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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 331 to 360 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0331
GVIWIA
6
Amyloid
Superoxide dismutase (hSod1)
P00441
G151W
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0332
GVNNNN
6
Non-amyloid
Transcriptional regulator URE2
P23202
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0333
GVNYFL
6
Amyloid
Cystatin-C
P01034
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0334
GVPGIA
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
I150P
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0335
GVQVGD
6
amyloid
Receptor-interacting serine/threonine-protein kinase 3
Q9Y572
No
Cell. 2012 Jul 20;150(2):339-50.
22817896
Waltz-DB 2.0
P-0336
GVTIIT
6
Non-amyloid
Cell wall adhesin EAP1
G1UBC2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0337
GVVPQY
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0338
GVVTSE
6
amyloid
No
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2220-E2228.
29476011
Waltz-DB 2.0
P-0339
GVVVVT
6
Non-amyloid
Caf1 hyphal wall protein 1
B2L5Z5
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0340
GVWWFF
6
Amyloid
Integrin beta-1 (Fibronectin receptor subunit beta)
P05556
Nat Methods. 2010 Mar;7(3):237-42., BMC Bioinformatics. 2013;14 Suppl 8:S6.
20154676
CPAD, Waltz-DB 2.0
P-0341
GWGSAS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0342
GYCFIL
6
Amyloid
Gelsolin (AGEL)
P06396
D214Y
Prion. 2007 Jan-Mar;1(1):9-14.
19164912
CPAD, Waltz-DB 2.0
P-0343
GYFILQ
6
Amyloid
Gamma-aminobutyric acid receptor subunit beta-1
P18505
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0344
GYFLNF
6
Amyloid
Tyrosine-protein kinase transmembrane receptor ROR2
Q01974
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0345
GYFLNM
6
Amyloid
G-protein coupled receptor 20
Q99678
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0346
GYGQSS
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0347
GYMLGS
6
Amyloid
Major prion protein (PrP)
P04156
No
J Biol Chem. 2010 Sep 24;285(39):29671-5.
20685658
Waltz-DB 2.0, AmyLoad
P-0348
GYQAGF
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0349
GYQAYN
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0350
GYQQGG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0351
GYQQQF
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0352
GYQQQY
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0353
GYQQYN
6
Non-amyloid
Waltz-DB 2.0
P-0354
GYSGYQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0355
GYVIIK
6
amyloid
Serum amyloid P-component
P02743
No
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
23552370
Waltz-DB 2.0
P-0356
GYVLGS
6
Amyloid
No
J Biol Chem. 2010 Sep 24;285(39):29671-5.
20685658
Waltz-DB 2.0, AmyLoad
P-0357
GYYQNY
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0358
HAFLII
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0359
HATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38H
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0360
HFVWIA
6
Amyloid
Cystic fibrosis transmembrane conductance regulator (CFTR)
P13569
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
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Entry: P-0331 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0331
Peptide:
GVIWIA
Length:
6
Classification:
Amyloid
Mutation(s):
G151W
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
148-153
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.03
Tango:
1.58
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
79.0
Area of the profile Above Threshold (AGGRESCAN):
5.1
Best Energy Score (PASTA 2.0):
-6.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0332 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0332
Peptide:
GVNNNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
42-47
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-84.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.94
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0333 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
P
L
R
A
P
L
L
L
L
A
I
L
A
V
A
L
A
V
S
P
A
A
G
S
S
P
G
K
P
P
R
L
V
G
G
P
M
D
A
S
V
E
E
E
G
V
R
R
A
L
D
F
A
V
G
E
Y
60
61
N
K
A
S
N
D
M
Y
H
S
R
A
L
Q
V
V
R
A
R
K
Q
I
V
A
G
V
N
Y
F
L
D
V
E
L
G
R
T
T
C
T
K
T
Q
P
N
L
D
N
C
P
F
H
D
Q
P
H
L
K
R
K
120
121
A
F
C
S
F
Q
I
Y
A
V
P
W
Q
G
T
M
T
L
S
K
S
T
C
Q
D
A
146
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0333
Peptide:
GVNYFL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01034
UniProt Name:
CYTC_HUMAN
Protein Name:
Cystatin-C
Position:
85-90
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.71
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
32.2
Area of the profile Above Threshold (AGGRESCAN):
2.29
Best Energy Score (PASTA 2.0):
-4.06
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0334 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0334
Peptide:
GVPGIA
Length:
6
Classification:
Non-amyloid
Mutation(s):
I150P
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
148-153
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.28
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
4.4
Area of the profile Above Threshold (AGGRESCAN):
0.52
Best Energy Score (PASTA 2.0):
1.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0335 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
S
C
V
K
L
W
P
S
G
A
P
A
P
L
V
S
I
E
E
L
E
N
Q
E
L
V
G
K
G
G
F
G
T
V
F
R
A
Q
H
R
K
W
G
Y
D
V
A
V
K
I
V
N
S
K
A
I
S
R
E
60
61
V
K
A
M
A
S
L
D
N
E
F
V
L
R
L
E
G
V
I
E
K
V
N
W
D
Q
D
P
K
P
A
L
V
T
K
F
M
E
N
G
S
L
S
G
L
L
Q
S
Q
C
P
R
P
W
P
L
L
C
R
L
120
121
L
K
E
V
V
L
G
M
F
Y
L
H
D
Q
N
P
V
L
L
H
R
D
L
K
P
S
N
V
L
L
D
P
E
L
H
V
K
L
A
D
F
G
L
S
T
F
Q
G
G
S
Q
S
G
T
G
S
G
E
P
G
180
181
G
T
L
G
Y
L
A
P
E
L
F
V
N
V
N
R
K
A
S
T
A
S
D
V
Y
S
F
G
I
L
M
W
A
V
L
A
G
R
E
V
E
L
P
T
E
P
S
L
V
Y
E
A
V
C
N
R
Q
N
R
P
240
241
S
L
A
E
L
P
Q
A
G
P
E
T
P
G
L
E
G
L
K
E
L
M
Q
L
C
W
S
S
E
P
K
D
R
P
S
F
Q
E
C
L
P
K
T
D
E
V
F
Q
M
V
E
N
N
M
N
A
A
V
S
T
300
301
V
K
D
F
L
S
Q
L
R
S
S
N
R
R
F
S
I
P
E
S
G
Q
G
G
T
E
M
D
G
F
R
R
T
I
E
N
Q
H
S
R
N
D
V
M
V
S
E
W
L
N
K
L
N
L
E
E
P
P
S
S
360
361
V
P
K
K
C
P
S
L
T
K
R
S
R
A
Q
E
E
Q
V
P
Q
A
W
T
A
G
T
S
S
D
S
M
A
Q
P
P
Q
T
P
E
T
S
T
F
R
N
Q
M
P
S
P
T
S
T
G
T
P
S
P
G
420
421
P
R
G
N
Q
G
A
E
R
Q
G
M
N
W
S
C
R
T
P
E
P
N
P
V
T
G
R
P
L
V
N
I
Y
N
C
S
G
V
Q
V
G
D
N
N
Y
L
T
M
Q
Q
T
T
A
L
P
T
W
G
L
A
480
481
P
S
G
K
G
R
G
L
Q
H
P
P
P
V
G
S
Q
E
G
P
K
D
P
E
A
W
S
R
P
Q
G
W
Y
N
H
S
G
K
518
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0335
Peptide:
GVQVGD
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q9Y572
UniProt Name:
RIPK3_HUMAN
Protein Name:
Receptor-interacting serine/threonine-protein kinase 3
Position:
457-462
Literature
PMID:
22817896
Reference:
Cell. 2012 Jul 20;150(2):339-50.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.4
Area of the profile Above Threshold (AGGRESCAN):
0.2
Best Energy Score (PASTA 2.0):
-1.24
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0336 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
S
Q
I
L
P
L
A
G
A
I
S
V
A
S
G
F
W
I
P
D
F
S
N
K
Q
N
S
N
S
Y
P
G
Q
Y
K
G
K
G
G
Y
Q
D
D
C
G
D
D
Y
K
K
G
Y
K
S
K
T
Y
60
61
S
K
V
K
P
I
T
S
T
D
C
T
T
P
I
Q
P
T
G
T
T
T
G
Y
T
K
D
V
V
E
S
T
S
Y
T
T
D
T
A
Y
T
T
T
V
I
T
V
T
K
C
D
G
G
S
C
S
H
T
A
V
120
121
T
T
G
V
T
I
I
T
V
T
T
N
D
V
I
T
E
Y
T
T
Y
C
P
L
T
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
180
181
E
S
T
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
240
241
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
A
S
T
E
T
A
S
S
T
P
V
E
S
T
V
I
V
P
S
T
T
V
I
T
V
S
S
C
Y
E
D
K
C
S
V
S
S
V
T
T
G
V
V
T
I
300
301
S
S
E
E
T
I
Y
T
T
Y
C
P
I
T
S
S
I
T
I
P
V
P
N
T
S
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
360
361
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
420
421
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
A
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
480
481
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
S
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
G
T
E
A
T
P
V
T
T
Q
P
540
541
V
S
V
L
S
T
S
Q
V
V
T
A
S
G
E
F
S
T
V
T
A
H
S
T
S
I
V
A
S
C
P
E
G
G
C
V
P
E
G
Q
Q
T
E
T
S
P
S
V
P
T
N
G
P
E
V
E
A
S
S
S
600
601
V
L
S
I
P
V
S
S
V
T
T
S
T
I
A
S
S
S
E
T
S
V
P
P
A
Q
V
S
T
F
E
G
S
G
S
A
L
K
K
P
Y
Y
G
L
A
V
A
A
L
V
Y
F
M
653
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0336
Peptide:
GVTIIT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
G1UBC2
UniProt Name:
G1UBC2_CANAL
Protein Name:
Cell wall adhesin EAP1
Position:
123-128
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.77
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
53.8
Area of the profile Above Threshold (AGGRESCAN):
3.47
Best Energy Score (PASTA 2.0):
-6.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0337 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0337
Peptide:
GVVPQY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
21-26
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
18.2
Area of the profile Above Threshold (AGGRESCAN):
0.72
Best Energy Score (PASTA 2.0):
0.85
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0338 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
G
V
V
T
S
E
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0338
Peptide:
GVVTSE
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
29476011
Reference:
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2220-E2228.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.5
Area of the profile Above Threshold (AGGRESCAN):
1.23
Best Energy Score (PASTA 2.0):
-3.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0339 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
L
S
T
A
Q
L
I
A
I
A
Y
Y
M
L
S
I
G
A
T
V
P
Q
V
D
G
Q
G
E
T
E
E
A
L
I
Q
K
R
S
Y
D
Y
Y
Q
E
P
C
D
D
Y
P
Q
Q
Q
Q
Q
E
E
P
60
61
C
D
Y
P
Q
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
120
121
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
Q
P
D
D
N
P
P
I
P
N
I
P
T
D
W
I
P
N
I
P
T
D
W
I
P
D
I
P
E
K
P
180
181
T
T
P
A
T
T
P
N
I
P
A
T
T
T
T
S
E
S
S
S
S
S
S
S
S
S
S
T
T
P
K
T
S
A
S
T
T
P
E
S
S
V
P
A
T
T
P
N
T
S
V
P
T
T
S
S
E
S
T
T
240
241
P
A
T
S
P
E
S
S
V
P
V
T
S
G
S
S
I
L
A
T
T
S
E
S
S
S
A
P
A
T
T
P
N
T
S
V
P
T
T
T
T
E
T
K
S
S
S
T
P
L
T
T
T
T
E
H
D
T
T
V
300
301
V
T
V
T
S
C
S
N
S
V
C
T
E
S
E
V
T
T
G
V
I
V
I
T
S
K
D
T
I
Y
T
T
Y
C
P
L
T
E
T
T
P
V
S
T
A
P
A
T
E
T
P
T
G
T
V
S
T
S
T
E
360
361
Q
S
T
T
V
I
T
V
T
S
C
S
E
S
S
C
T
E
S
E
V
T
T
G
V
V
V
V
T
S
E
E
T
V
Y
T
T
F
C
P
L
T
E
N
T
P
G
T
D
S
T
P
E
A
S
I
P
P
M
E
420
421
T
I
P
A
G
S
E
P
S
M
P
A
G
E
T
S
P
A
V
P
K
S
D
V
P
A
T
E
S
A
P
A
P
G
M
T
P
A
G
T
E
T
K
P
A
A
P
K
S
S
A
P
A
T
E
P
S
P
V
A
480
481
P
G
T
E
S
A
P
A
G
S
S
G
A
I
T
I
P
E
S
S
A
V
V
S
T
T
E
G
A
I
P
T
T
L
E
S
V
P
L
M
Q
P
S
A
N
Y
S
S
V
A
P
I
S
T
F
E
G
A
G
N
540
541
N
M
R
L
T
F
G
A
A
I
I
G
I
A
A
F
L
I
558
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0339
Peptide:
GVVVVT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B2L5Z5
UniProt Name:
B2L5Z5_9ASCO
Protein Name:
Caf1 hyphal wall protein 1
Position:
384-389
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.96
Tango:
4.23
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
81.3
Area of the profile Above Threshold (AGGRESCAN):
5.27
Best Energy Score (PASTA 2.0):
-8.1
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0340 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0340
Peptide:
GVWWFF
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P05556
UniProt Name:
ITB1_HUMAN
Protein Name:
Integrin beta-1 (Fibronectin receptor subunit beta)
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42., BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.94
Tango:
9.99
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
80.3
Area of the profile Above Threshold (AGGRESCAN):
5.1
Best Energy Score (PASTA 2.0):
-5.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0341 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0341
Peptide:
GWGSAS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
384-389
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-29.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.6
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0342 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0342
Peptide:
GYCFIL
Length:
6
Classification:
Amyloid
Mutation(s):
D214Y
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
213-218
Literature
PMID:
19164912
Reference:
Prion. 2007 Jan-Mar;1(1):9-14.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
77.3
Area of the profile Above Threshold (AGGRESCAN):
4.9
Best Energy Score (PASTA 2.0):
-4.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0343 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
W
T
V
Q
N
R
E
S
L
G
L
L
S
F
P
V
M
I
T
M
V
C
C
A
H
S
T
N
E
P
S
N
M
S
Y
V
K
E
T
V
D
R
L
L
K
G
Y
D
I
R
L
R
P
D
F
G
G
P
P
60
61
V
D
V
G
M
R
I
D
V
A
S
I
D
M
V
S
E
V
N
M
D
Y
T
L
T
M
Y
F
Q
Q
S
W
K
D
K
R
L
S
Y
S
G
I
P
L
N
L
T
L
D
N
R
V
A
D
Q
L
W
V
P
D
120
121
T
Y
F
L
N
D
K
K
S
F
V
H
G
V
T
V
K
N
R
M
I
R
L
H
P
D
G
T
V
L
Y
G
L
R
I
T
T
T
A
A
C
M
M
D
L
R
R
Y
P
L
D
E
Q
N
C
T
L
E
I
E
180
181
S
Y
G
Y
T
T
D
D
I
E
F
Y
W
N
G
G
E
G
A
V
T
G
V
N
K
I
E
L
P
Q
F
S
I
V
D
Y
K
M
V
S
K
K
V
E
F
T
T
G
A
Y
P
R
L
S
L
S
F
R
L
K
240
241
R
N
I
G
Y
F
I
L
Q
T
Y
M
P
S
T
L
I
T
I
L
S
W
V
S
F
W
I
N
Y
D
A
S
A
A
R
V
A
L
G
I
T
T
V
L
T
M
T
T
I
S
T
H
L
R
E
T
L
P
K
I
300
301
P
Y
V
K
A
I
D
I
Y
L
M
G
C
F
V
F
V
F
L
A
L
L
E
Y
A
F
V
N
Y
I
F
F
G
K
G
P
Q
K
K
G
A
S
K
Q
D
Q
S
A
N
E
K
N
K
L
E
M
N
K
V
Q
360
361
V
D
A
H
G
N
I
L
L
S
T
L
E
I
R
N
E
T
S
G
S
E
V
L
T
S
V
S
D
P
K
A
T
M
Y
S
Y
D
S
A
S
I
Q
Y
R
K
P
L
S
S
R
E
A
Y
G
R
A
L
D
R
420
421
H
G
V
P
S
K
G
R
I
R
R
R
A
S
Q
L
K
V
K
I
P
D
L
T
D
V
N
S
I
D
K
W
S
R
M
F
F
P
I
T
F
S
L
F
N
V
V
Y
W
L
Y
Y
V
H
474
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0343
Peptide:
GYFILQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P18505
UniProt Name:
GBRB1_HUMAN
Protein Name:
Gamma-aminobutyric acid receptor subunit beta-1
Position:
244-249
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.83
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
69.7
Area of the profile Above Threshold (AGGRESCAN):
4.57
Best Energy Score (PASTA 2.0):
-4.05
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0344 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
R
G
S
A
L
P
R
R
P
L
L
C
I
P
A
V
W
A
A
A
A
L
L
L
S
V
S
R
T
S
G
E
V
E
V
L
D
P
N
D
P
L
G
P
L
D
G
Q
D
G
P
I
P
T
L
K
G
Y
60
61
F
L
N
F
L
E
P
V
N
N
I
T
I
V
Q
G
Q
T
A
I
L
H
C
K
V
A
G
N
P
P
P
N
V
R
W
L
K
N
D
A
P
V
V
Q
E
P
R
R
I
I
I
R
K
T
E
Y
G
S
R
L
120
121
R
I
Q
D
L
D
T
T
D
T
G
Y
Y
Q
C
V
A
T
N
G
M
K
T
I
T
A
T
G
V
L
F
V
R
L
G
P
T
H
S
P
N
H
N
F
Q
D
D
Y
H
E
D
G
F
C
Q
P
Y
R
G
I
180
181
A
C
A
R
F
I
G
N
R
T
I
Y
V
D
S
L
Q
M
Q
G
E
I
E
N
R
I
T
A
A
F
T
M
I
G
T
S
T
H
L
S
D
Q
C
S
Q
F
A
I
P
S
F
C
H
F
V
F
P
L
C
D
240
241
A
R
S
R
T
P
K
P
R
E
L
C
R
D
E
C
E
V
L
E
S
D
L
C
R
Q
E
Y
T
I
A
R
S
N
P
L
I
L
M
R
L
Q
L
P
K
C
E
A
L
P
M
P
E
S
P
D
A
A
N
C
300
301
M
R
I
G
I
P
A
E
R
L
G
R
Y
H
Q
C
Y
N
G
S
G
M
D
Y
R
G
T
A
S
T
T
K
S
G
H
Q
C
Q
P
W
A
L
Q
H
P
H
S
H
H
L
S
S
T
D
F
P
E
L
G
G
360
361
G
H
A
Y
C
R
N
P
G
G
Q
M
E
G
P
W
C
F
T
Q
N
K
N
V
R
M
E
L
C
D
V
P
S
C
S
P
R
D
S
S
K
M
G
I
L
Y
I
L
V
P
S
I
A
I
P
L
V
I
A
C
420
421
L
F
F
L
V
C
M
C
R
N
K
Q
K
A
S
A
S
T
P
Q
R
R
Q
L
M
A
S
P
S
Q
D
M
E
M
P
L
I
N
Q
H
K
Q
A
K
L
K
E
I
S
L
S
A
V
R
F
M
E
E
L
G
480
481
E
D
R
F
G
K
V
Y
K
G
H
L
F
G
P
A
P
G
E
Q
T
Q
A
V
A
I
K
T
L
K
D
K
A
E
G
P
L
R
E
E
F
R
H
E
A
M
L
R
A
R
L
Q
H
P
N
V
V
C
L
L
540
541
G
V
V
T
K
D
Q
P
L
S
M
I
F
S
Y
C
S
H
G
D
L
H
E
F
L
V
M
R
S
P
H
S
D
V
G
S
T
D
D
D
R
T
V
K
S
A
L
E
P
P
D
F
V
H
L
V
A
Q
I
A
600
601
A
G
M
E
Y
L
S
S
H
H
V
V
H
K
D
L
A
T
R
N
V
L
V
Y
D
K
L
N
V
K
I
S
D
L
G
L
F
R
E
V
Y
A
A
D
Y
Y
K
L
L
G
N
S
L
L
P
I
R
W
M
A
660
661
P
E
A
I
M
Y
G
K
F
S
I
D
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
Y
G
L
Q
P
Y
C
G
Y
S
N
Q
D
V
V
E
M
I
R
N
R
Q
V
L
P
C
P
D
D
C
P
A
W
720
721
V
Y
A
L
M
I
E
C
W
N
E
F
P
S
R
R
P
R
F
K
D
I
H
S
R
L
R
A
W
G
N
L
S
N
Y
N
S
S
A
Q
T
S
G
A
S
N
T
T
Q
T
S
S
L
S
T
S
P
V
S
N
780
781
V
S
N
A
R
Y
V
G
P
K
Q
K
A
P
P
F
P
Q
P
Q
F
I
P
M
K
G
Q
I
R
P
M
V
P
P
P
Q
L
Y
V
P
V
N
G
Y
Q
P
V
P
A
Y
G
A
Y
L
P
N
F
Y
P
V
840
841
Q
I
P
M
Q
M
A
P
Q
Q
V
P
P
Q
M
V
P
K
P
S
S
H
H
S
G
S
G
S
T
S
T
G
Y
V
T
T
A
P
S
N
T
S
M
A
D
R
A
A
L
L
S
E
G
A
D
D
T
Q
N
A
900
901
P
E
D
G
A
Q
S
T
V
Q
E
A
E
E
E
E
E
G
S
V
P
E
T
E
L
L
G
D
C
D
T
L
Q
V
D
E
A
Q
V
Q
L
E
A
943
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0344
Peptide:
GYFLNF
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q01974
UniProt Name:
ROR2_HUMAN
Protein Name:
Tyrosine-protein kinase transmembrane receptor ROR2
Position:
59-64
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.69
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
54.9
Area of the profile Above Threshold (AGGRESCAN):
3.64
Best Energy Score (PASTA 2.0):
-2.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0345 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
P
S
V
S
P
A
G
P
S
A
G
A
V
P
N
A
T
A
V
T
T
V
R
T
N
A
S
G
L
E
V
P
L
F
H
L
F
A
R
L
D
E
E
L
H
G
T
F
P
G
L
W
L
A
L
M
A
V
H
60
61
G
A
I
F
L
A
G
L
V
L
N
G
L
A
L
Y
V
F
C
C
R
T
R
A
K
T
P
S
V
I
Y
T
I
N
L
V
V
T
D
L
L
V
G
L
S
L
P
T
R
F
A
V
Y
Y
G
A
R
G
C
L
120
121
R
C
A
F
P
H
V
L
G
Y
F
L
N
M
H
C
S
I
L
F
L
T
C
I
C
V
D
R
Y
L
A
I
V
R
P
E
G
S
R
R
C
R
Q
P
A
C
A
R
A
V
C
A
F
V
W
L
A
A
G
A
180
181
V
T
L
S
V
L
G
V
T
G
S
R
P
C
C
R
V
F
A
L
T
V
L
E
F
L
L
P
L
L
V
I
S
V
F
T
G
R
I
M
C
A
L
S
R
P
G
L
L
H
Q
G
R
Q
R
R
V
R
A
M
240
241
Q
L
L
L
T
V
L
I
I
F
L
V
C
F
T
P
F
H
A
R
Q
V
A
V
A
L
W
P
D
M
P
H
H
T
S
L
V
V
Y
H
V
A
V
T
L
S
S
L
N
S
C
M
D
P
I
V
Y
C
F
V
300
301
T
S
G
F
Q
A
T
V
R
G
L
F
G
Q
H
G
E
R
E
P
S
S
G
D
V
V
S
M
H
R
S
S
K
G
S
G
R
H
H
I
L
S
A
G
P
H
A
L
T
Q
A
L
A
N
G
P
E
A
358
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0345
Peptide:
GYFLNM
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q99678
UniProt Name:
GPR20_HUMAN
Protein Name:
G-protein coupled receptor 20
Position:
129-134
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.33
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.5
Area of the profile Above Threshold (AGGRESCAN):
3.13
Best Energy Score (PASTA 2.0):
-2.24
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0346 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0346
Peptide:
GYGQSS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
49-54
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-50.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.8
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0347 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0347
Peptide:
GYMLGS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
3NHC
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
127-132
Literature
PMID:
20685658
Reference:
J Biol Chem. 2010 Sep 24;285(39):29671-5.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.38
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.8
Area of the profile Above Threshold (AGGRESCAN):
1.92
Best Energy Score (PASTA 2.0):
-0.27
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0348 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0348
Peptide:
GYQAGF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
112-117
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-22.9
Area of the profile Above Threshold (AGGRESCAN):
0.24
Best Energy Score (PASTA 2.0):
0.81
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0349 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0349
Peptide:
GYQAYN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
31-36
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.9
Area of the profile Above Threshold (AGGRESCAN):
0.12
Best Energy Score (PASTA 2.0):
0.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0350 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0350
Peptide:
GYQQGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
54-59
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-69.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.78
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0351 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0351
Peptide:
GYQQQF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
87-92
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-56.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.81
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0352 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0352
Peptide:
GYQQQY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
68-73
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.09
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-62.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.82
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0353 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0353
Peptide:
GYQQYN
Length:
6
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.09
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0354 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0354
Peptide:
GYSGYQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
51-56
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-21.4
Area of the profile Above Threshold (AGGRESCAN):
0.28
Best Energy Score (PASTA 2.0):
0.04
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0355 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
N
K
P
L
L
W
I
S
V
L
T
S
L
L
E
A
F
A
H
T
D
L
S
G
K
V
F
V
F
P
R
E
S
V
T
D
H
V
N
L
I
T
P
L
E
K
P
L
Q
N
F
T
L
C
F
R
A
Y
S
60
61
D
L
S
R
A
Y
S
L
F
S
Y
N
T
Q
G
R
D
N
E
L
L
V
Y
K
E
R
V
G
E
Y
S
L
Y
I
G
R
H
K
V
T
S
K
V
I
E
K
F
P
A
P
V
H
I
C
V
S
W
E
S
S
120
121
S
G
I
A
E
F
W
I
N
G
T
P
L
V
K
K
G
L
R
Q
G
Y
F
V
E
A
Q
P
K
I
V
L
G
Q
E
Q
D
S
Y
G
G
K
F
D
R
S
Q
S
F
V
G
E
I
G
D
L
Y
M
W
D
180
181
S
V
L
P
P
E
N
I
L
S
A
Y
Q
G
T
P
L
P
A
N
I
L
D
W
Q
A
L
N
Y
E
I
R
G
Y
V
I
I
K
P
L
V
W
V
223
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0355
Peptide:
GYVIIK
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02743
UniProt Name:
SAMP_HUMAN
Protein Name:
Serum amyloid P-component
Position:
213-218
Literature
PMID:
23552370
Reference:
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.67
Tango:
21.37
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
75.3
Area of the profile Above Threshold (AGGRESCAN):
4.89
Best Energy Score (PASTA 2.0):
-6.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0356 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0356
Peptide:
GYVLGS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
3NHD
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20685658
Reference:
J Biol Chem. 2010 Sep 24;285(39):29671-5.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
41.4
Area of the profile Above Threshold (AGGRESCAN):
2.81
Best Energy Score (PASTA 2.0):
-1.86
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0357 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0357
Peptide:
GYYQNY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
44-49
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.2
Area of the profile Above Threshold (AGGRESCAN):
0.21
Best Energy Score (PASTA 2.0):
-0.74
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0358 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0358
Peptide:
HAFLII
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
76.3
Area of the profile Above Threshold (AGGRESCAN):
4.75
Best Energy Score (PASTA 2.0):
-5.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0359 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0359
Peptide:
HATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38H
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.33
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
31.2
Area of the profile Above Threshold (AGGRESCAN):
2.46
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0360 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
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L
E
K
A
S
V
V
S
K
L
F
F
S
W
T
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I
L
R
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G
Y
R
Q
R
L
E
L
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D
I
Y
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I
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S
V
D
S
A
D
N
L
S
E
K
L
E
R
E
W
D
R
E
60
61
L
A
S
K
K
N
P
K
L
I
N
A
L
R
R
C
F
F
W
R
F
M
F
Y
G
I
F
L
Y
L
G
E
V
T
K
A
V
Q
P
L
L
L
G
R
I
I
A
S
Y
D
P
D
N
K
E
E
R
S
I
A
120
121
I
Y
L
G
I
G
L
C
L
L
F
I
V
R
T
L
L
L
H
P
A
I
F
G
L
H
H
I
G
M
Q
M
R
I
A
M
F
S
L
I
Y
K
K
T
L
K
L
S
S
R
V
L
D
K
I
S
I
G
Q
L
180
181
V
S
L
L
S
N
N
L
N
K
F
D
E
G
L
A
L
A
H
F
V
W
I
A
P
L
Q
V
A
L
L
M
G
L
I
W
E
L
L
Q
A
S
A
F
C
G
L
G
F
L
I
V
L
A
L
F
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A
G
L
240
241
G
R
M
M
M
K
Y
R
D
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R
A
G
K
I
S
E
R
L
V
I
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E
M
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N
I
Q
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V
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A
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C
W
E
E
A
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E
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M
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N
L
R
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T
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L
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L
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A
A
300
301
Y
V
R
Y
F
N
S
S
A
F
F
F
S
G
F
F
V
V
F
L
S
V
L
P
Y
A
L
I
K
G
I
I
L
R
K
I
F
T
T
I
S
F
C
I
V
L
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M
A
V
T
R
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F
P
W
A
V
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T
360
361
W
Y
D
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L
G
A
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N
K
I
Q
D
F
L
Q
K
Q
E
Y
K
T
L
E
Y
N
L
T
T
T
E
V
V
M
E
N
V
T
A
F
W
E
E
G
F
G
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L
F
E
K
A
K
Q
N
N
N
N
R
K
420
421
T
S
N
G
D
D
S
L
F
F
S
N
F
S
L
L
G
T
P
V
L
K
D
I
N
F
K
I
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R
G
Q
L
L
A
V
A
G
S
T
G
A
G
K
T
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L
L
M
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I
M
G
E
L
E
P
S
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G
480
481
K
I
K
H
S
G
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I
S
F
C
S
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F
S
W
I
M
P
G
T
I
K
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N
I
I
F
G
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Y
D
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Y
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Y
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A
C
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L
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I
V
540
541
L
G
E
G
G
I
T
L
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G
G
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A
R
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L
A
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A
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Y
K
D
A
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L
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L
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L
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K
E
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C
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A
N
K
T
R
600
601
I
L
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L
K
K
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D
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L
I
L
H
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L
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N
S
660
661
I
L
T
E
T
L
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S
L
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G
D
A
P
V
S
W
T
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T
K
K
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F
K
Q
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G
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F
G
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K
R
K
N
S
I
L
N
P
I
N
S
I
R
K
F
S
I
V
Q
K
T
P
L
Q
720
721
M
N
G
I
E
E
D
S
D
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P
L
E
R
R
L
S
L
V
P
D
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E
Q
G
E
A
I
L
P
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I
S
V
I
S
T
G
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T
L
Q
A
R
R
R
Q
S
V
L
N
L
M
T
H
S
V
N
Q
G
780
781
Q
N
I
H
R
K
T
T
A
S
T
R
K
V
S
L
A
P
Q
A
N
L
T
E
L
D
I
Y
S
R
R
L
S
Q
E
T
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L
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I
S
E
E
I
N
E
E
D
L
K
E
C
F
F
D
D
M
E
S
I
840
841
P
A
V
T
T
W
N
T
Y
L
R
Y
I
T
V
H
K
S
L
I
F
V
L
I
W
C
L
V
I
F
L
A
E
V
A
A
S
L
V
V
L
W
L
L
G
N
T
P
L
Q
D
K
G
N
S
T
H
S
R
N
900
901
N
S
Y
A
V
I
I
T
S
T
S
S
Y
Y
V
F
Y
I
Y
V
G
V
A
D
T
L
L
A
M
G
F
F
R
G
L
P
L
V
H
T
L
I
T
V
S
K
I
L
H
H
K
M
L
H
S
V
L
Q
A
P
960
961
M
S
T
L
N
T
L
K
A
G
G
I
L
N
R
F
S
K
D
I
A
I
L
D
D
L
L
P
L
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F
I
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L
L
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V
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G
A
I
A
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V
A
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Y
I
F
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A
T
V
1020
1021
P
V
I
V
A
F
I
M
L
R
A
Y
F
L
Q
T
S
Q
Q
L
K
Q
L
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S
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G
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I
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T
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L
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T
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L
K
G
L
W
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L
R
A
F
G
R
Q
P
Y
F
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T
L
F
H
K
1080
1081
A
L
N
L
H
T
A
N
W
F
L
Y
L
S
T
L
R
W
F
Q
M
R
I
E
M
I
F
V
I
F
F
I
A
V
T
F
I
S
I
L
T
T
G
E
G
E
G
R
V
G
I
I
L
T
L
A
M
N
I
M
1140
1141
S
T
L
Q
W
A
V
N
S
S
I
D
V
D
S
L
M
R
S
V
S
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V
F
K
F
I
D
M
P
T
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G
K
P
T
K
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K
P
Y
K
N
G
Q
L
S
K
V
M
I
I
E
N
S
H
V
K
K
1200
1201
D
D
I
W
P
S
G
G
Q
M
T
V
K
D
L
T
A
K
Y
T
E
G
G
N
A
I
L
E
N
I
S
F
S
I
S
P
G
Q
R
V
G
L
L
G
R
T
G
S
G
K
S
T
L
L
S
A
F
L
R
L
1260
1261
L
N
T
E
G
E
I
Q
I
D
G
V
S
W
D
S
I
T
L
Q
Q
W
R
K
A
F
G
V
I
P
Q
K
V
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I
F
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T
F
R
K
N
L
D
P
Y
E
Q
W
S
D
Q
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I
W
K
V
A
D
1320
1321
E
V
G
L
R
S
V
I
E
Q
F
P
G
K
L
D
F
V
L
V
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G
G
C
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L
S
H
G
H
K
Q
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M
C
L
A
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S
V
L
S
K
A
K
I
L
L
L
D
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P
S
A
H
L
D
P
V
T
1380
1381
Y
Q
I
I
R
R
T
L
K
Q
A
F
A
D
C
T
V
I
L
C
E
H
R
I
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A
M
L
E
C
Q
Q
F
L
V
I
E
E
N
K
V
R
Q
Y
D
S
I
Q
K
L
L
N
E
R
S
L
F
R
Q
A
1440
1441
I
S
P
S
D
R
V
K
L
F
P
H
R
N
S
S
K
C
K
S
K
P
Q
I
A
A
L
K
E
E
T
E
E
E
V
Q
D
T
R
L
1480
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0360
Peptide:
HFVWIA
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P13569
UniProt Name:
CFTR_HUMAN
Protein Name:
Cystic fibrosis transmembrane conductance regulator (CFTR)
Position:
199-204
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.98
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
71.5
Area of the profile Above Threshold (AGGRESCAN):
4.6
Best Energy Score (PASTA 2.0):
-5.77
Aggregate Orientation (PASTA 2.0):
Parallel
