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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1351 to 1380 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1351
VTLHAT
6
amyloid
Zona pellucida sperm-binding protein 4
Q12836
C189A
FEBS Lett. 2016 Mar;590(5):619-30.
26879157
Waltz-DB 2.0
P-1352
VTLSQP
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1353
VTLWWG
6
amyloid
No
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
25133634
Waltz-DB 2.0
P-1354
VTQEFW
6
Non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1355
VTQVGF
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1356
VTSTFS
6
Amyloid
Apolipoprotein A-I (ApoA-I)
P02647
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1357
VTTGVT
6
Non-amyloid
Cell wall adhesin EAP1
G1UBC2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1358
VTTGVV
6
Non-amyloid
Caf1 hyphal wall protein 1
B2L5Z5
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1359
VTTVVS
6
Non-amyloid
Flocculin
E9P9G2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1360
VTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1361
VTVQAT
6
amyloid
No
Biopolymers. 2014 Nov;102(6):427-36.
25229478
Waltz-DB 2.0
P-1362
VVFFIC
6
Amyloid
Choline transporter-like protein 2 (Solute carrier family 44 member 2)
Q8IWA5
No
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-1363
VVIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624V
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1364
VVPQYG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1365
VVSTTV
6
Amyloid
Flocculin
E9P9G2
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1366
VVTSEE
6
Non-amyloid
Caf1 hyphal wall protein 1
B2L5Z5
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1367
VVVTSE
6
Non-amyloid
Caf1 hyphal wall protein 1
B2L5Z5
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1368
VVVVTS
6
Non-amyloid
Caf1 hyphal wall protein 1
B2L5Z5
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1369
VWIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624W
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1370
VYIMIG
6
amyloid
No
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
25133634
Waltz-DB 2.0
P-1371
VYIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Q624Y
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1372
VYSCEW
6
Non-amyloid
Alpha-galactosidase A
P06280
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1373
VYSRHP
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1374
VYSWEW
6
Non-amyloid
Alpha-galactosidase A
P06280
C202W
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1375
WATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38W
Switch Lab
SwitchLab
Waltz-DB 2.0
P-1376
WGMMGM
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1377
WGSASN
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1378
WIVIFF
6
Amyloid
Relaxin receptor 2 (G-protein coupled receptor 106)
Q8WXD0
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-1379
WNFGTQ
6
Non-amyloid
Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)
Q13231
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1380
WNFSTQ
6
Non-amyloid
Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)
Q13231
G102S
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-1351 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
W
L
L
R
C
V
L
L
C
V
S
L
S
L
A
V
S
G
Q
H
K
P
E
A
P
D
Y
S
S
V
L
H
C
G
P
W
S
F
Q
F
A
V
N
L
N
Q
E
A
T
S
P
P
V
L
I
A
W
D
N
60
61
Q
G
L
L
H
E
L
Q
N
D
S
D
C
G
T
W
I
R
K
G
P
G
S
S
V
V
L
E
A
T
Y
S
S
C
Y
V
T
E
W
D
S
H
Y
I
M
P
V
G
V
E
G
A
G
A
A
E
H
K
V
V
120
121
T
E
R
K
L
L
K
C
P
M
D
L
L
A
R
D
A
P
D
T
D
W
C
D
S
I
P
A
R
D
R
L
P
C
A
P
S
P
I
S
R
G
D
C
E
G
L
G
C
C
Y
S
S
E
E
V
N
S
C
Y
180
181
Y
G
N
T
V
T
L
H
C
T
R
E
G
H
F
S
I
A
V
S
R
N
V
T
S
P
P
L
L
L
D
S
V
R
L
A
L
R
N
D
S
A
C
N
P
V
M
A
T
Q
A
F
V
L
F
Q
F
P
F
T
240
241
S
C
G
T
T
R
Q
I
T
G
D
R
A
V
Y
E
N
E
L
V
A
T
R
D
V
K
N
G
S
R
G
S
V
T
R
D
S
I
F
R
L
H
V
S
C
S
Y
S
V
S
S
N
S
L
P
I
N
V
Q
V
300
301
F
T
L
P
P
P
F
P
E
T
Q
P
G
P
L
T
L
E
L
Q
I
A
K
D
K
N
Y
G
S
Y
Y
G
V
G
D
Y
P
V
V
K
L
L
R
D
P
I
Y
V
E
V
S
I
L
H
R
T
D
P
Y
L
360
361
G
L
L
L
Q
Q
C
W
A
T
P
S
T
D
P
L
S
Q
P
Q
W
P
I
L
V
K
G
C
P
Y
I
G
D
N
Y
Q
T
Q
L
I
P
V
Q
K
A
L
D
L
P
F
P
S
H
H
Q
R
F
S
I
F
420
421
T
F
S
F
V
N
P
T
V
E
K
Q
A
L
R
G
P
V
H
L
H
C
S
V
S
V
C
Q
P
A
E
T
P
S
C
V
V
T
C
P
D
L
S
R
R
R
N
F
D
N
S
S
Q
N
T
T
A
S
V
S
480
481
S
K
G
P
M
I
L
L
Q
A
T
K
D
P
P
E
K
L
R
V
P
V
D
S
K
V
L
W
V
A
G
L
S
G
T
L
I
L
G
A
L
L
V
S
Y
L
A
V
K
K
Q
K
S
C
P
D
Q
M
C
Q
540
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1351
Peptide:
VTLHAT
Length:
6
Classification:
amyloid
Mutation(s):
C189A
Structure(s):
No structures
Protein Information
UniProt ID:
Q12836
UniProt Name:
ZP4_HUMAN
Protein Name:
Zona pellucida sperm-binding protein 4
Position:
185-190
Literature
PMID:
26879157
Reference:
FEBS Lett. 2016 Mar;590(5):619-30.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.12
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.6
Area of the profile Above Threshold (AGGRESCAN):
0.52
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1352 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1352
Peptide:
VTLSQP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
105-110
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.3
Area of the profile Above Threshold (AGGRESCAN):
0.78
Best Energy Score (PASTA 2.0):
-2.18
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1353 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
V
T
L
W
W
G
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1353
Peptide:
VTLWWG
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
25133634
Reference:
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
52.6
Area of the profile Above Threshold (AGGRESCAN):
3.51
Best Energy Score (PASTA 2.0):
-4.64
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1354 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1354
Peptide:
VTQEFW
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
91-96
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.3
Area of the profile Above Threshold (AGGRESCAN):
0.15
Best Energy Score (PASTA 2.0):
-1.46
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1355 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1355
Peptide:
VTQVGF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
137-142
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.14
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.4
Area of the profile Above Threshold (AGGRESCAN):
0.95
Best Energy Score (PASTA 2.0):
-2.92
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1356 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1356
Peptide:
VTSTFS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
77-82
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.1
Area of the profile Above Threshold (AGGRESCAN):
0.77
Best Energy Score (PASTA 2.0):
-3.25
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1357 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
S
Q
I
L
P
L
A
G
A
I
S
V
A
S
G
F
W
I
P
D
F
S
N
K
Q
N
S
N
S
Y
P
G
Q
Y
K
G
K
G
G
Y
Q
D
D
C
G
D
D
Y
K
K
G
Y
K
S
K
T
Y
60
61
S
K
V
K
P
I
T
S
T
D
C
T
T
P
I
Q
P
T
G
T
T
T
G
Y
T
K
D
V
V
E
S
T
S
Y
T
T
D
T
A
Y
T
T
T
V
I
T
V
T
K
C
D
G
G
S
C
S
H
T
A
V
120
121
T
T
G
V
T
I
I
T
V
T
T
N
D
V
I
T
E
Y
T
T
Y
C
P
L
T
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
180
181
E
S
T
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
P
A
T
E
S
T
240
241
P
C
T
T
S
T
E
T
T
P
A
T
E
S
T
A
S
T
E
T
A
S
S
T
P
V
E
S
T
V
I
V
P
S
T
T
V
I
T
V
S
S
C
Y
E
D
K
C
S
V
S
S
V
T
T
G
V
V
T
I
300
301
S
S
E
E
T
I
Y
T
T
Y
C
P
I
T
S
S
I
T
I
P
V
P
N
T
S
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
360
361
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
420
421
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
A
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
P
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
480
481
A
P
G
T
P
V
E
S
Q
P
A
T
T
P
V
A
S
G
T
E
T
T
P
A
A
P
G
T
P
V
E
S
Q
P
V
I
P
G
T
E
T
T
P
A
A
P
G
T
P
G
T
E
A
T
P
V
T
T
Q
P
540
541
V
S
V
L
S
T
S
Q
V
V
T
A
S
G
E
F
S
T
V
T
A
H
S
T
S
I
V
A
S
C
P
E
G
G
C
V
P
E
G
Q
Q
T
E
T
S
P
S
V
P
T
N
G
P
E
V
E
A
S
S
S
600
601
V
L
S
I
P
V
S
S
V
T
T
S
T
I
A
S
S
S
E
T
S
V
P
P
A
Q
V
S
T
F
E
G
S
G
S
A
L
K
K
P
Y
Y
G
L
A
V
A
A
L
V
Y
F
M
653
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1357
Peptide:
VTTGVT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
G1UBC2
UniProt Name:
G1UBC2_CANAL
Protein Name:
Cell wall adhesin EAP1
Position:
120-125
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.04
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.5
Area of the profile Above Threshold (AGGRESCAN):
0.62
Best Energy Score (PASTA 2.0):
-2.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1358 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
L
S
T
A
Q
L
I
A
I
A
Y
Y
M
L
S
I
G
A
T
V
P
Q
V
D
G
Q
G
E
T
E
E
A
L
I
Q
K
R
S
Y
D
Y
Y
Q
E
P
C
D
D
Y
P
Q
Q
Q
Q
Q
E
E
P
60
61
C
D
Y
P
Q
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
120
121
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
Q
P
D
D
N
P
P
I
P
N
I
P
T
D
W
I
P
N
I
P
T
D
W
I
P
D
I
P
E
K
P
180
181
T
T
P
A
T
T
P
N
I
P
A
T
T
T
T
S
E
S
S
S
S
S
S
S
S
S
S
T
T
P
K
T
S
A
S
T
T
P
E
S
S
V
P
A
T
T
P
N
T
S
V
P
T
T
S
S
E
S
T
T
240
241
P
A
T
S
P
E
S
S
V
P
V
T
S
G
S
S
I
L
A
T
T
S
E
S
S
S
A
P
A
T
T
P
N
T
S
V
P
T
T
T
T
E
T
K
S
S
S
T
P
L
T
T
T
T
E
H
D
T
T
V
300
301
V
T
V
T
S
C
S
N
S
V
C
T
E
S
E
V
T
T
G
V
I
V
I
T
S
K
D
T
I
Y
T
T
Y
C
P
L
T
E
T
T
P
V
S
T
A
P
A
T
E
T
P
T
G
T
V
S
T
S
T
E
360
361
Q
S
T
T
V
I
T
V
T
S
C
S
E
S
S
C
T
E
S
E
V
T
T
G
V
V
V
V
T
S
E
E
T
V
Y
T
T
F
C
P
L
T
E
N
T
P
G
T
D
S
T
P
E
A
S
I
P
P
M
E
420
421
T
I
P
A
G
S
E
P
S
M
P
A
G
E
T
S
P
A
V
P
K
S
D
V
P
A
T
E
S
A
P
A
P
G
M
T
P
A
G
T
E
T
K
P
A
A
P
K
S
S
A
P
A
T
E
P
S
P
V
A
480
481
P
G
T
E
S
A
P
A
G
S
S
G
A
I
T
I
P
E
S
S
A
V
V
S
T
T
E
G
A
I
P
T
T
L
E
S
V
P
L
M
Q
P
S
A
N
Y
S
S
V
A
P
I
S
T
F
E
G
A
G
N
540
541
N
M
R
L
T
F
G
A
A
I
I
G
I
A
A
F
L
I
558
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1358
Peptide:
VTTGVV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B2L5Z5
UniProt Name:
B2L5Z5_9ASCO
Protein Name:
Caf1 hyphal wall protein 1
Position:
381-386
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
19.1
Area of the profile Above Threshold (AGGRESCAN):
1.58
Best Energy Score (PASTA 2.0):
-4.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1359 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
R
P
F
P
F
A
Y
L
V
L
S
L
L
F
Y
S
A
L
G
F
P
T
A
L
V
P
R
G
S
S
E
G
T
S
C
N
S
I
V
N
G
C
P
N
L
D
F
N
W
H
M
N
Q
Q
N
I
M
Q
60
61
Y
T
L
D
V
T
S
V
S
W
V
Q
D
N
T
Y
Q
I
T
I
H
V
K
G
E
E
N
I
D
L
K
Y
L
S
S
L
K
I
I
G
V
T
G
P
K
D
T
V
Q
L
Y
G
Y
D
E
N
T
D
W
I
120
121
D
N
P
L
V
S
R
C
D
E
N
T
Y
L
I
D
N
P
T
D
F
T
A
T
F
E
V
Y
A
T
Q
D
V
N
S
C
Q
V
W
M
P
N
F
Q
I
Q
F
E
Y
L
Q
G
S
A
A
E
Y
A
C
S
180
181
W
E
W
G
T
T
S
F
Y
L
S
T
G
C
D
N
Y
D
N
Q
G
Y
S
Q
T
D
F
P
G
F
Y
W
N
I
D
C
D
N
N
C
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
240
241
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
300
301
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
360
361
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
420
421
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
480
481
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
A
P
S
S
S
T
T
E
S
S
S
A
P
540
541
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
600
601
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
660
661
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
720
721
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
780
781
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
V
P
T
P
S
S
S
T
T
E
S
S
840
841
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
900
901
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
S
K
Y
P
G
S
Q
T
E
T
S
V
S
S
T
T
960
961
E
T
T
I
V
P
T
T
T
T
T
S
V
T
T
P
S
T
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
I
T
T
T
V
P
C
S
T
S
P
S
E
T
A
S
1020
1021
E
S
T
T
T
S
P
T
T
P
V
T
T
V
V
S
T
T
V
V
T
T
E
Y
S
T
S
T
K
P
G
G
E
I
T
T
T
F
V
T
K
N
I
P
T
T
Y
L
T
T
I
A
P
T
P
S
V
T
T
V
1080
1081
T
N
F
T
P
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
V
T
T
T
V
P
C
S
T
G
T
G
E
Y
T
T
E
A
T
T
P
V
T
T
A
V
T
T
T
1140
1141
V
V
T
T
E
S
S
T
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
V
P
T
T
Y
V
T
T
L
A
P
S
A
P
V
T
P
A
T
S
A
V
P
T
T
I
T
T
T
E
C
S
A
A
T
N
1200
1201
A
A
G
E
T
T
S
V
C
S
A
K
T
I
V
S
S
A
S
A
G
E
N
T
T
P
V
T
T
A
I
P
T
T
V
V
T
T
E
S
S
V
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
I
P
1260
1261
T
T
Y
I
T
T
L
I
P
G
S
N
G
A
K
N
Y
E
T
V
A
T
A
T
N
P
I
S
I
K
T
T
S
Q
L
A
T
T
A
S
A
S
S
M
A
P
V
V
T
S
P
S
L
T
G
P
L
Q
S
A
1320
1321
S
G
S
A
V
A
T
Y
S
V
P
S
I
S
S
T
Y
Q
G
A
A
N
I
K
V
L
G
N
F
M
W
L
L
L
A
L
P
V
V
F
1360
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1359
Peptide:
VTTVVS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
E9P9G2
UniProt Name:
E9P9G2_YEASX
Protein Name:
Flocculin
Position:
1031-1036
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
42.8
Area of the profile Above Threshold (AGGRESCAN):
2.82
Best Energy Score (PASTA 2.0):
-6.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1360 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1360
Peptide:
VTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
1.02
Tango:
1.18
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
74.3
Area of the profile Above Threshold (AGGRESCAN):
4.91
Best Energy Score (PASTA 2.0):
-8.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1361 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
V
T
V
Q
A
T
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1361
Peptide:
VTVQAT
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
25229478
Reference:
Biopolymers. 2014 Nov;102(6):427-36.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.9
Area of the profile Above Threshold (AGGRESCAN):
0.53
Best Energy Score (PASTA 2.0):
-2.66
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1362 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
V
V
F
F
I
C
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1362
Peptide:
VVFFIC
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8IWA5
UniProt Name:
CTL2_HUMAN
Protein Name:
Choline transporter-like protein 2 (Solute carrier family 44 member 2)
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.09
Tango:
210.48
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
119.6
Area of the profile Above Threshold (AGGRESCAN):
7.82
Best Energy Score (PASTA 2.0):
-7.83
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1363 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1363
Peptide:
VVIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624V
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.96
Tango:
108.74
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
93.6
Area of the profile Above Threshold (AGGRESCAN):
6.24
Best Energy Score (PASTA 2.0):
-8.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1364 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1364
Peptide:
VVPQYG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
22-27
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.1
Area of the profile Above Threshold (AGGRESCAN):
0.2
Best Energy Score (PASTA 2.0):
0.85
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1365 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
R
P
F
P
F
A
Y
L
V
L
S
L
L
F
Y
S
A
L
G
F
P
T
A
L
V
P
R
G
S
S
E
G
T
S
C
N
S
I
V
N
G
C
P
N
L
D
F
N
W
H
M
N
Q
Q
N
I
M
Q
60
61
Y
T
L
D
V
T
S
V
S
W
V
Q
D
N
T
Y
Q
I
T
I
H
V
K
G
E
E
N
I
D
L
K
Y
L
S
S
L
K
I
I
G
V
T
G
P
K
D
T
V
Q
L
Y
G
Y
D
E
N
T
D
W
I
120
121
D
N
P
L
V
S
R
C
D
E
N
T
Y
L
I
D
N
P
T
D
F
T
A
T
F
E
V
Y
A
T
Q
D
V
N
S
C
Q
V
W
M
P
N
F
Q
I
Q
F
E
Y
L
Q
G
S
A
A
E
Y
A
C
S
180
181
W
E
W
G
T
T
S
F
Y
L
S
T
G
C
D
N
Y
D
N
Q
G
Y
S
Q
T
D
F
P
G
F
Y
W
N
I
D
C
D
N
N
C
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
240
241
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
300
301
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
360
361
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
420
421
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
480
481
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
A
P
S
S
S
T
T
E
S
S
S
A
P
540
541
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
600
601
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
A
P
T
660
661
P
S
S
S
T
T
E
S
S
S
A
P
A
T
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
T
S
S
T
T
720
721
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
C
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
P
T
P
S
S
S
T
T
780
781
E
S
S
S
A
P
V
T
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
V
P
T
P
S
S
S
T
T
E
S
S
840
841
S
A
P
A
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
T
P
F
S
S
S
T
E
S
S
S
V
P
900
901
V
P
T
P
S
S
S
T
T
E
S
S
S
A
P
V
S
S
S
T
T
E
S
S
V
A
P
V
P
T
P
S
S
S
S
N
I
T
S
S
A
P
S
S
S
K
Y
P
G
S
Q
T
E
T
S
V
S
S
T
T
960
961
E
T
T
I
V
P
T
T
T
T
T
S
V
T
T
P
S
T
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
I
T
T
T
V
P
C
S
T
S
P
S
E
T
A
S
1020
1021
E
S
T
T
T
S
P
T
T
P
V
T
T
V
V
S
T
T
V
V
T
T
E
Y
S
T
S
T
K
P
G
G
E
I
T
T
T
F
V
T
K
N
I
P
T
T
Y
L
T
T
I
A
P
T
P
S
V
T
T
V
1080
1081
T
N
F
T
P
T
T
I
T
T
T
V
C
S
T
G
T
N
S
A
G
E
T
T
S
G
C
S
P
K
T
V
T
T
T
V
P
C
S
T
G
T
G
E
Y
T
T
E
A
T
T
P
V
T
T
A
V
T
T
T
1140
1141
V
V
T
T
E
S
S
T
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
V
P
T
T
Y
V
T
T
L
A
P
S
A
P
V
T
P
A
T
S
A
V
P
T
T
I
T
T
T
E
C
S
A
A
T
N
1200
1201
A
A
G
E
T
T
S
V
C
S
A
K
T
I
V
S
S
A
S
A
G
E
N
T
T
P
V
T
T
A
I
P
T
T
V
V
T
T
E
S
S
V
G
T
N
S
A
G
E
T
T
T
G
Y
T
T
K
S
I
P
1260
1261
T
T
Y
I
T
T
L
I
P
G
S
N
G
A
K
N
Y
E
T
V
A
T
A
T
N
P
I
S
I
K
T
T
S
Q
L
A
T
T
A
S
A
S
S
M
A
P
V
V
T
S
P
S
L
T
G
P
L
Q
S
A
1320
1321
S
G
S
A
V
A
T
Y
S
V
P
S
I
S
S
T
Y
Q
G
A
A
N
I
K
V
L
G
N
F
M
W
L
L
L
A
L
P
V
V
F
1360
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1365
Peptide:
VVSTTV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
E9P9G2
UniProt Name:
E9P9G2_YEASX
Protein Name:
Flocculin
Position:
1034-1039
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.9
Area of the profile Above Threshold (AGGRESCAN):
1.68
Best Energy Score (PASTA 2.0):
-5.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1366 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
L
S
T
A
Q
L
I
A
I
A
Y
Y
M
L
S
I
G
A
T
V
P
Q
V
D
G
Q
G
E
T
E
E
A
L
I
Q
K
R
S
Y
D
Y
Y
Q
E
P
C
D
D
Y
P
Q
Q
Q
Q
Q
E
E
P
60
61
C
D
Y
P
Q
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
120
121
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
Q
P
D
D
N
P
P
I
P
N
I
P
T
D
W
I
P
N
I
P
T
D
W
I
P
D
I
P
E
K
P
180
181
T
T
P
A
T
T
P
N
I
P
A
T
T
T
T
S
E
S
S
S
S
S
S
S
S
S
S
T
T
P
K
T
S
A
S
T
T
P
E
S
S
V
P
A
T
T
P
N
T
S
V
P
T
T
S
S
E
S
T
T
240
241
P
A
T
S
P
E
S
S
V
P
V
T
S
G
S
S
I
L
A
T
T
S
E
S
S
S
A
P
A
T
T
P
N
T
S
V
P
T
T
T
T
E
T
K
S
S
S
T
P
L
T
T
T
T
E
H
D
T
T
V
300
301
V
T
V
T
S
C
S
N
S
V
C
T
E
S
E
V
T
T
G
V
I
V
I
T
S
K
D
T
I
Y
T
T
Y
C
P
L
T
E
T
T
P
V
S
T
A
P
A
T
E
T
P
T
G
T
V
S
T
S
T
E
360
361
Q
S
T
T
V
I
T
V
T
S
C
S
E
S
S
C
T
E
S
E
V
T
T
G
V
V
V
V
T
S
E
E
T
V
Y
T
T
F
C
P
L
T
E
N
T
P
G
T
D
S
T
P
E
A
S
I
P
P
M
E
420
421
T
I
P
A
G
S
E
P
S
M
P
A
G
E
T
S
P
A
V
P
K
S
D
V
P
A
T
E
S
A
P
A
P
G
M
T
P
A
G
T
E
T
K
P
A
A
P
K
S
S
A
P
A
T
E
P
S
P
V
A
480
481
P
G
T
E
S
A
P
A
G
S
S
G
A
I
T
I
P
E
S
S
A
V
V
S
T
T
E
G
A
I
P
T
T
L
E
S
V
P
L
M
Q
P
S
A
N
Y
S
S
V
A
P
I
S
T
F
E
G
A
G
N
540
541
N
M
R
L
T
F
G
A
A
I
I
G
I
A
A
F
L
I
558
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1366
Peptide:
VVTSEE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B2L5Z5
UniProt Name:
B2L5Z5_9ASCO
Protein Name:
Caf1 hyphal wall protein 1
Position:
387-392
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-22.9
Area of the profile Above Threshold (AGGRESCAN):
0.89
Best Energy Score (PASTA 2.0):
-3.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1367 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
L
S
T
A
Q
L
I
A
I
A
Y
Y
M
L
S
I
G
A
T
V
P
Q
V
D
G
Q
G
E
T
E
E
A
L
I
Q
K
R
S
Y
D
Y
Y
Q
E
P
C
D
D
Y
P
Q
Q
Q
Q
Q
E
E
P
60
61
C
D
Y
P
Q
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
120
121
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
Q
P
D
D
N
P
P
I
P
N
I
P
T
D
W
I
P
N
I
P
T
D
W
I
P
D
I
P
E
K
P
180
181
T
T
P
A
T
T
P
N
I
P
A
T
T
T
T
S
E
S
S
S
S
S
S
S
S
S
S
T
T
P
K
T
S
A
S
T
T
P
E
S
S
V
P
A
T
T
P
N
T
S
V
P
T
T
S
S
E
S
T
T
240
241
P
A
T
S
P
E
S
S
V
P
V
T
S
G
S
S
I
L
A
T
T
S
E
S
S
S
A
P
A
T
T
P
N
T
S
V
P
T
T
T
T
E
T
K
S
S
S
T
P
L
T
T
T
T
E
H
D
T
T
V
300
301
V
T
V
T
S
C
S
N
S
V
C
T
E
S
E
V
T
T
G
V
I
V
I
T
S
K
D
T
I
Y
T
T
Y
C
P
L
T
E
T
T
P
V
S
T
A
P
A
T
E
T
P
T
G
T
V
S
T
S
T
E
360
361
Q
S
T
T
V
I
T
V
T
S
C
S
E
S
S
C
T
E
S
E
V
T
T
G
V
V
V
V
T
S
E
E
T
V
Y
T
T
F
C
P
L
T
E
N
T
P
G
T
D
S
T
P
E
A
S
I
P
P
M
E
420
421
T
I
P
A
G
S
E
P
S
M
P
A
G
E
T
S
P
A
V
P
K
S
D
V
P
A
T
E
S
A
P
A
P
G
M
T
P
A
G
T
E
T
K
P
A
A
P
K
S
S
A
P
A
T
E
P
S
P
V
A
480
481
P
G
T
E
S
A
P
A
G
S
S
G
A
I
T
I
P
E
S
S
A
V
V
S
T
T
E
G
A
I
P
T
T
L
E
S
V
P
L
M
Q
P
S
A
N
Y
S
S
V
A
P
I
S
T
F
E
G
A
G
N
540
541
N
M
R
L
T
F
G
A
A
I
I
G
I
A
A
F
L
I
558
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1367
Peptide:
VVVTSE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B2L5Z5
UniProt Name:
B2L5Z5_9ASCO
Protein Name:
Caf1 hyphal wall protein 1
Position:
386-391
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
29.8
Area of the profile Above Threshold (AGGRESCAN):
2.72
Best Energy Score (PASTA 2.0):
-6.09
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1368 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
L
S
T
A
Q
L
I
A
I
A
Y
Y
M
L
S
I
G
A
T
V
P
Q
V
D
G
Q
G
E
T
E
E
A
L
I
Q
K
R
S
Y
D
Y
Y
Q
E
P
C
D
D
Y
P
Q
Q
Q
Q
Q
E
E
P
60
61
C
D
Y
P
Q
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
Y
P
Q
Q
P
Q
E
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
120
121
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
I
P
C
D
N
P
P
Q
P
D
Q
P
D
D
N
P
P
I
P
N
I
P
T
D
W
I
P
N
I
P
T
D
W
I
P
D
I
P
E
K
P
180
181
T
T
P
A
T
T
P
N
I
P
A
T
T
T
T
S
E
S
S
S
S
S
S
S
S
S
S
T
T
P
K
T
S
A
S
T
T
P
E
S
S
V
P
A
T
T
P
N
T
S
V
P
T
T
S
S
E
S
T
T
240
241
P
A
T
S
P
E
S
S
V
P
V
T
S
G
S
S
I
L
A
T
T
S
E
S
S
S
A
P
A
T
T
P
N
T
S
V
P
T
T
T
T
E
T
K
S
S
S
T
P
L
T
T
T
T
E
H
D
T
T
V
300
301
V
T
V
T
S
C
S
N
S
V
C
T
E
S
E
V
T
T
G
V
I
V
I
T
S
K
D
T
I
Y
T
T
Y
C
P
L
T
E
T
T
P
V
S
T
A
P
A
T
E
T
P
T
G
T
V
S
T
S
T
E
360
361
Q
S
T
T
V
I
T
V
T
S
C
S
E
S
S
C
T
E
S
E
V
T
T
G
V
V
V
V
T
S
E
E
T
V
Y
T
T
F
C
P
L
T
E
N
T
P
G
T
D
S
T
P
E
A
S
I
P
P
M
E
420
421
T
I
P
A
G
S
E
P
S
M
P
A
G
E
T
S
P
A
V
P
K
S
D
V
P
A
T
E
S
A
P
A
P
G
M
T
P
A
G
T
E
T
K
P
A
A
P
K
S
S
A
P
A
T
E
P
S
P
V
A
480
481
P
G
T
E
S
A
P
A
G
S
S
G
A
I
T
I
P
E
S
S
A
V
V
S
T
T
E
G
A
I
P
T
T
L
E
S
V
P
L
M
Q
P
S
A
N
Y
S
S
V
A
P
I
S
T
F
E
G
A
G
N
540
541
N
M
R
L
T
F
G
A
A
I
I
G
I
A
A
F
L
I
558
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1368
Peptide:
VVVVTS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B2L5Z5
UniProt Name:
B2L5Z5_9ASCO
Protein Name:
Caf1 hyphal wall protein 1
Position:
385-390
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.95
Tango:
9.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
77.8
Area of the profile Above Threshold (AGGRESCAN):
5.28
Best Energy Score (PASTA 2.0):
-8.1
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1369 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1369
Peptide:
VWIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624W
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.94
Tango:
81.86
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
86.2
Area of the profile Above Threshold (AGGRESCAN):
5.74
Best Energy Score (PASTA 2.0):
-7.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1370 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
V
Y
I
M
I
G
6
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1370
Peptide:
VYIMIG
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
25133634
Reference:
ACS Chem Neurosci. 2014 Oct 15;5(10):972-81.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.99
Tango:
4.63
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
86.9
Area of the profile Above Threshold (AGGRESCAN):
5.73
Best Energy Score (PASTA 2.0):
-6.56
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1371 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1371
Peptide:
VYIVYK
Length:
6
Classification:
amyloid
Mutation(s):
Q624Y
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.86
Tango:
49.72
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
87.8
Area of the profile Above Threshold (AGGRESCAN):
5.85
Best Energy Score (PASTA 2.0):
-6.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1372 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
R
N
P
E
L
H
L
G
C
A
L
A
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
A
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
W
E
R
F
M
C
N
L
D
C
Q
E
E
P
60
61
D
S
C
I
S
E
K
L
F
M
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
C
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
P
Q
R
F
P
H
G
I
R
Q
L
120
121
A
N
Y
V
H
S
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
A
D
W
G
V
D
L
L
K
F
D
G
C
Y
C
D
S
L
E
N
L
180
181
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
M
W
P
F
Q
K
P
N
Y
T
E
I
R
Q
Y
C
N
H
W
R
N
F
A
D
I
D
D
S
W
K
S
I
K
240
241
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
D
V
A
G
P
G
G
W
N
D
P
D
M
L
V
I
G
N
F
G
L
S
W
N
Q
Q
V
T
Q
M
A
L
W
A
I
M
A
A
P
L
F
M
S
N
D
L
300
301
R
H
I
S
P
Q
A
K
A
L
L
Q
D
K
D
V
I
A
I
N
Q
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
F
E
V
W
E
R
P
L
S
G
L
A
W
A
V
A
M
I
N
R
Q
E
I
G
360
361
G
P
R
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
N
P
A
C
F
I
T
Q
L
L
P
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
T
420
421
M
Q
M
S
L
K
D
L
L
429
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1372
Peptide:
VYSCEW
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06280
UniProt Name:
AGAL_HUMAN
Protein Name:
Alpha-galactosidase A
Position:
199-204
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.93
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
11.1
Area of the profile Above Threshold (AGGRESCAN):
1.36
Best Energy Score (PASTA 2.0):
-2.11
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1373 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1373
Peptide:
VYSRHP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
29-34
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-34.5
Area of the profile Above Threshold (AGGRESCAN):
0.06
Best Energy Score (PASTA 2.0):
-1.24
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1374 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
R
N
P
E
L
H
L
G
C
A
L
A
L
R
F
L
A
L
V
S
W
D
I
P
G
A
R
A
L
D
N
G
L
A
R
T
P
T
M
G
W
L
H
W
E
R
F
M
C
N
L
D
C
Q
E
E
P
60
61
D
S
C
I
S
E
K
L
F
M
E
M
A
E
L
M
V
S
E
G
W
K
D
A
G
Y
E
Y
L
C
I
D
D
C
W
M
A
P
Q
R
D
S
E
G
R
L
Q
A
D
P
Q
R
F
P
H
G
I
R
Q
L
120
121
A
N
Y
V
H
S
K
G
L
K
L
G
I
Y
A
D
V
G
N
K
T
C
A
G
F
P
G
S
F
G
Y
Y
D
I
D
A
Q
T
F
A
D
W
G
V
D
L
L
K
F
D
G
C
Y
C
D
S
L
E
N
L
180
181
A
D
G
Y
K
H
M
S
L
A
L
N
R
T
G
R
S
I
V
Y
S
C
E
W
P
L
Y
M
W
P
F
Q
K
P
N
Y
T
E
I
R
Q
Y
C
N
H
W
R
N
F
A
D
I
D
D
S
W
K
S
I
K
240
241
S
I
L
D
W
T
S
F
N
Q
E
R
I
V
D
V
A
G
P
G
G
W
N
D
P
D
M
L
V
I
G
N
F
G
L
S
W
N
Q
Q
V
T
Q
M
A
L
W
A
I
M
A
A
P
L
F
M
S
N
D
L
300
301
R
H
I
S
P
Q
A
K
A
L
L
Q
D
K
D
V
I
A
I
N
Q
D
P
L
G
K
Q
G
Y
Q
L
R
Q
G
D
N
F
E
V
W
E
R
P
L
S
G
L
A
W
A
V
A
M
I
N
R
Q
E
I
G
360
361
G
P
R
S
Y
T
I
A
V
A
S
L
G
K
G
V
A
C
N
P
A
C
F
I
T
Q
L
L
P
V
K
R
K
L
G
F
Y
E
W
T
S
R
L
R
S
H
I
N
P
T
G
T
V
L
L
Q
L
E
N
T
420
421
M
Q
M
S
L
K
D
L
L
429
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1374
Peptide:
VYSWEW
Length:
6
Classification:
Non-amyloid
Mutation(s):
C202W
Structure(s):
No structures
Protein Information
UniProt ID:
P06280
UniProt Name:
AGAL_HUMAN
Protein Name:
Alpha-galactosidase A
Position:
199-204
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.81
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
19.7
Area of the profile Above Threshold (AGGRESCAN):
1.75
Best Energy Score (PASTA 2.0):
-2.67
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1375 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1375
Peptide:
WATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38W
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.76
Tango:
2.69
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
51.9
Area of the profile Above Threshold (AGGRESCAN):
3.33
Best Energy Score (PASTA 2.0):
-4.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1376 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1376
Peptide:
WGMMGM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
334-339
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.34
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.5
Area of the profile Above Threshold (AGGRESCAN):
1.61
Best Energy Score (PASTA 2.0):
-0.21
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1377 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1377
Peptide:
WGSASN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
385-390
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.6
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1378 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
I
V
F
L
V
F
K
H
L
F
S
L
R
L
I
T
M
F
F
L
L
H
F
I
V
L
I
N
V
K
D
F
A
L
T
Q
G
S
M
I
T
P
S
C
Q
K
G
Y
F
P
C
G
N
L
T
K
C
L
P
60
61
R
A
F
H
C
D
G
K
D
D
C
G
N
G
A
D
E
E
N
C
G
D
T
S
G
W
A
T
I
F
G
T
V
H
G
N
A
N
S
V
A
L
T
Q
E
C
F
L
K
Q
Y
P
Q
C
C
D
C
K
E
T
120
121
E
L
E
C
V
N
G
D
L
K
S
V
P
M
I
S
N
N
V
T
L
L
S
L
K
K
N
K
I
H
S
L
P
D
K
V
F
I
K
Y
T
K
L
K
K
I
F
L
Q
H
N
C
I
R
H
I
S
R
K
A
180
181
F
F
G
L
C
N
L
Q
I
L
Y
L
N
H
N
C
I
T
T
L
R
P
G
I
F
K
D
L
H
Q
L
T
W
L
I
L
D
D
N
P
I
T
R
I
S
Q
R
L
F
T
G
L
N
S
L
F
F
L
S
M
240
241
V
N
N
Y
L
E
A
L
P
K
Q
M
C
A
Q
M
P
Q
L
N
W
V
D
L
E
G
N
R
I
K
Y
L
T
N
S
T
F
L
S
C
D
S
L
T
V
L
F
L
P
R
N
Q
I
G
F
V
P
E
K
T
300
301
F
S
S
L
K
N
L
G
E
L
D
L
S
S
N
T
I
T
E
L
S
P
H
L
F
K
D
L
K
L
L
Q
K
L
N
L
S
S
N
P
L
M
Y
L
H
K
N
Q
F
E
S
L
K
Q
L
Q
S
L
D
L
360
361
E
R
I
E
I
P
N
I
N
T
R
M
F
Q
P
M
K
N
L
S
H
I
Y
F
K
N
F
R
Y
C
S
Y
A
P
H
V
R
I
C
M
P
L
T
D
G
I
S
S
F
E
D
L
L
A
N
N
I
L
R
I
420
421
F
V
W
V
I
A
F
I
T
C
F
G
N
L
F
V
I
G
M
R
S
F
I
K
A
E
N
T
T
H
A
M
S
I
K
I
L
C
C
A
D
C
L
M
G
V
Y
L
F
F
V
G
I
F
D
I
K
Y
R
G
480
481
Q
Y
Q
K
Y
A
L
L
W
M
E
S
V
Q
C
R
L
M
G
F
L
A
M
L
S
T
E
V
S
V
L
L
L
T
Y
L
T
L
E
K
F
L
V
I
V
F
P
F
S
N
I
R
P
G
K
R
Q
T
S
V
540
541
I
L
I
C
I
W
M
A
G
F
L
I
A
V
I
P
F
W
N
K
D
Y
F
G
N
F
Y
G
K
N
G
V
C
F
P
L
Y
Y
D
Q
T
E
D
I
G
S
K
G
Y
S
L
G
I
F
L
G
V
N
L
L
600
601
A
F
L
I
I
V
F
S
Y
I
T
M
F
C
S
I
Q
K
T
A
L
Q
T
T
E
V
R
N
C
F
G
R
E
V
A
V
A
N
R
F
F
F
I
V
F
S
D
A
I
C
W
I
P
V
F
V
V
K
I
L
660
661
S
L
F
R
V
E
I
P
D
T
M
T
S
W
I
V
I
F
F
L
P
V
N
S
A
L
N
P
I
L
Y
T
L
T
T
N
F
F
K
D
K
L
K
Q
L
L
H
K
H
Q
R
K
S
I
F
K
I
K
K
K
720
721
S
L
S
T
S
I
V
W
I
E
D
S
S
S
L
K
L
G
V
L
N
K
I
T
L
G
D
S
I
M
K
P
V
S
754
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1378
Peptide:
WIVIFF
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8WXD0
UniProt Name:
RXFP2_HUMAN
Protein Name:
Relaxin receptor 2 (G-protein coupled receptor 106)
Position:
674-679
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.07
Tango:
360.79
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
125.8
Area of the profile Above Threshold (AGGRESCAN):
8.15
Best Energy Score (PASTA 2.0):
-8.63
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1379 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
R
S
V
A
W
A
G
F
M
V
L
L
M
I
P
W
G
S
A
A
K
L
V
C
Y
F
T
N
W
A
Q
Y
R
Q
G
E
A
R
F
L
P
K
D
L
D
P
S
L
C
T
H
L
I
Y
A
F
A
G
60
61
M
T
N
H
Q
L
S
T
T
E
W
N
D
E
T
L
Y
Q
E
F
N
G
L
K
K
M
N
P
K
L
K
T
L
L
A
I
G
G
W
N
F
G
T
Q
K
F
T
D
M
V
A
T
A
N
N
R
Q
T
F
V
120
121
N
S
A
I
R
F
L
R
K
Y
S
F
D
G
L
D
L
D
W
E
Y
P
G
S
Q
G
S
P
A
V
D
K
E
R
F
T
T
L
V
Q
D
L
A
N
A
F
Q
Q
E
A
Q
T
S
G
K
E
R
L
L
L
180
181
S
A
A
V
P
A
G
Q
T
Y
V
D
A
G
Y
E
V
D
K
I
A
Q
N
L
D
F
V
N
L
M
A
Y
D
F
H
G
S
W
E
K
V
T
G
H
N
S
P
L
Y
K
R
Q
E
E
S
G
A
A
A
S
240
241
L
N
V
D
A
A
V
Q
Q
W
L
Q
K
G
T
P
A
S
K
L
I
L
G
M
P
T
Y
G
R
S
F
T
L
A
S
S
S
D
T
R
V
G
A
P
A
T
G
S
G
T
P
G
P
F
T
K
E
G
G
M
300
301
L
A
Y
Y
E
V
C
S
W
K
G
A
T
K
Q
R
I
Q
D
Q
K
V
P
Y
I
F
R
D
N
Q
W
V
G
F
D
D
V
E
S
F
K
T
K
V
S
Y
L
K
Q
K
G
L
G
G
A
M
V
W
A
L
360
361
D
L
D
D
F
A
G
F
S
C
N
Q
G
R
Y
P
L
I
Q
T
L
R
Q
E
L
S
L
P
Y
L
P
S
G
T
P
E
L
E
V
P
K
P
G
Q
P
S
E
P
E
H
G
P
S
P
G
Q
D
T
F
C
420
421
Q
G
K
A
D
G
L
Y
P
N
P
R
E
R
S
S
F
Y
S
C
A
A
G
R
L
F
Q
Q
S
C
P
T
G
L
V
F
S
N
S
C
K
C
C
T
W
N
466
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1379
Peptide:
WNFGTQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13231
UniProt Name:
CHIT1_HUMAN
Protein Name:
Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)
Position:
99-104
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.17
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.1
Area of the profile Above Threshold (AGGRESCAN):
0.18
Best Energy Score (PASTA 2.0):
-0.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1380 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
R
S
V
A
W
A
G
F
M
V
L
L
M
I
P
W
G
S
A
A
K
L
V
C
Y
F
T
N
W
A
Q
Y
R
Q
G
E
A
R
F
L
P
K
D
L
D
P
S
L
C
T
H
L
I
Y
A
F
A
G
60
61
M
T
N
H
Q
L
S
T
T
E
W
N
D
E
T
L
Y
Q
E
F
N
G
L
K
K
M
N
P
K
L
K
T
L
L
A
I
G
G
W
N
F
G
T
Q
K
F
T
D
M
V
A
T
A
N
N
R
Q
T
F
V
120
121
N
S
A
I
R
F
L
R
K
Y
S
F
D
G
L
D
L
D
W
E
Y
P
G
S
Q
G
S
P
A
V
D
K
E
R
F
T
T
L
V
Q
D
L
A
N
A
F
Q
Q
E
A
Q
T
S
G
K
E
R
L
L
L
180
181
S
A
A
V
P
A
G
Q
T
Y
V
D
A
G
Y
E
V
D
K
I
A
Q
N
L
D
F
V
N
L
M
A
Y
D
F
H
G
S
W
E
K
V
T
G
H
N
S
P
L
Y
K
R
Q
E
E
S
G
A
A
A
S
240
241
L
N
V
D
A
A
V
Q
Q
W
L
Q
K
G
T
P
A
S
K
L
I
L
G
M
P
T
Y
G
R
S
F
T
L
A
S
S
S
D
T
R
V
G
A
P
A
T
G
S
G
T
P
G
P
F
T
K
E
G
G
M
300
301
L
A
Y
Y
E
V
C
S
W
K
G
A
T
K
Q
R
I
Q
D
Q
K
V
P
Y
I
F
R
D
N
Q
W
V
G
F
D
D
V
E
S
F
K
T
K
V
S
Y
L
K
Q
K
G
L
G
G
A
M
V
W
A
L
360
361
D
L
D
D
F
A
G
F
S
C
N
Q
G
R
Y
P
L
I
Q
T
L
R
Q
E
L
S
L
P
Y
L
P
S
G
T
P
E
L
E
V
P
K
P
G
Q
P
S
E
P
E
H
G
P
S
P
G
Q
D
T
F
C
420
421
Q
G
K
A
D
G
L
Y
P
N
P
R
E
R
S
S
F
Y
S
C
A
A
G
R
L
F
Q
Q
S
C
P
T
G
L
V
F
S
N
S
C
K
C
C
T
W
N
466
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1380
Peptide:
WNFSTQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
G102S
Structure(s):
No structures
Protein Information
UniProt ID:
Q13231
UniProt Name:
CHIT1_HUMAN
Protein Name:
Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)
Position:
99-104
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.07
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-10.3
Area of the profile Above Threshold (AGGRESCAN):
0.23
Best Energy Score (PASTA 2.0):
-1.18
Aggregate Orientation (PASTA 2.0):
Parallel
