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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 631 to 660 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0631
LQIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623L
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0632
LQNVSN
6
Non-amyloid
Transcriptional activator/repressor MOT3
P54785
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0633
LQSSWG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0634
LQTDAR
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0635
LQTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39Q
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0636
LRTVYV
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39R
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0637
LSFSKD
6
Amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0638
LSGDHC
6
Non-amyloid
Superoxide dismutase (hSod1)
P00441
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0639
LSQPKI
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0640
LSTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39S
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0641
LTFIQV
6
Non-amyloid
Beta-galactosidase
P16278
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0642
LTITQH
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0643
LTQRGF
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0644
LTTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39T
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0645
LTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0646
LVEALY
6
Amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0647
LVFYQQ
6
Amyloid
Alstrom syndrome protein 1
Q8TCU4
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0648
LVHSSN
6
amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
J Phys Chem B. 2016 Jul 7;120(26):5810-6.
26629790
Waltz-DB 2.0
P-0649
LVSSSG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0650
LVTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39V
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0651
LWTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39W
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0652
LYQLEN
6
Amyloid
Insulin
P01308
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0653
LYTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39Y
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0654
LYVLIV
6
Amyloid
Probable G-protein coupled receptor 21
Q99679
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-0655
MAAAQA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0656
MATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38M
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0657
MCSIFQ
6
Amyloid
Protoheme IX farnesyltransferase
Q12887
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-0658
MERLRI
6
Non-amyloid
von Willebrand factor (vWF)
P04275
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0659
MEWLRI
6
Non-amyloid
von Willebrand factor (vWF)
P04275
R1306W
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0660
MGGGMN
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0631 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0631
Peptide:
LQIVYK
Length:
6
Classification:
amyloid
Mutation(s):
V623L
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.63
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
53.8
Area of the profile Above Threshold (AGGRESCAN):
3.55
Best Energy Score (PASTA 2.0):
-3.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0632 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
A
D
H
H
L
Q
Q
Q
Q
Q
Q
R
Q
Q
H
Q
Q
Q
Q
H
Q
Q
Q
Q
H
Q
H
Q
H
Q
Q
Q
Q
H
T
I
L
Q
N
V
S
N
T
N
N
I
G
S
D
S
L
A
S
Q
P
F
N
T
60
61
T
T
V
S
S
N
K
D
D
V
M
V
N
S
G
A
R
E
L
P
M
P
L
H
Q
Q
Q
Y
I
Y
P
Y
Y
Q
Y
T
S
N
N
S
N
N
N
N
V
T
A
G
N
N
M
S
A
S
P
I
V
H
N
N
120
121
S
N
N
S
N
N
S
N
I
S
A
S
D
Y
T
V
A
N
N
S
T
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
H
P
N
Q
F
T
A
A
A
N
M
N
S
N
A
A
A
A
A
Y
Y
S
180
181
F
P
T
A
N
M
P
I
P
Q
Q
D
Q
Q
Y
M
F
N
P
A
S
Y
I
S
H
Y
Y
S
A
V
N
S
N
N
N
G
N
N
A
A
N
N
G
S
N
N
S
S
H
S
A
P
A
P
A
P
G
P
P
H
240
241
H
H
H
H
H
S
N
T
H
N
N
L
N
N
G
G
A
V
N
T
N
N
A
P
Q
H
H
P
T
I
I
T
D
Q
F
Q
F
Q
L
Q
Q
N
P
S
P
N
L
N
L
N
I
N
P
A
Q
P
L
H
L
P
300
301
P
G
W
K
I
N
T
M
P
Q
P
R
P
T
T
A
P
N
H
P
P
A
P
V
P
S
S
N
P
V
A
S
N
L
V
P
A
P
S
S
D
H
K
Y
I
H
Q
C
Q
F
C
E
K
S
F
K
R
K
S
W
360
361
L
K
R
H
L
L
S
H
S
Q
Q
R
H
F
L
C
P
W
C
L
S
R
Q
K
R
K
D
N
L
L
Q
H
M
K
L
K
H
T
N
Y
L
L
D
E
L
K
K
N
N
I
I
F
N
Y
N
N
S
S
S
S
420
421
N
N
N
N
D
N
N
N
N
N
N
S
N
S
A
S
G
S
G
G
A
G
A
A
A
A
A
A
T
A
P
E
N
E
D
G
N
G
Y
D
T
N
I
K
T
L
I
N
D
G
V
L
N
K
D
D
V
K
R
V
480
481
L
N
N
L
I
V
S
H
N
K
490
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0632
Peptide:
LQNVSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P54785
UniProt Name:
MOT3_YEAST
Protein Name:
Transcriptional activator/repressor MOT3
Position:
39-44
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-31.8
Area of the profile Above Threshold (AGGRESCAN):
0.05
Best Energy Score (PASTA 2.0):
-1.31
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0633 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0633
Peptide:
LQSSWG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
330-335
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.26
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.0
Area of the profile Above Threshold (AGGRESCAN):
0.14
Best Energy Score (PASTA 2.0):
-0.14
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0634 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0634
Peptide:
LQTDAR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
59-64
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.6
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-73.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.77
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0635 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0635
Peptide:
LQTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39Q
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.7
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
39.4
Area of the profile Above Threshold (AGGRESCAN):
2.49
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0636 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0636
Peptide:
LRTVYV
Length:
6
Classification:
non-amyloid
Mutation(s):
A39R
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
-0.06
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
39.3
Area of the profile Above Threshold (AGGRESCAN):
2.48
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0637 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0637
Peptide:
LSFSKD
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
3LOZ
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
74-79
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-9.8
Area of the profile Above Threshold (AGGRESCAN):
0.85
Best Energy Score (PASTA 2.0):
-0.31
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0638 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
T
K
A
V
C
V
L
K
G
D
G
P
V
Q
G
I
I
N
F
E
Q
K
E
S
N
G
P
V
K
V
W
G
S
I
K
G
L
T
E
G
L
H
G
F
H
V
H
E
F
G
D
N
T
A
G
C
T
S
60
61
A
G
P
H
F
N
P
L
S
R
K
H
G
G
P
K
D
E
E
R
H
V
G
D
L
G
N
V
T
A
D
K
D
G
V
A
D
V
S
I
E
D
S
V
I
S
L
S
G
D
H
C
I
I
G
R
T
L
V
V
120
121
H
E
K
A
D
D
L
G
K
G
G
N
E
E
S
T
K
T
G
N
A
G
S
R
L
A
C
G
V
I
G
I
A
Q
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0638
Peptide:
LSGDHC
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00441
UniProt Name:
SODC_HUMAN
Protein Name:
Superoxide dismutase (hSod1)
Position:
107-112
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
0.12
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-63.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.89
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0639 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0639
Peptide:
LSQPKI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
107-112
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-33.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.08
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0640 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0640
Peptide:
LSTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39S
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.69
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
51.9
Area of the profile Above Threshold (AGGRESCAN):
3.33
Best Energy Score (PASTA 2.0):
-4.61
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0641 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
P
G
F
L
V
R
I
L
P
L
L
L
V
L
L
L
L
G
P
T
R
G
L
R
N
A
T
Q
R
M
F
E
I
D
Y
S
R
D
S
F
L
K
D
G
Q
P
F
R
Y
I
S
G
S
I
H
Y
S
R
V
60
61
P
R
F
Y
W
K
D
R
L
L
K
M
K
M
A
G
L
N
A
I
Q
T
Y
V
P
W
N
F
H
E
P
W
P
G
Q
Y
Q
F
S
E
D
H
D
V
E
Y
F
L
R
L
A
H
E
L
G
L
L
V
I
L
120
121
R
P
G
P
Y
I
C
A
E
W
E
M
G
G
L
P
A
W
L
L
E
K
E
S
I
L
L
R
S
S
D
P
D
Y
L
A
A
V
D
K
W
L
G
V
L
L
P
K
M
K
P
L
L
Y
Q
N
G
G
P
V
180
181
I
T
V
Q
V
E
N
E
Y
G
S
Y
F
A
C
D
F
D
Y
L
R
F
L
Q
K
R
F
R
H
H
L
G
D
D
V
V
L
F
T
T
D
G
A
H
K
T
F
L
K
C
G
A
L
Q
G
L
Y
T
T
V
240
241
D
F
G
T
G
S
N
I
T
D
A
F
L
S
Q
R
K
C
E
P
K
G
P
L
I
N
S
E
F
Y
T
G
W
L
D
H
W
G
Q
P
H
S
T
I
K
T
E
A
V
A
S
S
L
Y
D
I
L
A
R
G
300
301
A
S
V
N
L
Y
M
F
I
G
G
T
N
F
A
Y
W
N
G
A
N
S
P
Y
A
A
Q
P
T
S
Y
D
Y
D
A
P
L
S
E
A
G
D
L
T
E
K
Y
F
A
L
R
N
I
I
Q
K
F
E
K
V
360
361
P
E
G
P
I
P
P
S
T
P
K
F
A
Y
G
K
V
T
L
E
K
L
K
T
V
G
A
A
L
D
I
L
C
P
S
G
P
I
K
S
L
Y
P
L
T
F
I
Q
V
K
Q
H
Y
G
F
V
L
Y
R
T
420
421
T
L
P
Q
D
C
S
N
P
A
P
L
S
S
P
L
N
G
V
H
D
R
A
Y
V
A
V
D
G
I
P
Q
G
V
L
E
R
N
N
V
I
T
L
N
I
T
G
K
A
G
A
T
L
D
L
L
V
E
N
M
480
481
G
R
V
N
Y
G
A
Y
I
N
D
F
K
G
L
V
S
N
L
T
L
S
S
N
I
L
T
D
W
T
I
F
P
L
D
T
E
D
A
V
R
S
H
L
G
G
W
G
H
R
D
S
G
H
H
D
E
A
W
A
540
541
H
N
S
S
N
Y
T
L
P
A
F
Y
M
G
N
F
S
I
P
S
G
I
P
D
L
P
Q
D
T
F
I
Q
F
P
G
W
T
K
G
Q
V
W
I
N
G
F
N
L
G
R
Y
W
P
A
R
G
P
Q
L
T
600
601
L
F
V
P
Q
H
I
L
M
T
S
A
P
N
T
I
T
V
L
E
L
E
W
A
P
C
S
S
D
D
P
E
L
C
A
V
T
F
V
D
R
P
V
I
G
S
S
V
T
Y
D
H
P
S
K
P
V
E
K
R
660
661
L
M
P
P
P
P
Q
K
N
K
D
S
W
L
D
H
V
677
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0641
Peptide:
LTFIQV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P16278
UniProt Name:
BGAL_HUMAN
Protein Name:
Beta-galactosidase
Position:
404-409
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.9
Tango:
0.78
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
64.7
Area of the profile Above Threshold (AGGRESCAN):
4.33
Best Energy Score (PASTA 2.0):
-4.27
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0642 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0642
Peptide:
LTITQH
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
68-73
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.1
Area of the profile Above Threshold (AGGRESCAN):
1.03
Best Energy Score (PASTA 2.0):
-2.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0643 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0643
Peptide:
LTQRGF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
92-97
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-45.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.39
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0644 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0644
Peptide:
LTTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39T
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.6
Tango:
3.29
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
53.7
Area of the profile Above Threshold (AGGRESCAN):
3.46
Best Energy Score (PASTA 2.0):
-5.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0645 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0645
Peptide:
LTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
1.0
Tango:
0.9
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
72.1
Area of the profile Above Threshold (AGGRESCAN):
4.76
Best Energy Score (PASTA 2.0):
-6.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0646 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0646
Peptide:
LVEALY
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
35-40
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.83
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
18.0
Area of the profile Above Threshold (AGGRESCAN):
1.2
Best Energy Score (PASTA 2.0):
-0.83
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0647 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
E
P
E
D
L
P
W
P
G
E
L
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
A
A
A
A
A
A
A
N
V
D
D
V
V
V
V
E
E
V
E
E
E
A
G
R
E
L
D
S
D
S
H
Y
60
61
G
P
Q
H
L
E
S
I
D
D
E
E
D
E
E
A
K
A
W
L
Q
A
H
P
G
R
I
L
P
P
L
S
P
P
Q
H
R
Y
S
E
G
E
R
T
S
L
E
K
I
V
P
L
T
C
H
V
W
Q
Q
I
120
121
V
Y
Q
G
N
S
R
T
Q
I
S
D
T
N
V
V
C
L
E
T
T
A
Q
R
G
S
G
D
D
Q
K
T
E
S
W
H
C
L
P
Q
E
M
D
S
S
Q
T
L
D
T
S
Q
T
R
F
N
V
R
T
E
180
181
D
T
E
V
T
D
F
P
S
L
E
E
G
I
L
T
Q
S
E
N
Q
V
K
E
P
N
R
D
L
F
C
S
P
L
L
V
I
Q
D
S
F
A
S
P
D
L
P
L
L
T
C
L
T
Q
D
Q
E
F
A
P
240
241
D
S
L
F
H
Q
S
E
L
S
F
A
P
L
R
G
I
P
D
K
S
E
D
T
E
W
S
S
R
P
S
E
V
S
E
A
L
F
Q
A
T
A
E
V
A
S
D
L
A
S
S
R
F
S
V
S
Q
H
P
L
300
301
I
G
S
T
A
V
G
S
Q
C
P
F
L
P
S
E
Q
G
N
N
E
E
T
I
S
S
V
D
E
L
K
I
P
K
D
C
D
R
Y
D
D
L
C
S
Y
M
S
W
K
T
R
K
D
T
Q
W
P
E
N
N
360
361
L
A
D
K
D
Q
V
S
V
A
T
S
F
D
I
T
D
E
N
I
A
T
K
R
S
D
H
F
D
A
A
R
S
Y
G
Q
Y
W
T
Q
E
D
S
S
K
Q
A
E
T
Y
L
T
K
G
L
Q
G
K
V
E
420
421
S
D
V
I
T
L
D
G
L
N
E
N
A
V
V
C
S
E
R
V
A
E
L
Q
R
K
P
T
R
E
S
E
Y
H
S
S
D
L
R
M
L
R
M
S
P
D
T
V
P
K
A
P
K
H
L
K
A
G
D
T
480
481
S
K
G
G
I
A
K
V
T
Q
S
N
L
K
S
G
I
T
T
T
P
V
D
S
D
I
G
S
H
L
S
L
S
L
E
D
L
S
Q
L
A
V
S
S
L
E
T
T
T
G
Q
H
T
D
T
L
N
Q
K
T
540
541
L
A
D
T
H
L
T
E
E
T
L
K
V
T
A
I
P
E
P
A
D
Q
K
T
A
T
P
T
V
L
S
S
S
H
S
H
R
G
K
P
S
I
F
Y
Q
Q
G
L
P
D
S
H
L
T
E
E
A
L
K
V
600
601
S
A
A
P
G
L
A
D
Q
T
T
G
M
S
T
L
T
S
T
S
Y
S
H
R
E
K
P
G
T
F
Y
Q
Q
E
L
P
E
S
N
L
T
E
E
P
L
E
V
S
A
A
P
G
P
V
E
Q
K
T
G
I
660
661
P
T
V
S
S
T
S
H
S
H
V
E
D
L
L
F
F
Y
R
Q
T
L
P
D
G
H
L
T
D
Q
A
L
K
V
S
A
V
S
G
P
A
D
Q
K
T
G
T
A
T
V
L
S
T
P
H
S
H
R
E
K
720
721
P
G
I
F
Y
Q
Q
E
F
A
D
S
H
Q
T
E
E
T
L
T
K
V
S
A
T
P
G
P
A
D
Q
K
T
E
I
P
A
V
Q
S
S
S
Y
S
Q
R
E
K
P
S
I
L
Y
P
Q
D
L
A
D
S
780
781
H
L
P
E
E
G
L
K
V
S
A
V
A
G
P
A
D
Q
K
T
G
L
P
T
V
P
S
S
A
Y
S
H
R
E
K
L
L
V
F
Y
Q
Q
A
L
L
D
S
H
L
P
E
E
A
L
K
V
S
A
V
S
840
841
G
P
A
D
G
K
T
G
T
P
A
V
T
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900
901
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960
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1020
1021
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1080
1081
P
A
D
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M
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A
V
P
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T
F
Y
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R
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1140
1141
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1200
1201
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1260
1261
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1320
1321
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1380
1381
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L
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1440
1441
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L
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A
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L
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1500
1501
V
S
V
A
P
G
P
V
G
Q
T
T
G
A
P
T
I
T
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P
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A
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1560
1561
G
I
P
T
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T
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T
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Y
S
F
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P
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N
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1620
1621
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K
P
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L
L
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L
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1680
1681
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1740
1741
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Q
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V
1800
1801
T
S
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P
I
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S
Y
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R
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P
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I
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N
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1860
1861
E
Q
E
L
P
D
L
T
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T
L
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A
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G
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L
N
V
F
1920
1921
V
V
P
G
Q
G
D
R
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T
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P
T
V
P
L
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Y
Y
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R
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T
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A
L
K
V
S
P
V
S
I
P
A
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K
T
G
I
P
1980
1981
I
G
L
S
S
S
Y
S
H
S
H
K
E
K
L
K
I
S
T
V
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2040
2041
T
A
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N
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Q
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T
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2100
2101
N
I
F
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H
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D
V
L
K
V
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2160
2161
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D
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L
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A
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L
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N
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2220
2221
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L
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M
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A
2280
2281
P
L
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2340
2341
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2400
2401
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2460
2461
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2520
2521
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2580
2581
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L
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N
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2640
2641
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W
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2700
2701
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P
2760
2761
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D
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2820
2821
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2880
2881
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2940
2941
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R
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N
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3000
3001
K
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3060
3061
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3120
3121
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3180
3181
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3240
3241
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3360
3361
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3420
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E
N
T
T
R
S
V
F
R
S
A
K
3480
3481
F
Y
I
H
H
P
V
H
L
P
S
D
Q
D
I
C
H
E
S
L
G
K
S
V
F
M
R
H
S
W
K
D
F
F
Q
H
H
P
D
K
H
R
E
H
M
C
L
P
L
P
Y
Q
N
M
D
K
T
K
T
D
3540
3541
Y
T
R
I
K
S
L
S
I
N
V
N
L
G
N
K
E
V
M
D
T
T
K
S
Q
V
R
D
Y
P
K
H
N
G
Q
I
S
D
P
Q
R
D
Q
K
V
T
P
E
Q
T
T
Q
H
T
V
S
L
N
E
L
3600
3601
W
N
K
Y
R
E
R
Q
R
Q
Q
R
Q
P
E
L
G
D
R
K
E
L
S
L
V
D
R
L
D
R
L
A
K
I
L
Q
N
P
I
T
H
S
L
Q
V
S
E
S
T
H
D
D
S
R
G
E
R
S
V
K
3660
3661
E
W
S
G
R
Q
Q
Q
R
N
K
L
Q
K
K
K
R
F
K
S
L
E
K
S
H
K
N
T
G
E
L
K
K
S
K
V
L
S
H
H
R
A
G
R
S
N
Q
I
K
I
E
Q
I
K
F
D
K
Y
I
L
3720
3721
S
K
Q
P
G
F
N
Y
I
S
N
T
S
S
D
C
R
P
S
E
E
S
E
L
L
T
D
T
T
T
N
I
L
S
G
T
T
S
T
V
E
S
D
I
L
T
Q
T
D
R
E
V
A
L
H
E
R
S
S
S
3780
3781
V
S
T
I
D
T
A
R
L
I
Q
A
F
G
H
E
R
V
C
L
S
P
R
R
I
K
L
Y
S
S
I
T
N
Q
Q
R
R
Y
L
E
K
R
S
K
H
S
K
K
V
L
N
T
G
H
P
L
V
T
S
E
3840
3841
H
T
R
R
R
H
I
Q
V
A
N
H
V
I
S
S
D
S
I
S
S
S
A
S
S
F
L
S
S
N
S
T
F
C
N
K
Q
N
V
H
M
L
N
K
G
I
Q
A
G
N
L
E
I
V
N
G
A
K
K
H
3900
3901
T
R
D
V
G
I
T
F
P
T
P
S
S
S
E
A
K
L
E
E
N
S
D
V
T
S
W
S
E
E
K
R
E
E
K
M
L
F
T
G
Y
P
E
D
R
K
L
K
K
N
K
K
N
S
H
E
G
V
S
W
3960
3961
F
V
P
V
E
N
V
E
S
R
S
K
K
E
N
V
P
N
T
C
G
P
G
I
S
W
F
E
P
I
T
K
T
R
P
W
R
E
P
L
R
E
Q
N
C
Q
G
Q
H
L
D
G
R
G
Y
L
A
G
P
G
4020
4021
R
E
A
G
R
D
L
L
R
P
F
V
R
A
T
L
Q
E
S
L
Q
F
H
R
P
D
F
I
S
R
S
G
E
R
I
K
R
L
K
L
I
V
Q
E
R
K
L
Q
S
M
L
Q
T
E
R
D
A
L
F
N
4080
4081
I
D
R
E
R
Q
G
H
Q
N
R
M
C
P
L
P
K
R
V
F
L
A
I
Q
K
N
K
P
I
S
K
K
E
M
I
Q
R
S
K
R
I
Y
E
Q
L
P
E
V
Q
K
K
R
E
E
E
K
R
K
S
E
4140
4141
Y
K
S
Y
R
L
R
A
Q
L
Y
K
K
R
V
T
N
Q
L
L
G
R
K
V
P
W
D
4167
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0647
Peptide:
LVFYQQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8TCU4
UniProt Name:
ALMS1_HUMAN
Protein Name:
Alstrom syndrome protein 1
Position:
817-822
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.76
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.5
Area of the profile Above Threshold (AGGRESCAN):
3.56
Best Energy Score (PASTA 2.0):
-4.08
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0648 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0648
Peptide:
LVHSSN
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
49-54
Literature
PMID:
26629790
Reference:
J Phys Chem B. 2016 Jul 7;120(26):5810-6.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.5
Area of the profile Above Threshold (AGGRESCAN):
0.35
Best Energy Score (PASTA 2.0):
-2.01
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0649 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0649
Peptide:
LVSSSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
146-151
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.0
Area of the profile Above Threshold (AGGRESCAN):
0.92
Best Energy Score (PASTA 2.0):
-1.43
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0650 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0650
Peptide:
LVTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39V
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.02
Tango:
60.62
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
77.1
Area of the profile Above Threshold (AGGRESCAN):
5.03
Best Energy Score (PASTA 2.0):
-7.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0651 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0651
Peptide:
LWTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39W
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.98
Tango:
47.65
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
69.7
Area of the profile Above Threshold (AGGRESCAN):
4.53
Best Energy Score (PASTA 2.0):
-6.18
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0652 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0652
Peptide:
LYQLEN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
2OMP
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
102-107
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-17.7
Area of the profile Above Threshold (AGGRESCAN):
0.86
Best Energy Score (PASTA 2.0):
-0.57
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0653 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0653
Peptide:
LYTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39Y
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.92
Tango:
19.19
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
71.3
Area of the profile Above Threshold (AGGRESCAN):
4.64
Best Energy Score (PASTA 2.0):
-5.71
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0654 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0654
Peptide:
LYVLIV
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q99679
UniProt Name:
GPR21_HUMAN
Protein Name:
Probable G-protein coupled receptor 21
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.08
Tango:
302.69
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
110.9
Area of the profile Above Threshold (AGGRESCAN):
7.17
Best Energy Score (PASTA 2.0):
-7.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0655 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0655
Peptide:
MAAAQA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
323-328
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-27.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0656 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0656
Peptide:
MATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38M
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.31
Tango:
1.37
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
50.7
Area of the profile Above Threshold (AGGRESCAN):
3.24
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0657 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0657
Peptide:
MCSIFQ
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q12887
UniProt Name:
COX10_HUMAN
Protein Name:
Protoheme IX farnesyltransferase
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.7
Area of the profile Above Threshold (AGGRESCAN):
2.72
Best Energy Score (PASTA 2.0):
-2.5
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0658 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0658
Peptide:
MERLRI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1304-1309
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.08
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0659 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
P
A
R
F
A
G
V
L
L
A
L
A
L
I
L
P
G
T
L
C
A
E
G
T
R
G
R
S
S
T
A
R
C
S
L
F
G
S
D
F
V
N
T
F
D
G
S
M
Y
S
F
A
G
Y
C
S
Y
L
60
61
L
A
G
G
C
Q
K
R
S
F
S
I
I
G
D
F
Q
N
G
K
R
V
S
L
S
V
Y
L
G
E
F
F
D
I
H
L
F
V
N
G
T
V
T
Q
G
D
Q
R
V
S
M
P
Y
A
S
K
G
L
Y
L
120
121
E
T
E
A
G
Y
Y
K
L
S
G
E
A
Y
G
F
V
A
R
I
D
G
S
G
N
F
Q
V
L
L
S
D
R
Y
F
N
K
T
C
G
L
C
G
N
F
N
I
F
A
E
D
D
F
M
T
Q
E
G
T
L
180
181
T
S
D
P
Y
D
F
A
N
S
W
A
L
S
S
G
E
Q
W
C
E
R
A
S
P
P
S
S
S
C
N
I
S
S
G
E
M
Q
K
G
L
W
E
Q
C
Q
L
L
K
S
T
S
V
F
A
R
C
H
P
L
240
241
V
D
P
E
P
F
V
A
L
C
E
K
T
L
C
E
C
A
G
G
L
E
C
A
C
P
A
L
L
E
Y
A
R
T
C
A
Q
E
G
M
V
L
Y
G
W
T
D
H
S
A
C
S
P
V
C
P
A
G
M
E
300
301
Y
R
Q
C
V
S
P
C
A
R
T
C
Q
S
L
H
I
N
E
M
C
Q
E
R
C
V
D
G
C
S
C
P
E
G
Q
L
L
D
E
G
L
C
V
E
S
T
E
C
P
C
V
H
S
G
K
R
Y
P
P
G
360
361
T
S
L
S
R
D
C
N
T
C
I
C
R
N
S
Q
W
I
C
S
N
E
E
C
P
G
E
C
L
V
T
G
Q
S
H
F
K
S
F
D
N
R
Y
F
T
F
S
G
I
C
Q
Y
L
L
A
R
D
C
Q
D
420
421
H
S
F
S
I
V
I
E
T
V
Q
C
A
D
D
R
D
A
V
C
T
R
S
V
T
V
R
L
P
G
L
H
N
S
L
V
K
L
K
H
G
A
G
V
A
M
D
G
Q
D
V
Q
L
P
L
L
K
G
D
L
480
481
R
I
Q
H
T
V
T
A
S
V
R
L
S
Y
G
E
D
L
Q
M
D
W
D
G
R
G
R
L
L
V
K
L
S
P
V
Y
A
G
K
T
C
G
L
C
G
N
Y
N
G
N
Q
G
D
D
F
L
T
P
S
G
540
541
L
A
E
P
R
V
E
D
F
G
N
A
W
K
L
H
G
D
C
Q
D
L
Q
K
Q
H
S
D
P
C
A
L
N
P
R
M
T
R
F
S
E
E
A
C
A
V
L
T
S
P
T
F
E
A
C
H
R
A
V
S
600
601
P
L
P
Y
L
R
N
C
R
Y
D
V
C
S
C
S
D
G
R
E
C
L
C
G
A
L
A
S
Y
A
A
A
C
A
G
R
G
V
R
V
A
W
R
E
P
G
R
C
E
L
N
C
P
K
G
Q
V
Y
L
Q
660
661
C
G
T
P
C
N
L
T
C
R
S
L
S
Y
P
D
E
E
C
N
E
A
C
L
E
G
C
F
C
P
P
G
L
Y
M
D
E
R
G
D
C
V
P
K
A
Q
C
P
C
Y
Y
D
G
E
I
F
Q
P
E
D
720
721
I
F
S
D
H
H
T
M
C
Y
C
E
D
G
F
M
H
C
T
M
S
G
V
P
G
S
L
L
P
D
A
V
L
S
S
P
L
S
H
R
S
K
R
S
L
S
C
R
P
P
M
V
K
L
V
C
P
A
D
N
780
781
L
R
A
E
G
L
E
C
T
K
T
C
Q
N
Y
D
L
E
C
M
S
M
G
C
V
S
G
C
L
C
P
P
G
M
V
R
H
E
N
R
C
V
A
L
E
R
C
P
C
F
H
Q
G
K
E
Y
A
P
G
E
840
841
T
V
K
I
G
C
N
T
C
V
C
Q
D
R
K
W
N
C
T
D
H
V
C
D
A
T
C
S
T
I
G
M
A
H
Y
L
T
F
D
G
L
K
Y
L
F
P
G
E
C
Q
Y
V
L
V
Q
D
Y
C
G
S
900
901
N
P
G
T
F
R
I
L
V
G
N
K
G
C
S
H
P
S
V
K
C
K
K
R
V
T
I
L
V
E
G
G
E
I
E
L
F
D
G
E
V
N
V
K
R
P
M
K
D
E
T
H
F
E
V
V
E
S
G
R
960
961
Y
I
I
L
L
L
G
K
A
L
S
V
V
W
D
R
H
L
S
I
S
V
V
L
K
Q
T
Y
Q
E
K
V
C
G
L
C
G
N
F
D
G
I
Q
N
N
D
L
T
S
S
N
L
Q
V
E
E
D
P
V
D
1020
1021
F
G
N
S
W
K
V
S
S
Q
C
A
D
T
R
K
V
P
L
D
S
S
P
A
T
C
H
N
N
I
M
K
Q
T
M
V
D
S
S
C
R
I
L
T
S
D
V
F
Q
D
C
N
K
L
V
D
P
E
P
Y
1080
1081
L
D
V
C
I
Y
D
T
C
S
C
E
S
I
G
D
C
A
C
F
C
D
T
I
A
A
Y
A
H
V
C
A
Q
H
G
K
V
V
T
W
R
T
A
T
L
C
P
Q
S
C
E
E
R
N
L
R
E
N
G
Y
1140
1141
E
C
E
W
R
Y
N
S
C
A
P
A
C
Q
V
T
C
Q
H
P
E
P
L
A
C
P
V
Q
C
V
E
G
C
H
A
H
C
P
P
G
K
I
L
D
E
L
L
Q
T
C
V
D
P
E
D
C
P
V
C
E
1200
1201
V
A
G
R
R
F
A
S
G
K
K
V
T
L
N
P
S
D
P
E
H
C
Q
I
C
H
C
D
V
V
N
L
T
C
E
A
C
Q
E
P
G
G
L
V
V
P
P
T
D
A
P
V
S
P
T
T
L
Y
V
E
1260
1261
D
I
S
E
P
P
L
H
D
F
Y
C
S
R
L
L
D
L
V
F
L
L
D
G
S
S
R
L
S
E
A
E
F
E
V
L
K
A
F
V
V
D
M
M
E
R
L
R
I
S
Q
K
W
V
R
V
A
V
V
E
1320
1321
Y
H
D
G
S
H
A
Y
I
G
L
K
D
R
K
R
P
S
E
L
R
R
I
A
S
Q
V
K
Y
A
G
S
Q
V
A
S
T
S
E
V
L
K
Y
T
L
F
Q
I
F
S
K
I
D
R
P
E
A
S
R
I
1380
1381
T
L
L
L
M
A
S
Q
E
P
Q
R
M
S
R
N
F
V
R
Y
V
Q
G
L
K
K
K
K
V
I
V
I
P
V
G
I
G
P
H
A
N
L
K
Q
I
R
L
I
E
K
Q
A
P
E
N
K
A
F
V
L
1440
1441
S
S
V
D
E
L
E
Q
Q
R
D
E
I
V
S
Y
L
C
D
L
A
P
E
A
P
P
P
T
L
P
P
D
M
A
Q
V
T
V
G
P
G
L
L
G
V
S
T
L
G
P
K
R
N
S
M
V
L
D
V
A
1500
1501
F
V
L
E
G
S
D
K
I
G
E
A
D
F
N
R
S
K
E
F
M
E
E
V
I
Q
R
M
D
V
G
Q
D
S
I
H
V
T
V
L
Q
Y
S
Y
M
V
T
V
E
Y
P
F
S
E
A
Q
S
K
G
D
1560
1561
I
L
Q
R
V
R
E
I
R
Y
Q
G
G
N
R
T
N
T
G
L
A
L
R
Y
L
S
D
H
S
F
L
V
S
Q
G
D
R
E
Q
A
P
N
L
V
Y
M
V
T
G
N
P
A
S
D
E
I
K
R
L
P
1620
1621
G
D
I
Q
V
V
P
I
G
V
G
P
N
A
N
V
Q
E
L
E
R
I
G
W
P
N
A
P
I
L
I
Q
D
F
E
T
L
P
R
E
A
P
D
L
V
L
Q
R
C
C
S
G
E
G
L
Q
I
P
T
L
1680
1681
S
P
A
P
D
C
S
Q
P
L
D
V
I
L
L
L
D
G
S
S
S
F
P
A
S
Y
F
D
E
M
K
S
F
A
K
A
F
I
S
K
A
N
I
G
P
R
L
T
Q
V
S
V
L
Q
Y
G
S
I
T
T
1740
1741
I
D
V
P
W
N
V
V
P
E
K
A
H
L
L
S
L
V
D
V
M
Q
R
E
G
G
P
S
Q
I
G
D
A
L
G
F
A
V
R
Y
L
T
S
E
M
H
G
A
R
P
G
A
S
K
A
V
V
I
L
V
1800
1801
T
D
V
S
V
D
S
V
D
A
A
A
D
A
A
R
S
N
R
V
T
V
F
P
I
G
I
G
D
R
Y
D
A
A
Q
L
R
I
L
A
G
P
A
G
D
S
N
V
V
K
L
Q
R
I
E
D
L
P
T
M
1860
1861
V
T
L
G
N
S
F
L
H
K
L
C
S
G
F
V
R
I
C
M
D
E
D
G
N
E
K
R
P
G
D
V
W
T
L
P
D
Q
C
H
T
V
T
C
Q
P
D
G
Q
T
L
L
K
S
H
R
V
N
C
D
1920
1921
R
G
L
R
P
S
C
P
N
S
Q
S
P
V
K
V
E
E
T
C
G
C
R
W
T
C
P
C
V
C
T
G
S
S
T
R
H
I
V
T
F
D
G
Q
N
F
K
L
T
G
S
C
S
Y
V
L
F
Q
N
K
1980
1981
E
Q
D
L
E
V
I
L
H
N
G
A
C
S
P
G
A
R
Q
G
C
M
K
S
I
E
V
K
H
S
A
L
S
V
E
L
H
S
D
M
E
V
T
V
N
G
R
L
V
S
V
P
Y
V
G
G
N
M
E
V
2040
2041
N
V
Y
G
A
I
M
H
E
V
R
F
N
H
L
G
H
I
F
T
F
T
P
Q
N
N
E
F
Q
L
Q
L
S
P
K
T
F
A
S
K
T
Y
G
L
C
G
I
C
D
E
N
G
A
N
D
F
M
L
R
D
2100
2101
G
T
V
T
T
D
W
K
T
L
V
Q
E
W
T
V
Q
R
P
G
Q
T
C
Q
P
I
L
E
E
Q
C
L
V
P
D
S
S
H
C
Q
V
L
L
L
P
L
F
A
E
C
H
K
V
L
A
P
A
T
F
Y
2160
2161
A
I
C
Q
Q
D
S
C
H
Q
E
Q
V
C
E
V
I
A
S
Y
A
H
L
C
R
T
N
G
V
C
V
D
W
R
T
P
D
F
C
A
M
S
C
P
P
S
L
V
Y
N
H
C
E
H
G
C
P
R
H
C
2220
2221
D
G
N
V
S
S
C
G
D
H
P
S
E
G
C
F
C
P
P
D
K
V
M
L
E
G
S
C
V
P
E
E
A
C
T
Q
C
I
G
E
D
G
V
Q
H
Q
F
L
E
A
W
V
P
D
H
Q
P
C
Q
I
2280
2281
C
T
C
L
S
G
R
K
V
N
C
T
T
Q
P
C
P
T
A
K
A
P
T
C
G
L
C
E
V
A
R
L
R
Q
N
A
D
Q
C
C
P
E
Y
E
C
V
C
D
P
V
S
C
D
L
P
P
V
P
H
C
2340
2341
E
R
G
L
Q
P
T
L
T
N
P
G
E
C
R
P
N
F
T
C
A
C
R
K
E
E
C
K
R
V
S
P
P
S
C
P
P
H
R
L
P
T
L
R
K
T
Q
C
C
D
E
Y
E
C
A
C
N
C
V
N
2400
2401
S
T
V
S
C
P
L
G
Y
L
A
S
T
A
T
N
D
C
G
C
T
T
T
T
C
L
P
D
K
V
C
V
H
R
S
T
I
Y
P
V
G
Q
F
W
E
E
G
C
D
V
C
T
C
T
D
M
E
D
A
V
2460
2461
M
G
L
R
V
A
Q
C
S
Q
K
P
C
E
D
S
C
R
S
G
F
T
Y
V
L
H
E
G
E
C
C
G
R
C
L
P
S
A
C
E
V
V
T
G
S
P
R
G
D
S
Q
S
S
W
K
S
V
G
S
Q
2520
2521
W
A
S
P
E
N
P
C
L
I
N
E
C
V
R
V
K
E
E
V
F
I
Q
Q
R
N
V
S
C
P
Q
L
E
V
P
V
C
P
S
G
F
Q
L
S
C
K
T
S
A
C
C
P
S
C
R
C
E
R
M
E
2580
2581
A
C
M
L
N
G
T
V
I
G
P
G
K
T
V
M
I
D
V
C
T
T
C
R
C
M
V
Q
V
G
V
I
S
G
F
K
L
E
C
R
K
T
T
C
N
P
C
P
L
G
Y
K
E
E
N
N
T
G
E
C
2640
2641
C
G
R
C
L
P
T
A
C
T
I
Q
L
R
G
G
Q
I
M
T
L
K
R
D
E
T
L
Q
D
G
C
D
T
H
F
C
K
V
N
E
R
G
E
Y
F
W
E
K
R
V
T
G
C
P
P
F
D
E
H
K
2700
2701
C
L
A
E
G
G
K
I
M
K
I
P
G
T
C
C
D
T
C
E
E
P
E
C
N
D
I
T
A
R
L
Q
Y
V
K
V
G
S
C
K
S
E
V
E
V
D
I
H
Y
C
Q
G
K
C
A
S
K
A
M
Y
2760
2761
S
I
D
I
N
D
V
Q
D
Q
C
S
C
C
S
P
T
R
T
E
P
M
Q
V
A
L
H
C
T
N
G
S
V
V
Y
H
E
V
L
N
A
M
E
C
K
C
S
P
R
K
C
S
K
2813
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0659
Peptide:
MEWLRI
Length:
6
Classification:
Non-amyloid
Mutation(s):
R1306W
Structure(s):
No structures
Protein Information
UniProt ID:
P04275
UniProt Name:
VWF_HUMAN
Protein Name:
von Willebrand factor (vWF)
Position:
1304-1309
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
-0.08
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
22.2
Area of the profile Above Threshold (AGGRESCAN):
1.49
Best Energy Score (PASTA 2.0):
-2.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0660 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0660
Peptide:
MGGGMN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
307-312
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.4
Area of the profile Above Threshold (AGGRESCAN):
0.06
Best Energy Score (PASTA 2.0):
2.06
Aggregate Orientation (PASTA 2.0):
Antiparallel
