CPAD 2.0

Entry	Peptide	Length	Class	Protein Name	UniProt ID	Mutant	Reference	PMID	Source Database
P-1951	GLSDGEQQVLVWIVNVWGKEADAGHGQEL	29	Amyloid				Biophys J. 2007 Dec 15;93(12):4382-91.	17766358	CPAD
P-1952	GLSDGEQQVLWINVWGKVEADAGHGQEVL	29	Amyloid				Biophys J. 2007 Dec 15;93(12):4382-91.	17766358	CPAD
P-1953	GLSDGEWQQVENVWGKVEADIAGHGQLVL	29	Amyloid				Biophys J. 2007 Dec 15;93(12):4382-91.	17766358	CPAD
P-1954	GLSDGEWQQVLENVWGKVEADIAGHGQVL	29	Amyloid				Biophys J. 2007 Dec 15;93(12):4382-91.	17766358	CPAD
P-1955	GLSDGEWQQVLNVWGKVEADIAGHGQEVL	29	Amyloid				Biophys J. 2007 Dec 15;93(12):4382-91.	17766358	CPAD
P-1956	HSQGTFTSDYSKYLDSRRAQDFVQWLMNT	29	Amyloid	Glucagon	P01275	No	Biochemistry. 2006 Dec 5;45(48):14503-12.	17128989	CPAD
P-1957	GQPFEVLIIASDDGFKAVVGDAQYHHFRHR	30	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1958	VKSEKLDFKDRVQSKIGSLDNITHVPGGGN	30	Non-amyloid	Microtubule-associated protein tau (PHF-tau)	P10636		Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.	10805776	AmyLoad
P-1959	EGEWQLVLHVWAKVEADVAGHGQDILIRLFK	31	Amyloid	Myoglobin	P02185	No	Protein Sci. 1997 Mar;6(3):706-16.	9070453	CPAD, AmyLoad
P-1960	FHVNLLCGEEQGSDAALHFNPRLDTSEVVFN	31	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1961	VNLLCGEEQGSDAALHFNPRLDTSEVVFNSK	31	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1962	YEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV	31	Amyloid	Amyloid-beta precursor protein (APP)	P05067	No	Biophys J. 2006 Jun 15;90(12):4618-29. Epub 2006 Mar 24.	16565054	AmyLoad
P-1963	FHVNLLCGEEQGSDAALHFNPRLDTSEVVFNS	32	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1964	HVNLLCGEEQGSDAALHFNPRLDTSEVVFNSK	32	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1965	FHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSK	33	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1966	YHSRALQVVRARKQIVAGVNYFLDVELGRTTCT	33	Amyloid	Cystatin-C	P01034	No	Nat Struct Biol. 2001 Apr;8(4):316-20.	11276250	CPAD
P-1967	YHSRALQVVRARKQIVAGVNYFLDVEQGRTTCT	33	Amyloid	Cystatin-C	P01034	L94Q	Nat Struct Biol. 2001 Apr;8(4):316-20.	11276250	CPAD
P-1968	EASNCFAIRHFENKFAVETLICFNLFLNSQEKHY	34	Amyloid				Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.	16537487	CPAD, AmyLoad
P-1969	EASNCFAIRHFENKFAVETLICSRTVKKNIIEEN	34	Amyloid				Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.	16537487	CPAD, AmyLoad
P-1970	LPICPGGAARCQTVLRDLFDRAVVLSHYIHNLSS	34	Amyloid	Prolactin (PRL)	P01236	V41T, T42V	Acta Neuropathol. 1997 Jan;93(1):43-9.	9006656	AmyLoad
P-1971	FGIPCCPVHLKRLLIVVVVVVLVVVVIVGALLMGL	35	Amyloid	Pulmonary surfactant-associated protein C (SP-C)	P11686	L46V	Cell Mol Life Sci. 2004 Feb;61(3):326-35.	14770296	AmyLoad
P-1972	FHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQ	35	Non-amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1973	RFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKE	35	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1974	SRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSK	35	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1975	IRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNL	36	Amyloid						CPAD
P-1976	KPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDF	36	Non-amyloid	Microtubule-associated protein tau (PHF-tau)	P10636		Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.	10805776	AmyLoad
P-1977	QTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIVY	36	Non-amyloid	Microtubule-associated protein tau (PHF-tau)	P10636		Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.	10805776	AmyLoad
P-1978	SRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQ	37	Amyloid	Galectin-7	P47929	No	J Biol Chem. 2014 Oct 17;289(42):29195-207	25172508	CPAD
P-1979	GIHKQKEKSRLQGGVLVNEILNHMKRATQIPSYKKLIMY	39	Amyloid						CPAD
P-1980	DAAFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV	40	Amyloid	Amyloid-beta precursor protein (APP)	P05067	E674A	J Mol Biol. 2008 Mar 21;377(2):565-74.	18258258	CPAD

Peptide details

Entry:	P-1951
Peptide:	GLSDGEQQVLVWIVNVWGKEADAGHGQEL
Length:	29
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:	MYG_HUMAN
Protein Name:
Position:

Literature

PMID:	17766358
Reference:	Biophys J. 2007 Dec 15;93(12):4382-91.
source:	CPAD

Derived Information

Net Charge:	-4
Absolute Charge:	6
Hydrophobicity:	41.38
NuAPRpred:	2.16
Tango:	787.45

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-18.6
Area of the profile Above Threshold (AGGRESCAN):	7.75
Best Energy Score (PASTA 2.0):	-12.53
Aggregate Orientation (PASTA 2.0):	Parallel

Peptide details

Entry:	P-1952
Peptide:	GLSDGEQQVLWINVWGKVEADAGHGQEVL
Length:	29
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:	MYG_HUMAN
Protein Name:
Position:

Literature

PMID:	17766358
Reference:	Biophys J. 2007 Dec 15;93(12):4382-91.
source:	CPAD

Derived Information

Net Charge:	-4
Absolute Charge:	6
Hydrophobicity:	41.38
NuAPRpred:	1.05
Tango:	543.67

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-21.1
Area of the profile Above Threshold (AGGRESCAN):	5.09
Best Energy Score (PASTA 2.0):	-8.52
Aggregate Orientation (PASTA 2.0):	Parallel

Peptide details

Entry:	P-1953
Peptide:	GLSDGEWQQVENVWGKVEADIAGHGQLVL
Length:	29
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:	MYG_HUMAN
Protein Name:
Position:

Literature

PMID:	17766358
Reference:	Biophys J. 2007 Dec 15;93(12):4382-91.
source:	CPAD

Derived Information

Net Charge:	-4
Absolute Charge:	6
Hydrophobicity:	41.38
NuAPRpred:	-0.6
Tango:	0.0

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-21.1
Area of the profile Above Threshold (AGGRESCAN):	2.39
Best Energy Score (PASTA 2.0):	-2.27
Aggregate Orientation (PASTA 2.0):	Parallel

Peptide details

Entry:	P-1954
Peptide:	GLSDGEWQQVLENVWGKVEADIAGHGQVL
Length:	29
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:	MYG_HUMAN
Protein Name:
Position:

Literature

PMID:	17766358
Reference:	Biophys J. 2007 Dec 15;93(12):4382-91.
source:	CPAD

Derived Information

Net Charge:	-4
Absolute Charge:	6
Hydrophobicity:	41.38
NuAPRpred:	0.41
Tango:	0.0

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-20.6
Area of the profile Above Threshold (AGGRESCAN):	1.76
Best Energy Score (PASTA 2.0):	-3.02
Aggregate Orientation (PASTA 2.0):	Parallel

Peptide details

Entry:	P-1955
Peptide:	GLSDGEWQQVLNVWGKVEADIAGHGQEVL
Length:	29
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:	MYG_HUMAN
Protein Name:
Position:

Literature

PMID:	17766358
Reference:	Biophys J. 2007 Dec 15;93(12):4382-91.
source:	CPAD

Derived Information

Net Charge:	-4
Absolute Charge:	6
Hydrophobicity:	41.38
NuAPRpred:	0.37
Tango:	22.25

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-21.1
Area of the profile Above Threshold (AGGRESCAN):	2.71
Best Energy Score (PASTA 2.0):	-5.64
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

K

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60

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120

121

A

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K

180

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1956
Peptide:	HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Length:	29
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P01275
UniProt Name:	GLUC_HUMAN
Protein Name:	Glucagon
Position:	53-81

Literature

PMID:	17128989
Reference:	Biochemistry. 2006 Dec 5;45(48):14503-12.
source:	CPAD

Derived Information

Net Charge:	0
Absolute Charge:	6
Hydrophobicity:	34.48
NuAPRpred:	-8.19
Tango:	34.81

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-17.8
Area of the profile Above Threshold (AGGRESCAN):	3.41
Best Energy Score (PASTA 2.0):	-3.35
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

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G

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60

61

V

F

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S

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W

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R

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V

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F

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R

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Q

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F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1957
Peptide:	GQPFEVLIIASDDGFKAVVGDAQYHHFRHR
Length:	30
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	84-113

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-1
Absolute Charge:	7
Hydrophobicity:	46.67
NuAPRpred:	-1.8
Tango:	122.37

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-4.1
Area of the profile Above Threshold (AGGRESCAN):	7.34
Best Energy Score (PASTA 2.0):	-6.71
Aggregate Orientation (PASTA 2.0):	Parallel

Peptide details

Entry:	P-1958
Peptide:	VKSEKLDFKDRVQSKIGSLDNITHVPGGGN
Length:	30
Classification:	Non-amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:	P10636
UniProt Name:	TAU_HUMAN
Protein Name:	Microtubule-associated protein tau (PHF-tau)
Position:

Literature

PMID:	10805776
Reference:	Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:	AmyLoad

Derived Information

Net Charge:	1
Absolute Charge:	9
Hydrophobicity:	30.0
NuAPRpred:	-8.92
Tango:	0.0

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-28.7
Area of the profile Above Threshold (AGGRESCAN):	1.25
Best Energy Score (PASTA 2.0):	-3.97
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

V

L

S

E

G

E

W

Q

L

V

L

H

V

W

A

K

V

E

A

D

V

A

G

H

G

Q

D

I

L

I

R

L

F

K

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H

P

E

T

L

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R

F

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H

L

K

T

E

A

E

M

K

A

S

E

60

61

D

L

K

H

G

V

T

V

L

T

A

L

G

A

I

L

K

G

H

E

A

E

L

K

P

L

A

Q

S

H

A

T

K

H

K

I

P

I

K

Y

L

E

F

I

S

E

A

I

H

V

L

H

S

R

H

120

121

P

G

D

F

G

A

D

A

Q

G

A

M

N

K

A

L

E

L

F

R

K

D

I

A

K

Y

K

E

L

G

Y

Q

G

154

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1959
Peptide:	EGEWQLVLHVWAKVEADVAGHGQDILIRLFK
Length:	31
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P02185
UniProt Name:	MYG_PHYMC
Protein Name:	Myoglobin
Position:	5-35

Literature

PMID:	9070453
Reference:	Protein Sci. 1997 Mar;6(3):706-16.
source:	CPAD, AmyLoad

Derived Information

Net Charge:	-2
Absolute Charge:	8
Hydrophobicity:	51.61
NuAPRpred:	4.09
Tango:	201.17

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	5.4
Area of the profile Above Threshold (AGGRESCAN):	8.51
Best Energy Score (PASTA 2.0):	-6.5
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1960
Peptide:	FHVNLLCGEEQGSDAALHFNPRLDTSEVVFN
Length:	31
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	33-63

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-4
Absolute Charge:	6
Hydrophobicity:	45.16
NuAPRpred:	-3.15
Tango:	4.14

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-12.1
Area of the profile Above Threshold (AGGRESCAN):	5.49
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1961
Peptide:	VNLLCGEEQGSDAALHFNPRLDTSEVVFNSK
Length:	31
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	35-65

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-3
Absolute Charge:	7
Hydrophobicity:	41.94
NuAPRpred:	-4.43
Tango:	7.96

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-15.3
Area of the profile Above Threshold (AGGRESCAN):	5.15
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Sequence

1

M

L

P

G

L

A

L

A

W

T

A

R

A

L

E

V

P

T

D

G

N

A

G

L

A

E

P

Q

I

A

M

F

C

G

R

L

N

M

H

M

N

V

Q

N

G

K

W

D

S

D

P

S

G

T

K

60

61

T

C

I

D

T

K

E

G

I

L

Q

Y

C

Q

E

V

Y

P

E

L

Q

I

T

N

V

E

A

N

Q

P

V

T

I

Q

N

W

C

K

R

G

R

K

Q

C

K

T

H

P

H

F

V

I

P

Y

R

C

L

V

G

120

121

E

F

V

S

D

A

L

V

P

D

K

C

K

F

L

H

Q

E

R

M

D

V

C

E

T

H

L

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W

H

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V

A

K

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C

S

E

K

S

T

N

L

H

D

Y

G

M

L

P

C

G

I

D

K

F

R

180

181

G

V

E

F

V

C

P

L

A

E

S

D

N

V

D

S

A

D

A

E

D

S

D

V

W

G

A

D

T

D

Y

A

D

G

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E

D

K

V

E

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A

E

V

A

E

V

E

240

241

E

A

D

E

D

E

D

G

D

E

V

E

A

E

P

Y

E

A

T

E

R

T

S

I

A

T

E

S

V

E

V

R

E

V

C

S

E

Q

A

E

T

G

P

C

300

301

R

A

M

I

S

R

W

Y

F

D

V

T

E

G

K

C

A

P

F

Y

G

C

G

N

R

N

F

D

T

E

Y

C

M

A

V

C

G

S

A

M

S

Q

S

L

K

T

Q

E

P

L

A

R

D

360

361

P

V

K

L

P

T

A

S

T

P

D

A

V

D

K

Y

L

E

T

P

G

D

E

N

E

H

A

H

F

Q

K

A

K

E

R

L

E

A

K

H

R

E

R

M

S

Q

V

M

R

E

W

E

A

E

R

Q

A

420

421

K

N

L

P

K

A

D

K

A

V

I

Q

H

F

Q

E

K

V

E

S

L

E

Q

E

A

N

E

R

Q

L

V

E

T

H

M

A

R

V

E

A

M

L

N

D

R

L

A

L

E

N

Y

I

T

A

L

480

481

Q

A

V

P

R

P

R

H

V

F

N

M

L

K

Y

V

R

A

E

Q

K

D

R

Q

H

T

L

K

H

F

E

H

V

R

M

V

D

P

K

A

Q

I

R

S

Q

V

M

T

H

L

R

V

I

Y

E

R

540

541

M

N

Q

S

L

S

L

Y

N

V

P

A

V

A

E

I

Q

D

E

V

D

E

L

Q

K

E

Q

N

Y

S

D

V

L

A

N

M

I

S

E

P

R

I

S

Y

G

N

D

A

L

M

P

S

L

T

E

T

600

601

K

T

V

E

L

P

V

N

G

E

F

S

L

D

L

Q

P

W

H

S

F

G

A

D

S

V

P

A

N

T

E

N

E

V

E

P

V

D

A

R

P

A

D

R

G

L

T

R

P

G

S

G

L

T

N

660

661

I

K

T

E

I

S

E

V

K

M

D

A

E

F

R

H

D

S

G

Y

E

V

H

Q

K

L

V

F

A

E

D

V

G

S

N

K

G

A

I

G

L

M

V

G

V

I

A

T

V

I

V

I

T

L

720

721

V

M

L

K

Q

Y

T

S

I

H

G

V

E

V

D

A

V

T

P

E

R

H

L

S

K

M

Q

N

G

Y

E

N

P

T

Y

K

F

E

Q

M

Q

N

770

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1962
Peptide:	YEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Length:	31
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P05067
UniProt Name:	A4_HUMAN
Protein Name:	Amyloid-beta precursor protein (APP)
Position:	681-711

Literature

PMID:	16565054
Reference:	Biophys J. 2006 Jun 15;90(12):4618-29. Epub 2006 Mar 24.
source:	AmyLoad

Derived Information

Net Charge:	-1
Absolute Charge:	5
Hydrophobicity:	51.61
NuAPRpred:	3.95
Tango:	871.37

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	15.6
Area of the profile Above Threshold (AGGRESCAN):	10.87
Best Energy Score (PASTA 2.0):	-6.89
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1963
Peptide:	FHVNLLCGEEQGSDAALHFNPRLDTSEVVFNS
Length:	32
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	33-64

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-4
Absolute Charge:	6
Hydrophobicity:	43.75
NuAPRpred:	-2.72
Tango:	4.13

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-12.0
Area of the profile Above Threshold (AGGRESCAN):	5.43
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1964
Peptide:	HVNLLCGEEQGSDAALHFNPRLDTSEVVFNSK
Length:	32
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	34-65

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-3
Absolute Charge:	7
Hydrophobicity:	40.62
NuAPRpred:	-3.44
Tango:	20.82

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-16.6
Area of the profile Above Threshold (AGGRESCAN):	4.81
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1965
Peptide:	FHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSK
Length:	33
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	33-65

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-3
Absolute Charge:	7
Hydrophobicity:	42.42
NuAPRpred:	-2.53
Tango:	12.23

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-14.2
Area of the profile Above Threshold (AGGRESCAN):	5.3
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Sequence

1

M

A

G

P

L

R

A

P

L

A

I

L

A

V

A

L

A

V

S

P

A

G

S

P

G

K

P

R

L

V

G

P

M

D

A

S

V

E

G

V

R

A

L

D

F

A

V

G

E

Y

60

61

N

K

A

S

N

D

M

Y

H

S

R

A

L

Q

V

R

A

R

K

Q

I

V

A

G

V

N

Y

F

L

D

V

E

L

G

R

T

C

T

K

T

Q

P

N

L

D

N

C

P

F

H

D

Q

P

H

L

K

R

K

120

121

A

F

C

S

F

Q

I

Y

A

V

P

W

Q

G

T

M

T

L

S

K

S

T

C

Q

D

A

146

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1966
Peptide:	YHSRALQVVRARKQIVAGVNYFLDVELGRTTCT
Length:	33
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P01034
UniProt Name:	CYTC_HUMAN
Protein Name:	Cystatin-C
Position:	68-100

Literature

PMID:	11276250
Reference:	Nat Struct Biol. 2001 Apr;8(4):316-20.
source:	CPAD

Derived Information

Net Charge:	3
Absolute Charge:	7
Hydrophobicity:	48.48
NuAPRpred:	-2.33
Tango:	637.58

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	3.2
Area of the profile Above Threshold (AGGRESCAN):	6.69
Best Energy Score (PASTA 2.0):	-6.72
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

A

G

P

L

R

A

P

L

A

I

L

A

V

A

L

A

V

S

P

A

G

S

P

G

K

P

R

L

V

G

P

M

D

A

S

V

E

G

V

R

A

L

D

F

A

V

G

E

Y

60

61

N

K

A

S

N

D

M

Y

H

S

R

A

L

Q

V

R

A

R

K

Q

I

V

A

G

V

N

Y

F

L

D

V

E

L

G

R

T

C

T

K

T

Q

P

N

L

D

N

C

P

F

H

D

Q

P

H

L

K

R

K

120

121

A

F

C

S

F

Q

I

Y

A

V

P

W

Q

G

T

M

T

L

S

K

S

T

C

Q

D

A

146

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1967
Peptide:	YHSRALQVVRARKQIVAGVNYFLDVEQGRTTCT
Length:	33
Classification:	Amyloid
Mutation(s):	L94Q
Structure(s):	No structures

Protein Information

UniProt ID:	P01034
UniProt Name:	CYTC_HUMAN
Protein Name:	Cystatin-C
Position:	68-100

Literature

PMID:	11276250
Reference:	Nat Struct Biol. 2001 Apr;8(4):316-20.
source:	CPAD

Derived Information

Net Charge:	3
Absolute Charge:	7
Hydrophobicity:	45.45
NuAPRpred:	-3.26
Tango:	637.91

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-4.7
Area of the profile Above Threshold (AGGRESCAN):	6.45
Best Energy Score (PASTA 2.0):	-6.72
Aggregate Orientation (PASTA 2.0):	Parallel

Peptide details

Entry:	P-1968
Peptide:	EASNCFAIRHFENKFAVETLICFNLFLNSQEKHY
Length:	34
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:
Protein Name:
Position:

Literature

PMID:	16537487
Reference:	Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:	CPAD, AmyLoad

Derived Information

Net Charge:	-1
Absolute Charge:	7
Hydrophobicity:	50.0
NuAPRpred:	6.78
Tango:	597.48

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	3.2
Area of the profile Above Threshold (AGGRESCAN):	10.11
Best Energy Score (PASTA 2.0):	-6.15
Aggregate Orientation (PASTA 2.0):	Parallel

Peptide details

Entry:	P-1969
Peptide:	EASNCFAIRHFENKFAVETLICSRTVKKNIIEEN
Length:	34
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:
Protein Name:
Position:

Literature

PMID:	16537487
Reference:	Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:	CPAD, AmyLoad

Derived Information

Net Charge:	0
Absolute Charge:	10
Hydrophobicity:	44.12
NuAPRpred:	3.14
Tango:	5.66

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-2.5
Area of the profile Above Threshold (AGGRESCAN):	5.97
Best Energy Score (PASTA 2.0):	-4.3
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

N

I

K

G

S

P

W

K

G

S

L

V

S

N

L

C

Q

S

V

A

P

L

P

I

C

P

G

A

R

C

Q

V

T

L

R

D

L

F

D

R

A

V

L

S

H

Y

I

H

N

L

60

61

S

E

M

F

S

E

F

D

K

R

Y

T

H

G

R

G

F

I

T

K

A

I

N

S

C

H

T

S

L

A

T

P

E

D

K

E

Q

A

Q

M

N

Q

K

D

F

L

S

L

I

V

S

I

L

R

S

W

N

120

121

E

P

L

Y

H

L

V

T

E

V

R

G

M

Q

E

A

P

E

A

I

L

S

K

A

V

E

I

E

Q

T

K

R

L

E

G

M

E

L

I

V

S

Q

V

H

P

E

T

K

E

N

E

I

Y

P

V

W

S

G

180

181

L

P

S

L

Q

M

A

D

E

S

R

L

S

A

Y

N

L

H

C

L

R

D

S

H

K

I

D

N

Y

L

K

L

K

C

R

I

H

N

C

227

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1970
Peptide:	LPICPGGAARCQTVLRDLFDRAVVLSHYIHNLSS
Length:	34
Classification:	Amyloid
Mutation(s):	V41T, T42V
Structure(s):	No structures

Protein Information

UniProt ID:	P01236
UniProt Name:	PRL_HUMAN
Protein Name:	Prolactin (PRL)
Position:	29-62

Literature

PMID:	9006656
Reference:	Acta Neuropathol. 1997 Jan;93(1):43-9.
source:	AmyLoad

Derived Information

Net Charge:	1
Absolute Charge:	5
Hydrophobicity:	55.88
NuAPRpred:	-2.53
Tango:	177.6

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	8.9
Area of the profile Above Threshold (AGGRESCAN):	6.88
Best Energy Score (PASTA 2.0):	-7.07
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

D

V

G

S

K

E

V

L

M

E

S

P

D

Y

S

A

P

R

G

R

F

G

I

P

C

P

V

H

L

K

R

L

I

V

L

I

V

I

V

G

A

L

M

G

L

H

M

60

61

S

Q

K

H

T

E

M

V

L

E

M

S

I

G

A

P

E

A

Q

R

L

A

L

S

E

H

L

V

T

A

T

F

S

I

G

S

T

G

L

V

Y

D

Y

Q

L

I

A

Y

K

P

A

P

G

T

C

120

121

C

Y

I

M

K

I

A

P

E

S

I

P

S

L

E

A

L

N

R

K

V

H

N

F

Q

M

E

C

S

L

Q

A

K

P

A

V

P

T

S

K

L

G

Q

A

E

G

R

D

A

G

S

A

P

S

G

D

P

A

F

180

181

L

G

M

A

V

N

T

L

C

G

E

V

P

L

Y

I

197

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1971
Peptide:	FGIPCCPVHLKRLLIVVVVVVLVVVVIVGALLMGL
Length:	35
Classification:	Amyloid
Mutation(s):	L46V
Structure(s):	No structures

Protein Information

UniProt ID:	P11686
UniProt Name:	PSPC_HUMAN
Protein Name:	Pulmonary surfactant-associated protein C (SP-C)
Position:	24-58

Literature

PMID:	14770296
Reference:	Cell Mol Life Sci. 2004 Feb;61(3):326-35.
source:	AmyLoad

Derived Information

Net Charge:	2
Absolute Charge:	2
Hydrophobicity:	82.86
NuAPRpred:	17.46
Tango:	1622.03

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	87.7
Area of the profile Above Threshold (AGGRESCAN):	30.85
Best Energy Score (PASTA 2.0):	-28.35
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1972
Peptide:	FHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQ
Length:	35
Classification:	Non-amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	33-67

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-4
Absolute Charge:	8
Hydrophobicity:	40.0
NuAPRpred:	-3.2
Tango:	7.47

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-21.1
Area of the profile Above Threshold (AGGRESCAN):	5.3
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1973
Peptide:	RFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKE
Length:	35
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	32-66

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-3
Absolute Charge:	9
Hydrophobicity:	40.0
NuAPRpred:	-2.86
Tango:	3.2

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-18.3
Area of the profile Above Threshold (AGGRESCAN):	5.3
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1974
Peptide:	SRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSK
Length:	35
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	31-65

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-2
Absolute Charge:	8
Hydrophobicity:	40.0
NuAPRpred:	-2.97
Tango:	9.02

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-15.2
Area of the profile Above Threshold (AGGRESCAN):	5.48
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Peptide details

Entry:	P-1975
Peptide:	IRKRYRKFLNESYKHEQVYIRSTDVDRTLMSAMTNL
Length:	36
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:
Protein Name:
Position:

Literature

PMID:
Reference:
source:	CPAD

Derived Information

Net Charge:	4
Absolute Charge:	12
Hydrophobicity:	38.89
NuAPRpred:	-9.72
Tango:	0.0

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-15.7
Area of the profile Above Threshold (AGGRESCAN):	3.82
Best Energy Score (PASTA 2.0):	-3.44
Aggregate Orientation (PASTA 2.0):	Antiparallel

Peptide details

Entry:	P-1976
Peptide:	KPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDF
Length:	36
Classification:	Non-amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:	P10636
UniProt Name:	TAU_HUMAN
Protein Name:	Microtubule-associated protein tau (PHF-tau)
Position:

Literature

PMID:	10805776
Reference:	Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:	AmyLoad

Derived Information

Net Charge:	2
Absolute Charge:	10
Hydrophobicity:	33.33
NuAPRpred:	-5.94
Tango:	0.0

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-22.8
Area of the profile Above Threshold (AGGRESCAN):	1.33
Best Energy Score (PASTA 2.0):	-1.79
Aggregate Orientation (PASTA 2.0):	Parallel

Peptide details

Entry:	P-1977
Peptide:	QTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIVY
Length:	36
Classification:	Non-amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:	P10636
UniProt Name:	TAU_HUMAN
Protein Name:	Microtubule-associated protein tau (PHF-tau)
Position:

Literature

PMID:	10805776
Reference:	Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:	AmyLoad

Derived Information

Net Charge:	3
Absolute Charge:	7
Hydrophobicity:	41.67
NuAPRpred:	-10.74
Tango:	0.0

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-17.9
Area of the profile Above Threshold (AGGRESCAN):	3.38
Best Energy Score (PASTA 2.0):	-4.98
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

S

N

V

P

H

K

S

L

P

E

G

I

R

P

G

T

V

L

R

I

R

G

L

V

P

N

A

S

R

F

H

V

N

L

C

G

E

Q

G

S

D

A

L

H

F

N

P

R

L

D

T

S

E

V

60

61

V

F

N

S

K

E

Q

G

S

W

G

R

E

R

G

P

G

V

P

F

Q

R

G

Q

P

F

E

V

L

I

A

S

D

G

F

K

A

V

G

D

A

Q

Y

H

F

R

H

R

L

P

L

A

R

V

R

120

121

L

V

E

V

G

D

V

Q

L

D

S

V

R

I

F

136

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1978
Peptide:	SRFHVNLLCGEEQGSDAALHFNPRLDTSEVVFNSKEQ
Length:	37
Classification:	Amyloid
Mutation(s):	No
Structure(s):	No structures

Protein Information

UniProt ID:	P47929
UniProt Name:	LEG7_HUMAN
Protein Name:	Galectin-7
Position:	31-67

Literature

PMID:	25172508
Reference:	J Biol Chem. 2014 Oct 17;289(42):29195-207
source:	CPAD

Derived Information

Net Charge:	-3
Absolute Charge:	9
Hydrophobicity:	37.84
NuAPRpred:	-3.64
Tango:	4.08

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-21.7
Area of the profile Above Threshold (AGGRESCAN):	5.48
Best Energy Score (PASTA 2.0):	-4.88
Aggregate Orientation (PASTA 2.0):	-

Peptide details

Entry:	P-1979
Peptide:	GIHKQKEKSRLQGGVLVNEILNHMKRATQIPSYKKLIMY
Length:	39
Classification:	Amyloid
Mutation(s):
Structure(s):	No structures

Protein Information

UniProt ID:
UniProt Name:
Protein Name:
Position:

Literature

PMID:
Reference:
source:	CPAD

Derived Information

Net Charge:	6
Absolute Charge:	10
Hydrophobicity:	41.03
NuAPRpred:	-2.02
Tango:	2.61

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	-9.3
Area of the profile Above Threshold (AGGRESCAN):	7.26
Best Energy Score (PASTA 2.0):	-4.92
Aggregate Orientation (PASTA 2.0):	Parallel

Sequence

1

M

L

P

G

L

A

L

A

W

T

A

R

A

L

E

V

P

T

D

G

N

A

G

L

A

E

P

Q

I

A

M

F

C

G

R

L

N

M

H

M

N

V

Q

N

G

K

W

D

S

D

P

S

G

T

K

60

61

T

C

I

D

T

K

E

G

I

L

Q

Y

C

Q

E

V

Y

P

E

L

Q

I

T

N

V

E

A

N

Q

P

V

T

I

Q

N

W

C

K

R

G

R

K

Q

C

K

T

H

P

H

F

V

I

P

Y

R

C

L

V

G

120

121

E

F

V

S

D

A

L

V

P

D

K

C

K

F

L

H

Q

E

R

M

D

V

C

E

T

H

L

H

W

H

T

V

A

K

E

T

C

S

E

K

S

T

N

L

H

D

Y

G

M

L

P

C

G

I

D

K

F

R

180

181

G

V

E

F

V

C

P

L

A

E

S

D

N

V

D

S

A

D

A

E

D

S

D

V

W

G

A

D

T

D

Y

A

D

G

S

E

D

K

V

E

V

A

E

V

A

E

V

E

240

241

E

A

D

E

D

E

D

G

D

E

V

E

A

E

P

Y

E

A

T

E

R

T

S

I

A

T

E

S

V

E

V

R

E

V

C

S

E

Q

A

E

T

G

P

C

300

301

R

A

M

I

S

R

W

Y

F

D

V

T

E

G

K

C

A

P

F

Y

G

C

G

N

R

N

F

D

T

E

Y

C

M

A

V

C

G

S

A

M

S

Q

S

L

K

T

Q

E

P

L

A

R

D

360

361

P

V

K

L

P

T

A

S

T

P

D

A

V

D

K

Y

L

E

T

P

G

D

E

N

E

H

A

H

F

Q

K

A

K

E

R

L

E

A

K

H

R

E

R

M

S

Q

V

M

R

E

W

E

A

E

R

Q

A

420

421

K

N

L

P

K

A

D

K

A

V

I

Q

H

F

Q

E

K

V

E

S

L

E

Q

E

A

N

E

R

Q

L

V

E

T

H

M

A

R

V

E

A

M

L

N

D

R

L

A

L

E

N

Y

I

T

A

L

480

481

Q

A

V

P

R

P

R

H

V

F

N

M

L

K

Y

V

R

A

E

Q

K

D

R

Q

H

T

L

K

H

F

E

H

V

R

M

V

D

P

K

A

Q

I

R

S

Q

V

M

T

H

L

R

V

I

Y

E

R

540

541

M

N

Q

S

L

S

L

Y

N

V

P

A

V

A

E

I

Q

D

E

V

D

E

L

Q

K

E

Q

N

Y

S

D

V

L

A

N

M

I

S

E

P

R

I

S

Y

G

N

D

A

L

M

P

S

L

T

E

T

600

601

K

T

V

E

L

P

V

N

G

E

F

S

L

D

L

Q

P

W

H

S

F

G

A

D

S

V

P

A

N

T

E

N

E

V

E

P

V

D

A

R

P

A

D

R

G

L

T

R

P

G

S

G

L

T

N

660

661

I

K

T

E

I

S

E

V

K

M

D

A

E

F

R

H

D

S

G

Y

E

V

H

Q

K

L

V

F

A

E

D

V

G

S

N

K

G

A

I

G

L

M

V

G

V

I

A

T

V

I

V

I

T

L

720

721

V

M

L

K

Q

Y

T

S

I

H

G

V

E

V

D

A

V

T

P

E

R

H

L

S

K

M

Q

N

G

Y

E

N

P

T

Y

K

F

E

Q

M

Q

N

770

Amyloidogenic/non-amyloidogenic residues are highlighed in green background.

Charged and Proline residues are highlighed in light red.

Peptide details

Entry:	P-1980
Peptide:	DAAFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Length:	40
Classification:	Amyloid
Mutation(s):	E674A
Structure(s):	No structures

Protein Information

UniProt ID:	P05067
UniProt Name:	A4_HUMAN
Protein Name:	Amyloid-beta precursor protein (APP)
Position:	672-711

Literature

PMID:	18258258
Reference:	J Mol Biol. 2008 Mar 21;377(2):565-74.
source:	CPAD

Derived Information

Net Charge:	-2
Absolute Charge:	8
Hydrophobicity:	47.5
NuAPRpred:	-0.05
Tango:	875.77

Derived Information (continued)

Normalized Aggregation Propensity (AGGRESCAN):	3.1
Area of the profile Above Threshold (AGGRESCAN):	10.99
Best Energy Score (PASTA 2.0):	-6.89
Aggregate Orientation (PASTA 2.0):	Parallel

Database of known aggregating/non-aggregating peptides

Displaying 1951 to 1980 records out of 2031 records fetched.