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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 751 to 780 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0751
NNNISN
6
Non-amyloid
RNA-binding protein MRN1
Q08925
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0752
NNNISV
6
Non-amyloid
Asparagine-rich protein (Protein ARP)
P32770
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0753
NNNKNN
6
Non-amyloid
Transcription factor PDR1 (Pleiotropic drug resistance protein 1)
P12383
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0754
NNNLQG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0755
NNNNNE
6
Non-amyloid
Serine/threonine-protein kinase KSP1
P38691
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0756
NNNNSN
6
Non-amyloid
SWI/SNF chromatin-remodeling complex subunit SWI1
P09547
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0757
NNNNTN
6
Non-amyloid
SWI/SNF chromatin-remodeling complex subunit SWI1
P09547
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0758
NNNRGG
6
Non-amyloid
polyadenylated RNA-binding protein PUB1
P32588
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0759
NNNSSS
6
Non-amyloid
Transcriptional regulator URE2
P23202
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0760
NNNWSL
6
Amyloid
Asparagine-rich protein (Protein ARP)
P32770
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0761
NNQNTF
6
Amyloid
Major prion protein (PrP) (CD antigen CD230)
P67986
No
Nat Struct Mol Biol. 2009 Sep;16(9):973-8.
19684598
CPAD, Waltz-DB 2.0, AmyLoad
P-0762
NNQQNY
6
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
P-0763
NNRYQG
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0764
NNSGPN
6
Amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0765
NNSYSG
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0766
NNTIFV
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0767
NPAMMA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0768
NPDAGY
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0769
NPQGGR
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0770
NPQGGY
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0771
NQFIIS
6
Amyloid
Transportin-1 (Importin beta-2)
Q92973
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0772
NQFNLM
6
Amyloid
Polypeptide N-acetylgalactosaminyltransferase 1
Q10472
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0773
NQGNNQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0774
NQGYNT
6
Non-amyloid
Serine/threonine-protein kinase KSP1
P38691
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0775
NQIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623N
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0776
NQNMNN
6
Non-amyloid
U6 snRNA-associated Sm-like protein LSm4
P40070
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0777
NQNNFV
6
Amyloid
Major prion protein (PrP)
P04156
No
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
14691246
Waltz-DB 2.0, AmyLoad
P-0778
NQQNQY
6
Amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0779
NQQNYQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0780
NQQQGN
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0751 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
V
S
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
S
N
N
N
N
N
N
N
M
F
P
P
F
P
S
S
D
D
F
A
M
Y
Q
Q
S
S
S
S
G
P
Y
Q
E
T
Y
A
S
G
P
Q
60
61
N
F
G
D
A
V
Y
P
M
N
G
N
F
T
L
L
P
S
D
F
T
R
E
P
N
D
S
F
F
Y
E
N
D
G
I
F
D
Y
Q
R
I
Q
Q
Q
P
T
Q
F
Q
T
K
Q
R
N
D
S
Q
Q
Q
R
120
121
F
S
Q
E
Q
N
F
E
I
D
N
E
V
V
H
N
N
N
R
Y
Y
E
Y
E
R
S
S
N
E
V
S
P
F
D
D
E
N
P
N
V
L
S
D
G
M
S
P
T
I
M
A
T
A
T
A
V
T
N
A
N
180
181
A
P
L
P
V
N
A
Q
A
N
N
P
L
N
F
T
S
A
P
S
R
T
V
Y
L
G
N
V
P
P
N
L
S
V
K
E
L
L
D
H
V
R
S
G
V
V
E
D
V
K
I
I
P
E
K
M
C
A
F
V
240
241
S
F
I
D
E
S
A
A
L
L
F
H
S
D
A
I
L
K
R
L
N
I
G
D
R
D
I
K
I
G
W
G
K
P
T
R
I
D
P
I
V
A
A
R
I
S
T
D
G
A
T
R
N
V
Y
I
G
R
M
T
300
301
I
E
G
E
E
S
H
L
S
E
E
Q
L
R
V
D
L
E
E
Y
G
E
I
D
C
I
K
I
I
K
E
K
G
I
A
F
I
H
F
A
S
I
L
N
A
I
K
V
V
T
N
L
P
I
R
N
P
Y
Y
Q
360
361
N
K
R
I
F
Y
G
K
D
R
C
A
F
I
T
K
T
Q
Q
H
N
A
A
Q
F
L
G
V
Q
P
G
M
E
H
M
I
E
F
S
D
R
E
F
I
S
N
A
L
L
Q
Q
S
A
A
A
A
A
I
A
T
420
421
S
A
G
G
P
N
N
L
G
N
R
T
V
Y
L
G
S
L
P
K
D
V
K
I
E
E
I
C
N
A
V
R
G
G
L
L
Q
S
I
K
L
L
N
D
R
Y
V
C
F
V
T
F
I
D
P
T
A
A
A
Q
480
481
F
Y
A
M
S
S
L
Y
G
F
T
V
Q
K
K
R
C
K
V
G
W
G
K
H
S
G
P
L
P
N
A
L
A
L
A
V
S
N
G
A
S
R
N
V
Y
V
G
N
I
D
F
V
G
D
S
L
R
D
E
R
540
541
V
F
T
E
S
N
L
R
H
I
F
Q
Q
Y
G
E
V
E
Q
I
N
F
L
P
E
K
N
C
C
F
I
N
Y
T
N
I
S
N
A
I
L
A
L
D
K
I
K
S
N
P
Y
F
K
D
L
K
I
N
F
G
600
601
K
D
R
C
G
N
V
P
H
Q
S
R
612
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0751
Peptide:
NNNISN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q08925
UniProt Name:
MRN1_YEAST
Protein Name:
RNA-binding protein MRN1
Position:
17-22
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-55.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0752 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
H
Y
V
V
L
E
L
Q
V
A
H
L
P
D
T
P
K
D
Q
C
R
I
A
N
I
A
F
Q
I
V
N
A
E
T
L
V
C
H
Y
G
T
N
S
L
P
S
I
E
V
N
G
T
T
K
S
L
E
S
A
60
61
M
V
Q
L
D
K
D
I
H
D
V
I
G
N
D
D
F
V
L
V
S
L
Y
S
T
W
H
I
R
V
T
L
P
R
Q
A
R
D
D
G
F
I
L
T
S
Y
L
Q
H
P
K
V
F
D
L
W
K
E
F
D
120
121
R
W
C
V
N
H
P
E
I
L
G
Q
K
K
A
I
S
N
N
N
C
N
T
K
S
I
S
I
N
A
A
K
N
T
K
D
L
D
E
I
V
R
I
L
E
V
S
I
P
T
E
E
A
G
S
V
P
E
I
Y
180
181
S
L
L
K
R
T
T
D
I
L
I
Q
L
H
K
K
C
T
S
P
E
D
M
E
S
V
L
T
K
P
Y
D
S
H
T
D
I
R
A
F
L
Q
E
K
S
K
I
L
Y
M
N
N
L
P
P
D
T
T
Q
S
240
241
E
L
E
S
W
F
T
Q
Y
G
V
R
P
V
G
F
W
T
V
K
N
I
V
E
D
T
S
N
V
N
N
N
W
S
L
N
N
S
P
Y
V
E
D
Q
D
S
I
S
G
F
V
V
F
Q
T
H
E
E
A
T
300
301
E
V
L
A
L
N
G
R
S
I
L
S
N
L
A
N
T
K
Q
P
R
V
V
E
H
V
L
E
L
Q
P
S
S
T
G
V
L
D
K
A
Q
E
I
L
S
P
F
P
Q
S
K
N
K
P
R
P
G
D
W
N
360
361
C
P
S
C
G
F
S
N
F
Q
R
R
T
A
C
F
R
C
S
F
P
A
P
S
N
S
Q
I
H
T
A
N
S
N
N
N
V
N
S
S
R
N
N
L
N
N
R
V
N
S
G
S
S
S
N
I
S
N
T
A
420
421
A
N
H
P
Y
G
A
P
E
F
N
M
I
A
N
N
T
P
A
A
L
T
Y
N
R
A
H
F
P
A
I
T
P
L
S
R
Q
N
S
L
N
M
A
P
S
N
S
G
S
P
I
I
I
A
D
H
F
S
G
N
480
481
N
N
I
A
P
N
Y
R
Y
N
N
N
I
N
N
N
N
N
N
I
N
N
M
T
N
N
R
Y
N
I
N
N
N
I
N
G
N
G
N
G
N
G
N
N
S
N
N
N
N
N
H
N
N
N
H
N
N
N
H
H
540
541
N
G
S
I
N
S
N
S
N
T
N
N
N
N
N
N
N
N
G
N
N
S
N
N
C
N
S
N
I
G
M
G
G
C
G
S
N
M
P
F
R
A
G
D
W
K
C
S
T
C
T
Y
H
N
F
A
K
N
V
V
600
601
C
L
R
C
G
G
P
K
S
I
S
G
D
A
S
E
T
N
H
Y
I
D
S
S
T
F
G
P
A
S
R
T
P
S
N
N
N
I
S
V
N
T
N
G
G
S
N
A
G
R
T
D
G
N
D
N
K
G
R
D
660
661
I
S
L
M
E
F
M
S
P
P
L
S
M
A
T
K
S
M
K
E
G
D
G
N
G
S
S
F
N
E
F
K
S
D
K
A
N
V
N
F
S
N
V
G
D
N
S
A
F
G
N
G
F
N
S
S
I
R
W
719
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0752
Peptide:
NNNISV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32770
UniProt Name:
NRP1_YEAST
Protein Name:
Asparagine-rich protein (Protein ARP)
Position:
635-640
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.0
Area of the profile Above Threshold (AGGRESCAN):
0.46
Best Energy Score (PASTA 2.0):
-3.29
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0753 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
G
L
T
P
K
N
G
V
H
I
E
T
G
P
D
T
E
S
S
A
D
S
S
N
F
S
T
G
F
S
G
K
I
R
K
P
R
S
K
V
S
K
A
C
D
N
C
R
K
R
K
I
K
C
N
G
K
F
60
61
P
C
A
S
C
E
I
Y
S
C
E
C
T
F
S
T
R
Q
G
G
A
R
I
K
N
L
H
K
T
S
L
E
G
T
T
V
Q
V
K
E
E
T
D
S
S
S
T
S
F
S
N
P
Q
R
C
T
D
G
P
C
120
121
A
V
E
Q
P
T
K
F
F
E
N
F
K
L
G
G
R
S
S
G
D
N
S
G
S
D
G
K
N
D
D
D
V
N
R
N
G
F
Y
E
D
D
S
E
S
Q
A
T
L
T
S
L
Q
T
T
L
K
N
L
K
180
181
E
M
A
H
L
G
T
H
V
T
S
A
I
E
S
I
E
L
Q
I
S
D
L
L
K
R
W
E
P
K
V
R
T
K
E
L
A
T
T
K
F
Y
P
N
K
S
I
E
T
Q
L
M
K
N
K
Y
C
D
V
V
240
241
H
L
T
R
Y
A
A
W
S
N
N
K
K
D
Q
D
T
S
S
Q
P
L
I
D
E
I
F
G
L
Y
S
P
F
Q
F
L
S
L
Q
G
I
G
K
C
F
Q
N
Y
R
S
K
S
K
C
E
I
F
P
R
T
300
301
A
K
E
T
I
Y
I
M
L
R
F
F
D
V
C
F
H
H
I
N
Q
G
C
V
S
I
A
N
P
L
E
N
Y
L
Q
K
M
N
L
L
P
S
T
P
S
S
I
S
S
A
G
S
P
N
T
A
H
T
K
S
360
361
H
V
A
L
V
I
N
H
L
P
Q
P
F
V
R
N
I
T
G
I
S
N
S
E
L
L
S
E
M
N
N
D
I
S
M
F
G
I
L
L
K
M
L
D
M
H
K
N
S
Y
Q
N
F
L
M
E
I
T
S
N
420
421
P
S
V
A
K
N
T
Q
S
I
D
V
L
Q
E
F
I
H
Y
C
Q
A
G
E
A
L
I
A
L
C
Y
S
Y
Y
N
S
T
L
Y
N
Y
V
D
F
T
C
D
I
T
H
L
E
Q
L
L
Y
F
L
D
L
480
481
L
F
W
L
S
E
I
Y
G
F
E
K
V
L
N
V
A
V
H
F
V
S
R
V
G
L
S
R
W
E
F
Y
V
G
L
D
E
N
F
A
E
R
R
R
N
L
W
W
K
A
F
Y
F
E
K
T
L
A
S
K
540
541
L
G
Y
P
S
N
I
D
D
S
K
I
N
C
L
L
P
K
N
F
R
D
V
G
F
L
D
N
R
D
F
I
E
N
V
H
L
V
R
R
S
E
A
F
D
N
M
C
I
S
D
L
K
Y
Y
G
E
L
A
V
600
601
L
Q
I
V
S
H
F
S
S
S
V
L
F
N
E
K
F
T
S
I
R
N
T
S
K
P
S
V
V
R
E
K
L
L
F
E
V
L
E
I
F
N
E
T
E
M
K
Y
D
A
I
K
E
Q
T
G
K
L
F
D
660
661
I
A
F
S
K
D
S
T
E
L
K
V
S
R
E
D
K
I
M
A
S
K
F
V
L
F
Y
E
H
H
F
C
R
M
V
N
E
S
D
N
I
V
A
R
L
C
V
H
R
R
P
S
I
L
I
E
N
L
K
I
720
721
Y
L
H
K
I
Y
K
S
W
T
D
M
N
K
I
L
L
D
F
D
N
D
Y
S
V
Y
R
S
F
A
H
Y
S
I
S
C
I
I
L
V
S
Q
A
F
S
V
A
E
F
I
K
V
N
D
V
V
N
M
I
R
780
781
V
F
K
R
F
L
D
I
K
I
F
S
E
N
E
T
N
E
H
V
F
N
S
Q
S
F
K
D
Y
T
R
A
F
S
F
L
T
I
V
T
R
I
M
L
L
A
Y
G
E
S
S
S
T
N
L
D
V
I
S
K
840
841
Y
I
D
E
N
A
P
D
L
K
G
I
I
E
L
V
L
D
T
N
S
C
A
Y
R
F
L
L
E
P
V
Q
K
S
G
F
H
L
T
V
S
Q
M
L
K
N
R
K
F
Q
E
P
L
M
S
N
E
D
N
K
900
901
Q
M
K
H
N
S
G
K
N
L
N
P
D
L
P
S
L
K
T
G
T
S
C
L
L
N
G
I
E
S
P
Q
L
P
F
N
G
R
S
A
P
S
P
V
R
N
N
S
L
P
E
F
A
Q
L
P
S
F
R
S
960
961
L
S
V
S
D
M
I
N
P
D
Y
A
Q
P
T
N
G
Q
N
N
T
Q
V
Q
S
N
K
P
I
N
A
Q
Q
Q
I
P
T
S
V
Q
V
P
F
M
N
T
N
E
I
N
N
N
N
N
N
N
N
N
N
K
1020
1021
N
N
I
N
N
I
N
N
N
N
S
N
N
F
S
A
T
S
F
N
L
G
T
L
D
E
F
V
N
N
G
D
L
E
D
L
Y
S
I
L
W
S
D
V
Y
P
D
S
1068
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0753
Peptide:
NNNKNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P12383
UniProt Name:
PDR1_YEAST
Protein Name:
Transcription factor PDR1 (Pleiotropic drug resistance protein 1)
Position:
1017-1022
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.31
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-123.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.41
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0754 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0754
Peptide:
NNNLQG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
107-112
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-68.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0755 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
L
D
Y
E
I
Y
K
E
G
G
I
L
N
N
R
Y
Q
K
I
E
D
I
S
E
G
S
Y
G
Y
V
S
L
A
K
D
V
R
E
K
R
L
V
A
V
K
Y
I
F
K
L
E
D
D
G
Q
Y
D
G
60
61
P
Q
D
D
E
N
D
C
D
S
S
D
C
D
D
D
E
D
T
K
V
D
T
D
R
H
E
N
E
N
G
N
A
S
S
N
N
G
S
S
R
E
K
K
H
N
L
Y
K
H
K
K
S
L
I
S
S
K
V
K
120
121
S
R
L
S
N
N
I
C
L
E
A
M
Y
E
V
D
I
Q
T
K
I
G
R
H
Q
N
I
A
A
L
L
D
F
F
D
S
Y
I
I
M
E
Y
C
S
G
G
D
L
Y
E
A
I
K
A
D
A
V
P
K
K
180
181
T
K
S
I
T
H
I
I
T
Q
I
M
D
A
I
E
Y
V
H
N
K
G
I
Y
H
R
D
I
K
P
E
N
I
L
I
S
G
I
D
W
T
I
K
L
T
D
W
G
L
A
T
T
D
K
T
S
M
D
R
N
240
241
V
G
S
E
R
Y
M
S
P
E
L
F
D
S
N
L
D
I
K
E
R
K
E
P
Y
D
C
A
K
V
D
L
W
A
M
G
I
V
F
L
N
I
V
F
H
K
N
P
F
S
I
A
N
Q
S
D
K
S
F
C
300
301
Y
F
A
A
N
R
E
A
L
F
D
V
F
S
T
M
A
Y
D
F
F
Q
V
L
R
Y
S
L
T
I
D
P
A
N
R
D
L
K
M
M
R
T
E
L
Q
N
L
S
E
Y
T
L
D
D
E
Y
Y
N
N
L
360
361
D
E
G
Y
E
E
T
M
I
D
G
L
P
P
Q
P
V
P
P
S
S
A
P
V
S
L
P
T
P
I
S
S
S
N
K
Q
H
M
P
E
F
K
K
D
F
N
F
N
N
V
N
E
R
K
R
S
D
V
S
Q
420
421
N
Q
N
V
A
S
G
F
F
K
K
P
S
T
Q
Q
Q
K
F
F
N
Q
G
Y
N
T
T
L
S
T
H
E
R
A
K
S
A
P
K
F
K
F
K
K
R
N
K
Y
G
R
T
D
N
Q
F
S
K
P
V
N
480
481
I
E
D
R
K
K
S
K
I
L
K
K
S
R
K
P
L
G
I
P
T
P
N
T
H
M
N
N
F
F
H
D
Y
K
A
R
D
E
F
N
T
R
D
F
F
T
P
P
S
V
Q
H
R
Y
M
E
G
F
S
N
540
541
N
N
N
K
Q
Y
R
Q
N
R
N
Y
N
N
N
N
N
N
S
N
N
N
H
G
S
N
Y
N
N
F
N
N
G
N
S
Y
I
K
G
W
N
K
N
F
N
K
Y
R
R
P
S
S
S
S
Y
T
G
K
S
P
600
601
L
S
R
Y
N
M
S
Y
N
H
N
N
N
S
S
I
N
G
Y
A
R
R
G
S
T
T
T
V
Q
H
S
P
G
A
Y
I
P
P
N
A
R
N
H
H
V
S
P
T
N
Q
F
L
R
V
P
Q
S
T
A
P
660
661
D
I
S
T
V
L
G
G
K
P
S
Y
Q
E
H
Y
T
Q
D
S
M
D
S
E
G
D
H
D
S
D
D
V
L
F
T
L
E
E
G
D
H
D
F
V
N
G
M
D
N
L
S
I
N
D
H
L
P
H
T
T
720
721
V
G
S
H
N
E
V
F
V
H
A
S
T
N
H
N
N
N
G
N
N
N
H
I
D
T
N
S
T
T
N
Q
Y
H
R
Q
Y
I
P
P
P
L
T
T
S
L
H
I
N
N
N
N
N
E
S
N
E
L
P
D
780
781
L
L
K
S
P
A
S
S
E
A
H
L
N
L
S
S
G
P
I
D
P
I
L
T
G
N
I
G
N
R
Y
S
H
S
S
D
S
K
E
L
E
Q
E
R
R
L
S
M
E
Q
K
F
K
N
G
V
Y
V
P
P
840
841
H
H
R
K
S
F
N
L
G
T
Q
V
P
P
M
N
M
K
T
S
N
E
A
T
L
S
V
S
H
N
S
V
N
F
G
G
S
Y
N
S
R
R
S
S
A
N
E
S
N
P
L
H
M
N
K
A
L
E
K
L
900
901
S
S
S
P
G
A
K
S
S
F
V
G
F
P
K
P
L
L
P
R
N
H
S
S
T
T
I
A
L
Q
N
E
D
V
F
A
D
S
N
N
D
A
I
I
F
E
D
E
E
Y
E
G
E
S
D
K
M
A
H
G
960
961
K
M
E
G
G
D
N
E
S
S
S
T
S
P
D
E
R
Q
I
F
G
P
Y
E
I
Y
A
Q
T
F
A
G
S
T
H
D
K
K
L
G
A
G
R
K
T
S
I
Q
D
E
M
V
G
S
L
E
Q
Y
K
N
1020
1021
N
W
L
I
L
Q
Q
Q
D
1029
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0755
Peptide:
NNNNNE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P38691
UniProt Name:
KSP1_YEAST
Protein Name:
Serine/threonine-protein kinase KSP1
Position:
769-774
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-132.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.09
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0756 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
F
F
N
L
N
N
N
N
N
N
N
N
T
T
T
T
T
T
T
T
N
N
N
N
T
N
N
N
N
T
N
N
N
N
N
P
A
N
N
T
N
N
N
N
S
T
G
H
S
S
N
T
N
N
N
T
N
N
60
61
N
N
T
N
T
G
A
S
G
V
D
D
F
Q
N
F
F
D
P
K
P
F
D
Q
N
L
D
S
N
N
N
N
S
N
S
N
N
N
D
N
N
N
S
N
T
V
A
S
S
T
N
F
T
S
P
T
A
V
V
N
120
121
N
A
A
P
A
N
V
T
G
G
K
A
A
N
F
I
Q
N
Q
S
P
Q
F
N
S
P
Y
D
S
N
N
S
N
T
N
L
N
S
L
S
P
Q
A
I
L
A
K
N
S
I
I
D
S
S
N
L
P
L
Q
A
180
181
Q
Q
Q
L
Y
G
G
N
N
N
N
N
S
T
G
I
A
N
D
N
V
I
T
P
H
F
I
T
N
V
Q
S
I
S
Q
N
S
S
S
S
T
P
N
T
N
S
N
S
T
P
N
A
N
Q
Q
F
L
P
F
N
240
241
N
S
A
S
N
N
G
N
L
T
S
N
Q
L
I
S
N
Y
A
A
S
N
S
M
D
R
S
S
S
A
S
N
E
F
V
P
N
T
S
D
N
N
N
N
S
N
N
H
N
M
R
N
N
S
N
N
K
T
S
N
300
301
N
N
N
V
T
A
V
P
A
A
T
P
A
N
T
N
N
S
T
S
N
A
N
T
V
F
S
E
R
A
A
M
F
A
A
L
Q
Q
K
Q
Q
Q
R
F
Q
A
L
Q
Q
Q
Q
Q
Q
Q
Q
N
Q
Q
Q
Q
360
361
N
Q
Q
P
Q
Q
Q
Q
Q
Q
Q
Q
N
P
K
F
L
Q
S
Q
R
Q
Q
Q
Q
R
S
I
L
Q
S
L
N
P
A
L
Q
E
K
I
S
T
E
L
N
N
K
Q
Y
E
L
F
M
K
S
L
I
E
N
C
420
421
K
K
R
N
M
P
L
Q
S
I
P
E
I
G
N
R
K
I
N
L
F
Y
L
Y
M
L
V
Q
K
F
G
G
A
D
Q
V
T
R
T
Q
Q
W
S
M
V
A
Q
R
L
Q
I
S
D
Y
Q
Q
L
E
S
I
480
481
Y
F
R
I
L
L
P
Y
E
R
H
M
I
S
Q
E
G
I
K
E
T
Q
A
K
R
I
F
L
Q
Q
F
L
Q
E
L
L
K
K
V
Q
Q
Q
Q
Q
A
A
A
L
A
N
A
N
N
N
I
N
S
A
S
S
540
541
A
P
T
P
A
A
P
G
A
S
V
P
A
T
A
A
P
G
T
E
A
G
I
V
P
V
S
A
N
T
P
K
S
L
N
S
N
I
N
I
N
V
N
N
N
N
I
G
Q
Q
Q
V
K
K
P
R
K
Q
R
V
600
601
K
K
K
T
K
K
E
L
E
L
E
R
K
E
R
E
D
F
Q
K
R
Q
Q
K
L
L
E
D
Q
Q
R
Q
Q
K
L
L
L
E
T
K
L
R
Q
Q
Y
E
I
E
L
K
K
L
P
K
V
Y
K
R
S
I
660
661
V
R
N
Y
K
P
L
I
N
R
L
K
H
Y
N
G
Y
D
I
N
Y
I
S
K
I
G
E
K
I
D
S
N
K
P
I
F
L
F
A
P
E
L
G
A
I
N
L
H
A
L
S
M
S
L
Q
S
K
N
L
G
720
721
E
I
N
T
A
L
N
T
L
L
V
T
S
A
D
S
N
L
K
I
S
L
V
K
Y
P
E
L
L
D
S
L
A
I
L
G
M
N
L
L
S
N
L
S
Q
N
V
V
P
Y
H
R
N
T
S
D
Y
Y
Y
E
780
781
D
A
G
S
N
Q
Y
Y
V
T
Q
H
D
K
M
V
D
K
I
F
E
K
V
N
N
N
A
T
L
T
P
N
D
S
N
D
E
K
V
T
I
L
V
D
S
L
T
G
N
Q
L
P
T
P
T
P
T
E
M
E
840
841
P
D
L
D
T
E
C
F
I
S
M
Q
S
T
S
P
A
V
K
Q
W
D
L
L
P
E
P
I
R
F
L
P
N
Q
F
P
L
K
I
H
R
T
P
Y
L
T
S
L
K
K
I
K
D
E
I
D
D
P
F
T
900
901
K
I
N
T
R
G
A
E
D
P
K
V
L
I
N
D
Q
L
S
T
I
S
M
I
L
R
N
I
S
F
S
D
N
N
S
R
I
M
S
R
N
F
Y
L
K
R
F
I
S
D
L
L
W
L
V
L
I
H
P
E
960
961
N
F
T
C
N
R
K
I
L
N
F
K
K
D
L
V
I
V
L
S
N
I
S
H
L
L
E
I
A
S
S
I
D
C
L
L
I
L
I
L
V
I
S
F
G
Q
P
K
L
N
P
M
A
S
S
S
S
F
G
S
1020
1021
E
S
L
T
F
N
E
F
Q
L
Q
W
G
K
Y
Q
T
F
G
V
D
I
L
A
K
L
F
S
L
E
K
P
N
L
N
Y
F
K
S
I
L
L
N
K
N
T
G
N
N
L
Y
D
R
N
S
N
N
N
H
K
1080
1081
D
K
K
L
L
R
R
L
L
N
L
Y
N
D
N
N
K
N
N
N
N
R
H
N
L
L
N
D
V
V
S
F
L
F
S
A
I
P
L
Q
Q
V
L
S
Q
S
A
D
P
S
L
L
I
D
Q
F
S
P
V
I
1140
1141
S
Q
S
L
T
S
I
L
V
I
V
Q
K
I
L
P
L
S
N
E
V
F
E
I
S
E
N
N
S
D
S
N
S
N
N
N
G
N
K
D
S
S
F
N
F
N
K
N
L
P
F
V
W
L
S
S
E
E
N
I
1200
1201
G
S
G
L
L
K
L
S
E
I
I
L
N
I
N
N
S
T
S
K
N
T
L
L
Q
Q
Q
N
Y
S
K
V
L
L
P
S
I
N
I
S
C
V
Q
L
I
K
C
L
V
E
K
S
I
C
F
E
N
C
L
N
1260
1261
N
D
P
E
I
L
K
K
I
A
S
I
P
N
L
F
P
T
D
L
E
I
F
Q
L
F
T
N
P
S
V
D
I
Q
I
I
N
Q
Y
Q
L
L
Y
N
L
K
N
D
I
L
T
N
L
E
1314
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0756
Peptide:
NNNNSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09547
UniProt Name:
SWI1_YEAST
Protein Name:
SWI/SNF chromatin-remodeling complex subunit SWI1
Position:
89-94
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-117.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.09
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0757 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
F
F
N
L
N
N
N
N
N
N
N
N
T
T
T
T
T
T
T
T
N
N
N
N
T
N
N
N
N
T
N
N
N
N
N
P
A
N
N
T
N
N
N
N
S
T
G
H
S
S
N
T
N
N
N
T
N
N
60
61
N
N
T
N
T
G
A
S
G
V
D
D
F
Q
N
F
F
D
P
K
P
F
D
Q
N
L
D
S
N
N
N
N
S
N
S
N
N
N
D
N
N
N
S
N
T
V
A
S
S
T
N
F
T
S
P
T
A
V
V
N
120
121
N
A
A
P
A
N
V
T
G
G
K
A
A
N
F
I
Q
N
Q
S
P
Q
F
N
S
P
Y
D
S
N
N
S
N
T
N
L
N
S
L
S
P
Q
A
I
L
A
K
N
S
I
I
D
S
S
N
L
P
L
Q
A
180
181
Q
Q
Q
L
Y
G
G
N
N
N
N
N
S
T
G
I
A
N
D
N
V
I
T
P
H
F
I
T
N
V
Q
S
I
S
Q
N
S
S
S
S
T
P
N
T
N
S
N
S
T
P
N
A
N
Q
Q
F
L
P
F
N
240
241
N
S
A
S
N
N
G
N
L
T
S
N
Q
L
I
S
N
Y
A
A
S
N
S
M
D
R
S
S
S
A
S
N
E
F
V
P
N
T
S
D
N
N
N
N
S
N
N
H
N
M
R
N
N
S
N
N
K
T
S
N
300
301
N
N
N
V
T
A
V
P
A
A
T
P
A
N
T
N
N
S
T
S
N
A
N
T
V
F
S
E
R
A
A
M
F
A
A
L
Q
Q
K
Q
Q
Q
R
F
Q
A
L
Q
Q
Q
Q
Q
Q
Q
Q
N
Q
Q
Q
Q
360
361
N
Q
Q
P
Q
Q
Q
Q
Q
Q
Q
Q
N
P
K
F
L
Q
S
Q
R
Q
Q
Q
Q
R
S
I
L
Q
S
L
N
P
A
L
Q
E
K
I
S
T
E
L
N
N
K
Q
Y
E
L
F
M
K
S
L
I
E
N
C
420
421
K
K
R
N
M
P
L
Q
S
I
P
E
I
G
N
R
K
I
N
L
F
Y
L
Y
M
L
V
Q
K
F
G
G
A
D
Q
V
T
R
T
Q
Q
W
S
M
V
A
Q
R
L
Q
I
S
D
Y
Q
Q
L
E
S
I
480
481
Y
F
R
I
L
L
P
Y
E
R
H
M
I
S
Q
E
G
I
K
E
T
Q
A
K
R
I
F
L
Q
Q
F
L
Q
E
L
L
K
K
V
Q
Q
Q
Q
Q
A
A
A
L
A
N
A
N
N
N
I
N
S
A
S
S
540
541
A
P
T
P
A
A
P
G
A
S
V
P
A
T
A
A
P
G
T
E
A
G
I
V
P
V
S
A
N
T
P
K
S
L
N
S
N
I
N
I
N
V
N
N
N
N
I
G
Q
Q
Q
V
K
K
P
R
K
Q
R
V
600
601
K
K
K
T
K
K
E
L
E
L
E
R
K
E
R
E
D
F
Q
K
R
Q
Q
K
L
L
E
D
Q
Q
R
Q
Q
K
L
L
L
E
T
K
L
R
Q
Q
Y
E
I
E
L
K
K
L
P
K
V
Y
K
R
S
I
660
661
V
R
N
Y
K
P
L
I
N
R
L
K
H
Y
N
G
Y
D
I
N
Y
I
S
K
I
G
E
K
I
D
S
N
K
P
I
F
L
F
A
P
E
L
G
A
I
N
L
H
A
L
S
M
S
L
Q
S
K
N
L
G
720
721
E
I
N
T
A
L
N
T
L
L
V
T
S
A
D
S
N
L
K
I
S
L
V
K
Y
P
E
L
L
D
S
L
A
I
L
G
M
N
L
L
S
N
L
S
Q
N
V
V
P
Y
H
R
N
T
S
D
Y
Y
Y
E
780
781
D
A
G
S
N
Q
Y
Y
V
T
Q
H
D
K
M
V
D
K
I
F
E
K
V
N
N
N
A
T
L
T
P
N
D
S
N
D
E
K
V
T
I
L
V
D
S
L
T
G
N
Q
L
P
T
P
T
P
T
E
M
E
840
841
P
D
L
D
T
E
C
F
I
S
M
Q
S
T
S
P
A
V
K
Q
W
D
L
L
P
E
P
I
R
F
L
P
N
Q
F
P
L
K
I
H
R
T
P
Y
L
T
S
L
K
K
I
K
D
E
I
D
D
P
F
T
900
901
K
I
N
T
R
G
A
E
D
P
K
V
L
I
N
D
Q
L
S
T
I
S
M
I
L
R
N
I
S
F
S
D
N
N
S
R
I
M
S
R
N
F
Y
L
K
R
F
I
S
D
L
L
W
L
V
L
I
H
P
E
960
961
N
F
T
C
N
R
K
I
L
N
F
K
K
D
L
V
I
V
L
S
N
I
S
H
L
L
E
I
A
S
S
I
D
C
L
L
I
L
I
L
V
I
S
F
G
Q
P
K
L
N
P
M
A
S
S
S
S
F
G
S
1020
1021
E
S
L
T
F
N
E
F
Q
L
Q
W
G
K
Y
Q
T
F
G
V
D
I
L
A
K
L
F
S
L
E
K
P
N
L
N
Y
F
K
S
I
L
L
N
K
N
T
G
N
N
L
Y
D
R
N
S
N
N
N
H
K
1080
1081
D
K
K
L
L
R
R
L
L
N
L
Y
N
D
N
N
K
N
N
N
N
R
H
N
L
L
N
D
V
V
S
F
L
F
S
A
I
P
L
Q
Q
V
L
S
Q
S
A
D
P
S
L
L
I
D
Q
F
S
P
V
I
1140
1141
S
Q
S
L
T
S
I
L
V
I
V
Q
K
I
L
P
L
S
N
E
V
F
E
I
S
E
N
N
S
D
S
N
S
N
N
N
G
N
K
D
S
S
F
N
F
N
K
N
L
P
F
V
W
L
S
S
E
E
N
I
1200
1201
G
S
G
L
L
K
L
S
E
I
I
L
N
I
N
N
S
T
S
K
N
T
L
L
Q
Q
Q
N
Y
S
K
V
L
L
P
S
I
N
I
S
C
V
Q
L
I
K
C
L
V
E
K
S
I
C
F
E
N
C
L
N
1260
1261
N
D
P
E
I
L
K
K
I
A
S
I
P
N
L
F
P
T
D
L
E
I
F
Q
L
F
T
N
P
S
V
D
I
Q
I
I
N
Q
Y
Q
L
L
Y
N
L
K
N
D
I
L
T
N
L
E
1314
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0757
Peptide:
NNNNTN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09547
UniProt Name:
SWI1_YEAST
Protein Name:
SWI/SNF chromatin-remodeling complex subunit SWI1
Position:
23-28
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-115.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.01
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0758 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
N
N
E
E
Q
H
Q
Q
Q
Q
Q
Q
Q
P
V
A
V
E
T
P
S
A
V
E
A
P
A
S
A
D
P
S
S
E
Q
S
V
A
V
E
G
N
S
E
Q
A
E
D
N
Q
G
E
N
D
P
S
V
60
61
V
P
A
N
A
I
T
G
G
R
E
T
S
D
R
V
L
Y
V
G
N
L
D
K
A
I
T
E
D
I
L
K
Q
Y
F
Q
V
G
G
P
I
A
N
I
K
I
M
I
D
K
N
N
K
N
V
N
Y
A
F
V
120
121
E
Y
H
Q
S
H
D
A
N
I
A
L
Q
T
L
N
G
K
Q
I
E
N
N
I
V
K
I
N
W
A
F
Q
S
Q
Q
S
S
S
D
D
T
F
N
L
F
V
G
D
L
N
V
N
V
D
D
E
T
L
R
N
180
181
A
F
K
D
F
P
S
Y
L
S
G
H
V
M
W
D
M
Q
T
G
S
S
R
G
Y
G
F
V
S
F
T
S
Q
D
D
A
Q
N
A
M
D
S
M
Q
G
Q
D
L
N
G
R
P
L
R
I
N
W
A
A
K
240
241
R
D
N
N
N
N
N
N
Y
Q
Q
R
R
N
Y
G
N
N
N
R
G
G
F
R
Q
Y
N
S
N
N
N
N
N
M
N
M
G
M
N
M
N
M
N
M
N
M
N
N
S
R
G
M
P
P
S
S
M
G
M
P
300
301
I
G
A
M
P
L
P
S
Q
G
Q
P
Q
Q
S
Q
T
I
G
L
P
P
Q
V
N
P
Q
A
V
D
H
I
I
R
S
A
P
P
R
V
T
T
A
Y
I
G
N
I
P
H
F
A
T
E
A
D
L
I
P
L
360
361
F
Q
N
F
G
F
I
L
D
F
K
H
Y
P
E
K
G
C
C
F
I
K
Y
D
T
H
E
Q
A
A
V
C
I
V
A
L
A
N
F
P
F
Q
G
R
N
L
R
T
G
W
G
K
E
R
S
N
F
M
P
Q
420
421
Q
Q
Q
Q
G
G
Q
P
L
I
M
N
D
Q
Q
Q
P
V
M
S
E
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
453
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0758
Peptide:
NNNRGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32588
UniProt Name:
PUB1_YEAST
Protein Name:
polyadenylated RNA-binding protein PUB1
Position:
257-262
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-111.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0759 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0759
Peptide:
NNNSSS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
48-53
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-87.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0760 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
H
Y
V
V
L
E
L
Q
V
A
H
L
P
D
T
P
K
D
Q
C
R
I
A
N
I
A
F
Q
I
V
N
A
E
T
L
V
C
H
Y
G
T
N
S
L
P
S
I
E
V
N
G
T
T
K
S
L
E
S
A
60
61
M
V
Q
L
D
K
D
I
H
D
V
I
G
N
D
D
F
V
L
V
S
L
Y
S
T
W
H
I
R
V
T
L
P
R
Q
A
R
D
D
G
F
I
L
T
S
Y
L
Q
H
P
K
V
F
D
L
W
K
E
F
D
120
121
R
W
C
V
N
H
P
E
I
L
G
Q
K
K
A
I
S
N
N
N
C
N
T
K
S
I
S
I
N
A
A
K
N
T
K
D
L
D
E
I
V
R
I
L
E
V
S
I
P
T
E
E
A
G
S
V
P
E
I
Y
180
181
S
L
L
K
R
T
T
D
I
L
I
Q
L
H
K
K
C
T
S
P
E
D
M
E
S
V
L
T
K
P
Y
D
S
H
T
D
I
R
A
F
L
Q
E
K
S
K
I
L
Y
M
N
N
L
P
P
D
T
T
Q
S
240
241
E
L
E
S
W
F
T
Q
Y
G
V
R
P
V
G
F
W
T
V
K
N
I
V
E
D
T
S
N
V
N
N
N
W
S
L
N
N
S
P
Y
V
E
D
Q
D
S
I
S
G
F
V
V
F
Q
T
H
E
E
A
T
300
301
E
V
L
A
L
N
G
R
S
I
L
S
N
L
A
N
T
K
Q
P
R
V
V
E
H
V
L
E
L
Q
P
S
S
T
G
V
L
D
K
A
Q
E
I
L
S
P
F
P
Q
S
K
N
K
P
R
P
G
D
W
N
360
361
C
P
S
C
G
F
S
N
F
Q
R
R
T
A
C
F
R
C
S
F
P
A
P
S
N
S
Q
I
H
T
A
N
S
N
N
N
V
N
S
S
R
N
N
L
N
N
R
V
N
S
G
S
S
S
N
I
S
N
T
A
420
421
A
N
H
P
Y
G
A
P
E
F
N
M
I
A
N
N
T
P
A
A
L
T
Y
N
R
A
H
F
P
A
I
T
P
L
S
R
Q
N
S
L
N
M
A
P
S
N
S
G
S
P
I
I
I
A
D
H
F
S
G
N
480
481
N
N
I
A
P
N
Y
R
Y
N
N
N
I
N
N
N
N
N
N
I
N
N
M
T
N
N
R
Y
N
I
N
N
N
I
N
G
N
G
N
G
N
G
N
N
S
N
N
N
N
N
H
N
N
N
H
N
N
N
H
H
540
541
N
G
S
I
N
S
N
S
N
T
N
N
N
N
N
N
N
N
G
N
N
S
N
N
C
N
S
N
I
G
M
G
G
C
G
S
N
M
P
F
R
A
G
D
W
K
C
S
T
C
T
Y
H
N
F
A
K
N
V
V
600
601
C
L
R
C
G
G
P
K
S
I
S
G
D
A
S
E
T
N
H
Y
I
D
S
S
T
F
G
P
A
S
R
T
P
S
N
N
N
I
S
V
N
T
N
G
G
S
N
A
G
R
T
D
G
N
D
N
K
G
R
D
660
661
I
S
L
M
E
F
M
S
P
P
L
S
M
A
T
K
S
M
K
E
G
D
G
N
G
S
S
F
N
E
F
K
S
D
K
A
N
V
N
F
S
N
V
G
D
N
S
A
F
G
N
G
F
N
S
S
I
R
W
719
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0760
Peptide:
NNNWSL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32770
UniProt Name:
NRP1_YEAST
Protein Name:
Asparagine-rich protein (Protein ARP)
Position:
270-275
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-43.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.97
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0761 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
V
K
S
H
I
G
S
W
I
L
V
L
F
V
A
M
W
S
D
V
G
L
C
K
K
R
P
K
P
G
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
60
61
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
G
W
G
Q
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
V
A
G
A
A
A
120
121
A
G
A
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
L
I
H
F
G
N
D
Y
E
D
R
Y
Y
R
E
N
M
Y
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
N
N
Q
N
T
F
V
H
180
181
D
C
V
N
I
T
V
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
I
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
Q
R
E
S
E
A
Y
Y
Q
R
G
A
S
V
I
L
F
S
S
240
241
P
P
V
I
L
L
I
S
F
L
I
F
L
I
V
G
256
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0761
Peptide:
NNQNTF
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
3FVA
Protein Information
UniProt ID:
P67986
UniProt Name:
PRIO_CEREN
Protein Name:
Major prion protein (PrP) (CD antigen CD230)
Position:
173-178
Literature
PMID:
19684598
Reference:
Nat Struct Mol Biol. 2009 Sep;16(9):973-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.3
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-83.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.49
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0762 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0762
Peptide:
NNQQNY
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
8-13
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-103.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0763 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0763
Peptide:
NNRYQG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
26-31
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-71.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.18
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0764 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0764
Peptide:
NNSGPN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
37-42
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.6
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-82.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.04
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0765 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0765
Peptide:
NNSYSG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
371-376
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-40.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0766 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0766
Peptide:
NNTIFV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
284-289
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.1
Area of the profile Above Threshold (AGGRESCAN):
2.56
Best Energy Score (PASTA 2.0):
-4.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0767 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0767
Peptide:
NPAMMA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
319-324
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.3
Area of the profile Above Threshold (AGGRESCAN):
0.66
Best Energy Score (PASTA 2.0):
0.53
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0768 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0768
Peptide:
NPDAGY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
64-69
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-68.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0769 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0769
Peptide:
NPQGGR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
93-98
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.64
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-90.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.07
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0770 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0770
Peptide:
NPQGGY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
74-79
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-66.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.99
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0771 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
V
W
D
R
Q
T
K
M
E
Y
E
W
K
P
D
E
Q
G
L
Q
Q
I
L
Q
L
L
K
E
S
Q
S
P
D
T
T
I
Q
R
T
V
Q
Q
K
L
E
Q
L
N
Q
Y
P
D
F
N
N
Y
L
I
F
60
61
V
L
T
K
L
K
S
E
D
E
P
T
R
S
L
S
G
L
I
L
K
N
N
V
K
A
H
F
Q
N
F
P
N
G
V
T
D
F
I
K
S
E
C
L
N
N
I
G
D
S
S
P
L
I
R
A
T
V
G
I
120
121
L
I
T
T
I
A
S
K
G
E
L
Q
N
W
P
D
L
L
P
K
L
C
S
L
L
D
S
E
D
Y
N
T
C
E
G
A
F
G
A
L
Q
K
I
C
E
D
S
A
E
I
L
D
S
D
V
L
D
R
P
L
180
181
N
I
M
I
P
K
F
L
Q
F
F
K
H
S
S
P
K
I
R
S
H
A
V
A
C
V
N
Q
F
I
I
S
R
T
Q
A
L
M
L
H
I
D
S
F
I
E
N
L
F
A
L
A
G
D
E
E
P
E
V
R
240
241
K
N
V
C
R
A
L
V
M
L
L
E
V
R
M
D
R
L
L
P
H
M
H
N
I
V
E
Y
M
L
Q
R
T
Q
D
Q
D
E
N
V
A
L
E
A
C
E
F
W
L
T
L
A
E
Q
P
I
C
K
D
V
300
301
L
V
R
H
L
P
K
L
I
P
V
L
V
N
G
M
K
Y
S
D
I
D
I
I
L
L
K
G
D
V
E
E
D
E
T
I
P
D
S
E
Q
D
I
R
P
R
F
H
R
S
R
T
V
A
Q
Q
H
D
E
D
360
361
G
I
E
E
E
D
D
D
D
D
E
I
D
D
D
D
T
I
S
D
W
N
L
R
K
C
S
A
A
A
L
D
V
L
A
N
V
Y
R
D
E
L
L
P
H
I
L
P
L
L
K
E
L
L
F
H
H
E
W
V
420
421
V
K
E
S
G
I
L
V
L
G
A
I
A
E
G
C
M
Q
G
M
I
P
Y
L
P
E
L
I
P
H
L
I
Q
C
L
S
D
K
K
A
L
V
R
S
I
T
C
W
T
L
S
R
Y
A
H
W
V
V
S
Q
480
481
P
P
D
T
Y
L
K
P
L
M
T
E
L
L
K
R
I
L
D
S
N
K
R
V
Q
E
A
A
C
S
A
F
A
T
L
E
E
E
A
C
T
E
L
V
P
Y
L
A
Y
I
L
D
T
L
V
F
A
F
S
K
540
541
Y
Q
H
K
N
L
L
I
L
Y
D
A
I
G
T
L
A
D
S
V
G
H
H
L
N
K
P
E
Y
I
Q
M
L
M
P
P
L
I
Q
K
W
N
M
L
K
D
E
D
K
D
L
F
P
L
L
E
C
L
S
S
600
601
V
A
T
A
L
Q
S
G
F
L
P
Y
C
E
P
V
Y
Q
R
C
V
N
L
V
Q
K
T
L
A
Q
A
M
L
N
N
A
Q
P
D
Q
Y
E
A
P
D
K
D
F
M
I
V
A
L
D
L
L
S
G
L
A
660
661
E
G
L
G
G
N
I
E
Q
L
V
A
R
S
N
I
L
T
L
M
Y
Q
C
M
Q
D
K
M
P
E
V
R
Q
S
S
F
A
L
L
G
D
L
T
K
A
C
F
Q
H
V
K
P
C
I
A
D
F
M
P
I
720
721
L
G
T
N
L
N
P
E
F
I
S
V
C
N
N
A
T
W
A
I
G
E
I
S
I
Q
M
G
I
E
M
Q
P
Y
I
P
M
V
L
H
Q
L
V
E
I
I
N
R
P
N
T
P
K
T
L
L
E
N
T
A
780
781
I
T
I
G
R
L
G
Y
V
C
P
Q
E
V
A
P
M
L
Q
Q
F
I
R
P
W
C
T
S
L
R
N
I
R
D
N
E
E
K
D
S
A
F
R
G
I
C
T
M
I
S
V
N
P
S
G
V
I
Q
D
F
840
841
I
F
F
C
D
A
V
A
S
W
I
N
P
K
D
D
L
R
D
M
F
C
K
I
L
H
G
F
K
N
Q
V
G
D
E
N
W
R
R
F
S
D
Q
F
P
L
P
L
K
E
R
L
A
A
F
Y
G
V
898
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0771
Peptide:
NQFIIS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q92973
UniProt Name:
TNPO1_HUMAN
Protein Name:
Transportin-1 (Importin beta-2)
Position:
207-212
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.81
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
45.4
Area of the profile Above Threshold (AGGRESCAN):
3.04
Best Energy Score (PASTA 2.0):
-4.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0772 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
K
F
A
Y
C
K
V
V
L
A
T
S
L
I
W
V
L
L
D
M
F
L
L
L
Y
F
S
E
C
N
K
C
D
E
K
K
E
R
G
L
P
A
G
D
V
L
E
P
V
Q
K
P
H
E
G
P
G
E
60
61
M
G
K
P
V
V
I
P
K
E
D
Q
E
K
M
K
E
M
F
K
I
N
Q
F
N
L
M
A
S
E
M
I
A
L
N
R
S
L
P
D
V
R
L
E
G
C
K
T
K
V
Y
P
D
N
L
P
T
T
S
V
120
121
V
I
V
F
H
N
E
A
W
S
T
L
L
R
T
V
H
S
V
I
N
R
S
P
R
H
M
I
E
E
I
V
L
V
D
D
A
S
E
R
D
F
L
K
R
P
L
E
S
Y
V
K
K
L
K
V
P
V
H
V
180
181
I
R
M
E
Q
R
S
G
L
I
R
A
R
L
K
G
A
A
V
S
K
G
Q
V
I
T
F
L
D
A
H
C
E
C
T
V
G
W
L
E
P
L
L
A
R
I
K
H
D
R
R
T
V
V
C
P
I
I
D
V
240
241
I
S
D
D
T
F
E
Y
M
A
G
S
D
M
T
Y
G
G
F
N
W
K
L
N
F
R
W
Y
P
V
P
Q
R
E
M
D
R
R
K
G
D
R
T
L
P
V
R
T
P
T
M
A
G
G
L
F
S
I
D
R
300
301
D
Y
F
Q
E
I
G
T
Y
D
A
G
M
D
I
W
G
G
E
N
L
E
I
S
F
R
I
W
Q
C
G
G
T
L
E
I
V
T
C
S
H
V
G
H
V
F
R
K
A
T
P
Y
T
F
P
G
G
T
G
Q
360
361
I
I
N
K
N
N
R
R
L
A
E
V
W
M
D
E
F
K
N
F
F
Y
I
I
S
P
G
V
T
K
V
D
Y
G
D
I
S
S
R
V
G
L
R
H
K
L
Q
C
K
P
F
S
W
Y
L
E
N
I
Y
P
420
421
D
S
Q
I
P
R
H
Y
F
S
L
G
E
I
R
N
V
E
T
N
Q
C
L
D
N
M
A
R
K
E
N
E
K
V
G
I
F
N
C
H
G
M
G
G
N
Q
V
F
S
Y
T
A
N
K
E
I
R
T
D
D
480
481
L
C
L
D
V
S
K
L
N
G
P
V
T
M
L
K
C
H
H
L
K
G
N
Q
L
W
E
Y
D
P
V
K
L
T
L
Q
H
V
N
S
N
Q
C
L
D
K
A
T
E
E
D
S
Q
V
P
S
I
R
D
C
540
541
N
G
S
R
S
Q
Q
W
L
L
R
N
V
T
L
P
E
I
F
559
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0772
Peptide:
NQFNLM
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q10472
UniProt Name:
GALT1_HUMAN
Protein Name:
Polypeptide N-acetylgalactosaminyltransferase 1
Position:
82-87
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.0
Area of the profile Above Threshold (AGGRESCAN):
1.02
Best Energy Score (PASTA 2.0):
-1.8
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0773 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0773
Peptide:
NQGNNQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
5-10
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-113.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.52
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0774 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
L
D
Y
E
I
Y
K
E
G
G
I
L
N
N
R
Y
Q
K
I
E
D
I
S
E
G
S
Y
G
Y
V
S
L
A
K
D
V
R
E
K
R
L
V
A
V
K
Y
I
F
K
L
E
D
D
G
Q
Y
D
G
60
61
P
Q
D
D
E
N
D
C
D
S
S
D
C
D
D
D
E
D
T
K
V
D
T
D
R
H
E
N
E
N
G
N
A
S
S
N
N
G
S
S
R
E
K
K
H
N
L
Y
K
H
K
K
S
L
I
S
S
K
V
K
120
121
S
R
L
S
N
N
I
C
L
E
A
M
Y
E
V
D
I
Q
T
K
I
G
R
H
Q
N
I
A
A
L
L
D
F
F
D
S
Y
I
I
M
E
Y
C
S
G
G
D
L
Y
E
A
I
K
A
D
A
V
P
K
K
180
181
T
K
S
I
T
H
I
I
T
Q
I
M
D
A
I
E
Y
V
H
N
K
G
I
Y
H
R
D
I
K
P
E
N
I
L
I
S
G
I
D
W
T
I
K
L
T
D
W
G
L
A
T
T
D
K
T
S
M
D
R
N
240
241
V
G
S
E
R
Y
M
S
P
E
L
F
D
S
N
L
D
I
K
E
R
K
E
P
Y
D
C
A
K
V
D
L
W
A
M
G
I
V
F
L
N
I
V
F
H
K
N
P
F
S
I
A
N
Q
S
D
K
S
F
C
300
301
Y
F
A
A
N
R
E
A
L
F
D
V
F
S
T
M
A
Y
D
F
F
Q
V
L
R
Y
S
L
T
I
D
P
A
N
R
D
L
K
M
M
R
T
E
L
Q
N
L
S
E
Y
T
L
D
D
E
Y
Y
N
N
L
360
361
D
E
G
Y
E
E
T
M
I
D
G
L
P
P
Q
P
V
P
P
S
S
A
P
V
S
L
P
T
P
I
S
S
S
N
K
Q
H
M
P
E
F
K
K
D
F
N
F
N
N
V
N
E
R
K
R
S
D
V
S
Q
420
421
N
Q
N
V
A
S
G
F
F
K
K
P
S
T
Q
Q
Q
K
F
F
N
Q
G
Y
N
T
T
L
S
T
H
E
R
A
K
S
A
P
K
F
K
F
K
K
R
N
K
Y
G
R
T
D
N
Q
F
S
K
P
V
N
480
481
I
E
D
R
K
K
S
K
I
L
K
K
S
R
K
P
L
G
I
P
T
P
N
T
H
M
N
N
F
F
H
D
Y
K
A
R
D
E
F
N
T
R
D
F
F
T
P
P
S
V
Q
H
R
Y
M
E
G
F
S
N
540
541
N
N
N
K
Q
Y
R
Q
N
R
N
Y
N
N
N
N
N
N
S
N
N
N
H
G
S
N
Y
N
N
F
N
N
G
N
S
Y
I
K
G
W
N
K
N
F
N
K
Y
R
R
P
S
S
S
S
Y
T
G
K
S
P
600
601
L
S
R
Y
N
M
S
Y
N
H
N
N
N
S
S
I
N
G
Y
A
R
R
G
S
T
T
T
V
Q
H
S
P
G
A
Y
I
P
P
N
A
R
N
H
H
V
S
P
T
N
Q
F
L
R
V
P
Q
S
T
A
P
660
661
D
I
S
T
V
L
G
G
K
P
S
Y
Q
E
H
Y
T
Q
D
S
M
D
S
E
G
D
H
D
S
D
D
V
L
F
T
L
E
E
G
D
H
D
F
V
N
G
M
D
N
L
S
I
N
D
H
L
P
H
T
T
720
721
V
G
S
H
N
E
V
F
V
H
A
S
T
N
H
N
N
N
G
N
N
N
H
I
D
T
N
S
T
T
N
Q
Y
H
R
Q
Y
I
P
P
P
L
T
T
S
L
H
I
N
N
N
N
N
E
S
N
E
L
P
D
780
781
L
L
K
S
P
A
S
S
E
A
H
L
N
L
S
S
G
P
I
D
P
I
L
T
G
N
I
G
N
R
Y
S
H
S
S
D
S
K
E
L
E
Q
E
R
R
L
S
M
E
Q
K
F
K
N
G
V
Y
V
P
P
840
841
H
H
R
K
S
F
N
L
G
T
Q
V
P
P
M
N
M
K
T
S
N
E
A
T
L
S
V
S
H
N
S
V
N
F
G
G
S
Y
N
S
R
R
S
S
A
N
E
S
N
P
L
H
M
N
K
A
L
E
K
L
900
901
S
S
S
P
G
A
K
S
S
F
V
G
F
P
K
P
L
L
P
R
N
H
S
S
T
T
I
A
L
Q
N
E
D
V
F
A
D
S
N
N
D
A
I
I
F
E
D
E
E
Y
E
G
E
S
D
K
M
A
H
G
960
961
K
M
E
G
G
D
N
E
S
S
S
T
S
P
D
E
R
Q
I
F
G
P
Y
E
I
Y
A
Q
T
F
A
G
S
T
H
D
K
K
L
G
A
G
R
K
T
S
I
Q
D
E
M
V
G
S
L
E
Q
Y
K
N
1020
1021
N
W
L
I
L
Q
Q
Q
D
1029
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0774
Peptide:
NQGYNT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P38691
UniProt Name:
KSP1_YEAST
Protein Name:
Serine/threonine-protein kinase KSP1
Position:
441-446
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0775 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0775
Peptide:
NQIVYK
Length:
6
Classification:
amyloid
Mutation(s):
V623N
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.24
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.0
Area of the profile Above Threshold (AGGRESCAN):
2.0
Best Energy Score (PASTA 2.0):
-3.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0776 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
L
Y
L
L
T
N
A
K
G
Q
Q
M
Q
I
E
L
K
N
G
E
I
I
Q
G
I
L
T
N
V
D
N
W
M
N
L
T
L
S
N
V
T
E
Y
S
E
E
S
A
I
N
S
E
D
N
A
E
S
60
61
S
K
A
V
K
L
N
E
I
Y
I
R
G
T
F
I
K
F
I
K
L
Q
D
N
I
I
D
K
V
K
Q
Q
I
N
S
N
N
N
S
N
S
N
G
P
G
H
K
R
Y
Y
N
N
R
D
S
N
N
N
R
G
120
121
N
Y
N
R
R
N
N
N
N
G
N
S
N
R
R
P
Y
S
Q
N
R
Q
Y
N
N
S
N
S
S
N
I
N
N
S
I
N
S
I
N
S
N
N
Q
N
M
N
N
G
L
G
G
S
V
Q
H
H
F
N
S
S
180
181
S
P
Q
K
V
E
F
187
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0776
Peptide:
NQNMNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P40070
UniProt Name:
LSM4_YEAST
Protein Name:
U6 snRNA-associated Sm-like protein LSm4
Position:
162-167
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-85.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0777 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0777
Peptide:
NQNNFV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
171-176
Literature
PMID:
14691246
Reference:
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.2
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-2.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0778 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0778
Peptide:
NQQNQY
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-103.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0779 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0779
Peptide:
NQQNYQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
9-14
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-95.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0780 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0780
Peptide:
NQQQGN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
21-26
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-116.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.45
Aggregate Orientation (PASTA 2.0):
Antiparallel
