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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1501 to 1530 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1501
FQVNIGNR
8
Amyloid
Transcriptional regulator URE2
P23202
R17F
Fei L, Perrett S
19258323
CPAD
P-1502
GETYVVTL
8
Amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
CPAD, AmyLoad
P-1503
GKVQIVYK
8
Amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
S622K
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
CPAD, AmyLoad
P-1504
GQVEVSKE
8
Non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636-8
K341S, S342K
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
AmyLoad
P-1505
IQVNIGNR
8
Amyloid
Transcriptional regulator URE2
P23202
R17I
Fei L, Perrett S
19258323
CPAD
P-1506
KGAIIGLM
8
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
J Struct Biol. 2010 Jun;170(3):439-50
20188180
CPAD
P-1507
KGGIIGLM
8
Amyloid
Amyloid-beta precursor protein (APP)
P05067
A30G
J Struct Biol. 2010 Jun;170(3):439-50
20188180
CPAD
P-1508
KGIIIGLM
8
Amyloid
Amyloid-beta precursor protein (APP)
P05067
A30I
J Struct Biol. 2010 Jun;170(3):439-50
20188180
CPAD
P-1509
KIVFKNNA
8
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1510
KKGHHEAE
8
Non-amyloid
Myoglobin
P02185
No
Protein Sci. 1997 Mar;6(3):706-16.
9070453
AmyLoad
P-1511
LAIEATPA
8
Non-amyloid
50S ribosomal protein L9 (BL17)
P02417
No
J Mol Biol. 1999 Mar 26;287(2):395-407.
10080901
AmyLoad
P-1512
LEVLLGSG
8
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1513
LQVNIGNR
8
Amyloid
Transcriptional regulator URE2
P23202
R17L
Fei L, Perrett S
19258323
CPAD
P-1514
MQVNIGNR
8
Amyloid
Transcriptional regulator URE2
P23202
R17M
Fei L, Perrett S
19258323
CPAD
P-1515
MVGKVTVN
8
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1516
NAGDVAFV
8
Amyloid
Lactotransferrin (Lactoferrin)
P02788
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1517
NFAAILSS
8
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
G58A
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1518
NFGAALSS
8
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
I60A
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1519
NFGAIASS
8
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
L61A
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1520
NFGAILSS
8
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1521
NFGSVQFV
8
Amyloid
Lactadherin
Q08431
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1522
PKIKAFLA
8
Non-amyloid
Glutathione S-transferase P
P80031
No
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
11370666
AmyLoad
P-1523
SELNIYQY
8
Amyloid
Major curlin subunit
P28307
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1524
SNNFGAIL
8
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1525
SNTFINNA
8
Amyloid
Merozoite surface protein 2 (Fragment)
Q94673
No
J Pept Sci. 2007 Dec;13(12):839-48.
17883245
CPAD
P-1526
TNVGSNTY
8
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1527
VQVNIGNR
8
Amyloid
Transcriptional regulator URE2
P23202
R17V
Fei L, Perrett S
19258323
CPAD
P-1528
YHIRLSFN
8
Amyloid
Beta-lactoglobulin (Beta-LG)
P02755
M163Y
J Mol Biol. 2009 Feb 27;386(3):878-90.
19133274
CPAD
P-1529
ATQRLANFL
9
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Biopolymers. 2015 May;104(3):196-205.
25913357
AmyLoad
P-1530
HQKLVFFAE
9
Non-amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
AmyLoad
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Entry: P-1501 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1501
Peptide:
FQVNIGNR
Length:
8
Classification:
Amyloid
Mutation(s):
R17F
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
17-24
Literature
PMID:
19258323
Reference:
Fei L, Perrett S
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
37.5
NuAPRpred:
0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-14.0
Area of the profile Above Threshold (AGGRESCAN):
0.71
Best Energy Score (PASTA 2.0):
-3.41
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1502 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1502
Peptide:
GETYVVTL
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
67-74
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.7
Tango:
70.67
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.3
Area of the profile Above Threshold (AGGRESCAN):
4.05
Best Energy Score (PASTA 2.0):
-5.36
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1503 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1503
Peptide:
GKVQIVYK
Length:
8
Classification:
Amyloid
Mutation(s):
S622K
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
621-628
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
1.64
Tango:
88.3
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
26.5
Area of the profile Above Threshold (AGGRESCAN):
3.33
Best Energy Score (PASTA 2.0):
-4.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1504 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
180
181
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
240
241
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
300
301
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
360
361
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
420
421
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
441
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1504
Peptide:
GQVEVSKE
Length:
8
Classification:
Non-amyloid
Mutation(s):
K341S, S342K
Structure(s):
No structures
Protein Information
UniProt ID:
P10636-8
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
335-342
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
25.0
NuAPRpred:
-0.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.8
Area of the profile Above Threshold (AGGRESCAN):
0.22
Best Energy Score (PASTA 2.0):
-1.38
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1505 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1505
Peptide:
IQVNIGNR
Length:
8
Classification:
Amyloid
Mutation(s):
R17I
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
17-24
Literature
PMID:
19258323
Reference:
Fei L, Perrett S
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
37.5
NuAPRpred:
0.74
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.5
Area of the profile Above Threshold (AGGRESCAN):
0.73
Best Energy Score (PASTA 2.0):
-4.49
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1506 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1506
Peptide:
KGAIIGLM
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
699-706
Literature
PMID:
20188180
Reference:
J Struct Biol. 2010 Jun;170(3):439-50
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
62.5
NuAPRpred:
1.7
Tango:
87.87
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
42.3
Area of the profile Above Threshold (AGGRESCAN):
4.02
Best Energy Score (PASTA 2.0):
-3.55
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1507 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1507
Peptide:
KGGIIGLM
Length:
8
Classification:
Amyloid
Mutation(s):
A30G
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
699-706
Literature
PMID:
20188180
Reference:
J Struct Biol. 2010 Jun;170(3):439-50
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
1.68
Tango:
10.75
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.0
Area of the profile Above Threshold (AGGRESCAN):
3.72
Best Energy Score (PASTA 2.0):
-3.55
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1508 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1508
Peptide:
KGIIIGLM
Length:
8
Classification:
Amyloid
Mutation(s):
A30I
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
699-706
Literature
PMID:
20188180
Reference:
J Struct Biol. 2010 Jun;170(3):439-50
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
62.5
NuAPRpred:
2.67
Tango:
380.73
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
65.5
Area of the profile Above Threshold (AGGRESCAN):
5.46
Best Energy Score (PASTA 2.0):
-5.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1509 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1509
Peptide:
KIVFKNNA
Length:
8
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
26-33
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.4
Area of the profile Above Threshold (AGGRESCAN):
2.65
Best Energy Score (PASTA 2.0):
-3.53
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1510 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
L
S
E
G
E
W
Q
L
V
L
H
V
W
A
K
V
E
A
D
V
A
G
H
G
Q
D
I
L
I
R
L
F
K
S
H
P
E
T
L
E
K
F
D
R
F
K
H
L
K
T
E
A
E
M
K
A
S
E
60
61
D
L
K
K
H
G
V
T
V
L
T
A
L
G
A
I
L
K
K
K
G
H
H
E
A
E
L
K
P
L
A
Q
S
H
A
T
K
H
K
I
P
I
K
Y
L
E
F
I
S
E
A
I
I
H
V
L
H
S
R
H
120
121
P
G
D
F
G
A
D
A
Q
G
A
M
N
K
A
L
E
L
F
R
K
D
I
A
A
K
Y
K
E
L
G
Y
Q
G
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1510
Peptide:
KKGHHEAE
Length:
8
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02185
UniProt Name:
MYG_PHYMC
Protein Name:
Myoglobin
Position:
79-86
Literature
PMID:
9070453
Reference:
Protein Sci. 1997 Mar;6(3):706-16.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
12.5
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-96.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.35
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1511 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
I
F
L
K
D
V
K
G
K
G
K
K
G
E
I
K
N
V
A
D
G
Y
A
N
N
F
L
F
K
Q
G
L
A
I
E
A
T
P
A
N
L
K
A
L
E
A
Q
K
Q
K
E
Q
R
Q
A
A
E
60
61
E
L
A
N
A
K
K
L
K
E
Q
L
E
K
L
T
V
T
I
P
A
K
A
G
E
G
G
R
L
F
G
S
I
T
S
K
Q
I
A
E
S
L
Q
A
Q
H
G
L
K
L
D
K
R
K
I
E
L
A
D
A
120
121
I
R
A
L
G
Y
T
N
V
P
V
K
L
H
P
E
V
T
A
T
L
K
V
H
V
T
E
Q
K
149
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1511
Peptide:
LAIEATPA
Length:
8
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02417
UniProt Name:
RL9_GEOSE
Protein Name:
50S ribosomal protein L9 (BL17)
Position:
35-42
Literature
PMID:
10080901
Reference:
J Mol Biol. 1999 Mar 26;287(2):395-407.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
75.0
NuAPRpred:
-0.95
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-8.1
Area of the profile Above Threshold (AGGRESCAN):
0.53
Best Energy Score (PASTA 2.0):
0.16
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1512 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1512
Peptide:
LEVLLGSG
Length:
8
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
1-8
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
1.46
Tango:
1.92
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
30.4
Area of the profile Above Threshold (AGGRESCAN):
3.12
Best Energy Score (PASTA 2.0):
-2.18
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1513 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1513
Peptide:
LQVNIGNR
Length:
8
Classification:
Amyloid
Mutation(s):
R17L
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
17-24
Literature
PMID:
19258323
Reference:
Fei L, Perrett S
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
37.5
NuAPRpred:
0.55
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-16.8
Area of the profile Above Threshold (AGGRESCAN):
0.64
Best Energy Score (PASTA 2.0):
-3.28
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1514 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1514
Peptide:
MQVNIGNR
Length:
8
Classification:
Amyloid
Mutation(s):
R17M
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
17-24
Literature
PMID:
19258323
Reference:
Fei L, Perrett S
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
37.5
NuAPRpred:
0.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.3
Area of the profile Above Threshold (AGGRESCAN):
0.54
Best Energy Score (PASTA 2.0):
-2.7
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1515 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1515
Peptide:
MVGKVTVN
Length:
8
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
92-99
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
16.7
Area of the profile Above Threshold (AGGRESCAN):
1.69
Best Energy Score (PASTA 2.0):
-4.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1516 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
V
F
L
V
L
L
F
L
G
A
L
G
L
C
L
A
G
R
R
R
S
V
Q
W
C
A
V
S
Q
P
E
A
T
K
C
F
Q
W
Q
R
N
M
R
K
V
R
G
P
P
V
S
C
I
K
R
D
S
60
61
P
I
Q
C
I
Q
A
I
A
E
N
R
A
D
A
V
T
L
D
G
G
F
I
Y
E
A
G
L
A
P
Y
K
L
R
P
V
A
A
E
V
Y
G
T
E
R
Q
P
R
T
H
Y
Y
A
V
A
V
V
K
K
G
120
121
G
S
F
Q
L
N
E
L
Q
G
L
K
S
C
H
T
G
L
R
R
T
A
G
W
N
V
P
I
G
T
L
R
P
F
L
N
W
T
G
P
P
E
P
I
E
A
A
V
A
R
F
F
S
A
S
C
V
P
G
A
180
181
D
K
G
Q
F
P
N
L
C
R
L
C
A
G
T
G
E
N
K
C
A
F
S
S
Q
E
P
Y
F
S
Y
S
G
A
F
K
C
L
R
D
G
A
G
D
V
A
F
I
R
E
S
T
V
F
E
D
L
S
D
E
240
241
A
E
R
D
E
Y
E
L
L
C
P
D
N
T
R
K
P
V
D
K
F
K
D
C
H
L
A
R
V
P
S
H
A
V
V
A
R
S
V
N
G
K
E
D
A
I
W
N
L
L
R
Q
A
Q
E
K
F
G
K
D
300
301
K
S
P
K
F
Q
L
F
G
S
P
S
G
Q
K
D
L
L
F
K
D
S
A
I
G
F
S
R
V
P
P
R
I
D
S
G
L
Y
L
G
S
G
Y
F
T
A
I
Q
N
L
R
K
S
E
E
E
V
A
A
R
360
361
R
A
R
V
V
W
C
A
V
G
E
Q
E
L
R
K
C
N
Q
W
S
G
L
S
E
G
S
V
T
C
S
S
A
S
T
T
E
D
C
I
A
L
V
L
K
G
E
A
D
A
M
S
L
D
G
G
Y
V
Y
T
420
421
A
G
K
C
G
L
V
P
V
L
A
E
N
Y
K
S
Q
Q
S
S
D
P
D
P
N
C
V
D
R
P
V
E
G
Y
L
A
V
A
V
V
R
R
S
D
T
S
L
T
W
N
S
V
K
G
K
K
S
C
H
T
480
481
A
V
D
R
T
A
G
W
N
I
P
M
G
L
L
F
N
Q
T
G
S
C
K
F
D
E
Y
F
S
Q
S
C
A
P
G
S
D
P
R
S
N
L
C
A
L
C
I
G
D
E
Q
G
E
N
K
C
V
P
N
S
540
541
N
E
R
Y
Y
G
Y
T
G
A
F
R
C
L
A
E
N
A
G
D
V
A
F
V
K
D
V
T
V
L
Q
N
T
D
G
N
N
N
E
A
W
A
K
D
L
K
L
A
D
F
A
L
L
C
L
D
G
K
R
K
600
601
P
V
T
E
A
R
S
C
H
L
A
M
A
P
N
H
A
V
V
S
R
M
D
K
V
E
R
L
K
Q
V
L
L
H
Q
Q
A
K
F
G
R
N
G
S
D
C
P
D
K
F
C
L
F
Q
S
E
T
K
N
L
660
661
L
F
N
D
N
T
E
C
L
A
R
L
H
G
K
T
T
Y
E
K
Y
L
G
P
Q
Y
V
A
G
I
T
N
L
K
K
C
S
T
S
P
L
L
E
A
C
E
F
L
R
K
710
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1516
Peptide:
NAGDVAFV
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02788
UniProt Name:
TRFL_HUMAN
Protein Name:
Lactotransferrin (Lactoferrin)
Position:
557-564
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
62.5
NuAPRpred:
-0.83
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.9
Area of the profile Above Threshold (AGGRESCAN):
2.41
Best Energy Score (PASTA 2.0):
-4.4
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1517 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1517
Peptide:
NFAAILSS
Length:
8
Classification:
Amyloid
Mutation(s):
G58A
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
57-63
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
62.5
NuAPRpred:
1.98
Tango:
335.9
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
32.7
Area of the profile Above Threshold (AGGRESCAN):
3.23
Best Energy Score (PASTA 2.0):
-2.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1518 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1518
Peptide:
NFGAALSS
Length:
8
Classification:
Amyloid
Mutation(s):
I60A
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
57-63
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.59
Tango:
7.14
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.4
Area of the profile Above Threshold (AGGRESCAN):
0.8
Best Energy Score (PASTA 2.0):
0.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1519 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1519
Peptide:
NFGAIASS
Length:
8
Classification:
Amyloid
Mutation(s):
L61A
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
57-63
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.48
Tango:
14.04
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.7
Area of the profile Above Threshold (AGGRESCAN):
1.52
Best Energy Score (PASTA 2.0):
-1.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1520 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1520
Peptide:
NFGAILSS
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
55-62
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
1.49
Tango:
83.09
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
26.4
Area of the profile Above Threshold (AGGRESCAN):
2.93
Best Energy Score (PASTA 2.0):
-1.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1521 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
P
R
P
R
L
L
A
A
L
C
G
A
L
L
C
A
P
S
L
L
V
A
L
D
I
C
S
K
N
P
C
H
N
G
G
L
C
E
E
I
S
Q
E
V
R
G
D
V
F
P
S
Y
T
C
T
C
L
K
G
60
61
Y
A
G
N
H
C
E
T
K
C
V
E
P
L
G
L
E
N
G
N
I
A
N
S
Q
I
A
A
S
S
V
R
V
T
F
L
G
L
Q
H
W
V
P
E
L
A
R
L
N
R
A
G
M
V
N
A
W
T
P
S
120
121
S
N
D
D
N
P
W
I
Q
V
N
L
L
R
R
M
W
V
T
G
V
V
T
Q
G
A
S
R
L
A
S
H
E
Y
L
K
A
F
K
V
A
Y
S
L
N
G
H
E
F
D
F
I
H
D
V
N
K
K
H
K
180
181
E
F
V
G
N
W
N
K
N
A
V
H
V
N
L
F
E
T
P
V
E
A
Q
Y
V
R
L
Y
P
T
S
C
H
T
A
C
T
L
R
F
E
L
L
G
C
E
L
N
G
C
A
N
P
L
G
L
K
N
N
S
240
241
I
P
D
K
Q
I
T
A
S
S
S
Y
K
T
W
G
L
H
L
F
S
W
N
P
S
Y
A
R
L
D
K
Q
G
N
F
N
A
W
V
A
G
S
Y
G
N
D
Q
W
L
Q
V
D
L
G
S
S
K
E
V
T
300
301
G
I
I
T
Q
G
A
R
N
F
G
S
V
Q
F
V
A
S
Y
K
V
A
Y
S
N
D
S
A
N
W
T
E
Y
Q
D
P
R
T
G
S
S
K
I
F
P
G
N
W
D
N
H
S
H
K
K
N
L
F
E
T
360
361
P
I
L
A
R
Y
V
R
I
L
P
V
A
W
H
N
R
I
A
L
R
L
E
L
L
G
C
387
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1521
Peptide:
NFGSVQFV
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q08431
UniProt Name:
MFGM_HUMAN
Protein Name:
Lactadherin
Position:
309-316
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.23
Tango:
3.07
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
21.1
Area of the profile Above Threshold (AGGRESCAN):
2.61
Best Energy Score (PASTA 2.0):
-3.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1522 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
P
P
Y
T
I
T
Y
F
P
V
R
G
R
C
E
A
M
R
M
L
L
A
D
Q
D
Q
S
W
K
E
E
V
V
T
M
E
T
W
P
P
L
K
P
S
C
L
F
R
Q
L
P
K
F
Q
D
G
D
L
T
L
60
61
Y
Q
S
N
A
I
L
R
H
L
G
R
S
F
G
L
Y
G
K
D
Q
K
E
A
A
L
V
D
M
V
N
D
G
V
E
D
L
R
C
K
Y
A
T
L
I
Y
T
N
Y
E
A
G
K
E
K
Y
V
K
E
L
120
121
P
E
H
L
K
P
F
E
T
L
L
S
Q
N
Q
G
G
Q
A
F
V
V
G
S
Q
I
S
F
A
D
Y
N
L
L
D
L
L
R
I
H
Q
V
L
N
P
S
C
L
D
A
F
P
L
L
S
A
Y
V
A
R
180
181
L
S
A
R
P
K
I
K
A
F
L
A
S
P
E
H
V
N
R
P
I
N
G
N
G
K
N
207
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1522
Peptide:
PKIKAFLA
Length:
8
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P80031
UniProt Name:
GSTP1_PIG
Protein Name:
Glutathione S-transferase P
Position:
185-192
Literature
PMID:
11370666
Reference:
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
75.0
NuAPRpred:
-0.32
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
18.4
Area of the profile Above Threshold (AGGRESCAN):
2.45
Best Energy Score (PASTA 2.0):
-1.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1523 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1523
Peptide:
SELNIYQY
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
43-50
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
1.93
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.1
Area of the profile Above Threshold (AGGRESCAN):
1.9
Best Energy Score (PASTA 2.0):
-3.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1524 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1524
Peptide:
SNNFGAIL
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
53-60
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.3
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.4
Area of the profile Above Threshold (AGGRESCAN):
1.92
Best Energy Score (PASTA 2.0):
-1.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1525 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
F
N
I
K
N
E
S
K
Y
S
N
T
F
I
N
N
A
Y
N
M
S
I
R
R
S
M
T
E
S
N
P
P
T
G
A
S
G
S
A
G
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
60
61
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
A
S
G
S
A
G
120
121
S
G
A
D
A
E
R
S
P
S
T
P
A
T
T
T
T
T
T
T
T
N
D
A
E
A
S
T
S
T
S
S
E
N
P
N
H
N
N
A
K
T
N
P
K
G
N
G
G
V
Q
E
P
N
Q
A
176
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1525
Peptide:
SNTFINNA
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q94673
UniProt Name:
Q94673_PLAFA
Protein Name:
Merozoite surface protein 2 (Fragment)
Position:
10-17
Literature
PMID:
17883245
Reference:
J Pept Sci. 2007 Dec;13(12):839-48.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
37.5
NuAPRpred:
0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.7
Area of the profile Above Threshold (AGGRESCAN):
0.96
Best Energy Score (PASTA 2.0):
-2.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1526 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1526
Peptide:
TNVGSNTY
Length:
8
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
63-70
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
25.0
NuAPRpred:
-1.03
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-29.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1527 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
M
N
N
N
G
N
Q
V
S
N
L
S
N
A
L
R
Q
V
N
I
G
N
R
N
S
N
T
T
T
D
Q
S
N
I
N
F
E
F
S
T
G
V
N
N
N
N
N
N
N
S
S
S
N
N
N
N
V
Q
N
60
61
N
N
S
G
R
N
G
S
Q
N
N
D
N
E
N
N
I
K
N
T
L
E
Q
H
R
Q
Q
Q
Q
A
F
S
D
M
S
H
V
E
Y
S
R
I
T
K
F
F
Q
E
Q
P
L
E
G
Y
T
L
F
S
H
R
120
121
S
A
P
N
G
F
K
V
A
I
V
L
S
E
L
G
F
H
Y
N
T
I
F
L
D
F
N
L
G
E
H
R
A
P
E
F
V
S
V
N
P
N
A
R
V
P
A
L
I
D
H
G
M
D
N
L
S
I
W
E
180
181
S
G
A
I
L
L
H
L
V
N
K
Y
Y
K
E
T
G
N
P
L
L
W
S
D
D
L
A
D
Q
S
Q
I
N
A
W
L
F
F
Q
T
S
G
H
A
P
M
I
G
Q
A
L
H
F
R
Y
F
H
S
Q
K
240
241
I
A
S
A
V
E
R
Y
T
D
E
V
R
R
V
Y
G
V
V
E
M
A
L
A
E
R
R
E
A
L
V
M
E
L
D
T
E
N
A
A
A
Y
S
A
G
T
T
P
M
S
Q
S
R
F
F
D
Y
P
V
W
300
301
L
V
G
D
K
L
T
I
A
D
L
A
F
V
P
W
N
N
V
V
D
R
I
G
I
N
I
K
I
E
F
P
E
V
Y
K
W
T
K
H
M
M
R
R
P
A
V
I
K
A
L
R
G
E
354
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1527
Peptide:
VQVNIGNR
Length:
8
Classification:
Amyloid
Mutation(s):
R17V
Structure(s):
No structures
Protein Information
UniProt ID:
P23202
UniProt Name:
URE2_YEAST
Protein Name:
Transcriptional regulator URE2
Position:
17-24
Literature
PMID:
19258323
Reference:
Fei L, Perrett S
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
37.5
NuAPRpred:
0.64
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.2
Area of the profile Above Threshold (AGGRESCAN):
0.68
Best Energy Score (PASTA 2.0):
-4.53
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1528 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
C
L
L
L
A
L
G
L
A
L
A
C
A
A
Q
A
I
I
V
T
Q
T
M
K
G
L
D
I
Q
K
V
A
G
T
W
Y
S
L
A
M
A
A
S
D
I
S
L
L
D
A
Q
S
A
P
L
R
V
Y
60
61
V
E
E
L
K
P
T
P
E
G
D
L
E
I
L
L
Q
K
W
E
N
G
E
C
A
Q
K
K
I
I
A
E
K
T
K
I
P
A
V
F
K
I
D
A
L
N
E
N
K
V
L
V
L
D
T
D
Y
K
K
Y
120
121
L
L
F
C
M
E
N
S
A
E
P
E
Q
S
L
A
C
Q
C
L
V
R
T
P
E
V
D
D
E
A
L
E
K
F
D
K
A
L
K
A
L
P
M
H
I
R
L
S
F
N
P
T
Q
L
E
E
Q
C
H
V
180
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1528
Peptide:
YHIRLSFN
Length:
8
Classification:
Amyloid
Mutation(s):
M163Y
Structure(s):
No structures
Protein Information
UniProt ID:
P02755
UniProt Name:
LACB_BUBBU
Protein Name:
Beta-lactoglobulin (Beta-LG)
Position:
163-170
Literature
PMID:
19133274
Reference:
J Mol Biol. 2009 Feb 27;386(3):878-90.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.75
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.8
Area of the profile Above Threshold (AGGRESCAN):
1.59
Best Energy Score (PASTA 2.0):
-2.23
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1529 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1529
Peptide:
ATQRLANFL
Length:
9
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
41-49
Literature
PMID:
25913357
Reference:
Biopolymers. 2015 May;104(3):196-205.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
55.56
NuAPRpred:
-2.09
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.7
Area of the profile Above Threshold (AGGRESCAN):
1.11
Best Energy Score (PASTA 2.0):
-1.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1530 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1530
Peptide:
HQKLVFFAE
Length:
9
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
685-693
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
55.56
NuAPRpred:
2.37
Tango:
468.73
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
29.0
Area of the profile Above Threshold (AGGRESCAN):
4.15
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
