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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 271 to 300 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0271
GKQAYQ
6
Non-amyloid
Alpha-galactosidase A
P06280
G328A
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0272
GKQGYQ
6
Non-amyloid
Alpha-galactosidase A
P06280
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0273
GLCYFN
6
Amyloid
ATP-binding cassette sub-family A member 3 (ABC-C transporter)
Q99758
Nat Methods. 2010 Mar;7(3):237-42., BMC Bioinformatics. 2013;14 Suppl 8:S6.
20154676
CPAD, Waltz-DB 2.0
P-0274
GLFINM
6
Amyloid
Ribose-5-phosphate isomerase
P49247
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0275
GLLLWQ
6
Non-amyloid
heparan sulfate proteoglycan core protein (HSPG)
P98160
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0276
GLSIFV
6
Amyloid
AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)
Q9Y4W6
Nat Methods. 2010 Mar;7(3):237-42., BMC Bioinformatics. 2013;14 Suppl 8:S6.
20154676
CPAD, Waltz-DB 2.0
P-0277
GMFNIQ
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0278
GMLASQ
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0279
GMLASR
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
Q343R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0280
GMMGML
6
Amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0281
GMNFGA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0282
GMNFGT
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
A315T
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0283
GMSLND
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0284
GNCFIL
6
Amyloid
Gelsolin (AGEL)
P06396
D214N
Prion. 2007 Jan-Mar;1(1):9-14.
19164912
CPAD, Waltz-DB 2.0
P-0285
GNFNNL
6
Amyloid
Protocadherin-15
Q96QU1
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0286
GNGAAV
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0287
GNGADV
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0288
GNHGGG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0289
GNNATA
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0290
GNNQQN
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0291
GNNRYQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0292
GNNSGP
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0293
GNNSYS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0294
GNQQQG
6
Non-amyloid
Waltz-DB 2.0
P-0295
GNQSGF
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
G287S
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0296
GNSALA
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0297
GNSATL
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0298
GNTCVN
6
Amyloid
Putative chaplin
B1W2X5
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad, Waltz-DB 2.0
P-0299
GNVAVA
6
amyloid
No
J Mol Biol. 2018 Oct 12;430(20):3774-3783.
29964045
Waltz-DB 2.0
P-0300
GNVCIN
6
Amyloid
Chaplin-H
Q9AD92
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad, Waltz-DB 2.0
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Entry: P-0271 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
R
N
P
E
L
H
L
G
C
A
L
A
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
A
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
W
E
R
F
M
C
N
L
D
C
Q
E
E
P
60
61
D
S
C
I
S
E
K
L
F
M
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
C
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
P
Q
R
F
P
H
G
I
R
Q
L
120
121
A
N
Y
V
H
S
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
A
D
W
G
V
D
L
L
K
F
D
G
C
Y
C
D
S
L
E
N
L
180
181
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
M
W
P
F
Q
K
P
N
Y
T
E
I
R
Q
Y
C
N
H
W
R
N
F
A
D
I
D
D
S
W
K
S
I
K
240
241
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
D
V
A
G
P
G
G
W
N
D
P
D
M
L
V
I
G
N
F
G
L
S
W
N
Q
Q
V
T
Q
M
A
L
W
A
I
M
A
A
P
L
F
M
S
N
D
L
300
301
R
H
I
S
P
Q
A
K
A
L
L
Q
D
K
D
V
I
A
I
N
Q
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
F
E
V
W
E
R
P
L
S
G
L
A
W
A
V
A
M
I
N
R
Q
E
I
G
360
361
G
P
R
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
N
P
A
C
F
I
T
Q
L
L
P
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
T
420
421
M
Q
M
S
L
K
D
L
L
429
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0271
Peptide:
GKQAYQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
G328A
Structure(s):
No structures
Protein Information
UniProt ID:
P06280
UniProt Name:
AGAL_HUMAN
Protein Name:
Alpha-galactosidase A
Position:
325-330
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-58.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.42
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0272 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
R
N
P
E
L
H
L
G
C
A
L
A
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
A
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
W
E
R
F
M
C
N
L
D
C
Q
E
E
P
60
61
D
S
C
I
S
E
K
L
F
M
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
C
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
P
Q
R
F
P
H
G
I
R
Q
L
120
121
A
N
Y
V
H
S
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
A
D
W
G
V
D
L
L
K
F
D
G
C
Y
C
D
S
L
E
N
L
180
181
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
M
W
P
F
Q
K
P
N
Y
T
E
I
R
Q
Y
C
N
H
W
R
N
F
A
D
I
D
D
S
W
K
S
I
K
240
241
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
D
V
A
G
P
G
G
W
N
D
P
D
M
L
V
I
G
N
F
G
L
S
W
N
Q
Q
V
T
Q
M
A
L
W
A
I
M
A
A
P
L
F
M
S
N
D
L
300
301
R
H
I
S
P
Q
A
K
A
L
L
Q
D
K
D
V
I
A
I
N
Q
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
F
E
V
W
E
R
P
L
S
G
L
A
W
A
V
A
M
I
N
R
Q
E
I
G
360
361
G
P
R
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
N
P
A
C
F
I
T
Q
L
L
P
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
T
420
421
M
Q
M
S
L
K
D
L
L
429
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0272
Peptide:
GKQGYQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06280
UniProt Name:
AGAL_HUMAN
Protein Name:
Alpha-galactosidase A
Position:
325-330
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-68.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.78
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0273 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0273
Peptide:
GLCYFN
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q99758
UniProt Name:
ABCA3_HUMAN
Protein Name:
ATP-binding cassette sub-family A member 3 (ABC-C transporter)
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42., BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.86
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.6
Area of the profile Above Threshold (AGGRESCAN):
2.66
Best Energy Score (PASTA 2.0):
-2.32
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0274 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
R
P
G
P
F
S
T
L
Y
G
R
V
L
A
P
L
P
G
R
A
G
G
A
A
S
G
G
G
G
N
S
W
D
L
P
G
S
H
V
R
L
P
G
R
A
Q
S
G
T
R
G
G
A
G
N
T
S
T
60
61
S
C
G
D
S
N
S
I
C
P
A
P
S
T
M
S
K
A
E
E
A
K
K
L
A
G
R
A
A
V
E
N
H
V
R
N
N
Q
V
L
G
I
G
S
G
S
T
I
V
H
A
V
Q
R
I
A
E
R
V
K
120
121
Q
E
N
L
N
L
V
C
I
P
T
S
F
Q
A
R
Q
L
I
L
Q
Y
G
L
T
L
S
D
L
D
R
H
P
E
I
D
L
A
I
D
G
A
D
E
V
D
A
D
L
N
L
I
K
G
G
G
G
C
L
T
180
181
Q
E
K
I
V
A
G
Y
A
S
R
F
I
V
I
A
D
F
R
K
D
S
K
N
L
G
D
Q
W
H
K
G
I
P
I
E
V
I
P
M
A
Y
V
P
V
S
R
A
V
S
Q
K
F
G
G
V
V
E
L
R
240
241
M
A
V
N
K
A
G
P
V
V
T
D
N
G
N
F
I
L
D
W
K
F
D
R
V
H
K
W
S
E
V
N
T
A
I
K
M
I
P
G
V
V
D
T
G
L
F
I
N
M
A
E
R
V
Y
F
G
M
Q
D
300
301
G
S
V
N
M
R
E
K
P
F
C
311
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0274
Peptide:
GLFINM
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P49247
UniProt Name:
RPIA_HUMAN
Protein Name:
Ribose-5-phosphate isomerase
Position:
285-290
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
58.2
Area of the profile Above Threshold (AGGRESCAN):
3.9
Best Energy Score (PASTA 2.0):
-3.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0275 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
W
R
A
A
G
A
L
L
L
A
L
L
L
H
G
R
L
L
A
V
T
H
G
L
R
A
Y
D
G
L
S
L
P
E
D
I
E
T
V
T
A
S
Q
M
R
W
T
H
S
Y
L
S
D
D
E
D
M
L
60
61
A
D
S
I
S
G
D
D
L
G
S
G
D
L
G
S
G
D
F
Q
M
V
Y
F
R
A
L
V
N
F
T
R
S
I
E
Y
S
P
Q
L
E
D
A
G
S
R
E
F
R
E
V
S
E
A
V
V
D
T
L
E
120
121
S
E
Y
L
K
I
P
G
D
Q
V
V
S
V
V
F
I
K
E
L
D
G
W
V
F
V
E
L
D
V
G
S
E
G
N
A
D
G
A
Q
I
Q
E
M
L
L
R
V
I
S
S
G
S
V
A
S
Y
V
T
S
180
181
P
Q
G
F
Q
F
R
R
L
G
T
V
P
Q
F
P
R
A
C
T
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A
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A
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H
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V
A
L
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Y
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C
D
R
R
P
D
C
R
D
M
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D
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C
E
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V
L
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240
241
I
S
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T
F
S
L
L
V
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T
T
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P
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L
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V
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L
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C
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A
A
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N
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R
300
301
D
Y
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D
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C
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D
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K
L
W
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C
D
G
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P
360
361
T
K
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E
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C
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C
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N
M
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M
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P
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V
V
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P
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A
S
R
420
421
G
Q
T
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T
F
T
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V
A
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T
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I
I
N
W
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L
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W
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G
R
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L
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480
481
A
M
N
A
R
G
M
V
F
G
I
P
D
G
V
L
E
L
V
P
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R
G
P
C
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D
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H
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Y
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A
A
C
L
P
C
F
C
F
G
I
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V
C
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S
T
R
R
F
R
D
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I
540
541
R
L
R
F
D
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P
D
D
F
K
G
V
N
V
T
M
P
A
Q
P
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L
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L
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F
Q
L
V
D
L
S
R
R
F
L
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F
W
A
L
P
E
600
601
Q
F
L
G
N
K
V
D
S
Y
G
G
S
L
R
Y
N
V
R
Y
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L
A
R
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M
L
E
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V
Q
R
P
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V
V
L
M
G
A
G
Y
R
L
L
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R
G
H
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T
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P
G
A
L
N
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R
660
661
Q
V
Q
F
S
E
E
H
W
V
H
E
S
G
R
P
V
Q
R
A
E
L
L
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L
Q
S
L
E
A
V
L
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T
V
Y
N
T
K
M
A
S
V
G
L
S
D
I
A
M
D
T
T
V
T
H
A
T
720
721
S
H
G
R
A
H
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V
E
E
C
R
C
P
I
G
Y
S
G
L
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C
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D
A
H
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G
P
Y
L
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T
C
S
G
C
N
C
N
G
H
A
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S
C
D
P
V
Y
G
H
C
780
781
L
N
C
Q
H
N
T
E
G
P
Q
C
N
K
C
K
A
G
F
F
G
D
A
M
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A
T
A
T
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C
R
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C
P
C
P
Y
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D
A
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R
R
F
S
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C
F
L
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D
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Q
A
T
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D
840
841
A
C
A
P
G
Y
T
G
R
R
C
E
S
C
A
P
G
Y
E
G
N
P
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G
G
K
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V
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V
R
C
D
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R
G
S
M
G
T
S
G
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A
C
R
C
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N
N
V
V
G
900
901
R
L
C
N
E
C
A
D
G
S
F
H
L
S
T
R
N
P
D
G
C
L
K
C
F
C
M
G
V
S
R
H
C
T
S
S
S
W
S
R
A
Q
L
H
G
A
S
E
E
P
G
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S
L
T
N
A
A
S
960
961
T
H
T
T
N
E
G
I
F
S
P
T
P
G
E
L
G
F
S
S
F
H
R
L
L
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P
Y
F
W
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L
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F
L
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D
K
V
T
S
Y
G
G
E
L
R
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V
T
Q
R
S
Q
P
G
1020
1021
S
T
P
L
H
G
Q
P
L
V
V
L
Q
G
N
N
I
I
L
E
H
H
V
A
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P
S
P
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P
S
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F
I
V
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R
E
Q
A
W
Q
R
P
D
G
Q
P
A
T
R
E
H
L
L
M
A
1080
1081
L
A
G
I
D
T
L
L
I
R
A
S
Y
A
Q
Q
P
A
E
S
R
V
S
G
I
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M
D
V
A
V
P
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G
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D
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A
L
E
V
E
Q
C
S
C
P
P
G
Y
R
G
P
S
C
Q
D
C
1140
1141
D
T
G
Y
T
R
T
P
S
G
L
Y
L
G
T
C
E
R
C
S
C
H
G
H
S
E
A
C
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P
E
T
G
A
C
Q
G
C
Q
H
H
T
E
G
P
R
C
E
Q
C
Q
P
G
Y
Y
G
D
A
Q
R
1200
1201
G
T
P
Q
D
C
Q
L
C
P
C
Y
G
D
P
A
A
G
Q
A
A
H
T
C
F
L
D
T
D
G
H
P
T
C
D
A
C
S
P
G
H
S
G
R
H
C
E
R
C
A
P
G
Y
Y
G
N
P
S
Q
G
1260
1261
Q
P
C
Q
R
D
S
Q
V
P
G
P
I
G
C
N
C
D
P
Q
G
S
V
S
S
Q
C
D
A
A
G
Q
C
Q
C
K
A
Q
V
E
G
L
T
C
S
H
C
R
P
H
H
F
H
L
S
A
S
N
P
D
1320
1321
G
C
L
P
C
F
C
M
G
I
T
Q
Q
C
A
S
S
A
Y
T
R
H
L
I
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T
H
F
A
P
G
D
F
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G
F
A
L
V
N
P
Q
R
N
S
R
L
T
G
E
F
T
V
E
P
V
P
E
G
A
1380
1381
Q
L
S
F
G
N
F
A
Q
L
G
H
E
S
F
Y
W
Q
L
P
E
T
Y
Q
G
D
K
V
A
A
Y
G
G
K
L
R
Y
T
L
S
Y
T
A
G
P
Q
G
S
P
L
S
D
P
D
V
Q
I
T
G
N
1440
1441
N
I
M
L
V
A
S
Q
P
A
L
Q
G
P
E
R
R
S
Y
E
I
M
F
R
E
E
F
W
R
R
P
D
G
Q
P
A
T
R
E
H
L
L
M
A
L
A
D
L
D
E
L
L
I
R
A
T
F
S
S
V
1500
1501
P
L
A
A
S
I
S
A
V
S
L
E
V
A
Q
P
G
P
S
N
R
P
R
A
L
E
V
E
E
C
R
C
P
P
G
Y
I
G
L
S
C
Q
D
C
A
P
G
Y
T
R
T
G
S
G
L
Y
L
G
H
C
1560
1561
E
L
C
E
C
N
G
H
S
D
L
C
H
P
E
T
G
A
C
S
Q
C
Q
H
N
A
A
G
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F
C
E
L
C
A
P
G
Y
Y
G
D
A
T
A
G
T
P
E
D
C
Q
P
C
A
C
P
L
T
N
P
1620
1621
E
N
M
F
S
R
T
C
E
S
L
G
A
G
G
Y
R
C
T
A
C
E
P
G
Y
T
G
Q
Y
C
E
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C
G
P
G
Y
V
G
N
P
S
V
Q
G
G
Q
C
L
P
E
T
N
Q
A
P
L
V
V
E
1680
1681
V
H
P
A
R
S
I
V
P
Q
G
G
S
H
S
L
R
C
Q
V
S
G
S
P
P
H
Y
F
Y
W
S
R
E
D
G
R
P
V
P
S
G
T
Q
Q
R
H
Q
G
S
E
L
H
F
P
S
V
Q
P
S
D
1740
1741
A
G
V
Y
I
C
T
C
R
N
L
H
Q
S
N
T
S
R
A
E
L
L
V
T
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A
P
S
K
P
I
T
V
T
V
E
E
Q
R
S
Q
S
V
R
P
G
A
D
V
T
F
I
C
T
A
K
S
K
S
P
1800
1801
A
Y
T
L
V
W
T
R
L
H
N
G
K
L
P
T
R
A
M
D
F
N
G
I
L
T
I
R
N
V
Q
L
S
D
A
G
T
Y
V
C
T
G
S
N
M
F
A
M
D
Q
G
T
A
T
L
H
V
Q
A
S
1860
1861
G
T
L
S
A
P
V
V
S
I
H
P
P
Q
L
T
V
Q
P
G
Q
L
A
E
F
R
C
S
A
T
G
S
P
T
P
T
L
E
W
T
G
G
P
G
G
Q
L
P
A
K
A
Q
I
H
G
G
I
L
R
L
1920
1921
P
A
V
E
P
T
D
Q
A
Q
Y
L
C
R
A
H
S
S
A
G
Q
Q
V
A
R
A
V
L
H
V
H
G
G
G
G
P
R
V
Q
V
S
P
E
R
T
Q
V
H
A
G
R
T
V
R
L
Y
C
R
A
A
1980
1981
G
V
P
S
A
T
I
T
W
R
K
E
G
G
S
L
P
P
Q
A
R
S
E
R
T
D
I
A
T
L
L
I
P
A
I
T
T
A
D
A
G
F
Y
L
C
V
A
T
S
P
A
G
T
A
Q
A
R
I
Q
V
2040
2041
V
V
L
S
A
S
D
A
S
P
P
P
V
K
I
E
S
S
S
P
S
V
T
E
G
Q
T
L
D
L
N
C
V
V
A
G
S
A
H
A
Q
V
T
W
Y
R
R
G
G
S
L
P
P
H
T
Q
V
H
G
S
2100
2101
R
L
R
L
P
Q
V
S
P
A
D
S
G
E
Y
V
C
R
V
E
N
G
S
G
P
K
E
A
S
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T
V
S
V
L
H
G
T
H
S
G
P
S
Y
T
P
V
P
G
S
T
R
P
I
R
I
E
P
S
S
2160
2161
S
H
V
A
E
G
Q
T
L
D
L
N
C
V
V
P
G
Q
A
H
A
Q
V
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W
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G
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L
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L
L
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L
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V
C
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V
2220
2221
V
G
T
S
G
P
L
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A
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A
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L
D
L
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V
A
G
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A
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A
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2280
2281
R
G
G
S
L
P
A
R
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V
R
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R
L
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I
F
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A
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A
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A
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V
C
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A
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M
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A
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T
V
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T
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G
A
N
L
A
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P
A
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2340
2341
Q
P
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R
I
E
P
S
S
S
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V
A
E
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Q
T
L
D
L
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C
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V
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H
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G
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L
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A
2400
2401
D
S
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L
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V
2460
2461
A
G
Q
A
H
A
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V
T
W
H
K
R
G
G
S
L
P
A
R
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H
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L
R
L
L
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C
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V
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2520
2521
Q
Q
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2580
2581
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G
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V
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S
G
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T
2640
2641
V
V
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Q
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D
L
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C
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V
A
R
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P
Q
A
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I
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W
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G
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L
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A
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N
2700
2701
N
I
D
A
L
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A
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I
V
I
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V
S
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S
A
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S
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V
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A
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A
Q
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2760
2761
H
K
R
G
G
S
L
P
S
H
H
Q
T
R
G
S
R
L
R
L
H
H
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A
D
S
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E
Y
V
C
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V
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S
G
P
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L
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A
V
H
V
2820
2821
P
A
P
G
G
A
P
P
I
R
I
E
P
S
S
S
R
V
A
E
G
Q
T
L
D
L
K
C
V
V
P
G
Q
A
H
A
Q
V
T
W
H
K
R
G
G
N
L
P
A
R
H
Q
V
H
G
P
L
L
R
L
2880
2881
N
Q
V
S
P
A
D
S
G
E
Y
S
C
Q
V
T
G
S
S
G
T
L
E
A
S
V
L
V
T
I
E
P
S
S
P
G
P
I
P
A
P
G
L
A
Q
P
I
Y
I
E
A
S
S
S
H
V
T
E
G
Q
2940
2941
T
L
D
L
N
C
V
V
P
G
Q
A
H
A
Q
V
T
W
Y
K
R
G
G
S
L
P
A
R
H
Q
T
H
G
S
Q
L
R
L
H
L
V
S
P
A
D
S
G
E
Y
V
C
R
A
A
S
G
P
G
P
E
3000
3001
Q
E
A
S
F
T
V
T
V
P
P
S
E
G
S
S
Y
R
L
R
S
P
V
I
S
I
D
P
P
S
S
T
V
Q
Q
G
Q
D
A
S
F
K
C
L
I
H
D
G
A
A
P
I
S
L
E
W
K
T
R
N
3060
3061
Q
E
L
E
D
N
V
H
I
S
P
N
G
S
I
I
T
I
V
G
T
R
P
S
N
H
G
T
Y
R
C
V
A
S
N
A
Y
G
V
A
Q
S
V
V
N
L
S
V
H
G
P
P
T
V
S
V
L
P
E
G
3120
3121
P
V
W
V
K
V
G
K
A
V
T
L
E
C
V
S
A
G
E
P
R
S
S
A
R
W
T
R
I
S
S
T
P
A
K
L
E
Q
R
T
Y
G
L
M
D
S
H
A
V
L
Q
I
S
S
A
K
P
S
D
A
3180
3181
G
T
Y
V
C
L
A
Q
N
A
L
G
T
A
Q
K
Q
V
E
V
I
V
D
T
G
A
M
A
P
G
A
P
Q
V
Q
A
E
E
A
E
L
T
V
E
A
G
H
T
A
T
L
R
C
S
A
T
G
S
P
A
3240
3241
P
T
I
H
W
S
K
L
R
S
P
L
P
W
Q
H
R
L
E
G
D
T
L
I
I
P
R
V
A
Q
Q
D
S
G
Q
Y
I
C
N
A
T
S
P
A
G
H
A
E
A
T
I
I
L
H
V
E
S
P
P
Y
3300
3301
A
T
T
V
P
E
H
A
S
V
Q
A
G
E
T
V
Q
L
Q
C
L
A
H
G
T
P
P
L
T
F
Q
W
S
R
V
G
S
S
L
P
G
R
A
T
A
R
N
E
L
L
H
F
E
R
A
A
P
E
D
S
3360
3361
G
R
Y
R
C
R
V
T
N
K
V
G
S
A
E
A
F
A
Q
L
L
V
Q
G
P
P
G
S
L
P
A
T
S
I
P
A
G
S
T
P
T
V
Q
V
T
P
Q
L
E
T
K
S
I
G
A
S
V
E
F
H
3420
3421
C
A
V
P
S
D
R
G
T
Q
L
R
W
F
K
E
G
G
Q
L
P
P
G
H
S
V
Q
D
G
V
L
R
I
Q
N
L
D
Q
S
C
Q
G
T
Y
I
C
Q
A
H
G
P
W
G
K
A
Q
A
S
A
Q
3480
3481
L
V
I
Q
A
L
P
S
V
L
I
N
I
R
T
S
V
Q
T
V
V
V
G
H
A
V
E
F
E
C
L
A
L
G
D
P
K
P
Q
V
T
W
S
K
V
G
G
H
L
R
P
G
I
V
Q
S
G
G
V
V
3540
3541
R
I
A
H
V
E
L
A
D
A
G
Q
Y
R
C
T
A
T
N
A
A
G
T
T
Q
S
H
V
L
L
L
V
Q
A
L
P
Q
I
S
M
P
Q
E
V
R
V
P
A
G
S
A
A
V
F
P
C
I
A
S
G
3600
3601
Y
P
T
P
D
I
S
W
S
K
L
D
G
S
L
P
P
D
S
R
L
E
N
N
M
L
M
L
P
S
V
R
P
Q
D
A
G
T
Y
V
C
T
A
T
N
R
Q
G
K
V
K
A
F
A
H
L
Q
V
P
E
3660
3661
R
V
V
P
Y
F
T
Q
T
P
Y
S
F
L
P
L
P
T
I
K
D
A
Y
R
K
F
E
I
K
I
T
F
R
P
D
S
A
D
G
M
L
L
Y
N
G
Q
K
R
V
P
G
S
P
T
N
L
A
N
R
Q
3720
3721
P
D
F
I
S
F
G
L
V
G
G
R
P
E
F
R
F
D
A
G
S
G
M
A
T
I
R
H
P
T
P
L
A
L
G
H
F
H
T
V
T
L
L
R
S
L
T
Q
G
S
L
I
V
G
D
L
A
P
V
N
3780
3781
G
T
S
Q
G
K
F
Q
G
L
D
L
N
E
E
L
Y
L
G
G
Y
P
D
Y
G
A
I
P
K
A
G
L
S
S
G
F
I
G
C
V
R
E
L
R
I
Q
G
E
E
I
V
F
H
D
L
N
L
T
A
H
3840
3841
G
I
S
H
C
P
T
C
R
D
R
P
C
Q
N
G
G
Q
C
H
D
S
E
S
S
S
Y
V
C
V
C
P
A
G
F
T
G
S
R
C
E
H
S
Q
A
L
H
C
H
P
E
A
C
G
P
D
A
T
C
V
3900
3901
N
R
P
D
G
R
G
Y
T
C
R
C
H
L
G
R
S
G
L
R
C
E
E
G
V
T
V
T
T
P
S
L
S
G
A
G
S
Y
L
A
L
P
A
L
T
N
T
H
H
E
L
R
L
D
V
E
F
K
P
L
3960
3961
A
P
D
G
V
L
L
F
S
G
G
K
S
G
P
V
E
D
F
V
S
L
A
M
V
G
G
H
L
E
F
R
Y
E
L
G
S
G
L
A
V
L
R
S
A
E
P
L
A
L
G
R
W
H
R
V
S
A
E
R
4020
4021
L
N
K
D
G
S
L
R
V
N
G
G
R
P
V
L
R
S
S
P
G
K
S
Q
G
L
N
L
H
T
L
L
Y
L
G
G
V
E
P
S
V
P
L
S
P
A
T
N
M
S
A
H
F
R
G
C
V
G
E
V
4080
4081
S
V
N
G
K
R
L
D
L
T
Y
S
F
L
G
S
Q
G
I
G
Q
C
Y
D
S
S
P
C
E
R
Q
P
C
Q
H
G
A
T
C
M
P
A
G
E
Y
E
F
Q
C
L
C
R
D
G
F
K
G
D
L
C
4140
4141
E
H
E
E
N
P
C
Q
L
R
E
P
C
L
H
G
G
T
C
Q
G
T
R
C
L
C
L
P
G
F
S
G
P
R
C
Q
Q
G
S
G
H
G
I
A
E
S
D
W
H
L
E
G
S
G
G
N
D
A
P
G
4200
4201
Q
Y
G
A
Y
F
H
D
D
G
F
L
A
F
P
G
H
V
F
S
R
S
L
P
E
V
P
E
T
I
E
L
E
V
R
T
S
T
A
S
G
L
L
L
W
Q
G
V
E
V
G
E
A
G
Q
G
K
D
F
I
4260
4261
S
L
G
L
Q
D
G
H
L
V
F
R
Y
Q
L
G
S
G
E
A
R
L
V
S
E
D
P
I
N
D
G
E
W
H
R
V
T
A
L
R
E
G
R
R
G
S
I
Q
V
D
G
E
E
L
V
S
G
R
S
P
4320
4321
G
P
N
V
A
V
N
A
K
G
S
V
Y
I
G
G
A
P
D
V
A
T
L
T
G
G
R
F
S
S
G
I
T
G
C
V
K
N
L
V
L
H
S
A
R
P
G
A
P
P
P
Q
P
L
D
L
Q
H
R
A
4380
4381
Q
A
G
A
N
T
R
P
C
P
S
4391
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0275
Peptide:
GLLLWQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P98160
UniProt Name:
PGBM_HUMAN
Protein Name:
heparan sulfate proteoglycan core protein (HSPG)
Position:
4241-4246
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.88
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
51.7
Area of the profile Above Threshold (AGGRESCAN):
3.43
Best Energy Score (PASTA 2.0):
-3.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0276 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0276
Peptide:
GLSIFV
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q9Y4W6
UniProt Name:
AFG32_HUMAN
Protein Name:
AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein)
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42., BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.93
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
64.9
Area of the profile Above Threshold (AGGRESCAN):
4.1
Best Energy Score (PASTA 2.0):
-4.96
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0277 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0277
Peptide:
GMFNIQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.7
Area of the profile Above Threshold (AGGRESCAN):
0.98
Best Energy Score (PASTA 2.0):
-3.02
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0278 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0278
Peptide:
GMLASQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
338-343
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.6
Area of the profile Above Threshold (AGGRESCAN):
0.57
Best Energy Score (PASTA 2.0):
0.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0279 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0279
Peptide:
GMLASR
Length:
6
Classification:
Non-amyloid
Mutation(s):
Q343R
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
338-343
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.7
Area of the profile Above Threshold (AGGRESCAN):
0.57
Best Energy Score (PASTA 2.0):
0.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0280 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0280
Peptide:
GMMGML
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
335-340
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
22.2
Area of the profile Above Threshold (AGGRESCAN):
1.76
Best Energy Score (PASTA 2.0):
-0.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0281 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0281
Peptide:
GMNFGA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
310-315
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-9.7
Area of the profile Above Threshold (AGGRESCAN):
0.26
Best Energy Score (PASTA 2.0):
0.29
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0282 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0282
Peptide:
GMNFGT
Length:
6
Classification:
Non-amyloid
Mutation(s):
A315T
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
310-315
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.0
Area of the profile Above Threshold (AGGRESCAN):
0.23
Best Energy Score (PASTA 2.0):
0.21
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0283 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0283
Peptide:
GMSLND
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
123-128
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-25.3
Area of the profile Above Threshold (AGGRESCAN):
0.05
Best Energy Score (PASTA 2.0):
-0.25
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0284 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0284
Peptide:
GNCFIL
Length:
6
Classification:
Amyloid
Mutation(s):
D214N
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
213-218
Literature
PMID:
19164912
Reference:
Prion. 2007 Jan-Mar;1(1):9-14.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
1.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
44.5
Area of the profile Above Threshold (AGGRESCAN):
3.19
Best Energy Score (PASTA 2.0):
-3.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0285 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
F
R
Q
F
Y
L
W
T
C
L
A
S
G
I
I
L
G
S
L
F
E
I
C
L
G
Q
Y
D
D
D
C
K
L
A
R
G
G
P
P
A
T
I
V
A
I
D
E
E
S
R
N
G
T
I
L
V
D
N
M
60
61
L
I
K
G
T
A
G
G
P
D
P
T
I
E
L
S
L
K
D
N
V
D
Y
W
V
L
M
D
P
V
K
Q
M
L
F
L
N
S
T
G
R
V
L
D
R
D
P
P
M
N
I
H
S
I
V
V
Q
V
Q
C
120
121
I
N
K
K
V
G
T
I
I
Y
H
E
V
R
I
V
V
R
D
R
N
D
N
S
P
T
F
K
H
E
S
Y
Y
A
T
V
N
E
L
T
P
V
G
T
T
I
F
T
G
F
S
G
D
N
G
A
T
D
I
D
180
181
D
G
P
N
G
Q
I
E
Y
V
I
Q
Y
N
P
D
D
P
T
S
N
D
T
F
E
I
P
L
M
L
T
G
N
I
V
L
R
K
R
L
N
Y
E
D
K
T
R
Y
F
V
I
I
Q
A
N
D
R
A
Q
N
240
241
L
N
E
R
R
T
T
T
T
T
L
T
V
D
V
L
D
G
D
D
L
G
P
M
F
L
P
C
V
L
V
P
N
T
R
D
C
R
P
L
T
Y
Q
A
A
I
P
E
L
R
T
P
E
E
L
N
P
I
I
V
300
301
T
P
P
I
Q
A
I
D
Q
D
R
N
I
Q
P
P
S
D
R
P
G
I
L
Y
S
I
L
V
G
T
P
E
D
Y
P
R
F
F
H
M
H
P
R
T
A
E
L
S
L
L
E
P
V
N
R
D
F
H
Q
K
360
361
F
D
L
V
I
K
A
E
Q
D
N
G
H
P
L
P
A
F
A
G
L
H
I
E
I
L
D
E
N
N
Q
S
P
Y
F
T
M
P
S
Y
Q
G
Y
I
L
E
S
A
P
V
G
A
T
I
S
D
S
L
N
L
420
421
T
S
P
L
R
I
V
A
L
D
K
D
I
E
D
T
K
D
P
E
L
H
L
F
L
N
D
Y
T
S
V
F
T
V
T
Q
T
G
I
T
R
Y
L
T
L
L
Q
P
V
D
R
E
E
Q
Q
T
Y
T
F
S
480
481
I
T
A
F
D
G
V
Q
E
S
E
P
V
I
V
N
I
Q
V
M
D
A
N
D
N
T
P
T
F
P
E
I
S
Y
D
V
Y
V
Y
T
D
M
R
P
G
D
S
V
I
Q
L
T
A
V
D
A
D
E
G
S
540
541
N
G
E
I
T
Y
E
I
L
V
G
A
Q
G
D
F
I
I
N
K
T
T
G
L
I
T
I
A
P
G
V
E
M
I
V
G
R
T
Y
A
L
T
V
Q
A
A
D
N
A
P
P
A
E
R
R
N
S
I
C
T
600
601
V
Y
I
E
V
L
P
P
N
N
Q
S
P
P
R
F
P
Q
L
M
Y
S
L
E
I
S
E
A
M
R
V
G
A
V
L
L
N
L
Q
A
T
D
R
E
G
D
S
I
T
Y
A
I
E
N
G
D
P
Q
R
V
660
661
F
N
L
S
E
T
T
G
I
L
T
L
G
K
A
L
D
R
E
S
T
D
R
Y
I
L
I
I
T
A
S
D
G
R
P
D
G
T
S
T
A
T
V
N
I
V
V
T
D
V
N
D
N
A
P
V
F
D
P
Y
720
721
L
P
R
N
L
S
V
V
E
E
E
A
N
A
F
V
G
Q
V
K
A
T
D
P
D
A
G
I
N
G
Q
V
H
Y
S
L
G
N
F
N
N
L
F
R
I
T
S
N
G
S
I
Y
T
A
V
K
L
N
R
E
780
781
V
R
D
Y
Y
E
L
V
V
V
A
T
D
G
A
V
H
P
R
H
S
T
L
T
L
A
I
K
V
L
D
I
D
D
N
S
P
V
F
T
N
S
T
Y
T
V
L
V
E
E
N
L
P
A
G
T
T
I
L
Q
840
841
I
E
A
K
D
V
D
L
G
A
N
V
S
Y
R
I
R
S
P
E
V
K
H
F
F
A
L
H
P
F
T
G
E
L
S
L
L
R
S
L
D
Y
E
A
F
P
D
Q
E
A
S
I
T
F
L
V
E
A
F
D
900
901
I
Y
G
T
M
P
P
G
I
A
T
V
T
V
I
V
K
D
M
N
D
Y
P
P
V
F
S
K
R
I
Y
K
G
M
V
A
P
D
A
V
K
G
T
P
I
T
T
V
Y
A
E
D
A
D
P
P
G
L
P
A
960
961
S
R
V
R
Y
R
V
D
D
V
Q
F
P
Y
P
A
S
I
F
E
V
E
E
D
S
G
R
V
I
T
R
V
N
L
N
E
E
P
T
T
I
F
K
L
V
V
V
A
F
D
D
G
E
P
V
M
S
S
S
A
1020
1021
T
V
K
I
L
V
L
H
P
G
E
I
P
R
F
T
Q
E
E
Y
R
P
P
P
V
S
E
L
A
T
K
G
T
M
V
G
V
I
S
A
A
A
I
N
Q
S
I
V
Y
S
I
V
S
G
N
E
E
D
T
F
1080
1081
G
I
N
N
I
T
G
V
I
Y
V
N
G
P
L
D
Y
E
T
R
T
S
Y
V
L
R
V
Q
A
D
S
L
E
V
V
L
A
N
L
R
V
P
S
K
S
N
T
A
K
V
Y
I
E
I
Q
D
E
N
N
H
1140
1141
P
P
V
F
Q
K
K
F
Y
I
G
G
V
S
E
D
A
R
M
F
T
S
V
L
R
V
K
A
T
D
K
D
T
G
N
Y
S
V
M
A
Y
R
L
I
I
P
P
I
K
E
G
K
E
G
F
V
V
E
T
Y
1200
1201
T
G
L
I
K
T
A
M
L
F
H
N
M
R
R
S
Y
F
K
F
Q
V
I
A
T
D
D
Y
G
K
G
L
S
G
K
A
D
V
L
V
S
V
V
N
Q
L
D
M
Q
V
I
V
S
N
V
P
P
T
L
V
1260
1261
E
K
K
I
E
D
L
T
E
I
L
D
R
Y
V
Q
E
Q
I
P
G
A
K
V
V
V
E
S
I
G
A
R
R
H
G
D
A
F
S
L
E
D
Y
T
K
C
D
L
T
V
Y
A
I
D
P
Q
T
N
R
A
1320
1321
I
D
R
N
E
L
F
K
F
L
D
G
K
L
L
D
I
N
K
D
F
Q
P
Y
Y
G
E
G
G
R
I
L
E
I
R
T
P
E
A
V
T
S
I
K
K
R
G
E
S
L
G
Y
T
E
G
A
L
L
A
L
1380
1381
A
F
I
I
I
L
C
C
I
P
A
I
L
V
V
L
V
S
Y
R
Q
F
K
V
R
Q
A
E
C
T
K
T
A
R
I
Q
A
A
L
P
A
A
K
P
A
V
P
A
P
A
P
V
A
A
P
P
P
P
P
P
1440
1441
P
P
P
G
A
H
L
Y
E
E
L
G
D
S
S
I
L
F
L
L
Y
H
F
Q
Q
S
R
G
N
N
S
V
S
E
D
R
K
H
Q
Q
V
V
M
P
F
S
S
N
T
I
E
A
H
K
S
A
H
V
D
G
1500
1501
S
L
K
S
N
K
L
K
S
A
R
K
F
T
F
L
S
D
E
D
D
L
S
A
H
N
P
L
Y
K
E
N
I
S
Q
V
S
T
N
S
D
I
S
Q
R
T
D
F
V
D
P
F
S
P
K
I
Q
A
K
S
1560
1561
K
S
L
R
G
P
R
E
K
I
Q
R
L
W
S
Q
S
V
S
L
P
R
R
L
M
R
K
V
P
N
R
P
E
I
I
D
L
Q
Q
W
Q
G
T
R
Q
K
A
E
N
E
N
T
G
I
C
T
N
K
R
G
1620
1621
S
S
N
P
L
L
T
T
E
E
A
N
L
T
E
K
E
E
I
R
Q
G
E
T
L
M
I
E
G
T
E
Q
L
K
S
L
S
S
D
S
S
F
C
F
P
R
P
H
F
S
F
S
T
L
P
T
V
S
R
T
1680
1681
V
E
L
K
S
E
P
N
V
I
S
S
P
A
E
C
S
L
E
L
S
P
S
R
P
C
V
L
H
S
S
L
S
R
R
E
T
P
I
C
M
L
P
I
E
T
E
R
N
I
F
E
N
F
A
H
P
P
N
I
1740
1741
S
P
S
A
C
P
L
P
P
P
P
P
I
S
P
P
S
P
P
P
A
P
A
P
L
A
P
P
P
D
I
S
P
F
S
L
F
C
P
P
P
S
P
P
S
I
P
L
P
L
P
P
P
T
F
F
P
L
S
V
1800
1801
S
T
S
G
P
P
T
P
P
L
L
P
P
F
P
T
P
L
P
P
P
P
P
S
I
P
C
P
P
P
P
S
A
S
F
L
S
T
E
C
V
C
I
T
G
V
K
C
T
T
N
L
M
P
A
E
K
I
K
S
1860
1861
S
M
T
Q
L
S
T
T
T
V
C
K
T
D
P
Q
R
E
P
K
G
I
L
R
H
V
K
N
L
A
E
L
E
K
S
V
A
N
M
Y
S
Q
I
E
K
N
Y
L
R
T
N
V
S
E
L
Q
T
M
C
P
1920
1921
S
E
V
T
N
M
E
I
T
S
E
Q
N
K
G
S
L
N
N
I
V
E
G
T
E
K
Q
S
H
S
Q
S
T
S
L
1955
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0285
Peptide:
GNFNNL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q96QU1
UniProt Name:
PCD15_HUMAN
Protein Name:
Protocadherin-15
Position:
757-762
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-35.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.6
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0286 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0286
Peptide:
GNGAAV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
121-126
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.3
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0287 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0287
Peptide:
GNGADV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
76-81
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0288 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0288
Peptide:
GNHGGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
30-35
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-84.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.73
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0289 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0289
Peptide:
GNNATA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
143-148
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-70.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0290 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0290
Peptide:
GNNQQN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
7-12
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-120.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.8
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0291 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0291
Peptide:
GNNRYQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
25-30
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-88.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.18
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0292 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0292
Peptide:
GNNSGP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
36-41
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-83.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.04
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0293 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0293
Peptide:
GNNSYS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
370-375
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0294 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0294
Peptide:
GNQQQG
Length:
6
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-111.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.45
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0295 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0295
Peptide:
GNQSGF
Length:
6
Classification:
Non-amyloid
Mutation(s):
G287S
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
284-289
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.85
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0296 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0296
Peptide:
GNSALA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
53-58
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.41
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-29.3
Area of the profile Above Threshold (AGGRESCAN):
0.01
Best Energy Score (PASTA 2.0):
0.43
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0297 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0297
Peptide:
GNSATL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
98-103
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-35.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0298 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
I
K
K
V
V
A
V
A
A
A
T
G
G
L
V
L
A
G
A
G
M
A
S
A
D
A
G
A
Q
G
A
A
I
G
S
P
G
V
L
S
G
N
V
V
Q
V
P
V
H
V
P
I
N
V
C
G
N
T
V
60
61
S
V
I
G
L
L
N
P
A
F
G
N
T
C
V
N
A
77
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0298
Peptide:
GNTCVN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B1W2X5
UniProt Name:
B1W2X5_STRGG
Protein Name:
Putative chaplin
Position:
71-76
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.31
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.6
Area of the profile Above Threshold (AGGRESCAN):
0.06
Best Energy Score (PASTA 2.0):
-2.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0299 Classification: amyloid
CSV
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Sequence
1
G
N
V
A
V
A
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0299
Peptide:
GNVAVA
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
29964045
Reference:
J Mol Biol. 2018 Oct 12;430(20):3774-3783.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
11.3
Area of the profile Above Threshold (AGGRESCAN):
1.52
Best Energy Score (PASTA 2.0):
-3.49
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0300 Classification: Amyloid
CSV
JSON
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Sequence
1
M
L
K
K
V
V
A
A
A
A
A
T
G
G
L
V
L
A
G
A
G
M
A
V
A
D
S
G
A
Q
G
A
A
V
H
S
P
G
V
L
S
G
N
V
V
Q
V
P
V
H
V
P
V
N
V
C
G
N
T
I
60
61
S
V
I
G
L
L
N
P
A
F
G
N
V
C
I
N
K
77
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0300
Peptide:
GNVCIN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q9AD92
UniProt Name:
CHPH_STRCO
Protein Name:
Chaplin-H
Position:
71-76
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.9
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.5
Area of the profile Above Threshold (AGGRESCAN):
1.45
Best Energy Score (PASTA 2.0):
-4.03
Aggregate Orientation (PASTA 2.0):
Parallel
