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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Statistics
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1471 to 1500 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1471
MMHFGND
7
Amyloid
Major prion protein (PrP)
P04273
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
P-1472
MPEEELL
7
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1473
NAPGETY
7
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1474
NFLVHSS
7
Amyloid
Major prion protein (PrP)
P04273
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
P-1475
NHVTLSQ
7
Amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1476
NLSLFDQ
7
Amyloid
Hydrophobin
Q6YF32
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1477
QKLVFFA
7
Non-amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
AmyLoad
P-1478
QQEVINK
7
Amyloid
Chorion protein S36
P07182
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1479
RLVFFAK
7
Amyloid
Amyloid-beta precursor protein (APP)
P05067
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1480
RLVFFAR
7
Amyloid
Amyloid-beta precursor protein (APP)
P05067
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1481
SLLNIVV
7
Amyloid
Hydrophobin
Q8WZI6
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1482
TAFTILA
7
Amyloid
Hydrophobin
Q8WZJ2
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1483
TEAEMKA
7
Non-amyloid
Myoglobin
P02185
No
Protein Sci. 1997 Mar;6(3):706-16.
9070453
AmyLoad
P-1484
TGVTAVA
7
Amyloid
Alpha-synuclein
P37840
No
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1485
TLSIYQY
7
Amyloid
Major curlin subunit (Fimbrin SEF17)
P0A1E7
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1486
TVIAFLA
7
Amyloid
Hydrophobin
Q6YF31
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1487
VGDIVIF
7
Amyloid
chaperonin (GroES protein) (Protein Cpn10)
P0A6F9
No
J Mol Biol. 2008 Apr 11;377(5):1593-606.
18329043
CPAD
P-1488
VKTGVTK
7
Non-amyloid
Alpha-synuclein
P37840
V71K, A76K
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1489
VQIVYKK
7
Amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):191-6.
24367077
AmyLoad
P-1490
VQQNYQA
7
Amyloid
Chorion protein S36
P17110
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1491
VVKGVTK
7
Amyloid
Alpha-synuclein
P37840
T72K, A76K
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1492
VVTGVTA
7
Amyloid
Alpha-synuclein
P37840
No
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-1493
YGNLISL
7
Amyloid
Hydrophobin
Q9P8T0
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1494
AFGAILSS
8
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
N56A
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1495
AGAAAAGA
8
Amyloid
Major prion protein (PrP)
P04273
No
J Mol Biol. 2008 May 16;378(5):1142-54.
18423487
CPAD
P-1496
ANYCNFV
8
Amyloid
Insulin
P01308
Nat Methods. 2010 Mar;7(3):237-42.
20154676
WALTZ
P-1497
CQVNIGNR
8
Amyloid
Transcriptional regulator URE2
P23202
No
Fei L, Perrett S
19258323
CPAD
P-1498
DAAKYSEV
8
Non-amyloid
Myohemerythrin (MHr)
P02247
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
AmyLoad
P-1499
DLSFMKGE
8
Amyloid
J Pept Sci. 2006 Dec;12(12):780-9.
17131290
CPAD
P-1500
FLIFLIVG
8
Amyloid
Major prion protein (PrP)
P04156
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
CPAD, AmyLoad
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Entry: P-1471 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
S
Y
W
L
L
A
L
F
V
A
M
W
T
D
V
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
T
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
N
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
M
M
H
F
G
N
D
W
E
D
R
Y
Y
R
E
N
M
N
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
N
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
I
K
I
M
E
R
V
V
E
Q
M
C
T
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
R
S
S
A
V
L
F
S
S
P
P
240
241
V
I
L
L
I
S
F
L
I
F
L
M
V
G
254
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1471
Peptide:
MMHFGND
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04273
UniProt Name:
PRIO_MESAU
Protein Name:
Major prion protein (PrP)
Position:
138-144
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
42.86
NuAPRpred:
-0.81
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.2
Area of the profile Above Threshold (AGGRESCAN):
0.93
Best Energy Score (PASTA 2.0):
-1.36
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1472 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1472
Peptide:
MPEEELL
Length:
7
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
57-63
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
3
Hydrophobicity:
57.14
NuAPRpred:
-1.12
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-52.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.64
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1473 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1473
Peptide:
NAPGETY
Length:
7
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
64-70
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
42.86
NuAPRpred:
-1.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.43
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1474 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1474
Peptide:
NFLVHSS
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04273
UniProt Name:
IAPP_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
47-53
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
42.86
NuAPRpred:
0.82
Tango:
2.71
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.4
Area of the profile Above Threshold (AGGRESCAN):
2.44
Best Energy Score (PASTA 2.0):
-3.63
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1475 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1475
Peptide:
NHVTLSQ
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
103-109
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
28.57
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.1
Area of the profile Above Threshold (AGGRESCAN):
0.71
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1476 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
Y
M
T
I
V
A
F
L
A
A
T
V
A
A
G
P
Q
I
R
A
Y
P
S
I
D
Q
I
T
V
A
Q
A
N
N
A
C
G
N
N
M
Q
V
T
C
C
N
K
V
T
N
T
P
A
G
N
A
V
G
60
61
N
G
A
G
I
L
N
N
L
S
L
F
D
Q
C
S
K
L
D
V
N
V
L
A
I
A
N
G
L
L
N
K
E
C
Q
A
N
A
A
C
C
Q
N
S
G
G
S
A
T
G
G
L
V
N
V
A
L
P
C
I
120
121
A
L
S
S
L
I
126
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1476
Peptide:
NLSLFDQ
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q6YF32
UniProt Name:
Q6YF32_GIBMO
Protein Name:
Hydrophobin
Position:
68-74
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
42.86
NuAPRpred:
-0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.1
Area of the profile Above Threshold (AGGRESCAN):
1.1
Best Energy Score (PASTA 2.0):
-1.74
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1477 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1477
Peptide:
QKLVFFA
Length:
7
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
686-692
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
71.43
NuAPRpred:
1.18
Tango:
1.36
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
59.7
Area of the profile Above Threshold (AGGRESCAN):
4.61
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1478 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
L
G
L
W
F
G
I
L
A
I
A
A
T
P
L
V
S
A
N
Y
G
P
A
G
G
H
G
H
G
H
G
H
G
Q
Y
L
S
G
P
N
A
G
L
E
E
Y
V
N
V
A
S
G
G
N
Q
Q
A
A
60
61
N
Q
I
A
S
Q
A
E
I
Q
P
T
P
E
E
A
R
R
L
G
R
V
Q
A
Q
L
Q
A
L
N
A
D
P
N
Y
Q
K
L
K
N
S
E
D
I
A
E
S
L
A
E
T
N
L
A
S
N
I
R
Q
G
120
121
K
I
K
V
V
S
P
Q
F
V
D
Q
H
L
F
R
S
L
L
V
P
S
G
H
N
N
H
Q
V
I
A
T
Q
P
L
P
P
I
I
V
H
Q
P
G
A
P
P
A
H
V
N
S
G
P
P
T
V
V
R
G
180
181
N
P
V
I
Y
K
I
K
P
S
V
I
Y
Q
Q
E
V
I
N
K
V
P
T
P
L
S
L
N
P
V
Y
V
K
V
Y
K
P
G
K
K
I
E
A
P
L
A
P
V
V
A
P
V
Y
S
Q
P
R
E
Y
S
240
241
Q
P
Q
G
Y
G
S
A
G
A
A
S
S
A
A
G
A
A
S
S
A
D
G
N
A
Y
G
N
E
A
P
L
Y
N
S
P
A
P
Y
G
Q
P
N
Y
284
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1478
Peptide:
QQEVINK
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P07182
UniProt Name:
CH36_DROME
Protein Name:
Chorion protein S36
Position:
194-200
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
28.57
NuAPRpred:
0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-25.2
Area of the profile Above Threshold (AGGRESCAN):
0.08
Best Energy Score (PASTA 2.0):
-2.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1479 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1479
Peptide:
RLVFFAK
Length:
7
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
71.43
NuAPRpred:
0.35
Tango:
481.85
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
64.2
Area of the profile Above Threshold (AGGRESCAN):
4.83
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1480 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1480
Peptide:
RLVFFAR
Length:
7
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
71.43
NuAPRpred:
-0.42
Tango:
481.79
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
61.5
Area of the profile Above Threshold (AGGRESCAN):
4.64
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1481 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
F
K
Q
A
I
L
V
A
T
T
L
A
T
L
A
V
A
T
P
V
V
D
I
R
R
R
T
D
P
A
S
S
C
T
T
G
T
I
N
C
C
N
S
S
A
A
A
D
D
K
S
I
A
G
L
L
S
L
60
61
L
N
I
V
V
G
D
I
T
A
L
V
G
I
T
C
T
P
I
S
V
G
G
I
G
G
T
S
C
S
S
Q
T
L
C
C
D
N
N
N
F
S
G
L
L
A
L
G
C
I
P
I
N
I
N
L
116
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1481
Peptide:
SLLNIVV
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8WZI6
UniProt Name:
Q8WZI6_PLEOS
Protein Name:
Hydrophobin
Position:
59-65
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
71.43
NuAPRpred:
2.08
Tango:
199.57
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
49.4
Area of the profile Above Threshold (AGGRESCAN):
3.74
Best Energy Score (PASTA 2.0):
-7.47
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1482 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
I
R
V
T
A
F
T
I
L
A
L
T
S
S
F
V
G
A
L
P
S
P
A
A
A
T
I
P
A
S
Q
C
N
T
G
S
L
Q
C
C
Q
T
L
S
N
S
S
N
S
G
V
T
T
L
S
G
L
L
60
61
G
I
V
I
P
A
N
V
P
V
G
L
T
C
N
P
I
S
L
L
V
G
I
G
G
N
S
C
S
A
Q
P
V
C
C
Q
G
N
N
F
N
G
L
I
V
L
G
C
T
P
V
N
L
N
L
115
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1482
Peptide:
TAFTILA
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q8WZJ2
UniProt Name:
Q8WZJ2_9AGAR
Protein Name:
Hydrophobin
Position:
6-12
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
71.43
NuAPRpred:
1.28
Tango:
390.42
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.1
Area of the profile Above Threshold (AGGRESCAN):
3.42
Best Energy Score (PASTA 2.0):
-3.7
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1483 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
L
S
E
G
E
W
Q
L
V
L
H
V
W
A
K
V
E
A
D
V
A
G
H
G
Q
D
I
L
I
R
L
F
K
S
H
P
E
T
L
E
K
F
D
R
F
K
H
L
K
T
E
A
E
M
K
A
S
E
60
61
D
L
K
K
H
G
V
T
V
L
T
A
L
G
A
I
L
K
K
K
G
H
H
E
A
E
L
K
P
L
A
Q
S
H
A
T
K
H
K
I
P
I
K
Y
L
E
F
I
S
E
A
I
I
H
V
L
H
S
R
H
120
121
P
G
D
F
G
A
D
A
Q
G
A
M
N
K
A
L
E
L
F
R
K
D
I
A
A
K
Y
K
E
L
G
Y
Q
G
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1483
Peptide:
TEAEMKA
Length:
7
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02185
UniProt Name:
MYG_PHYMC
Protein Name:
Myoglobin
Position:
52-58
Literature
PMID:
9070453
Reference:
Protein Sci. 1997 Mar;6(3):706-16.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
42.86
NuAPRpred:
-1.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-59.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.14
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1484 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1484
Peptide:
TGVTAVA
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
72-78
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
57.14
NuAPRpred:
0.24
Tango:
25.85
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.0
Area of the profile Above Threshold (AGGRESCAN):
1.44
Best Energy Score (PASTA 2.0):
-3.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1485 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
F
A
A
I
V
V
S
G
S
A
L
A
G
V
V
P
Q
W
G
G
G
G
N
H
N
G
G
G
N
S
S
G
P
D
S
T
L
S
I
Y
Q
Y
G
S
A
N
A
A
L
A
L
Q
60
61
S
D
A
R
K
S
E
T
T
I
T
Q
S
G
Y
G
N
G
A
D
V
G
Q
G
A
D
N
S
T
I
E
L
T
Q
N
G
F
R
N
N
A
T
I
D
Q
W
N
A
K
N
S
D
I
T
V
G
Q
Y
G
G
120
121
N
N
A
A
L
V
N
Q
T
A
S
D
S
S
V
M
V
R
Q
V
G
F
G
N
N
A
T
A
N
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1485
Peptide:
TLSIYQY
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P0A1E7
UniProt Name:
CSGA_SALEN
Protein Name:
Major curlin subunit (Fimbrin SEF17)
Position:
44-50
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
57.14
NuAPRpred:
1.18
Tango:
4.93
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
43.6
Area of the profile Above Threshold (AGGRESCAN):
3.31
Best Energy Score (PASTA 2.0):
-2.58
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1486 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Y
A
Y
T
V
I
A
F
L
A
A
S
V
A
A
A
G
N
G
P
S
I
S
S
L
T
V
Q
Q
A
A
N
S
C
A
N
G
Q
S
V
Y
C
C
N
K
T
S
N
K
P
A
G
N
S
V
G
D
G
A
60
61
G
I
A
N
G
L
S
L
F
S
Q
C
S
K
V
D
V
N
V
I
A
I
A
N
N
L
L
N
K
E
C
Q
A
N
A
A
C
C
Q
D
S
P
G
T
A
A
A
G
L
V
N
A
A
L
P
C
V
A
I
S
120
121
N
L
V
123
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1486
Peptide:
TVIAFLA
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q6YF31
UniProt Name:
Q6YF31_GIBMO
Protein Name:
Hydrophobin
Position:
5-11
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
85.71
NuAPRpred:
1.98
Tango:
493.54
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
67.2
Area of the profile Above Threshold (AGGRESCAN):
5.01
Best Energy Score (PASTA 2.0):
-5.2
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1487 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
N
I
R
P
L
H
D
R
V
I
V
K
R
K
E
V
E
T
K
S
A
G
G
I
V
L
T
G
S
A
A
A
K
S
T
R
G
E
V
L
A
V
G
N
G
R
I
L
E
N
G
E
V
K
P
L
D
V
K
60
61
V
G
D
I
V
I
F
N
D
G
Y
G
V
K
S
E
K
I
D
N
E
E
V
L
I
M
S
E
S
D
I
L
A
I
V
E
A
97
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1487
Peptide:
VGDIVIF
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P0A6F9
UniProt Name:
CH10_ECOLI
Protein Name:
chaperonin (GroES protein) (Protein Cpn10)
Position:
61-67
Literature
PMID:
18329043
Reference:
J Mol Biol. 2008 Apr 11;377(5):1593-606.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
71.43
NuAPRpred:
1.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
60.9
Area of the profile Above Threshold (AGGRESCAN):
4.59
Best Energy Score (PASTA 2.0):
-6.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1488 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1488
Peptide:
VKTGVTK
Length:
7
Classification:
Non-amyloid
Mutation(s):
V71K, A76K
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
70-76
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
28.57
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.5
Area of the profile Above Threshold (AGGRESCAN):
0.33
Best Energy Score (PASTA 2.0):
-1.5
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1489 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1489
Peptide:
VQIVYKK
Length:
7
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
24367077
Reference:
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):191-6.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
57.14
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.0
Area of the profile Above Threshold (AGGRESCAN):
3.2
Best Energy Score (PASTA 2.0):
-4.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1490 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
N
C
F
L
F
T
L
F
F
V
A
A
P
L
A
T
A
S
Y
G
S
S
S
G
G
G
G
G
G
S
S
Y
L
S
S
A
S
S
N
G
L
D
E
L
V
Q
A
A
A
G
G
A
Q
Q
A
G
G
T
I
60
61
T
P
A
N
A
E
I
P
V
S
P
A
E
V
A
R
L
N
Q
V
Q
A
Q
L
Q
A
L
N
S
N
P
V
Y
R
N
L
K
N
S
D
A
I
A
E
S
L
A
E
S
S
L
A
S
K
I
R
Q
G
N
I
120
121
N
I
V
A
P
N
V
I
D
Q
G
V
Y
R
S
L
L
V
P
S
G
Q
N
N
H
Q
V
I
A
T
Q
P
L
P
P
I
I
V
N
Q
P
A
L
P
P
T
Q
I
G
G
G
P
A
A
V
V
K
A
A
P
180
181
V
I
Y
K
I
K
P
S
V
I
Y
Q
Q
E
V
I
N
K
V
P
T
P
L
S
L
N
P
V
Y
V
K
V
Y
K
P
G
K
K
I
D
A
P
L
V
P
G
V
Q
Q
N
Y
Q
A
P
S
Y
G
G
S
S
240
241
Y
S
A
P
A
A
S
Y
E
P
A
P
A
P
S
Y
S
A
A
P
A
Q
S
Y
N
A
A
P
A
P
S
Y
S
A
A
P
A
A
S
Y
G
A
A
P
S
A
S
Y
D
A
A
P
A
A
S
Y
G
A
E
S
300
301
S
Y
G
S
P
Q
S
S
S
S
Y
G
S
A
P
P
A
S
G
Y
320
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1490
Peptide:
VQQNYQA
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P17110
UniProt Name:
CH36_CERCA
Protein Name:
Chorion protein S36
Position:
227-233
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
42.86
NuAPRpred:
-0.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-57.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.55
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1491 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1491
Peptide:
VVKGVTK
Length:
7
Classification:
Amyloid
Mutation(s):
T72K, A76K
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
70-76
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
42.86
NuAPRpred:
0.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.4
Area of the profile Above Threshold (AGGRESCAN):
1.12
Best Energy Score (PASTA 2.0):
-3.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1492 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1492
Peptide:
VVTGVTA
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
70-76
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
57.14
NuAPRpred:
0.59
Tango:
12.79
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.1
Area of the profile Above Threshold (AGGRESCAN):
1.97
Best Energy Score (PASTA 2.0):
-4.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1493 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
S
L
L
S
K
A
V
S
L
A
I
L
V
T
A
V
V
A
S
P
A
G
N
G
V
E
W
S
G
G
G
T
T
T
V
T
V
T
A
S
S
P
T
T
T
V
T
Q
S
Q
C
S
T
G
D
Q
K
C
60
61
C
Q
S
V
Q
N
S
S
A
A
G
V
S
S
L
L
G
L
L
G
I
V
L
S
G
T
D
V
P
V
G
L
T
C
L
P
I
V
G
G
A
C
Q
S
Q
A
V
C
C
T
D
N
S
Y
G
N
L
I
S
L
120
121
G
C
S
P
L
Q
L
127
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1493
Peptide:
YGNLISL
Length:
7
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q9P8T0
UniProt Name:
Q9P8T0_LENED
Protein Name:
Hydrophobin
Position:
114-120
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
57.14
NuAPRpred:
0.98
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
31.8
Area of the profile Above Threshold (AGGRESCAN):
2.7
Best Energy Score (PASTA 2.0):
-2.82
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1494 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1494
Peptide:
AFGAILSS
Length:
8
Classification:
Amyloid
Mutation(s):
N56A
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
57-63
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
62.5
NuAPRpred:
1.59
Tango:
87.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.9
Area of the profile Above Threshold (AGGRESCAN):
3.19
Best Energy Score (PASTA 2.0):
-1.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1495 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
S
Y
W
L
L
A
L
F
V
A
M
W
T
D
V
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
T
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
N
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
M
M
H
F
G
N
D
W
E
D
R
Y
Y
R
E
N
M
N
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
N
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
I
K
I
M
E
R
V
V
E
Q
M
C
T
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
R
S
S
A
V
L
F
S
S
P
P
240
241
V
I
L
L
I
S
F
L
I
F
L
M
V
G
254
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1495
Peptide:
AGAAAAGA
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04273
UniProt Name:
PRIO_MESAU
Protein Name:
Major prion protein (PrP)
Position:
113-120
Literature
PMID:
18423487
Reference:
J Mol Biol. 2008 May 16;378(5):1142-54.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
75.0
NuAPRpred:
-0.75
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.0
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1496 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
W
M
R
L
L
P
L
L
A
L
L
A
L
W
G
P
D
P
A
A
A
F
V
N
Q
H
L
C
G
S
H
L
V
E
A
L
Y
L
V
C
G
E
R
G
F
F
Y
T
P
K
T
R
R
E
A
E
D
60
61
L
Q
V
G
Q
V
E
L
G
G
G
P
G
A
G
S
L
Q
P
L
A
L
E
G
S
L
Q
K
R
G
I
V
E
Q
C
C
T
S
I
C
S
L
Y
Q
L
E
N
Y
C
N
110
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1496
Peptide:
ANYCNFV
Length:
8
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P01308
UniProt Name:
INS_HUMAN
Protein Name:
Insulin
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
WALTZ
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
62.5
NuAPRpred:
1.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.1
Area of the profile Above Threshold (AGGRESCAN):
1.65
Best Energy Score (PASTA 2.0):
-3.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1497 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1497
Peptide:
CQVNIGNR
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
17-24
Literature
PMID:
19258323
Reference:
Fei L, Perrett S
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
37.5
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-22.6
Area of the profile Above Threshold (AGGRESCAN):
0.48
Best Energy Score (PASTA 2.0):
-2.62
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1498 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
G
W
E
I
P
E
P
Y
V
W
D
E
S
F
R
V
F
Y
E
Q
L
D
E
E
H
K
K
I
F
K
G
I
F
D
C
I
R
D
N
S
A
P
N
L
A
T
L
V
K
V
T
T
N
H
F
T
H
E
E
A
60
61
M
M
D
A
A
K
Y
S
E
V
V
P
H
K
K
M
H
K
D
F
L
E
K
I
G
G
L
S
A
P
V
D
A
K
N
V
D
Y
C
K
E
W
L
V
N
H
I
K
G
T
D
F
K
Y
K
G
K
L
118
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1498
Peptide:
DAAKYSEV
Length:
8
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02247
UniProt Name:
HEMTM_THEHE
Protein Name:
Myohemerythrin (MHr)
Position:
63-70
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-1.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.5
Area of the profile Above Threshold (AGGRESCAN):
0.07
Best Energy Score (PASTA 2.0):
-0.99
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1499 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1499
Peptide:
DLSFMKGE
Length:
8
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
17131290
Reference:
J Pept Sci. 2006 Dec;12(12):780-9.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
37.5
NuAPRpred:
-1.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.8
Area of the profile Above Threshold (AGGRESCAN):
1.19
Best Energy Score (PASTA 2.0):
-1.16
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1500 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1500
Peptide:
FLIFLIVG
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
246-254
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
87.5
NuAPRpred:
3.21
Tango:
595.66
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
117.9
Area of the profile Above Threshold (AGGRESCAN):
10.11
Best Energy Score (PASTA 2.0):
-9.24
Aggregate Orientation (PASTA 2.0):
Parallel
