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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 601 to 630 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0601
LINNSV
6
Non-amyloid
G protein-coupled receptor GPR1
Q12361
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0602
LITVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39I
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0603
LIVAAD
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0604
LIVAGD
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0605
LIVAGE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0606
LIVAGK
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0607
LIVAGS
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0608
LIVAGT
6
Amyloid
No
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
21205900
Waltz-DB 2.0, AmyLoad
P-0609
LKLVSS
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0610
LKNGER
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0611
LKTVYV
6
non-amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39K
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0612
LKVKVL
6
amyloid
Alpha-crystallin B chain
P02511
No
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
23552370
Waltz-DB 2.0
P-0613
LLAVVA
6
amyloid
Minor curlin subunit
P0ABK7
No
J Struct Biol. 2016 Aug;195(2):179-189.
27245712
Waltz-DB 2.0
P-0614
LLFCHI
6
Non-amyloid
Coagulation factor VIII
P00451
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0615
LLFYHI
6
Non-amyloid
Coagulation factor VIII
P00451
C329F
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0616
LLGPTI
6
Non-amyloid
Coagulation factor VIII
P00451
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0617
LLNKTN
6
Non-amyloid
[NU+] prion formation protein 1
Q08972
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0618
LLTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39L
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0619
LLVPTI
6
Non-amyloid
Coagulation factor VIII
P00451
G92V
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0620
LLYYTE
6
Amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0621
LMNTTN
6
Non-amyloid
Nitrogen regulatory protein GLN3
P18494
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0622
LMSLFG
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0623
LMTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39M
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0624
LNDFQK
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0625
LNIYQY
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0626
LNNITA
6
Non-amyloid
G protein-coupled receptor GPR1
Q12361
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0627
LNTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39N
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0628
LPKVED
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0629
LPTVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
A39P
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0630
LQGYQA
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0601 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
T
E
G
F
P
P
N
L
N
A
L
K
G
S
S
L
L
E
K
R
V
D
S
L
R
Q
L
N
T
T
T
V
N
Q
L
L
G
L
P
G
M
T
S
T
F
T
A
P
Q
L
L
Q
L
R
I
I
A
I
60
61
T
A
S
A
V
S
L
I
A
G
C
L
G
M
F
F
L
S
K
M
D
K
R
R
K
V
F
R
H
D
L
I
A
F
L
I
I
C
D
F
L
K
A
F
I
L
M
I
Y
P
M
I
I
L
I
N
N
S
V
Y
120
121
A
T
P
A
F
F
N
T
L
G
W
F
T
A
F
A
I
E
G
A
D
M
A
I
M
I
F
A
I
H
F
A
I
L
I
F
K
P
N
W
K
W
R
N
K
R
S
G
N
M
E
G
G
L
Y
K
K
R
S
Y
180
181
I
W
P
I
T
A
L
V
P
A
I
L
A
S
L
A
F
I
N
Y
N
K
L
N
D
D
S
D
T
T
I
I
L
D
N
N
N
Y
N
F
P
D
S
P
R
Q
G
G
Y
K
P
W
S
A
W
C
Y
L
P
P
240
241
K
P
Y
W
Y
K
I
V
L
S
W
G
P
R
Y
F
I
I
I
F
I
F
A
V
Y
L
S
I
Y
I
F
I
T
S
E
S
K
R
I
K
A
Q
I
G
D
F
N
H
N
V
L
E
E
E
K
E
K
K
K
L
300
301
F
G
L
G
H
W
G
K
A
K
W
Y
F
R
S
Y
F
K
L
P
L
L
H
L
L
R
N
L
K
N
F
F
T
I
S
F
I
D
P
N
E
E
T
D
D
S
G
S
S
N
G
T
F
N
F
G
E
S
S
N
360
361
E
I
P
T
L
F
R
K
T
N
T
G
S
D
E
N
V
S
A
S
G
G
V
R
L
L
D
Y
N
S
A
K
P
L
D
M
S
K
Y
A
M
S
E
Q
P
D
L
E
R
N
N
P
F
D
C
E
N
D
I
T
420
421
L
N
P
S
E
L
V
S
K
Q
K
E
H
K
V
T
F
S
V
E
N
E
G
L
D
T
R
K
S
S
M
L
G
H
Q
T
F
S
C
Q
N
S
L
E
S
P
L
A
M
Y
D
N
K
N
D
N
S
D
I
T
480
481
S
N
I
K
E
K
G
G
I
I
N
N
N
S
N
N
D
D
D
D
N
N
N
N
N
D
N
D
N
D
N
N
N
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
540
541
N
N
N
N
S
N
N
I
K
N
N
V
D
N
N
N
T
N
P
A
D
N
I
P
T
L
S
N
E
A
F
T
P
S
Q
Q
F
S
Q
E
R
V
N
N
N
A
D
R
C
E
N
S
S
F
T
N
V
Q
Q
H
600
601
F
Q
A
Q
T
Y
K
Q
M
K
K
R
R
A
Q
I
Q
K
N
L
R
A
I
F
I
Y
P
L
S
Y
I
G
I
W
L
F
P
I
I
A
D
A
L
Q
Y
N
H
E
I
K
H
G
P
T
M
W
V
T
Y
I
660
661
D
T
C
V
R
P
L
S
C
L
V
D
V
I
V
Y
L
F
K
E
K
P
W
N
Y
S
W
A
K
T
E
S
K
Y
L
I
E
K
Y
I
L
K
G
E
L
G
E
K
E
I
L
K
F
C
H
S
N
W
G
K
720
721
R
G
W
Y
Y
R
G
K
W
K
K
R
K
C
W
K
Y
S
T
N
P
L
K
R
I
L
W
F
V
E
R
F
F
K
Q
L
F
E
L
K
L
H
F
S
F
Y
D
N
C
D
D
F
E
Y
W
E
N
Y
Y
S
780
781
A
K
D
S
N
D
N
K
R
T
E
S
D
E
T
K
T
N
S
S
D
R
S
L
P
S
N
S
L
E
L
Q
A
M
L
N
N
I
T
A
E
E
V
E
V
P
L
F
W
R
I
I
H
H
I
P
M
L
G
G
840
841
I
D
L
D
E
L
N
R
L
L
K
I
R
Y
N
N
D
H
F
S
L
P
G
L
K
F
A
L
N
Q
N
K
S
H
D
K
H
Q
D
V
S
T
N
S
M
V
K
S
S
F
F
S
S
N
I
V
T
N
D
D
900
901
E
N
S
I
E
E
D
K
N
L
R
Y
S
D
A
S
A
S
E
N
Y
L
V
K
P
T
I
P
G
T
T
P
D
P
I
I
E
A
Q
N
D
N
D
S
S
D
S
S
G
I
D
L
I
A
F
L
R
N
G
P
960
961
L
961
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0601
Peptide:
LINNSV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12361
UniProt Name:
GPR1_YEAST
Protein Name:
G protein-coupled receptor GPR1
Position:
114-119
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.72
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.0
Area of the profile Above Threshold (AGGRESCAN):
0.2
Best Energy Score (PASTA 2.0):
-4.02
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0602 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0602
Peptide:
LITVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39I
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.04
Tango:
57.87
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
80.1
Area of the profile Above Threshold (AGGRESCAN):
5.24
Best Energy Score (PASTA 2.0):
-7.25
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0603 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0603
Peptide:
LIVAAD
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
83.33
NuAPRpred:
0.34
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
32.4
Area of the profile Above Threshold (AGGRESCAN):
2.9
Best Energy Score (PASTA 2.0):
-4.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0604 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0604
Peptide:
LIVAGD
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.3
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
25.7
Area of the profile Above Threshold (AGGRESCAN):
2.7
Best Energy Score (PASTA 2.0):
-4.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0605 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0605
Peptide:
LIVAGE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
29.9
Area of the profile Above Threshold (AGGRESCAN):
2.79
Best Energy Score (PASTA 2.0):
-4.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0606 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0606
Peptide:
LIVAGK
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.32
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
34.7
Area of the profile Above Threshold (AGGRESCAN):
2.89
Best Energy Score (PASTA 2.0):
-4.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0607 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0607
Peptide:
LIVAGS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.72
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
41.1
Area of the profile Above Threshold (AGGRESCAN):
3.01
Best Energy Score (PASTA 2.0):
-4.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0608 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0608
Peptide:
LIVAGT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
21205900
Reference:
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1361-6.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
42.5
Area of the profile Above Threshold (AGGRESCAN):
3.04
Best Energy Score (PASTA 2.0):
-4.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0609 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0609
Peptide:
LKLVSS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
144-149
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.9
Area of the profile Above Threshold (AGGRESCAN):
2.47
Best Energy Score (PASTA 2.0):
-2.18
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0610 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0610
Peptide:
LKNGER
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
60-65
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.28
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-84.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.94
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0611 Classification: non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0611
Peptide:
LKTVYV
Length:
6
Classification:
non-amyloid
Mutation(s):
A39K
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.38
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
43.4
Area of the profile Above Threshold (AGGRESCAN):
2.76
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0612 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
D
I
A
I
H
H
P
W
I
R
R
P
F
F
P
F
H
S
P
S
R
L
F
D
Q
F
F
G
E
H
L
L
E
S
D
L
F
P
T
S
T
S
L
S
P
F
Y
L
R
P
P
S
F
L
R
A
P
S
W
60
61
F
D
T
G
L
S
E
M
R
L
E
K
D
R
F
S
V
N
L
D
V
K
H
F
S
P
E
E
L
K
V
K
V
L
G
D
V
I
E
V
H
G
K
H
E
E
R
Q
D
E
H
G
F
I
S
R
E
F
H
R
120
121
K
Y
R
I
P
A
D
V
D
P
L
T
I
T
S
S
L
S
S
D
G
V
L
T
V
N
G
P
R
K
Q
V
S
G
P
E
R
T
I
P
I
T
R
E
E
K
P
A
V
T
A
A
P
K
K
175
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0612
Peptide:
LKVKVL
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02511
UniProt Name:
CRYAB_HUMAN
Protein Name:
Alpha-crystallin B chain
Position:
89-94
Literature
PMID:
23552370
Reference:
Sci Transl Med. 2013 Apr 3;5(179):179ra42.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
31.6
Area of the profile Above Threshold (AGGRESCAN):
2.18
Best Energy Score (PASTA 2.0):
-3.43
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0613 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
N
K
L
L
F
M
M
L
T
I
L
G
A
P
G
I
A
A
A
A
G
Y
D
L
A
N
S
E
Y
N
F
A
V
N
E
L
S
K
S
S
F
N
Q
A
A
I
I
G
Q
A
G
T
N
N
S
A
Q
L
60
61
R
Q
G
G
S
K
L
L
A
V
V
A
Q
E
G
S
S
N
R
A
K
I
D
Q
T
G
D
Y
N
L
A
Y
I
D
Q
A
G
S
A
N
D
A
S
I
S
Q
G
A
Y
G
N
T
A
M
I
I
Q
K
G
S
120
121
G
N
K
A
N
I
T
Q
Y
G
T
Q
K
T
A
I
V
V
Q
R
Q
S
Q
M
A
I
R
V
T
Q
R
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0613
Peptide:
LLAVVA
Length:
6
Classification:
amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P0ABK7
UniProt Name:
CSGB_ECOLI
Protein Name:
Minor curlin subunit
Position:
67-72
Literature
PMID:
27245712
Reference:
J Struct Biol. 2016 Aug;195(2):179-189.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.0
Tango:
11.83
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
66.2
Area of the profile Above Threshold (AGGRESCAN):
4.37
Best Energy Score (PASTA 2.0):
-5.02
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0614 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
I
E
L
S
T
C
F
F
L
C
L
L
R
F
C
F
S
A
T
R
R
Y
Y
L
G
A
V
E
L
S
W
D
Y
M
Q
S
D
L
G
E
L
P
V
D
A
R
F
P
P
R
V
P
K
S
F
P
F
N
60
61
T
S
V
V
Y
K
K
T
L
F
V
E
F
T
D
H
L
F
N
I
A
K
P
R
P
P
W
M
G
L
L
G
P
T
I
Q
A
E
V
Y
D
T
V
V
I
T
L
K
N
M
A
S
H
P
V
S
L
H
A
V
120
121
G
V
S
Y
W
K
A
S
E
G
A
E
Y
D
D
Q
T
S
Q
R
E
K
E
D
D
K
V
F
P
G
G
S
H
T
Y
V
W
Q
V
L
K
E
N
G
P
M
A
S
D
P
L
C
L
T
Y
S
Y
L
S
H
180
181
V
D
L
V
K
D
L
N
S
G
L
I
G
A
L
L
V
C
R
E
G
S
L
A
K
E
K
T
Q
T
L
H
K
F
I
L
L
F
A
V
F
D
E
G
K
S
W
H
S
E
T
K
N
S
L
M
Q
D
R
D
240
241
A
A
S
A
R
A
W
P
K
M
H
T
V
N
G
Y
V
N
R
S
L
P
G
L
I
G
C
H
R
K
S
V
Y
W
H
V
I
G
M
G
T
T
P
E
V
H
S
I
F
L
E
G
H
T
F
L
V
R
N
H
300
301
R
Q
A
S
L
E
I
S
P
I
T
F
L
T
A
Q
T
L
L
M
D
L
G
Q
F
L
L
F
C
H
I
S
S
H
Q
H
D
G
M
E
A
Y
V
K
V
D
S
C
P
E
E
P
Q
L
R
M
K
N
N
E
360
361
E
A
E
D
Y
D
D
D
L
T
D
S
E
M
D
V
V
R
F
D
D
D
N
S
P
S
F
I
Q
I
R
S
V
A
K
K
H
P
K
T
W
V
H
Y
I
A
A
E
E
E
D
W
D
Y
A
P
L
V
L
A
420
421
P
D
D
R
S
Y
K
S
Q
Y
L
N
N
G
P
Q
R
I
G
R
K
Y
K
K
V
R
F
M
A
Y
T
D
E
T
F
K
T
R
E
A
I
Q
H
E
S
G
I
L
G
P
L
L
Y
G
E
V
G
D
T
L
480
481
L
I
I
F
K
N
Q
A
S
R
P
Y
N
I
Y
P
H
G
I
T
D
V
R
P
L
Y
S
R
R
L
P
K
G
V
K
H
L
K
D
F
P
I
L
P
G
E
I
F
K
Y
K
W
T
V
T
V
E
D
G
P
540
541
T
K
S
D
P
R
C
L
T
R
Y
Y
S
S
F
V
N
M
E
R
D
L
A
S
G
L
I
G
P
L
L
I
C
Y
K
E
S
V
D
Q
R
G
N
Q
I
M
S
D
K
R
N
V
I
L
F
S
V
F
D
E
600
601
N
R
S
W
Y
L
T
E
N
I
Q
R
F
L
P
N
P
A
G
V
Q
L
E
D
P
E
F
Q
A
S
N
I
M
H
S
I
N
G
Y
V
F
D
S
L
Q
L
S
V
C
L
H
E
V
A
Y
W
Y
I
L
S
660
661
I
G
A
Q
T
D
F
L
S
V
F
F
S
G
Y
T
F
K
H
K
M
V
Y
E
D
T
L
T
L
F
P
F
S
G
E
T
V
F
M
S
M
E
N
P
G
L
W
I
L
G
C
H
N
S
D
F
R
N
R
G
720
721
M
T
A
L
L
K
V
S
S
C
D
K
N
T
G
D
Y
Y
E
D
S
Y
E
D
I
S
A
Y
L
L
S
K
N
N
A
I
E
P
R
S
F
S
Q
N
S
R
H
P
S
T
R
Q
K
Q
F
N
A
T
T
I
780
781
P
E
N
D
I
E
K
T
D
P
W
F
A
H
R
T
P
M
P
K
I
Q
N
V
S
S
S
D
L
L
M
L
L
R
Q
S
P
T
P
H
G
L
S
L
S
D
L
Q
E
A
K
Y
E
T
F
S
D
D
P
S
840
841
P
G
A
I
D
S
N
N
S
L
S
E
M
T
H
F
R
P
Q
L
H
H
S
G
D
M
V
F
T
P
E
S
G
L
Q
L
R
L
N
E
K
L
G
T
T
A
A
T
E
L
K
K
L
D
F
K
V
S
S
T
900
901
S
N
N
L
I
S
T
I
P
S
D
N
L
A
A
G
T
D
N
T
S
S
L
G
P
P
S
M
P
V
H
Y
D
S
Q
L
D
T
T
L
F
G
K
K
S
S
P
L
T
E
S
G
G
P
L
S
L
S
E
E
960
961
N
N
D
S
K
L
L
E
S
G
L
M
N
S
Q
E
S
S
W
G
K
N
V
S
S
T
E
S
G
R
L
F
K
G
K
R
A
H
G
P
A
L
L
T
K
D
N
A
L
F
K
V
S
I
S
L
L
K
T
N
1020
1021
K
T
S
N
N
S
A
T
N
R
K
T
H
I
D
G
P
S
L
L
I
E
N
S
P
S
V
W
Q
N
I
L
E
S
D
T
E
F
K
K
V
T
P
L
I
H
D
R
M
L
M
D
K
N
A
T
A
L
R
L
1080
1081
N
H
M
S
N
K
T
T
S
S
K
N
M
E
M
V
Q
Q
K
K
E
G
P
I
P
P
D
A
Q
N
P
D
M
S
F
F
K
M
L
F
L
P
E
S
A
R
W
I
Q
R
T
H
G
K
N
S
L
N
S
G
1140
1141
Q
G
P
S
P
K
Q
L
V
S
L
G
P
E
K
S
V
E
G
Q
N
F
L
S
E
K
N
K
V
V
V
G
K
G
E
F
T
K
D
V
G
L
K
E
M
V
F
P
S
S
R
N
L
F
L
T
N
L
D
N
1200
1201
L
H
E
N
N
T
H
N
Q
E
K
K
I
Q
E
E
I
E
K
K
E
T
L
I
Q
E
N
V
V
L
P
Q
I
H
T
V
T
G
T
K
N
F
M
K
N
L
F
L
L
S
T
R
Q
N
V
E
G
S
Y
D
1260
1261
G
A
Y
A
P
V
L
Q
D
F
R
S
L
N
D
S
T
N
R
T
K
K
H
T
A
H
F
S
K
K
G
E
E
E
N
L
E
G
L
G
N
Q
T
K
Q
I
V
E
K
Y
A
C
T
T
R
I
S
P
N
T
1320
1321
S
Q
Q
N
F
V
T
Q
R
S
K
R
A
L
K
Q
F
R
L
P
L
E
E
T
E
L
E
K
R
I
I
V
D
D
T
S
T
Q
W
S
K
N
M
K
H
L
T
P
S
T
L
T
Q
I
D
Y
N
E
K
E
1380
1381
K
G
A
I
T
Q
S
P
L
S
D
C
L
T
R
S
H
S
I
P
Q
A
N
R
S
P
L
P
I
A
K
V
S
S
F
P
S
I
R
P
I
Y
L
T
R
V
L
F
Q
D
N
S
S
H
L
P
A
A
S
Y
1440
1441
R
K
K
D
S
G
V
Q
E
S
S
H
F
L
Q
G
A
K
K
N
N
L
S
L
A
I
L
T
L
E
M
T
G
D
Q
R
E
V
G
S
L
G
T
S
A
T
N
S
V
T
Y
K
K
V
E
N
T
V
L
P
1500
1501
K
P
D
L
P
K
T
S
G
K
V
E
L
L
P
K
V
H
I
Y
Q
K
D
L
F
P
T
E
T
S
N
G
S
P
G
H
L
D
L
V
E
G
S
L
L
Q
G
T
E
G
A
I
K
W
N
E
A
N
R
P
1560
1561
G
K
V
P
F
L
R
V
A
T
E
S
S
A
K
T
P
S
K
L
L
D
P
L
A
W
D
N
H
Y
G
T
Q
I
P
K
E
E
W
K
S
Q
E
K
S
P
E
K
T
A
F
K
K
K
D
T
I
L
S
L
1620
1621
N
A
C
E
S
N
H
A
I
A
A
I
N
E
G
Q
N
K
P
E
I
E
V
T
W
A
K
Q
G
R
T
E
R
L
C
S
Q
N
P
P
V
L
K
R
H
Q
R
E
I
T
R
T
T
L
Q
S
D
Q
E
E
1680
1681
I
D
Y
D
D
T
I
S
V
E
M
K
K
E
D
F
D
I
Y
D
E
D
E
N
Q
S
P
R
S
F
Q
K
K
T
R
H
Y
F
I
A
A
V
E
R
L
W
D
Y
G
M
S
S
S
P
H
V
L
R
N
R
1740
1741
A
Q
S
G
S
V
P
Q
F
K
K
V
V
F
Q
E
F
T
D
G
S
F
T
Q
P
L
Y
R
G
E
L
N
E
H
L
G
L
L
G
P
Y
I
R
A
E
V
E
D
N
I
M
V
T
F
R
N
Q
A
S
R
1800
1801
P
Y
S
F
Y
S
S
L
I
S
Y
E
E
D
Q
R
Q
G
A
E
P
R
K
N
F
V
K
P
N
E
T
K
T
Y
F
W
K
V
Q
H
H
M
A
P
T
K
D
E
F
D
C
K
A
W
A
Y
F
S
D
V
1860
1861
D
L
E
K
D
V
H
S
G
L
I
G
P
L
L
V
C
H
T
N
T
L
N
P
A
H
G
R
Q
V
T
V
Q
E
F
A
L
F
F
T
I
F
D
E
T
K
S
W
Y
F
T
E
N
M
E
R
N
C
R
A
1920
1921
P
C
N
I
Q
M
E
D
P
T
F
K
E
N
Y
R
F
H
A
I
N
G
Y
I
M
D
T
L
P
G
L
V
M
A
Q
D
Q
R
I
R
W
Y
L
L
S
M
G
S
N
E
N
I
H
S
I
H
F
S
G
H
1980
1981
V
F
T
V
R
K
K
E
E
Y
K
M
A
L
Y
N
L
Y
P
G
V
F
E
T
V
E
M
L
P
S
K
A
G
I
W
R
V
E
C
L
I
G
E
H
L
H
A
G
M
S
T
L
F
L
V
Y
S
N
K
C
2040
2041
Q
T
P
L
G
M
A
S
G
H
I
R
D
F
Q
I
T
A
S
G
Q
Y
G
Q
W
A
P
K
L
A
R
L
H
Y
S
G
S
I
N
A
W
S
T
K
E
P
F
S
W
I
K
V
D
L
L
A
P
M
I
I
2100
2101
H
G
I
K
T
Q
G
A
R
Q
K
F
S
S
L
Y
I
S
Q
F
I
I
M
Y
S
L
D
G
K
K
W
Q
T
Y
R
G
N
S
T
G
T
L
M
V
F
F
G
N
V
D
S
S
G
I
K
H
N
I
F
N
2160
2161
P
P
I
I
A
R
Y
I
R
L
H
P
T
H
Y
S
I
R
S
T
L
R
M
E
L
M
G
C
D
L
N
S
C
S
M
P
L
G
M
E
S
K
A
I
S
D
A
Q
I
T
A
S
S
Y
F
T
N
M
F
A
2220
2221
T
W
S
P
S
K
A
R
L
H
L
Q
G
R
S
N
A
W
R
P
Q
V
N
N
P
K
E
W
L
Q
V
D
F
Q
K
T
M
K
V
T
G
V
T
T
Q
G
V
K
S
L
L
T
S
M
Y
V
K
E
F
L
2280
2281
I
S
S
S
Q
D
G
H
Q
W
T
L
F
F
Q
N
G
K
V
K
V
F
Q
G
N
Q
D
S
F
T
P
V
V
N
S
L
D
P
P
L
L
T
R
Y
L
R
I
H
P
Q
S
W
V
H
Q
I
A
L
R
M
2340
2341
E
V
L
G
C
E
A
Q
D
L
Y
2351
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0614
Peptide:
LLFCHI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00451
UniProt Name:
FA8_HUMAN
Protein Name:
Coagulation factor VIII
Position:
326-331
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.07
Tango:
1.37
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
65.7
Area of the profile Above Threshold (AGGRESCAN):
4.42
Best Energy Score (PASTA 2.0):
-4.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0615 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
I
E
L
S
T
C
F
F
L
C
L
L
R
F
C
F
S
A
T
R
R
Y
Y
L
G
A
V
E
L
S
W
D
Y
M
Q
S
D
L
G
E
L
P
V
D
A
R
F
P
P
R
V
P
K
S
F
P
F
N
60
61
T
S
V
V
Y
K
K
T
L
F
V
E
F
T
D
H
L
F
N
I
A
K
P
R
P
P
W
M
G
L
L
G
P
T
I
Q
A
E
V
Y
D
T
V
V
I
T
L
K
N
M
A
S
H
P
V
S
L
H
A
V
120
121
G
V
S
Y
W
K
A
S
E
G
A
E
Y
D
D
Q
T
S
Q
R
E
K
E
D
D
K
V
F
P
G
G
S
H
T
Y
V
W
Q
V
L
K
E
N
G
P
M
A
S
D
P
L
C
L
T
Y
S
Y
L
S
H
180
181
V
D
L
V
K
D
L
N
S
G
L
I
G
A
L
L
V
C
R
E
G
S
L
A
K
E
K
T
Q
T
L
H
K
F
I
L
L
F
A
V
F
D
E
G
K
S
W
H
S
E
T
K
N
S
L
M
Q
D
R
D
240
241
A
A
S
A
R
A
W
P
K
M
H
T
V
N
G
Y
V
N
R
S
L
P
G
L
I
G
C
H
R
K
S
V
Y
W
H
V
I
G
M
G
T
T
P
E
V
H
S
I
F
L
E
G
H
T
F
L
V
R
N
H
300
301
R
Q
A
S
L
E
I
S
P
I
T
F
L
T
A
Q
T
L
L
M
D
L
G
Q
F
L
L
F
C
H
I
S
S
H
Q
H
D
G
M
E
A
Y
V
K
V
D
S
C
P
E
E
P
Q
L
R
M
K
N
N
E
360
361
E
A
E
D
Y
D
D
D
L
T
D
S
E
M
D
V
V
R
F
D
D
D
N
S
P
S
F
I
Q
I
R
S
V
A
K
K
H
P
K
T
W
V
H
Y
I
A
A
E
E
E
D
W
D
Y
A
P
L
V
L
A
420
421
P
D
D
R
S
Y
K
S
Q
Y
L
N
N
G
P
Q
R
I
G
R
K
Y
K
K
V
R
F
M
A
Y
T
D
E
T
F
K
T
R
E
A
I
Q
H
E
S
G
I
L
G
P
L
L
Y
G
E
V
G
D
T
L
480
481
L
I
I
F
K
N
Q
A
S
R
P
Y
N
I
Y
P
H
G
I
T
D
V
R
P
L
Y
S
R
R
L
P
K
G
V
K
H
L
K
D
F
P
I
L
P
G
E
I
F
K
Y
K
W
T
V
T
V
E
D
G
P
540
541
T
K
S
D
P
R
C
L
T
R
Y
Y
S
S
F
V
N
M
E
R
D
L
A
S
G
L
I
G
P
L
L
I
C
Y
K
E
S
V
D
Q
R
G
N
Q
I
M
S
D
K
R
N
V
I
L
F
S
V
F
D
E
600
601
N
R
S
W
Y
L
T
E
N
I
Q
R
F
L
P
N
P
A
G
V
Q
L
E
D
P
E
F
Q
A
S
N
I
M
H
S
I
N
G
Y
V
F
D
S
L
Q
L
S
V
C
L
H
E
V
A
Y
W
Y
I
L
S
660
661
I
G
A
Q
T
D
F
L
S
V
F
F
S
G
Y
T
F
K
H
K
M
V
Y
E
D
T
L
T
L
F
P
F
S
G
E
T
V
F
M
S
M
E
N
P
G
L
W
I
L
G
C
H
N
S
D
F
R
N
R
G
720
721
M
T
A
L
L
K
V
S
S
C
D
K
N
T
G
D
Y
Y
E
D
S
Y
E
D
I
S
A
Y
L
L
S
K
N
N
A
I
E
P
R
S
F
S
Q
N
S
R
H
P
S
T
R
Q
K
Q
F
N
A
T
T
I
780
781
P
E
N
D
I
E
K
T
D
P
W
F
A
H
R
T
P
M
P
K
I
Q
N
V
S
S
S
D
L
L
M
L
L
R
Q
S
P
T
P
H
G
L
S
L
S
D
L
Q
E
A
K
Y
E
T
F
S
D
D
P
S
840
841
P
G
A
I
D
S
N
N
S
L
S
E
M
T
H
F
R
P
Q
L
H
H
S
G
D
M
V
F
T
P
E
S
G
L
Q
L
R
L
N
E
K
L
G
T
T
A
A
T
E
L
K
K
L
D
F
K
V
S
S
T
900
901
S
N
N
L
I
S
T
I
P
S
D
N
L
A
A
G
T
D
N
T
S
S
L
G
P
P
S
M
P
V
H
Y
D
S
Q
L
D
T
T
L
F
G
K
K
S
S
P
L
T
E
S
G
G
P
L
S
L
S
E
E
960
961
N
N
D
S
K
L
L
E
S
G
L
M
N
S
Q
E
S
S
W
G
K
N
V
S
S
T
E
S
G
R
L
F
K
G
K
R
A
H
G
P
A
L
L
T
K
D
N
A
L
F
K
V
S
I
S
L
L
K
T
N
1020
1021
K
T
S
N
N
S
A
T
N
R
K
T
H
I
D
G
P
S
L
L
I
E
N
S
P
S
V
W
Q
N
I
L
E
S
D
T
E
F
K
K
V
T
P
L
I
H
D
R
M
L
M
D
K
N
A
T
A
L
R
L
1080
1081
N
H
M
S
N
K
T
T
S
S
K
N
M
E
M
V
Q
Q
K
K
E
G
P
I
P
P
D
A
Q
N
P
D
M
S
F
F
K
M
L
F
L
P
E
S
A
R
W
I
Q
R
T
H
G
K
N
S
L
N
S
G
1140
1141
Q
G
P
S
P
K
Q
L
V
S
L
G
P
E
K
S
V
E
G
Q
N
F
L
S
E
K
N
K
V
V
V
G
K
G
E
F
T
K
D
V
G
L
K
E
M
V
F
P
S
S
R
N
L
F
L
T
N
L
D
N
1200
1201
L
H
E
N
N
T
H
N
Q
E
K
K
I
Q
E
E
I
E
K
K
E
T
L
I
Q
E
N
V
V
L
P
Q
I
H
T
V
T
G
T
K
N
F
M
K
N
L
F
L
L
S
T
R
Q
N
V
E
G
S
Y
D
1260
1261
G
A
Y
A
P
V
L
Q
D
F
R
S
L
N
D
S
T
N
R
T
K
K
H
T
A
H
F
S
K
K
G
E
E
E
N
L
E
G
L
G
N
Q
T
K
Q
I
V
E
K
Y
A
C
T
T
R
I
S
P
N
T
1320
1321
S
Q
Q
N
F
V
T
Q
R
S
K
R
A
L
K
Q
F
R
L
P
L
E
E
T
E
L
E
K
R
I
I
V
D
D
T
S
T
Q
W
S
K
N
M
K
H
L
T
P
S
T
L
T
Q
I
D
Y
N
E
K
E
1380
1381
K
G
A
I
T
Q
S
P
L
S
D
C
L
T
R
S
H
S
I
P
Q
A
N
R
S
P
L
P
I
A
K
V
S
S
F
P
S
I
R
P
I
Y
L
T
R
V
L
F
Q
D
N
S
S
H
L
P
A
A
S
Y
1440
1441
R
K
K
D
S
G
V
Q
E
S
S
H
F
L
Q
G
A
K
K
N
N
L
S
L
A
I
L
T
L
E
M
T
G
D
Q
R
E
V
G
S
L
G
T
S
A
T
N
S
V
T
Y
K
K
V
E
N
T
V
L
P
1500
1501
K
P
D
L
P
K
T
S
G
K
V
E
L
L
P
K
V
H
I
Y
Q
K
D
L
F
P
T
E
T
S
N
G
S
P
G
H
L
D
L
V
E
G
S
L
L
Q
G
T
E
G
A
I
K
W
N
E
A
N
R
P
1560
1561
G
K
V
P
F
L
R
V
A
T
E
S
S
A
K
T
P
S
K
L
L
D
P
L
A
W
D
N
H
Y
G
T
Q
I
P
K
E
E
W
K
S
Q
E
K
S
P
E
K
T
A
F
K
K
K
D
T
I
L
S
L
1620
1621
N
A
C
E
S
N
H
A
I
A
A
I
N
E
G
Q
N
K
P
E
I
E
V
T
W
A
K
Q
G
R
T
E
R
L
C
S
Q
N
P
P
V
L
K
R
H
Q
R
E
I
T
R
T
T
L
Q
S
D
Q
E
E
1680
1681
I
D
Y
D
D
T
I
S
V
E
M
K
K
E
D
F
D
I
Y
D
E
D
E
N
Q
S
P
R
S
F
Q
K
K
T
R
H
Y
F
I
A
A
V
E
R
L
W
D
Y
G
M
S
S
S
P
H
V
L
R
N
R
1740
1741
A
Q
S
G
S
V
P
Q
F
K
K
V
V
F
Q
E
F
T
D
G
S
F
T
Q
P
L
Y
R
G
E
L
N
E
H
L
G
L
L
G
P
Y
I
R
A
E
V
E
D
N
I
M
V
T
F
R
N
Q
A
S
R
1800
1801
P
Y
S
F
Y
S
S
L
I
S
Y
E
E
D
Q
R
Q
G
A
E
P
R
K
N
F
V
K
P
N
E
T
K
T
Y
F
W
K
V
Q
H
H
M
A
P
T
K
D
E
F
D
C
K
A
W
A
Y
F
S
D
V
1860
1861
D
L
E
K
D
V
H
S
G
L
I
G
P
L
L
V
C
H
T
N
T
L
N
P
A
H
G
R
Q
V
T
V
Q
E
F
A
L
F
F
T
I
F
D
E
T
K
S
W
Y
F
T
E
N
M
E
R
N
C
R
A
1920
1921
P
C
N
I
Q
M
E
D
P
T
F
K
E
N
Y
R
F
H
A
I
N
G
Y
I
M
D
T
L
P
G
L
V
M
A
Q
D
Q
R
I
R
W
Y
L
L
S
M
G
S
N
E
N
I
H
S
I
H
F
S
G
H
1980
1981
V
F
T
V
R
K
K
E
E
Y
K
M
A
L
Y
N
L
Y
P
G
V
F
E
T
V
E
M
L
P
S
K
A
G
I
W
R
V
E
C
L
I
G
E
H
L
H
A
G
M
S
T
L
F
L
V
Y
S
N
K
C
2040
2041
Q
T
P
L
G
M
A
S
G
H
I
R
D
F
Q
I
T
A
S
G
Q
Y
G
Q
W
A
P
K
L
A
R
L
H
Y
S
G
S
I
N
A
W
S
T
K
E
P
F
S
W
I
K
V
D
L
L
A
P
M
I
I
2100
2101
H
G
I
K
T
Q
G
A
R
Q
K
F
S
S
L
Y
I
S
Q
F
I
I
M
Y
S
L
D
G
K
K
W
Q
T
Y
R
G
N
S
T
G
T
L
M
V
F
F
G
N
V
D
S
S
G
I
K
H
N
I
F
N
2160
2161
P
P
I
I
A
R
Y
I
R
L
H
P
T
H
Y
S
I
R
S
T
L
R
M
E
L
M
G
C
D
L
N
S
C
S
M
P
L
G
M
E
S
K
A
I
S
D
A
Q
I
T
A
S
S
Y
F
T
N
M
F
A
2220
2221
T
W
S
P
S
K
A
R
L
H
L
Q
G
R
S
N
A
W
R
P
Q
V
N
N
P
K
E
W
L
Q
V
D
F
Q
K
T
M
K
V
T
G
V
T
T
Q
G
V
K
S
L
L
T
S
M
Y
V
K
E
F
L
2280
2281
I
S
S
S
Q
D
G
H
Q
W
T
L
F
F
Q
N
G
K
V
K
V
F
Q
G
N
Q
D
S
F
T
P
V
V
N
S
L
D
P
P
L
L
T
R
Y
L
R
I
H
P
Q
S
W
V
H
Q
I
A
L
R
M
2340
2341
E
V
L
G
C
E
A
Q
D
L
Y
2351
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0615
Peptide:
LLFYHI
Length:
6
Classification:
Non-amyloid
Mutation(s):
C329F
Structure(s):
No structures
Protein Information
UniProt ID:
P00451
UniProt Name:
FA8_HUMAN
Protein Name:
Coagulation factor VIII
Position:
327-332
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.0
Tango:
7.11
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
76.8
Area of the profile Above Threshold (AGGRESCAN):
5.15
Best Energy Score (PASTA 2.0):
-4.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0616 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
I
E
L
S
T
C
F
F
L
C
L
L
R
F
C
F
S
A
T
R
R
Y
Y
L
G
A
V
E
L
S
W
D
Y
M
Q
S
D
L
G
E
L
P
V
D
A
R
F
P
P
R
V
P
K
S
F
P
F
N
60
61
T
S
V
V
Y
K
K
T
L
F
V
E
F
T
D
H
L
F
N
I
A
K
P
R
P
P
W
M
G
L
L
G
P
T
I
Q
A
E
V
Y
D
T
V
V
I
T
L
K
N
M
A
S
H
P
V
S
L
H
A
V
120
121
G
V
S
Y
W
K
A
S
E
G
A
E
Y
D
D
Q
T
S
Q
R
E
K
E
D
D
K
V
F
P
G
G
S
H
T
Y
V
W
Q
V
L
K
E
N
G
P
M
A
S
D
P
L
C
L
T
Y
S
Y
L
S
H
180
181
V
D
L
V
K
D
L
N
S
G
L
I
G
A
L
L
V
C
R
E
G
S
L
A
K
E
K
T
Q
T
L
H
K
F
I
L
L
F
A
V
F
D
E
G
K
S
W
H
S
E
T
K
N
S
L
M
Q
D
R
D
240
241
A
A
S
A
R
A
W
P
K
M
H
T
V
N
G
Y
V
N
R
S
L
P
G
L
I
G
C
H
R
K
S
V
Y
W
H
V
I
G
M
G
T
T
P
E
V
H
S
I
F
L
E
G
H
T
F
L
V
R
N
H
300
301
R
Q
A
S
L
E
I
S
P
I
T
F
L
T
A
Q
T
L
L
M
D
L
G
Q
F
L
L
F
C
H
I
S
S
H
Q
H
D
G
M
E
A
Y
V
K
V
D
S
C
P
E
E
P
Q
L
R
M
K
N
N
E
360
361
E
A
E
D
Y
D
D
D
L
T
D
S
E
M
D
V
V
R
F
D
D
D
N
S
P
S
F
I
Q
I
R
S
V
A
K
K
H
P
K
T
W
V
H
Y
I
A
A
E
E
E
D
W
D
Y
A
P
L
V
L
A
420
421
P
D
D
R
S
Y
K
S
Q
Y
L
N
N
G
P
Q
R
I
G
R
K
Y
K
K
V
R
F
M
A
Y
T
D
E
T
F
K
T
R
E
A
I
Q
H
E
S
G
I
L
G
P
L
L
Y
G
E
V
G
D
T
L
480
481
L
I
I
F
K
N
Q
A
S
R
P
Y
N
I
Y
P
H
G
I
T
D
V
R
P
L
Y
S
R
R
L
P
K
G
V
K
H
L
K
D
F
P
I
L
P
G
E
I
F
K
Y
K
W
T
V
T
V
E
D
G
P
540
541
T
K
S
D
P
R
C
L
T
R
Y
Y
S
S
F
V
N
M
E
R
D
L
A
S
G
L
I
G
P
L
L
I
C
Y
K
E
S
V
D
Q
R
G
N
Q
I
M
S
D
K
R
N
V
I
L
F
S
V
F
D
E
600
601
N
R
S
W
Y
L
T
E
N
I
Q
R
F
L
P
N
P
A
G
V
Q
L
E
D
P
E
F
Q
A
S
N
I
M
H
S
I
N
G
Y
V
F
D
S
L
Q
L
S
V
C
L
H
E
V
A
Y
W
Y
I
L
S
660
661
I
G
A
Q
T
D
F
L
S
V
F
F
S
G
Y
T
F
K
H
K
M
V
Y
E
D
T
L
T
L
F
P
F
S
G
E
T
V
F
M
S
M
E
N
P
G
L
W
I
L
G
C
H
N
S
D
F
R
N
R
G
720
721
M
T
A
L
L
K
V
S
S
C
D
K
N
T
G
D
Y
Y
E
D
S
Y
E
D
I
S
A
Y
L
L
S
K
N
N
A
I
E
P
R
S
F
S
Q
N
S
R
H
P
S
T
R
Q
K
Q
F
N
A
T
T
I
780
781
P
E
N
D
I
E
K
T
D
P
W
F
A
H
R
T
P
M
P
K
I
Q
N
V
S
S
S
D
L
L
M
L
L
R
Q
S
P
T
P
H
G
L
S
L
S
D
L
Q
E
A
K
Y
E
T
F
S
D
D
P
S
840
841
P
G
A
I
D
S
N
N
S
L
S
E
M
T
H
F
R
P
Q
L
H
H
S
G
D
M
V
F
T
P
E
S
G
L
Q
L
R
L
N
E
K
L
G
T
T
A
A
T
E
L
K
K
L
D
F
K
V
S
S
T
900
901
S
N
N
L
I
S
T
I
P
S
D
N
L
A
A
G
T
D
N
T
S
S
L
G
P
P
S
M
P
V
H
Y
D
S
Q
L
D
T
T
L
F
G
K
K
S
S
P
L
T
E
S
G
G
P
L
S
L
S
E
E
960
961
N
N
D
S
K
L
L
E
S
G
L
M
N
S
Q
E
S
S
W
G
K
N
V
S
S
T
E
S
G
R
L
F
K
G
K
R
A
H
G
P
A
L
L
T
K
D
N
A
L
F
K
V
S
I
S
L
L
K
T
N
1020
1021
K
T
S
N
N
S
A
T
N
R
K
T
H
I
D
G
P
S
L
L
I
E
N
S
P
S
V
W
Q
N
I
L
E
S
D
T
E
F
K
K
V
T
P
L
I
H
D
R
M
L
M
D
K
N
A
T
A
L
R
L
1080
1081
N
H
M
S
N
K
T
T
S
S
K
N
M
E
M
V
Q
Q
K
K
E
G
P
I
P
P
D
A
Q
N
P
D
M
S
F
F
K
M
L
F
L
P
E
S
A
R
W
I
Q
R
T
H
G
K
N
S
L
N
S
G
1140
1141
Q
G
P
S
P
K
Q
L
V
S
L
G
P
E
K
S
V
E
G
Q
N
F
L
S
E
K
N
K
V
V
V
G
K
G
E
F
T
K
D
V
G
L
K
E
M
V
F
P
S
S
R
N
L
F
L
T
N
L
D
N
1200
1201
L
H
E
N
N
T
H
N
Q
E
K
K
I
Q
E
E
I
E
K
K
E
T
L
I
Q
E
N
V
V
L
P
Q
I
H
T
V
T
G
T
K
N
F
M
K
N
L
F
L
L
S
T
R
Q
N
V
E
G
S
Y
D
1260
1261
G
A
Y
A
P
V
L
Q
D
F
R
S
L
N
D
S
T
N
R
T
K
K
H
T
A
H
F
S
K
K
G
E
E
E
N
L
E
G
L
G
N
Q
T
K
Q
I
V
E
K
Y
A
C
T
T
R
I
S
P
N
T
1320
1321
S
Q
Q
N
F
V
T
Q
R
S
K
R
A
L
K
Q
F
R
L
P
L
E
E
T
E
L
E
K
R
I
I
V
D
D
T
S
T
Q
W
S
K
N
M
K
H
L
T
P
S
T
L
T
Q
I
D
Y
N
E
K
E
1380
1381
K
G
A
I
T
Q
S
P
L
S
D
C
L
T
R
S
H
S
I
P
Q
A
N
R
S
P
L
P
I
A
K
V
S
S
F
P
S
I
R
P
I
Y
L
T
R
V
L
F
Q
D
N
S
S
H
L
P
A
A
S
Y
1440
1441
R
K
K
D
S
G
V
Q
E
S
S
H
F
L
Q
G
A
K
K
N
N
L
S
L
A
I
L
T
L
E
M
T
G
D
Q
R
E
V
G
S
L
G
T
S
A
T
N
S
V
T
Y
K
K
V
E
N
T
V
L
P
1500
1501
K
P
D
L
P
K
T
S
G
K
V
E
L
L
P
K
V
H
I
Y
Q
K
D
L
F
P
T
E
T
S
N
G
S
P
G
H
L
D
L
V
E
G
S
L
L
Q
G
T
E
G
A
I
K
W
N
E
A
N
R
P
1560
1561
G
K
V
P
F
L
R
V
A
T
E
S
S
A
K
T
P
S
K
L
L
D
P
L
A
W
D
N
H
Y
G
T
Q
I
P
K
E
E
W
K
S
Q
E
K
S
P
E
K
T
A
F
K
K
K
D
T
I
L
S
L
1620
1621
N
A
C
E
S
N
H
A
I
A
A
I
N
E
G
Q
N
K
P
E
I
E
V
T
W
A
K
Q
G
R
T
E
R
L
C
S
Q
N
P
P
V
L
K
R
H
Q
R
E
I
T
R
T
T
L
Q
S
D
Q
E
E
1680
1681
I
D
Y
D
D
T
I
S
V
E
M
K
K
E
D
F
D
I
Y
D
E
D
E
N
Q
S
P
R
S
F
Q
K
K
T
R
H
Y
F
I
A
A
V
E
R
L
W
D
Y
G
M
S
S
S
P
H
V
L
R
N
R
1740
1741
A
Q
S
G
S
V
P
Q
F
K
K
V
V
F
Q
E
F
T
D
G
S
F
T
Q
P
L
Y
R
G
E
L
N
E
H
L
G
L
L
G
P
Y
I
R
A
E
V
E
D
N
I
M
V
T
F
R
N
Q
A
S
R
1800
1801
P
Y
S
F
Y
S
S
L
I
S
Y
E
E
D
Q
R
Q
G
A
E
P
R
K
N
F
V
K
P
N
E
T
K
T
Y
F
W
K
V
Q
H
H
M
A
P
T
K
D
E
F
D
C
K
A
W
A
Y
F
S
D
V
1860
1861
D
L
E
K
D
V
H
S
G
L
I
G
P
L
L
V
C
H
T
N
T
L
N
P
A
H
G
R
Q
V
T
V
Q
E
F
A
L
F
F
T
I
F
D
E
T
K
S
W
Y
F
T
E
N
M
E
R
N
C
R
A
1920
1921
P
C
N
I
Q
M
E
D
P
T
F
K
E
N
Y
R
F
H
A
I
N
G
Y
I
M
D
T
L
P
G
L
V
M
A
Q
D
Q
R
I
R
W
Y
L
L
S
M
G
S
N
E
N
I
H
S
I
H
F
S
G
H
1980
1981
V
F
T
V
R
K
K
E
E
Y
K
M
A
L
Y
N
L
Y
P
G
V
F
E
T
V
E
M
L
P
S
K
A
G
I
W
R
V
E
C
L
I
G
E
H
L
H
A
G
M
S
T
L
F
L
V
Y
S
N
K
C
2040
2041
Q
T
P
L
G
M
A
S
G
H
I
R
D
F
Q
I
T
A
S
G
Q
Y
G
Q
W
A
P
K
L
A
R
L
H
Y
S
G
S
I
N
A
W
S
T
K
E
P
F
S
W
I
K
V
D
L
L
A
P
M
I
I
2100
2101
H
G
I
K
T
Q
G
A
R
Q
K
F
S
S
L
Y
I
S
Q
F
I
I
M
Y
S
L
D
G
K
K
W
Q
T
Y
R
G
N
S
T
G
T
L
M
V
F
F
G
N
V
D
S
S
G
I
K
H
N
I
F
N
2160
2161
P
P
I
I
A
R
Y
I
R
L
H
P
T
H
Y
S
I
R
S
T
L
R
M
E
L
M
G
C
D
L
N
S
C
S
M
P
L
G
M
E
S
K
A
I
S
D
A
Q
I
T
A
S
S
Y
F
T
N
M
F
A
2220
2221
T
W
S
P
S
K
A
R
L
H
L
Q
G
R
S
N
A
W
R
P
Q
V
N
N
P
K
E
W
L
Q
V
D
F
Q
K
T
M
K
V
T
G
V
T
T
Q
G
V
K
S
L
L
T
S
M
Y
V
K
E
F
L
2280
2281
I
S
S
S
Q
D
G
H
Q
W
T
L
F
F
Q
N
G
K
V
K
V
F
Q
G
N
Q
D
S
F
T
P
V
V
N
S
L
D
P
P
L
L
T
R
Y
L
R
I
H
P
Q
S
W
V
H
Q
I
A
L
R
M
2340
2341
E
V
L
G
C
E
A
Q
D
L
Y
2351
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0616
Peptide:
LLGPTI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00451
UniProt Name:
FA8_HUMAN
Protein Name:
Coagulation factor VIII
Position:
90-95
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.38
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.9
Area of the profile Above Threshold (AGGRESCAN):
0.55
Best Energy Score (PASTA 2.0):
2.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0617 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
P
P
K
K
F
K
D
L
N
S
F
L
D
D
Q
P
K
D
P
N
L
V
A
S
P
F
G
G
Y
F
K
N
P
A
A
D
A
G
S
N
N
A
S
K
K
S
S
Y
Q
Q
Q
R
N
W
K
Q
G
G
N
60
61
Y
Q
Q
G
G
Y
Q
S
Y
N
S
N
Y
N
N
Y
N
N
Y
N
N
Y
N
N
Y
N
N
Y
N
N
Y
N
K
Y
N
G
Q
G
Y
Q
K
S
T
Y
K
Q
S
A
V
T
P
N
Q
S
G
T
P
T
P
S
120
121
A
S
T
T
S
L
T
S
L
N
E
K
L
S
N
L
E
L
T
P
I
S
Q
F
L
S
K
I
P
E
C
Q
S
I
T
D
C
K
N
Q
I
K
L
I
I
E
E
F
G
K
E
G
N
S
T
G
E
K
I
E
180
181
E
W
K
I
V
D
V
L
S
K
F
I
K
P
K
N
P
S
L
V
R
E
S
A
M
L
I
I
S
N
I
A
Q
F
F
S
G
K
P
P
Q
E
A
Y
L
L
P
F
F
N
V
A
L
D
C
I
S
D
K
E
240
241
N
T
V
K
R
A
A
Q
H
A
I
D
S
L
L
N
C
F
P
M
E
A
L
T
C
F
V
L
P
T
I
L
D
Y
L
S
S
G
A
K
W
Q
A
K
M
A
A
L
S
V
V
D
R
I
R
E
D
S
A
N
300
301
D
L
L
E
L
T
F
K
D
A
V
P
V
L
T
D
V
A
T
D
F
K
P
E
L
A
K
Q
G
Y
K
T
L
L
D
Y
V
S
I
L
D
N
L
D
L
S
P
R
Y
K
L
I
V
D
T
L
Q
D
P
S
360
361
K
V
P
E
S
V
K
S
L
S
S
V
T
F
V
A
E
V
T
E
P
S
L
S
L
L
V
P
I
L
N
R
S
L
N
L
S
S
S
S
Q
E
Q
L
R
Q
T
V
I
V
V
E
N
L
T
R
L
V
N
N
420
421
R
N
E
I
E
S
F
I
P
L
L
L
P
G
I
Q
K
V
V
D
T
A
S
L
P
E
V
R
E
L
A
E
K
A
L
N
V
L
K
E
D
D
E
A
D
K
E
N
K
F
S
G
R
L
T
L
E
E
G
R
480
481
D
F
L
L
D
H
L
K
D
I
K
A
D
D
S
C
F
V
K
P
Y
M
N
D
E
T
V
I
K
Y
M
S
K
I
L
T
V
D
S
N
V
N
D
W
K
R
L
E
D
F
L
T
A
V
F
G
G
S
D
S
540
541
Q
R
E
F
V
K
Q
D
F
I
H
N
L
R
A
L
F
Y
Q
E
K
E
R
A
D
E
D
E
G
I
E
I
V
N
T
D
F
S
L
A
Y
G
S
R
M
L
L
N
K
T
N
L
R
L
L
K
G
H
R
Y
600
601
G
L
C
G
R
N
G
A
G
K
S
T
L
M
R
A
I
A
N
G
Q
L
D
G
F
P
D
K
D
T
L
R
T
C
F
V
E
H
K
L
Q
G
E
E
G
D
L
D
L
V
S
F
I
A
L
D
E
E
L
Q
660
661
S
T
S
R
E
E
I
A
A
A
L
E
S
V
G
F
D
E
E
R
R
A
Q
T
V
G
S
L
S
G
G
W
K
M
K
L
E
L
A
R
A
M
L
Q
K
A
D
I
L
L
L
D
E
P
T
N
H
L
D
V
720
721
S
N
V
K
W
L
E
E
Y
L
L
E
H
T
D
I
T
S
L
I
V
S
H
D
S
G
F
L
D
T
V
C
T
D
I
I
H
Y
E
N
K
K
L
A
Y
Y
K
G
N
L
A
A
F
V
E
Q
K
P
E
A
780
781
K
S
Y
Y
T
L
T
D
S
N
A
Q
M
R
F
P
P
P
G
I
L
T
G
V
K
S
N
T
R
A
V
A
K
M
T
D
V
T
F
S
Y
P
G
A
Q
K
P
S
L
S
H
V
S
C
S
L
S
L
S
S
840
841
R
V
A
C
L
G
P
N
G
A
G
K
S
T
L
I
K
L
L
T
G
E
L
V
P
N
E
G
K
V
E
K
H
P
N
L
R
I
G
Y
I
A
Q
H
A
L
Q
H
V
N
E
H
K
E
K
T
A
N
Q
Y
900
901
L
Q
W
R
Y
Q
F
G
D
D
R
E
V
L
L
K
E
S
R
K
I
S
E
D
E
K
E
M
M
T
K
E
I
D
I
D
D
G
R
G
K
R
A
I
E
A
I
V
G
R
Q
K
L
K
K
S
F
Q
Y
E
960
961
V
K
W
K
Y
W
K
P
K
Y
N
S
W
V
P
K
D
V
L
V
E
H
G
F
E
K
L
V
Q
K
F
D
D
H
E
A
S
R
E
G
L
G
Y
R
E
L
I
P
S
V
I
T
K
H
F
E
D
V
G
L
1020
1021
D
S
E
I
A
N
H
T
P
L
G
S
L
S
G
G
Q
L
V
K
V
V
I
A
G
A
M
W
N
N
P
H
L
L
V
L
D
E
P
T
N
Y
L
D
R
D
S
L
G
A
L
A
V
A
I
R
D
W
S
G
1080
1081
G
V
V
M
I
S
H
N
N
E
F
V
G
A
L
C
P
E
Q
W
I
V
E
N
G
K
M
V
Q
K
G
S
A
Q
V
D
Q
S
K
F
E
D
G
G
N
A
D
A
V
G
L
K
A
S
N
L
A
K
P
S
1140
1141
V
D
D
D
D
S
P
A
N
I
K
V
K
Q
R
K
K
R
L
T
R
N
E
K
K
L
Q
A
E
R
R
R
L
R
Y
I
E
W
L
S
S
P
K
G
T
P
K
P
V
D
T
D
D
E
E
D
1196
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0617
Peptide:
LLNKTN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q08972
UniProt Name:
NEW1_YEAST
Protein Name:
[NU+] prion formation protein 1
Position:
586-591
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.22
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-45.7
Area of the profile Above Threshold (AGGRESCAN):
0.09
Best Energy Score (PASTA 2.0):
-0.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0618 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0618
Peptide:
LLTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39L
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.0
Tango:
30.09
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
74.2
Area of the profile Above Threshold (AGGRESCAN):
4.84
Best Energy Score (PASTA 2.0):
-6.04
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0619 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
I
E
L
S
T
C
F
F
L
C
L
L
R
F
C
F
S
A
T
R
R
Y
Y
L
G
A
V
E
L
S
W
D
Y
M
Q
S
D
L
G
E
L
P
V
D
A
R
F
P
P
R
V
P
K
S
F
P
F
N
60
61
T
S
V
V
Y
K
K
T
L
F
V
E
F
T
D
H
L
F
N
I
A
K
P
R
P
P
W
M
G
L
L
G
P
T
I
Q
A
E
V
Y
D
T
V
V
I
T
L
K
N
M
A
S
H
P
V
S
L
H
A
V
120
121
G
V
S
Y
W
K
A
S
E
G
A
E
Y
D
D
Q
T
S
Q
R
E
K
E
D
D
K
V
F
P
G
G
S
H
T
Y
V
W
Q
V
L
K
E
N
G
P
M
A
S
D
P
L
C
L
T
Y
S
Y
L
S
H
180
181
V
D
L
V
K
D
L
N
S
G
L
I
G
A
L
L
V
C
R
E
G
S
L
A
K
E
K
T
Q
T
L
H
K
F
I
L
L
F
A
V
F
D
E
G
K
S
W
H
S
E
T
K
N
S
L
M
Q
D
R
D
240
241
A
A
S
A
R
A
W
P
K
M
H
T
V
N
G
Y
V
N
R
S
L
P
G
L
I
G
C
H
R
K
S
V
Y
W
H
V
I
G
M
G
T
T
P
E
V
H
S
I
F
L
E
G
H
T
F
L
V
R
N
H
300
301
R
Q
A
S
L
E
I
S
P
I
T
F
L
T
A
Q
T
L
L
M
D
L
G
Q
F
L
L
F
C
H
I
S
S
H
Q
H
D
G
M
E
A
Y
V
K
V
D
S
C
P
E
E
P
Q
L
R
M
K
N
N
E
360
361
E
A
E
D
Y
D
D
D
L
T
D
S
E
M
D
V
V
R
F
D
D
D
N
S
P
S
F
I
Q
I
R
S
V
A
K
K
H
P
K
T
W
V
H
Y
I
A
A
E
E
E
D
W
D
Y
A
P
L
V
L
A
420
421
P
D
D
R
S
Y
K
S
Q
Y
L
N
N
G
P
Q
R
I
G
R
K
Y
K
K
V
R
F
M
A
Y
T
D
E
T
F
K
T
R
E
A
I
Q
H
E
S
G
I
L
G
P
L
L
Y
G
E
V
G
D
T
L
480
481
L
I
I
F
K
N
Q
A
S
R
P
Y
N
I
Y
P
H
G
I
T
D
V
R
P
L
Y
S
R
R
L
P
K
G
V
K
H
L
K
D
F
P
I
L
P
G
E
I
F
K
Y
K
W
T
V
T
V
E
D
G
P
540
541
T
K
S
D
P
R
C
L
T
R
Y
Y
S
S
F
V
N
M
E
R
D
L
A
S
G
L
I
G
P
L
L
I
C
Y
K
E
S
V
D
Q
R
G
N
Q
I
M
S
D
K
R
N
V
I
L
F
S
V
F
D
E
600
601
N
R
S
W
Y
L
T
E
N
I
Q
R
F
L
P
N
P
A
G
V
Q
L
E
D
P
E
F
Q
A
S
N
I
M
H
S
I
N
G
Y
V
F
D
S
L
Q
L
S
V
C
L
H
E
V
A
Y
W
Y
I
L
S
660
661
I
G
A
Q
T
D
F
L
S
V
F
F
S
G
Y
T
F
K
H
K
M
V
Y
E
D
T
L
T
L
F
P
F
S
G
E
T
V
F
M
S
M
E
N
P
G
L
W
I
L
G
C
H
N
S
D
F
R
N
R
G
720
721
M
T
A
L
L
K
V
S
S
C
D
K
N
T
G
D
Y
Y
E
D
S
Y
E
D
I
S
A
Y
L
L
S
K
N
N
A
I
E
P
R
S
F
S
Q
N
S
R
H
P
S
T
R
Q
K
Q
F
N
A
T
T
I
780
781
P
E
N
D
I
E
K
T
D
P
W
F
A
H
R
T
P
M
P
K
I
Q
N
V
S
S
S
D
L
L
M
L
L
R
Q
S
P
T
P
H
G
L
S
L
S
D
L
Q
E
A
K
Y
E
T
F
S
D
D
P
S
840
841
P
G
A
I
D
S
N
N
S
L
S
E
M
T
H
F
R
P
Q
L
H
H
S
G
D
M
V
F
T
P
E
S
G
L
Q
L
R
L
N
E
K
L
G
T
T
A
A
T
E
L
K
K
L
D
F
K
V
S
S
T
900
901
S
N
N
L
I
S
T
I
P
S
D
N
L
A
A
G
T
D
N
T
S
S
L
G
P
P
S
M
P
V
H
Y
D
S
Q
L
D
T
T
L
F
G
K
K
S
S
P
L
T
E
S
G
G
P
L
S
L
S
E
E
960
961
N
N
D
S
K
L
L
E
S
G
L
M
N
S
Q
E
S
S
W
G
K
N
V
S
S
T
E
S
G
R
L
F
K
G
K
R
A
H
G
P
A
L
L
T
K
D
N
A
L
F
K
V
S
I
S
L
L
K
T
N
1020
1021
K
T
S
N
N
S
A
T
N
R
K
T
H
I
D
G
P
S
L
L
I
E
N
S
P
S
V
W
Q
N
I
L
E
S
D
T
E
F
K
K
V
T
P
L
I
H
D
R
M
L
M
D
K
N
A
T
A
L
R
L
1080
1081
N
H
M
S
N
K
T
T
S
S
K
N
M
E
M
V
Q
Q
K
K
E
G
P
I
P
P
D
A
Q
N
P
D
M
S
F
F
K
M
L
F
L
P
E
S
A
R
W
I
Q
R
T
H
G
K
N
S
L
N
S
G
1140
1141
Q
G
P
S
P
K
Q
L
V
S
L
G
P
E
K
S
V
E
G
Q
N
F
L
S
E
K
N
K
V
V
V
G
K
G
E
F
T
K
D
V
G
L
K
E
M
V
F
P
S
S
R
N
L
F
L
T
N
L
D
N
1200
1201
L
H
E
N
N
T
H
N
Q
E
K
K
I
Q
E
E
I
E
K
K
E
T
L
I
Q
E
N
V
V
L
P
Q
I
H
T
V
T
G
T
K
N
F
M
K
N
L
F
L
L
S
T
R
Q
N
V
E
G
S
Y
D
1260
1261
G
A
Y
A
P
V
L
Q
D
F
R
S
L
N
D
S
T
N
R
T
K
K
H
T
A
H
F
S
K
K
G
E
E
E
N
L
E
G
L
G
N
Q
T
K
Q
I
V
E
K
Y
A
C
T
T
R
I
S
P
N
T
1320
1321
S
Q
Q
N
F
V
T
Q
R
S
K
R
A
L
K
Q
F
R
L
P
L
E
E
T
E
L
E
K
R
I
I
V
D
D
T
S
T
Q
W
S
K
N
M
K
H
L
T
P
S
T
L
T
Q
I
D
Y
N
E
K
E
1380
1381
K
G
A
I
T
Q
S
P
L
S
D
C
L
T
R
S
H
S
I
P
Q
A
N
R
S
P
L
P
I
A
K
V
S
S
F
P
S
I
R
P
I
Y
L
T
R
V
L
F
Q
D
N
S
S
H
L
P
A
A
S
Y
1440
1441
R
K
K
D
S
G
V
Q
E
S
S
H
F
L
Q
G
A
K
K
N
N
L
S
L
A
I
L
T
L
E
M
T
G
D
Q
R
E
V
G
S
L
G
T
S
A
T
N
S
V
T
Y
K
K
V
E
N
T
V
L
P
1500
1501
K
P
D
L
P
K
T
S
G
K
V
E
L
L
P
K
V
H
I
Y
Q
K
D
L
F
P
T
E
T
S
N
G
S
P
G
H
L
D
L
V
E
G
S
L
L
Q
G
T
E
G
A
I
K
W
N
E
A
N
R
P
1560
1561
G
K
V
P
F
L
R
V
A
T
E
S
S
A
K
T
P
S
K
L
L
D
P
L
A
W
D
N
H
Y
G
T
Q
I
P
K
E
E
W
K
S
Q
E
K
S
P
E
K
T
A
F
K
K
K
D
T
I
L
S
L
1620
1621
N
A
C
E
S
N
H
A
I
A
A
I
N
E
G
Q
N
K
P
E
I
E
V
T
W
A
K
Q
G
R
T
E
R
L
C
S
Q
N
P
P
V
L
K
R
H
Q
R
E
I
T
R
T
T
L
Q
S
D
Q
E
E
1680
1681
I
D
Y
D
D
T
I
S
V
E
M
K
K
E
D
F
D
I
Y
D
E
D
E
N
Q
S
P
R
S
F
Q
K
K
T
R
H
Y
F
I
A
A
V
E
R
L
W
D
Y
G
M
S
S
S
P
H
V
L
R
N
R
1740
1741
A
Q
S
G
S
V
P
Q
F
K
K
V
V
F
Q
E
F
T
D
G
S
F
T
Q
P
L
Y
R
G
E
L
N
E
H
L
G
L
L
G
P
Y
I
R
A
E
V
E
D
N
I
M
V
T
F
R
N
Q
A
S
R
1800
1801
P
Y
S
F
Y
S
S
L
I
S
Y
E
E
D
Q
R
Q
G
A
E
P
R
K
N
F
V
K
P
N
E
T
K
T
Y
F
W
K
V
Q
H
H
M
A
P
T
K
D
E
F
D
C
K
A
W
A
Y
F
S
D
V
1860
1861
D
L
E
K
D
V
H
S
G
L
I
G
P
L
L
V
C
H
T
N
T
L
N
P
A
H
G
R
Q
V
T
V
Q
E
F
A
L
F
F
T
I
F
D
E
T
K
S
W
Y
F
T
E
N
M
E
R
N
C
R
A
1920
1921
P
C
N
I
Q
M
E
D
P
T
F
K
E
N
Y
R
F
H
A
I
N
G
Y
I
M
D
T
L
P
G
L
V
M
A
Q
D
Q
R
I
R
W
Y
L
L
S
M
G
S
N
E
N
I
H
S
I
H
F
S
G
H
1980
1981
V
F
T
V
R
K
K
E
E
Y
K
M
A
L
Y
N
L
Y
P
G
V
F
E
T
V
E
M
L
P
S
K
A
G
I
W
R
V
E
C
L
I
G
E
H
L
H
A
G
M
S
T
L
F
L
V
Y
S
N
K
C
2040
2041
Q
T
P
L
G
M
A
S
G
H
I
R
D
F
Q
I
T
A
S
G
Q
Y
G
Q
W
A
P
K
L
A
R
L
H
Y
S
G
S
I
N
A
W
S
T
K
E
P
F
S
W
I
K
V
D
L
L
A
P
M
I
I
2100
2101
H
G
I
K
T
Q
G
A
R
Q
K
F
S
S
L
Y
I
S
Q
F
I
I
M
Y
S
L
D
G
K
K
W
Q
T
Y
R
G
N
S
T
G
T
L
M
V
F
F
G
N
V
D
S
S
G
I
K
H
N
I
F
N
2160
2161
P
P
I
I
A
R
Y
I
R
L
H
P
T
H
Y
S
I
R
S
T
L
R
M
E
L
M
G
C
D
L
N
S
C
S
M
P
L
G
M
E
S
K
A
I
S
D
A
Q
I
T
A
S
S
Y
F
T
N
M
F
A
2220
2221
T
W
S
P
S
K
A
R
L
H
L
Q
G
R
S
N
A
W
R
P
Q
V
N
N
P
K
E
W
L
Q
V
D
F
Q
K
T
M
K
V
T
G
V
T
T
Q
G
V
K
S
L
L
T
S
M
Y
V
K
E
F
L
2280
2281
I
S
S
S
Q
D
G
H
Q
W
T
L
F
F
Q
N
G
K
V
K
V
F
Q
G
N
Q
D
S
F
T
P
V
V
N
S
L
D
P
P
L
L
T
R
Y
L
R
I
H
P
Q
S
W
V
H
Q
I
A
L
R
M
2340
2341
E
V
L
G
C
E
A
Q
D
L
Y
2351
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0619
Peptide:
LLVPTI
Length:
6
Classification:
Non-amyloid
Mutation(s):
G92V
Structure(s):
No structures
Protein Information
UniProt ID:
P00451
UniProt Name:
FA8_HUMAN
Protein Name:
Coagulation factor VIII
Position:
90-95
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
-0.06
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
55.4
Area of the profile Above Threshold (AGGRESCAN):
2.82
Best Energy Score (PASTA 2.0):
-1.31
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0620 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0620
Peptide:
LLYYTE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
84-89
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
44.3
Area of the profile Above Threshold (AGGRESCAN):
3.23
Best Energy Score (PASTA 2.0):
-2.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0621 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
D
D
P
E
N
S
K
L
Y
D
L
L
N
S
H
L
D
V
H
G
R
S
N
E
E
P
R
Q
T
G
D
S
R
S
Q
S
S
G
N
T
G
E
N
E
E
D
I
A
F
A
S
G
L
N
G
G
T
F
60
61
D
S
M
L
E
A
L
P
D
D
L
Y
F
T
D
F
V
S
P
F
T
A
A
A
T
T
S
V
T
T
K
T
V
K
D
T
T
P
A
T
N
H
M
D
D
D
I
A
M
F
D
S
L
A
T
T
Q
P
I
D
120
121
I
A
A
S
N
Q
Q
N
G
E
I
A
Q
L
W
D
F
N
V
D
Q
F
N
M
T
P
S
N
S
S
G
S
A
T
I
S
A
P
N
S
F
T
S
D
I
P
Q
Y
N
H
G
S
L
G
N
S
V
S
K
S
180
181
S
L
F
P
Y
N
S
S
T
S
N
S
N
I
N
Q
P
S
I
N
N
N
S
N
T
N
A
Q
S
H
H
S
F
N
I
Y
K
L
Q
N
N
N
S
S
S
S
A
M
N
I
T
N
N
N
N
S
N
N
S
N
240
241
I
Q
H
P
F
L
K
K
S
D
S
I
G
L
S
S
S
N
T
T
N
S
V
R
K
N
S
L
I
K
P
M
S
S
T
S
L
A
N
F
K
R
A
A
S
V
S
S
S
I
S
N
M
E
P
S
G
Q
N
K
300
301
K
P
L
I
Q
C
F
N
C
K
T
F
K
T
P
L
W
R
R
S
P
E
G
N
T
L
C
N
A
C
G
L
F
Q
K
L
H
G
T
M
R
P
L
S
L
K
S
D
V
I
K
K
R
I
S
K
K
R
A
K
360
361
Q
T
D
P
N
I
A
Q
N
T
P
S
A
P
A
T
A
S
T
S
V
T
T
T
N
A
K
P
I
R
S
R
K
K
S
L
Q
Q
N
S
L
S
R
V
I
P
E
E
I
I
R
D
N
I
G
N
T
N
N
I
420
421
L
N
V
N
R
G
G
Y
N
F
N
S
V
P
S
P
V
L
M
N
S
Q
S
Y
N
S
S
N
A
N
F
N
G
A
S
N
A
N
L
N
S
N
N
L
M
R
H
N
S
N
T
V
T
P
N
F
R
R
S
S
480
481
R
R
S
S
T
S
S
N
T
S
S
S
S
K
S
S
S
R
S
V
V
P
I
L
P
K
P
S
P
N
S
A
N
S
Q
Q
F
N
M
N
M
N
L
M
N
T
T
N
N
V
S
A
G
N
S
V
A
S
S
P
540
541
R
I
I
S
S
A
N
F
N
S
N
S
P
L
Q
Q
N
L
L
S
N
S
F
Q
R
Q
G
M
N
I
P
R
R
K
M
S
R
N
A
S
Y
S
S
S
F
M
A
A
S
L
Q
Q
L
H
E
Q
Q
Q
V
D
600
601
V
N
S
N
T
N
T
N
S
N
R
Q
N
W
N
S
S
N
S
V
S
T
N
S
R
S
S
N
F
V
S
Q
K
P
N
F
D
I
F
N
T
P
V
D
S
P
S
V
S
R
P
S
S
R
K
S
H
T
S
L
660
661
L
S
Q
Q
L
Q
N
S
E
S
N
S
F
I
S
N
H
K
F
N
N
R
L
S
S
D
S
T
S
P
I
K
Y
E
A
D
V
S
A
G
G
K
I
S
E
D
N
S
T
K
G
S
S
K
E
S
S
A
I
A
720
721
D
E
L
D
W
L
K
F
G
I
730
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0621
Peptide:
LMNTTN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P18494
UniProt Name:
GLN3_YEAST
Protein Name:
Nitrogen regulatory protein GLN3
Position:
523-528
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.5
Area of the profile Above Threshold (AGGRESCAN):
0.15
Best Energy Score (PASTA 2.0):
-1.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0622 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0622
Peptide:
LMSLFG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
47.6
Area of the profile Above Threshold (AGGRESCAN):
3.16
Best Energy Score (PASTA 2.0):
-1.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0623 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0623
Peptide:
LMTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39M
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.74
Tango:
6.67
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
68.0
Area of the profile Above Threshold (AGGRESCAN):
4.42
Best Energy Score (PASTA 2.0):
-5.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0624 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0624
Peptide:
LNDFQK
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
126-131
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-49.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0625 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0625
Peptide:
LNIYQY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
45-50
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.82
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.2
Area of the profile Above Threshold (AGGRESCAN):
2.26
Best Energy Score (PASTA 2.0):
-3.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0626 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
I
T
E
G
F
P
P
N
L
N
A
L
K
G
S
S
L
L
E
K
R
V
D
S
L
R
Q
L
N
T
T
T
V
N
Q
L
L
G
L
P
G
M
T
S
T
F
T
A
P
Q
L
L
Q
L
R
I
I
A
I
60
61
T
A
S
A
V
S
L
I
A
G
C
L
G
M
F
F
L
S
K
M
D
K
R
R
K
V
F
R
H
D
L
I
A
F
L
I
I
C
D
F
L
K
A
F
I
L
M
I
Y
P
M
I
I
L
I
N
N
S
V
Y
120
121
A
T
P
A
F
F
N
T
L
G
W
F
T
A
F
A
I
E
G
A
D
M
A
I
M
I
F
A
I
H
F
A
I
L
I
F
K
P
N
W
K
W
R
N
K
R
S
G
N
M
E
G
G
L
Y
K
K
R
S
Y
180
181
I
W
P
I
T
A
L
V
P
A
I
L
A
S
L
A
F
I
N
Y
N
K
L
N
D
D
S
D
T
T
I
I
L
D
N
N
N
Y
N
F
P
D
S
P
R
Q
G
G
Y
K
P
W
S
A
W
C
Y
L
P
P
240
241
K
P
Y
W
Y
K
I
V
L
S
W
G
P
R
Y
F
I
I
I
F
I
F
A
V
Y
L
S
I
Y
I
F
I
T
S
E
S
K
R
I
K
A
Q
I
G
D
F
N
H
N
V
L
E
E
E
K
E
K
K
K
L
300
301
F
G
L
G
H
W
G
K
A
K
W
Y
F
R
S
Y
F
K
L
P
L
L
H
L
L
R
N
L
K
N
F
F
T
I
S
F
I
D
P
N
E
E
T
D
D
S
G
S
S
N
G
T
F
N
F
G
E
S
S
N
360
361
E
I
P
T
L
F
R
K
T
N
T
G
S
D
E
N
V
S
A
S
G
G
V
R
L
L
D
Y
N
S
A
K
P
L
D
M
S
K
Y
A
M
S
E
Q
P
D
L
E
R
N
N
P
F
D
C
E
N
D
I
T
420
421
L
N
P
S
E
L
V
S
K
Q
K
E
H
K
V
T
F
S
V
E
N
E
G
L
D
T
R
K
S
S
M
L
G
H
Q
T
F
S
C
Q
N
S
L
E
S
P
L
A
M
Y
D
N
K
N
D
N
S
D
I
T
480
481
S
N
I
K
E
K
G
G
I
I
N
N
N
S
N
N
D
D
D
D
N
N
N
N
N
D
N
D
N
D
N
N
N
S
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
540
541
N
N
N
N
S
N
N
I
K
N
N
V
D
N
N
N
T
N
P
A
D
N
I
P
T
L
S
N
E
A
F
T
P
S
Q
Q
F
S
Q
E
R
V
N
N
N
A
D
R
C
E
N
S
S
F
T
N
V
Q
Q
H
600
601
F
Q
A
Q
T
Y
K
Q
M
K
K
R
R
A
Q
I
Q
K
N
L
R
A
I
F
I
Y
P
L
S
Y
I
G
I
W
L
F
P
I
I
A
D
A
L
Q
Y
N
H
E
I
K
H
G
P
T
M
W
V
T
Y
I
660
661
D
T
C
V
R
P
L
S
C
L
V
D
V
I
V
Y
L
F
K
E
K
P
W
N
Y
S
W
A
K
T
E
S
K
Y
L
I
E
K
Y
I
L
K
G
E
L
G
E
K
E
I
L
K
F
C
H
S
N
W
G
K
720
721
R
G
W
Y
Y
R
G
K
W
K
K
R
K
C
W
K
Y
S
T
N
P
L
K
R
I
L
W
F
V
E
R
F
F
K
Q
L
F
E
L
K
L
H
F
S
F
Y
D
N
C
D
D
F
E
Y
W
E
N
Y
Y
S
780
781
A
K
D
S
N
D
N
K
R
T
E
S
D
E
T
K
T
N
S
S
D
R
S
L
P
S
N
S
L
E
L
Q
A
M
L
N
N
I
T
A
E
E
V
E
V
P
L
F
W
R
I
I
H
H
I
P
M
L
G
G
840
841
I
D
L
D
E
L
N
R
L
L
K
I
R
Y
N
N
D
H
F
S
L
P
G
L
K
F
A
L
N
Q
N
K
S
H
D
K
H
Q
D
V
S
T
N
S
M
V
K
S
S
F
F
S
S
N
I
V
T
N
D
D
900
901
E
N
S
I
E
E
D
K
N
L
R
Y
S
D
A
S
A
S
E
N
Y
L
V
K
P
T
I
P
G
T
T
P
D
P
I
I
E
A
Q
N
D
N
D
S
S
D
S
S
G
I
D
L
I
A
F
L
R
N
G
P
960
961
L
961
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0626
Peptide:
LNNITA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12361
UniProt Name:
GPR1_YEAST
Protein Name:
G protein-coupled receptor GPR1
Position:
815-820
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.09
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.7
Area of the profile Above Threshold (AGGRESCAN):
0.11
Best Energy Score (PASTA 2.0):
-2.77
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0627 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0627
Peptide:
LNTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39N
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.74
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.5
Area of the profile Above Threshold (AGGRESCAN):
2.43
Best Energy Score (PASTA 2.0):
-5.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0628 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0628
Peptide:
LPKVED
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
212-217
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-32.6
Area of the profile Above Threshold (AGGRESCAN):
0.14
Best Energy Score (PASTA 2.0):
0.42
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0629 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0629
Peptide:
LPTVYV
Length:
6
Classification:
amyloid
Mutation(s):
A39P
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
-0.3
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
51.4
Area of the profile Above Threshold (AGGRESCAN):
3.11
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0630 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0630
Peptide:
LQGYQA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
110-115
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.22
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-25.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.68
Aggregate Orientation (PASTA 2.0):
Antiparallel
