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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 781 to 810 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0781
NQSCPS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
G348C
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0782
NQSGFG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
G287S
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0783
NQYNSS
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0784
NRYQGY
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0785
NSALAL
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0786
NSATLD
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0787
NSGAAI
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0788
NSNINQ
6
Non-amyloid
Nitrogen regulatory protein GLN3
P18494
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0789
NSNLTA
6
Non-amyloid
RNA-binding suppressor of PAS kinase protein 1
Q05672
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0790
NSNNSN
6
Non-amyloid
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Q12221
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0791
NSNSSN
6
Non-amyloid
U6 snRNA-associated Sm-like protein LSm4
P40070
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0792
NSNTNT
6
Non-amyloid
Nitrogen regulatory protein GLN3
P18494
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0793
NSNTTK
6
Non-amyloid
Nucleoporin NSP1
P14907
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0794
NSNYTQ
6
Non-amyloid
Transcription factor RLM1
Q12224
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0795
NSSFNG
6
Non-amyloid
Transcription factor RLM1
Q12224
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0796
NSYSGS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0797
NTIFVQ
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0798
NTNNTS
6
Non-amyloid
Glucose repression mediator protein CYC8
P14922
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0799
NTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0800
NVAMHV
6
Non-amyloid
Transthyretin (ATTR) (Prealbumin) (TBPA)
P02766
V48M
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0801
NVAVHV
6
Non-amyloid
Transthyretin (ATTR) (Prealbumin) (TBPA)
P02766
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0802
NVNFSN
6
Non-amyloid
Asparagine-rich protein (Protein ARP)
P32770
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0803
NVTQVG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0804
NYCNFV
6
Amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
Waltz-DB 2.0, AmyLoad
P-0805
NYFAIR
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0806
NYKNFN
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0807
NYNNNL
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0808
NYNNSG
6
Non-amyloid
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Q12221
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0809
NYNNSS
6
Non-amyloid
Transcriptional activator/repressor MOT3
P54785
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0810
NYNTYR
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
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Entry: P-0781 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0781
Peptide:
NQSCPS
Length:
6
Classification:
Non-amyloid
Mutation(s):
G348C
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
345-350
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-48.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.29
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0782 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0782
Peptide:
NQSGFG
Length:
6
Classification:
Non-amyloid
Mutation(s):
G287S
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
285-290
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-46.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.85
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0783 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0783
Peptide:
NQYNSS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
159-164
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-57.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.42
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0784 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0784
Peptide:
NRYQGY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
27-32
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-44.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.57
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0785 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0785
Peptide:
NSALAL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
54-59
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.08
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.2
Area of the profile Above Threshold (AGGRESCAN):
1.18
Best Energy Score (PASTA 2.0):
-0.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0786 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0786
Peptide:
NSATLD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
99-104
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0787 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0787
Peptide:
NSGAAI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
378-383
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-28.7
Area of the profile Above Threshold (AGGRESCAN):
0.3
Best Energy Score (PASTA 2.0):
0.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0788 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
D
D
P
E
N
S
K
L
Y
D
L
L
N
S
H
L
D
V
H
G
R
S
N
E
E
P
R
Q
T
G
D
S
R
S
Q
S
S
G
N
T
G
E
N
E
E
D
I
A
F
A
S
G
L
N
G
G
T
F
60
61
D
S
M
L
E
A
L
P
D
D
L
Y
F
T
D
F
V
S
P
F
T
A
A
A
T
T
S
V
T
T
K
T
V
K
D
T
T
P
A
T
N
H
M
D
D
D
I
A
M
F
D
S
L
A
T
T
Q
P
I
D
120
121
I
A
A
S
N
Q
Q
N
G
E
I
A
Q
L
W
D
F
N
V
D
Q
F
N
M
T
P
S
N
S
S
G
S
A
T
I
S
A
P
N
S
F
T
S
D
I
P
Q
Y
N
H
G
S
L
G
N
S
V
S
K
S
180
181
S
L
F
P
Y
N
S
S
T
S
N
S
N
I
N
Q
P
S
I
N
N
N
S
N
T
N
A
Q
S
H
H
S
F
N
I
Y
K
L
Q
N
N
N
S
S
S
S
A
M
N
I
T
N
N
N
N
S
N
N
S
N
240
241
I
Q
H
P
F
L
K
K
S
D
S
I
G
L
S
S
S
N
T
T
N
S
V
R
K
N
S
L
I
K
P
M
S
S
T
S
L
A
N
F
K
R
A
A
S
V
S
S
S
I
S
N
M
E
P
S
G
Q
N
K
300
301
K
P
L
I
Q
C
F
N
C
K
T
F
K
T
P
L
W
R
R
S
P
E
G
N
T
L
C
N
A
C
G
L
F
Q
K
L
H
G
T
M
R
P
L
S
L
K
S
D
V
I
K
K
R
I
S
K
K
R
A
K
360
361
Q
T
D
P
N
I
A
Q
N
T
P
S
A
P
A
T
A
S
T
S
V
T
T
T
N
A
K
P
I
R
S
R
K
K
S
L
Q
Q
N
S
L
S
R
V
I
P
E
E
I
I
R
D
N
I
G
N
T
N
N
I
420
421
L
N
V
N
R
G
G
Y
N
F
N
S
V
P
S
P
V
L
M
N
S
Q
S
Y
N
S
S
N
A
N
F
N
G
A
S
N
A
N
L
N
S
N
N
L
M
R
H
N
S
N
T
V
T
P
N
F
R
R
S
S
480
481
R
R
S
S
T
S
S
N
T
S
S
S
S
K
S
S
S
R
S
V
V
P
I
L
P
K
P
S
P
N
S
A
N
S
Q
Q
F
N
M
N
M
N
L
M
N
T
T
N
N
V
S
A
G
N
S
V
A
S
S
P
540
541
R
I
I
S
S
A
N
F
N
S
N
S
P
L
Q
Q
N
L
L
S
N
S
F
Q
R
Q
G
M
N
I
P
R
R
K
M
S
R
N
A
S
Y
S
S
S
F
M
A
A
S
L
Q
Q
L
H
E
Q
Q
Q
V
D
600
601
V
N
S
N
T
N
T
N
S
N
R
Q
N
W
N
S
S
N
S
V
S
T
N
S
R
S
S
N
F
V
S
Q
K
P
N
F
D
I
F
N
T
P
V
D
S
P
S
V
S
R
P
S
S
R
K
S
H
T
S
L
660
661
L
S
Q
Q
L
Q
N
S
E
S
N
S
F
I
S
N
H
K
F
N
N
R
L
S
S
D
S
T
S
P
I
K
Y
E
A
D
V
S
A
G
G
K
I
S
E
D
N
S
T
K
G
S
S
K
E
S
S
A
I
A
720
721
D
E
L
D
W
L
K
F
G
I
730
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0788
Peptide:
NSNINQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P18494
UniProt Name:
GLN3_YEAST
Protein Name:
Nitrogen regulatory protein GLN3
Position:
191-196
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.26
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0789 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
A
L
D
S
R
N
W
G
L
T
P
A
M
E
T
G
L
F
Q
K
P
Q
D
R
I
F
I
I
E
L
E
N
S
I
V
S
F
I
N
S
N
T
E
S
F
Q
L
R
P
M
N
S
Y
Y
R
L
L
S
60
61
H
Q
I
A
E
Y
H
N
L
N
H
V
L
A
R
T
Q
D
S
C
V
I
L
F
K
G
E
N
F
Q
K
I
E
G
K
P
L
L
Q
E
L
Q
L
N
K
K
P
E
E
C
A
S
S
S
E
S
I
E
K
S
120
121
N
N
N
R
I
F
R
I
L
K
R
K
E
V
G
N
E
C
D
Y
K
I
D
G
N
T
R
T
P
N
S
N
L
T
A
N
S
N
K
D
Q
K
I
E
I
D
D
K
S
S
T
D
L
E
Q
E
R
I
E
K
180
181
E
R
L
Y
E
Q
R
K
Q
E
I
F
D
K
L
N
K
S
E
D
D
V
K
S
T
N
S
S
G
S
S
D
S
D
N
E
W
S
D
W
L
N
G
D
D
S
N
T
Q
T
S
N
G
S
V
S
S
S
S
P
240
241
F
N
S
S
V
T
T
I
Q
V
N
K
P
Q
Q
Q
F
Y
D
S
R
R
G
R
G
G
R
R
R
G
T
N
N
Y
K
D
A
Y
R
G
Q
S
R
R
N
K
E
N
G
G
Y
Q
S
G
Y
S
S
P
Y
L
300
301
V
Y
P
P
P
Q
M
G
G
N
S
L
P
T
Y
P
L
M
Y
N
P
A
G
P
A
P
G
P
A
P
S
P
M
V
M
G
N
N
T
V
F
M
N
P
Y
M
Y
N
M
N
P
Q
G
S
C
S
F
G
T
P
360
361
I
P
M
Y
P
P
Y
Q
Y
Q
Y
Q
Y
Q
Y
N
T
Q
Y
H
S
G
P
Y
S
N
T
P
S
Y
N
S
N
N
Y
T
R
S
S
A
N
K
Y
H
H
F
Q
G
K
N
S
Y
S
G
A
I
P
K
R
S
420
421
D
D
S
N
S
N
K
N
E
G
I
R
R
A
S
V
E
G
S
P
S
S
R
D
T
D
S
V
E
M
K
F
D
K
L
N
I
457
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0789
Peptide:
NSNLTA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q05672
UniProt Name:
RBS1_YEAST
Protein Name:
RNA-binding suppressor of PAS kinase protein 1
Position:
150-155
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.41
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-35.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.31
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0790 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
N
K
R
L
Y
N
G
N
L
S
N
I
P
E
V
I
D
P
G
I
T
I
P
I
Y
E
E
D
I
R
N
D
T
R
M
N
T
N
A
R
S
V
R
V
S
D
K
R
G
R
S
S
S
T
S
P
Q
K
60
61
I
G
S
Y
R
T
R
A
G
R
F
S
D
T
L
T
N
L
L
P
S
I
S
A
K
L
H
H
S
K
K
S
T
P
V
V
V
V
P
P
T
S
S
T
P
D
S
L
N
S
T
T
Y
A
P
R
V
S
S
D
120
121
S
F
T
V
A
T
P
L
S
L
Q
S
T
T
T
R
T
R
T
R
N
N
T
V
S
S
Q
I
T
A
S
S
S
L
T
T
D
V
G
N
A
T
S
A
N
I
W
S
A
N
A
E
S
N
T
S
S
S
P
L
180
181
F
D
Y
P
L
A
T
S
Y
F
E
P
L
T
R
F
K
S
T
D
N
Y
T
L
P
Q
T
A
Q
L
N
S
F
L
E
K
N
G
N
P
N
I
W
S
S
A
G
N
S
N
T
D
H
L
N
T
P
I
V
N
240
241
R
Q
R
S
Q
S
Q
S
T
T
N
R
V
Y
T
D
A
P
Y
Y
Q
Q
P
A
Q
N
Y
Q
V
Q
V
P
P
R
V
P
K
S
T
S
I
S
P
V
I
L
D
D
V
D
P
A
S
I
N
W
I
T
A
N
300
301
Q
K
V
P
L
V
N
Q
I
S
A
L
L
P
T
N
T
I
S
I
S
N
V
F
P
L
Q
P
T
Q
Q
H
Q
Q
N
A
V
N
L
T
S
T
S
L
A
T
L
C
S
Q
Y
G
K
V
L
S
A
R
T
L
360
361
R
G
L
N
M
A
L
V
E
F
S
T
V
E
S
A
I
C
A
L
E
A
L
Q
G
K
E
L
S
K
V
G
A
P
S
T
V
S
F
A
R
V
L
P
M
Y
E
Q
P
L
N
V
N
G
F
N
N
T
P
K
420
421
Q
P
L
L
Q
E
Q
L
N
H
G
V
L
N
Y
Q
L
Q
Q
S
L
Q
Q
P
E
L
Q
Q
Q
P
T
S
F
N
Q
P
N
L
T
Y
C
N
P
T
Q
N
L
S
H
L
Q
L
S
S
N
E
N
E
P
Y
480
481
P
F
P
L
P
P
P
S
L
S
D
S
K
K
D
I
L
H
T
I
S
S
F
K
L
E
Y
D
H
L
E
L
N
H
L
L
Q
N
A
L
K
N
K
G
V
S
D
T
N
Y
F
G
P
L
P
E
H
N
S
K
540
541
V
P
K
R
K
D
T
F
D
A
P
K
L
R
E
L
R
K
Q
F
D
S
N
S
L
S
T
I
E
M
E
Q
L
A
I
V
M
L
D
Q
L
P
E
L
S
S
D
Y
L
G
N
T
V
I
Q
K
L
F
E
N
600
601
S
S
N
I
I
R
D
I
M
L
R
K
C
N
K
Y
L
T
S
M
G
V
H
K
N
G
T
W
V
C
Q
K
I
I
K
M
A
N
T
P
R
Q
I
N
L
V
T
S
G
V
S
D
Y
C
T
P
L
F
N
D
660
661
Q
F
G
N
Y
V
I
Q
G
I
L
K
F
G
F
P
W
N
S
F
I
F
E
S
V
L
S
H
F
W
T
I
V
Q
N
R
Y
G
S
R
A
V
R
A
C
L
E
A
D
S
I
I
T
Q
C
Q
L
L
T
I
720
721
T
S
L
I
I
V
L
S
P
Y
L
A
T
D
T
N
G
T
L
L
I
T
W
L
L
D
T
C
T
L
P
N
K
N
L
I
L
C
D
K
L
V
N
K
N
L
V
K
L
C
C
H
K
L
G
S
L
T
V
L
780
781
K
I
L
N
L
R
G
G
E
E
E
A
L
S
K
N
K
I
I
H
A
I
F
D
G
P
I
S
S
D
S
I
L
F
Q
I
L
D
E
G
N
Y
G
P
T
F
I
Y
K
V
L
T
S
R
I
L
D
N
S
V
840
841
R
D
E
A
I
T
K
I
R
Q
L
I
L
N
S
N
I
N
L
Q
S
R
Q
L
L
E
E
V
G
L
S
S
A
G
I
S
P
K
Q
S
S
K
N
H
R
K
Q
H
P
Q
G
F
H
S
P
G
R
A
R
G
900
901
V
S
V
S
S
V
R
S
S
N
S
R
H
N
S
V
I
Q
M
N
N
A
G
P
T
P
A
L
N
F
N
P
A
P
M
S
E
I
N
S
Y
F
N
N
Q
Q
V
V
Y
S
G
N
Q
N
Q
N
Q
N
G
N
960
961
S
N
G
L
D
E
L
N
S
Q
F
D
S
F
R
I
A
N
G
T
N
L
S
L
P
I
V
N
L
P
N
V
S
N
N
N
N
N
Y
N
N
S
G
Y
S
S
Q
M
N
P
L
S
R
S
V
S
H
N
N
N
1020
1021
N
N
T
N
N
Y
N
N
N
D
N
D
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
S
N
N
S
N
N
N
N
N
N
D
T
S
L
Y
R
Y
R
S
Y
G
Y
1075
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0790
Peptide:
NSNNSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12221
UniProt Name:
PUF2_YEAST
Protein Name:
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Position:
1053-1058
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-104.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0791 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
L
Y
L
L
T
N
A
K
G
Q
Q
M
Q
I
E
L
K
N
G
E
I
I
Q
G
I
L
T
N
V
D
N
W
M
N
L
T
L
S
N
V
T
E
Y
S
E
E
S
A
I
N
S
E
D
N
A
E
S
60
61
S
K
A
V
K
L
N
E
I
Y
I
R
G
T
F
I
K
F
I
K
L
Q
D
N
I
I
D
K
V
K
Q
Q
I
N
S
N
N
N
S
N
S
N
G
P
G
H
K
R
Y
Y
N
N
R
D
S
N
N
N
R
G
120
121
N
Y
N
R
R
N
N
N
N
G
N
S
N
R
R
P
Y
S
Q
N
R
Q
Y
N
N
S
N
S
S
N
I
N
N
S
I
N
S
I
N
S
N
N
Q
N
M
N
N
G
L
G
G
S
V
Q
H
H
F
N
S
S
180
181
S
P
Q
K
V
E
F
187
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0791
Peptide:
NSNSSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P40070
UniProt Name:
LSM4_YEAST
Protein Name:
U6 snRNA-associated Sm-like protein LSm4
Position:
145-150
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-83.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.06
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0792 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
D
D
P
E
N
S
K
L
Y
D
L
L
N
S
H
L
D
V
H
G
R
S
N
E
E
P
R
Q
T
G
D
S
R
S
Q
S
S
G
N
T
G
E
N
E
E
D
I
A
F
A
S
G
L
N
G
G
T
F
60
61
D
S
M
L
E
A
L
P
D
D
L
Y
F
T
D
F
V
S
P
F
T
A
A
A
T
T
S
V
T
T
K
T
V
K
D
T
T
P
A
T
N
H
M
D
D
D
I
A
M
F
D
S
L
A
T
T
Q
P
I
D
120
121
I
A
A
S
N
Q
Q
N
G
E
I
A
Q
L
W
D
F
N
V
D
Q
F
N
M
T
P
S
N
S
S
G
S
A
T
I
S
A
P
N
S
F
T
S
D
I
P
Q
Y
N
H
G
S
L
G
N
S
V
S
K
S
180
181
S
L
F
P
Y
N
S
S
T
S
N
S
N
I
N
Q
P
S
I
N
N
N
S
N
T
N
A
Q
S
H
H
S
F
N
I
Y
K
L
Q
N
N
N
S
S
S
S
A
M
N
I
T
N
N
N
N
S
N
N
S
N
240
241
I
Q
H
P
F
L
K
K
S
D
S
I
G
L
S
S
S
N
T
T
N
S
V
R
K
N
S
L
I
K
P
M
S
S
T
S
L
A
N
F
K
R
A
A
S
V
S
S
S
I
S
N
M
E
P
S
G
Q
N
K
300
301
K
P
L
I
Q
C
F
N
C
K
T
F
K
T
P
L
W
R
R
S
P
E
G
N
T
L
C
N
A
C
G
L
F
Q
K
L
H
G
T
M
R
P
L
S
L
K
S
D
V
I
K
K
R
I
S
K
K
R
A
K
360
361
Q
T
D
P
N
I
A
Q
N
T
P
S
A
P
A
T
A
S
T
S
V
T
T
T
N
A
K
P
I
R
S
R
K
K
S
L
Q
Q
N
S
L
S
R
V
I
P
E
E
I
I
R
D
N
I
G
N
T
N
N
I
420
421
L
N
V
N
R
G
G
Y
N
F
N
S
V
P
S
P
V
L
M
N
S
Q
S
Y
N
S
S
N
A
N
F
N
G
A
S
N
A
N
L
N
S
N
N
L
M
R
H
N
S
N
T
V
T
P
N
F
R
R
S
S
480
481
R
R
S
S
T
S
S
N
T
S
S
S
S
K
S
S
S
R
S
V
V
P
I
L
P
K
P
S
P
N
S
A
N
S
Q
Q
F
N
M
N
M
N
L
M
N
T
T
N
N
V
S
A
G
N
S
V
A
S
S
P
540
541
R
I
I
S
S
A
N
F
N
S
N
S
P
L
Q
Q
N
L
L
S
N
S
F
Q
R
Q
G
M
N
I
P
R
R
K
M
S
R
N
A
S
Y
S
S
S
F
M
A
A
S
L
Q
Q
L
H
E
Q
Q
Q
V
D
600
601
V
N
S
N
T
N
T
N
S
N
R
Q
N
W
N
S
S
N
S
V
S
T
N
S
R
S
S
N
F
V
S
Q
K
P
N
F
D
I
F
N
T
P
V
D
S
P
S
V
S
R
P
S
S
R
K
S
H
T
S
L
660
661
L
S
Q
Q
L
Q
N
S
E
S
N
S
F
I
S
N
H
K
F
N
N
R
L
S
S
D
S
T
S
P
I
K
Y
E
A
D
V
S
A
G
G
K
I
S
E
D
N
S
T
K
G
S
S
K
E
S
S
A
I
A
720
721
D
E
L
D
W
L
K
F
G
I
730
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0792
Peptide:
NSNTNT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P18494
UniProt Name:
GLN3_YEAST
Protein Name:
Nitrogen regulatory protein GLN3
Position:
602-607
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-83.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0793 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
F
N
T
P
Q
Q
N
K
T
P
F
S
F
G
T
A
N
N
N
S
N
T
T
N
Q
N
S
S
T
G
A
G
A
F
G
T
G
Q
S
T
F
G
F
N
N
S
A
P
N
N
T
N
N
A
N
S
S
I
60
61
T
P
A
F
G
S
N
N
T
G
N
T
A
F
G
N
S
N
P
T
S
N
V
F
G
S
N
N
S
T
T
N
T
F
G
S
N
S
A
G
T
S
L
F
G
S
S
S
A
Q
Q
T
K
S
N
G
T
A
G
G
120
121
N
T
F
G
S
S
S
L
F
N
N
S
T
N
S
N
T
T
K
P
A
F
G
G
L
N
F
G
G
G
N
N
T
T
P
S
S
T
G
N
A
N
T
S
N
N
L
F
G
A
T
A
N
A
N
K
P
A
F
S
180
181
F
G
A
T
T
N
D
D
K
K
T
E
P
D
K
P
A
F
S
F
N
S
S
V
G
N
K
T
D
A
Q
A
P
T
T
G
F
S
F
G
S
Q
L
G
G
N
K
T
V
N
E
A
A
K
P
S
L
S
F
G
240
241
S
G
S
A
G
A
N
P
A
G
A
S
Q
P
E
P
T
T
N
E
P
A
K
P
A
L
S
F
G
T
A
T
S
D
N
K
T
T
N
T
T
P
S
F
S
F
G
A
K
S
D
E
N
K
A
G
A
T
S
K
300
301
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
360
361
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
P
D
E
N
K
A
S
A
T
S
K
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
420
421
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
S
480
481
D
E
K
K
D
S
D
S
S
K
P
A
F
S
F
G
T
K
S
N
E
K
K
D
S
G
S
S
K
P
A
F
S
F
G
A
K
P
D
E
K
K
N
D
E
V
S
K
P
A
F
S
F
G
A
K
A
N
E
K
540
541
K
E
S
D
E
S
K
S
A
F
S
F
G
S
K
P
T
G
K
E
E
G
D
G
A
K
A
A
I
S
F
G
A
K
P
E
E
Q
K
S
S
D
T
S
K
P
A
F
T
F
G
A
Q
K
D
N
E
K
K
T
600
601
E
E
S
S
T
G
K
S
T
A
D
V
K
S
S
D
S
L
K
L
N
S
K
P
V
E
L
K
P
V
S
L
D
N
K
T
L
D
D
L
V
T
K
W
T
N
Q
L
T
E
S
A
S
H
F
E
Q
Y
T
K
660
661
K
I
N
S
W
D
Q
V
L
V
K
G
G
E
Q
I
S
Q
L
Y
S
D
A
V
M
A
E
H
S
Q
N
K
I
D
Q
S
L
Q
Y
I
E
R
Q
Q
D
E
L
E
N
F
L
D
N
F
E
T
K
T
E
A
720
721
L
L
S
D
V
V
S
T
S
S
G
A
A
A
N
N
N
D
Q
K
R
Q
Q
A
Y
K
T
A
Q
T
L
D
E
N
L
N
S
L
S
S
N
L
S
S
L
I
V
E
I
N
N
V
S
N
T
F
N
K
T
T
780
781
N
I
D
I
N
N
E
D
E
N
I
Q
L
I
K
I
L
N
S
H
F
D
A
L
R
S
L
D
D
N
S
T
S
L
E
K
Q
I
N
S
I
K
K
823
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0793
Peptide:
NSNTTK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14907
UniProt Name:
NSP1_YEAST
Protein Name:
Nucleoporin NSP1
Position:
134-139
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-75.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.02
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0794 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
R
R
K
I
E
I
Q
R
I
S
D
D
R
N
R
A
V
T
F
I
K
R
K
A
G
L
F
K
K
A
H
E
L
S
V
L
C
Q
V
D
I
A
V
I
I
L
G
S
N
N
T
F
Y
E
F
S
S
V
60
61
D
T
N
D
L
I
Y
H
Y
Q
N
D
K
N
L
L
H
E
V
K
D
P
S
D
Y
G
D
F
H
K
S
A
S
V
N
I
N
Q
D
L
L
R
S
S
M
S
N
K
P
S
K
S
N
V
K
G
M
N
Q
S
120
121
E
N
D
D
D
E
N
N
D
E
D
D
D
D
H
G
N
F
E
R
N
S
N
M
H
S
N
K
K
A
S
D
K
N
I
P
S
A
H
M
K
L
L
S
P
T
A
L
I
S
K
M
D
G
S
E
Q
N
K
R
180
181
H
P
E
N
A
L
P
P
L
Q
H
L
K
R
L
K
P
D
P
L
Q
I
S
R
T
P
Q
Q
Q
Q
Q
Q
N
I
S
R
P
Y
H
S
S
M
Y
N
L
N
Q
P
S
S
S
S
S
S
P
S
T
M
D
F
240
241
P
K
L
P
S
F
Q
N
S
S
F
N
G
R
P
P
P
I
S
I
S
P
N
K
F
S
K
P
F
T
N
A
S
S
R
T
P
K
Q
E
H
K
I
N
N
S
G
S
N
N
N
D
N
S
N
Y
T
Q
S
P
300
301
S
N
S
L
E
D
S
I
Q
Q
T
V
K
A
R
R
K
L
S
A
R
P
V
L
R
V
R
I
P
N
N
N
F
S
S
N
S
A
I
P
S
E
P
S
S
A
S
S
T
S
A
N
G
N
S
M
G
S
S
Q
360
361
I
M
K
E
N
K
T
S
R
S
S
K
I
S
P
L
S
A
S
A
S
G
P
L
T
L
Q
K
G
N
N
G
R
M
V
I
K
L
P
N
A
N
A
P
N
G
S
N
N
G
N
G
S
N
N
N
N
H
P
Y
420
421
P
F
G
S
G
S
S
P
L
F
S
A
T
Q
P
Y
I
A
T
P
L
Q
P
S
N
I
P
G
G
P
F
Q
Q
N
T
S
F
L
A
Q
R
Q
T
Q
Q
Y
Q
Q
M
S
F
K
K
Q
S
Q
T
V
P
L
480
481
T
T
T
L
T
G
R
P
P
S
T
F
S
G
P
E
T
S
N
G
P
P
T
G
S
L
P
S
K
F
V
H
D
L
M
S
N
S
P
N
V
S
S
I
S
M
F
P
D
W
S
M
G
P
N
S
A
K
P
G
540
541
N
T
N
N
P
G
T
F
P
P
V
Q
T
A
V
N
N
G
N
S
S
N
I
S
S
T
N
N
T
N
N
N
N
N
N
N
N
N
N
S
S
N
N
N
S
N
N
G
N
D
N
N
S
N
N
S
N
N
S
Y
600
601
Y
S
N
N
E
D
A
P
V
N
G
A
A
I
S
E
H
T
T
D
G
D
S
N
N
Q
S
N
S
S
T
Y
D
A
A
A
T
A
Y
N
G
N
T
G
L
T
P
Y
I
N
T
A
Q
T
P
L
G
T
K
F
660
661
F
N
F
S
T
D
I
S
G
E
K
N
S
S
K
I
676
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0794
Peptide:
NSNYTQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12224
UniProt Name:
RLM1_YEAST
Protein Name:
Transcription factor RLM1
Position:
293-298
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-52.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0795 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
R
R
K
I
E
I
Q
R
I
S
D
D
R
N
R
A
V
T
F
I
K
R
K
A
G
L
F
K
K
A
H
E
L
S
V
L
C
Q
V
D
I
A
V
I
I
L
G
S
N
N
T
F
Y
E
F
S
S
V
60
61
D
T
N
D
L
I
Y
H
Y
Q
N
D
K
N
L
L
H
E
V
K
D
P
S
D
Y
G
D
F
H
K
S
A
S
V
N
I
N
Q
D
L
L
R
S
S
M
S
N
K
P
S
K
S
N
V
K
G
M
N
Q
S
120
121
E
N
D
D
D
E
N
N
D
E
D
D
D
D
H
G
N
F
E
R
N
S
N
M
H
S
N
K
K
A
S
D
K
N
I
P
S
A
H
M
K
L
L
S
P
T
A
L
I
S
K
M
D
G
S
E
Q
N
K
R
180
181
H
P
E
N
A
L
P
P
L
Q
H
L
K
R
L
K
P
D
P
L
Q
I
S
R
T
P
Q
Q
Q
Q
Q
Q
N
I
S
R
P
Y
H
S
S
M
Y
N
L
N
Q
P
S
S
S
S
S
S
P
S
T
M
D
F
240
241
P
K
L
P
S
F
Q
N
S
S
F
N
G
R
P
P
P
I
S
I
S
P
N
K
F
S
K
P
F
T
N
A
S
S
R
T
P
K
Q
E
H
K
I
N
N
S
G
S
N
N
N
D
N
S
N
Y
T
Q
S
P
300
301
S
N
S
L
E
D
S
I
Q
Q
T
V
K
A
R
R
K
L
S
A
R
P
V
L
R
V
R
I
P
N
N
N
F
S
S
N
S
A
I
P
S
E
P
S
S
A
S
S
T
S
A
N
G
N
S
M
G
S
S
Q
360
361
I
M
K
E
N
K
T
S
R
S
S
K
I
S
P
L
S
A
S
A
S
G
P
L
T
L
Q
K
G
N
N
G
R
M
V
I
K
L
P
N
A
N
A
P
N
G
S
N
N
G
N
G
S
N
N
N
N
H
P
Y
420
421
P
F
G
S
G
S
S
P
L
F
S
A
T
Q
P
Y
I
A
T
P
L
Q
P
S
N
I
P
G
G
P
F
Q
Q
N
T
S
F
L
A
Q
R
Q
T
Q
Q
Y
Q
Q
M
S
F
K
K
Q
S
Q
T
V
P
L
480
481
T
T
T
L
T
G
R
P
P
S
T
F
S
G
P
E
T
S
N
G
P
P
T
G
S
L
P
S
K
F
V
H
D
L
M
S
N
S
P
N
V
S
S
I
S
M
F
P
D
W
S
M
G
P
N
S
A
K
P
G
540
541
N
T
N
N
P
G
T
F
P
P
V
Q
T
A
V
N
N
G
N
S
S
N
I
S
S
T
N
N
T
N
N
N
N
N
N
N
N
N
N
S
S
N
N
N
S
N
N
G
N
D
N
N
S
N
N
S
N
N
S
Y
600
601
Y
S
N
N
E
D
A
P
V
N
G
A
A
I
S
E
H
T
T
D
G
D
S
N
N
Q
S
N
S
S
T
Y
D
A
A
A
T
A
Y
N
G
N
T
G
L
T
P
Y
I
N
T
A
Q
T
P
L
G
T
K
F
660
661
F
N
F
S
T
D
I
S
G
E
K
N
S
S
K
I
676
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0795
Peptide:
NSSFNG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12224
UniProt Name:
RLM1_YEAST
Protein Name:
Transcription factor RLM1
Position:
248-253
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-28.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0796 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0796
Peptide:
NSYSGS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
372-377
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-27.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.61
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0797 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0797
Peptide:
NTIFVQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
285-290
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
47.3
Area of the profile Above Threshold (AGGRESCAN):
3.02
Best Energy Score (PASTA 2.0):
-4.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0798 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
P
G
G
E
Q
T
I
M
E
Q
P
A
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
A
A
V
P
Q
Q
P
L
D
P
L
T
Q
S
T
A
E
T
W
L
S
I
A
S
L
A
E
T
L
G
60
61
D
G
D
R
A
A
M
A
Y
D
A
T
L
Q
F
N
P
S
S
A
K
A
L
T
S
L
A
H
L
Y
R
S
R
D
M
F
Q
R
A
A
E
L
Y
E
R
A
L
L
V
N
P
E
L
S
D
V
W
A
T
L
120
121
G
H
C
Y
L
M
L
D
D
L
Q
R
A
Y
N
A
Y
Q
Q
A
L
Y
H
L
S
N
P
N
V
P
K
L
W
H
G
I
G
I
L
Y
D
R
Y
G
S
L
D
Y
A
E
E
A
F
A
K
V
L
E
L
D
180
181
P
H
F
E
K
A
N
E
I
Y
F
R
L
G
I
I
Y
K
H
Q
G
K
W
S
Q
A
L
E
C
F
R
Y
I
L
P
Q
P
P
A
P
L
Q
E
W
D
I
W
F
Q
L
G
S
V
L
E
S
M
G
E
W
240
241
Q
G
A
K
E
A
Y
E
H
V
L
A
Q
N
Q
H
H
A
K
V
L
Q
Q
L
G
C
L
Y
G
M
S
N
V
Q
F
Y
D
P
Q
K
A
L
D
Y
L
L
K
S
L
E
A
D
P
S
D
A
T
T
W
Y
300
301
H
L
G
R
V
H
M
I
R
T
D
Y
T
A
A
Y
D
A
F
Q
Q
A
V
N
R
D
S
R
N
P
I
F
W
C
S
I
G
V
L
Y
Y
Q
I
S
Q
Y
R
D
A
L
D
A
Y
T
R
A
I
R
L
N
360
361
P
Y
I
S
E
V
W
Y
D
L
G
T
L
Y
E
T
C
N
N
Q
L
S
D
A
L
D
A
Y
K
Q
A
A
R
L
D
V
N
N
V
H
I
R
E
R
L
E
A
L
T
K
Q
L
E
N
P
G
N
I
N
K
420
421
S
N
G
A
P
T
N
A
S
P
A
P
P
P
V
I
L
Q
P
T
L
Q
P
N
D
Q
G
N
P
L
N
T
R
I
S
A
Q
S
A
N
A
T
A
S
M
V
Q
Q
Q
H
P
A
Q
Q
T
P
I
N
S
S
480
481
A
T
M
Y
S
N
G
A
S
P
Q
L
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
H
A
Q
A
540
541
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
L
Q
P
L
P
R
Q
Q
L
Q
Q
K
G
600
601
V
S
V
Q
M
L
N
P
Q
Q
G
Q
P
Y
I
T
Q
P
T
V
I
Q
A
H
Q
L
Q
P
F
S
T
Q
A
M
E
H
P
Q
S
S
Q
L
P
P
Q
Q
Q
Q
L
Q
S
V
Q
H
P
Q
Q
L
Q
G
660
661
Q
P
Q
A
Q
A
P
Q
P
L
I
Q
H
N
V
E
Q
N
V
L
P
Q
K
R
Y
M
E
G
A
I
H
T
L
V
D
A
A
V
S
S
S
T
H
T
E
N
N
T
K
S
P
R
Q
P
T
H
A
I
P
T
720
721
Q
A
P
A
T
G
I
T
N
A
E
P
Q
V
K
K
Q
K
L
N
S
P
N
S
N
I
N
K
L
V
N
T
A
T
S
I
E
E
N
A
K
S
E
V
S
N
Q
S
P
A
V
V
E
S
N
T
N
N
T
S
780
781
Q
E
E
K
P
V
K
A
N
S
I
P
S
V
I
G
A
Q
E
P
P
Q
E
A
S
P
A
E
E
A
T
K
A
A
S
V
S
P
S
T
K
P
L
N
T
E
P
E
S
S
S
V
Q
P
T
V
S
S
E
S
840
841
S
T
T
K
A
N
D
Q
S
T
A
E
T
I
E
L
S
T
A
T
V
P
A
E
A
S
P
V
E
D
E
V
R
Q
H
S
K
E
E
N
G
T
T
E
A
S
A
P
S
T
E
E
A
E
P
A
A
S
R
D
900
901
A
E
K
Q
Q
D
E
T
A
A
T
T
I
T
V
I
K
P
T
L
E
T
M
E
T
V
K
E
E
A
K
M
R
E
E
E
Q
T
S
Q
E
K
S
P
Q
E
N
T
L
P
R
E
N
V
V
R
Q
V
E
E
960
961
D
E
N
Y
D
D
966
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0798
Peptide:
NTNNTS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14922
UniProt Name:
CYC8_YEAST
Protein Name:
Glucose repression mediator protein CYC8
Position:
775-780
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-90.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0799 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0799
Peptide:
NTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
45.3
Area of the profile Above Threshold (AGGRESCAN):
2.88
Best Energy Score (PASTA 2.0):
-6.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0800 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
H
R
L
L
L
L
C
L
A
G
L
V
F
V
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
M
V
K
V
L
D
A
V
R
G
S
P
A
I
N
V
A
V
H
V
F
R
K
A
A
D
D
T
60
61
W
E
P
F
A
S
G
K
T
S
E
S
G
E
L
H
G
L
T
T
E
E
E
F
V
E
G
I
Y
K
V
E
I
D
T
K
S
Y
W
K
A
L
G
I
S
P
F
H
E
H
A
E
V
V
F
T
A
N
D
S
120
121
G
P
R
R
Y
T
I
A
A
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
P
K
E
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0800
Peptide:
NVAMHV
Length:
6
Classification:
Non-amyloid
Mutation(s):
V48M
Structure(s):
No structures
Protein Information
UniProt ID:
P02766
UniProt Name:
TTHY_HUMAN
Protein Name:
Transthyretin (ATTR) (Prealbumin) (TBPA)
Position:
45-50
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.8
Area of the profile Above Threshold (AGGRESCAN):
0.85
Best Energy Score (PASTA 2.0):
-3.6
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0801 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
H
R
L
L
L
L
C
L
A
G
L
V
F
V
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
M
V
K
V
L
D
A
V
R
G
S
P
A
I
N
V
A
V
H
V
F
R
K
A
A
D
D
T
60
61
W
E
P
F
A
S
G
K
T
S
E
S
G
E
L
H
G
L
T
T
E
E
E
F
V
E
G
I
Y
K
V
E
I
D
T
K
S
Y
W
K
A
L
G
I
S
P
F
H
E
H
A
E
V
V
F
T
A
N
D
S
120
121
G
P
R
R
Y
T
I
A
A
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
P
K
E
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0801
Peptide:
NVAVHV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02766
UniProt Name:
TTHY_HUMAN
Protein Name:
Transthyretin (ATTR) (Prealbumin) (TBPA)
Position:
47-52
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.82
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.5
Area of the profile Above Threshold (AGGRESCAN):
1.56
Best Energy Score (PASTA 2.0):
-5.43
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0802 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
H
Y
V
V
L
E
L
Q
V
A
H
L
P
D
T
P
K
D
Q
C
R
I
A
N
I
A
F
Q
I
V
N
A
E
T
L
V
C
H
Y
G
T
N
S
L
P
S
I
E
V
N
G
T
T
K
S
L
E
S
A
60
61
M
V
Q
L
D
K
D
I
H
D
V
I
G
N
D
D
F
V
L
V
S
L
Y
S
T
W
H
I
R
V
T
L
P
R
Q
A
R
D
D
G
F
I
L
T
S
Y
L
Q
H
P
K
V
F
D
L
W
K
E
F
D
120
121
R
W
C
V
N
H
P
E
I
L
G
Q
K
K
A
I
S
N
N
N
C
N
T
K
S
I
S
I
N
A
A
K
N
T
K
D
L
D
E
I
V
R
I
L
E
V
S
I
P
T
E
E
A
G
S
V
P
E
I
Y
180
181
S
L
L
K
R
T
T
D
I
L
I
Q
L
H
K
K
C
T
S
P
E
D
M
E
S
V
L
T
K
P
Y
D
S
H
T
D
I
R
A
F
L
Q
E
K
S
K
I
L
Y
M
N
N
L
P
P
D
T
T
Q
S
240
241
E
L
E
S
W
F
T
Q
Y
G
V
R
P
V
G
F
W
T
V
K
N
I
V
E
D
T
S
N
V
N
N
N
W
S
L
N
N
S
P
Y
V
E
D
Q
D
S
I
S
G
F
V
V
F
Q
T
H
E
E
A
T
300
301
E
V
L
A
L
N
G
R
S
I
L
S
N
L
A
N
T
K
Q
P
R
V
V
E
H
V
L
E
L
Q
P
S
S
T
G
V
L
D
K
A
Q
E
I
L
S
P
F
P
Q
S
K
N
K
P
R
P
G
D
W
N
360
361
C
P
S
C
G
F
S
N
F
Q
R
R
T
A
C
F
R
C
S
F
P
A
P
S
N
S
Q
I
H
T
A
N
S
N
N
N
V
N
S
S
R
N
N
L
N
N
R
V
N
S
G
S
S
S
N
I
S
N
T
A
420
421
A
N
H
P
Y
G
A
P
E
F
N
M
I
A
N
N
T
P
A
A
L
T
Y
N
R
A
H
F
P
A
I
T
P
L
S
R
Q
N
S
L
N
M
A
P
S
N
S
G
S
P
I
I
I
A
D
H
F
S
G
N
480
481
N
N
I
A
P
N
Y
R
Y
N
N
N
I
N
N
N
N
N
N
I
N
N
M
T
N
N
R
Y
N
I
N
N
N
I
N
G
N
G
N
G
N
G
N
N
S
N
N
N
N
N
H
N
N
N
H
N
N
N
H
H
540
541
N
G
S
I
N
S
N
S
N
T
N
N
N
N
N
N
N
N
G
N
N
S
N
N
C
N
S
N
I
G
M
G
G
C
G
S
N
M
P
F
R
A
G
D
W
K
C
S
T
C
T
Y
H
N
F
A
K
N
V
V
600
601
C
L
R
C
G
G
P
K
S
I
S
G
D
A
S
E
T
N
H
Y
I
D
S
S
T
F
G
P
A
S
R
T
P
S
N
N
N
I
S
V
N
T
N
G
G
S
N
A
G
R
T
D
G
N
D
N
K
G
R
D
660
661
I
S
L
M
E
F
M
S
P
P
L
S
M
A
T
K
S
M
K
E
G
D
G
N
G
S
S
F
N
E
F
K
S
D
K
A
N
V
N
F
S
N
V
G
D
N
S
A
F
G
N
G
F
N
S
S
I
R
W
719
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0802
Peptide:
NVNFSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32770
UniProt Name:
NRP1_YEAST
Protein Name:
Asparagine-rich protein (Protein ARP)
Position:
697-702
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-17.7
Area of the profile Above Threshold (AGGRESCAN):
0.22
Best Energy Score (PASTA 2.0):
-2.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0803 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0803
Peptide:
NVTQVG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
136-141
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-21.7
Area of the profile Above Threshold (AGGRESCAN):
0.39
Best Energy Score (PASTA 2.0):
-2.92
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0804 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0804
Peptide:
NYCNFV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.93
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.7
Area of the profile Above Threshold (AGGRESCAN):
1.65
Best Energy Score (PASTA 2.0):
-3.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0805 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0805
Peptide:
NYFAIR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.37
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
30.6
Area of the profile Above Threshold (AGGRESCAN):
1.96
Best Energy Score (PASTA 2.0):
-2.8
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0806 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0806
Peptide:
NYKNFN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
100-105
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-49.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.03
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0807 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0807
Peptide:
NYNNNL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
105-110
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.16
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-71.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0808 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
N
K
R
L
Y
N
G
N
L
S
N
I
P
E
V
I
D
P
G
I
T
I
P
I
Y
E
E
D
I
R
N
D
T
R
M
N
T
N
A
R
S
V
R
V
S
D
K
R
G
R
S
S
S
T
S
P
Q
K
60
61
I
G
S
Y
R
T
R
A
G
R
F
S
D
T
L
T
N
L
L
P
S
I
S
A
K
L
H
H
S
K
K
S
T
P
V
V
V
V
P
P
T
S
S
T
P
D
S
L
N
S
T
T
Y
A
P
R
V
S
S
D
120
121
S
F
T
V
A
T
P
L
S
L
Q
S
T
T
T
R
T
R
T
R
N
N
T
V
S
S
Q
I
T
A
S
S
S
L
T
T
D
V
G
N
A
T
S
A
N
I
W
S
A
N
A
E
S
N
T
S
S
S
P
L
180
181
F
D
Y
P
L
A
T
S
Y
F
E
P
L
T
R
F
K
S
T
D
N
Y
T
L
P
Q
T
A
Q
L
N
S
F
L
E
K
N
G
N
P
N
I
W
S
S
A
G
N
S
N
T
D
H
L
N
T
P
I
V
N
240
241
R
Q
R
S
Q
S
Q
S
T
T
N
R
V
Y
T
D
A
P
Y
Y
Q
Q
P
A
Q
N
Y
Q
V
Q
V
P
P
R
V
P
K
S
T
S
I
S
P
V
I
L
D
D
V
D
P
A
S
I
N
W
I
T
A
N
300
301
Q
K
V
P
L
V
N
Q
I
S
A
L
L
P
T
N
T
I
S
I
S
N
V
F
P
L
Q
P
T
Q
Q
H
Q
Q
N
A
V
N
L
T
S
T
S
L
A
T
L
C
S
Q
Y
G
K
V
L
S
A
R
T
L
360
361
R
G
L
N
M
A
L
V
E
F
S
T
V
E
S
A
I
C
A
L
E
A
L
Q
G
K
E
L
S
K
V
G
A
P
S
T
V
S
F
A
R
V
L
P
M
Y
E
Q
P
L
N
V
N
G
F
N
N
T
P
K
420
421
Q
P
L
L
Q
E
Q
L
N
H
G
V
L
N
Y
Q
L
Q
Q
S
L
Q
Q
P
E
L
Q
Q
Q
P
T
S
F
N
Q
P
N
L
T
Y
C
N
P
T
Q
N
L
S
H
L
Q
L
S
S
N
E
N
E
P
Y
480
481
P
F
P
L
P
P
P
S
L
S
D
S
K
K
D
I
L
H
T
I
S
S
F
K
L
E
Y
D
H
L
E
L
N
H
L
L
Q
N
A
L
K
N
K
G
V
S
D
T
N
Y
F
G
P
L
P
E
H
N
S
K
540
541
V
P
K
R
K
D
T
F
D
A
P
K
L
R
E
L
R
K
Q
F
D
S
N
S
L
S
T
I
E
M
E
Q
L
A
I
V
M
L
D
Q
L
P
E
L
S
S
D
Y
L
G
N
T
V
I
Q
K
L
F
E
N
600
601
S
S
N
I
I
R
D
I
M
L
R
K
C
N
K
Y
L
T
S
M
G
V
H
K
N
G
T
W
V
C
Q
K
I
I
K
M
A
N
T
P
R
Q
I
N
L
V
T
S
G
V
S
D
Y
C
T
P
L
F
N
D
660
661
Q
F
G
N
Y
V
I
Q
G
I
L
K
F
G
F
P
W
N
S
F
I
F
E
S
V
L
S
H
F
W
T
I
V
Q
N
R
Y
G
S
R
A
V
R
A
C
L
E
A
D
S
I
I
T
Q
C
Q
L
L
T
I
720
721
T
S
L
I
I
V
L
S
P
Y
L
A
T
D
T
N
G
T
L
L
I
T
W
L
L
D
T
C
T
L
P
N
K
N
L
I
L
C
D
K
L
V
N
K
N
L
V
K
L
C
C
H
K
L
G
S
L
T
V
L
780
781
K
I
L
N
L
R
G
G
E
E
E
A
L
S
K
N
K
I
I
H
A
I
F
D
G
P
I
S
S
D
S
I
L
F
Q
I
L
D
E
G
N
Y
G
P
T
F
I
Y
K
V
L
T
S
R
I
L
D
N
S
V
840
841
R
D
E
A
I
T
K
I
R
Q
L
I
L
N
S
N
I
N
L
Q
S
R
Q
L
L
E
E
V
G
L
S
S
A
G
I
S
P
K
Q
S
S
K
N
H
R
K
Q
H
P
Q
G
F
H
S
P
G
R
A
R
G
900
901
V
S
V
S
S
V
R
S
S
N
S
R
H
N
S
V
I
Q
M
N
N
A
G
P
T
P
A
L
N
F
N
P
A
P
M
S
E
I
N
S
Y
F
N
N
Q
Q
V
V
Y
S
G
N
Q
N
Q
N
Q
N
G
N
960
961
S
N
G
L
D
E
L
N
S
Q
F
D
S
F
R
I
A
N
G
T
N
L
S
L
P
I
V
N
L
P
N
V
S
N
N
N
N
N
Y
N
N
S
G
Y
S
S
Q
M
N
P
L
S
R
S
V
S
H
N
N
N
1020
1021
N
N
T
N
N
Y
N
N
N
D
N
D
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
S
N
N
S
N
N
N
N
N
N
D
T
S
L
Y
R
Y
R
S
Y
G
Y
1075
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0808
Peptide:
NYNNSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12221
UniProt Name:
PUF2_YEAST
Protein Name:
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Position:
998-1003
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-77.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.37
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0809 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
A
D
H
H
L
Q
Q
Q
Q
Q
Q
R
Q
Q
H
Q
Q
Q
Q
H
Q
Q
Q
Q
H
Q
H
Q
H
Q
Q
Q
Q
H
T
I
L
Q
N
V
S
N
T
N
N
I
G
S
D
S
L
A
S
Q
P
F
N
T
60
61
T
T
V
S
S
N
K
D
D
V
M
V
N
S
G
A
R
E
L
P
M
P
L
H
Q
Q
Q
Y
I
Y
P
Y
Y
Q
Y
T
S
N
N
S
N
N
N
N
V
T
A
G
N
N
M
S
A
S
P
I
V
H
N
N
120
121
S
N
N
S
N
N
S
N
I
S
A
S
D
Y
T
V
A
N
N
S
T
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
H
P
N
Q
F
T
A
A
A
N
M
N
S
N
A
A
A
A
A
Y
Y
S
180
181
F
P
T
A
N
M
P
I
P
Q
Q
D
Q
Q
Y
M
F
N
P
A
S
Y
I
S
H
Y
Y
S
A
V
N
S
N
N
N
G
N
N
A
A
N
N
G
S
N
N
S
S
H
S
A
P
A
P
A
P
G
P
P
H
240
241
H
H
H
H
H
S
N
T
H
N
N
L
N
N
G
G
A
V
N
T
N
N
A
P
Q
H
H
P
T
I
I
T
D
Q
F
Q
F
Q
L
Q
Q
N
P
S
P
N
L
N
L
N
I
N
P
A
Q
P
L
H
L
P
300
301
P
G
W
K
I
N
T
M
P
Q
P
R
P
T
T
A
P
N
H
P
P
A
P
V
P
S
S
N
P
V
A
S
N
L
V
P
A
P
S
S
D
H
K
Y
I
H
Q
C
Q
F
C
E
K
S
F
K
R
K
S
W
360
361
L
K
R
H
L
L
S
H
S
Q
Q
R
H
F
L
C
P
W
C
L
S
R
Q
K
R
K
D
N
L
L
Q
H
M
K
L
K
H
T
N
Y
L
L
D
E
L
K
K
N
N
I
I
F
N
Y
N
N
S
S
S
S
420
421
N
N
N
N
D
N
N
N
N
N
N
S
N
S
A
S
G
S
G
G
A
G
A
A
A
A
A
A
T
A
P
E
N
E
D
G
N
G
Y
D
T
N
I
K
T
L
I
N
D
G
V
L
N
K
D
D
V
K
R
V
480
481
L
N
N
L
I
V
S
H
N
K
490
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0809
Peptide:
NYNNSS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P54785
UniProt Name:
MOT3_YEAST
Protein Name:
Transcriptional activator/repressor MOT3
Position:
413-418
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-74.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.37
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0810 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0810
Peptide:
NYNTYR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-41.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.08
Aggregate Orientation (PASTA 2.0):
Antiparallel
