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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 301 to 330 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0301
GNYKNF
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0302
GQGSDD
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0303
GQIVYK
6
non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623G
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0304
GQNNTQ
6
Non-amyloid
Transcription factor PDR1 (Pleiotropic drug resistance protein 1)
P12383
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0305
GQQNQY
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0306
GQQQSY
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0307
GQQSYS
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0308
GQSSYS
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0309
GRGNYK
6
Non-amyloid
Waltz-DB 2.0
P-0310
GRIGIA
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
V149R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0311
GSASNA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0312
GSGFNG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0313
GSGSGF
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0314
GSHLVE
6
Non-amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0315
GSIAAT
6
Amyloid
Alpha-synuclein
P37840
[del]89A
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD, Waltz-DB 2.0
P-0316
GSNNTF
6
Non-amyloid
Transcription factor RLM1
Q12224
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0317
GSNSGA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0318
GTFFIN
6
Amyloid
Beta-hexosaminidase subunit alpha
P06865
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0319
GTFFIT
6
Amyloid
Bardet-Biedl syndrome 5 protein
Q8N3I7
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0320
GTFFQE
6
Non-amyloid
GDH/6PGL endoplasmic bifunctional protein
O95479
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0321
GTFNII
6
Amyloid
Polycystin-1 (PC1)
P98161
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0322
GTFSIN
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
A315T
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0323
GTLFWG
6
amyloid
No
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
25133634
Waltz-DB 2.0
P-0324
GTLVFM
6
Amyloid
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-0325
GTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0326
GTVLFM
6
Amyloid
Plasminogen activator inhibitor 1 (PAI)
P05121
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0327
GTVWWG
6
amyloid
No
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
25133634
Waltz-DB 2.0
P-0328
GVATVA
6
Amyloid
Alpha-synuclein
P37840
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD, Waltz-DB 2.0
P-0329
GVFNNQ
6
Non-amyloid
Brain cyclic nucleotide-gated channel 1 (BCNG-1)
O60741
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0330
GVIGIA
6
Amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0301 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0301
Peptide:
GNYKNF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
99-104
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.34
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.03
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0302 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0302
Peptide:
GQGSDD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
82-87
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
0.0
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-99.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.57
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0303 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0303
Peptide:
GQIVYK
Length:
6
Classification:
non-amyloid
Mutation(s):
V623G
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.06
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
34.6
Area of the profile Above Threshold (AGGRESCAN):
2.21
Best Energy Score (PASTA 2.0):
-3.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0304 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
G
L
T
P
K
N
G
V
H
I
E
T
G
P
D
T
E
S
S
A
D
S
S
N
F
S
T
G
F
S
G
K
I
R
K
P
R
S
K
V
S
K
A
C
D
N
C
R
K
R
K
I
K
C
N
G
K
F
60
61
P
C
A
S
C
E
I
Y
S
C
E
C
T
F
S
T
R
Q
G
G
A
R
I
K
N
L
H
K
T
S
L
E
G
T
T
V
Q
V
K
E
E
T
D
S
S
S
T
S
F
S
N
P
Q
R
C
T
D
G
P
C
120
121
A
V
E
Q
P
T
K
F
F
E
N
F
K
L
G
G
R
S
S
G
D
N
S
G
S
D
G
K
N
D
D
D
V
N
R
N
G
F
Y
E
D
D
S
E
S
Q
A
T
L
T
S
L
Q
T
T
L
K
N
L
K
180
181
E
M
A
H
L
G
T
H
V
T
S
A
I
E
S
I
E
L
Q
I
S
D
L
L
K
R
W
E
P
K
V
R
T
K
E
L
A
T
T
K
F
Y
P
N
K
S
I
E
T
Q
L
M
K
N
K
Y
C
D
V
V
240
241
H
L
T
R
Y
A
A
W
S
N
N
K
K
D
Q
D
T
S
S
Q
P
L
I
D
E
I
F
G
L
Y
S
P
F
Q
F
L
S
L
Q
G
I
G
K
C
F
Q
N
Y
R
S
K
S
K
C
E
I
F
P
R
T
300
301
A
K
E
T
I
Y
I
M
L
R
F
F
D
V
C
F
H
H
I
N
Q
G
C
V
S
I
A
N
P
L
E
N
Y
L
Q
K
M
N
L
L
P
S
T
P
S
S
I
S
S
A
G
S
P
N
T
A
H
T
K
S
360
361
H
V
A
L
V
I
N
H
L
P
Q
P
F
V
R
N
I
T
G
I
S
N
S
E
L
L
S
E
M
N
N
D
I
S
M
F
G
I
L
L
K
M
L
D
M
H
K
N
S
Y
Q
N
F
L
M
E
I
T
S
N
420
421
P
S
V
A
K
N
T
Q
S
I
D
V
L
Q
E
F
I
H
Y
C
Q
A
G
E
A
L
I
A
L
C
Y
S
Y
Y
N
S
T
L
Y
N
Y
V
D
F
T
C
D
I
T
H
L
E
Q
L
L
Y
F
L
D
L
480
481
L
F
W
L
S
E
I
Y
G
F
E
K
V
L
N
V
A
V
H
F
V
S
R
V
G
L
S
R
W
E
F
Y
V
G
L
D
E
N
F
A
E
R
R
R
N
L
W
W
K
A
F
Y
F
E
K
T
L
A
S
K
540
541
L
G
Y
P
S
N
I
D
D
S
K
I
N
C
L
L
P
K
N
F
R
D
V
G
F
L
D
N
R
D
F
I
E
N
V
H
L
V
R
R
S
E
A
F
D
N
M
C
I
S
D
L
K
Y
Y
G
E
L
A
V
600
601
L
Q
I
V
S
H
F
S
S
S
V
L
F
N
E
K
F
T
S
I
R
N
T
S
K
P
S
V
V
R
E
K
L
L
F
E
V
L
E
I
F
N
E
T
E
M
K
Y
D
A
I
K
E
Q
T
G
K
L
F
D
660
661
I
A
F
S
K
D
S
T
E
L
K
V
S
R
E
D
K
I
M
A
S
K
F
V
L
F
Y
E
H
H
F
C
R
M
V
N
E
S
D
N
I
V
A
R
L
C
V
H
R
R
P
S
I
L
I
E
N
L
K
I
720
721
Y
L
H
K
I
Y
K
S
W
T
D
M
N
K
I
L
L
D
F
D
N
D
Y
S
V
Y
R
S
F
A
H
Y
S
I
S
C
I
I
L
V
S
Q
A
F
S
V
A
E
F
I
K
V
N
D
V
V
N
M
I
R
780
781
V
F
K
R
F
L
D
I
K
I
F
S
E
N
E
T
N
E
H
V
F
N
S
Q
S
F
K
D
Y
T
R
A
F
S
F
L
T
I
V
T
R
I
M
L
L
A
Y
G
E
S
S
S
T
N
L
D
V
I
S
K
840
841
Y
I
D
E
N
A
P
D
L
K
G
I
I
E
L
V
L
D
T
N
S
C
A
Y
R
F
L
L
E
P
V
Q
K
S
G
F
H
L
T
V
S
Q
M
L
K
N
R
K
F
Q
E
P
L
M
S
N
E
D
N
K
900
901
Q
M
K
H
N
S
G
K
N
L
N
P
D
L
P
S
L
K
T
G
T
S
C
L
L
N
G
I
E
S
P
Q
L
P
F
N
G
R
S
A
P
S
P
V
R
N
N
S
L
P
E
F
A
Q
L
P
S
F
R
S
960
961
L
S
V
S
D
M
I
N
P
D
Y
A
Q
P
T
N
G
Q
N
N
T
Q
V
Q
S
N
K
P
I
N
A
Q
Q
Q
I
P
T
S
V
Q
V
P
F
M
N
T
N
E
I
N
N
N
N
N
N
N
N
N
N
K
1020
1021
N
N
I
N
N
I
N
N
N
N
S
N
N
F
S
A
T
S
F
N
L
G
T
L
D
E
F
V
N
N
G
D
L
E
D
L
Y
S
I
L
W
S
D
V
Y
P
D
S
1068
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0304
Peptide:
GQNNTQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P12383
UniProt Name:
PDR1_YEAST
Protein Name:
Transcription factor PDR1 (Pleiotropic drug resistance protein 1)
Position:
977-982
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-106.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.9
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0305 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0305
Peptide:
GQQNQY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
156-161
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-95.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0306 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0306
Peptide:
GQQQSY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
138-143
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-81.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.55
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0307 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0307
Peptide:
GQQSYS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
34-39
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-57.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.38
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0308 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0308
Peptide:
GQSSYS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
51-56
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-39.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.34
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0309 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0309
Peptide:
GRGNYK
Length:
6
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
Waltz-DB 2.0
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
16.67
NuAPRpred:
-0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-70.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.46
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0310 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0310
Peptide:
GRIGIA
Length:
6
Classification:
Non-amyloid
Mutation(s):
V149R
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
148-153
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.7
Area of the profile Above Threshold (AGGRESCAN):
1.51
Best Energy Score (PASTA 2.0):
-2.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0311 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0311
Peptide:
GSASNA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
386-391
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-51.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0312 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0312
Peptide:
GSGFNG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
394-399
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-25.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.12
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0313 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0313
Peptide:
GSGSGF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
392-397
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-33.5
Area of the profile Above Threshold (AGGRESCAN):
0.04
Best Energy Score (PASTA 2.0):
2.12
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0314 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0314
Peptide:
GSHLVE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
32-37
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.07
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.3
Area of the profile Above Threshold (AGGRESCAN):
0.31
Best Energy Score (PASTA 2.0):
-2.01
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0315 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0315
Peptide:
GSIAAT
Length:
6
Classification:
Amyloid
Mutation(s):
[del]89A
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
86-92
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.3
Area of the profile Above Threshold (AGGRESCAN):
0.73
Best Energy Score (PASTA 2.0):
-1.05
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0316 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
R
R
K
I
E
I
Q
R
I
S
D
D
R
N
R
A
V
T
F
I
K
R
K
A
G
L
F
K
K
A
H
E
L
S
V
L
C
Q
V
D
I
A
V
I
I
L
G
S
N
N
T
F
Y
E
F
S
S
V
60
61
D
T
N
D
L
I
Y
H
Y
Q
N
D
K
N
L
L
H
E
V
K
D
P
S
D
Y
G
D
F
H
K
S
A
S
V
N
I
N
Q
D
L
L
R
S
S
M
S
N
K
P
S
K
S
N
V
K
G
M
N
Q
S
120
121
E
N
D
D
D
E
N
N
D
E
D
D
D
D
H
G
N
F
E
R
N
S
N
M
H
S
N
K
K
A
S
D
K
N
I
P
S
A
H
M
K
L
L
S
P
T
A
L
I
S
K
M
D
G
S
E
Q
N
K
R
180
181
H
P
E
N
A
L
P
P
L
Q
H
L
K
R
L
K
P
D
P
L
Q
I
S
R
T
P
Q
Q
Q
Q
Q
Q
N
I
S
R
P
Y
H
S
S
M
Y
N
L
N
Q
P
S
S
S
S
S
S
P
S
T
M
D
F
240
241
P
K
L
P
S
F
Q
N
S
S
F
N
G
R
P
P
P
I
S
I
S
P
N
K
F
S
K
P
F
T
N
A
S
S
R
T
P
K
Q
E
H
K
I
N
N
S
G
S
N
N
N
D
N
S
N
Y
T
Q
S
P
300
301
S
N
S
L
E
D
S
I
Q
Q
T
V
K
A
R
R
K
L
S
A
R
P
V
L
R
V
R
I
P
N
N
N
F
S
S
N
S
A
I
P
S
E
P
S
S
A
S
S
T
S
A
N
G
N
S
M
G
S
S
Q
360
361
I
M
K
E
N
K
T
S
R
S
S
K
I
S
P
L
S
A
S
A
S
G
P
L
T
L
Q
K
G
N
N
G
R
M
V
I
K
L
P
N
A
N
A
P
N
G
S
N
N
G
N
G
S
N
N
N
N
H
P
Y
420
421
P
F
G
S
G
S
S
P
L
F
S
A
T
Q
P
Y
I
A
T
P
L
Q
P
S
N
I
P
G
G
P
F
Q
Q
N
T
S
F
L
A
Q
R
Q
T
Q
Q
Y
Q
Q
M
S
F
K
K
Q
S
Q
T
V
P
L
480
481
T
T
T
L
T
G
R
P
P
S
T
F
S
G
P
E
T
S
N
G
P
P
T
G
S
L
P
S
K
F
V
H
D
L
M
S
N
S
P
N
V
S
S
I
S
M
F
P
D
W
S
M
G
P
N
S
A
K
P
G
540
541
N
T
N
N
P
G
T
F
P
P
V
Q
T
A
V
N
N
G
N
S
S
N
I
S
S
T
N
N
T
N
N
N
N
N
N
N
N
N
N
S
S
N
N
N
S
N
N
G
N
D
N
N
S
N
N
S
N
N
S
Y
600
601
Y
S
N
N
E
D
A
P
V
N
G
A
A
I
S
E
H
T
T
D
G
D
S
N
N
Q
S
N
S
S
T
Y
D
A
A
A
T
A
Y
N
G
N
T
G
L
T
P
Y
I
N
T
A
Q
T
P
L
G
T
K
F
660
661
F
N
F
S
T
D
I
S
G
E
K
N
S
S
K
I
676
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0316
Peptide:
GSNNTF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12224
UniProt Name:
RLM1_YEAST
Protein Name:
Transcription factor RLM1
Position:
49-54
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-64.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0317 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0317
Peptide:
GSNSGA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
376-381
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-66.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.99
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0318 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
T
S
S
R
L
W
F
S
L
L
L
A
A
A
F
A
G
R
A
T
A
L
W
P
W
P
Q
N
F
Q
T
S
D
Q
R
Y
V
L
Y
P
N
N
F
Q
F
Q
Y
D
V
S
S
A
A
Q
P
G
C
S
V
60
61
L
D
E
A
F
Q
R
Y
R
D
L
L
F
G
S
G
S
W
P
R
P
Y
L
T
G
K
R
H
T
L
E
K
N
V
L
V
V
S
V
V
T
P
G
C
N
Q
L
P
T
L
E
S
V
E
N
Y
T
L
T
I
120
121
N
D
D
Q
C
L
L
L
S
E
T
V
W
G
A
L
R
G
L
E
T
F
S
Q
L
V
W
K
S
A
E
G
T
F
F
I
N
K
T
E
I
E
D
F
P
R
F
P
H
R
G
L
L
L
D
T
S
R
H
Y
180
181
L
P
L
S
S
I
L
D
T
L
D
V
M
A
Y
N
K
L
N
V
F
H
W
H
L
V
D
D
P
S
F
P
Y
E
S
F
T
F
P
E
L
M
R
K
G
S
Y
N
P
V
T
H
I
Y
T
A
Q
D
V
K
240
241
E
V
I
E
Y
A
R
L
R
G
I
R
V
L
A
E
F
D
T
P
G
H
T
L
S
W
G
P
G
I
P
G
L
L
T
P
C
Y
S
G
S
E
P
S
G
T
F
G
P
V
N
P
S
L
N
N
T
Y
E
F
300
301
M
S
T
F
F
L
E
V
S
S
V
F
P
D
F
Y
L
H
L
G
G
D
E
V
D
F
T
C
W
K
S
N
P
E
I
Q
D
F
M
R
K
K
G
F
G
E
D
F
K
Q
L
E
S
F
Y
I
Q
T
L
L
360
361
D
I
V
S
S
Y
G
K
G
Y
V
V
W
Q
E
V
F
D
N
K
V
K
I
Q
P
D
T
I
I
Q
V
W
R
E
D
I
P
V
N
Y
M
K
E
L
E
L
V
T
K
A
G
F
R
A
L
L
S
A
P
W
420
421
Y
L
N
R
I
S
Y
G
P
D
W
K
D
F
Y
I
V
E
P
L
A
F
E
G
T
P
E
Q
K
A
L
V
I
G
G
E
A
C
M
W
G
E
Y
V
D
N
T
N
L
V
P
R
L
W
P
R
A
G
A
V
480
481
A
E
R
L
W
S
N
K
L
T
S
D
L
T
F
A
Y
E
R
L
S
H
F
R
C
E
L
L
R
R
G
V
Q
A
Q
P
L
N
V
G
F
C
E
Q
E
F
E
Q
T
529
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0318
Peptide:
GTFFIN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06865
UniProt Name:
HEXA_HUMAN
Protein Name:
Beta-hexosaminidase subunit alpha
Position:
152-157
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
55.9
Area of the profile Above Threshold (AGGRESCAN):
3.6
Best Energy Score (PASTA 2.0):
-3.83
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0319 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
V
L
D
A
L
W
E
D
R
D
V
R
F
D
L
S
A
Q
Q
M
K
T
R
P
G
E
V
L
I
D
C
L
D
S
I
E
D
T
K
G
N
N
G
D
R
G
R
L
L
V
T
N
L
R
I
L
W
H
60
61
S
L
A
L
S
R
V
N
V
S
V
G
Y
N
C
I
L
N
I
T
T
R
T
A
N
S
K
L
R
G
Q
T
E
A
L
Y
I
L
T
K
C
N
S
T
R
F
E
F
I
F
T
N
L
V
P
G
S
P
R
L
120
121
F
T
S
V
M
A
V
H
R
A
Y
E
T
S
K
M
Y
R
D
F
K
L
R
S
A
L
I
Q
N
K
Q
L
R
L
L
P
Q
E
H
V
Y
D
K
I
N
G
V
W
N
L
S
S
D
Q
G
N
L
G
T
F
180
181
F
I
T
N
V
R
I
V
W
H
A
N
M
N
D
S
F
N
V
S
I
P
Y
L
Q
I
R
S
I
K
I
R
D
S
K
F
G
L
A
L
V
I
E
S
S
Q
Q
S
G
G
Y
V
L
G
F
K
I
D
P
V
240
241
E
K
L
Q
E
S
V
K
E
I
N
S
L
H
K
V
Y
S
A
S
P
I
F
G
V
D
Y
E
M
E
E
K
P
Q
P
L
E
A
L
T
V
E
Q
I
Q
D
D
V
E
I
D
S
D
G
H
T
D
A
F
V
300
301
A
Y
F
A
D
G
N
K
Q
Q
D
R
E
P
V
F
S
E
E
L
G
L
A
I
E
K
L
K
D
G
F
T
L
Q
G
L
W
E
V
M
S
341
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0319
Peptide:
GTFFIT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8N3I7
UniProt Name:
BBS5_HUMAN
Protein Name:
Bardet-Biedl syndrome 5 protein
Position:
178-183
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
67.3
Area of the profile Above Threshold (AGGRESCAN):
4.29
Best Energy Score (PASTA 2.0):
-4.07
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0320 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
W
N
M
L
I
V
A
M
C
L
A
L
L
G
C
L
Q
A
Q
E
L
Q
G
H
V
S
I
I
L
L
G
A
T
G
D
L
A
K
K
Y
L
W
Q
G
L
F
Q
L
Y
L
D
E
A
G
R
G
H
S
F
60
61
S
F
H
G
A
A
L
T
A
P
K
Q
G
Q
E
L
M
A
K
A
L
E
S
L
S
C
P
K
D
M
A
P
S
H
C
A
E
H
K
D
Q
F
L
Q
L
S
Q
Y
R
Q
L
K
T
A
E
D
Y
Q
A
L
120
121
N
K
D
I
E
A
Q
L
Q
H
A
G
L
R
E
A
G
R
I
F
Y
F
S
V
P
P
F
A
Y
E
D
I
A
R
N
I
N
S
S
C
R
P
G
P
G
A
W
L
R
V
V
L
E
K
P
F
G
H
D
H
180
181
F
S
A
Q
Q
L
A
T
E
L
G
T
F
F
Q
E
E
E
M
Y
R
V
D
H
Y
L
G
K
Q
A
V
A
Q
I
L
P
F
R
D
Q
N
R
K
A
L
D
G
L
W
N
R
H
H
V
E
R
V
E
I
I
240
241
M
K
E
T
V
D
A
E
G
R
T
S
F
Y
E
E
Y
G
V
I
R
D
V
L
Q
N
H
L
T
E
V
L
T
L
V
A
M
E
L
P
H
N
V
S
S
A
E
A
V
L
R
H
K
L
Q
V
F
Q
A
L
300
301
R
G
L
Q
R
G
S
A
V
V
G
Q
Y
Q
S
Y
S
E
Q
V
R
R
E
L
Q
K
P
D
S
F
H
S
L
T
P
T
F
A
A
V
L
V
H
I
D
N
L
R
W
E
G
V
P
F
I
L
M
S
G
K
360
361
A
L
D
E
R
V
G
Y
A
R
I
L
F
K
N
Q
A
C
C
V
Q
S
E
K
H
W
A
A
A
Q
S
Q
C
L
P
R
Q
L
V
F
H
I
G
H
G
D
L
G
S
P
A
V
L
V
S
R
N
L
F
R
420
421
P
S
L
P
S
S
W
K
E
M
E
G
P
P
G
L
R
L
F
G
S
P
L
S
D
Y
Y
A
Y
S
P
V
R
E
R
D
A
H
S
V
L
L
S
H
I
F
H
G
R
K
N
F
F
I
T
T
E
N
L
L
480
481
A
S
W
N
F
W
T
P
L
L
E
S
L
A
H
K
A
P
R
L
Y
P
G
G
A
E
N
G
R
L
L
D
F
E
F
S
S
G
R
L
F
F
S
Q
Q
Q
P
E
Q
L
V
P
G
P
G
P
A
P
M
P
540
541
S
D
F
Q
V
L
R
A
K
Y
R
E
S
P
L
V
S
A
W
S
E
E
L
I
S
K
L
A
N
D
I
E
A
T
A
V
R
A
V
R
R
F
G
Q
F
H
L
A
L
S
G
G
S
S
P
V
A
L
F
Q
600
601
Q
L
A
T
A
H
Y
G
F
P
W
A
H
T
H
L
W
L
V
D
E
R
C
V
P
L
S
D
P
E
S
N
F
Q
G
L
Q
A
H
L
L
Q
H
V
R
I
P
Y
Y
N
I
H
P
M
P
V
H
L
Q
Q
660
661
R
L
C
A
E
E
D
Q
G
A
Q
I
Y
A
R
E
I
S
A
L
V
A
N
S
S
F
D
L
V
L
L
G
M
G
A
D
G
H
T
A
S
L
F
P
Q
S
P
T
G
L
D
G
E
Q
L
V
V
L
T
T
720
721
S
P
S
Q
P
H
R
R
M
S
L
S
L
P
L
I
N
R
A
K
K
V
A
V
L
V
M
G
R
M
K
R
E
I
T
T
L
V
S
R
V
G
H
E
P
K
K
W
P
I
S
G
V
L
P
H
S
G
Q
L
780
781
V
W
Y
M
D
Y
D
A
F
L
G
791
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0320
Peptide:
GTFFQE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
O95479
UniProt Name:
G6PE_HUMAN
Protein Name:
GDH/6PGL endoplasmic bifunctional protein
Position:
191-196
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.1
Area of the profile Above Threshold (AGGRESCAN):
1.14
Best Energy Score (PASTA 2.0):
-2.3
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0321 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
P
P
A
A
P
A
R
L
A
L
A
L
G
L
G
L
W
L
G
A
L
A
G
G
P
G
R
G
C
G
P
C
E
P
P
C
L
C
G
P
A
P
G
A
A
C
R
V
N
C
S
G
R
G
L
R
T
L
G
60
61
P
A
L
R
I
P
A
D
A
T
A
L
D
V
S
H
N
L
L
R
A
L
D
V
G
L
L
A
N
L
S
A
L
A
E
L
D
I
S
N
N
K
I
S
T
L
E
E
G
I
F
A
N
L
F
N
L
S
E
I
120
121
N
L
S
G
N
P
F
E
C
D
C
G
L
A
W
L
P
R
W
A
E
E
Q
Q
V
R
V
V
Q
P
E
A
A
T
C
A
G
P
G
S
L
A
G
Q
P
L
L
G
I
P
L
L
D
S
G
C
G
E
E
Y
180
181
V
A
C
L
P
D
N
S
S
G
T
V
A
A
V
S
F
S
A
A
H
E
G
L
L
Q
P
E
A
C
S
A
F
C
F
S
T
G
Q
G
L
A
A
L
S
E
Q
G
W
C
L
C
G
A
A
Q
P
S
S
A
240
241
S
F
A
C
L
S
L
C
S
G
P
P
P
P
P
A
P
T
C
R
G
P
T
L
L
Q
H
V
F
P
A
S
P
G
A
T
L
V
G
P
H
G
P
L
A
S
G
Q
L
A
A
F
H
I
A
A
P
L
P
V
300
301
T
A
T
R
W
D
F
G
D
G
S
A
E
V
D
A
A
G
P
A
A
S
H
R
Y
V
L
P
G
R
Y
H
V
T
A
V
L
A
L
G
A
G
S
A
L
L
G
T
D
V
Q
V
E
A
A
P
A
A
L
E
360
361
L
V
C
P
S
S
V
Q
S
D
E
S
L
D
L
S
I
Q
N
R
G
G
S
G
L
E
A
A
Y
S
I
V
A
L
G
E
E
P
A
R
A
V
H
P
L
C
P
S
D
T
E
I
F
P
G
N
G
H
C
Y
420
421
R
L
V
V
E
K
A
A
W
L
Q
A
Q
E
Q
C
Q
A
W
A
G
A
A
L
A
M
V
D
S
P
A
V
Q
R
F
L
V
S
R
V
T
R
S
L
D
V
W
I
G
F
S
T
V
Q
G
V
E
V
G
P
480
481
A
P
Q
G
E
A
F
S
L
E
S
C
Q
N
W
L
P
G
E
P
H
P
A
T
A
E
H
C
V
R
L
G
P
T
G
W
C
N
T
D
L
C
S
A
P
H
S
Y
V
C
E
L
Q
P
G
G
P
V
Q
D
540
541
A
E
N
L
L
V
G
A
P
S
G
D
L
Q
G
P
L
T
P
L
A
Q
Q
D
G
L
S
A
P
H
E
P
V
E
V
M
V
F
P
G
L
R
L
S
R
E
A
F
L
T
T
A
E
F
G
T
Q
E
L
R
600
601
R
P
A
Q
L
R
L
Q
V
Y
R
L
L
S
T
A
G
T
P
E
N
G
S
E
P
E
S
R
S
P
D
N
R
T
Q
L
A
P
A
C
M
P
G
G
R
W
C
P
G
A
N
I
C
L
P
L
D
A
S
C
660
661
H
P
Q
A
C
A
N
G
C
T
S
G
P
G
L
P
G
A
P
Y
A
L
W
R
E
F
L
F
S
V
P
A
G
P
P
A
Q
Y
S
V
T
L
H
G
Q
D
V
L
M
L
P
G
D
L
V
G
L
Q
H
D
720
721
A
G
P
G
A
L
L
H
C
S
P
A
P
G
H
P
G
P
R
A
P
Y
L
S
A
N
A
S
S
W
L
P
H
L
P
A
Q
L
E
G
T
W
A
C
P
A
C
A
L
R
L
L
A
A
T
E
Q
L
T
V
780
781
L
L
G
L
R
P
N
P
G
L
R
L
P
G
R
Y
E
V
R
A
E
V
G
N
G
V
S
R
H
N
L
S
C
S
F
D
V
V
S
P
V
A
G
L
R
V
I
Y
P
A
P
R
D
G
R
L
Y
V
P
T
840
841
N
G
S
A
L
V
L
Q
V
D
S
G
A
N
A
T
A
T
A
R
W
P
G
G
S
V
S
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V
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A
L
V
A
T
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V
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G
C
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W
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D
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V
V
A
L
P
900
901
W
L
S
E
G
E
H
V
V
D
V
V
V
E
N
S
A
S
R
A
N
L
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L
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I
C
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L
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A
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S
P
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V
L
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G
V
L
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V
V
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G
960
961
S
D
M
V
F
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W
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D
K
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S
L
T
F
Q
N
V
V
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N
V
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A
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L
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L
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N
H
V
S
N
V
T
V
N
Y
N
V
T
V
E
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M
N
R
M
Q
1020
1021
G
L
Q
V
S
T
V
P
A
V
L
S
P
N
A
T
L
A
L
T
A
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V
L
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G
E
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A
L
H
Q
F
Q
P
P
Y
N
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F
P
V
P
D
P
1080
1081
S
V
A
Q
V
L
V
E
H
N
V
M
H
T
Y
A
A
P
G
E
Y
L
L
T
V
L
A
S
N
A
F
E
N
L
T
Q
Q
V
P
V
S
V
R
A
S
L
P
S
V
A
V
G
V
S
D
G
V
L
V
A
1140
1141
G
R
P
V
T
F
Y
P
H
P
L
P
S
P
G
G
V
L
Y
T
W
D
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D
G
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P
V
L
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S
Q
P
A
A
N
H
T
Y
A
S
R
G
T
Y
H
V
R
L
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V
N
N
T
V
S
G
A
1200
1201
A
A
Q
A
D
V
R
V
F
E
E
L
R
G
L
S
V
D
M
S
L
A
V
E
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G
A
P
V
V
V
S
A
A
V
Q
T
G
D
N
I
T
W
T
F
D
M
G
D
G
T
V
L
S
G
P
E
A
T
V
1260
1261
E
H
V
Y
L
R
A
Q
N
C
T
V
T
V
G
A
A
S
P
A
G
H
L
A
R
S
L
H
V
L
V
F
V
L
E
V
L
R
V
E
P
A
A
C
I
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T
Q
P
D
A
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L
T
A
Y
V
T
G
N
1320
1321
P
A
H
Y
L
F
D
W
T
F
G
D
G
S
S
N
T
T
V
R
G
C
P
T
V
T
H
N
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G
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P
L
A
L
V
L
S
S
R
V
N
R
A
H
Y
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I
C
V
E
P
E
V
1380
1381
G
N
V
T
L
Q
P
E
R
Q
F
V
Q
L
G
D
E
A
W
L
V
A
C
A
W
P
P
F
P
Y
R
Y
T
W
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F
G
T
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E
A
A
P
T
R
A
R
G
P
E
V
T
F
I
Y
R
D
P
G
S
1440
1441
Y
L
V
T
V
T
A
S
N
N
I
S
A
A
N
D
S
A
L
V
E
V
Q
E
P
V
L
V
T
S
I
K
V
N
G
S
L
G
L
E
L
Q
Q
P
Y
L
F
S
A
V
G
R
G
R
P
A
S
Y
L
W
1500
1501
D
L
G
D
G
G
W
L
E
G
P
E
V
T
H
A
Y
N
S
T
G
D
F
T
V
R
V
A
G
W
N
E
V
S
R
S
E
A
W
L
N
V
T
V
K
R
R
V
R
G
L
V
V
N
A
S
R
T
V
V
1560
1561
P
L
N
G
S
V
S
F
S
T
S
L
E
A
G
S
D
V
R
Y
S
W
V
L
C
D
R
C
T
P
I
P
G
G
P
T
I
S
Y
T
F
R
S
V
G
T
F
N
I
I
V
T
A
E
N
E
V
G
S
A
1620
1621
Q
D
S
I
F
V
Y
V
L
Q
L
I
E
G
L
Q
V
V
G
G
G
R
Y
F
P
T
N
H
T
V
Q
L
Q
A
V
V
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D
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T
N
V
S
Y
S
W
T
A
W
R
D
R
G
P
A
L
A
G
S
G
1680
1681
K
G
F
S
L
T
V
L
E
A
G
T
Y
H
V
Q
L
R
A
T
N
M
L
G
S
A
W
A
D
C
T
M
D
F
V
E
P
V
G
W
L
M
V
A
A
S
P
N
P
A
A
V
N
T
S
V
T
L
S
A
1740
1741
E
L
A
G
G
S
G
V
V
Y
T
W
S
L
E
E
G
L
S
W
E
T
S
E
P
F
T
T
H
S
F
P
T
P
G
L
H
L
V
T
M
T
A
G
N
P
L
G
S
A
N
A
T
V
E
V
D
V
Q
V
1800
1801
P
V
S
G
L
S
I
R
A
S
E
P
G
G
S
F
V
A
A
G
S
S
V
P
F
W
G
Q
L
A
T
G
T
N
V
S
W
C
W
A
V
P
G
G
S
S
K
R
G
P
H
V
T
M
V
F
P
D
A
G
1860
1861
T
F
S
I
R
L
N
A
S
N
A
V
S
W
V
S
A
T
Y
N
L
T
A
E
E
P
I
V
G
L
V
L
W
A
S
S
K
V
V
A
P
G
Q
L
V
H
F
Q
I
L
L
A
A
G
S
A
V
T
F
R
1920
1921
L
Q
V
G
G
A
N
P
E
V
L
P
G
P
R
F
S
H
S
F
P
R
V
G
D
H
V
V
S
V
R
G
K
N
H
V
S
W
A
Q
A
Q
V
R
I
V
V
L
E
A
V
S
G
L
Q
V
P
N
C
C
1980
1981
E
P
G
I
A
T
G
T
E
R
N
F
T
A
R
V
Q
R
G
S
R
V
A
Y
A
W
Y
F
S
L
Q
K
V
Q
G
D
S
L
V
I
L
S
G
R
D
V
T
Y
T
P
V
A
A
G
L
L
E
I
Q
V
2040
2041
R
A
F
N
A
L
G
S
E
N
R
T
L
V
L
E
V
Q
D
A
V
Q
Y
V
A
L
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N
R
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A
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E
A
A
T
S
P
S
P
R
R
V
A
Y
H
W
D
F
G
D
G
S
2100
2101
P
G
Q
D
T
D
E
P
R
A
E
H
S
Y
L
R
P
G
D
Y
R
V
Q
V
N
A
S
N
L
V
S
F
F
V
A
Q
A
T
V
T
V
Q
V
L
A
C
R
E
P
E
V
D
V
V
L
P
L
Q
V
L
2160
2161
M
R
R
S
Q
R
N
Y
L
E
A
H
V
D
L
R
D
C
V
T
Y
Q
T
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W
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Y
R
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R
P
A
R
V
A
L
P
G
V
D
V
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R
L
V
L
P
R
2220
2221
L
A
L
P
V
G
H
Y
C
F
V
F
V
V
S
F
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L
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L
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G
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W
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L
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2280
2281
S
Y
D
P
N
L
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D
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D
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L
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F
H
W
A
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A
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T
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A
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L
2340
2341
T
V
W
K
A
G
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A
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L
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Y
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Y
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L
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C
S
S
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2400
2401
K
R
G
R
W
A
A
R
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F
S
N
K
T
L
V
L
D
E
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T
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A
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R
L
V
L
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R
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L
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D
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C
2460
2461
A
S
I
R
L
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P
N
R
P
P
L
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G
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C
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L
L
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R
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R
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2520
2521
H
C
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E
F
C
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K
G
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L
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A
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L
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P
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2580
2581
A
T
G
L
T
V
W
L
H
G
L
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A
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L
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G
L
L
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N
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R
A
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V
A
A
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H
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Q
H
R
A
2640
2641
Q
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K
N
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L
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D
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L
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M
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L
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A
2700
2701
E
T
T
A
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T
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2760
2761
R
I
L
M
R
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R
V
L
N
E
E
P
L
T
L
A
G
E
E
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L
L
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G
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2820
2821
D
V
V
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N
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F
P
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N
S
2880
2881
D
W
A
A
R
G
H
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S
A
N
S
A
N
S
V
V
V
Q
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A
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V
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P
A
A
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H
L
Q
L
N
Y
T
L
L
D
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Y
L
S
E
E
P
E
P
2940
2941
Y
L
A
V
Y
L
H
S
E
P
R
P
N
E
H
N
C
S
A
S
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L
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A
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L
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S
H
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3000
3001
W
S
A
L
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V
G
L
Y
T
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L
C
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E
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M
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L
L
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L
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A
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C
L
T
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H
L
T
A
F
G
A
S
L
F
V
P
P
S
3060
3061
H
V
R
F
V
F
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E
P
T
A
D
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N
Y
I
V
M
L
T
C
A
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C
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V
M
A
A
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L
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L
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R
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A
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R
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3120
3121
E
I
L
V
K
T
G
W
G
R
G
S
G
T
T
A
H
V
G
I
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3180
3181
K
I
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A
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L
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H
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G
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A
3240
3241
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L
L
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R
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L
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3300
3301
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3360
3361
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L
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3420
3421
P
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L
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3480
3481
V
S
S
P
A
P
T
Q
D
T
H
M
E
T
D
L
L
S
S
L
S
S
T
P
G
E
K
T
E
T
L
A
L
Q
R
L
G
E
L
G
P
P
S
P
G
L
N
W
E
Q
P
Q
A
A
R
L
S
R
T
G
3540
3541
L
V
E
G
L
R
K
R
L
L
P
A
W
C
A
S
L
A
H
G
L
S
L
L
L
V
A
V
A
V
A
V
S
G
W
V
G
A
S
F
P
P
G
V
S
V
A
W
L
L
S
S
S
A
S
F
L
A
S
F
3600
3601
L
G
W
E
P
L
K
V
L
L
E
A
L
Y
F
S
L
V
A
K
R
L
H
P
D
E
D
D
T
L
V
E
S
P
A
V
T
P
V
S
A
R
V
P
R
V
R
P
P
H
G
F
A
L
F
L
A
K
E
E
3660
3661
A
R
K
V
K
R
L
H
G
M
L
R
S
L
L
V
Y
M
L
F
L
L
V
T
L
L
A
S
Y
G
D
A
S
C
H
G
H
A
Y
R
L
Q
S
A
I
K
Q
E
L
H
S
R
A
F
L
A
I
T
R
S
3720
3721
E
E
L
W
P
W
M
A
H
V
L
L
P
Y
V
H
G
N
Q
S
S
P
E
L
G
P
P
R
L
R
Q
V
R
L
Q
E
A
L
Y
P
D
P
P
G
P
R
V
H
T
C
S
A
A
G
G
F
S
T
S
D
3780
3781
Y
D
V
G
W
E
S
P
H
N
G
S
G
T
W
A
Y
S
A
P
D
L
L
G
A
W
S
W
G
S
C
A
V
Y
D
S
G
G
Y
V
Q
E
L
G
L
S
L
E
E
S
R
D
R
L
R
F
L
Q
L
H
3840
3841
N
W
L
D
N
R
S
R
A
V
F
L
E
L
T
R
Y
S
P
A
V
G
L
H
A
A
V
T
L
R
L
E
F
P
A
A
G
R
A
L
A
A
L
S
V
R
P
F
A
L
R
R
L
S
A
G
L
S
L
P
3900
3901
L
L
T
S
V
C
L
L
L
F
A
V
H
F
A
V
A
E
A
R
T
W
H
R
E
G
R
W
R
V
L
R
L
G
A
W
A
R
W
L
L
V
A
L
T
A
A
T
A
L
V
R
L
A
Q
L
G
A
A
D
3960
3961
R
Q
W
T
R
F
V
R
G
R
P
R
R
F
T
S
F
D
Q
V
A
Q
L
S
S
A
A
R
G
L
A
A
S
L
L
F
L
L
L
V
K
A
A
Q
Q
L
R
F
V
R
Q
W
S
V
F
G
K
T
L
C
4020
4021
R
A
L
P
E
L
L
G
V
T
L
G
L
V
V
L
G
V
A
Y
A
Q
L
A
I
L
L
V
S
S
C
V
D
S
L
W
S
V
A
Q
A
L
L
V
L
C
P
G
T
G
L
S
T
L
C
P
A
E
S
W
4080
4081
H
L
S
P
L
L
C
V
G
L
W
A
L
R
L
W
G
A
L
R
L
G
A
V
I
L
R
W
R
Y
H
A
L
R
G
E
L
Y
R
P
A
W
E
P
Q
D
Y
E
M
V
E
L
F
L
R
R
L
R
L
W
4140
4141
M
G
L
S
K
V
K
E
F
R
H
K
V
R
F
E
G
M
E
P
L
P
S
R
S
S
R
G
S
K
V
S
P
D
V
P
P
P
S
A
G
S
D
A
S
H
P
S
T
S
S
S
Q
L
D
G
L
S
V
S
4200
4201
L
G
R
L
G
T
R
C
E
P
E
P
S
R
L
Q
A
V
F
E
A
L
L
T
Q
F
D
R
L
N
Q
A
T
E
D
V
Y
Q
L
E
Q
Q
L
H
S
L
Q
G
R
R
S
S
R
A
P
A
G
S
S
R
4260
4261
G
P
S
P
G
L
R
P
A
L
P
S
R
L
A
R
A
S
R
G
V
D
L
A
T
G
P
S
R
T
P
L
R
A
K
N
K
V
H
P
S
S
T
4303
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0321
Peptide:
GTFNII
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P98161
UniProt Name:
PKD1_HUMAN
Protein Name:
Polycystin-1 (PC1)
Position:
1605-1610
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.72
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
26.0
Area of the profile Above Threshold (AGGRESCAN):
2.39
Best Energy Score (PASTA 2.0):
-4.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0322 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0322
Peptide:
GTFSIN
Length:
6
Classification:
Non-amyloid
Mutation(s):
A315T
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
314-319
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.07
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.9
Area of the profile Above Threshold (AGGRESCAN):
1.32
Best Energy Score (PASTA 2.0):
-2.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0323 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
G
T
L
F
W
G
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0323
Peptide:
GTLFWG
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
25133634
Reference:
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
45.6
Area of the profile Above Threshold (AGGRESCAN):
2.95
Best Energy Score (PASTA 2.0):
-2.63
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0324 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0324
Peptide:
GTLVFM
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
66.4
Area of the profile Above Threshold (AGGRESCAN):
4.18
Best Energy Score (PASTA 2.0):
-3.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0325 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0325
Peptide:
GTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.72
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
53.0
Area of the profile Above Threshold (AGGRESCAN):
3.42
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0326 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
M
S
P
A
L
T
C
L
V
L
G
L
A
L
V
F
G
E
G
S
A
V
H
H
P
P
S
Y
V
A
H
L
A
S
D
F
G
V
R
V
F
Q
Q
V
A
Q
A
S
K
D
R
N
V
V
F
S
P
Y
60
61
G
V
A
S
V
L
A
M
L
Q
L
T
T
G
G
E
T
Q
Q
Q
I
Q
A
A
M
G
F
K
I
D
D
K
G
M
A
P
A
L
R
H
L
Y
K
E
L
M
G
P
W
N
K
D
E
I
S
T
T
D
A
I
120
121
F
V
Q
R
D
L
K
L
V
Q
G
F
M
P
H
F
F
R
L
F
R
S
T
V
K
Q
V
D
F
S
E
V
E
R
A
R
F
I
I
N
D
W
V
K
T
H
T
K
G
M
I
S
N
L
L
G
K
G
A
V
180
181
D
Q
L
T
R
L
V
L
V
N
A
L
Y
F
N
G
Q
W
K
T
P
F
P
D
S
S
T
H
R
R
L
F
H
K
S
D
G
S
T
V
S
V
P
M
M
A
Q
T
N
K
F
N
Y
T
E
F
T
T
P
D
240
241
G
H
Y
Y
D
I
L
E
L
P
Y
H
G
D
T
L
S
M
F
I
A
A
P
Y
E
K
E
V
P
L
S
A
L
T
N
I
L
S
A
Q
L
I
S
H
W
K
G
N
M
T
R
L
P
R
L
L
V
L
P
K
300
301
F
S
L
E
T
E
V
D
L
R
K
P
L
E
N
L
G
M
T
D
M
F
R
Q
F
Q
A
D
F
T
S
L
S
D
Q
E
P
L
H
V
A
Q
A
L
Q
K
V
K
I
E
V
N
E
S
G
T
V
A
S
S
360
361
S
T
A
V
I
V
S
A
R
M
A
P
E
E
I
I
M
D
R
P
F
L
F
V
V
R
H
N
P
T
G
T
V
L
F
M
G
Q
V
M
E
P
402
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0326
Peptide:
GTVLFM
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05121
UniProt Name:
PAI1_HUMAN
Protein Name:
Plasminogen activator inhibitor 1 (PAI)
Position:
391-396
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
66.4
Area of the profile Above Threshold (AGGRESCAN):
4.18
Best Energy Score (PASTA 2.0):
-3.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0327 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
G
T
V
W
W
G
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0327
Peptide:
GTVWWG
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
25133634
Reference:
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.34
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.6
Area of the profile Above Threshold (AGGRESCAN):
2.29
Best Energy Score (PASTA 2.0):
-3.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0328 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0328
Peptide:
GVATVA
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
51-56
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.8
Area of the profile Above Threshold (AGGRESCAN):
1.27
Best Energy Score (PASTA 2.0):
-3.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0329 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
E
G
G
G
K
P
N
S
S
S
N
S
R
D
D
G
N
S
V
F
P
A
K
A
S
A
T
G
A
G
P
A
A
A
E
K
R
L
G
T
P
P
G
G
G
G
A
G
A
K
E
H
G
N
S
V
C
F
K
60
61
V
D
G
G
G
G
G
G
G
G
G
G
G
G
E
E
P
A
G
G
F
E
D
A
E
G
P
R
R
Q
Y
G
F
M
Q
R
Q
F
T
S
M
L
Q
P
G
V
N
K
F
S
L
R
M
F
G
S
Q
K
A
V
120
121
E
K
E
Q
E
R
V
K
T
A
G
F
W
I
I
H
P
Y
S
D
F
R
F
Y
W
D
L
I
M
L
I
M
M
V
G
N
L
V
I
I
P
V
G
I
T
F
F
T
E
Q
T
T
T
P
W
I
I
F
N
V
180
181
A
S
D
T
V
F
L
L
D
L
I
M
N
F
R
T
G
T
V
N
E
D
S
S
E
I
I
L
D
P
K
V
I
K
M
N
Y
L
K
S
W
F
V
V
D
F
I
S
S
I
P
V
D
Y
I
F
L
I
V
E
240
241
K
G
M
D
S
E
V
Y
K
T
A
R
A
L
R
I
V
R
F
T
K
I
L
S
L
L
R
L
L
R
L
S
R
L
I
R
Y
I
H
Q
W
E
E
I
F
H
M
T
Y
D
L
A
S
A
V
V
R
I
F
N
300
301
L
I
G
M
M
L
L
L
C
H
W
D
G
C
L
Q
F
L
V
P
L
L
Q
D
F
P
P
D
C
W
V
S
L
N
E
M
V
N
D
S
W
G
K
Q
Y
S
Y
A
L
F
K
A
M
S
H
M
L
C
I
G
360
361
Y
G
A
Q
A
P
V
S
M
S
D
L
W
I
T
M
L
S
M
I
V
G
A
T
C
Y
A
M
F
V
G
H
A
T
A
L
I
Q
S
L
D
S
S
R
R
Q
Y
Q
E
K
Y
K
Q
V
E
Q
Y
M
S
F
420
421
H
K
L
P
A
D
M
R
Q
K
I
H
D
Y
Y
E
H
R
Y
Q
G
K
I
F
D
E
E
N
I
L
N
E
L
N
D
P
L
R
E
E
I
V
N
F
N
C
R
K
L
V
A
T
M
P
L
F
A
N
A
D
480
481
P
N
F
V
T
A
M
L
S
K
L
R
F
E
V
F
Q
P
G
D
Y
I
I
R
E
G
A
V
G
K
K
M
Y
F
I
Q
H
G
V
A
G
V
I
T
K
S
S
K
E
M
K
L
T
D
G
S
Y
F
G
E
540
541
I
C
L
L
T
K
G
R
R
T
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
S
V
D
N
F
N
E
V
L
E
E
Y
P
M
M
R
R
A
F
E
T
V
A
I
D
R
L
D
R
I
G
K
K
N
S
I
600
601
L
L
Q
K
F
Q
K
D
L
N
T
G
V
F
N
N
Q
E
N
E
I
L
K
Q
I
V
K
H
D
R
E
M
V
Q
A
I
A
P
I
N
Y
P
Q
M
T
T
L
N
S
T
S
S
T
T
T
P
T
S
R
M
660
661
R
T
Q
S
P
P
V
Y
T
A
T
S
L
S
H
S
N
L
H
S
P
S
P
S
T
Q
T
P
Q
P
S
A
I
L
S
P
C
S
Y
T
T
A
V
C
S
P
P
V
Q
S
P
L
A
A
R
T
F
H
Y
A
720
721
S
P
T
A
S
Q
L
S
L
M
Q
Q
Q
P
Q
Q
Q
V
Q
Q
S
Q
P
P
Q
T
Q
P
Q
Q
P
S
P
Q
P
Q
T
P
G
S
S
T
P
K
N
E
V
H
K
S
T
Q
A
L
H
N
T
N
L
T
780
781
R
E
V
R
P
L
S
A
S
Q
P
S
L
P
H
E
V
S
T
L
I
S
R
P
H
P
T
V
G
E
S
L
A
S
I
P
Q
P
V
T
A
V
P
G
T
G
L
Q
A
G
G
R
S
T
V
P
Q
R
V
T
840
841
L
F
R
Q
M
S
S
G
A
I
P
P
N
R
G
V
P
P
A
P
P
P
P
A
A
A
L
P
R
E
S
S
S
V
L
N
T
D
P
D
A
E
K
P
R
F
A
S
N
L
890
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0329
Peptide:
GVFNNQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
O60741
UniProt Name:
HCN1_HUMAN
Protein Name:
Brain cyclic nucleotide-gated channel 1 (BCNG-1)
Position:
612-617
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.08
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-22.8
Area of the profile Above Threshold (AGGRESCAN):
0.06
Best Energy Score (PASTA 2.0):
-2.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0330 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0330
Peptide:
GVIGIA
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
148-153
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.88
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
47.5
Area of the profile Above Threshold (AGGRESCAN):
3.05
Best Energy Score (PASTA 2.0):
-4.61
Aggregate Orientation (PASTA 2.0):
Parallel
