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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1921 to 1950 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1921
LSKVTSKCGSLGNIHHKPGGGQVE
24
Non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
AmyLoad
P-1922
LVFFAEDVGSNKGAIIGLMVGGVV
24
Amyloid
Amyloid-beta precursor protein (APP)
P05068
No
Chem Res Toxicol. 2013 Feb 18;26(2):262-9
23289528
CPAD
P-1923
PHKSSLPEGIRPGTVLRIRGLVPP
24
Non-amyloid
Galectin-7
P47929
No
J Biol Chem. 2014 Oct 17;289(42):29195-207
25172508
CPAD
P-1924
SAPNLATLVKVTTNHFTHEEAMMD
24
Amyloid
Myohemerythrin (MHr)
P02247
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
CPAD, AmyLoad
P-1925
GAAGLGGLGVGGLGVPGVGGLGGLV
25
Amyloid
J Biol Chem. 2005 Jan 28;280(4):2682-90.
15550396
AmyLoad
P-1926
GLVGAAGLGGLGVGGLGVPGVGGLG
25
Amyloid
Elastin (Tropoelastin)
P15502
No
Biomacromolecules. 2007 Nov;8(11):3478-86.
17929969
CPAD
P-1927
HDSGYEVHHQKLVFFAEDVGSNKGA
25
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1928
IKNESKASNTFINNAANMSIRRSMA
25
Amyloid
Merozoite surface protein 2
Q94673
T27A
Biopolymers. 2007 Sep;87(1):12-22
17516503
CPAD
P-1929
IKNESKYSNTFINNAYNMSIRRSMA
25
Amyloid
Merozoite surface protein 2 (Fragment)
Q94673
T27A
J Pept Sci. 2007 Dec;13(12):839-48.
17883245
CPAD
P-1930
KGTFEKATSEAYAYADTLKKDNGEY
25
Amyloid
Protein Sci. 1997 Jan;6(1):162-74.
9007989
CPAD, AmyLoad
P-1931
YEAGKEKYVKELPEHLKPFETLLSQ
25
Non-amyloid
Glutathione S-transferase P
P80031
No
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
11370666
AmyLoad
P-1932
AVRLSLGAQNLASSQIQRNPVLITLG
26
Amyloid
Blood. 1997 Dec 15;90(12):4799-805.
9389696
CPAD
P-1933
CHQKLVFFAEDYNGKDEAFFVLKQHW
26
Amyloid
synthetic
Biophys Chem. 2006 Mar 1;120(1):55-61.
16288953
CPAD
P-1934
CHQKLVFFAEDYNGKHQKLVFFAEDC
26
Amyloid
Biochem J. 2002 Aug 15;366(Pt 1):343-51.
12023906
CPAD
P-1935
CHQKLVFFAEDYNGKHQKLVFFAEDW
26
Amyloid
synthetic
Biophys Chem. 2006 Mar 1;120(1):55-61.
16288953
CPAD
P-1936
KLDFKDRVQSKIGSLDNITHVPGGGN
26
Non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
AmyLoad
P-1937
SRFHVNLLCGEEQGSDAALHFNPRLD
26
Non-amyloid
Galectin-7
P47929
No
J Biol Chem. 2014 Oct 17;289(42):29195-207
25172508
CPAD
P-1938
DILTLLNSTNKDWWKVEVNDRQGFVPA
27
Amyloid
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Q13813
No
J Mol Biol. 1996 Jan 26;255(3):507-21.
8568894
CPAD, AmyLoad
P-1939
CHQKLVFFAEDDYNGKHQKLVFFAEDSC
28
Amyloid
Biochem J. 2002 Aug 15;366(Pt 1):343-51.
12023906
CPAD
P-1940
DAEFRHDSGYEVHHQKLVFFAEDVGSNK
28
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10940-4.
1438300
CPAD
P-1941
DQKEAALVDMVNDGVEDLRCKYATLIYT
28
Non-amyloid
Glutathione S-transferase P
P80031
No
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
11370666
AmyLoad
P-1942
ETDVKMMERVVEQMCVTQYQKESQAYYD
28
Amyloid
Major prion protein (PrP)
P04156
No
Biochemistry. 2008 Dec 16;47(50):13242-51.
19053276
CPAD
P-1943
KPFIARFEGRLFSRSDELKAIIKELTGE
28
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1944
KPFLARFRGRIFSRSDELRTLIAAFTGE
28
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1945
KPFLARVEGRIFSRSDELRAYITAYTGE
28
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1946
KPFTARFEGRIFSRSDELRALITEITGE
28
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1947
KPFTARISGRLFSRSDELKTIIATITGE
28
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1948
KPYIARFEGRLFSRSDELRAVIEAHTGE
28
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1949
VHHQKLVFFAEDVGSNKAIIGLMVGGVV
28
Amyloid
Amyloid-beta precursor protein (APP)
P05067
[del]700G
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
P-1950
EPEITLIIFGVMAGVIGTILLISYGIRRL
29
Amyloid
Glycophorin-A (MN sialoglycoprotein)
P02724
No
Biochemistry. 2005 Mar 8;44(9):3591-7.
15736968
AmyLoad
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Entry: P-1921 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1921
Peptide:
LSKVTSKCGSLGNIHHKPGGGQVE
Length:
24
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
29.17
NuAPRpred:
-3.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.3
Area of the profile Above Threshold (AGGRESCAN):
1.17
Best Energy Score (PASTA 2.0):
-1.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1922 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
40
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1922
Peptide:
LVFFAEDVGSNKGAIIGLMVGGVV
Length:
24
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05068
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
17-40
Literature
PMID:
23289528
Reference:
Chem Res Toxicol. 2013 Feb 18;26(2):262-9
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
58.33
NuAPRpred:
1.73
Tango:
481.04
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
31.7
Area of the profile Above Threshold (AGGRESCAN):
11.68
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1923 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
N
V
P
H
K
S
S
L
P
E
G
I
R
P
G
T
V
L
R
I
R
G
L
V
P
P
N
A
S
R
F
H
V
N
L
L
C
G
E
E
Q
G
S
D
A
A
L
H
F
N
P
R
L
D
T
S
E
V
60
61
V
F
N
S
K
E
Q
G
S
W
G
R
E
E
R
G
P
G
V
P
F
Q
R
G
Q
P
F
E
V
L
I
I
A
S
D
D
G
F
K
A
V
V
G
D
A
Q
Y
H
H
F
R
H
R
L
P
L
A
R
V
R
120
121
L
V
E
V
G
G
D
V
Q
L
D
S
V
R
I
F
136
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1923
Peptide:
PHKSSLPEGIRPGTVLRIRGLVPP
Length:
24
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P47929
UniProt Name:
LEG7_HUMAN
Protein Name:
Galectin-7
Position:
5-28
Literature
PMID:
25172508
Reference:
J Biol Chem. 2014 Oct 17;289(42):29195-207
source:
CPAD
Derived Information
Net Charge:
3
Absolute Charge:
5
Hydrophobicity:
50.0
NuAPRpred:
-8.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.0
Area of the profile Above Threshold (AGGRESCAN):
3.33
Best Energy Score (PASTA 2.0):
-3.74
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1924 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
G
W
E
I
P
E
P
Y
V
W
D
E
S
F
R
V
F
Y
E
Q
L
D
E
E
H
K
K
I
F
K
G
I
F
D
C
I
R
D
N
S
A
P
N
L
A
T
L
V
K
V
T
T
N
H
F
T
H
E
E
A
60
61
M
M
D
A
A
K
Y
S
E
V
V
P
H
K
K
M
H
K
D
F
L
E
K
I
G
G
L
S
A
P
V
D
A
K
N
V
D
Y
C
K
E
W
L
V
N
H
I
K
G
T
D
F
K
Y
K
G
K
L
118
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1924
Peptide:
SAPNLATLVKVTTNHFTHEEAMMD
Length:
24
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02247
UniProt Name:
HEMTM_THEHE
Protein Name:
Myohemerythrin (MHr)
Position:
40-63
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
45.83
NuAPRpred:
-4.61
Tango:
25.94
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.6
Area of the profile Above Threshold (AGGRESCAN):
3.35
Best Energy Score (PASTA 2.0):
-4.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1925 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1925
Peptide:
GAAGLGGLGVGGLGVPGVGGLGGLV
Length:
25
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
ELN_HUMAN
Protein Name:
Position:
Literature
PMID:
15550396
Reference:
J Biol Chem. 2005 Jan 28;280(4):2682-90.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
48.0
NuAPRpred:
-2.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.7
Area of the profile Above Threshold (AGGRESCAN):
5.33
Best Energy Score (PASTA 2.0):
-0.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1926 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
L
T
A
A
A
P
R
P
G
V
L
L
L
L
L
S
I
L
H
P
S
R
P
G
G
V
P
G
A
I
P
G
G
V
P
G
G
V
F
Y
P
G
A
G
L
G
A
L
G
G
G
A
L
G
P
G
G
60
61
K
P
L
K
P
V
P
G
G
L
A
G
A
G
L
G
A
G
L
G
A
F
P
A
V
T
F
P
G
A
L
V
P
G
G
V
A
D
A
A
A
A
Y
K
A
A
K
A
G
A
G
L
G
G
V
P
G
V
G
G
120
121
L
G
V
S
A
G
A
V
V
P
Q
P
G
A
G
V
K
P
G
K
V
P
G
V
G
L
P
G
V
Y
P
G
G
V
L
P
G
A
R
F
P
G
V
G
V
L
P
G
V
P
T
G
A
G
V
K
P
K
A
P
180
181
G
V
G
G
A
F
A
G
I
P
G
V
G
P
F
G
G
P
Q
P
G
V
P
L
G
Y
P
I
K
A
P
K
L
P
G
G
Y
G
L
P
Y
T
T
G
K
L
P
Y
G
Y
G
P
G
G
V
A
G
A
A
G
240
241
K
A
G
Y
P
T
G
T
G
V
G
P
Q
A
A
A
A
A
A
A
K
A
A
A
K
F
G
A
G
A
A
G
V
L
P
G
V
G
G
A
G
V
P
G
V
P
G
A
I
P
G
I
G
G
I
A
G
V
G
T
300
301
P
A
A
A
A
A
A
A
A
A
A
K
A
A
K
Y
G
A
A
A
G
L
V
P
G
G
P
G
F
G
P
G
V
V
G
V
P
G
A
G
V
P
G
V
G
V
P
G
A
G
I
P
V
V
P
G
A
G
I
P
360
361
G
A
A
V
P
G
V
V
S
P
E
A
A
A
K
A
A
A
K
A
A
K
Y
G
A
R
P
G
V
G
V
G
G
I
P
T
Y
G
V
G
A
G
G
F
P
G
F
G
V
G
V
G
G
I
P
G
V
A
G
V
420
421
P
G
V
G
G
V
P
G
V
G
G
V
P
G
V
G
I
S
P
E
A
Q
A
A
A
A
A
K
A
A
K
Y
G
A
A
G
A
G
V
L
G
G
L
V
P
G
A
P
G
A
V
P
G
V
P
G
T
G
G
V
480
481
P
G
V
G
T
P
A
A
A
A
A
K
A
A
A
K
A
A
Q
F
G
L
V
P
G
V
G
V
A
P
G
V
G
V
A
P
G
V
G
V
A
P
G
V
G
L
A
P
G
V
G
V
A
P
G
V
G
V
A
P
540
541
G
V
G
V
A
P
G
I
G
P
G
G
V
A
A
A
A
K
S
A
A
K
V
A
A
K
A
Q
L
R
A
A
A
G
L
G
A
G
I
P
G
L
G
V
G
V
G
V
P
G
L
G
V
G
A
G
V
P
G
L
600
601
G
V
G
A
G
V
P
G
F
G
A
G
A
D
E
G
V
R
R
S
L
S
P
E
L
R
E
G
D
P
S
S
S
Q
H
L
P
S
T
P
S
S
P
R
V
P
G
A
L
A
A
A
K
A
A
K
Y
G
A
A
660
661
V
P
G
V
L
G
G
L
G
A
L
G
G
V
G
I
P
G
G
V
V
G
A
G
P
A
A
A
A
A
A
A
K
A
A
A
K
A
A
Q
F
G
L
V
G
A
A
G
L
G
G
L
G
V
G
G
L
G
V
P
720
721
G
V
G
G
L
G
G
I
P
P
A
A
A
A
K
A
A
K
Y
G
A
A
G
L
G
G
V
L
G
G
A
G
Q
F
P
L
G
G
V
A
A
R
P
G
F
G
L
S
P
I
F
P
G
G
A
C
L
G
K
A
780
781
C
G
R
K
R
K
786
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1926
Peptide:
GLVGAAGLGGLGVGGLGVPGVGGLG
Length:
25
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P15502
UniProt Name:
ELN_HUMAN
Protein Name:
Elastin (Tropoelastin)
Position:
702-726
Literature
PMID:
17929969
Reference:
Biomacromolecules. 2007 Nov;8(11):3478-86.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
48.0
NuAPRpred:
-2.85
Tango:
3.25
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
18.0
Area of the profile Above Threshold (AGGRESCAN):
5.22
Best Energy Score (PASTA 2.0):
-0.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1927 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1927
Peptide:
HDSGYEVHHQKLVFFAEDVGSNKGA
Length:
25
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
677-701
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
6
Hydrophobicity:
36.0
NuAPRpred:
-1.28
Tango:
432.73
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.9
Area of the profile Above Threshold (AGGRESCAN):
3.94
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1928 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
F
N
I
K
N
E
S
K
Y
S
N
T
F
I
N
N
A
Y
N
M
S
I
R
R
S
M
T
E
S
N
P
P
T
G
A
S
G
S
A
G
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
60
61
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
120
121
S
G
A
D
A
E
R
S
P
S
T
P
A
T
T
T
T
T
T
T
T
N
D
A
E
A
S
T
S
T
S
S
E
N
P
N
H
N
N
A
K
T
N
P
K
G
N
G
G
V
Q
E
P
N
Q
A
176
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1928
Peptide:
IKNESKASNTFINNAANMSIRRSMA
Length:
25
Classification:
Amyloid
Mutation(s):
T27A
Structure(s):
No structures
Protein Information
UniProt ID:
Q94673
UniProt Name:
Q94673_PLAFA
Protein Name:
Merozoite surface protein 2
Position:
1-25
Literature
PMID:
17516503
Reference:
Biopolymers. 2007 Sep;87(1):12-22
source:
CPAD
Derived Information
Net Charge:
3
Absolute Charge:
5
Hydrophobicity:
40.0
NuAPRpred:
-5.72
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-28.1
Area of the profile Above Threshold (AGGRESCAN):
1.23
Best Energy Score (PASTA 2.0):
-3.36
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1929 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
F
N
I
K
N
E
S
K
Y
S
N
T
F
I
N
N
A
Y
N
M
S
I
R
R
S
M
T
E
S
N
P
P
T
G
A
S
G
S
A
G
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
60
61
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
120
121
S
G
A
D
A
E
R
S
P
S
T
P
A
T
T
T
T
T
T
T
T
N
D
A
E
A
S
T
S
T
S
S
E
N
P
N
H
N
N
A
K
T
N
P
K
G
N
G
G
V
Q
E
P
N
Q
A
176
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1929
Peptide:
IKNESKYSNTFINNAYNMSIRRSMA
Length:
25
Classification:
Amyloid
Mutation(s):
T27A
Structure(s):
No structures
Protein Information
UniProt ID:
Q94673
UniProt Name:
Q94673_PLAFA
Protein Name:
Merozoite surface protein 2 (Fragment)
Position:
3-27
Literature
PMID:
17883245
Reference:
J Pept Sci. 2007 Dec;13(12):839-48.
source:
CPAD
Derived Information
Net Charge:
3
Absolute Charge:
5
Hydrophobicity:
40.0
NuAPRpred:
-3.81
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.5
Area of the profile Above Threshold (AGGRESCAN):
1.91
Best Energy Score (PASTA 2.0):
-4.3
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1930 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1930
Peptide:
KGTFEKATSEAYAYADTLKKDNGEY
Length:
25
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
PL B1 protein
Protein Name:
Position:
Literature
PMID:
9007989
Reference:
Protein Sci. 1997 Jan;6(1):162-74.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
9
Hydrophobicity:
36.0
NuAPRpred:
-8.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.0
Area of the profile Above Threshold (AGGRESCAN):
0.87
Best Energy Score (PASTA 2.0):
-1.98
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1931 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
P
P
Y
T
I
T
Y
F
P
V
R
G
R
C
E
A
M
R
M
L
L
A
D
Q
D
Q
S
W
K
E
E
V
V
T
M
E
T
W
P
P
L
K
P
S
C
L
F
R
Q
L
P
K
F
Q
D
G
D
L
T
L
60
61
Y
Q
S
N
A
I
L
R
H
L
G
R
S
F
G
L
Y
G
K
D
Q
K
E
A
A
L
V
D
M
V
N
D
G
V
E
D
L
R
C
K
Y
A
T
L
I
Y
T
N
Y
E
A
G
K
E
K
Y
V
K
E
L
120
121
P
E
H
L
K
P
F
E
T
L
L
S
Q
N
Q
G
G
Q
A
F
V
V
G
S
Q
I
S
F
A
D
Y
N
L
L
D
L
L
R
I
H
Q
V
L
N
P
S
C
L
D
A
F
P
L
L
S
A
Y
V
A
R
180
181
L
S
A
R
P
K
I
K
A
F
L
A
S
P
E
H
V
N
R
P
I
N
G
N
G
K
N
207
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1931
Peptide:
YEAGKEKYVKELPEHLKPFETLLSQ
Length:
25
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P80031
UniProt Name:
GSTP1_PIG
Protein Name:
Glutathione S-transferase P
Position:
109-133
Literature
PMID:
11370666
Reference:
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
9
Hydrophobicity:
44.0
NuAPRpred:
-7.71
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-16.4
Area of the profile Above Threshold (AGGRESCAN):
2.07
Best Energy Score (PASTA 2.0):
-2.29
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1932 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1932
Peptide:
AVRLSLGAQNLASSQIQRNPVLITLG
Length:
26
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
9389696
Reference:
Blood. 1997 Dec 15;90(12):4799-805.
source:
CPAD
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-6.93
Tango:
330.31
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.1
Area of the profile Above Threshold (AGGRESCAN):
5.7
Best Energy Score (PASTA 2.0):
-5.57
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1933 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1933
Peptide:
CHQKLVFFAEDYNGKDEAFFVLKQHW
Length:
26
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
synthetic
UniProt Name:
A4_HUMAN
Protein Name:
Position:
Literature
PMID:
16288953
Reference:
Biophys Chem. 2006 Mar 1;120(1):55-61.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
7
Hydrophobicity:
50.0
NuAPRpred:
0.6
Tango:
870.38
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.4
Area of the profile Above Threshold (AGGRESCAN):
7.58
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1934 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1934
Peptide:
CHQKLVFFAEDYNGKHQKLVFFAEDC
Length:
26
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
12023906
Reference:
Biochem J. 2002 Aug 15;366(Pt 1):343-51.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
7
Hydrophobicity:
50.0
NuAPRpred:
1.95
Tango:
869.63
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.1
Area of the profile Above Threshold (AGGRESCAN):
7.58
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1935 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1935
Peptide:
CHQKLVFFAEDYNGKHQKLVFFAEDW
Length:
26
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
synthetic
UniProt Name:
A4_HUMAN
Protein Name:
Position:
Literature
PMID:
16288953
Reference:
Biophys Chem. 2006 Mar 1;120(1):55-61.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
7
Hydrophobicity:
50.0
NuAPRpred:
1.88
Tango:
869.42
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.1
Area of the profile Above Threshold (AGGRESCAN):
7.58
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1936 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1936
Peptide:
KLDFKDRVQSKIGSLDNITHVPGGGN
Length:
26
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
7
Hydrophobicity:
30.77
NuAPRpred:
-7.81
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.6
Area of the profile Above Threshold (AGGRESCAN):
1.25
Best Energy Score (PASTA 2.0):
-3.97
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1937 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
N
V
P
H
K
S
S
L
P
E
G
I
R
P
G
T
V
L
R
I
R
G
L
V
P
P
N
A
S
R
F
H
V
N
L
L
C
G
E
E
Q
G
S
D
A
A
L
H
F
N
P
R
L
D
T
S
E
V
60
61
V
F
N
S
K
E
Q
G
S
W
G
R
E
E
R
G
P
G
V
P
F
Q
R
G
Q
P
F
E
V
L
I
I
A
S
D
D
G
F
K
A
V
V
G
D
A
Q
Y
H
H
F
R
H
R
L
P
L
A
R
V
R
120
121
L
V
E
V
G
G
D
V
Q
L
D
S
V
R
I
F
136
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1937
Peptide:
SRFHVNLLCGEEQGSDAALHFNPRLD
Length:
26
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P47929
UniProt Name:
LEG7_HUMAN
Protein Name:
Galectin-7
Position:
31-56
Literature
PMID:
25172508
Reference:
J Biol Chem. 2014 Oct 17;289(42):29195-207
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
6
Hydrophobicity:
42.31
NuAPRpred:
-1.73
Tango:
0.79
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.0
Area of the profile Above Threshold (AGGRESCAN):
3.19
Best Energy Score (PASTA 2.0):
-4.37
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1938 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
P
S
G
V
K
V
L
E
T
A
E
D
I
Q
E
R
R
Q
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Y
H
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R
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F
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A
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E
L
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60
61
Q
E
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N
Y
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N
L
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H
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A
F
E
A
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V
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A
N
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G
A
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K
L
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T
G
N
L
M
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120
121
R
T
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L
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W
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L
L
L
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M
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I
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L
L
Q
A
Q
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Y
L
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C
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W
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D
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180
181
L
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K
K
F
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T
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A
A
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N
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N
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F
A
A
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I
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H
P
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E
E
L
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T
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N
A
A
W
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240
241
K
G
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L
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300
301
E
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A
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C
A
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360
361
Y
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M
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420
421
D
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C
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480
481
N
W
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L
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540
541
M
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L
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W
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N
E
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M
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T
A
T
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600
601
Y
K
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N
L
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V
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H
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A
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A
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N
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Y
A
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A
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L
W
660
661
K
K
L
L
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A
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L
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A
N
Q
Q
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N
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720
721
A
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780
781
A
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N
L
L
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K
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I
A
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R
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840
841
K
A
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N
A
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A
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D
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900
901
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A
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960
961
A
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W
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1020
1021
V
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K
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N
L
L
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1080
1081
E
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K
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F
M
L
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A
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K
F
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1140
1141
K
A
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E
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L
K
D
I
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K
V
A
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D
L
E
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L
M
A
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A
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M
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D
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T
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S
A
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L
M
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1200
1201
T
V
A
T
F
N
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I
K
E
L
N
E
R
W
R
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L
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N
Q
A
L
N
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1260
1261
Y
G
H
D
L
A
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V
Q
A
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R
K
H
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G
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1320
1321
W
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A
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1380
1381
H
Q
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M
1440
1441
L
D
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C
L
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L
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A
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N
W
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A
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A
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I
K
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N
V
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1500
1501
I
A
A
L
Q
A
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A
D
Q
L
I
A
A
G
H
Y
A
K
G
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R
N
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L
Q
Q
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V
1560
1561
D
E
I
E
A
W
I
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K
L
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Y
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A
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1620
1621
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A
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A
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K
Q
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N
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D
F
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V
E
A
L
1680
1681
L
A
S
E
D
Y
G
K
D
L
A
S
V
N
N
L
L
K
K
H
Q
L
L
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A
D
I
S
A
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L
K
D
L
N
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A
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L
M
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S
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K
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1740
1741
T
I
N
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K
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A
A
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R
A
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N
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K
K
L
L
V
G
S
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D
Y
G
R
D
L
T
G
V
Q
1800
1801
N
L
R
K
K
H
K
R
L
E
A
E
L
A
A
H
E
P
A
I
Q
G
V
L
D
T
G
K
K
L
S
D
D
N
T
I
G
K
E
E
I
Q
Q
R
L
A
Q
F
V
E
H
W
K
E
L
K
Q
L
A
A
1860
1861
A
R
G
Q
R
L
E
E
S
L
E
Y
Q
Q
F
V
A
N
V
E
E
E
E
A
W
I
N
E
K
M
T
L
V
A
S
E
D
Y
G
D
T
L
A
A
I
Q
G
L
L
K
K
H
E
A
F
E
T
D
F
T
1920
1921
V
H
K
D
R
V
N
D
V
C
T
N
G
Q
D
L
I
K
K
N
N
H
H
E
E
N
I
S
S
K
M
K
G
L
N
G
K
V
S
D
L
E
K
A
A
A
Q
R
K
A
K
L
D
E
N
S
A
F
L
Q
1980
1981
F
N
W
K
A
D
V
V
E
S
W
I
G
E
K
E
N
S
L
K
T
D
D
Y
G
R
D
L
S
S
V
Q
T
L
L
T
K
Q
E
T
F
D
A
G
L
Q
A
F
Q
Q
E
G
I
A
N
I
T
A
L
K
2040
2041
D
Q
L
L
A
A
K
H
V
Q
S
K
A
I
E
A
R
H
A
S
L
M
K
R
W
S
Q
L
L
A
N
S
A
A
R
K
K
K
L
L
E
A
Q
S
H
F
R
K
V
E
D
L
F
L
T
F
A
K
K
A
2100
2101
S
A
F
N
S
W
F
E
N
A
E
E
D
L
T
D
P
V
R
C
N
S
L
E
E
I
K
A
L
R
E
A
H
D
A
F
R
S
S
L
S
S
A
Q
A
D
F
N
Q
L
A
E
L
D
R
Q
I
K
S
F
2160
2161
R
V
A
S
N
P
Y
T
W
F
T
M
E
A
L
E
E
T
W
R
N
L
Q
K
I
I
K
E
R
E
L
E
L
Q
K
E
Q
R
R
Q
E
E
N
D
K
L
R
Q
E
F
A
Q
H
A
N
A
F
H
Q
W
2220
2221
I
Q
E
T
R
T
Y
L
L
D
G
S
C
M
V
E
E
S
G
T
L
E
S
Q
L
E
A
T
K
R
K
H
Q
E
I
R
A
M
R
S
Q
L
K
K
I
E
D
L
G
A
A
M
E
E
A
L
I
L
D
N
2280
2281
K
Y
T
E
H
S
T
V
G
L
A
Q
Q
W
D
Q
L
D
Q
L
G
M
R
M
Q
H
N
L
E
Q
Q
I
Q
A
R
N
T
T
G
V
T
E
E
A
L
K
E
F
S
M
M
F
K
H
F
D
K
D
K
S
2340
2341
G
R
L
N
H
Q
E
F
K
S
C
L
R
S
L
G
Y
D
L
P
M
V
E
E
G
E
P
D
P
E
F
E
A
I
L
D
T
V
D
P
N
R
D
G
H
V
S
L
Q
E
Y
M
A
F
M
I
S
R
E
T
2400
2401
E
N
V
K
S
S
E
E
I
E
S
A
F
R
A
L
S
S
E
G
K
P
Y
V
T
K
E
E
L
Y
Q
N
L
T
R
E
Q
A
D
Y
C
V
S
H
M
K
P
Y
V
D
G
K
G
R
E
L
P
T
A
F
2460
2461
D
Y
V
E
F
T
R
S
L
F
V
N
2472
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1938
Peptide:
DILTLLNSTNKDWWKVEVNDRQGFVPA
Length:
27
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13813
UniProt Name:
SPTN1_HUMAN
Protein Name:
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Position:
992-1018
Literature
PMID:
8568894
Reference:
J Mol Biol. 1996 Jan 26;255(3):507-21.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
7
Hydrophobicity:
44.44
NuAPRpred:
-3.2
Tango:
402.93
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-9.0
Area of the profile Above Threshold (AGGRESCAN):
4.86
Best Energy Score (PASTA 2.0):
-4.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1939 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1939
Peptide:
CHQKLVFFAEDDYNGKHQKLVFFAEDSC
Length:
28
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
12023906
Reference:
Biochem J. 2002 Aug 15;366(Pt 1):343-51.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
46.43
NuAPRpred:
0.91
Tango:
870.06
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.3
Area of the profile Above Threshold (AGGRESCAN):
7.58
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1940 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1940
Peptide:
DAEFRHDSGYEVHHQKLVFFAEDVGSNK
Length:
28
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
672-699
Literature
PMID:
1438300
Reference:
Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10940-4.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
35.71
NuAPRpred:
-3.27
Tango:
434.92
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-25.3
Area of the profile Above Threshold (AGGRESCAN):
3.94
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1941 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
P
P
Y
T
I
T
Y
F
P
V
R
G
R
C
E
A
M
R
M
L
L
A
D
Q
D
Q
S
W
K
E
E
V
V
T
M
E
T
W
P
P
L
K
P
S
C
L
F
R
Q
L
P
K
F
Q
D
G
D
L
T
L
60
61
Y
Q
S
N
A
I
L
R
H
L
G
R
S
F
G
L
Y
G
K
D
Q
K
E
A
A
L
V
D
M
V
N
D
G
V
E
D
L
R
C
K
Y
A
T
L
I
Y
T
N
Y
E
A
G
K
E
K
Y
V
K
E
L
120
121
P
E
H
L
K
P
F
E
T
L
L
S
Q
N
Q
G
G
Q
A
F
V
V
G
S
Q
I
S
F
A
D
Y
N
L
L
D
L
L
R
I
H
Q
V
L
N
P
S
C
L
D
A
F
P
L
L
S
A
Y
V
A
R
180
181
L
S
A
R
P
K
I
K
A
F
L
A
S
P
E
H
V
N
R
P
I
N
G
N
G
K
N
207
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1941
Peptide:
DQKEAALVDMVNDGVEDLRCKYATLIYT
Length:
28
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P80031
UniProt Name:
GSTP1_PIG
Protein Name:
Glutathione S-transferase P
Position:
80-107
Literature
PMID:
11370666
Reference:
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
source:
AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
50.0
NuAPRpred:
-3.02
Tango:
395.15
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-8.8
Area of the profile Above Threshold (AGGRESCAN):
6.42
Best Energy Score (PASTA 2.0):
-3.49
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1942 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
Y
W
L
L
A
L
F
V
T
M
W
T
D
V
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
T
W
G
Q
P
H
60
61
G
G
G
W
G
Q
P
H
G
G
S
W
G
Q
P
H
G
G
S
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
N
Q
W
N
K
P
S
K
P
K
T
N
L
K
H
V
A
G
A
A
A
A
G
A
V
120
121
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
M
I
H
F
G
N
D
W
E
D
R
Y
Y
R
E
N
M
Y
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
S
N
Q
N
N
F
V
H
D
C
V
N
180
181
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
V
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
R
S
S
S
T
V
L
F
S
S
P
P
240
241
V
I
L
L
I
S
F
L
I
F
L
I
V
G
254
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1942
Peptide:
ETDVKMMERVVEQMCVTQYQKESQAYYD
Length:
28
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_MOUSE
Protein Name:
Major prion protein (PrP)
Position:
Literature
PMID:
19053276
Reference:
Biochemistry. 2008 Dec 16;47(50):13242-51.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
9
Hydrophobicity:
42.86
NuAPRpred:
-2.32
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-16.0
Area of the profile Above Threshold (AGGRESCAN):
2.76
Best Energy Score (PASTA 2.0):
-3.63
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1943 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1943
Peptide:
KPFIARFEGRLFSRSDELKAIIKELTGE
Length:
28
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Q8MJM9_9PRIM
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
11
Hydrophobicity:
42.86
NuAPRpred:
-7.96
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.4
Area of the profile Above Threshold (AGGRESCAN):
5.15
Best Energy Score (PASTA 2.0):
-2.86
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1944 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1944
Peptide:
KPFLARFRGRIFSRSDELRTLIAAFTGE
Length:
28
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Q8MJM9_9PRIM
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
3
Absolute Charge:
9
Hydrophobicity:
46.43
NuAPRpred:
-8.43
Tango:
258.33
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
4.4
Area of the profile Above Threshold (AGGRESCAN):
6.39
Best Energy Score (PASTA 2.0):
-2.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1945 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1945
Peptide:
KPFLARVEGRIFSRSDELRAYITAYTGE
Length:
28
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Q8MJM9_9PRIM
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
9
Hydrophobicity:
46.43
NuAPRpred:
-8.67
Tango:
62.89
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.1
Area of the profile Above Threshold (AGGRESCAN):
5.6
Best Energy Score (PASTA 2.0):
-2.64
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1946 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1946
Peptide:
KPFTARFEGRIFSRSDELRALITEITGE
Length:
28
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Q8MJM9_9PRIM
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
10
Hydrophobicity:
39.29
NuAPRpred:
-8.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-7.4
Area of the profile Above Threshold (AGGRESCAN):
4.14
Best Energy Score (PASTA 2.0):
-2.42
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1947 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1947
Peptide:
KPFTARISGRLFSRSDELKTIIATITGE
Length:
28
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Q8MJM9_9PRIM
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
8
Hydrophobicity:
39.29
NuAPRpred:
-5.6
Tango:
302.17
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.4
Area of the profile Above Threshold (AGGRESCAN):
5.8
Best Energy Score (PASTA 2.0):
-5.66
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1948 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1948
Peptide:
KPYIARFEGRLFSRSDELRAVIEAHTGE
Length:
28
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Q8MJM9_9PRIM
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
10
Hydrophobicity:
42.86
NuAPRpred:
-9.87
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.6
Area of the profile Above Threshold (AGGRESCAN):
3.82
Best Energy Score (PASTA 2.0):
-2.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1949 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1949
Peptide:
VHHQKLVFFAEDVGSNKAIIGLMVGGVV
Length:
28
Classification:
Amyloid
Mutation(s):
[del]700G
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-711
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
53.57
NuAPRpred:
3.57
Tango:
893.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
19.1
Area of the profile Above Threshold (AGGRESCAN):
10.64
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1950 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Y
G
K
I
I
F
V
L
L
L
S
E
I
V
S
I
S
A
S
S
T
T
G
V
A
M
H
T
S
T
S
S
S
V
T
K
S
Y
I
S
S
Q
T
N
D
T
H
K
R
D
T
Y
A
A
T
P
R
A
H
60
61
E
V
S
E
I
S
V
R
T
V
Y
P
P
E
E
E
T
G
E
R
V
Q
L
A
H
H
F
S
E
P
E
I
T
L
I
I
F
G
V
M
A
G
V
I
G
T
I
L
L
I
S
Y
G
I
R
R
L
I
K
K
120
121
S
P
S
D
V
K
P
L
P
S
P
D
T
D
V
P
L
S
S
V
E
I
E
N
P
E
T
S
D
Q
150
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1950
Peptide:
EPEITLIIFGVMAGVIGTILLISYGIRRL
Length:
29
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02724
UniProt Name:
GLPA_HUMAN
Protein Name:
Glycophorin-A (MN sialoglycoprotein)
Position:
89-117
Literature
PMID:
15736968
Reference:
Biochemistry. 2005 Mar 8;44(9):3591-7.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
62.07
NuAPRpred:
12.73
Tango:
1706.34
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
58.0
Area of the profile Above Threshold (AGGRESCAN):
18.94
Best Energy Score (PASTA 2.0):
-15.24
Aggregate Orientation (PASTA 2.0):
Parallel
