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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Statistics
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1861 to 1890 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1861
GYEVHHQKLVFFAEDVGSN
19
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1862
NLKHQPGGGKVQIVYKEVD
19
Amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
CPAD, AmyLoad
P-1863
RQGVEDAFYTLVREIRQHK
19
Amyloid
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
CPAD, AmyLoad
P-1864
STNVKTAFEMVILDIYNNV
19
Amyloid
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
CPAD, AmyLoad
P-1865
VLSEGEWQLVLHVWAKVEA
19
Amyloid
Myoglobin
P02185
No
Protein Sci. 1997 Mar;6(3):706-16.
9070453
CPAD, AmyLoad
P-1866
AMALNCDPVWLQYGTKRGKA
20
Non-amyloid
Regulatory protein cro (Antirepressor)
P03036
No
Protein Sci. 1999 Aug;8(8):1675-88.
10452612
AmyLoad
P-1867
DHPAVMEGTKTILETDSNLS
20
Non-amyloid
Transcriptional regulatory protein ComA (Competence protein A)
P14204
No
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1868
DILTLLNSTNKDWWKVEVND
20
Amyloid
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Q13813
No
J Mol Biol. 1996 Jan 26;255(3):507-21.
8568894
CPAD, AmyLoad
P-1869
DWSFYLLYYTEFTPTGKDEY
20
Amyloid
Beta-2-microglobulin
P61769
No
J Mol Biol. 2003 Jan 10;325(2):249-57.
12488093
AmyLoad
P-1870
EPDEAEQDSIEFGKKIANIY
20
Non-amyloid
Flavodoxin
P00322
C128S, [del]Y
J Mol Biol. 1995 Apr 7;247(4):648-69.
7723021
AmyLoad
P-1871
EQVTNVGGAVVTGVTAVAQK
20
Amyloid
Alpha-synuclein
P37840
No
FEBS Lett. 2002 Jul 3;522(1-3):9-13.
12095610
CPAD
P-1872
GDAATAEKVFKQYANDNGVD
20
Non-amyloid
Immunoglobulin G-binding protein G (IgG-binding protein G)
P06654
V247G
Eur J Biochem. 1995 Jun 1;230(2):634-49.
7607238
AmyLoad
P-1873
GEKIVFKNNAGFPHNVVFDE
20
Amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
CPAD, AmyLoad
P-1874
GVVGWVKNTSKGTVTGQVQG
20
Amyloid
Acylphosphatase-2
P14621
No
Nat Struct Biol. 2002 Feb;9(2):137-43.
11799398
CPAD, AmyLoad
P-1875
KETAAAKFERQHMDSSTSAA
20
Amyloid
Ribonuclease (RNase A)
P61823
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1876
MAIVGTIIKIIKAIIDIFAK
20
Amyloid
CPAD
P-1877
NFLNCYVSGFHPSDIEVDLL
20
Amyloid
Beta-2-microglobulin
P61769
No
Biochem Biophys Res Commun. 2003 Apr 25;304(1):101-6.
12705891
AmyLoad
P-1878
PGGGSVQIVYKPVDLSKVTS
20
Amyloid
Microtubule-associated protein tau (PHF-tau)
P10636-8
No
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10278-83.
15240881
AmyLoad
P-1879
QISFADYNLLDLLRIHQVLN
20
Amyloid
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
11370666
CPAD, AmyLoad
P-1880
SEDLKKHGVTVLTALGAILK
20
Non-amyloid
Myoglobin
P02185
No
Protein Sci. 1997 Mar;6(3):706-16.
9070453
AmyLoad
P-1881
SEVVFNSKEQGSWGREERGP
20
Non-amyloid
Galectin-7
P47929
No
J Biol Chem. 2014 Oct 17;289(42):29195-207
25172508
CPAD
P-1882
TESKEKITQYIYHVLNGEIL
20
Amyloid
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
CPAD, AmyLoad
P-1883
WNFAGIEAAASAIQGNVTSI
20
Amyloid
6 kDa early secretory antigenic target (ESAT-6)
P9WNK7
No
PLoS Biol. 2008 Aug 5;6(8):e195.
18684013
CPAD
P-1884
DWSFYLLYYTEFTPTGKDEYA
21
Amyloid
Beta-2-microglobulin
P61769
E94G
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1885
GEYTVDVADKGYTLNIKFAGD
21
Amyloid
Protein Sci. 1997 Jan;6(1):162-74.
9007989
CPAD, AmyLoad
P-1886
GYMLGSAMSRPIIHFGSDYED
21
Amyloid
Major prion protein (PrP)
P04156
No
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9678-82.
8105481
AmyLoad
P-1887
KTNMKHMAGAAAAGAVVGGLG
21
Amyloid
Major prion protein (PrP)
P04156
No
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9678-82.
8105481
AmyLoad
P-1888
MGIIAGIIKFIKGLIEKFTGK
21
Amyloid
CPAD
P-1889
MGIIAGIIKVIKSLIEQFTGK
21
Amyloid
CPAD
P-1890
PFTAATLEEKLNKIFEKLGMY
21
Amyloid
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
CPAD, AmyLoad
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Entry: P-1861 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1861
Peptide:
GYEVHHQKLVFFAEDVGSN
Length:
19
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
680-698
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
42.11
NuAPRpred:
1.24
Tango:
431.46
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.4
Area of the profile Above Threshold (AGGRESCAN):
3.82
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1862 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1862
Peptide:
NLKHQPGGGKVQIVYKEVD
Length:
19
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
36.84
NuAPRpred:
-1.49
Tango:
77.93
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.4
Area of the profile Above Threshold (AGGRESCAN):
3.15
Best Energy Score (PASTA 2.0):
-4.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1863 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1863
Peptide:
RQGVEDAFYTLVREIRQHK
Length:
19
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
P21-ras
Protein Name:
Position:
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
7
Hydrophobicity:
36.84
NuAPRpred:
-3.5
Tango:
345.21
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.7
Area of the profile Above Threshold (AGGRESCAN):
3.3
Best Energy Score (PASTA 2.0):
-4.16
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1864 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1864
Peptide:
STNVKTAFEMVILDIYNNV
Length:
19
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
52.63
NuAPRpred:
1.04
Tango:
48.38
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
21.8
Area of the profile Above Threshold (AGGRESCAN):
6.45
Best Energy Score (PASTA 2.0):
-7.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1865 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
V
L
S
E
G
E
W
Q
L
V
L
H
V
W
A
K
V
E
A
D
V
A
G
H
G
Q
D
I
L
I
R
L
F
K
S
H
P
E
T
L
E
K
F
D
R
F
K
H
L
K
T
E
A
E
M
K
A
S
E
60
61
D
L
K
K
H
G
V
T
V
L
T
A
L
G
A
I
L
K
K
K
G
H
H
E
A
E
L
K
P
L
A
Q
S
H
A
T
K
H
K
I
P
I
K
Y
L
E
F
I
S
E
A
I
I
H
V
L
H
S
R
H
120
121
P
G
D
F
G
A
D
A
Q
G
A
M
N
K
A
L
E
L
F
R
K
D
I
A
A
K
Y
K
E
L
G
Y
Q
G
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1865
Peptide:
VLSEGEWQLVLHVWAKVEA
Length:
19
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02185
UniProt Name:
MYG_PHYMC
Protein Name:
Myoglobin
Position:
2-20
Literature
PMID:
9070453
Reference:
Protein Sci. 1997 Mar;6(3):706-16.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
57.89
NuAPRpred:
6.1
Tango:
146.16
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
11.0
Area of the profile Above Threshold (AGGRESCAN):
5.18
Best Energy Score (PASTA 2.0):
-6.5
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1866 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
T
L
S
E
R
L
K
K
R
R
I
A
L
K
M
T
Q
T
E
L
A
T
K
A
G
V
K
Q
Q
S
I
Q
L
I
E
A
G
V
T
K
R
P
R
F
L
F
E
I
A
M
A
L
N
C
D
P
V
W
60
61
L
Q
Y
G
T
K
R
G
K
A
A
71
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1866
Peptide:
AMALNCDPVWLQYGTKRGKA
Length:
20
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P03036
UniProt Name:
RCRO_BP434
Protein Name:
Regulatory protein cro (Antirepressor)
Position:
51-70
Literature
PMID:
10452612
Reference:
Protein Sci. 1999 Aug;8(8):1675-88.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
55.0
NuAPRpred:
-3.18
Tango:
22.29
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-10.5
Area of the profile Above Threshold (AGGRESCAN):
3.11
Best Energy Score (PASTA 2.0):
-2.66
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1867 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
K
I
L
V
I
D
D
H
P
A
V
M
E
G
T
K
T
I
L
E
T
D
S
N
L
S
V
D
C
L
S
P
E
P
S
E
Q
F
I
K
Q
H
D
F
S
S
Y
D
L
I
L
M
D
L
N
L
G
G
60
61
E
V
N
G
M
E
L
S
K
Q
I
L
Q
E
N
P
H
C
K
I
I
V
Y
T
G
Y
E
V
E
D
Y
F
E
E
A
I
R
A
G
L
H
G
A
I
S
K
T
E
S
K
E
K
I
T
Q
Y
I
Y
H
V
120
121
L
N
G
E
I
L
V
D
F
A
Y
F
K
Q
L
M
T
Q
Q
K
T
K
P
A
P
S
S
Q
K
E
Q
D
V
L
T
P
R
E
C
L
I
L
Q
E
V
E
K
G
F
T
N
Q
E
I
A
D
A
L
H
L
180
181
S
K
R
S
I
E
Y
S
L
T
S
I
F
N
K
L
N
V
G
S
R
T
E
A
V
L
I
A
K
S
D
G
V
L
214
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1867
Peptide:
DHPAVMEGTKTILETDSNLS
Length:
20
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14204
UniProt Name:
CMPA_BACSU
Protein Name:
Transcriptional regulatory protein ComA (Competence protein A)
Position:
9-28
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
5
Hydrophobicity:
35.0
NuAPRpred:
-6.94
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-25.1
Area of the profile Above Threshold (AGGRESCAN):
1.54
Best Energy Score (PASTA 2.0):
-2.46
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1868 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
P
S
G
V
K
V
L
E
T
A
E
D
I
Q
E
R
R
Q
Q
V
L
D
R
Y
H
R
F
K
E
L
S
T
L
R
R
Q
K
L
E
D
S
Y
R
F
Q
F
F
Q
R
D
A
E
E
L
E
K
W
I
60
61
Q
E
K
L
Q
I
A
S
D
E
N
Y
K
D
P
T
N
L
Q
G
K
L
Q
K
H
Q
A
F
E
A
E
V
Q
A
N
S
G
A
I
V
K
L
D
E
T
G
N
L
M
I
S
E
G
H
F
A
S
E
T
I
120
121
R
T
R
L
M
E
L
H
R
Q
W
E
L
L
L
E
K
M
R
E
K
G
I
K
L
L
Q
A
Q
K
L
V
Q
Y
L
R
E
C
E
D
V
M
D
W
I
N
D
K
E
A
I
V
T
S
E
E
L
G
Q
D
180
181
L
E
H
V
E
V
L
Q
K
K
F
E
E
F
Q
T
D
M
A
A
H
E
E
R
V
N
E
V
N
Q
F
A
A
K
L
I
Q
E
Q
H
P
E
E
E
L
I
K
T
K
Q
D
E
V
N
A
A
W
Q
R
L
240
241
K
G
L
A
L
Q
R
Q
G
K
L
F
G
A
A
E
V
Q
R
F
N
R
D
V
D
E
T
I
S
W
I
K
E
K
E
Q
L
M
A
S
D
D
F
G
R
D
L
A
S
V
Q
A
L
L
R
K
H
E
G
L
300
301
E
R
D
L
A
A
L
E
D
K
V
K
A
L
C
A
E
A
D
R
L
Q
Q
S
H
P
L
S
A
T
Q
I
Q
V
K
R
E
E
L
I
T
N
W
E
Q
I
R
T
L
A
A
E
R
H
A
R
L
N
D
S
360
361
Y
R
L
Q
R
F
L
A
D
F
R
D
L
T
S
W
V
T
E
M
K
A
L
I
N
A
D
E
L
A
S
D
V
A
G
A
E
A
L
L
D
R
H
Q
E
H
K
G
E
I
D
A
H
E
D
S
F
K
S
A
420
421
D
E
S
G
Q
A
L
L
A
A
G
H
Y
A
S
D
E
V
R
E
K
L
T
V
L
S
E
E
R
A
A
L
L
E
L
W
E
L
R
R
Q
Q
Y
E
Q
C
M
D
L
Q
L
F
Y
R
D
T
E
Q
V
D
480
481
N
W
M
S
K
Q
E
A
F
L
L
N
E
D
L
G
D
S
L
D
S
V
E
A
L
L
K
K
H
E
D
F
E
K
S
L
S
A
Q
E
E
K
I
T
A
L
D
E
F
A
T
K
L
I
Q
N
N
H
Y
A
540
541
M
E
D
V
A
T
R
R
D
A
L
L
S
R
R
N
A
L
H
E
R
A
M
R
R
R
A
Q
L
A
D
S
F
H
L
Q
Q
F
F
R
D
S
D
E
L
K
S
W
V
N
E
K
M
K
T
A
T
D
E
A
600
601
Y
K
D
P
S
N
L
Q
G
K
V
Q
K
H
Q
A
F
E
A
E
L
S
A
N
Q
S
R
I
D
A
L
E
K
A
G
Q
K
L
I
D
V
N
H
Y
A
K
D
E
V
A
A
R
M
N
E
V
I
S
L
W
660
661
K
K
L
L
E
A
T
E
L
K
G
I
K
L
R
E
A
N
Q
Q
Q
Q
F
N
R
N
V
E
D
I
E
L
W
L
Y
E
V
E
G
H
L
A
S
D
D
Y
G
K
D
L
T
N
V
Q
N
L
Q
K
K
H
720
721
A
L
L
E
A
D
V
A
A
H
Q
D
R
I
D
G
I
T
I
Q
A
R
Q
F
Q
D
A
G
H
F
D
A
E
N
I
K
K
K
Q
E
A
L
V
A
R
Y
E
A
L
K
E
P
M
V
A
R
K
Q
K
L
780
781
A
D
S
L
R
L
Q
Q
L
F
R
D
V
E
D
E
E
T
W
I
R
E
K
E
P
I
A
A
S
T
N
R
G
K
D
L
I
G
V
Q
N
L
L
K
K
H
Q
A
L
Q
A
E
I
A
G
H
E
P
R
I
840
841
K
A
V
T
Q
K
G
N
A
M
V
E
E
G
H
F
A
A
E
D
V
K
A
K
L
H
E
L
N
Q
K
W
E
A
L
K
A
K
A
S
Q
R
R
Q
D
L
E
D
S
L
Q
A
Q
Q
Y
F
A
D
A
N
900
901
E
A
E
S
W
M
R
E
K
E
P
I
V
G
S
T
D
Y
G
K
D
E
D
S
A
E
A
L
L
K
K
H
E
A
L
M
S
D
L
S
A
Y
G
S
S
I
Q
A
L
R
E
Q
A
Q
S
C
R
Q
Q
V
960
961
A
P
T
D
D
E
T
G
K
E
L
V
L
A
L
Y
D
Y
Q
E
K
S
P
R
E
V
T
M
K
K
G
D
I
L
T
L
L
N
S
T
N
K
D
W
W
K
V
E
V
N
D
R
Q
G
F
V
P
A
A
Y
1020
1021
V
K
K
L
D
P
A
Q
S
A
S
R
E
N
L
L
E
E
Q
G
S
I
A
L
R
Q
E
Q
I
D
N
Q
T
R
I
T
K
E
A
G
S
V
S
L
R
M
K
Q
V
E
E
L
Y
H
S
L
L
E
L
G
1080
1081
E
K
R
K
G
M
L
E
K
S
C
K
K
F
M
L
F
R
E
A
N
E
L
Q
Q
W
I
N
E
K
E
A
A
L
T
S
E
E
V
G
A
D
L
E
Q
V
E
V
L
Q
K
K
F
D
D
F
Q
K
D
L
1140
1141
K
A
N
E
S
R
L
K
D
I
N
K
V
A
E
D
L
E
S
E
G
L
M
A
E
E
V
Q
A
V
Q
Q
Q
E
V
Y
G
M
M
P
R
D
E
T
D
S
K
T
A
S
P
W
K
S
A
R
L
M
V
H
1200
1201
T
V
A
T
F
N
S
I
K
E
L
N
E
R
W
R
S
L
Q
Q
L
A
E
E
R
S
Q
L
L
G
S
A
H
E
V
Q
R
F
H
R
D
A
D
E
T
K
E
W
I
E
E
K
N
Q
A
L
N
T
D
N
1260
1261
Y
G
H
D
L
A
S
V
Q
A
L
Q
R
K
H
E
G
F
E
R
D
L
A
A
L
G
D
K
V
N
S
L
G
E
T
A
E
R
L
I
Q
S
H
P
E
S
A
E
D
L
Q
E
K
C
T
E
L
N
Q
A
1320
1321
W
S
S
L
G
K
R
A
D
Q
R
K
A
K
L
G
D
S
H
D
L
Q
R
F
L
S
D
F
R
D
L
M
S
W
I
N
G
I
R
G
L
V
S
S
D
E
L
A
K
D
V
T
G
A
E
A
L
L
E
R
1380
1381
H
Q
E
H
R
T
E
I
D
A
R
A
G
T
F
Q
A
F
E
Q
F
G
Q
Q
L
L
A
H
G
H
Y
A
S
P
E
I
K
Q
K
L
D
I
L
D
Q
E
R
A
D
L
E
K
A
W
V
Q
R
R
M
M
1440
1441
L
D
Q
C
L
E
L
Q
L
F
H
R
D
C
E
Q
A
E
N
W
M
A
A
R
E
A
F
L
N
T
E
D
K
G
D
S
L
D
S
V
E
A
L
I
K
K
H
E
D
F
D
K
A
I
N
V
Q
E
E
K
1500
1501
I
A
A
L
Q
A
F
A
D
Q
L
I
A
A
G
H
Y
A
K
G
D
I
S
S
R
R
N
E
V
L
D
R
W
R
R
L
K
A
Q
M
I
E
K
R
S
K
L
G
E
S
Q
T
L
Q
Q
F
S
R
D
V
1560
1561
D
E
I
E
A
W
I
S
E
K
L
Q
T
A
S
D
E
S
Y
K
D
P
T
N
I
Q
S
K
H
Q
K
H
Q
A
F
E
A
E
L
H
A
N
A
D
R
I
R
G
V
I
D
M
G
N
S
L
I
E
R
G
1620
1621
A
C
A
G
S
E
D
A
V
K
A
R
L
A
A
L
A
D
Q
W
Q
F
L
V
Q
K
S
A
E
K
S
Q
K
L
K
E
A
N
K
Q
Q
N
F
N
T
G
I
K
D
F
D
F
W
L
S
E
V
E
A
L
1680
1681
L
A
S
E
D
Y
G
K
D
L
A
S
V
N
N
L
L
K
K
H
Q
L
L
E
A
D
I
S
A
H
E
D
R
L
K
D
L
N
S
Q
A
D
S
L
M
T
S
S
A
F
D
T
S
Q
V
K
D
K
R
D
1740
1741
T
I
N
G
R
F
Q
K
I
K
S
M
A
A
S
R
R
A
K
L
N
E
S
H
R
L
H
Q
F
F
R
D
M
D
D
E
E
S
W
I
K
E
K
K
L
L
V
G
S
E
D
Y
G
R
D
L
T
G
V
Q
1800
1801
N
L
R
K
K
H
K
R
L
E
A
E
L
A
A
H
E
P
A
I
Q
G
V
L
D
T
G
K
K
L
S
D
D
N
T
I
G
K
E
E
I
Q
Q
R
L
A
Q
F
V
E
H
W
K
E
L
K
Q
L
A
A
1860
1861
A
R
G
Q
R
L
E
E
S
L
E
Y
Q
Q
F
V
A
N
V
E
E
E
E
A
W
I
N
E
K
M
T
L
V
A
S
E
D
Y
G
D
T
L
A
A
I
Q
G
L
L
K
K
H
E
A
F
E
T
D
F
T
1920
1921
V
H
K
D
R
V
N
D
V
C
T
N
G
Q
D
L
I
K
K
N
N
H
H
E
E
N
I
S
S
K
M
K
G
L
N
G
K
V
S
D
L
E
K
A
A
A
Q
R
K
A
K
L
D
E
N
S
A
F
L
Q
1980
1981
F
N
W
K
A
D
V
V
E
S
W
I
G
E
K
E
N
S
L
K
T
D
D
Y
G
R
D
L
S
S
V
Q
T
L
L
T
K
Q
E
T
F
D
A
G
L
Q
A
F
Q
Q
E
G
I
A
N
I
T
A
L
K
2040
2041
D
Q
L
L
A
A
K
H
V
Q
S
K
A
I
E
A
R
H
A
S
L
M
K
R
W
S
Q
L
L
A
N
S
A
A
R
K
K
K
L
L
E
A
Q
S
H
F
R
K
V
E
D
L
F
L
T
F
A
K
K
A
2100
2101
S
A
F
N
S
W
F
E
N
A
E
E
D
L
T
D
P
V
R
C
N
S
L
E
E
I
K
A
L
R
E
A
H
D
A
F
R
S
S
L
S
S
A
Q
A
D
F
N
Q
L
A
E
L
D
R
Q
I
K
S
F
2160
2161
R
V
A
S
N
P
Y
T
W
F
T
M
E
A
L
E
E
T
W
R
N
L
Q
K
I
I
K
E
R
E
L
E
L
Q
K
E
Q
R
R
Q
E
E
N
D
K
L
R
Q
E
F
A
Q
H
A
N
A
F
H
Q
W
2220
2221
I
Q
E
T
R
T
Y
L
L
D
G
S
C
M
V
E
E
S
G
T
L
E
S
Q
L
E
A
T
K
R
K
H
Q
E
I
R
A
M
R
S
Q
L
K
K
I
E
D
L
G
A
A
M
E
E
A
L
I
L
D
N
2280
2281
K
Y
T
E
H
S
T
V
G
L
A
Q
Q
W
D
Q
L
D
Q
L
G
M
R
M
Q
H
N
L
E
Q
Q
I
Q
A
R
N
T
T
G
V
T
E
E
A
L
K
E
F
S
M
M
F
K
H
F
D
K
D
K
S
2340
2341
G
R
L
N
H
Q
E
F
K
S
C
L
R
S
L
G
Y
D
L
P
M
V
E
E
G
E
P
D
P
E
F
E
A
I
L
D
T
V
D
P
N
R
D
G
H
V
S
L
Q
E
Y
M
A
F
M
I
S
R
E
T
2400
2401
E
N
V
K
S
S
E
E
I
E
S
A
F
R
A
L
S
S
E
G
K
P
Y
V
T
K
E
E
L
Y
Q
N
L
T
R
E
Q
A
D
Y
C
V
S
H
M
K
P
Y
V
D
G
K
G
R
E
L
P
T
A
F
2460
2461
D
Y
V
E
F
T
R
S
L
F
V
N
2472
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1868
Peptide:
DILTLLNSTNKDWWKVEVND
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13813
UniProt Name:
SPTN1_HUMAN
Protein Name:
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Position:
992-1011
Literature
PMID:
8568894
Reference:
J Mol Biol. 1996 Jan 26;255(3):507-21.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
6
Hydrophobicity:
40.0
NuAPRpred:
0.39
Tango:
401.56
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-10.5
Area of the profile Above Threshold (AGGRESCAN):
3.6
Best Energy Score (PASTA 2.0):
-4.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1869 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1869
Peptide:
DWSFYLLYYTEFTPTGKDEY
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
79-98
Literature
PMID:
12488093
Reference:
J Mol Biol. 2003 Jan 10;325(2):249-57.
source:
AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
5
Hydrophobicity:
50.0
NuAPRpred:
0.65
Tango:
764.39
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
11.5
Area of the profile Above Threshold (AGGRESCAN):
7.39
Best Energy Score (PASTA 2.0):
-4.32
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1870 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
I
V
Y
W
S
G
T
G
N
T
E
K
M
A
E
L
I
A
K
G
I
I
E
S
G
K
D
V
N
T
I
N
V
S
D
V
N
I
D
E
L
L
N
E
D
I
L
I
L
G
C
S
A
M
G
D
E
V
60
61
L
E
E
S
E
F
E
P
F
I
E
E
I
S
T
K
I
S
G
K
K
V
A
L
F
G
S
Y
G
W
G
D
G
K
W
M
R
D
F
E
E
R
M
N
G
Y
G
C
V
V
V
E
T
P
L
I
V
Q
N
E
120
121
P
D
E
A
E
Q
D
C
I
E
F
G
K
K
I
A
N
I
138
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1870
Peptide:
EPDEAEQDSIEFGKKIANIY
Length:
20
Classification:
Non-amyloid
Mutation(s):
C128S, [del]Y
Structure(s):
No structures
Protein Information
UniProt ID:
P00322
UniProt Name:
FLAV_CLOBE
Protein Name:
Flavodoxin
Position:
120-138
Literature
PMID:
7723021
Reference:
J Mol Biol. 1995 Apr 7;247(4):648-69.
source:
AmyLoad
Derived Information
Net Charge:
-4
Absolute Charge:
8
Hydrophobicity:
40.0
NuAPRpred:
-4.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-40.7
Area of the profile Above Threshold (AGGRESCAN):
2.0
Best Energy Score (PASTA 2.0):
-3.86
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1871 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1871
Peptide:
EQVTNVGGAVVTGVTAVAQK
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
61-80
Literature
PMID:
12095610
Reference:
FEBS Lett. 2002 Jul 3;522(1-3):9-13.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
45.0
NuAPRpred:
1.57
Tango:
681.66
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.5
Area of the profile Above Threshold (AGGRESCAN):
4.93
Best Energy Score (PASTA 2.0):
-7.24
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1872 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
E
K
E
K
K
V
K
Y
F
L
R
K
S
A
F
G
L
A
S
V
S
A
A
F
L
V
G
S
T
V
F
A
V
D
S
P
I
E
D
T
P
I
I
R
N
G
G
E
L
T
N
L
L
G
N
S
E
T
T
60
61
L
A
L
R
N
E
E
S
A
T
A
D
L
T
A
A
A
V
A
D
T
V
A
A
A
A
A
E
N
A
G
A
A
A
W
E
A
A
A
A
A
D
A
L
A
K
A
K
A
D
A
L
K
E
F
N
K
Y
G
V
120
121
S
D
Y
Y
K
N
L
I
N
N
A
K
T
V
E
G
I
K
D
L
Q
A
Q
V
V
E
S
A
K
K
A
R
I
S
E
A
T
D
G
L
S
D
F
L
K
S
Q
T
P
A
E
D
T
V
K
S
I
E
L
A
180
181
E
A
K
V
L
A
N
R
E
L
D
K
Y
G
V
S
D
Y
H
K
N
L
I
N
N
A
K
T
V
E
G
V
K
E
L
I
D
E
I
L
A
A
L
P
K
T
D
T
Y
K
L
I
L
N
G
K
T
L
K
G
240
241
E
T
T
T
E
A
V
D
A
A
T
A
E
K
V
F
K
Q
Y
A
N
D
N
G
V
D
G
E
W
T
Y
D
D
A
T
K
T
F
T
V
T
E
K
P
E
V
I
D
A
S
E
L
T
P
A
V
T
T
Y
K
300
301
L
V
I
N
G
K
T
L
K
G
E
T
T
T
K
A
V
D
A
E
T
A
E
K
A
F
K
Q
Y
A
N
D
N
G
V
D
G
V
W
T
Y
D
D
A
T
K
T
F
T
V
T
E
M
V
T
E
V
P
G
D
360
361
A
P
T
E
P
E
K
P
E
A
S
I
P
L
V
P
L
T
P
A
T
P
I
A
K
D
D
A
K
K
D
D
T
K
K
E
D
A
K
K
P
E
A
K
K
D
D
A
K
K
A
E
T
L
P
T
T
G
E
G
420
421
S
N
P
F
F
T
A
A
A
L
A
V
M
A
G
A
G
A
L
A
V
A
S
K
R
K
E
D
448
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1872
Peptide:
GDAATAEKVFKQYANDNGVD
Length:
20
Classification:
Non-amyloid
Mutation(s):
V247G
Structure(s):
No structures
Protein Information
UniProt ID:
P06654
UniProt Name:
SPG1_STRSG
Protein Name:
Immunoglobulin G-binding protein G (IgG-binding protein G)
Position:
247-266
Literature
PMID:
7607238
Reference:
Eur J Biochem. 1995 Jun 1;230(2):634-49.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
6
Hydrophobicity:
40.0
NuAPRpred:
-5.41
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-41.2
Area of the profile Above Threshold (AGGRESCAN):
0.97
Best Energy Score (PASTA 2.0):
-1.67
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1873 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1873
Peptide:
GEKIVFKNNAGFPHNVVFDE
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
24-43
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
45.0
NuAPRpred:
-3.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.0
Area of the profile Above Threshold (AGGRESCAN):
3.56
Best Energy Score (PASTA 2.0):
-4.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1874 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
T
A
Q
S
L
K
S
V
D
Y
E
V
F
G
R
V
Q
G
V
C
F
R
M
Y
T
E
D
E
A
R
K
I
G
V
V
G
W
V
K
N
T
S
K
G
T
V
T
G
Q
V
Q
G
P
E
D
K
V
N
60
61
S
M
K
S
W
L
S
K
V
G
S
P
S
S
R
I
D
R
T
N
F
S
N
E
K
T
I
S
K
L
E
Y
S
N
F
S
I
R
Y
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1874
Peptide:
GVVGWVKNTSKGTVTGQVQG
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14621
UniProt Name:
ACYP2_HUMAN
Protein Name:
Acylphosphatase-2
Position:
35-54
Literature
PMID:
11799398
Reference:
Nat Struct Biol. 2002 Feb;9(2):137-43.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
30.0
NuAPRpred:
-2.21
Tango:
102.83
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.7
Area of the profile Above Threshold (AGGRESCAN):
3.0
Best Energy Score (PASTA 2.0):
-5.58
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1875 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
K
S
L
V
L
L
S
L
L
V
L
V
L
L
L
V
R
V
Q
P
S
L
G
K
E
T
A
A
A
K
F
E
R
Q
H
M
D
S
S
T
S
A
A
S
S
S
N
Y
C
N
Q
M
M
K
S
R
N
60
61
L
T
K
D
R
C
K
P
V
N
T
F
V
H
E
S
L
A
D
V
Q
A
V
C
S
Q
K
N
V
A
C
K
N
G
Q
T
N
C
Y
Q
S
Y
S
T
M
S
I
T
D
C
R
E
T
G
S
S
K
Y
P
N
120
121
C
A
Y
K
T
T
Q
A
N
K
H
I
I
V
A
C
E
G
N
P
Y
V
P
V
H
F
D
A
S
V
150
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1875
Peptide:
KETAAAKFERQHMDSSTSAA
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61823
UniProt Name:
RNAS1_BOVIN
Protein Name:
Ribonuclease (RNase A)
Position:
27-46
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
6
Hydrophobicity:
35.0
NuAPRpred:
-7.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-45.9
Area of the profile Above Threshold (AGGRESCAN):
0.16
Best Energy Score (PASTA 2.0):
-0.55
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1876 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1876
Peptide:
MAIVGTIIKIIKAIIDIFAK
Length:
20
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
CPAD
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
70.0
NuAPRpred:
8.43
Tango:
806.31
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
65.1
Area of the profile Above Threshold (AGGRESCAN):
13.7
Best Energy Score (PASTA 2.0):
-12.75
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1877 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1877
Peptide:
NFLNCYVSGFHPSDIEVDLL
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
41-60
Literature
PMID:
12705891
Reference:
Biochem Biophys Res Commun. 2003 Apr 25;304(1):101-6.
source:
AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
3
Hydrophobicity:
55.0
NuAPRpred:
1.4
Tango:
22.08
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.8
Area of the profile Above Threshold (AGGRESCAN):
4.85
Best Energy Score (PASTA 2.0):
-4.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1878 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
180
181
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
240
241
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
300
301
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
360
361
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
420
421
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
441
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1878
Peptide:
PGGGSVQIVYKPVDLSKVTS
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10636-8
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
301-320
Literature
PMID:
15240881
Reference:
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10278-83.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
45.0
NuAPRpred:
-2.54
Tango:
38.15
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.5
Area of the profile Above Threshold (AGGRESCAN):
4.3
Best Energy Score (PASTA 2.0):
-4.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1879 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1879
Peptide:
QISFADYNLLDLLRIHQVLN
Length:
20
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
GSTP1_HUMAN
Protein Name:
Position:
Literature
PMID:
11370666
Reference:
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
55.0
NuAPRpred:
-1.21
Tango:
1.5
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.5
Area of the profile Above Threshold (AGGRESCAN):
4.05
Best Energy Score (PASTA 2.0):
-4.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1880 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
L
S
E
G
E
W
Q
L
V
L
H
V
W
A
K
V
E
A
D
V
A
G
H
G
Q
D
I
L
I
R
L
F
K
S
H
P
E
T
L
E
K
F
D
R
F
K
H
L
K
T
E
A
E
M
K
A
S
E
60
61
D
L
K
K
H
G
V
T
V
L
T
A
L
G
A
I
L
K
K
K
G
H
H
E
A
E
L
K
P
L
A
Q
S
H
A
T
K
H
K
I
P
I
K
Y
L
E
F
I
S
E
A
I
I
H
V
L
H
S
R
H
120
121
P
G
D
F
G
A
D
A
Q
G
A
M
N
K
A
L
E
L
F
R
K
D
I
A
A
K
Y
K
E
L
G
Y
Q
G
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1880
Peptide:
SEDLKKHGVTVLTALGAILK
Length:
20
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02185
UniProt Name:
MYG_PHYMC
Protein Name:
Myoglobin
Position:
59-78
Literature
PMID:
9070453
Reference:
Protein Sci. 1997 Mar;6(3):706-16.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
45.0
NuAPRpred:
2.49
Tango:
1017.93
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.9
Area of the profile Above Threshold (AGGRESCAN):
6.16
Best Energy Score (PASTA 2.0):
-6.08
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1881 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
N
V
P
H
K
S
S
L
P
E
G
I
R
P
G
T
V
L
R
I
R
G
L
V
P
P
N
A
S
R
F
H
V
N
L
L
C
G
E
E
Q
G
S
D
A
A
L
H
F
N
P
R
L
D
T
S
E
V
60
61
V
F
N
S
K
E
Q
G
S
W
G
R
E
E
R
G
P
G
V
P
F
Q
R
G
Q
P
F
E
V
L
I
I
A
S
D
D
G
F
K
A
V
V
G
D
A
Q
Y
H
H
F
R
H
R
L
P
L
A
R
V
R
120
121
L
V
E
V
G
G
D
V
Q
L
D
S
V
R
I
F
136
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1881
Peptide:
SEVVFNSKEQGSWGREERGP
Length:
20
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P47929
UniProt Name:
LEG7_HUMAN
Protein Name:
Galectin-7
Position:
58-77
Literature
PMID:
25172508
Reference:
J Biol Chem. 2014 Oct 17;289(42):29195-207
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
7
Hydrophobicity:
25.0
NuAPRpred:
-4.62
Tango:
23.21
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-44.2
Area of the profile Above Threshold (AGGRESCAN):
2.01
Best Energy Score (PASTA 2.0):
-4.88
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1882 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1882
Peptide:
TESKEKITQYIYHVLNGEIL
Length:
20
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
40.0
NuAPRpred:
4.03
Tango:
348.95
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.1
Area of the profile Above Threshold (AGGRESCAN):
4.33
Best Energy Score (PASTA 2.0):
-6.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1883 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
T
E
Q
Q
W
N
F
A
G
I
E
A
A
A
S
A
I
Q
G
N
V
T
S
I
H
S
L
L
D
E
G
K
Q
S
L
T
K
L
A
A
A
W
G
G
S
G
S
E
A
Y
Q
G
V
Q
Q
K
W
D
A
60
61
T
A
T
E
L
N
N
A
L
Q
N
L
A
R
T
I
S
E
A
G
Q
A
M
A
S
T
E
G
N
V
T
G
M
F
A
95
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1883
Peptide:
WNFAGIEAAASAIQGNVTSI
Length:
20
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P9WNK7
UniProt Name:
ESXA_MYCTU
Protein Name:
6 kDa early secretory antigenic target (ESAT-6)
Position:
6-25
Literature
PMID:
18684013
Reference:
PLoS Biol. 2008 Aug 5;6(8):e195.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
55.0
NuAPRpred:
-1.37
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.1
Area of the profile Above Threshold (AGGRESCAN):
2.58
Best Energy Score (PASTA 2.0):
-3.39
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1884 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1884
Peptide:
DWSFYLLYYTEFTPTGKDEYA
Length:
21
Classification:
Amyloid
Mutation(s):
E94G
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
79-99
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
5
Hydrophobicity:
52.38
NuAPRpred:
0.08
Tango:
764.34
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.8
Area of the profile Above Threshold (AGGRESCAN):
7.39
Best Energy Score (PASTA 2.0):
-4.32
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1885 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1885
Peptide:
GEYTVDVADKGYTLNIKFAGD
Length:
21
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
PL B1 protein
Protein Name:
Position:
Literature
PMID:
9007989
Reference:
Protein Sci. 1997 Jan;6(1):162-74.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
6
Hydrophobicity:
42.86
NuAPRpred:
-3.76
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.0
Area of the profile Above Threshold (AGGRESCAN):
3.29
Best Energy Score (PASTA 2.0):
-3.22
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1886 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1886
Peptide:
GYMLGSAMSRPIIHFGSDYED
Length:
21
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
127-147
Literature
PMID:
8105481
Reference:
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9678-82.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
47.62
NuAPRpred:
-5.96
Tango:
0.98
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.5
Area of the profile Above Threshold (AGGRESCAN):
4.81
Best Energy Score (PASTA 2.0):
-4.75
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1887 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1887
Peptide:
KTNMKHMAGAAAAGAVVGGLG
Length:
21
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
106-126
Literature
PMID:
8105481
Reference:
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9678-82.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
52.38
NuAPRpred:
-1.34
Tango:
15.82
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-7.3
Area of the profile Above Threshold (AGGRESCAN):
2.71
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1888 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1888
Peptide:
MGIIAGIIKFIKGLIEKFTGK
Length:
21
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
CPAD
Derived Information
Net Charge:
3
Absolute Charge:
5
Hydrophobicity:
52.38
NuAPRpred:
5.28
Tango:
140.32
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
43.4
Area of the profile Above Threshold (AGGRESCAN):
10.5
Best Energy Score (PASTA 2.0):
-7.63
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1889 Classification: Amyloid
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Peptide details
Entry:
P-1889
Peptide:
MGIIAGIIKVIKSLIEQFTGK
Length:
21
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
CPAD
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
52.38
NuAPRpred:
7.25
Tango:
140.49
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
42.4
Area of the profile Above Threshold (AGGRESCAN):
10.4
Best Energy Score (PASTA 2.0):
-9.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1890 Classification: Amyloid
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JSON
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Peptide details
Entry:
P-1890
Peptide:
PFTAATLEEKLNKIFEKLGMY
Length:
21
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
CHEY_ECOLI
Protein Name:
Position:
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
6
Hydrophobicity:
52.38
NuAPRpred:
-2.27
Tango:
7.7
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.3
Area of the profile Above Threshold (AGGRESCAN):
3.25
Best Energy Score (PASTA 2.0):
-2.26
Aggregate Orientation (PASTA 2.0):
Parallel
