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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1831 to 1860 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1831
AYVKKLDSGTGKELVLAL
18
Non-amyloid
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Q13813
J Mol Biol. 1996 Jan 26;255(3):507-21.
8568894
AmyLoad
P-1832
DFVIFLDVKHFSPEDLTV
18
Amyloid
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
P02489
K70D
Biochemistry. 2008 Mar 4;47(9):2961-7.
18232642
CPAD
P-1833
EESEFEPFIEEISTKISY
18
Non-amyloid
Flavodoxin
P00322
G79Y
J Mol Biol. 1995 Apr 7;247(4):648-69.
7723021
AmyLoad
P-1834
EQVTNVGGAVVTGVTAVA
18
Amyloid
Alpha-synuclein
P37840
No
Eur J Biochem. 2000 Apr;267(8):2186-94.
10759841
CPAD, AmyLoad
P-1835
FSMLVAAIQSAGLTETLN
18
Amyloid
FEBS Lett. 2007 Jan 23;581(2):241-7.
17207483
CPAD
P-1836
FVIFLDVKHFSPEDLTVK
18
Amyloid
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
P02489
No
Biochemistry. 2008 Mar 4;47(9):2961-7.
18232642
CPAD
P-1837
FVNVEAVKAFLEAHGIAY
18
Amyloid
Carboxypeptidase A2
P48052
Q75E, V79A, S83A, Q84H
Protein Sci. 2000 Sep;9(9):1700-8.
11045616
CPAD, AmyLoad
P-1838
FVNVQAVKVFLESQGIAY
18
Amyloid
Carboxypeptidase A2
P48052
No
Protein Sci. 2000 Sep;9(9):1700-8.
11045616
CPAD, AmyLoad
P-1839
GNLPFLGTAGVAGEFPTA
18
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1840
GSTTTQLYTDCTEKLRPE
18
Amyloid
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3)
Q15582
R124C
Eur J Biochem. 2002 Nov;269(21):5149-56.
12392546
CPAD
P-1841
GSTTTQLYTDRTEKLRPE
18
Amyloid
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3)
Q15582
No
Eur J Biochem. 2002 Nov;269(21):5149-56.
12392546
CPAD
P-1842
GVGKSALTIQLIQNHFVY
18
Amyloid
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
CPAD, AmyLoad
P-1843
GWEIPEPYVWDESFRVFY
18
Non-amyloid
Myohemerythrin (MHr)
P02247
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
AmyLoad
P-1844
IKYLEFISQAIIHVLHSR
18
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1845
KFVIFLDVKHFSPEDLTV
18
Amyloid
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
P02489
No
Biochemistry. 2008 Mar 4;47(9):2961-7.
18232642
CPAD
P-1846
MPEEELLNAPGETYVVTL
18
Amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
CPAD, AmyLoad
P-1847
NGERIEKVEHSDLSFSKD
18
Non-amyloid
Beta-2-microglobulin
P61769
No
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
12488093
AmyLoad
P-1848
PVTQEFWDNLEKETEGLR
18
Non-amyloid
Apolipoprotein A-I
P02647
No
FEBS Lett. 2014 Jan 31;588(3):389-94
24316228
CPAD
P-1849
RGGRLCYCRRRFCVCVGR
18
Amyloid
Protegrin-1 (PG-1) (Neutrophil peptide 1)
P32194
No
Biophys J. 2011 Apr 6;100(7):1775-83.
21463591
CPAD
P-1850
TAAMSTYTGIFTDQVLSV
18
Amyloid
Apolipoprotein C-II (ApoC-II)
P02655
No
J Mol Biol. 2007 Mar 9;366(5):1639-51.
17217959
AmyLoad
P-1851
TCFFRDHSYQEEAAVELK
18
Amyloid
Myelin-oligodendrocyte glycoprotein
Q63345
No
PLoS Biol. 2008 Aug 5;6(8):e195.
18684013
CPAD
P-1852
TVNGVGEVTATAVQGVAV
18
Amyloid
Alpha-synuclein
P37840
Eur J Biochem. 2000 Apr;267(8):2186-94.
10759841
CPAD, AmyLoad
P-1853
TYKLINGKTLKGETTTEA
18
Non-amyloid
Immunoglobulin G-binding protein G (IgG-binding protein G)
P06654
[del]233L, K245E
Eur J Biochem. 1995 Jun 1;230(2):634-49.
7607238
AmyLoad
P-1854
VTSKCGSLGNIHHKPGGG
18
Non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636-8
No
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
AmyLoad
P-1855
ARTVESRQAQDLARSYGIP
19
Non-amyloid
GTPase HRas (H-Ras-1) (Transforming protein p21)
P08642
T127S
J Mol Biol. 1995 Apr 7;247(4):648-69.
7723021
AmyLoad
P-1856
DDQQQQQQQQQQQQQQQKK
19
Amyloid
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5591-5.
11960014
CPAD
P-1857
DFSTMRRIVRNLLKELGYN
19
Non-amyloid
Chemotaxis protein CheY
Q93P00
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1858
EVVPHKKMHKDFLEKIGGL
19
Amyloid
Myohemerythrin (MHr)
P02247
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
CPAD, AmyLoad
P-1859
GDGKWMRDFEQRMNGYGSV
19
Non-amyloid
Flavodoxin
P00322
E101Q, C108S
J Mol Biol. 1995 Apr 7;247(4):648-69.
7723021
AmyLoad
P-1860
GLWVIYSTDEAKGAIVLSK
19
Non-amyloid
Myocilin
Q99972
No
J Mol Biol. 2014 Feb 20;426(4):921-35
24333014
CPAD
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Entry: P-1831 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1831
Peptide:
AYVKKLDSGTGKELVLAL
Length:
18
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q13813
UniProt Name:
SPTN1_HUMAN (SH3)
Protein Name:
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Position:
Literature
PMID:
8568894
Reference:
J Mol Biol. 1996 Jan 26;255(3):507-21.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
50.0
NuAPRpred:
-2.07
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.9
Area of the profile Above Threshold (AGGRESCAN):
4.35
Best Energy Score (PASTA 2.0):
-3.77
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1832 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
T
I
Q
H
P
W
F
K
R
T
L
G
P
F
Y
P
S
R
L
F
D
Q
F
F
G
E
G
L
F
E
Y
D
L
L
P
F
L
S
S
T
I
S
P
Y
Y
R
Q
S
L
F
R
T
V
L
D
S
G
60
61
I
S
E
V
R
S
D
R
D
K
F
V
I
F
L
D
V
K
H
F
S
P
E
D
L
T
V
K
V
Q
D
D
F
V
E
I
H
G
K
H
N
E
R
Q
D
D
H
G
Y
I
S
R
E
F
H
R
R
Y
R
L
120
121
P
S
N
V
D
Q
S
A
L
S
C
S
L
S
A
D
G
M
L
T
F
C
G
P
K
I
Q
T
G
L
D
A
T
H
A
E
R
A
I
P
V
S
R
E
E
K
P
T
S
A
P
S
S
173
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1832
Peptide:
DFVIFLDVKHFSPEDLTV
Length:
18
Classification:
Amyloid
Mutation(s):
K70D
Structure(s):
No structures
Protein Information
UniProt ID:
P02489
UniProt Name:
CRYAA_HUMAN
Protein Name:
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
Position:
70-87
Literature
PMID:
18232642
Reference:
Biochemistry. 2008 Mar 4;47(9):2961-7.
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
5
Hydrophobicity:
55.56
NuAPRpred:
-1.75
Tango:
506.83
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
20.3
Area of the profile Above Threshold (AGGRESCAN):
6.2
Best Energy Score (PASTA 2.0):
-7.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1833 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
I
V
Y
W
S
G
T
G
N
T
E
K
M
A
E
L
I
A
K
G
I
I
E
S
G
K
D
V
N
T
I
N
V
S
D
V
N
I
D
E
L
L
N
E
D
I
L
I
L
G
C
S
A
M
G
D
E
V
60
61
L
E
E
S
E
F
E
P
F
I
E
E
I
S
T
K
I
S
G
K
K
V
A
L
F
G
S
Y
G
W
G
D
G
K
W
M
R
D
F
E
E
R
M
N
G
Y
G
C
V
V
V
E
T
P
L
I
V
Q
N
E
120
121
P
D
E
A
E
Q
D
C
I
E
F
G
K
K
I
A
N
I
138
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1833
Peptide:
EESEFEPFIEEISTKISY
Length:
18
Classification:
Non-amyloid
Mutation(s):
G79Y
Structure(s):
No structures
Protein Information
UniProt ID:
P00322
UniProt Name:
FLAV_CLOBE
Protein Name:
Flavodoxin
Position:
62-79
Literature
PMID:
7723021
Reference:
J Mol Biol. 1995 Apr 7;247(4):648-69.
source:
AmyLoad
Derived Information
Net Charge:
-5
Absolute Charge:
7
Hydrophobicity:
38.89
NuAPRpred:
-2.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-9.7
Area of the profile Above Threshold (AGGRESCAN):
2.13
Best Energy Score (PASTA 2.0):
-2.7
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1834 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1834
Peptide:
EQVTNVGGAVVTGVTAVA
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
61-78
Literature
PMID:
10759841
Reference:
Eur J Biochem. 2000 Apr;267(8):2186-94.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
2.11
Tango:
430.75
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.5
Area of the profile Above Threshold (AGGRESCAN):
5.03
Best Energy Score (PASTA 2.0):
-7.24
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1835 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1835
Peptide:
FSMLVAAIQSAGLTETLN
Length:
18
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
17207483
Reference:
FEBS Lett. 2007 Jan 23;581(2):241-7.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
55.56
NuAPRpred:
-0.36
Tango:
261.53
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
18.0
Area of the profile Above Threshold (AGGRESCAN):
5.57
Best Energy Score (PASTA 2.0):
-4.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1836 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
T
I
Q
H
P
W
F
K
R
T
L
G
P
F
Y
P
S
R
L
F
D
Q
F
F
G
E
G
L
F
E
Y
D
L
L
P
F
L
S
S
T
I
S
P
Y
Y
R
Q
S
L
F
R
T
V
L
D
S
G
60
61
I
S
E
V
R
S
D
R
D
K
F
V
I
F
L
D
V
K
H
F
S
P
E
D
L
T
V
K
V
Q
D
D
F
V
E
I
H
G
K
H
N
E
R
Q
D
D
H
G
Y
I
S
R
E
F
H
R
R
Y
R
L
120
121
P
S
N
V
D
Q
S
A
L
S
C
S
L
S
A
D
G
M
L
T
F
C
G
P
K
I
Q
T
G
L
D
A
T
H
A
E
R
A
I
P
V
S
R
E
E
K
P
T
S
A
P
S
S
173
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1836
Peptide:
FVIFLDVKHFSPEDLTVK
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02489
UniProt Name:
CRYAA_HUMAN
Protein Name:
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
Position:
71-88
Literature
PMID:
18232642
Reference:
Biochemistry. 2008 Mar 4;47(9):2961-7.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
55.56
NuAPRpred:
-2.7
Tango:
279.51
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.6
Area of the profile Above Threshold (AGGRESCAN):
7.35
Best Energy Score (PASTA 2.0):
-7.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1837 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
M
R
L
I
L
F
F
G
A
L
F
G
H
I
Y
C
L
E
T
F
V
G
D
Q
V
L
E
I
V
P
S
N
E
E
Q
I
K
N
L
L
Q
L
E
A
Q
E
H
L
Q
L
D
F
W
K
S
P
T
T
60
61
P
G
E
T
A
H
V
R
V
P
F
V
N
V
Q
A
V
K
V
F
L
E
S
Q
G
I
A
Y
S
I
M
I
E
D
V
Q
V
L
L
D
K
E
N
E
E
M
L
F
N
R
R
R
E
R
S
G
N
F
N
F
120
121
G
A
Y
H
T
L
E
E
I
S
Q
E
M
D
N
L
V
A
E
H
P
G
L
V
S
K
V
N
I
G
S
S
F
E
N
R
P
M
N
V
L
K
F
S
T
G
G
D
K
P
A
I
W
L
D
A
G
I
H
A
180
181
R
E
W
V
T
Q
A
T
A
L
W
T
A
N
K
I
V
S
D
Y
G
K
D
P
S
I
T
S
I
L
D
A
L
D
I
F
L
L
P
V
T
N
P
D
G
Y
V
F
S
Q
T
K
N
R
M
W
R
K
T
R
240
241
S
K
V
S
G
S
L
C
V
G
V
D
P
N
R
N
W
D
A
G
F
G
G
P
G
A
S
S
N
P
C
S
D
S
Y
H
G
P
S
A
N
S
E
V
E
V
K
S
I
V
D
F
I
K
S
H
G
K
V
K
300
301
A
F
I
T
L
H
S
Y
S
Q
L
L
M
F
P
Y
G
Y
K
C
T
K
L
D
D
F
D
E
L
S
E
V
A
Q
K
A
A
Q
S
L
R
S
L
H
G
T
K
Y
K
V
G
P
I
C
S
V
I
Y
Q
A
360
361
S
G
G
S
I
D
W
S
Y
D
Y
G
I
K
Y
S
F
A
F
E
L
R
D
T
G
R
Y
G
F
L
L
P
A
R
Q
I
L
P
T
A
E
E
T
W
L
G
L
K
A
I
M
E
H
V
R
D
H
P
Y
419
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1837
Peptide:
FVNVEAVKAFLEAHGIAY
Length:
18
Classification:
Amyloid
Mutation(s):
Q75E, V79A, S83A, Q84H
Structure(s):
No structures
Protein Information
UniProt ID:
P48052
UniProt Name:
CBPA2_HUMAN
Protein Name:
Carboxypeptidase A2
Position:
71-88
Literature
PMID:
11045616
Reference:
Protein Sci. 2000 Sep;9(9):1700-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
66.67
NuAPRpred:
0.44
Tango:
10.98
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
19.6
Area of the profile Above Threshold (AGGRESCAN):
4.78
Best Energy Score (PASTA 2.0):
-4.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1838 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
M
R
L
I
L
F
F
G
A
L
F
G
H
I
Y
C
L
E
T
F
V
G
D
Q
V
L
E
I
V
P
S
N
E
E
Q
I
K
N
L
L
Q
L
E
A
Q
E
H
L
Q
L
D
F
W
K
S
P
T
T
60
61
P
G
E
T
A
H
V
R
V
P
F
V
N
V
Q
A
V
K
V
F
L
E
S
Q
G
I
A
Y
S
I
M
I
E
D
V
Q
V
L
L
D
K
E
N
E
E
M
L
F
N
R
R
R
E
R
S
G
N
F
N
F
120
121
G
A
Y
H
T
L
E
E
I
S
Q
E
M
D
N
L
V
A
E
H
P
G
L
V
S
K
V
N
I
G
S
S
F
E
N
R
P
M
N
V
L
K
F
S
T
G
G
D
K
P
A
I
W
L
D
A
G
I
H
A
180
181
R
E
W
V
T
Q
A
T
A
L
W
T
A
N
K
I
V
S
D
Y
G
K
D
P
S
I
T
S
I
L
D
A
L
D
I
F
L
L
P
V
T
N
P
D
G
Y
V
F
S
Q
T
K
N
R
M
W
R
K
T
R
240
241
S
K
V
S
G
S
L
C
V
G
V
D
P
N
R
N
W
D
A
G
F
G
G
P
G
A
S
S
N
P
C
S
D
S
Y
H
G
P
S
A
N
S
E
V
E
V
K
S
I
V
D
F
I
K
S
H
G
K
V
K
300
301
A
F
I
T
L
H
S
Y
S
Q
L
L
M
F
P
Y
G
Y
K
C
T
K
L
D
D
F
D
E
L
S
E
V
A
Q
K
A
A
Q
S
L
R
S
L
H
G
T
K
Y
K
V
G
P
I
C
S
V
I
Y
Q
A
360
361
S
G
G
S
I
D
W
S
Y
D
Y
G
I
K
Y
S
F
A
F
E
L
R
D
T
G
R
Y
G
F
L
L
P
A
R
Q
I
L
P
T
A
E
E
T
W
L
G
L
K
A
I
M
E
H
V
R
D
H
P
Y
419
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1838
Peptide:
FVNVQAVKVFLESQGIAY
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P48052
UniProt Name:
CBPA2_HUMAN
Protein Name:
Carboxypeptidase A2
Position:
71-88
Literature
PMID:
11045616
Reference:
Protein Sci. 2000 Sep;9(9):1700-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
61.11
NuAPRpred:
2.85
Tango:
22.82
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.2
Area of the profile Above Threshold (AGGRESCAN):
6.2
Best Energy Score (PASTA 2.0):
-7.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1839 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1839
Peptide:
GNLPFLGTAGVAGEFPTA
Length:
18
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
CHB6_BOMMO
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
55.56
NuAPRpred:
-5.45
Tango:
2.72
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.1
Area of the profile Above Threshold (AGGRESCAN):
2.72
Best Energy Score (PASTA 2.0):
-0.56
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1840 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
F
V
R
L
L
A
L
A
L
A
L
A
L
G
P
A
A
T
L
A
G
P
A
K
S
P
Y
Q
L
V
L
Q
H
S
R
L
R
G
R
Q
H
G
P
N
V
C
A
V
Q
K
V
I
G
T
N
R
K
60
61
Y
F
T
N
C
K
Q
W
Y
Q
R
K
I
C
G
K
S
T
V
I
S
Y
E
C
C
P
G
Y
E
K
V
P
G
E
K
G
C
P
A
A
L
P
L
S
N
L
Y
E
T
L
G
V
V
G
S
T
T
T
Q
L
120
121
Y
T
D
R
T
E
K
L
R
P
E
M
E
G
P
G
S
F
T
I
F
A
P
S
N
E
A
W
A
S
L
P
A
E
V
L
D
S
L
V
S
N
V
N
I
E
L
L
N
A
L
R
Y
H
M
V
G
R
R
V
180
181
L
T
D
E
L
K
H
G
M
T
L
T
S
M
Y
Q
N
S
N
I
Q
I
H
H
Y
P
N
G
I
V
T
V
N
C
A
R
L
L
K
A
D
H
H
A
T
N
G
V
V
H
L
I
D
K
V
I
S
T
I
T
240
241
N
N
I
Q
Q
I
I
E
I
E
D
T
F
E
T
L
R
A
A
V
A
A
S
G
L
N
T
M
L
E
G
N
G
Q
Y
T
L
L
A
P
T
N
E
A
F
E
K
I
P
S
E
T
L
N
R
I
L
G
D
P
300
301
E
A
L
R
D
L
L
N
N
H
I
L
K
S
A
M
C
A
E
A
I
V
A
G
L
S
V
E
T
L
E
G
T
T
L
E
V
G
C
S
G
D
M
L
T
I
N
G
K
A
I
I
S
N
K
D
I
L
A
T
360
361
N
G
V
I
H
Y
I
D
E
L
L
I
P
D
S
A
K
T
L
F
E
L
A
A
E
S
D
V
S
T
A
I
D
L
F
R
Q
A
G
L
G
N
H
L
S
G
S
E
R
L
T
L
L
A
P
L
N
S
V
F
420
421
K
D
G
T
P
P
I
D
A
H
T
R
N
L
L
R
N
H
I
I
K
D
Q
L
A
S
K
Y
L
Y
H
G
Q
T
L
E
T
L
G
G
K
K
L
R
V
F
V
Y
R
N
S
L
C
I
E
N
S
C
I
A
480
481
A
H
D
K
R
G
R
Y
G
T
L
F
T
M
D
R
V
L
T
P
P
M
G
T
V
M
D
V
L
K
G
D
N
R
F
S
M
L
V
A
A
I
Q
S
A
G
L
T
E
T
L
N
R
E
G
V
Y
T
V
F
540
541
A
P
T
N
E
A
F
R
A
L
P
P
R
E
R
S
R
L
L
G
D
A
K
E
L
A
N
I
L
K
Y
H
I
G
D
E
I
L
V
S
G
G
I
G
A
L
V
R
L
K
S
L
Q
G
D
K
L
E
V
S
600
601
L
K
N
N
V
V
S
V
N
K
E
P
V
A
E
P
D
I
M
A
T
N
G
V
V
H
V
I
T
N
V
L
Q
P
P
A
N
R
P
Q
E
R
G
D
E
L
A
D
S
A
L
E
I
F
K
Q
A
S
A
F
660
661
S
R
A
S
Q
R
S
V
R
L
A
P
V
Y
Q
K
L
L
E
R
M
K
H
683
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1840
Peptide:
GSTTTQLYTDCTEKLRPE
Length:
18
Classification:
Amyloid
Mutation(s):
R124C
Structure(s):
No structures
Protein Information
UniProt ID:
Q15582
UniProt Name:
BGH3_HUMAN
Protein Name:
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3)
Position:
114-131
Literature
PMID:
12392546
Reference:
Eur J Biochem. 2002 Nov;269(21):5149-56.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
27.78
NuAPRpred:
-4.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.2
Area of the profile Above Threshold (AGGRESCAN):
0.69
Best Energy Score (PASTA 2.0):
-2.04
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1841 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
F
V
R
L
L
A
L
A
L
A
L
A
L
G
P
A
A
T
L
A
G
P
A
K
S
P
Y
Q
L
V
L
Q
H
S
R
L
R
G
R
Q
H
G
P
N
V
C
A
V
Q
K
V
I
G
T
N
R
K
60
61
Y
F
T
N
C
K
Q
W
Y
Q
R
K
I
C
G
K
S
T
V
I
S
Y
E
C
C
P
G
Y
E
K
V
P
G
E
K
G
C
P
A
A
L
P
L
S
N
L
Y
E
T
L
G
V
V
G
S
T
T
T
Q
L
120
121
Y
T
D
R
T
E
K
L
R
P
E
M
E
G
P
G
S
F
T
I
F
A
P
S
N
E
A
W
A
S
L
P
A
E
V
L
D
S
L
V
S
N
V
N
I
E
L
L
N
A
L
R
Y
H
M
V
G
R
R
V
180
181
L
T
D
E
L
K
H
G
M
T
L
T
S
M
Y
Q
N
S
N
I
Q
I
H
H
Y
P
N
G
I
V
T
V
N
C
A
R
L
L
K
A
D
H
H
A
T
N
G
V
V
H
L
I
D
K
V
I
S
T
I
T
240
241
N
N
I
Q
Q
I
I
E
I
E
D
T
F
E
T
L
R
A
A
V
A
A
S
G
L
N
T
M
L
E
G
N
G
Q
Y
T
L
L
A
P
T
N
E
A
F
E
K
I
P
S
E
T
L
N
R
I
L
G
D
P
300
301
E
A
L
R
D
L
L
N
N
H
I
L
K
S
A
M
C
A
E
A
I
V
A
G
L
S
V
E
T
L
E
G
T
T
L
E
V
G
C
S
G
D
M
L
T
I
N
G
K
A
I
I
S
N
K
D
I
L
A
T
360
361
N
G
V
I
H
Y
I
D
E
L
L
I
P
D
S
A
K
T
L
F
E
L
A
A
E
S
D
V
S
T
A
I
D
L
F
R
Q
A
G
L
G
N
H
L
S
G
S
E
R
L
T
L
L
A
P
L
N
S
V
F
420
421
K
D
G
T
P
P
I
D
A
H
T
R
N
L
L
R
N
H
I
I
K
D
Q
L
A
S
K
Y
L
Y
H
G
Q
T
L
E
T
L
G
G
K
K
L
R
V
F
V
Y
R
N
S
L
C
I
E
N
S
C
I
A
480
481
A
H
D
K
R
G
R
Y
G
T
L
F
T
M
D
R
V
L
T
P
P
M
G
T
V
M
D
V
L
K
G
D
N
R
F
S
M
L
V
A
A
I
Q
S
A
G
L
T
E
T
L
N
R
E
G
V
Y
T
V
F
540
541
A
P
T
N
E
A
F
R
A
L
P
P
R
E
R
S
R
L
L
G
D
A
K
E
L
A
N
I
L
K
Y
H
I
G
D
E
I
L
V
S
G
G
I
G
A
L
V
R
L
K
S
L
Q
G
D
K
L
E
V
S
600
601
L
K
N
N
V
V
S
V
N
K
E
P
V
A
E
P
D
I
M
A
T
N
G
V
V
H
V
I
T
N
V
L
Q
P
P
A
N
R
P
Q
E
R
G
D
E
L
A
D
S
A
L
E
I
F
K
Q
A
S
A
F
660
661
S
R
A
S
Q
R
S
V
R
L
A
P
V
Y
Q
K
L
L
E
R
M
K
H
683
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1841
Peptide:
GSTTTQLYTDRTEKLRPE
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q15582
UniProt Name:
BGH3_HUMAN
Protein Name:
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3)
Position:
114-131
Literature
PMID:
12392546
Reference:
Eur J Biochem. 2002 Nov;269(21):5149-56.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
6
Hydrophobicity:
22.22
NuAPRpred:
-6.69
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-40.4
Area of the profile Above Threshold (AGGRESCAN):
0.44
Best Energy Score (PASTA 2.0):
-2.27
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1842 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1842
Peptide:
GVGKSALTIQLIQNHFVY
Length:
18
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
P21-ras
Protein Name:
Position:
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
3.87
Tango:
63.39
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.9
Area of the profile Above Threshold (AGGRESCAN):
4.36
Best Energy Score (PASTA 2.0):
-5.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1843 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
G
W
E
I
P
E
P
Y
V
W
D
E
S
F
R
V
F
Y
E
Q
L
D
E
E
H
K
K
I
F
K
G
I
F
D
C
I
R
D
N
S
A
P
N
L
A
T
L
V
K
V
T
T
N
H
F
T
H
E
E
A
60
61
M
M
D
A
A
K
Y
S
E
V
V
P
H
K
K
M
H
K
D
F
L
E
K
I
G
G
L
S
A
P
V
D
A
K
N
V
D
Y
C
K
E
W
L
V
N
H
I
K
G
T
D
F
K
Y
K
G
K
L
118
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1843
Peptide:
GWEIPEPYVWDESFRVFY
Length:
18
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02247
UniProt Name:
HEMTM_THEHE
Protein Name:
Myohemerythrin (MHr)
Position:
1-18
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
5
Hydrophobicity:
61.11
NuAPRpred:
-6.3
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.9
Area of the profile Above Threshold (AGGRESCAN):
4.01
Best Energy Score (PASTA 2.0):
-3.13
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1844 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1844
Peptide:
IKYLEFISQAIIHVLHSR
Length:
18
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
MYG_HUMAN
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
55.56
NuAPRpred:
8.92
Tango:
94.55
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.3
Area of the profile Above Threshold (AGGRESCAN):
7.95
Best Energy Score (PASTA 2.0):
-6.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1845 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
T
I
Q
H
P
W
F
K
R
T
L
G
P
F
Y
P
S
R
L
F
D
Q
F
F
G
E
G
L
F
E
Y
D
L
L
P
F
L
S
S
T
I
S
P
Y
Y
R
Q
S
L
F
R
T
V
L
D
S
G
60
61
I
S
E
V
R
S
D
R
D
K
F
V
I
F
L
D
V
K
H
F
S
P
E
D
L
T
V
K
V
Q
D
D
F
V
E
I
H
G
K
H
N
E
R
Q
D
D
H
G
Y
I
S
R
E
F
H
R
R
Y
R
L
120
121
P
S
N
V
D
Q
S
A
L
S
C
S
L
S
A
D
G
M
L
T
F
C
G
P
K
I
Q
T
G
L
D
A
T
H
A
E
R
A
I
P
V
S
R
E
E
K
P
T
S
A
P
S
S
173
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1845
Peptide:
KFVIFLDVKHFSPEDLTV
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02489
UniProt Name:
CRYAA_HUMAN
Protein Name:
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
Position:
70-87
Literature
PMID:
18232642
Reference:
Biochemistry. 2008 Mar 4;47(9):2961-7.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
55.56
NuAPRpred:
-1.46
Tango:
499.5
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.3
Area of the profile Above Threshold (AGGRESCAN):
6.83
Best Energy Score (PASTA 2.0):
-7.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1846 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1846
Peptide:
MPEEELLNAPGETYVVTL
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
57-74
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-4
Absolute Charge:
4
Hydrophobicity:
55.56
NuAPRpred:
-3.61
Tango:
25.17
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.4
Area of the profile Above Threshold (AGGRESCAN):
4.31
Best Energy Score (PASTA 2.0):
-5.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1847 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1847
Peptide:
NGERIEKVEHSDLSFSKD
Length:
18
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
62-79
Literature
PMID:
12488093
Reference:
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
8
Hydrophobicity:
22.22
NuAPRpred:
-3.99
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-42.5
Area of the profile Above Threshold (AGGRESCAN):
0.67
Best Energy Score (PASTA 2.0):
-3.21
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1848 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
60
61
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
120
121
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
180
181
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
240
241
N
T
Q
243
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1848
Peptide:
PVTQEFWDNLEKETEGLR
Length:
18
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I
Position:
66-83
Literature
PMID:
24316228
Reference:
FEBS Lett. 2014 Jan 31;588(3):389-94
source:
CPAD
Derived Information
Net Charge:
-3
Absolute Charge:
7
Hydrophobicity:
33.33
NuAPRpred:
-4.16
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-43.4
Area of the profile Above Threshold (AGGRESCAN):
0.37
Best Energy Score (PASTA 2.0):
-1.46
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1849 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
E
T
Q
R
A
S
L
C
L
G
R
W
S
L
W
L
L
L
L
A
L
V
V
P
S
A
S
A
Q
A
L
S
Y
R
E
A
V
L
R
A
V
D
R
L
N
E
Q
S
S
E
A
N
L
Y
R
L
L
E
L
60
61
D
Q
P
P
K
A
D
E
D
P
G
T
P
K
P
V
S
F
T
V
K
E
T
V
C
P
R
P
T
R
Q
P
P
E
L
C
D
F
K
E
N
G
R
V
K
Q
C
V
G
T
V
T
L
D
Q
I
K
D
P
L
120
121
D
I
T
C
N
E
V
Q
G
V
R
G
G
R
L
C
Y
C
R
R
R
F
C
V
C
V
G
R
G
149
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1849
Peptide:
RGGRLCYCRRRFCVCVGR
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32194
UniProt Name:
PG1_PIG
Protein Name:
Protegrin-1 (PG-1) (Neutrophil peptide 1)
Position:
131-148
Literature
PMID:
21463591
Reference:
Biophys J. 2011 Apr 6;100(7):1775-83.
source:
CPAD
Derived Information
Net Charge:
6
Absolute Charge:
6
Hydrophobicity:
50.0
NuAPRpred:
3.49
Tango:
15.58
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
4.7
Area of the profile Above Threshold (AGGRESCAN):
4.8
Best Energy Score (PASTA 2.0):
-8.13
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1850 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
T
R
L
L
P
A
L
F
L
V
L
L
V
L
G
F
E
V
Q
G
T
Q
Q
P
Q
Q
D
E
M
P
S
P
T
F
L
T
Q
V
K
E
S
L
S
S
Y
W
E
S
A
K
T
A
A
Q
N
L
Y
E
60
61
K
T
Y
L
P
A
V
D
E
K
L
R
D
L
Y
S
K
S
T
A
A
M
S
T
Y
T
G
I
F
T
D
Q
V
L
S
V
L
K
G
E
E
101
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1850
Peptide:
TAAMSTYTGIFTDQVLSV
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02655
UniProt Name:
APOC2_HUMAN
Protein Name:
Apolipoprotein C-II (ApoC-II)
Position:
79-96
Literature
PMID:
17217959
Reference:
J Mol Biol. 2007 Mar 9;366(5):1639-51.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-2.45
Tango:
26.17
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.5
Area of the profile Above Threshold (AGGRESCAN):
5.01
Best Energy Score (PASTA 2.0):
-4.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1851 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
V
W
S
L
S
L
P
S
C
L
L
S
L
L
L
L
L
Q
L
S
R
S
Y
A
G
Q
F
R
V
I
G
P
G
H
P
I
R
A
L
V
G
D
E
A
E
L
P
C
R
I
S
P
G
K
N
A
T
60
61
G
M
E
V
G
W
Y
R
S
P
F
S
R
V
V
H
L
Y
R
N
G
K
D
Q
D
A
E
Q
A
P
E
Y
R
G
R
T
E
L
L
K
E
S
I
G
E
G
K
V
A
L
R
I
Q
N
V
R
F
S
D
E
120
121
G
G
Y
T
C
F
F
R
D
H
S
Y
Q
E
E
A
A
V
E
L
K
V
E
D
P
F
Y
W
I
N
P
G
V
L
A
L
I
A
L
V
P
M
L
L
L
Q
V
S
V
G
L
V
F
L
F
L
Q
H
R
L
180
181
R
G
K
L
R
A
E
V
E
N
L
H
R
T
F
D
P
H
F
L
R
V
P
C
W
K
I
T
L
F
V
I
V
P
V
L
G
P
L
V
A
L
I
I
C
Y
N
W
L
H
R
R
L
A
G
Q
F
L
E
E
240
241
L
R
N
P
F
245
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1851
Peptide:
TCFFRDHSYQEEAAVELK
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q63345
UniProt Name:
MOG_RAT
Protein Name:
Myelin-oligodendrocyte glycoprotein
Position:
124-141
Literature
PMID:
18684013
Reference:
PLoS Biol. 2008 Aug 5;6(8):e195.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
6
Hydrophobicity:
44.44
NuAPRpred:
-4.38
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-17.6
Area of the profile Above Threshold (AGGRESCAN):
2.46
Best Energy Score (PASTA 2.0):
-2.61
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1852 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1852
Peptide:
TVNGVGEVTATAVQGVAV
Length:
18
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
scrambled
Literature
PMID:
10759841
Reference:
Eur J Biochem. 2000 Apr;267(8):2186-94.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-1.33
Tango:
6.15
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.9
Area of the profile Above Threshold (AGGRESCAN):
2.95
Best Energy Score (PASTA 2.0):
-3.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1853 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
E
K
E
K
K
V
K
Y
F
L
R
K
S
A
F
G
L
A
S
V
S
A
A
F
L
V
G
S
T
V
F
A
V
D
S
P
I
E
D
T
P
I
I
R
N
G
G
E
L
T
N
L
L
G
N
S
E
T
T
60
61
L
A
L
R
N
E
E
S
A
T
A
D
L
T
A
A
A
V
A
D
T
V
A
A
A
A
A
E
N
A
G
A
A
A
W
E
A
A
A
A
A
D
A
L
A
K
A
K
A
D
A
L
K
E
F
N
K
Y
G
V
120
121
S
D
Y
Y
K
N
L
I
N
N
A
K
T
V
E
G
I
K
D
L
Q
A
Q
V
V
E
S
A
K
K
A
R
I
S
E
A
T
D
G
L
S
D
F
L
K
S
Q
T
P
A
E
D
T
V
K
S
I
E
L
A
180
181
E
A
K
V
L
A
N
R
E
L
D
K
Y
G
V
S
D
Y
H
K
N
L
I
N
N
A
K
T
V
E
G
V
K
E
L
I
D
E
I
L
A
A
L
P
K
T
D
T
Y
K
L
I
L
N
G
K
T
L
K
G
240
241
E
T
T
T
E
A
V
D
A
A
T
A
E
K
V
F
K
Q
Y
A
N
D
N
G
V
D
G
E
W
T
Y
D
D
A
T
K
T
F
T
V
T
E
K
P
E
V
I
D
A
S
E
L
T
P
A
V
T
T
Y
K
300
301
L
V
I
N
G
K
T
L
K
G
E
T
T
T
K
A
V
D
A
E
T
A
E
K
A
F
K
Q
Y
A
N
D
N
G
V
D
G
V
W
T
Y
D
D
A
T
K
T
F
T
V
T
E
M
V
T
E
V
P
G
D
360
361
A
P
T
E
P
E
K
P
E
A
S
I
P
L
V
P
L
T
P
A
T
P
I
A
K
D
D
A
K
K
D
D
T
K
K
E
D
A
K
K
P
E
A
K
K
D
D
A
K
K
A
E
T
L
P
T
T
G
E
G
420
421
S
N
P
F
F
T
A
A
A
L
A
V
M
A
G
A
G
A
L
A
V
A
S
K
R
K
E
D
448
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1853
Peptide:
TYKLINGKTLKGETTTEA
Length:
18
Classification:
Non-amyloid
Mutation(s):
[del]233L, K245E
Structure(s):
No structures
Protein Information
UniProt ID:
P06654
UniProt Name:
SPG1_STRSG
Protein Name:
Immunoglobulin G-binding protein G (IgG-binding protein G)
Position:
228-246
Literature
PMID:
7607238
Reference:
Eur J Biochem. 1995 Jun 1;230(2):634-49.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
27.78
NuAPRpred:
-3.93
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-21.1
Area of the profile Above Threshold (AGGRESCAN):
1.33
Best Energy Score (PASTA 2.0):
-1.9
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1854 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
180
181
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
240
241
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
300
301
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
360
361
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
420
421
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
441
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1854
Peptide:
VTSKCGSLGNIHHKPGGG
Length:
18
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10636-8
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
318-335
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
27.78
NuAPRpred:
-1.17
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-28.9
Area of the profile Above Threshold (AGGRESCAN):
0.71
Best Energy Score (PASTA 2.0):
-1.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1855 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
E
Y
K
L
V
V
V
G
A
G
G
V
G
K
S
A
L
T
I
Q
L
I
Q
N
H
F
V
D
E
Y
D
P
T
I
E
D
S
Y
R
K
Q
V
V
I
D
G
E
T
C
L
L
D
I
L
D
T
A
G
60
61
Q
E
E
Y
S
A
M
R
D
Q
Y
M
R
T
G
E
G
F
L
C
V
F
A
I
N
N
T
K
S
F
E
D
I
H
Q
Y
R
E
Q
I
K
R
V
K
D
S
D
D
V
P
M
V
L
V
G
N
K
C
D
L
120
121
P
A
R
T
V
E
T
R
Q
A
Q
D
L
A
R
S
Y
G
I
P
Y
I
E
T
S
A
K
T
R
Q
G
V
E
D
A
F
Y
T
L
V
R
E
I
R
Q
H
K
L
R
K
L
N
P
P
D
E
S
G
P
G
180
181
C
M
N
C
K
C
V
I
S
189
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1855
Peptide:
ARTVESRQAQDLARSYGIP
Length:
19
Classification:
Non-amyloid
Mutation(s):
T127S
Structure(s):
No structures
Protein Information
UniProt ID:
P08642
UniProt Name:
RASH_CHICK
Protein Name:
GTPase HRas (H-Ras-1) (Transforming protein p21)
Position:
122-140
Literature
PMID:
7723021
Reference:
J Mol Biol. 1995 Apr 7;247(4):648-69.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
42.11
NuAPRpred:
-7.71
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.0
Area of the profile Above Threshold (AGGRESCAN):
1.02
Best Energy Score (PASTA 2.0):
-1.36
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1856 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1856
Peptide:
DDQQQQQQQQQQQQQQQKK
Length:
19
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
11960014
Reference:
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5591-5.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
0.0
NuAPRpred:
-1.8
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-125.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.04
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1857 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
D
K
E
L
K
F
L
V
V
D
D
F
S
T
M
R
R
I
V
R
N
L
L
K
E
L
G
F
N
N
V
E
E
A
E
D
G
L
D
A
L
N
K
L
Q
A
G
G
Y
G
F
V
I
S
D
W
N
M
60
61
P
N
M
D
G
L
E
L
L
K
T
I
R
A
D
G
A
M
S
A
L
P
V
L
M
V
T
A
E
A
K
K
E
N
I
I
A
A
A
Q
A
G
A
S
G
Y
V
V
K
P
F
T
A
A
T
L
E
E
K
L
120
121
N
K
I
F
E
K
L
G
M
129
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1857
Peptide:
DFSTMRRIVRNLLKELGYN
Length:
19
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q93P00
UniProt Name:
CHEY_ECOL6
Protein Name:
Chemotaxis protein CheY
Position:
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
6
Hydrophobicity:
42.11
NuAPRpred:
-2.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.5
Area of the profile Above Threshold (AGGRESCAN):
1.97
Best Energy Score (PASTA 2.0):
-4.22
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1858 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
G
W
E
I
P
E
P
Y
V
W
D
E
S
F
R
V
F
Y
E
Q
L
D
E
E
H
K
K
I
F
K
G
I
F
D
C
I
R
D
N
S
A
P
N
L
A
T
L
V
K
V
T
T
N
H
F
T
H
E
E
A
60
61
M
M
D
A
A
K
Y
S
E
V
V
P
H
K
K
M
H
K
D
F
L
E
K
I
G
G
L
S
A
P
V
D
A
K
N
V
D
Y
C
K
E
W
L
V
N
H
I
K
G
T
D
F
K
Y
K
G
K
L
118
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1858
Peptide:
EVVPHKKMHKDFLEKIGGL
Length:
19
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02247
UniProt Name:
HEMTM_THEHE
Protein Name:
Myohemerythrin (MHr)
Position:
69-87
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
7
Hydrophobicity:
42.11
NuAPRpred:
-3.04
Tango:
1.11
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.7
Area of the profile Above Threshold (AGGRESCAN):
1.45
Best Energy Score (PASTA 2.0):
-1.74
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1859 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
I
V
Y
W
S
G
T
G
N
T
E
K
M
A
E
L
I
A
K
G
I
I
E
S
G
K
D
V
N
T
I
N
V
S
D
V
N
I
D
E
L
L
N
E
D
I
L
I
L
G
C
S
A
M
G
D
E
V
60
61
L
E
E
S
E
F
E
P
F
I
E
E
I
S
T
K
I
S
G
K
K
V
A
L
F
G
S
Y
G
W
G
D
G
K
W
M
R
D
F
E
E
R
M
N
G
Y
G
C
V
V
V
E
T
P
L
I
V
Q
N
E
120
121
P
D
E
A
E
Q
D
C
I
E
F
G
K
K
I
A
N
I
138
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1859
Peptide:
GDGKWMRDFEQRMNGYGSV
Length:
19
Classification:
Non-amyloid
Mutation(s):
E101Q, C108S
Structure(s):
No structures
Protein Information
UniProt ID:
P00322
UniProt Name:
FLAV_CLOBE
Protein Name:
Flavodoxin
Position:
91-109
Literature
PMID:
7723021
Reference:
J Mol Biol. 1995 Apr 7;247(4):648-69.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
6
Hydrophobicity:
31.58
NuAPRpred:
-6.67
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-37.5
Area of the profile Above Threshold (AGGRESCAN):
0.82
Best Energy Score (PASTA 2.0):
-1.61
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1860 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
R
T
A
Q
L
R
K
A
N
D
Q
S
G
R
C
Q
Y
T
F
S
V
A
S
P
N
E
S
S
C
P
E
Q
S
Q
A
M
S
V
I
H
N
L
Q
R
D
S
S
T
Q
R
L
D
L
E
A
T
K
A
R
L
60
61
S
S
L
E
S
L
L
H
Q
L
T
L
D
Q
A
A
R
P
Q
E
T
Q
E
G
L
Q
R
E
L
G
T
L
R
R
E
R
D
Q
L
E
T
Q
T
R
E
L
E
T
A
Y
S
N
L
L
R
D
K
S
V
L
120
121
E
E
E
K
K
R
L
R
Q
E
N
E
N
L
A
R
R
L
E
S
S
S
Q
E
V
A
R
L
R
R
G
Q
C
P
Q
T
R
D
T
A
R
A
V
P
P
G
S
R
E
V
S
T
W
N
L
D
T
L
A
F
180
181
Q
E
L
K
S
E
L
T
E
V
P
A
S
R
I
L
K
E
S
P
S
G
Y
L
R
S
G
E
G
D
T
G
C
G
E
L
V
W
V
G
E
P
L
T
L
R
T
A
E
T
I
T
G
K
Y
G
V
W
M
R
240
241
D
P
K
P
T
Y
P
Y
T
Q
E
T
T
W
R
I
D
T
V
G
T
D
V
R
Q
V
F
E
Y
D
L
I
S
Q
F
M
Q
G
Y
P
S
K
V
H
I
L
P
R
P
L
E
S
T
G
A
V
V
Y
S
G
300
301
S
L
Y
F
Q
G
A
E
S
R
T
V
I
R
Y
E
L
N
T
E
T
V
K
A
E
K
E
I
P
G
A
G
Y
H
G
Q
F
P
Y
S
W
G
G
Y
T
D
I
D
L
A
V
D
E
A
G
L
W
V
I
Y
360
361
S
T
D
E
A
K
G
A
I
V
L
S
K
L
N
P
E
N
L
E
L
E
Q
T
W
E
T
N
I
R
K
Q
S
V
A
N
A
F
I
I
C
G
T
L
Y
T
V
S
S
Y
T
S
A
D
A
T
V
N
F
A
420
421
Y
D
T
G
T
G
I
S
K
T
L
T
I
P
F
K
N
R
Y
K
Y
S
S
M
I
D
Y
N
P
L
E
K
K
L
F
A
W
D
N
L
N
M
V
T
Y
D
I
K
L
S
K
M
472
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1860
Peptide:
GLWVIYSTDEAKGAIVLSK
Length:
19
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q99972
UniProt Name:
MYOC_HUMAN
Protein Name:
Myocilin
Position:
355-373
Literature
PMID:
24333014
Reference:
J Mol Biol. 2014 Feb 20;426(4):921-35
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
52.63
NuAPRpred:
1.01
Tango:
625.14
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.8
Area of the profile Above Threshold (AGGRESCAN):
8.86
Best Energy Score (PASTA 2.0):
-6.07
Aggregate Orientation (PASTA 2.0):
Parallel
