240
241
I
V
F
Q
E
I
V
R
M
L
S
F
F
S
Q
V
Q
E
Q
K
A
V
W
Q
L
L
S
S
F
P
N
V
F
Q
N
D
T
S
L
S
N
L
F
D
V
L
R
K
A
N
S
V
L
L
V
V
Q
K
V
Y
300
301
P
R
F
A
T
N
E
G
F
R
T
L
Q
K
S
V
K
H
L
L
Y
T
L
D
S
P
A
Q
G
D
S
D
N
I
T
H
V
W
N
E
D
D
G
Q
T
L
S
P
S
S
L
A
A
Q
L
L
I
L
E
N
360
361
F
E
D
A
L
L
N
I
S
A
N
S
P
Y
I
P
Y
L
A
C
V
R
N
V
T
D
S
L
A
R
G
S
P
E
N
L
R
L
L
Q
S
T
I
R
F
K
K
S
F
L
R
N
G
S
Y
E
D
Y
F
P
420
421
P
V
P
E
V
L
K
S
K
L
S
Q
L
R
N
L
T
E
L
L
C
E
S
E
T
F
S
L
I
E
K
S
C
Q
L
S
D
M
S
F
G
S
L
C
E
E
S
E
F
D
L
Q
L
L
E
A
A
E
L
G
480
481
T
E
I
A
A
S
L
L
Y
H
D
N
V
I
S
K
K
V
R
D
L
L
T
G
D
P
S
K
I
N
L
N
M
D
Q
F
L
E
Q
A
L
Q
M
N
Y
L
E
N
I
T
Q
L
I
P
I
I
E
A
M
L
540
541
H
V
N
N
S
A
D
A
S
E
K
P
G
Q
L
L
E
M
F
K
N
V
E
E
L
K
E
D
L
R
R
T
T
G
M
S
N
R
T
I
D
K
L
L
A
I
P
I
P
D
N
R
A
E
I
I
S
Q
V
F
600
601
W
L
H
S
C
D
T
N
I
T
T
P
K
L
E
D
A
M
K
E
F
C
N
L
S
L
S
E
R
S
R
Q
S
Y
L
I
G
L
T
L
L
H
Y
L
N
I
Y
N
F
T
Y
K
V
F
F
P
R
K
D
Q
660
661
K
P
V
E
K
M
M
E
L
F
I
R
L
K
E
I
L
N
Q
M
A
S
G
T
H
P
L
L
D
K
M
R
S
L
K
Q
M
H
L
P
R
S
V
P
L
T
Q
A
M
Y
R
S
N
R
M
N
T
P
Q
G
720
721
S
F
S
T
I
S
Q
A
L
C
S
Q
G
I
T
T
E
Y
L
T
A
M
L
P
S
S
Q
R
P
K
G
N
H
T
K
D
F
L
T
Y
K
L
T
K
E
Q
I
A
S
K
Y
G
I
P
I
N
S
T
P
F
780
781
C
F
S
L
Y
K
D
I
I
N
M
P
A
G
P
V
I
W
A
F
L
K
P
M
L
L
G
R
I
L
Y
A
P
Y
N
P
V
T
K
A
I
M
E
K
S
N
V
T
L
R
Q
L
A
E
L
R
E
K
S
Q
840
841
E
W
M
D
K
S
P
L
F
M
N
S
F
H
L
L
N
Q
A
I
P
M
L
Q
N
T
L
R
N
P
F
V
Q
V
F
V
K
F
S
V
G
L
D
A
V
E
L
L
K
Q
I
D
E
L
D
I
L
R
L
K
900
901
L
E
N
N
I
D
I
I
D
Q
L
N
T
L
S
S
L
T
V
N
I
S
S
C
V
L
Y
D
R
I
Q
A
A
K
T
I
D
E
M
E
R
E
A
K
R
L
Y
K
S
N
E
L
F
G
S
V
I
F
K
L
960
961
P
S
N
R
S
W
H
R
G
Y
D
S
G
N
V
F
L
P
P
V
I
K
Y
T
I
R
M
S
L
K
T
A
Q
T
T
R
S
L
R
T
K
I
W
A
P
G
P
H
N
S
P
S
H
N
Q
I
Y
G
R
A
1020
1021
F
I
Y
L
Q
D
S
I
E
R
A
I
I
E
L
Q
T
G
R
N
S
Q
E
I
A
V
Q
V
Q
A
I
P
Y
P
C
F
M
K
D
N
F
L
T
S
V
S
Y
S
L
P
I
V
L
M
V
A
W
V
V
F
1080
1081
I
A
A
F
V
K
K
L
V
Y
E
K
D
L
R
L
H
E
Y
M
K
M
M
G
V
N
S
C
S
H
F
F
A
W
L
I
E
S
V
G
F
L
L
V
T
I
V
I
L
I
I
I
L
K
F
G
N
I
L
P
1140
1141
K
T
N
G
F
I
L
F
L
Y
F
S
D
Y
S
F
S
V
I
A
M
S
Y
L
I
S
V
F
F
N
N
T
N
I
A
A
L
I
G
S
L
I
Y
I
I
A
F
F
P
F
I
V
L
V
T
V
E
N
E
L
1200
1201
S
Y
V
L
K
V
F
M
S
L
L
S
P
T
A
F
S
Y
A
S
Q
Y
I
A
R
Y
E
E
Q
G
I
G
L
Q
W
E
N
M
Y
T
S
P
V
Q
D
D
T
T
S
F
G
W
L
C
C
L
I
L
A
D
1260
1261
S
F
I
Y
F
L
I
A
W
Y
V
R
N
V
F
P
G
T
Y
G
M
A
A
P
W
Y
F
P
I
L
P
S
Y
W
K
E
R
F
G
C
A
E
V
K
P
E
K
S
N
G
L
M
F
T
N
I
M
M
Q
N
1320
1321
T
N
P
S
A
S
P
E
Y
M
F
S
S
N
I
E
P
E
P
K
D
L
T
V
G
V
A
L
H
G
V
T
K
I
Y
G
S
K
V
A
V
D
N
L
N
L
N
F
Y
E
G
H
I
T
S
L
L
G
P
N
1380
1381
G
A
G
K
T
T
T
I
S
M
L
T
G
L
F
G
A
S
A
G
T
I
F
V
Y
G
K
D
I
K
T
D
L
H
T
V
R
K
N
M
G
V
C
M
Q
H
D
V
L
F
S
Y
L
T
T
K
E
H
L
L
1440
1441
L
Y
G
S
I
K
V
P
H
W
T
K
K
Q
L
H
E
E
V
K
R
T
L
K
D
T
G
L
Y
S
H
R
H
K
R
V
G
T
L
S
G
G
M
K
R
K
L
S
I
S
I
A
L
I
G
G
S
R
V
V
1500
1501
I
L
D
E
P
S
T
G
V
D
P
C
S
R
R
S
I
W
D
V
I
S
K
N
K
T
A
R
T
I
I
L
S
T
H
H
L
D
E
A
E
V
L
S
D
R
I
A
F
L
E
Q
G
G
L
R
C
C
G
S
1560
1561
P
F
Y
L
K
E
A
F
G
D
G
Y
H
L
T
L
T
K
K
K
S
P
N
L
N
A
N
A
V
C
D
T
M
A
V
T
A
M
I
Q
S
H
L
P
E
A
Y
L
K
E
D
I
G
G
E
L
V
Y
V
L
1620
1621
P
P
F
S
T
K
V
S
G
A
Y
L
S
L
L
R
A
L
D
N
G
M
G
D
L
N
I
G
C
Y
G
I
S
D
T
T
V
E
E
V
F
L
N
L
T
K
E
S
Q
K
N
S
A
M
S
L
E
H
L
T
1680
1681
Q
K
K
I
G
N
S
N
A
N
G
I
S
T
P
D
D
L
S
V
S
S
S
N
F
T
D
R
D
D
K
I
L
T
R
G
E
R
L
D
G
F
G
L
L
L
K
K
I
M
A
I
L
I
K
R
F
H
H
T
1740
1741
R
R
N
W
K
G
L
I
A
Q
V
I
L
P
I
V
F
V
T
T
A
M
G
L
G
T
L
R
N
S
S
N
S
Y
P
E
I
Q
I
S
P
S
L
Y
G
T
S
E
Q
T
A
F
Y
A
N
Y
H
P
S
T
1800
1801
E
A
L
V
S
A
M
W
D
F
P
G
I
D
N
M
C
L
N
T
S
D
L
Q
C
L
N
K
D
S
L
E
K
W
N
T
S
G
E
P
I
T
N
F
G
V
C
S
C
S
E
N
V
Q
E
C
P
K
F
N
1860
1861
Y
S
P
P
H
R
R
T
Y
S
S
Q
V
I
Y
N
L
T
G
Q
R
V
E
N
Y
L
I
S
T
A
N
E
F
V
Q
K
R
Y
G
G
W
S
F
G
L
P
L
T
K
D
L
R
F
D
I
T
G
V
P
A
1920
1921
N
R
T
L
A
K
V
W
Y
D
P
E
G
Y
H
S
L
P
A
Y
L
N
S
L
N
N
F
L
L
R
V
N
M
S
K
Y
D
A
A
R
H
G
I
I
M
Y
S
H
P
Y
P
G
V
Q
D
Q
E
Q
A
T
1980
1981
I
S
S
L
I
D
I
L
V
A
L
S
I
L
M
G
Y
S
V
T
T
A
S
F
V
T
Y
V
V
R
E
H
Q
T
K
A
K
Q
L
Q
H
I
S
G
I
G
V
T
C
Y
W
V
T
N
F
I
Y
D
M
V
2040
2041
F
Y
L
V
P
V
A
F
S
I
G
I
I
A
I
F
K
L
P
A
F
Y
S
E
N
N
L
G
A
V
S
L
L
L
L
L
F
G
Y
A
T
F
S
W
M
Y
L
L
A
G
L
F
H
E
T
G
M
A
F
I
2100
2101
T
Y
V
C
V
N
L
F
F
G
I
N
S
I
V
S
L
S
V
V
Y
F
L
S
K
E
K
P
N
D
P
T
L
E
L
I
S
E
T
L
K
R
I
F
L
I
F
P
Q
F
C
F
G
Y
G
L
I
E
L
S
2160
2161
Q
Q
Q
S
V
L
D
F
L
K
A
Y
G
V
E
Y
P
N
E
T
F
E
M
N
K
L
G
A
M
F
V
A
L
V
S
Q
G
T
M
F
F
S
L
R
L
L
I
N
E
S
L
I
K
K
L
R
L
F
F
R
2220
2221
K
F
N
S
S
H
V
R
E
T
I
D
E
D
E
D
V
R
A
E
R
L
R
V
E
S
G
A
A
E
F
D
L
V
Q
L
Y
C
L
T
K
T
Y
Q
L
I
H
K
K
I
I
A
V
N
N
I
S
I
G
I
2280
2281
P
A
G
E
C
F
G
L
L
G
V
N
G
A
G
K
T
T
I
F
K
M
L
T
G
D
I
I
P
S
S
G
N
I
L
I
R
N
K
T
G
S
L
G
H
V
D
S
H
S
S
L
V
G
Y
C
P
Q
E
D
2340
2341
A
L
D
D
L
V
T
V
E
E
H
L
Y
F
Y
A
R
V
H
G
I
P
E
K
D
I
K
E
T
V
H
K
L
L
R
R
L
H
L
M
P
F
K
D
R
A
T
S
M
C
S
Y
G
T
K
R
K
L
S
T
2400
2401
A
L
A
L
I
G
K
P
S
I
L
L
L
D
E
P
S
S
G
M
D
P
K
S
K
R
H
L
W
K
I
I
S
E
E
V
Q
N
K
C
S
V
I
L
T
S
H
S
M
E
E
C
E
A
L
C
T
R
L
A
2460
2461
I
M
V
N
G
K
F
Q
C
I
G
S
L
Q
H
I
K
S
R
F
G
R
G
F
T
V
K
V
H
L
K
N
N
K
V
T
M
E
T
L
T
K
F
M
Q
L
H
F
P
K
T
Y
L
K
D
Q
H
L
S
M
2520
2521
L
E
Y
H
V
P
V
T
A
G
G
V
A
N
I
F
D
L
L
E
T
N
K
T
A
L
N
I
T
N
F
L
V
S
Q
T
T
L
E
E
V
F
I
N
F
A
K
D
Q
K
S
Y
E
T
A
D
T
S
S
Q
2580
2581
G
S
T
I
S
V
D
S
Q
D
D
Q
M
E
S
2595
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1226
Peptide:
VFFNNT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q86UK0
UniProt Name:
ABCAC_HUMAN
Protein Name:
ATP-binding cassette sub-family A member 12
Position:
1167-1172
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
11.4
Area of the profile Above Threshold (AGGRESCAN):
1.83
Best Energy Score (PASTA 2.0):
-3.82
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1227 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1227
Peptide:
VFIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624F
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.9
Tango:
114.52
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
95.7
Area of the profile Above Threshold (AGGRESCAN):
6.39
Best Energy Score (PASTA 2.0):
-7.3
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1228 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1228
Peptide:
VGFGNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
140-145
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.3
Area of the profile Above Threshold (AGGRESCAN):
0.59
Best Energy Score (PASTA 2.0):
-0.22
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1229 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1229
Peptide:
VGIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624G
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.59
Tango:
0.87
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
65.2
Area of the profile Above Threshold (AGGRESCAN):
4.33
Best Energy Score (PASTA 2.0):
-5.08
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1230 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1230
Peptide:
VGQGSD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
81-86
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-66.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.01
Aggregate Orientation (PASTA 2.0):
Antiparallel
