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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 391 to 420 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0391
IEKVEH
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0392
IEMIFV
6
Amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0393
IFDFIQ
6
Amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0394
IFNYNN
6
Non-amyloid
Transcriptional activator/repressor MOT3
P54785
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0395
IFQINS
6
Amyloid
Lysozyme C
P61626
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD, AmyLoad, Waltz-DB 2.0
P-0396
IGIIKT
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0397
IGNNSI
6
Non-amyloid
Nucleoporin ASM4 (Nuclear pore protein NUP59)
Q05166
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0398
IGRTLV
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0399
IGRTLW
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
V119W
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0400
IGWGSA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0401
IHKAQN
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
20133726
Waltz-DB 2.0, AmyLoad
P-0402
IIGLMV
6
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
J Biol Chem. 2004 Dec 10;279(50):52781-8.
15459202
AmyLoad
P-0403
IIHFGS
6
Amyloid
Major prion protein (PrP)
P04156
No
Biochemistry. 2011 Apr 5;50(13):2456-63.
21323366
Waltz-DB 2.0, AmyLoad
P-0404
IINFEQ
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0405
IINFIT
6
Amyloid
No
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
14691246
Waltz-DB 2.0, AmyLoad
P-0406
IIPFEQ
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
N20P
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0407
IITVTN
6
Non-amyloid
Cell wall adhesin EAP1
G1UBC2
T131N
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0408
IKGAIK
6
Amyloid
Amyloid-beta precursor protein (APP)
P05067
N27I, I32K
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-0409
IKLANA
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0410
ILENIS
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0411
ILGSNN
6
Non-amyloid
Transcription factor RLM1
Q12224
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0412
ILQINS
6
Amyloid
Lysozyme C
P00698
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD, Waltz-DB 2.0
P-0413
ILVAGD
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0414
ILVAGS
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0415
INLYTD
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0416
INNMTN
6
Non-amyloid
Asparagine-rich protein (Protein ARP)
P32770
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0417
INNVSN
6
Non-amyloid
Nucleoporin NSP1
P14907
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0418
INPAMM
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0419
IQIMIW
6
amyloid
No
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
25133634
Waltz-DB 2.0
P-0420
IQIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623I
Switch Lab
SwitchLab
Waltz-DB 2.0
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Entry: P-0391 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0391
Peptide:
IEKVEH
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
66-71
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
33.33
NuAPRpred:
0.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-34.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-2.59
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0392 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0392
Peptide:
IEMIFV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
1.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
75.3
Area of the profile Above Threshold (AGGRESCAN):
4.8
Best Energy Score (PASTA 2.0):
-5.04
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0393 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0393
Peptide:
IFDFIQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.9
Area of the profile Above Threshold (AGGRESCAN):
2.54
Best Energy Score (PASTA 2.0):
-4.24
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0394 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
A
D
H
H
L
Q
Q
Q
Q
Q
Q
R
Q
Q
H
Q
Q
Q
Q
H
Q
Q
Q
Q
H
Q
H
Q
H
Q
Q
Q
Q
H
T
I
L
Q
N
V
S
N
T
N
N
I
G
S
D
S
L
A
S
Q
P
F
N
T
60
61
T
T
V
S
S
N
K
D
D
V
M
V
N
S
G
A
R
E
L
P
M
P
L
H
Q
Q
Q
Y
I
Y
P
Y
Y
Q
Y
T
S
N
N
S
N
N
N
N
V
T
A
G
N
N
M
S
A
S
P
I
V
H
N
N
120
121
S
N
N
S
N
N
S
N
I
S
A
S
D
Y
T
V
A
N
N
S
T
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
H
P
N
Q
F
T
A
A
A
N
M
N
S
N
A
A
A
A
A
Y
Y
S
180
181
F
P
T
A
N
M
P
I
P
Q
Q
D
Q
Q
Y
M
F
N
P
A
S
Y
I
S
H
Y
Y
S
A
V
N
S
N
N
N
G
N
N
A
A
N
N
G
S
N
N
S
S
H
S
A
P
A
P
A
P
G
P
P
H
240
241
H
H
H
H
H
S
N
T
H
N
N
L
N
N
G
G
A
V
N
T
N
N
A
P
Q
H
H
P
T
I
I
T
D
Q
F
Q
F
Q
L
Q
Q
N
P
S
P
N
L
N
L
N
I
N
P
A
Q
P
L
H
L
P
300
301
P
G
W
K
I
N
T
M
P
Q
P
R
P
T
T
A
P
N
H
P
P
A
P
V
P
S
S
N
P
V
A
S
N
L
V
P
A
P
S
S
D
H
K
Y
I
H
Q
C
Q
F
C
E
K
S
F
K
R
K
S
W
360
361
L
K
R
H
L
L
S
H
S
Q
Q
R
H
F
L
C
P
W
C
L
S
R
Q
K
R
K
D
N
L
L
Q
H
M
K
L
K
H
T
N
Y
L
L
D
E
L
K
K
N
N
I
I
F
N
Y
N
N
S
S
S
S
420
421
N
N
N
N
D
N
N
N
N
N
N
S
N
S
A
S
G
S
G
G
A
G
A
A
A
A
A
A
T
A
P
E
N
E
D
G
N
G
Y
D
T
N
I
K
T
L
I
N
D
G
V
L
N
K
D
D
V
K
R
V
480
481
L
N
N
L
I
V
S
H
N
K
490
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0394
Peptide:
IFNYNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P54785
UniProt Name:
MOT3_YEAST
Protein Name:
Transcriptional activator/repressor MOT3
Position:
411-416
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.6
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-9.7
Area of the profile Above Threshold (AGGRESCAN):
1.4
Best Energy Score (PASTA 2.0):
-3.27
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0395 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0395
Peptide:
IFQINS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
74-79
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD, AmyLoad, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.81
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.1
Area of the profile Above Threshold (AGGRESCAN):
2.08
Best Energy Score (PASTA 2.0):
-3.4
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0396 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0396
Peptide:
IGIIKT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
308-313
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
51.9
Area of the profile Above Threshold (AGGRESCAN):
3.58
Best Energy Score (PASTA 2.0):
-4.58
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0397 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
F
G
I
R
S
G
N
N
N
G
G
F
T
N
L
T
S
Q
A
P
Q
T
T
Q
M
F
Q
S
Q
S
Q
L
Q
P
Q
P
Q
P
Q
P
Q
Q
Q
Q
Q
H
L
Q
F
N
G
S
S
D
A
S
S
L
R
60
61
F
G
N
S
L
S
N
T
V
N
A
N
N
Y
S
S
N
I
G
N
N
S
I
N
N
N
N
I
K
N
G
T
N
N
I
S
Q
H
G
Q
G
N
N
P
S
W
V
N
N
P
K
K
R
F
T
P
H
T
V
I
120
121
R
R
K
T
T
K
Q
N
S
S
S
D
I
N
Q
N
D
D
S
S
S
M
N
A
T
M
R
N
F
S
K
Q
N
Q
D
S
K
H
N
E
R
N
K
S
A
A
N
N
D
I
N
S
L
L
S
N
F
N
D
I
180
181
P
P
S
V
T
L
Q
D
W
Q
R
E
D
E
F
G
S
I
P
S
L
T
T
Q
F
V
T
D
K
Y
T
A
K
K
T
N
R
S
A
Y
D
S
K
N
T
P
N
V
F
D
K
D
S
Y
V
R
I
A
N
I
240
241
E
Q
N
H
L
D
N
N
Y
N
T
A
E
T
N
N
K
V
H
E
T
S
S
K
S
S
S
L
S
A
I
I
V
F
G
Y
P
E
S
I
S
N
E
L
I
E
H
F
S
H
F
G
H
I
M
E
D
F
Q
V
300
301
L
R
L
G
R
G
I
N
P
N
T
F
R
I
F
H
N
H
D
T
G
C
D
E
N
D
S
T
V
N
K
S
I
T
L
K
G
R
N
N
E
S
N
N
K
K
Y
P
I
F
T
G
E
S
W
V
K
L
T
Y
360
361
N
S
P
S
S
A
L
R
A
L
Q
E
N
G
T
I
F
R
G
S
L
I
G
C
I
P
Y
S
K
N
A
V
E
Q
L
A
G
C
K
I
D
N
V
D
D
I
G
E
F
N
V
S
M
Y
Q
N
S
S
T
S
420
421
S
T
S
N
T
P
S
P
P
N
V
I
I
T
D
G
T
L
L
R
E
D
D
N
T
P
A
G
H
A
G
N
P
T
N
I
S
S
P
I
V
A
N
S
P
N
K
R
L
D
V
I
D
G
K
L
P
F
M
Q
480
481
N
A
G
P
N
S
N
I
P
N
L
L
R
N
L
E
S
K
M
R
Q
Q
E
A
K
Y
R
N
N
E
P
A
G
F
T
H
K
L
S
N
W
L
F
G
W
N
D
L
528
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0397
Peptide:
IGNNSI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q05166
UniProt Name:
NUP59_YEAST
Protein Name:
Nucleoporin ASM4 (Nuclear pore protein NUP59)
Position:
78-83
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.37
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-44.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.9
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0398 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0398
Peptide:
IGRTLV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.6
Area of the profile Above Threshold (AGGRESCAN):
0.74
Best Energy Score (PASTA 2.0):
-2.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0399 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0399
Peptide:
IGRTLW
Length:
6
Classification:
Non-amyloid
Mutation(s):
V119W
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
114-119
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.2
Area of the profile Above Threshold (AGGRESCAN):
0.4
Best Energy Score (PASTA 2.0):
-1.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0400 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0400
Peptide:
IGWGSA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
383-388
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.08
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.2
Area of the profile Above Threshold (AGGRESCAN):
0.45
Best Energy Score (PASTA 2.0):
-0.2
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0401 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0401
Peptide:
IHKAQN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20133726
Reference:
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3487-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-62.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.05
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0402 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0402
Peptide:
IIGLMV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
702-707
Literature
PMID:
15459202
Reference:
J Biol Chem. 2004 Dec 10;279(50):52781-8.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.04
Tango:
4.2
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
69.4
Area of the profile Above Threshold (AGGRESCAN):
4.58
Best Energy Score (PASTA 2.0):
-5.55
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0403 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0403
Peptide:
IIHFGS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
3NVF
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
138-143
Literature
PMID:
21323366
Reference:
Biochemistry. 2011 Apr 5;50(13):2456-63.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.76
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
28.8
Area of the profile Above Threshold (AGGRESCAN):
2.57
Best Energy Score (PASTA 2.0):
-4.75
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0404 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0404
Peptide:
IINFEQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
18-23
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.8
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.4
Area of the profile Above Threshold (AGGRESCAN):
1.84
Best Energy Score (PASTA 2.0):
-4.81
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0405 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0405
Peptide:
IINFIT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
14691246
Reference:
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
1.03
Tango:
1.99
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
56.2
Area of the profile Above Threshold (AGGRESCAN):
3.75
Best Energy Score (PASTA 2.0):
-6.87
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0406 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0406
Peptide:
IIPFEQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
N20P
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
18-23
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.22
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
21.7
Area of the profile Above Threshold (AGGRESCAN):
1.91
Best Energy Score (PASTA 2.0):
-0.57
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0407 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
S
Q
I
L
P
L
A
G
A
I
S
V
A
S
G
F
W
I
P
D
F
S
N
K
Q
N
S
N
S
Y
P
G
Q
Y
K
G
K
G
G
Y
Q
D
D
C
G
D
D
Y
K
K
G
Y
K
S
K
T
Y
60
61
S
K
V
K
P
I
T
S
T
D
C
T
T
P
I
Q
P
T
G
T
T
T
G
Y
T
K
D
V
V
E
S
T
S
Y
T
T
D
T
A
Y
T
T
T
V
I
T
V
T
K
C
D
G
G
S
C
S
H
T
A
V
120
121
T
T
G
V
T
I
I
T
V
T
T
N
D
V
I
T
E
Y
T
T
Y
C
P
L
T
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
180
181
E
S
T
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
240
241
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
A
S
T
E
T
A
S
S
T
P
V
E
S
T
V
I
V
P
S
T
T
V
I
T
V
S
S
C
Y
E
D
K
C
S
V
S
S
V
T
T
G
V
V
T
I
300
301
S
S
E
E
T
I
Y
T
T
Y
C
P
I
T
S
S
I
T
I
P
V
P
N
T
S
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
360
361
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
420
421
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
A
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
480
481
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
S
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
G
T
E
A
T
P
V
T
T
Q
P
540
541
V
S
V
L
S
T
S
Q
V
V
T
A
S
G
E
F
S
T
V
T
A
H
S
T
S
I
V
A
S
C
P
E
G
G
C
V
P
E
G
Q
Q
T
E
T
S
P
S
V
P
T
N
G
P
E
V
E
A
S
S
S
600
601
V
L
S
I
P
V
S
S
V
T
T
S
T
I
A
S
S
S
E
T
S
V
P
P
A
Q
V
S
T
F
E
G
S
G
S
A
L
K
K
P
Y
Y
G
L
A
V
A
A
L
V
Y
F
M
653
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0407
Peptide:
IITVTN
Length:
6
Classification:
Non-amyloid
Mutation(s):
T131N
Structure(s):
No structures
Protein Information
UniProt ID:
G1UBC2
UniProt Name:
G1UBC2_CANAL
Protein Name:
Cell wall adhesin EAP1
Position:
126-131
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.76
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.0
Area of the profile Above Threshold (AGGRESCAN):
3.16
Best Energy Score (PASTA 2.0):
-6.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0408 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0408
Peptide:
IKGAIK
Length:
6
Classification:
Amyloid
Mutation(s):
N27I, I32K
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-8.7
Area of the profile Above Threshold (AGGRESCAN):
0.45
Best Energy Score (PASTA 2.0):
-0.77
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0409 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0409
Peptide:
IKLANA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
152-157
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.2
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.1
Area of the profile Above Threshold (AGGRESCAN):
0.56
Best Energy Score (PASTA 2.0):
-0.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0410 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0410
Peptide:
ILENIS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.82
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-14.4
Area of the profile Above Threshold (AGGRESCAN):
0.54
Best Energy Score (PASTA 2.0):
-2.06
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0411 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
R
R
K
I
E
I
Q
R
I
S
D
D
R
N
R
A
V
T
F
I
K
R
K
A
G
L
F
K
K
A
H
E
L
S
V
L
C
Q
V
D
I
A
V
I
I
L
G
S
N
N
T
F
Y
E
F
S
S
V
60
61
D
T
N
D
L
I
Y
H
Y
Q
N
D
K
N
L
L
H
E
V
K
D
P
S
D
Y
G
D
F
H
K
S
A
S
V
N
I
N
Q
D
L
L
R
S
S
M
S
N
K
P
S
K
S
N
V
K
G
M
N
Q
S
120
121
E
N
D
D
D
E
N
N
D
E
D
D
D
D
H
G
N
F
E
R
N
S
N
M
H
S
N
K
K
A
S
D
K
N
I
P
S
A
H
M
K
L
L
S
P
T
A
L
I
S
K
M
D
G
S
E
Q
N
K
R
180
181
H
P
E
N
A
L
P
P
L
Q
H
L
K
R
L
K
P
D
P
L
Q
I
S
R
T
P
Q
Q
Q
Q
Q
Q
N
I
S
R
P
Y
H
S
S
M
Y
N
L
N
Q
P
S
S
S
S
S
S
P
S
T
M
D
F
240
241
P
K
L
P
S
F
Q
N
S
S
F
N
G
R
P
P
P
I
S
I
S
P
N
K
F
S
K
P
F
T
N
A
S
S
R
T
P
K
Q
E
H
K
I
N
N
S
G
S
N
N
N
D
N
S
N
Y
T
Q
S
P
300
301
S
N
S
L
E
D
S
I
Q
Q
T
V
K
A
R
R
K
L
S
A
R
P
V
L
R
V
R
I
P
N
N
N
F
S
S
N
S
A
I
P
S
E
P
S
S
A
S
S
T
S
A
N
G
N
S
M
G
S
S
Q
360
361
I
M
K
E
N
K
T
S
R
S
S
K
I
S
P
L
S
A
S
A
S
G
P
L
T
L
Q
K
G
N
N
G
R
M
V
I
K
L
P
N
A
N
A
P
N
G
S
N
N
G
N
G
S
N
N
N
N
H
P
Y
420
421
P
F
G
S
G
S
S
P
L
F
S
A
T
Q
P
Y
I
A
T
P
L
Q
P
S
N
I
P
G
G
P
F
Q
Q
N
T
S
F
L
A
Q
R
Q
T
Q
Q
Y
Q
Q
M
S
F
K
K
Q
S
Q
T
V
P
L
480
481
T
T
T
L
T
G
R
P
P
S
T
F
S
G
P
E
T
S
N
G
P
P
T
G
S
L
P
S
K
F
V
H
D
L
M
S
N
S
P
N
V
S
S
I
S
M
F
P
D
W
S
M
G
P
N
S
A
K
P
G
540
541
N
T
N
N
P
G
T
F
P
P
V
Q
T
A
V
N
N
G
N
S
S
N
I
S
S
T
N
N
T
N
N
N
N
N
N
N
N
N
N
S
S
N
N
N
S
N
N
G
N
D
N
N
S
N
N
S
N
N
S
Y
600
601
Y
S
N
N
E
D
A
P
V
N
G
A
A
I
S
E
H
T
T
D
G
D
S
N
N
Q
S
N
S
S
T
Y
D
A
A
A
T
A
Y
N
G
N
T
G
L
T
P
Y
I
N
T
A
Q
T
P
L
G
T
K
F
660
661
F
N
F
S
T
D
I
S
G
E
K
N
S
S
K
I
676
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0411
Peptide:
ILGSNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12224
UniProt Name:
RLM1_YEAST
Protein Name:
Transcription factor RLM1
Position:
47-52
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-28.4
Area of the profile Above Threshold (AGGRESCAN):
0.66
Best Energy Score (PASTA 2.0):
-0.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0412 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
S
L
L
I
L
V
L
C
F
L
P
L
A
A
L
G
K
V
F
G
R
C
E
L
A
A
A
M
K
R
H
G
L
D
N
Y
R
G
Y
S
L
G
N
W
V
C
A
A
K
F
E
S
N
F
N
T
Q
A
60
61
T
N
R
N
T
D
G
S
T
D
Y
G
I
L
Q
I
N
S
R
W
W
C
N
D
G
R
T
P
G
S
R
N
L
C
N
I
P
C
S
A
L
L
S
S
D
I
T
A
S
V
N
C
A
K
K
I
V
S
D
G
120
121
N
G
M
N
A
W
V
A
W
R
N
R
C
K
G
T
D
V
Q
A
W
I
R
G
C
R
L
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0412
Peptide:
ILQINS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00698
UniProt Name:
LYSC_CHICK
Protein Name:
Lysozyme C
Position:
73-78
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.82
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.1
Area of the profile Above Threshold (AGGRESCAN):
1.75
Best Energy Score (PASTA 2.0):
-3.27
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0413 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0413
Peptide:
ILVAGD
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.3
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.2
Area of the profile Above Threshold (AGGRESCAN):
2.62
Best Energy Score (PASTA 2.0):
-4.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0414 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0414
Peptide:
ILVAGS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.72
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
39.6
Area of the profile Above Threshold (AGGRESCAN):
2.92
Best Energy Score (PASTA 2.0):
-4.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0415 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0415
Peptide:
INLYTD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
322-327
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.1
Area of the profile Above Threshold (AGGRESCAN):
1.37
Best Energy Score (PASTA 2.0):
-3.22
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0416 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
H
Y
V
V
L
E
L
Q
V
A
H
L
P
D
T
P
K
D
Q
C
R
I
A
N
I
A
F
Q
I
V
N
A
E
T
L
V
C
H
Y
G
T
N
S
L
P
S
I
E
V
N
G
T
T
K
S
L
E
S
A
60
61
M
V
Q
L
D
K
D
I
H
D
V
I
G
N
D
D
F
V
L
V
S
L
Y
S
T
W
H
I
R
V
T
L
P
R
Q
A
R
D
D
G
F
I
L
T
S
Y
L
Q
H
P
K
V
F
D
L
W
K
E
F
D
120
121
R
W
C
V
N
H
P
E
I
L
G
Q
K
K
A
I
S
N
N
N
C
N
T
K
S
I
S
I
N
A
A
K
N
T
K
D
L
D
E
I
V
R
I
L
E
V
S
I
P
T
E
E
A
G
S
V
P
E
I
Y
180
181
S
L
L
K
R
T
T
D
I
L
I
Q
L
H
K
K
C
T
S
P
E
D
M
E
S
V
L
T
K
P
Y
D
S
H
T
D
I
R
A
F
L
Q
E
K
S
K
I
L
Y
M
N
N
L
P
P
D
T
T
Q
S
240
241
E
L
E
S
W
F
T
Q
Y
G
V
R
P
V
G
F
W
T
V
K
N
I
V
E
D
T
S
N
V
N
N
N
W
S
L
N
N
S
P
Y
V
E
D
Q
D
S
I
S
G
F
V
V
F
Q
T
H
E
E
A
T
300
301
E
V
L
A
L
N
G
R
S
I
L
S
N
L
A
N
T
K
Q
P
R
V
V
E
H
V
L
E
L
Q
P
S
S
T
G
V
L
D
K
A
Q
E
I
L
S
P
F
P
Q
S
K
N
K
P
R
P
G
D
W
N
360
361
C
P
S
C
G
F
S
N
F
Q
R
R
T
A
C
F
R
C
S
F
P
A
P
S
N
S
Q
I
H
T
A
N
S
N
N
N
V
N
S
S
R
N
N
L
N
N
R
V
N
S
G
S
S
S
N
I
S
N
T
A
420
421
A
N
H
P
Y
G
A
P
E
F
N
M
I
A
N
N
T
P
A
A
L
T
Y
N
R
A
H
F
P
A
I
T
P
L
S
R
Q
N
S
L
N
M
A
P
S
N
S
G
S
P
I
I
I
A
D
H
F
S
G
N
480
481
N
N
I
A
P
N
Y
R
Y
N
N
N
I
N
N
N
N
N
N
I
N
N
M
T
N
N
R
Y
N
I
N
N
N
I
N
G
N
G
N
G
N
G
N
N
S
N
N
N
N
N
H
N
N
N
H
N
N
N
H
H
540
541
N
G
S
I
N
S
N
S
N
T
N
N
N
N
N
N
N
N
G
N
N
S
N
N
C
N
S
N
I
G
M
G
G
C
G
S
N
M
P
F
R
A
G
D
W
K
C
S
T
C
T
Y
H
N
F
A
K
N
V
V
600
601
C
L
R
C
G
G
P
K
S
I
S
G
D
A
S
E
T
N
H
Y
I
D
S
S
T
F
G
P
A
S
R
T
P
S
N
N
N
I
S
V
N
T
N
G
G
S
N
A
G
R
T
D
G
N
D
N
K
G
R
D
660
661
I
S
L
M
E
F
M
S
P
P
L
S
M
A
T
K
S
M
K
E
G
D
G
N
G
S
S
F
N
E
F
K
S
D
K
A
N
V
N
F
S
N
V
G
D
N
S
A
F
G
N
G
F
N
S
S
I
R
W
719
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0416
Peptide:
INNMTN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32770
UniProt Name:
NRP1_YEAST
Protein Name:
Asparagine-rich protein (Protein ARP)
Position:
500-505
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.24
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-40.2
Area of the profile Above Threshold (AGGRESCAN):
0.01
Best Energy Score (PASTA 2.0):
-2.19
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0417 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
F
N
T
P
Q
Q
N
K
T
P
F
S
F
G
T
A
N
N
N
S
N
T
T
N
Q
N
S
S
T
G
A
G
A
F
G
T
G
Q
S
T
F
G
F
N
N
S
A
P
N
N
T
N
N
A
N
S
S
I
60
61
T
P
A
F
G
S
N
N
T
G
N
T
A
F
G
N
S
N
P
T
S
N
V
F
G
S
N
N
S
T
T
N
T
F
G
S
N
S
A
G
T
S
L
F
G
S
S
S
A
Q
Q
T
K
S
N
G
T
A
G
G
120
121
N
T
F
G
S
S
S
L
F
N
N
S
T
N
S
N
T
T
K
P
A
F
G
G
L
N
F
G
G
G
N
N
T
T
P
S
S
T
G
N
A
N
T
S
N
N
L
F
G
A
T
A
N
A
N
K
P
A
F
S
180
181
F
G
A
T
T
N
D
D
K
K
T
E
P
D
K
P
A
F
S
F
N
S
S
V
G
N
K
T
D
A
Q
A
P
T
T
G
F
S
F
G
S
Q
L
G
G
N
K
T
V
N
E
A
A
K
P
S
L
S
F
G
240
241
S
G
S
A
G
A
N
P
A
G
A
S
Q
P
E
P
T
T
N
E
P
A
K
P
A
L
S
F
G
T
A
T
S
D
N
K
T
T
N
T
T
P
S
F
S
F
G
A
K
S
D
E
N
K
A
G
A
T
S
K
300
301
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
360
361
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
P
D
E
N
K
A
S
A
T
S
K
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
420
421
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
S
480
481
D
E
K
K
D
S
D
S
S
K
P
A
F
S
F
G
T
K
S
N
E
K
K
D
S
G
S
S
K
P
A
F
S
F
G
A
K
P
D
E
K
K
N
D
E
V
S
K
P
A
F
S
F
G
A
K
A
N
E
K
540
541
K
E
S
D
E
S
K
S
A
F
S
F
G
S
K
P
T
G
K
E
E
G
D
G
A
K
A
A
I
S
F
G
A
K
P
E
E
Q
K
S
S
D
T
S
K
P
A
F
T
F
G
A
Q
K
D
N
E
K
K
T
600
601
E
E
S
S
T
G
K
S
T
A
D
V
K
S
S
D
S
L
K
L
N
S
K
P
V
E
L
K
P
V
S
L
D
N
K
T
L
D
D
L
V
T
K
W
T
N
Q
L
T
E
S
A
S
H
F
E
Q
Y
T
K
660
661
K
I
N
S
W
D
Q
V
L
V
K
G
G
E
Q
I
S
Q
L
Y
S
D
A
V
M
A
E
H
S
Q
N
K
I
D
Q
S
L
Q
Y
I
E
R
Q
Q
D
E
L
E
N
F
L
D
N
F
E
T
K
T
E
A
720
721
L
L
S
D
V
V
S
T
S
S
G
A
A
A
N
N
N
D
Q
K
R
Q
Q
A
Y
K
T
A
Q
T
L
D
E
N
L
N
S
L
S
S
N
L
S
S
L
I
V
E
I
N
N
V
S
N
T
F
N
K
T
T
780
781
N
I
D
I
N
N
E
D
E
N
I
Q
L
I
K
I
L
N
S
H
F
D
A
L
R
S
L
D
D
N
S
T
S
L
E
K
Q
I
N
S
I
K
K
823
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0417
Peptide:
INNVSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14907
UniProt Name:
NSP1_YEAST
Protein Name:
Nucleoporin NSP1
Position:
769-774
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-28.3
Area of the profile Above Threshold (AGGRESCAN):
0.12
Best Energy Score (PASTA 2.0):
-3.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0418 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0418
Peptide:
INPAMM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
318-323
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
-0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.4
Area of the profile Above Threshold (AGGRESCAN):
0.24
Best Energy Score (PASTA 2.0):
2.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0419 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
I
Q
I
M
I
W
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0419
Peptide:
IQIMIW
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
25133634
Reference:
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.04
Tango:
1.39
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
73.0
Area of the profile Above Threshold (AGGRESCAN):
4.68
Best Energy Score (PASTA 2.0):
-5.56
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0420 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0420
Peptide:
IQIVYK
Length:
6
Classification:
amyloid
Mutation(s):
V623I
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.71
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
58.2
Area of the profile Above Threshold (AGGRESCAN):
3.86
Best Energy Score (PASTA 2.0):
-4.95
Aggregate Orientation (PASTA 2.0):
Parallel
