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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1441 to 1470 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1441
YYNYNN
6
Non-amyloid
Negative growth regulatory protein NGR1 (RNA-binding protein RBP1)
P32831
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-1442
YYQNYQ
6
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
Nat Methods. 2010 Mar;7(3):237-42.
20154676
WALTZ
P-1443
YYTEFT
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-1444
AEVSIVV
7
Amyloid
Melanocyte protein PMEL (ME20-M)
P40967
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1445
AIAAIVF
7
Amyloid
Major curlin subunit
P28307
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1446
ANQNNFV
7
Amyloid
Major prion protein (PrP)
P04156
Nat Methods. 2010 Mar;7(3):237-42.
20154676
WALTZ
P-1447
ATKHKIP
7
Non-amyloid
Myoglobin
P02185
No
Protein Sci. 1997 Mar;6(3):706-16.
9070453
AmyLoad
P-1448
CQVNIGN
7
Amyloid
Transcriptional regulator URE2
P23202
No
Fei L, Perrett S
19258323
CPAD
P-1449
DAQAIAL
7
Amyloid
Chorion protein S18
P07184
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1450
DFVIFLD
7
Amyloid
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
P02489
K70D
Biochemistry. 2008 Mar 4;47(9):2961-7.
18232642
CPAD
P-1451
EFQEICA
7
Amyloid
Hydrophobin 4
Q6YF29
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1452
FNGLIVV
7
Amyloid
Hydrophobin
O60048
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1453
GILNIVV
7
Amyloid
Hydrophobin
Q8WZI5
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1454
GLINIAT
7
Amyloid
Hydrophobin
Q8J0V5
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1455
GLSAPVD
7
Non-amyloid
Myohemerythrin (MHr)
P02247
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
AmyLoad
P-1456
GNNQQNY
7
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD, AmyLoad
P-1457
GQVIWVN
7
Amyloid
Melanocyte protein PMEL (ME20-M)
P40967
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1458
GTYSFYT
7
Amyloid
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
CPAD, AmyLoad
P-1459
GVVAIGC
7
Amyloid
Hydrophobin
Q8WZJ3
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1460
IFKINVK
7
Amyloid
Lysozyme C
P61626
Q76K, S79V, R80K
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1461
IIHFGSD
7
Amyloid
Major prion protein (PrP)
P04156
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
P-1462
KLVFFAE
7
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 2000 Nov 14;39(45):13748-59.
11076514
CPAD
P-1463
KLVFFAK
7
Amyloid
Amyloid-beta precursor protein (APP)
P05067
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1464
KMVLYTL
7
Amyloid
CPAD
P-1465
KNFNYNI
7
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
Nat Methods. 2010 Mar;7(3):237-42.
20154676
WALTZ
P-1466
KNNQKNY
7
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
G7K, Q11K
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1467
LASLIYR
7
Amyloid
Melanocyte protein PMEL (ME20-M)
P40967
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1468
LKQALKL
7
Amyloid
Alpha-synuclein
P37840
V12K, E13Q, Y16K
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1469
LVEALYL
7
Amyloid
Insulin
P01308
No
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1470
MIHFGND
7
Amyloid
Major prion protein (PrP)
P04925
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
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Entry: P-1441 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
M
S
N
V
A
N
A
S
Q
R
Q
E
N
P
Y
I
I
P
L
P
P
S
S
T
V
E
T
S
T
E
P
P
R
T
L
W
M
G
D
L
D
P
S
F
D
E
A
T
I
E
E
I
W
S
K
L
D
K
K
60
61
V
I
V
K
L
I
R
A
K
K
N
L
L
I
P
C
S
S
T
S
S
S
N
N
N
T
S
E
E
N
A
E
N
Q
Q
S
A
S
N
S
T
D
Q
L
D
N
S
Q
M
I
N
I
N
G
I
S
F
I
D
P
120
121
S
T
T
Q
L
H
H
A
G
Y
C
F
V
E
F
E
T
Q
K
D
A
K
F
A
L
S
L
N
A
T
P
L
P
N
F
Y
S
P
T
T
N
S
Q
T
N
P
T
F
K
R
T
F
R
L
N
W
A
S
G
A
180
181
T
L
Q
S
S
I
P
S
T
P
E
F
S
L
F
V
G
D
L
S
P
T
A
T
E
A
D
L
L
S
L
F
Q
T
R
F
K
S
V
K
T
V
R
V
M
T
D
P
L
T
G
S
S
R
C
F
G
F
V
R
240
241
F
G
D
E
D
E
R
R
R
A
L
I
E
M
S
G
K
W
F
Q
G
R
A
L
R
V
A
Y
A
T
P
R
N
N
M
M
L
Q
L
Q
E
Q
Q
Q
Q
Q
Q
Q
L
Q
Q
Q
H
Q
Q
L
D
Q
E
D
300
301
N
N
G
P
L
L
I
K
T
A
N
N
L
I
Q
N
N
S
N
M
L
P
L
N
A
L
H
N
A
P
P
M
H
L
N
E
G
G
I
S
N
M
R
V
N
D
S
L
P
S
N
T
Y
N
T
D
P
T
N
T
360
361
T
V
F
V
G
G
L
V
P
K
T
T
E
F
Q
L
R
S
L
F
K
P
F
G
P
I
L
N
V
R
I
P
N
G
K
N
C
G
F
V
K
F
E
K
R
I
D
A
E
A
S
I
Q
G
L
Q
G
F
I
V
420
421
G
G
S
P
I
R
L
S
W
G
R
P
S
S
S
N
A
K
T
N
S
T
I
M
G
A
S
Q
Y
M
S
S
N
G
L
R
A
P
S
A
A
S
S
V
D
N
S
K
Q
I
L
E
Q
Y
A
E
D
K
R
R
480
481
L
F
L
H
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
D
G
N
F
S
M
E
Q
M
A
H
N
N
Y
Y
N
Y
N
N
Y
D
Y
H
R
N
K
N
G
S
H
S
D
L
V
N
L
Q
R
S
N
V
P
Y
M
Q
540
541
E
D
G
A
L
Y
P
H
Q
Y
S
S
P
S
Y
S
L
H
P
T
G
N
Q
F
S
N
A
T
N
N
L
P
Q
F
G
N
A
M
S
I
S
M
Q
L
P
N
G
N
S
N
K
T
A
S
S
M
N
T
N
P
600
601
N
T
N
M
I
M
N
S
N
M
N
M
N
M
N
V
N
P
V
P
Y
G
M
G
N
G
A
N
M
Y
D
V
S
R
M
M
T
P
P
L
N
I
A
P
N
S
N
N
S
K
S
S
I
M
N
K
H
P
N
R
660
661
N
N
V
P
P
I
H
P
S
L
L
H
672
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1441
Peptide:
YYNYNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32831
UniProt Name:
NGR1_YEAST
Protein Name:
Negative growth regulatory protein NGR1 (RNA-binding protein RBP1)
Position:
509-514
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.3
Area of the profile Above Threshold (AGGRESCAN):
0.52
Best Energy Score (PASTA 2.0):
-1.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1442 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1442
Peptide:
YYQNYQ
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
45-50
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
WALTZ
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.5
Area of the profile Above Threshold (AGGRESCAN):
0.21
Best Energy Score (PASTA 2.0):
-0.74
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1443 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1443
Peptide:
YYTEFT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
86-91
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.16
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.6
Area of the profile Above Threshold (AGGRESCAN):
0.78
Best Energy Score (PASTA 2.0):
-2.35
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1444 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
L
V
L
K
R
C
L
L
H
L
A
V
I
G
A
L
L
A
V
G
A
T
K
V
P
R
N
Q
D
W
L
G
V
S
R
Q
L
R
T
K
A
W
N
R
Q
L
Y
P
E
W
T
E
A
Q
R
L
D
C
60
61
W
R
G
G
Q
V
S
L
K
V
S
N
D
G
P
T
L
I
G
A
N
A
S
F
S
I
A
L
N
F
P
G
S
Q
K
V
L
P
D
G
Q
V
I
W
V
N
N
T
I
I
N
G
S
Q
V
W
G
G
Q
P
120
121
V
Y
P
Q
E
T
D
D
A
C
I
F
P
D
G
G
P
C
P
S
G
S
W
S
Q
K
R
S
F
V
Y
V
W
K
T
W
G
Q
Y
W
Q
V
L
G
G
P
V
S
G
L
S
I
G
T
G
R
A
M
L
G
180
181
T
H
T
M
E
V
T
V
Y
H
R
R
G
S
R
S
Y
V
P
L
A
H
S
S
S
A
F
T
I
T
D
Q
V
P
F
S
V
S
V
S
Q
L
R
A
L
D
G
G
N
K
H
F
L
R
N
Q
P
L
T
F
240
241
A
L
Q
L
H
D
P
S
G
Y
L
A
E
A
D
L
S
Y
T
W
D
F
G
D
S
S
G
T
L
I
S
R
A
L
V
V
T
H
T
Y
L
E
P
G
P
V
T
A
Q
V
V
L
Q
A
A
I
P
L
T
S
300
301
C
G
S
S
P
V
P
G
T
T
D
G
H
R
P
T
A
E
A
P
N
T
T
A
G
Q
V
P
T
T
E
V
V
G
T
T
P
G
Q
A
P
T
A
E
P
S
G
T
T
S
V
Q
V
P
T
T
E
V
I
S
360
361
T
A
P
V
Q
M
P
T
A
E
S
T
G
M
T
P
E
K
V
P
V
S
E
V
M
G
T
T
L
A
E
M
S
T
P
E
A
T
G
M
T
P
A
E
V
S
I
V
V
L
S
G
T
T
A
A
Q
V
T
T
420
421
T
E
W
V
E
T
T
A
R
E
L
P
I
P
E
P
E
G
P
D
A
S
S
I
M
S
T
E
S
I
T
G
S
L
G
P
L
L
D
G
T
A
T
L
R
L
V
K
R
Q
V
P
L
D
C
V
L
Y
R
Y
480
481
G
S
F
S
V
T
L
D
I
V
Q
G
I
E
S
A
E
I
L
Q
A
V
P
S
G
E
G
D
A
F
E
L
T
V
S
C
Q
G
G
L
P
K
E
A
C
M
E
I
S
S
P
G
C
Q
P
P
A
Q
R
L
540
541
C
Q
P
V
L
P
S
P
A
C
Q
L
V
L
H
Q
I
L
K
G
G
S
G
T
Y
C
L
N
V
S
L
A
D
T
N
S
L
A
V
V
S
T
Q
L
I
M
P
G
Q
E
A
G
L
G
Q
V
P
L
I
V
600
601
G
I
L
L
V
L
M
A
V
V
L
A
S
L
I
Y
R
R
R
L
M
K
Q
D
F
S
V
P
Q
L
P
H
S
S
S
H
W
L
R
L
P
R
I
F
C
S
C
P
I
G
E
N
S
P
L
L
S
G
Q
Q
660
661
V
661
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1444
Peptide:
AEVSIVV
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P40967
UniProt Name:
PMEL_HUMAN
Protein Name:
Melanocyte protein PMEL (ME20-M)
Position:
403-409
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
71.43
NuAPRpred:
1.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
42.9
Area of the profile Above Threshold (AGGRESCAN):
3.81
Best Energy Score (PASTA 2.0):
-7.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1445 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1445
Peptide:
AIAAIVF
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
8-14
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
2.04
Tango:
439.02
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
63.1
Area of the profile Above Threshold (AGGRESCAN):
4.58
Best Energy Score (PASTA 2.0):
-5.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1446 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1446
Peptide:
ANQNNFV
Length:
7
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
WALTZ
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
42.86
NuAPRpred:
0.04
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-59.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-2.85
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1447 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
L
S
E
G
E
W
Q
L
V
L
H
V
W
A
K
V
E
A
D
V
A
G
H
G
Q
D
I
L
I
R
L
F
K
S
H
P
E
T
L
E
K
F
D
R
F
K
H
L
K
T
E
A
E
M
K
A
S
E
60
61
D
L
K
K
H
G
V
T
V
L
T
A
L
G
A
I
L
K
K
K
G
H
H
E
A
E
L
K
P
L
A
Q
S
H
A
T
K
H
K
I
P
I
K
Y
L
E
F
I
S
E
A
I
I
H
V
L
H
S
R
H
120
121
P
G
D
F
G
A
D
A
Q
G
A
M
N
K
A
L
E
L
F
R
K
D
I
A
A
K
Y
K
E
L
G
Y
Q
G
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1447
Peptide:
ATKHKIP
Length:
7
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02185
UniProt Name:
MYG_PHYMC
Protein Name:
Myoglobin
Position:
95-101
Literature
PMID:
9070453
Reference:
Protein Sci. 1997 Mar;6(3):706-16.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
42.86
NuAPRpred:
-0.69
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-46.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.07
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1448 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1448
Peptide:
CQVNIGN
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
17-23
Literature
PMID:
19258323
Reference:
Fei L, Perrett S
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
42.86
NuAPRpred:
0.96
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.9
Area of the profile Above Threshold (AGGRESCAN):
0.48
Best Energy Score (PASTA 2.0):
-2.62
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1449 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
M
K
F
M
C
I
C
L
C
A
I
S
A
V
S
A
N
S
Y
G
R
S
R
G
G
Y
G
G
A
P
V
G
G
Y
A
Y
Q
V
Q
P
A
L
T
V
K
A
I
V
P
S
Y
G
G
G
Y
G
G
N
H
60
61
G
G
Y
G
G
A
Y
E
S
V
P
V
P
V
S
S
A
Y
S
G
A
N
V
G
S
Q
Y
S
G
S
G
Y
G
G
A
P
P
V
D
A
Q
A
I
A
L
A
K
L
A
L
A
A
P
S
A
G
A
P
L
V
120
121
W
K
E
A
P
R
Y
A
Q
P
V
Y
P
P
T
S
Y
V
N
Q
E
Y
G
H
S
E
K
V
K
G
G
S
A
A
A
A
A
S
S
V
A
A
G
K
K
G
Y
K
R
P
S
Y
172
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1449
Peptide:
DAQAIAL
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P07184
UniProt Name:
CH18_DROME
Protein Name:
Chorion protein S18
Position:
99-105
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
71.43
NuAPRpred:
0.0
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.5
Area of the profile Above Threshold (AGGRESCAN):
1.37
Best Energy Score (PASTA 2.0):
-1.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1450 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
T
I
Q
H
P
W
F
K
R
T
L
G
P
F
Y
P
S
R
L
F
D
Q
F
F
G
E
G
L
F
E
Y
D
L
L
P
F
L
S
S
T
I
S
P
Y
Y
R
Q
S
L
F
R
T
V
L
D
S
G
60
61
I
S
E
V
R
S
D
R
D
K
F
V
I
F
L
D
V
K
H
F
S
P
E
D
L
T
V
K
V
Q
D
D
F
V
E
I
H
G
K
H
N
E
R
Q
D
D
H
G
Y
I
S
R
E
F
H
R
R
Y
R
L
120
121
P
S
N
V
D
Q
S
A
L
S
C
S
L
S
A
D
G
M
L
T
F
C
G
P
K
I
Q
T
G
L
D
A
T
H
A
E
R
A
I
P
V
S
R
E
E
K
P
T
S
A
P
S
S
173
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1450
Peptide:
DFVIFLD
Length:
7
Classification:
Amyloid
Mutation(s):
K70D
Structure(s):
No structures
Protein Information
UniProt ID:
P02489
UniProt Name:
CRYAA_HUMAN
Protein Name:
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
Position:
70-76
Literature
PMID:
18232642
Reference:
Biochemistry. 2008 Mar 4;47(9):2961-7.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
71.43
NuAPRpred:
1.24
Tango:
496.73
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
73.1
Area of the profile Above Threshold (AGGRESCAN):
5.44
Best Energy Score (PASTA 2.0):
-6.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1451 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
F
Y
A
I
A
S
L
F
L
A
G
T
A
F
A
A
P
A
T
S
P
N
G
Y
D
A
C
P
D
G
G
L
I
G
T
P
Q
C
C
S
L
D
L
V
G
V
L
S
G
E
C
S
S
P
S
K
T
P
60
61
N
S
A
K
E
F
Q
E
I
C
A
A
S
G
Q
K
A
R
C
C
F
L
S
E
V
F
T
L
G
A
F
C
Q
K
P
V
G
V
T
A
100
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1451
Peptide:
EFQEICA
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q6YF29
UniProt Name:
Q6YF29_GIBMO
Protein Name:
Hydrophobin 4
Position:
65-71
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
57.14
NuAPRpred:
1.63
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.7
Area of the profile Above Threshold (AGGRESCAN):
0.33
Best Energy Score (PASTA 2.0):
-0.27
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1452 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
F
S
R
V
I
F
C
T
F
L
I
L
P
L
L
A
A
A
T
A
I
P
R
T
N
P
P
A
P
T
C
T
T
G
S
L
Q
C
C
N
S
V
Q
A
A
S
N
P
V
V
G
L
L
A
G
L
L
G
I
60
61
V
L
G
P
I
T
G
Q
V
G
L
T
C
S
P
I
T
V
I
G
V
G
G
T
S
C
S
A
Q
T
V
C
C
N
G
N
S
F
N
G
L
I
V
V
G
C
S
P
V
N
I
S
L
113
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1452
Peptide:
FNGLIVV
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
O60048
UniProt Name:
O60048_PLEOS
Protein Name:
Hydrophobin
Position:
98-104
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
71.43
NuAPRpred:
1.97
Tango:
4.37
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
62.5
Area of the profile Above Threshold (AGGRESCAN):
4.61
Best Energy Score (PASTA 2.0):
-6.74
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1453 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
F
K
Q
A
I
L
V
A
T
T
L
T
T
L
A
V
A
T
P
V
V
D
V
R
R
R
T
D
P
A
S
S
C
S
T
G
T
L
N
C
C
N
S
S
G
T
V
E
D
K
T
I
A
G
L
L
G
I
60
61
L
N
I
V
V
S
D
I
T
A
L
V
G
I
T
C
T
P
I
T
V
V
G
A
G
G
T
S
C
T
S
Q
T
L
C
C
D
N
N
N
F
S
G
L
I
T
L
G
C
I
P
I
N
I
N
L
116
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1453
Peptide:
GILNIVV
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8WZI5
UniProt Name:
Q8WZI5_PLEOS
Protein Name:
Hydrophobin
Position:
59-65
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
71.43
NuAPRpred:
2.13
Tango:
327.41
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
52.3
Area of the profile Above Threshold (AGGRESCAN):
3.87
Best Energy Score (PASTA 2.0):
-8.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1454 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
F
L
A
V
V
S
L
L
A
A
T
A
L
A
L
P
N
A
G
V
V
H
P
T
F
A
S
A
D
K
Y
T
L
Q
Q
A
Q
N
K
C
G
E
H
T
T
L
S
C
C
N
H
V
S
K
V
G
D
T
60
61
T
A
F
N
Y
G
L
L
N
G
L
L
G
N
A
I
S
G
P
E
G
V
G
I
L
S
G
C
Q
K
I
S
V
T
A
L
I
G
V
D
D
L
L
N
K
Q
C
Q
Q
N
V
A
C
C
Q
D
N
K
S
V
120
121
A
T
G
G
L
I
N
I
A
T
P
A
C
V
A
L
D
S
I
I
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1454
Peptide:
GLINIAT
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8J0V5
UniProt Name:
Q8J0V5_ASPFM
Protein Name:
Hydrophobin
Position:
124-130
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
57.14
NuAPRpred:
1.71
Tango:
58.5
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
19.9
Area of the profile Above Threshold (AGGRESCAN):
1.86
Best Energy Score (PASTA 2.0):
-4.68
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1455 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
G
W
E
I
P
E
P
Y
V
W
D
E
S
F
R
V
F
Y
E
Q
L
D
E
E
H
K
K
I
F
K
G
I
F
D
C
I
R
D
N
S
A
P
N
L
A
T
L
V
K
V
T
T
N
H
F
T
H
E
E
A
60
61
M
M
D
A
A
K
Y
S
E
V
V
P
H
K
K
M
H
K
D
F
L
E
K
I
G
G
L
S
A
P
V
D
A
K
N
V
D
Y
C
K
E
W
L
V
N
H
I
K
G
T
D
F
K
Y
K
G
K
L
118
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1455
Peptide:
GLSAPVD
Length:
7
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02247
UniProt Name:
HEMTM_THEHE
Protein Name:
Myohemerythrin (MHr)
Position:
86-92
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
57.14
NuAPRpred:
-0.97
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.5
Area of the profile Above Threshold (AGGRESCAN):
0.54
Best Energy Score (PASTA 2.0):
1.74
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1456 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1456
Peptide:
GNNQQNY
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
7-13
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
14.29
NuAPRpred:
-0.64
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-100.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1457 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
L
V
L
K
R
C
L
L
H
L
A
V
I
G
A
L
L
A
V
G
A
T
K
V
P
R
N
Q
D
W
L
G
V
S
R
Q
L
R
T
K
A
W
N
R
Q
L
Y
P
E
W
T
E
A
Q
R
L
D
C
60
61
W
R
G
G
Q
V
S
L
K
V
S
N
D
G
P
T
L
I
G
A
N
A
S
F
S
I
A
L
N
F
P
G
S
Q
K
V
L
P
D
G
Q
V
I
W
V
N
N
T
I
I
N
G
S
Q
V
W
G
G
Q
P
120
121
V
Y
P
Q
E
T
D
D
A
C
I
F
P
D
G
G
P
C
P
S
G
S
W
S
Q
K
R
S
F
V
Y
V
W
K
T
W
G
Q
Y
W
Q
V
L
G
G
P
V
S
G
L
S
I
G
T
G
R
A
M
L
G
180
181
T
H
T
M
E
V
T
V
Y
H
R
R
G
S
R
S
Y
V
P
L
A
H
S
S
S
A
F
T
I
T
D
Q
V
P
F
S
V
S
V
S
Q
L
R
A
L
D
G
G
N
K
H
F
L
R
N
Q
P
L
T
F
240
241
A
L
Q
L
H
D
P
S
G
Y
L
A
E
A
D
L
S
Y
T
W
D
F
G
D
S
S
G
T
L
I
S
R
A
L
V
V
T
H
T
Y
L
E
P
G
P
V
T
A
Q
V
V
L
Q
A
A
I
P
L
T
S
300
301
C
G
S
S
P
V
P
G
T
T
D
G
H
R
P
T
A
E
A
P
N
T
T
A
G
Q
V
P
T
T
E
V
V
G
T
T
P
G
Q
A
P
T
A
E
P
S
G
T
T
S
V
Q
V
P
T
T
E
V
I
S
360
361
T
A
P
V
Q
M
P
T
A
E
S
T
G
M
T
P
E
K
V
P
V
S
E
V
M
G
T
T
L
A
E
M
S
T
P
E
A
T
G
M
T
P
A
E
V
S
I
V
V
L
S
G
T
T
A
A
Q
V
T
T
420
421
T
E
W
V
E
T
T
A
R
E
L
P
I
P
E
P
E
G
P
D
A
S
S
I
M
S
T
E
S
I
T
G
S
L
G
P
L
L
D
G
T
A
T
L
R
L
V
K
R
Q
V
P
L
D
C
V
L
Y
R
Y
480
481
G
S
F
S
V
T
L
D
I
V
Q
G
I
E
S
A
E
I
L
Q
A
V
P
S
G
E
G
D
A
F
E
L
T
V
S
C
Q
G
G
L
P
K
E
A
C
M
E
I
S
S
P
G
C
Q
P
P
A
Q
R
L
540
541
C
Q
P
V
L
P
S
P
A
C
Q
L
V
L
H
Q
I
L
K
G
G
S
G
T
Y
C
L
N
V
S
L
A
D
T
N
S
L
A
V
V
S
T
Q
L
I
M
P
G
Q
E
A
G
L
G
Q
V
P
L
I
V
600
601
G
I
L
L
V
L
M
A
V
V
L
A
S
L
I
Y
R
R
R
L
M
K
Q
D
F
S
V
P
Q
L
P
H
S
S
S
H
W
L
R
L
P
R
I
F
C
S
C
P
I
G
E
N
S
P
L
L
S
G
Q
Q
660
661
V
661
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1457
Peptide:
GQVIWVN
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P40967
UniProt Name:
PMEL_HUMAN
Protein Name:
Melanocyte protein PMEL (ME20-M)
Position:
100-106
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
57.14
NuAPRpred:
2.0
Tango:
302.57
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.9
Area of the profile Above Threshold (AGGRESCAN):
3.44
Best Energy Score (PASTA 2.0):
-6.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1458 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1458
Peptide:
GTYSFYT
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
PLAS_PHAVU
Protein Name:
Position:
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
42.86
NuAPRpred:
0.21
Tango:
30.26
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
25.7
Area of the profile Above Threshold (AGGRESCAN):
2.48
Best Energy Score (PASTA 2.0):
-2.73
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1459 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
F
A
R
T
S
V
F
I
I
L
A
L
T
A
S
F
V
A
A
V
P
T
T
P
K
P
P
P
P
K
P
L
P
P
K
P
S
P
P
P
S
A
P
V
I
Q
C
N
T
G
P
V
Q
C
C
D
S
V
Q
60
61
N
S
N
D
K
E
I
A
N
L
L
G
F
L
G
I
V
T
G
G
D
E
V
P
I
G
V
T
C
S
P
I
S
V
A
G
G
T
G
S
N
S
C
T
A
Q
P
V
C
C
Q
N
N
T
F
N
G
V
V
A
120
121
I
G
C
N
P
I
N
I
N
K
130
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1459
Peptide:
GVVAIGC
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8WZJ3
UniProt Name:
Q8WZJ3_9AGAR
Protein Name:
Hydrophobin
Position:
117-123
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
71.43
NuAPRpred:
1.88
Tango:
189.9
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
45.3
Area of the profile Above Threshold (AGGRESCAN):
3.42
Best Energy Score (PASTA 2.0):
-5.48
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1460 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1460
Peptide:
IFKINVK
Length:
7
Classification:
Amyloid
Mutation(s):
Q76K, S79V, R80K
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
74-80
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
57.14
NuAPRpred:
1.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.0
Area of the profile Above Threshold (AGGRESCAN):
2.88
Best Energy Score (PASTA 2.0):
-5.48
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1461 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1461
Peptide:
IIHFGSD
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
139-145
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
42.86
NuAPRpred:
0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.5
Area of the profile Above Threshold (AGGRESCAN):
2.57
Best Energy Score (PASTA 2.0):
-4.75
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1462 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1462
Peptide:
KLVFFAE
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
687-693
Literature
PMID:
11076514
Reference:
Biochemistry. 2000 Nov 14;39(45):13748-59.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
71.43
NuAPRpred:
1.39
Tango:
492.6
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
62.7
Area of the profile Above Threshold (AGGRESCAN):
4.76
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1463 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1463
Peptide:
KLVFFAK
Length:
7
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
71.43
NuAPRpred:
1.12
Tango:
482.88
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
66.8
Area of the profile Above Threshold (AGGRESCAN):
5.04
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1464 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1464
Peptide:
KMVLYTL
Length:
7
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
Reference:
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
71.43
NuAPRpred:
0.65
Tango:
277.45
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
63.9
Area of the profile Above Threshold (AGGRESCAN):
4.75
Best Energy Score (PASTA 2.0):
-4.21
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1465 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1465
Peptide:
KNFNYNI
Length:
7
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
WALTZ
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
42.86
NuAPRpred:
0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-22.0
Area of the profile Above Threshold (AGGRESCAN):
0.45
Best Energy Score (PASTA 2.0):
-3.25
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1466 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1466
Peptide:
KNNQKNY
Length:
7
Classification:
Amyloid
Mutation(s):
G7K, Q11K
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
7-13
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
14.29
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-99.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.46
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1467 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
L
V
L
K
R
C
L
L
H
L
A
V
I
G
A
L
L
A
V
G
A
T
K
V
P
R
N
Q
D
W
L
G
V
S
R
Q
L
R
T
K
A
W
N
R
Q
L
Y
P
E
W
T
E
A
Q
R
L
D
C
60
61
W
R
G
G
Q
V
S
L
K
V
S
N
D
G
P
T
L
I
G
A
N
A
S
F
S
I
A
L
N
F
P
G
S
Q
K
V
L
P
D
G
Q
V
I
W
V
N
N
T
I
I
N
G
S
Q
V
W
G
G
Q
P
120
121
V
Y
P
Q
E
T
D
D
A
C
I
F
P
D
G
G
P
C
P
S
G
S
W
S
Q
K
R
S
F
V
Y
V
W
K
T
W
G
Q
Y
W
Q
V
L
G
G
P
V
S
G
L
S
I
G
T
G
R
A
M
L
G
180
181
T
H
T
M
E
V
T
V
Y
H
R
R
G
S
R
S
Y
V
P
L
A
H
S
S
S
A
F
T
I
T
D
Q
V
P
F
S
V
S
V
S
Q
L
R
A
L
D
G
G
N
K
H
F
L
R
N
Q
P
L
T
F
240
241
A
L
Q
L
H
D
P
S
G
Y
L
A
E
A
D
L
S
Y
T
W
D
F
G
D
S
S
G
T
L
I
S
R
A
L
V
V
T
H
T
Y
L
E
P
G
P
V
T
A
Q
V
V
L
Q
A
A
I
P
L
T
S
300
301
C
G
S
S
P
V
P
G
T
T
D
G
H
R
P
T
A
E
A
P
N
T
T
A
G
Q
V
P
T
T
E
V
V
G
T
T
P
G
Q
A
P
T
A
E
P
S
G
T
T
S
V
Q
V
P
T
T
E
V
I
S
360
361
T
A
P
V
Q
M
P
T
A
E
S
T
G
M
T
P
E
K
V
P
V
S
E
V
M
G
T
T
L
A
E
M
S
T
P
E
A
T
G
M
T
P
A
E
V
S
I
V
V
L
S
G
T
T
A
A
Q
V
T
T
420
421
T
E
W
V
E
T
T
A
R
E
L
P
I
P
E
P
E
G
P
D
A
S
S
I
M
S
T
E
S
I
T
G
S
L
G
P
L
L
D
G
T
A
T
L
R
L
V
K
R
Q
V
P
L
D
C
V
L
Y
R
Y
480
481
G
S
F
S
V
T
L
D
I
V
Q
G
I
E
S
A
E
I
L
Q
A
V
P
S
G
E
G
D
A
F
E
L
T
V
S
C
Q
G
G
L
P
K
E
A
C
M
E
I
S
S
P
G
C
Q
P
P
A
Q
R
L
540
541
C
Q
P
V
L
P
S
P
A
C
Q
L
V
L
H
Q
I
L
K
G
G
S
G
T
Y
C
L
N
V
S
L
A
D
T
N
S
L
A
V
V
S
T
Q
L
I
M
P
G
Q
E
A
G
L
G
Q
V
P
L
I
V
600
601
G
I
L
L
V
L
M
A
V
V
L
A
S
L
I
Y
R
R
R
L
M
K
Q
D
F
S
V
P
Q
L
P
H
S
S
S
H
W
L
R
L
P
R
I
F
C
S
C
P
I
G
E
N
S
P
L
L
S
G
Q
Q
660
661
V
661
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1467
Peptide:
LASLIYR
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P40967
UniProt Name:
PMEL_HUMAN
Protein Name:
Melanocyte protein PMEL (ME20-M)
Position:
611-617
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
71.43
NuAPRpred:
0.62
Tango:
56.31
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
48.0
Area of the profile Above Threshold (AGGRESCAN):
3.59
Best Energy Score (PASTA 2.0):
-2.75
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1468 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1468
Peptide:
LKQALKL
Length:
7
Classification:
Amyloid
Mutation(s):
V12K, E13Q, Y16K
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
57.14
NuAPRpred:
-0.14
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.7
Area of the profile Above Threshold (AGGRESCAN):
0.59
Best Energy Score (PASTA 2.0):
0.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1469 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1469
Peptide:
LVEALYL
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
35-41
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
85.71
NuAPRpred:
1.66
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
38.5
Area of the profile Above Threshold (AGGRESCAN):
2.83
Best Energy Score (PASTA 2.0):
-1.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1470 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
Y
W
L
L
A
L
F
V
T
M
W
T
D
V
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
T
W
G
Q
P
H
60
61
G
G
G
W
G
Q
P
H
G
G
S
W
G
Q
P
H
G
G
S
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
N
Q
W
N
K
P
S
K
P
K
T
N
L
K
H
V
A
G
A
A
A
A
G
A
V
120
121
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
M
I
H
F
G
N
D
W
E
D
R
Y
Y
R
E
N
M
Y
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
S
N
Q
N
N
F
V
H
D
C
V
N
180
181
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
V
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
R
S
S
S
T
V
L
F
S
S
P
P
240
241
V
I
L
L
I
S
F
L
I
F
L
I
V
G
254
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1470
Peptide:
MIHFGND
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04925
UniProt Name:
PRIO_MOUSE
Protein Name:
Major prion protein (PrP)
Position:
137-143
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
42.86
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.8
Area of the profile Above Threshold (AGGRESCAN):
1.73
Best Energy Score (PASTA 2.0):
-2.96
Aggregate Orientation (PASTA 2.0):
Parallel
