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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 481 to 510 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0481
KTKEGV
6
Amyloid
Alpha-synuclein
P37840
No
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6.
8248242
CPAD, Waltz-DB 2.0
P-0482
KTKEQV
6
Amyloid
Alpha-synuclein
P37840
No
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6.
8248242
CPAD, Waltz-DB 2.0
P-0483
KTKQGV
6
Amyloid
Alpha-synuclein
P37840
No
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6.
8248242
CPAD, Waltz-DB 2.0
P-0484
KTLKLV
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0485
KTVEGA
6
Amyloid
Alpha-synuclein
P37840
No
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6.
8248242
CPAD, Waltz-DB 2.0
P-0486
KTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0487
KTVIIT
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0488
KTVIVE
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0489
KTVIYE
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0490
KTVLIE
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0491
KVDTKP
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
G162D
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0492
KVEDLK
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0493
KVEEPV
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0494
KVEHSD
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0495
KVKVLG
6
Amyloid
Alpha-crystallin B chain (Alpha(B)-crystallin)
P02511
No
Science. 2012 Mar 9;335(6073):1228-31.
22403391
AmyLoad
P-0496
KVQIIN
6
Amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0497
KWDRDM
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0498
KYLNWD
6
Non-amyloid
Serine-protein kinase ATM
Q13315
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0499
KYNNTG
6
Non-amyloid
Uncharacterized protein YBL081W
P38180
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0500
LAAVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40A
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0501
LACVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40C
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0502
LADVYV
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40D
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0503
LAEAIG
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0504
LAEVYV
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40E
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0505
LAFVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40F
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0506
LAGVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40G
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0507
LAHVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40H
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0508
LAIVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40I
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0509
LAKVYV
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
T40K
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0510
LALQTD
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0481 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0481
Peptide:
KTKEGV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
43-48
Literature
PMID:
8248242
Reference:
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-67.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.71
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0482 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0482
Peptide:
KTKEQV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
58-63
Literature
PMID:
8248242
Reference:
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.17
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-76.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.89
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0483 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0483
Peptide:
KTKQGV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
21-26
Literature
PMID:
8248242
Reference:
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
16.67
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-63.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.22
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0484 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0484
Peptide:
KTLKLV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
142-147
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.12
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.8
Area of the profile Above Threshold (AGGRESCAN):
1.82
Best Energy Score (PASTA 2.0):
-2.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0485 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0485
Peptide:
KTVEGA
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
80-85
Literature
PMID:
8248242
Reference:
Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11282-6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-33.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.15
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0486 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0486
Peptide:
KTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
49.0
Area of the profile Above Threshold (AGGRESCAN):
3.14
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0487 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0487
Peptide:
KTVIIT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.28
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
61.5
Area of the profile Above Threshold (AGGRESCAN):
3.89
Best Energy Score (PASTA 2.0):
-6.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0488 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0488
Peptide:
KTVIVE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.28
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.0
Area of the profile Above Threshold (AGGRESCAN):
2.96
Best Energy Score (PASTA 2.0):
-6.06
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0489 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0489
Peptide:
KTVIYE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-0.04
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.2
Area of the profile Above Threshold (AGGRESCAN):
2.61
Best Energy Score (PASTA 2.0):
-4.49
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0490 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0490
Peptide:
KTVLIE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.16
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.2
Area of the profile Above Threshold (AGGRESCAN):
2.57
Best Energy Score (PASTA 2.0):
-4.81
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0491 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0491
Peptide:
KVDTKP
Length:
6
Classification:
Non-amyloid
Mutation(s):
G162D
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
160-165
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
33.33
NuAPRpred:
-0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.74
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0492 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0492
Peptide:
KVEDLK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
214-219
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
33.33
NuAPRpred:
-0.04
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-62.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.24
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0493 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0493
Peptide:
KVEEPV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
188-193
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-51.1
Area of the profile Above Threshold (AGGRESCAN):
0.03
Best Energy Score (PASTA 2.0):
-0.16
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0494 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0494
Peptide:
KVEHSD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
68-73
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.27
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-77.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.66
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0495 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
I
A
I
H
H
P
W
I
R
R
P
F
F
P
F
H
S
P
S
R
L
F
D
Q
F
F
G
E
H
L
L
E
S
D
L
F
P
T
S
T
S
L
S
P
F
Y
L
R
P
P
S
F
L
R
A
P
S
W
60
61
F
D
T
G
L
S
E
M
R
L
E
K
D
R
F
S
V
N
L
D
V
K
H
F
S
P
E
E
L
K
V
K
V
L
G
D
V
I
E
V
H
G
K
H
E
E
R
Q
D
E
H
G
F
I
S
R
E
F
H
R
120
121
K
Y
R
I
P
A
D
V
D
P
L
T
I
T
S
S
L
S
S
D
G
V
L
T
V
N
G
P
R
K
Q
V
S
G
P
E
R
T
I
P
I
T
R
E
E
K
P
A
V
T
A
A
P
K
K
175
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0495
Peptide:
KVKVLG
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02511
UniProt Name:
CRYAB_HUMAN
Protein Name:
Alpha-crystallin B chain (Alpha(B)-crystallin)
Position:
90-95
Literature
PMID:
22403391
Reference:
Science. 2012 Mar 9;335(6073):1228-31.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
20.2
Area of the profile Above Threshold (AGGRESCAN):
1.41
Best Energy Score (PASTA 2.0):
-3.43
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0496 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0496
Peptide:
KVQIIN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
591-596
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
17.0
Area of the profile Above Threshold (AGGRESCAN):
1.25
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0497 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0497
Peptide:
KWDRDM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
114-119
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
33.33
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-90.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.39
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0498 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
L
V
L
N
D
L
L
I
C
C
R
Q
L
E
H
D
R
A
T
E
R
K
K
E
V
E
K
F
K
R
L
I
R
D
P
E
T
I
K
H
L
D
R
H
S
D
S
K
Q
G
K
Y
L
N
W
D
A
V
60
61
F
R
F
L
Q
K
Y
I
Q
K
E
T
E
C
L
R
I
A
K
P
N
V
S
A
S
T
Q
A
S
R
Q
K
K
M
Q
E
I
S
S
L
V
K
Y
F
I
K
C
A
N
R
R
A
P
R
L
K
C
Q
E
L
120
121
L
N
Y
I
M
D
T
V
K
D
S
S
N
G
A
I
Y
G
A
D
C
S
N
I
L
L
K
D
I
L
S
V
R
K
Y
W
C
E
I
S
Q
Q
Q
W
L
E
L
F
S
V
Y
F
R
L
Y
L
K
P
S
Q
180
181
D
V
H
R
V
L
V
A
R
I
I
H
A
V
T
K
G
C
C
S
Q
T
D
G
L
N
S
K
F
L
D
F
F
S
K
A
I
Q
C
A
R
Q
E
K
S
S
S
G
L
N
H
I
L
A
A
L
T
I
F
L
240
241
K
T
L
A
V
N
F
R
I
R
V
C
E
L
G
D
E
I
L
P
T
L
L
Y
I
W
T
Q
H
R
L
N
D
S
L
K
E
V
I
I
E
L
F
Q
L
Q
I
Y
I
H
H
P
K
G
A
K
T
Q
E
K
300
301
G
A
Y
E
S
T
K
W
R
S
I
L
Y
N
L
Y
D
L
L
V
N
E
I
S
H
I
G
S
R
G
K
Y
S
S
G
F
R
N
I
A
V
K
E
N
L
I
E
L
M
A
D
I
C
H
Q
V
F
N
E
D
360
361
T
R
S
L
E
I
S
Q
S
Y
T
T
T
Q
R
E
S
S
D
Y
S
V
P
C
K
R
K
K
I
E
L
G
W
E
V
I
K
D
H
L
Q
K
S
Q
N
D
F
D
L
V
P
W
L
Q
I
A
T
Q
L
I
420
421
S
K
Y
P
A
S
L
P
N
C
E
L
S
P
L
L
M
I
L
S
Q
L
L
P
Q
Q
R
H
G
E
R
T
P
Y
V
L
R
C
L
T
E
V
A
L
C
Q
D
K
R
S
N
L
E
S
S
Q
K
S
D
L
480
481
L
K
L
W
N
K
I
W
C
I
T
F
R
G
I
S
S
E
Q
I
Q
A
E
N
F
G
L
L
G
A
I
I
Q
G
S
L
V
E
V
D
R
E
F
W
K
L
F
T
G
S
A
C
R
P
S
C
P
A
V
C
540
541
C
L
T
L
A
L
T
T
S
I
V
P
G
T
V
K
M
G
I
E
Q
N
M
C
E
V
N
R
S
F
S
L
K
E
S
I
M
K
W
L
L
F
Y
Q
L
E
G
D
L
E
N
S
T
E
V
P
P
I
L
H
600
601
S
N
F
P
H
L
V
L
E
K
I
L
V
S
L
T
M
K
N
C
K
A
A
M
N
F
F
Q
S
V
P
E
C
E
H
H
Q
K
D
K
E
E
L
S
F
S
E
V
E
E
L
F
L
Q
T
T
F
D
K
M
660
661
D
F
L
T
I
V
R
E
C
G
I
E
K
H
Q
S
S
I
G
F
S
V
H
Q
N
L
K
E
S
L
D
R
C
L
L
G
L
S
E
Q
L
L
N
N
Y
S
S
E
I
T
N
S
E
T
L
V
R
C
S
R
720
721
L
L
V
G
V
L
G
C
Y
C
Y
M
G
V
I
A
E
E
E
A
Y
K
S
E
L
F
Q
K
A
K
S
L
M
Q
C
A
G
E
S
I
T
L
F
K
N
K
T
N
E
E
F
R
I
G
S
L
R
N
M
M
780
781
Q
L
C
T
R
C
L
S
N
C
T
K
K
S
P
N
K
I
A
S
G
F
F
L
R
L
L
T
S
K
L
M
N
D
I
A
D
I
C
K
S
L
A
S
F
I
K
K
P
F
D
R
G
E
V
E
S
M
E
D
840
841
D
T
N
G
N
L
M
E
V
E
D
Q
S
S
M
N
L
F
N
D
Y
P
D
S
S
V
S
D
A
N
E
P
G
E
S
Q
S
T
I
G
A
I
N
P
L
A
E
E
Y
L
S
K
Q
D
L
L
F
L
D
M
900
901
L
K
F
L
C
L
C
V
T
T
A
Q
T
N
T
V
S
F
R
A
A
D
I
R
R
K
L
L
M
L
I
D
S
S
T
L
E
P
T
K
S
L
H
L
H
M
Y
L
M
L
L
K
E
L
P
G
E
E
Y
P
960
961
L
P
M
E
D
V
L
E
L
L
K
P
L
S
N
V
C
S
L
Y
R
R
D
Q
D
V
C
K
T
I
L
N
H
V
L
H
V
V
K
N
L
G
Q
S
N
M
D
S
E
N
T
R
D
A
Q
G
Q
F
L
T
1020
1021
V
I
G
A
F
W
H
L
T
K
E
R
K
Y
I
F
S
V
R
M
A
L
V
N
C
L
K
T
L
L
E
A
D
P
Y
S
K
W
A
I
L
N
V
M
G
K
D
F
P
V
N
E
V
F
T
Q
F
L
A
D
1080
1081
N
H
H
Q
V
R
M
L
A
A
E
S
I
N
R
L
F
Q
D
T
K
G
D
S
S
R
L
L
K
A
L
P
L
K
L
Q
Q
T
A
F
E
N
A
Y
L
K
A
Q
E
G
M
R
E
M
S
H
S
A
E
N
1140
1141
P
E
T
L
D
E
I
Y
N
R
K
S
V
L
L
T
L
I
A
V
V
L
S
C
S
P
I
C
E
K
Q
A
L
F
A
L
C
K
S
V
K
E
N
G
L
E
P
H
L
V
K
K
V
L
E
K
V
S
E
T
1200
1201
F
G
Y
R
R
L
E
D
F
M
A
S
H
L
D
Y
L
V
L
E
W
L
N
L
Q
D
T
E
Y
N
L
S
S
F
P
F
I
L
L
N
Y
T
N
I
E
D
F
Y
R
S
C
Y
K
V
L
I
P
H
L
V
1260
1261
I
R
S
H
F
D
E
V
K
S
I
A
N
Q
I
Q
E
D
W
K
S
L
L
T
D
C
F
P
K
I
L
V
N
I
L
P
Y
F
A
Y
E
G
T
R
D
S
G
M
A
Q
Q
R
E
T
A
T
K
V
Y
D
1320
1321
M
L
K
S
E
N
L
L
G
K
Q
I
D
H
L
F
I
S
N
L
P
E
I
V
V
E
L
L
M
T
L
H
E
P
A
N
S
S
A
S
Q
S
T
D
L
C
D
F
S
G
D
L
D
P
A
P
N
P
P
H
1380
1381
F
P
S
H
V
I
K
A
T
F
A
Y
I
S
N
C
H
K
T
K
L
K
S
I
L
E
I
L
S
K
S
P
D
S
Y
Q
K
I
L
L
A
I
C
E
Q
A
A
E
T
N
N
V
Y
K
K
H
R
I
L
K
1440
1441
I
Y
H
L
F
V
S
L
L
L
K
D
I
K
S
G
L
G
G
A
W
A
F
V
L
R
D
V
I
Y
T
L
I
H
Y
I
N
Q
R
P
S
C
I
M
D
V
S
L
R
S
F
S
L
C
C
D
L
L
S
Q
1500
1501
V
C
Q
T
A
V
T
Y
C
K
D
A
L
E
N
H
L
H
V
I
V
G
T
L
I
P
L
V
Y
E
Q
V
E
V
Q
K
Q
V
L
D
L
L
K
Y
L
V
I
D
N
K
D
N
E
N
L
Y
I
T
I
K
1560
1561
L
L
D
P
F
P
D
H
V
V
F
K
D
L
R
I
T
Q
Q
K
I
K
Y
S
R
G
P
F
S
L
L
E
E
I
N
H
F
L
S
V
S
V
Y
D
A
L
P
L
T
R
L
E
G
L
K
D
L
R
R
Q
1620
1621
L
E
L
H
K
D
Q
M
V
D
I
M
R
A
S
Q
D
N
P
Q
D
G
I
M
V
K
L
V
V
N
L
L
Q
L
S
K
M
A
I
N
H
T
G
E
K
E
V
L
E
A
V
G
S
C
L
G
E
V
G
P
1680
1681
I
D
F
S
T
I
A
I
Q
H
S
K
D
A
S
Y
T
K
A
L
K
L
F
E
D
K
E
L
Q
W
T
F
I
M
L
T
Y
L
N
N
T
L
V
E
D
C
V
K
V
R
S
A
A
V
T
C
L
K
N
I
1740
1741
L
A
T
K
T
G
H
S
F
W
E
I
Y
K
M
T
T
D
P
M
L
A
Y
L
Q
P
F
R
T
S
R
K
K
F
L
E
V
P
R
F
D
K
E
N
P
F
E
G
L
D
D
I
N
L
W
I
P
L
S
E
1800
1801
N
H
D
I
W
I
K
T
L
T
C
A
F
L
D
S
G
G
T
K
C
E
I
L
Q
L
L
K
P
M
C
E
V
K
T
D
F
C
Q
T
V
L
P
Y
L
I
H
D
I
L
L
Q
D
T
N
E
S
W
R
N
1860
1861
L
L
S
T
H
V
Q
G
F
F
T
S
C
L
R
H
F
S
Q
T
S
R
S
T
T
P
A
N
L
D
S
E
S
E
H
F
F
R
C
C
L
D
K
K
S
Q
R
T
M
L
A
V
V
D
Y
M
R
R
Q
K
1920
1921
R
P
S
S
G
T
I
F
N
D
A
F
W
L
D
L
N
Y
L
E
V
A
K
V
A
Q
S
C
A
A
H
F
T
A
L
L
Y
A
E
I
Y
A
D
K
K
S
M
D
D
Q
E
K
R
S
L
A
F
E
E
G
1980
1981
S
Q
S
T
T
I
S
S
L
S
E
K
S
K
E
E
T
G
I
S
L
Q
D
L
L
L
E
I
Y
R
S
I
G
E
P
D
S
L
Y
G
C
G
G
G
K
M
L
Q
P
I
T
R
L
R
T
Y
E
H
E
A
2040
2041
M
W
G
K
A
L
V
T
Y
D
L
E
T
A
I
P
S
S
T
R
Q
A
G
I
I
Q
A
L
Q
N
L
G
L
C
H
I
L
S
V
Y
L
K
G
L
D
Y
E
N
K
D
W
C
P
E
L
E
E
L
H
Y
2100
2101
Q
A
A
W
R
N
M
Q
W
D
H
C
T
S
V
S
K
E
V
E
G
T
S
Y
H
E
S
L
Y
N
A
L
Q
S
L
R
D
R
E
F
S
T
F
Y
E
S
L
K
Y
A
R
V
K
E
V
E
E
M
C
K
2160
2161
R
S
L
E
S
V
Y
S
L
Y
P
T
L
S
R
L
Q
A
I
G
E
L
E
S
I
G
E
L
F
S
R
S
V
T
H
R
Q
L
S
E
V
Y
I
K
W
Q
K
H
S
Q
L
L
K
D
S
D
F
S
F
Q
2220
2221
E
P
I
M
A
L
R
T
V
I
L
E
I
L
M
E
K
E
M
D
N
S
Q
R
E
C
I
K
D
I
L
T
K
H
L
V
E
L
S
I
L
A
R
T
F
K
N
T
Q
L
P
E
R
A
I
F
Q
I
K
Q
2280
2281
Y
N
S
V
S
C
G
V
S
E
W
Q
L
E
E
A
Q
V
F
W
A
K
K
E
Q
S
L
A
L
S
I
L
K
Q
M
I
K
K
L
D
A
S
C
A
A
N
N
P
S
L
K
L
T
Y
T
E
C
L
R
V
2340
2341
C
G
N
W
L
A
E
T
C
L
E
N
P
A
V
I
M
Q
T
Y
L
E
K
A
V
E
V
A
G
N
Y
D
G
E
S
S
D
E
L
R
N
G
K
M
K
A
F
L
S
L
A
R
F
S
D
T
Q
Y
Q
R
2400
2401
I
E
N
Y
M
K
S
S
E
F
E
N
K
Q
A
L
L
K
R
A
K
E
E
V
G
L
L
R
E
H
K
I
Q
T
N
R
Y
T
V
K
V
Q
R
E
L
E
L
D
E
L
A
L
R
A
L
K
E
D
R
K
2460
2461
R
F
L
C
K
A
V
E
N
Y
I
N
C
L
L
S
G
E
E
H
D
M
W
V
F
R
L
C
S
L
W
L
E
N
S
G
V
S
E
V
N
G
M
M
K
R
D
G
M
K
I
P
T
Y
K
F
L
P
L
M
2520
2521
Y
Q
L
A
A
R
M
G
T
K
M
M
G
G
L
G
F
H
E
V
L
N
N
L
I
S
R
I
S
M
D
H
P
H
H
T
L
F
I
I
L
A
L
A
N
A
N
R
D
E
F
L
T
K
P
E
V
A
R
R
2580
2581
S
R
I
T
K
N
V
P
K
Q
S
S
Q
L
D
E
D
R
T
E
A
A
N
R
I
I
C
T
I
R
S
R
R
P
Q
M
V
R
S
V
E
A
L
C
D
A
Y
I
I
L
A
N
L
D
A
T
Q
W
K
T
2640
2641
Q
R
K
G
I
N
I
P
A
D
Q
P
I
T
K
L
K
N
L
E
D
V
V
V
P
T
M
E
I
K
V
D
H
T
G
E
Y
G
N
L
V
T
I
Q
S
F
K
A
E
F
R
L
A
G
G
V
N
L
P
K
2700
2701
I
I
D
C
V
G
S
D
G
K
E
R
R
Q
L
V
K
G
R
D
D
L
R
Q
D
A
V
M
Q
Q
V
F
Q
M
C
N
T
L
L
Q
R
N
T
E
T
R
K
R
K
L
T
I
C
T
Y
K
V
V
P
L
2760
2761
S
Q
R
S
G
V
L
E
W
C
T
G
T
V
P
I
G
E
F
L
V
N
N
E
D
G
A
H
K
R
Y
R
P
N
D
F
S
A
F
Q
C
Q
K
K
M
M
E
V
Q
K
K
S
F
E
E
K
Y
E
V
F
2820
2821
M
D
V
C
Q
N
F
Q
P
V
F
R
Y
F
C
M
E
K
F
L
D
P
A
I
W
F
E
K
R
L
A
Y
T
R
S
V
A
T
S
S
I
V
G
Y
I
L
G
L
G
D
R
H
V
Q
N
I
L
I
N
E
2880
2881
Q
S
A
E
L
V
H
I
D
L
G
V
A
F
E
Q
G
K
I
L
P
T
P
E
T
V
P
F
R
L
T
R
D
I
V
D
G
M
G
I
T
G
V
E
G
V
F
R
R
C
C
E
K
T
M
E
V
M
R
N
2940
2941
S
Q
E
T
L
L
T
I
V
E
V
L
L
Y
D
P
L
F
D
W
T
M
N
P
L
K
A
L
Y
L
Q
Q
R
P
E
D
E
T
E
L
H
P
T
L
N
A
D
D
Q
E
C
K
R
N
L
S
D
I
D
Q
3000
3001
S
F
N
K
V
A
E
R
V
L
M
R
L
Q
E
K
L
K
G
V
E
E
G
T
V
L
S
V
G
G
Q
V
N
L
L
I
Q
Q
A
I
D
P
K
N
L
S
R
L
F
P
G
W
K
A
W
V
3056
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0498
Peptide:
KYLNWD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13315
UniProt Name:
ATM_HUMAN
Protein Name:
Serine-protein kinase ATM
Position:
53-58
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-0.26
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-14.9
Area of the profile Above Threshold (AGGRESCAN):
0.4
Best Energy Score (PASTA 2.0):
-2.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0499 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
P
G
Q
I
I
S
I
P
F
L
S
Q
N
E
D
M
D
K
Y
L
L
E
Y
R
S
L
K
L
L
H
Q
S
S
N
S
F
Q
S
H
N
A
P
S
H
Q
S
N
Y
H
P
H
Y
N
H
M
K
Y
N
N
60
61
T
G
S
Y
Y
Y
Y
N
N
N
N
N
S
S
V
N
P
H
N
Q
A
G
L
Q
S
I
N
R
S
I
P
S
A
P
Y
G
A
Y
N
Q
N
R
A
N
D
V
P
Y
M
N
T
Q
K
K
H
H
R
F
S
A
120
121
N
N
N
L
N
Q
Q
K
Y
K
Q
Y
P
Q
Y
T
S
N
P
M
V
T
A
H
L
K
Q
T
Y
P
Q
L
Y
Y
N
S
N
V
N
A
H
N
N
N
N
N
S
N
N
N
N
N
N
N
N
N
S
N
N
N
180
181
N
N
L
Y
N
Q
T
Q
F
S
T
R
Y
F
N
S
N
S
S
P
S
L
T
S
S
T
S
N
S
S
S
P
Y
N
Q
S
T
F
E
Y
I
L
P
S
T
S
A
A
S
T
N
L
S
S
S
S
S
N
N
S
240
241
M
H
T
N
P
T
T
A
T
S
T
S
A
D
L
I
N
D
L
P
V
G
P
T
S
S
S
L
I
S
D
L
H
S
P
P
T
V
S
F
L
P
A
S
Q
T
L
L
M
S
S
T
T
S
S
S
I
G
T
N
300
301
I
N
P
P
Q
H
S
P
S
P
S
Q
R
E
D
F
S
T
A
P
V
N
M
S
S
S
A
S
L
L
M
N
D
S
S
L
G
W
G
S
N
H
M
N
V
S
S
S
S
Q
P
A
S
S
R
P
F
G
I
W
360
361
N
T
D
M
S
V
W
S
368
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0499
Peptide:
KYNNTG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P38180
UniProt Name:
YBI1_YEAST
Protein Name:
Uncharacterized protein YBL081W
Position:
57-62
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-71.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.47
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0500 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0500
Peptide:
LAAVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40A
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
0.91
Tango:
6.49
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
57.8
Area of the profile Above Threshold (AGGRESCAN):
3.73
Best Energy Score (PASTA 2.0):
-4.2
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0501 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0501
Peptide:
LACVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40C
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.08
Tango:
1.76
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
70.6
Area of the profile Above Threshold (AGGRESCAN):
4.56
Best Energy Score (PASTA 2.0):
-4.77
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0502 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0502
Peptide:
LADVYV
Length:
6
Classification:
non-amyloid
Mutation(s):
T40D
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
21.8
Area of the profile Above Threshold (AGGRESCAN):
1.6
Best Energy Score (PASTA 2.0):
-3.21
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0503 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0503
Peptide:
LAEAIG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.06
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-14.8
Area of the profile Above Threshold (AGGRESCAN):
0.36
Best Energy Score (PASTA 2.0):
0.75
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0504 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0504
Peptide:
LAEVYV
Length:
6
Classification:
non-amyloid
Mutation(s):
T40E
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.85
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
30.3
Area of the profile Above Threshold (AGGRESCAN):
1.94
Best Energy Score (PASTA 2.0):
-2.08
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0505 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0505
Peptide:
LAFVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40F
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.01
Tango:
86.77
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
93.6
Area of the profile Above Threshold (AGGRESCAN):
6.05
Best Energy Score (PASTA 2.0):
-5.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0506 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0506
Peptide:
LAGVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40G
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.83
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
47.8
Area of the profile Above Threshold (AGGRESCAN):
3.08
Best Energy Score (PASTA 2.0):
-3.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0507 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0507
Peptide:
LAHVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40H
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.91
Tango:
1.04
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
37.9
Area of the profile Above Threshold (AGGRESCAN):
2.43
Best Energy Score (PASTA 2.0):
-4.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0508 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0508
Peptide:
LAIVYV
Length:
6
Classification:
amyloid
Mutation(s):
T40I
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.06
Tango:
78.36
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
95.0
Area of the profile Above Threshold (AGGRESCAN):
6.14
Best Energy Score (PASTA 2.0):
-6.67
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0509 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0509
Peptide:
LAKVYV
Length:
6
Classification:
non-amyloid
Mutation(s):
T40K
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
39.9
Area of the profile Above Threshold (AGGRESCAN):
2.56
Best Energy Score (PASTA 2.0):
-3.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0510 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0510
Peptide:
LALQTD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
57-62
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-22.2
Area of the profile Above Threshold (AGGRESCAN):
0.29
Best Energy Score (PASTA 2.0):
0.34
Aggregate Orientation (PASTA 2.0):
Parallel
