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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1801 to 1830 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1801
GSTDYGILQINSRWWS
16
Amyloid
Lysozyme C
P00698
C82S
J Mol Biol. 2000 Jul 14;300(3):541-9.
10884350
CPAD, AmyLoad
P-1802
GSTDYGTLQINSRWWS
16
Amyloid
Lysozyme C
P00698
C82S, I73T
J Mol Biol. 2000 Jul 14;300(3):541-9.
10884350
CPAD, AmyLoad
P-1803
IQRTPKIQVYSRHPAE
16
Non-amyloid
Beta-2-microglobulin
P61769
No
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
12488093
AmyLoad
P-1804
LSQTFVYGGSRAKRNN
16
Amyloid
Pancreatic trypsin inhibitor (Aprotinin)
P00974
C65S, C73S
J Mol Biol. 1993 Dec 5;234(3):861-78.
7504737
CPAD, AmyLoad
P-1805
LVEVGGDVQLDSVRIF
16
Amyloid
Galectin-7
P47929
No
J Biol Chem. 2014 Oct 17;289(42):29195-207
25172508
CPAD
P-1806
MDGLELLKTIRADSAY
16
Non-amyloid
Chemotaxis protein CheY
Q93P00
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1807
MSSYAFFVQTCREEHK
16
Amyloid
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
P09429
No
Biochemistry. 2001 Aug 28;40(34):10032-7.
11513581
AmyLoad
P-1808
QGVSFRMYTEDEARKI
16
Non-amyloid
Acylphosphatase-2
P14621
C22S
Nat Struct Biol. 2002 Feb;9(2):137-43.
11799398
AmyLoad
P-1809
VHHQEKLVFFAEDPGS
16
Amyloid
Amyloid-beta precursor protein (APP)
P05067
[del]688E, V695P
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1810
VHHQEKLVFFAEDVPS
16
Amyloid
Amyloid-beta precursor protein (APP)
P05067
[del]688E, G696P
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1811
VHHQEKLVFFAEPVGS
16
Amyloid
Amyloid-beta precursor protein (APP)
P05067
[del]688E, D694P
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1812
VHHQEKLVFFAPDVGS
16
Non-amyloid
Amyloid-beta precursor protein (APP)
P05067
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
AmyLoad
P-1813
VNGMELSKQILQENPH
16
Non-amyloid
Transcriptional regulatory protein ComA (Competence protein A)
P14204
No
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1814
VTNVGGAVVTGVTAVA
16
Amyloid
Alpha-synuclein
P37840
No
Eur J Biochem. 2000 Apr;267(8):2186-94.
10759841
CPAD, AmyLoad
P-1815
YKQQSIQLIEAGVTKR
16
Non-amyloid
Regulatory protein cro (Antirepressor)
P03036
V28Y
Protein Sci. 1999 Aug;8(8):1675-88.
10452612
AmyLoad
P-1816
AKKENIIAAAQAGASGY
17
Amyloid
Chemotaxis protein CheY
P0AE67
No
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
CPAD, AmyLoad
P-1817
AVSVEEGKALAEEEGLF
17
Non-amyloid
Ras-related protein RABA5e (AtRABA5e) (Ras-related protein Ara-1)
P19892
No
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1818
DIKIMERVVEQMCTTQY
17
Amyloid
Major prion protein (PrP)
P04156
V203I, M205I, [del]T216
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1819
GSPSSRIDRTNFSNEKT
17
Non-amyloid
Acylphosphatase-2
P14621
No
Nat Struct Biol. 2002 Feb;9(2):137-43.
11799398
AmyLoad
P-1820
MQTLSERLKKRRIALKY
17
Non-amyloid
Regulatory protein cro (Antirepressor)
P03036
M17Y
Protein Sci. 1999 Aug;8(8):1675-88.
10452612
AmyLoad
P-1821
RLLIVVVVVVLVVVVIV
17
Amyloid
Pulmonary surfactant-associated protein C (SP-C)
P21841
No
Swiss Med Wkly. 2003 May 17;133(19-20):275-82.
12844270
CPAD
P-1822
RLVEVGGDVQLDSVRIF
17
Amyloid
Galectin-7
P47929
No
J Biol Chem. 2014 Oct 17;289(42):29195-207
25172508
CPAD
P-1823
STAQSLKSVDYEVFGRV
17
Non-amyloid
Acylphosphatase-2
P14621
No
Nat Struct Biol. 2002 Feb;9(2):137-43.
11799398
AmyLoad
P-1824
TKRPRFLYEIAMALNSD
17
Amyloid
Regulatory protein cro (Antirepressor)
P03036
F48Y, C56S
Protein Sci. 1999 Aug;8(8):1675-88.
10452612
CPAD, AmyLoad
P-1825
TPANLKALEAQKQKEQR
17
Non-amyloid
50S ribosomal protein L9 (BL17)
P02417
No
J Mol Biol. 1999 Mar 26;287(2):395-407.
10080901
AmyLoad
P-1826
VANAFIICGTLYTVSSY
17
Amyloid
Myocilin
Q99972
No
J Mol Biol. 2014 Feb 20;426(4):921-35
24333014
CPAD
P-1827
YDYQEKSPREVTMKKGD
17
Non-amyloid
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Q13813
No
J Mol Biol. 1996 Jan 26;255(3):507-21.
8568894
AmyLoad
P-1828
YEVHHQKLVFFAEDVGS
17
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1829
AGAVVGGLGGYMLGSAMS
18
Amyloid
Major prion protein (PrP)
P04156
No
J Mol Biol. 1997 Dec 5;274(3):381-93.
9405147
CPAD
P-1830
AVGKSNLLSRYARNEFSA
18
Non-amyloid
Ras-related protein RABA5e (AtRABA5e) (Ras-related protein Ara-1)
P19892
No
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
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Entry: P-1801 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
S
L
L
I
L
V
L
C
F
L
P
L
A
A
L
G
K
V
F
G
R
C
E
L
A
A
A
M
K
R
H
G
L
D
N
Y
R
G
Y
S
L
G
N
W
V
C
A
A
K
F
E
S
N
F
N
T
Q
A
60
61
T
N
R
N
T
D
G
S
T
D
Y
G
I
L
Q
I
N
S
R
W
W
C
N
D
G
R
T
P
G
S
R
N
L
C
N
I
P
C
S
A
L
L
S
S
D
I
T
A
S
V
N
C
A
K
K
I
V
S
D
G
120
121
N
G
M
N
A
W
V
A
W
R
N
R
C
K
G
T
D
V
Q
A
W
I
R
G
C
R
L
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1801
Peptide:
GSTDYGILQINSRWWS
Length:
16
Classification:
Amyloid
Mutation(s):
C82S
Structure(s):
No structures
Protein Information
UniProt ID:
P00698
UniProt Name:
LYSC_CHICK
Protein Name:
Lysozyme C
Position:
67-82
Literature
PMID:
10884350
Reference:
J Mol Biol. 2000 Jul 14;300(3):541-9.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
37.5
NuAPRpred:
0.15
Tango:
1.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-6.1
Area of the profile Above Threshold (AGGRESCAN):
2.45
Best Energy Score (PASTA 2.0):
-3.27
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1802 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
S
L
L
I
L
V
L
C
F
L
P
L
A
A
L
G
K
V
F
G
R
C
E
L
A
A
A
M
K
R
H
G
L
D
N
Y
R
G
Y
S
L
G
N
W
V
C
A
A
K
F
E
S
N
F
N
T
Q
A
60
61
T
N
R
N
T
D
G
S
T
D
Y
G
I
L
Q
I
N
S
R
W
W
C
N
D
G
R
T
P
G
S
R
N
L
C
N
I
P
C
S
A
L
L
S
S
D
I
T
A
S
V
N
C
A
K
K
I
V
S
D
G
120
121
N
G
M
N
A
W
V
A
W
R
N
R
C
K
G
T
D
V
Q
A
W
I
R
G
C
R
L
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1802
Peptide:
GSTDYGTLQINSRWWS
Length:
16
Classification:
Amyloid
Mutation(s):
C82S, I73T
Structure(s):
No structures
Protein Information
UniProt ID:
P00698
UniProt Name:
LYSC_CHICK
Protein Name:
Lysozyme C
Position:
67-82
Literature
PMID:
10884350
Reference:
J Mol Biol. 2000 Jul 14;300(3):541-9.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
31.25
NuAPRpred:
-3.22
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.5
Area of the profile Above Threshold (AGGRESCAN):
0.75
Best Energy Score (PASTA 2.0):
-1.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1803 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1803
Peptide:
IQRTPKIQVYSRHPAE
Length:
16
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
21-36
Literature
PMID:
12488093
Reference:
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
43.75
NuAPRpred:
-5.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.9
Area of the profile Above Threshold (AGGRESCAN):
1.41
Best Energy Score (PASTA 2.0):
-2.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1804 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
M
S
R
L
C
L
S
V
A
L
L
V
L
L
G
T
L
A
A
S
T
P
G
C
D
T
S
N
Q
A
K
A
Q
R
P
D
F
C
L
E
P
P
Y
T
G
P
C
K
A
R
I
I
R
Y
F
Y
N
A
60
61
K
A
G
L
C
Q
T
F
V
Y
G
G
C
R
A
K
R
N
N
F
K
S
A
E
D
C
M
R
T
C
G
G
A
I
G
P
W
E
N
L
100
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1804
Peptide:
LSQTFVYGGSRAKRNN
Length:
16
Classification:
Amyloid
Mutation(s):
C65S, C73S
Structure(s):
No structures
Protein Information
UniProt ID:
P00974
UniProt Name:
BPT1_BOVIN
Protein Name:
Pancreatic trypsin inhibitor (Aprotinin)
Position:
64-79
Literature
PMID:
7504737
Reference:
J Mol Biol. 1993 Dec 5;234(3):861-78.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
3
Absolute Charge:
3
Hydrophobicity:
31.25
NuAPRpred:
-2.52
Tango:
13.52
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.4
Area of the profile Above Threshold (AGGRESCAN):
3.09
Best Energy Score (PASTA 2.0):
-3.41
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1805 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
N
V
P
H
K
S
S
L
P
E
G
I
R
P
G
T
V
L
R
I
R
G
L
V
P
P
N
A
S
R
F
H
V
N
L
L
C
G
E
E
Q
G
S
D
A
A
L
H
F
N
P
R
L
D
T
S
E
V
60
61
V
F
N
S
K
E
Q
G
S
W
G
R
E
E
R
G
P
G
V
P
F
Q
R
G
Q
P
F
E
V
L
I
I
A
S
D
D
G
F
K
A
V
V
G
D
A
Q
Y
H
H
F
R
H
R
L
P
L
A
R
V
R
120
121
L
V
E
V
G
G
D
V
Q
L
D
S
V
R
I
F
136
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1805
Peptide:
LVEVGGDVQLDSVRIF
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P47929
UniProt Name:
LEG7_HUMAN
Protein Name:
Galectin-7
Position:
121-136
Literature
PMID:
25172508
Reference:
J Biol Chem. 2014 Oct 17;289(42):29195-207
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
50.0
NuAPRpred:
-2.27
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.8
Area of the profile Above Threshold (AGGRESCAN):
3.55
Best Energy Score (PASTA 2.0):
-3.62
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1806 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
D
K
E
L
K
F
L
V
V
D
D
F
S
T
M
R
R
I
V
R
N
L
L
K
E
L
G
F
N
N
V
E
E
A
E
D
G
L
D
A
L
N
K
L
Q
A
G
G
Y
G
F
V
I
S
D
W
N
M
60
61
P
N
M
D
G
L
E
L
L
K
T
I
R
A
D
G
A
M
S
A
L
P
V
L
M
V
T
A
E
A
K
K
E
N
I
I
A
A
A
Q
A
G
A
S
G
Y
V
V
K
P
F
T
A
A
T
L
E
E
K
L
120
121
N
K
I
F
E
K
L
G
M
129
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1806
Peptide:
MDGLELLKTIRADSAY
Length:
16
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q93P00
UniProt Name:
CHEY_ECOL6
Protein Name:
Chemotaxis protein CheY
Position:
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
50.0
NuAPRpred:
-2.9
Tango:
2.13
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.9
Area of the profile Above Threshold (AGGRESCAN):
1.82
Best Energy Score (PASTA 2.0):
-2.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1807 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
K
G
D
P
K
K
P
R
G
K
M
S
S
Y
A
F
F
V
Q
T
C
R
E
E
H
K
K
K
H
P
D
A
S
V
N
F
S
E
F
S
K
K
C
S
E
R
W
K
T
M
S
A
K
E
K
G
K
F
60
61
E
D
M
A
K
A
D
K
A
R
Y
E
R
E
M
K
T
Y
I
P
P
K
G
E
T
K
K
K
F
K
D
P
N
A
P
K
R
P
P
S
A
F
F
L
F
C
S
E
Y
R
P
K
I
K
G
E
H
P
G
L
120
121
S
I
G
D
V
A
K
K
L
G
E
M
W
N
N
T
A
A
D
D
K
Q
P
Y
E
K
K
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
R
A
K
G
K
P
D
A
A
K
K
G
V
V
K
A
E
K
180
181
S
K
K
K
K
E
E
E
E
D
E
E
D
E
E
D
E
E
E
E
E
D
E
E
D
E
D
E
E
E
D
D
D
D
E
215
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1807
Peptide:
MSSYAFFVQTCREEHK
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09429
UniProt Name:
HMGB1_HUMAN
Protein Name:
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Position:
13-28
Literature
PMID:
11513581
Reference:
Biochemistry. 2001 Aug 28;40(34):10032-7.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
43.75
NuAPRpred:
2.68
Tango:
439.79
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-7.0
Area of the profile Above Threshold (AGGRESCAN):
5.02
Best Energy Score (PASTA 2.0):
-3.72
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1808 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
T
A
Q
S
L
K
S
V
D
Y
E
V
F
G
R
V
Q
G
V
C
F
R
M
Y
T
E
D
E
A
R
K
I
G
V
V
G
W
V
K
N
T
S
K
G
T
V
T
G
Q
V
Q
G
P
E
D
K
V
N
60
61
S
M
K
S
W
L
S
K
V
G
S
P
S
S
R
I
D
R
T
N
F
S
N
E
K
T
I
S
K
L
E
Y
S
N
F
S
I
R
Y
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1808
Peptide:
QGVSFRMYTEDEARKI
Length:
16
Classification:
Non-amyloid
Mutation(s):
C22S
Structure(s):
No structures
Protein Information
UniProt ID:
P14621
UniProt Name:
ACYP2_HUMAN
Protein Name:
Acylphosphatase-2
Position:
19-34
Literature
PMID:
11799398
Reference:
Nat Struct Biol. 2002 Feb;9(2):137-43.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
6
Hydrophobicity:
37.5
NuAPRpred:
-5.8
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.1
Area of the profile Above Threshold (AGGRESCAN):
2.1
Best Energy Score (PASTA 2.0):
-1.88
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1809 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1809
Peptide:
VHHQEKLVFFAEDPGS
Length:
16
Classification:
Amyloid
Mutation(s):
[del]688E, V695P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
43.75
NuAPRpred:
0.58
Tango:
359.55
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.5
Area of the profile Above Threshold (AGGRESCAN):
3.75
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1810 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1810
Peptide:
VHHQEKLVFFAEDVPS
Length:
16
Classification:
Amyloid
Mutation(s):
[del]688E, G696P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
50.0
NuAPRpred:
0.99
Tango:
365.82
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.4
Area of the profile Above Threshold (AGGRESCAN):
3.79
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1811 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1811
Peptide:
VHHQEKLVFFAEPVGS
Length:
16
Classification:
Amyloid
Mutation(s):
[del]688E, D694P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
0.68
Tango:
432.9
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.1
Area of the profile Above Threshold (AGGRESCAN):
4.39
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1812 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1812
Peptide:
VHHQEKLVFFAPDVGS
Length:
16
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-0.4
Tango:
62.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.7
Area of the profile Above Threshold (AGGRESCAN):
4.18
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1813 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
K
I
L
V
I
D
D
H
P
A
V
M
E
G
T
K
T
I
L
E
T
D
S
N
L
S
V
D
C
L
S
P
E
P
S
E
Q
F
I
K
Q
H
D
F
S
S
Y
D
L
I
L
M
D
L
N
L
G
G
60
61
E
V
N
G
M
E
L
S
K
Q
I
L
Q
E
N
P
H
C
K
I
I
V
Y
T
G
Y
E
V
E
D
Y
F
E
E
A
I
R
A
G
L
H
G
A
I
S
K
T
E
S
K
E
K
I
T
Q
Y
I
Y
H
V
120
121
L
N
G
E
I
L
V
D
F
A
Y
F
K
Q
L
M
T
Q
Q
K
T
K
P
A
P
S
S
Q
K
E
Q
D
V
L
T
P
R
E
C
L
I
L
Q
E
V
E
K
G
F
T
N
Q
E
I
A
D
A
L
H
L
180
181
S
K
R
S
I
E
Y
S
L
T
S
I
F
N
K
L
N
V
G
S
R
T
E
A
V
L
I
A
K
S
D
G
V
L
214
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1813
Peptide:
VNGMELSKQILQENPH
Length:
16
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14204
UniProt Name:
CMPA_BACSU
Protein Name:
Transcriptional regulatory protein ComA (Competence protein A)
Position:
62-77
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
37.5
NuAPRpred:
-2.28
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-31.3
Area of the profile Above Threshold (AGGRESCAN):
0.37
Best Energy Score (PASTA 2.0):
-1.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1814 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1814
Peptide:
VTNVGGAVVTGVTAVA
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
63-78
Literature
PMID:
10759841
Reference:
Eur J Biochem. 2000 Apr;267(8):2186-94.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
56.25
NuAPRpred:
2.29
Tango:
413.3
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.3
Area of the profile Above Threshold (AGGRESCAN):
5.02
Best Energy Score (PASTA 2.0):
-7.24
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1815 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
T
L
S
E
R
L
K
K
R
R
I
A
L
K
M
T
Q
T
E
L
A
T
K
A
G
V
K
Q
Q
S
I
Q
L
I
E
A
G
V
T
K
R
P
R
F
L
F
E
I
A
M
A
L
N
C
D
P
V
W
60
61
L
Q
Y
G
T
K
R
G
K
A
A
71
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1815
Peptide:
YKQQSIQLIEAGVTKR
Length:
16
Classification:
Non-amyloid
Mutation(s):
V28Y
Structure(s):
No structures
Protein Information
UniProt ID:
P03036
UniProt Name:
RCRO_BP434
Protein Name:
Regulatory protein cro (Antirepressor)
Position:
28-43
Literature
PMID:
10452612
Reference:
Protein Sci. 1999 Aug;8(8):1675-88.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
37.5
NuAPRpred:
1.76
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.9
Area of the profile Above Threshold (AGGRESCAN):
2.03
Best Energy Score (PASTA 2.0):
-3.27
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1816 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
D
K
E
L
K
F
L
V
V
D
D
F
S
T
M
R
R
I
V
R
N
L
L
K
E
L
G
F
N
N
V
E
E
A
E
D
G
V
D
A
L
N
K
L
Q
A
G
G
Y
G
F
V
I
S
D
W
N
M
60
61
P
N
M
D
G
L
E
L
L
K
T
I
R
A
D
G
A
M
S
A
L
P
V
L
M
V
T
A
E
A
K
K
E
N
I
I
A
A
A
Q
A
G
A
S
G
Y
V
V
K
P
F
T
A
A
T
L
E
E
K
L
120
121
N
K
I
F
E
K
L
G
M
129
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1816
Peptide:
AKKENIIAAAQAGASGY
Length:
17
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P0AE67
UniProt Name:
CHEY_ECOLI
Protein Name:
Chemotaxis protein CheY
Position:
90-106
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
52.94
NuAPRpred:
-0.83
Tango:
16.11
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.2
Area of the profile Above Threshold (AGGRESCAN):
1.54
Best Energy Score (PASTA 2.0):
-3.42
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1817 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
S
D
D
E
G
R
E
E
Y
L
F
K
I
V
V
I
G
D
S
A
V
G
K
S
N
L
L
S
R
Y
A
R
N
E
F
S
A
N
S
K
A
T
I
G
V
E
F
Q
T
Q
S
M
E
I
E
G
K
E
60
61
V
K
A
Q
I
W
D
T
A
G
Q
E
R
F
R
A
V
T
S
A
Y
Y
R
G
A
V
G
A
L
V
V
Y
D
I
T
R
R
T
T
F
E
S
V
G
R
W
L
D
E
L
K
I
H
S
D
T
T
V
A
R
120
121
M
L
V
G
N
K
C
D
L
E
N
I
R
A
V
S
V
E
E
G
K
A
L
A
E
E
E
G
L
F
F
V
E
T
S
A
L
D
S
T
N
V
K
T
A
F
E
M
V
I
L
D
I
Y
N
N
V
S
R
K
180
181
Q
L
N
S
D
T
Y
K
D
E
L
T
V
N
R
V
S
L
V
K
D
D
N
S
A
S
K
Q
S
S
G
F
S
C
C
S
S
T
218
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1817
Peptide:
AVSVEEGKALAEEEGLF
Length:
17
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P19892
UniProt Name:
RAA5E_ARATH
Protein Name:
Ras-related protein RABA5e (AtRABA5e) (Ras-related protein Ara-1)
Position:
134-150
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
-4
Absolute Charge:
6
Hydrophobicity:
47.06
NuAPRpred:
-3.86
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.1
Area of the profile Above Threshold (AGGRESCAN):
1.09
Best Energy Score (PASTA 2.0):
-2.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1818 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1818
Peptide:
DIKIMERVVEQMCTTQY
Length:
17
Classification:
Amyloid
Mutation(s):
V203I, M205I, [del]T216
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
202-218
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
47.06
NuAPRpred:
-0.85
Tango:
0.98
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.2
Area of the profile Above Threshold (AGGRESCAN):
2.02
Best Energy Score (PASTA 2.0):
-4.43
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1819 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
T
A
Q
S
L
K
S
V
D
Y
E
V
F
G
R
V
Q
G
V
C
F
R
M
Y
T
E
D
E
A
R
K
I
G
V
V
G
W
V
K
N
T
S
K
G
T
V
T
G
Q
V
Q
G
P
E
D
K
V
N
60
61
S
M
K
S
W
L
S
K
V
G
S
P
S
S
R
I
D
R
T
N
F
S
N
E
K
T
I
S
K
L
E
Y
S
N
F
S
I
R
Y
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1819
Peptide:
GSPSSRIDRTNFSNEKT
Length:
17
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14621
UniProt Name:
ACYP2_HUMAN
Protein Name:
Acylphosphatase-2
Position:
70-86
Literature
PMID:
11799398
Reference:
Nat Struct Biol. 2002 Feb;9(2):137-43.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
17.65
NuAPRpred:
-6.4
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-52.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.79
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1820 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
T
L
S
E
R
L
K
K
R
R
I
A
L
K
M
T
Q
T
E
L
A
T
K
A
G
V
K
Q
Q
S
I
Q
L
I
E
A
G
V
T
K
R
P
R
F
L
F
E
I
A
M
A
L
N
C
D
P
V
W
60
61
L
Q
Y
G
T
K
R
G
K
A
A
71
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1820
Peptide:
MQTLSERLKKRRIALKY
Length:
17
Classification:
Non-amyloid
Mutation(s):
M17Y
Structure(s):
No structures
Protein Information
UniProt ID:
P03036
UniProt Name:
RCRO_BP434
Protein Name:
Regulatory protein cro (Antirepressor)
Position:
1-17
Literature
PMID:
10452612
Reference:
Protein Sci. 1999 Aug;8(8):1675-88.
source:
AmyLoad
Derived Information
Net Charge:
5
Absolute Charge:
7
Hydrophobicity:
41.18
NuAPRpred:
-3.12
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-16.6
Area of the profile Above Threshold (AGGRESCAN):
1.45
Best Energy Score (PASTA 2.0):
-1.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1821 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
M
S
S
K
E
V
L
M
E
S
P
P
D
Y
S
A
G
P
R
S
Q
F
R
I
P
C
C
P
V
H
L
K
R
L
L
I
V
V
V
V
V
V
L
V
V
V
V
I
V
G
A
L
L
M
G
L
H
M
60
61
S
Q
K
H
T
E
M
V
L
E
M
S
I
G
A
P
E
T
Q
K
R
L
A
P
S
E
R
A
D
T
I
A
T
F
S
I
G
S
T
G
I
V
V
Y
D
Y
Q
R
L
L
T
A
Y
K
P
A
P
G
T
Y
120
121
C
Y
I
M
K
M
A
P
E
S
I
P
S
L
E
A
F
A
R
K
L
Q
N
F
R
A
K
P
S
T
P
T
S
K
L
G
Q
E
E
G
H
D
T
G
S
E
S
D
S
S
G
R
D
L
A
F
L
G
L
A
180
181
V
S
T
L
C
G
E
L
P
L
Y
Y
I
193
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1821
Peptide:
RLLIVVVVVVLVVVVIV
Length:
17
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P21841
UniProt Name:
PSPC_MOUSE
Protein Name:
Pulmonary surfactant-associated protein C (SP-C)
Position:
35-51
Literature
PMID:
12844270
Reference:
Swiss Med Wkly. 2003 May 17;133(19-20):275-82.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
94.12
NuAPRpred:
12.8
Tango:
1489.37
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
134.7
Area of the profile Above Threshold (AGGRESCAN):
23.42
Best Energy Score (PASTA 2.0):
-28.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1822 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
N
V
P
H
K
S
S
L
P
E
G
I
R
P
G
T
V
L
R
I
R
G
L
V
P
P
N
A
S
R
F
H
V
N
L
L
C
G
E
E
Q
G
S
D
A
A
L
H
F
N
P
R
L
D
T
S
E
V
60
61
V
F
N
S
K
E
Q
G
S
W
G
R
E
E
R
G
P
G
V
P
F
Q
R
G
Q
P
F
E
V
L
I
I
A
S
D
D
G
F
K
A
V
V
G
D
A
Q
Y
H
H
F
R
H
R
L
P
L
A
R
V
R
120
121
L
V
E
V
G
G
D
V
Q
L
D
S
V
R
I
F
136
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1822
Peptide:
RLVEVGGDVQLDSVRIF
Length:
17
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P47929
UniProt Name:
LEG7_HUMAN
Protein Name:
Galectin-7
Position:
120-136
Literature
PMID:
25172508
Reference:
J Biol Chem. 2014 Oct 17;289(42):29195-207
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
47.06
NuAPRpred:
-2.27
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.9
Area of the profile Above Threshold (AGGRESCAN):
3.14
Best Energy Score (PASTA 2.0):
-3.62
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1823 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
T
A
Q
S
L
K
S
V
D
Y
E
V
F
G
R
V
Q
G
V
C
F
R
M
Y
T
E
D
E
A
R
K
I
G
V
V
G
W
V
K
N
T
S
K
G
T
V
T
G
Q
V
Q
G
P
E
D
K
V
N
60
61
S
M
K
S
W
L
S
K
V
G
S
P
S
S
R
I
D
R
T
N
F
S
N
E
K
T
I
S
K
L
E
Y
S
N
F
S
I
R
Y
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1823
Peptide:
STAQSLKSVDYEVFGRV
Length:
17
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14621
UniProt Name:
ACYP2_HUMAN
Protein Name:
Acylphosphatase-2
Position:
2-18
Literature
PMID:
11799398
Reference:
Nat Struct Biol. 2002 Feb;9(2):137-43.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
41.18
NuAPRpred:
-4.22
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.4
Area of the profile Above Threshold (AGGRESCAN):
2.3
Best Energy Score (PASTA 2.0):
-3.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1824 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
T
L
S
E
R
L
K
K
R
R
I
A
L
K
M
T
Q
T
E
L
A
T
K
A
G
V
K
Q
Q
S
I
Q
L
I
E
A
G
V
T
K
R
P
R
F
L
F
E
I
A
M
A
L
N
C
D
P
V
W
60
61
L
Q
Y
G
T
K
R
G
K
A
A
71
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1824
Peptide:
TKRPRFLYEIAMALNSD
Length:
17
Classification:
Amyloid
Mutation(s):
F48Y, C56S
Structure(s):
No structures
Protein Information
UniProt ID:
P03036
UniProt Name:
RCRO_BP434
Protein Name:
Regulatory protein cro (Antirepressor)
Position:
41-57
Literature
PMID:
10452612
Reference:
Protein Sci. 1999 Aug;8(8):1675-88.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
52.94
NuAPRpred:
-1.35
Tango:
10.71
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.4
Area of the profile Above Threshold (AGGRESCAN):
4.52
Best Energy Score (PASTA 2.0):
-2.6
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1825 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
I
F
L
K
D
V
K
G
K
G
K
K
G
E
I
K
N
V
A
D
G
Y
A
N
N
F
L
F
K
Q
G
L
A
I
E
A
T
P
A
N
L
K
A
L
E
A
Q
K
Q
K
E
Q
R
Q
A
A
E
60
61
E
L
A
N
A
K
K
L
K
E
Q
L
E
K
L
T
V
T
I
P
A
K
A
G
E
G
G
R
L
F
G
S
I
T
S
K
Q
I
A
E
S
L
Q
A
Q
H
G
L
K
L
D
K
R
K
I
E
L
A
D
A
120
121
I
R
A
L
G
Y
T
N
V
P
V
K
L
H
P
E
V
T
A
T
L
K
V
H
V
T
E
Q
K
149
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1825
Peptide:
TPANLKALEAQKQKEQR
Length:
17
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02417
UniProt Name:
RL9_GEOSE
Protein Name:
50S ribosomal protein L9 (BL17)
Position:
40-56
Literature
PMID:
10080901
Reference:
J Mol Biol. 1999 Mar 26;287(2):395-407.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
6
Hydrophobicity:
35.29
NuAPRpred:
-4.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.9
Area of the profile Above Threshold (AGGRESCAN):
0.21
Best Energy Score (PASTA 2.0):
-0.06
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1826 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
R
T
A
Q
L
R
K
A
N
D
Q
S
G
R
C
Q
Y
T
F
S
V
A
S
P
N
E
S
S
C
P
E
Q
S
Q
A
M
S
V
I
H
N
L
Q
R
D
S
S
T
Q
R
L
D
L
E
A
T
K
A
R
L
60
61
S
S
L
E
S
L
L
H
Q
L
T
L
D
Q
A
A
R
P
Q
E
T
Q
E
G
L
Q
R
E
L
G
T
L
R
R
E
R
D
Q
L
E
T
Q
T
R
E
L
E
T
A
Y
S
N
L
L
R
D
K
S
V
L
120
121
E
E
E
K
K
R
L
R
Q
E
N
E
N
L
A
R
R
L
E
S
S
S
Q
E
V
A
R
L
R
R
G
Q
C
P
Q
T
R
D
T
A
R
A
V
P
P
G
S
R
E
V
S
T
W
N
L
D
T
L
A
F
180
181
Q
E
L
K
S
E
L
T
E
V
P
A
S
R
I
L
K
E
S
P
S
G
Y
L
R
S
G
E
G
D
T
G
C
G
E
L
V
W
V
G
E
P
L
T
L
R
T
A
E
T
I
T
G
K
Y
G
V
W
M
R
240
241
D
P
K
P
T
Y
P
Y
T
Q
E
T
T
W
R
I
D
T
V
G
T
D
V
R
Q
V
F
E
Y
D
L
I
S
Q
F
M
Q
G
Y
P
S
K
V
H
I
L
P
R
P
L
E
S
T
G
A
V
V
Y
S
G
300
301
S
L
Y
F
Q
G
A
E
S
R
T
V
I
R
Y
E
L
N
T
E
T
V
K
A
E
K
E
I
P
G
A
G
Y
H
G
Q
F
P
Y
S
W
G
G
Y
T
D
I
D
L
A
V
D
E
A
G
L
W
V
I
Y
360
361
S
T
D
E
A
K
G
A
I
V
L
S
K
L
N
P
E
N
L
E
L
E
Q
T
W
E
T
N
I
R
K
Q
S
V
A
N
A
F
I
I
C
G
T
L
Y
T
V
S
S
Y
T
S
A
D
A
T
V
N
F
A
420
421
Y
D
T
G
T
G
I
S
K
T
L
T
I
P
F
K
N
R
Y
K
Y
S
S
M
I
D
Y
N
P
L
E
K
K
L
F
A
W
D
N
L
N
M
V
T
Y
D
I
K
L
S
K
M
472
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1826
Peptide:
VANAFIICGTLYTVSSY
Length:
17
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q99972
UniProt Name:
MYOC_HUMAN
Protein Name:
Myocilin
Position:
394-410
Literature
PMID:
24333014
Reference:
J Mol Biol. 2014 Feb 20;426(4):921-35
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
64.71
NuAPRpred:
7.35
Tango:
875.55
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
48.6
Area of the profile Above Threshold (AGGRESCAN):
9.13
Best Energy Score (PASTA 2.0):
-7.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1827 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
T
G
K
E
L
V
L
A
L
Y
D
Y
Q
E
K
S
P
R
E
V
T
M
K
K
G
D
I
L
T
L
L
N
S
T
N
K
D
W
W
K
V
E
V
N
D
R
Q
G
F
V
P
A
A
Y
V
K
K
L
D
P
60
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1827
Peptide:
YDYQEKSPREVTMKKGD
Length:
17
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13813
UniProt Name:
SPTN1_HUMAN (SH3)
Protein Name:
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Position:
10-26
Literature
PMID:
8568894
Reference:
J Mol Biol. 1996 Jan 26;255(3):507-21.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
8
Hydrophobicity:
29.41
NuAPRpred:
-5.75
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-53.1
Area of the profile Above Threshold (AGGRESCAN):
0.14
Best Energy Score (PASTA 2.0):
-2.38
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1828 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1828
Peptide:
YEVHHQKLVFFAEDVGS
Length:
17
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
681-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
47.06
NuAPRpred:
1.69
Tango:
431.03
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.2
Area of the profile Above Threshold (AGGRESCAN):
3.82
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1829 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1829
Peptide:
AGAVVGGLGGYMLGSAMS
Length:
18
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
118-135
Literature
PMID:
9405147
Reference:
J Mol Biol. 1997 Dec 5;274(3):381-93.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
55.56
NuAPRpred:
-1.04
Tango:
3.14
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.6
Area of the profile Above Threshold (AGGRESCAN):
5.27
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1830 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
S
D
D
E
G
R
E
E
Y
L
F
K
I
V
V
I
G
D
S
A
V
G
K
S
N
L
L
S
R
Y
A
R
N
E
F
S
A
N
S
K
A
T
I
G
V
E
F
Q
T
Q
S
M
E
I
E
G
K
E
60
61
V
K
A
Q
I
W
D
T
A
G
Q
E
R
F
R
A
V
T
S
A
Y
Y
R
G
A
V
G
A
L
V
V
Y
D
I
T
R
R
T
T
F
E
S
V
G
R
W
L
D
E
L
K
I
H
S
D
T
T
V
A
R
120
121
M
L
V
G
N
K
C
D
L
E
N
I
R
A
V
S
V
E
E
G
K
A
L
A
E
E
E
G
L
F
F
V
E
T
S
A
L
D
S
T
N
V
K
T
A
F
E
M
V
I
L
D
I
Y
N
N
V
S
R
K
180
181
Q
L
N
S
D
T
Y
K
D
E
L
T
V
N
R
V
S
L
V
K
D
D
N
S
A
S
K
Q
S
S
G
F
S
C
C
S
S
T
218
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1830
Peptide:
AVGKSNLLSRYARNEFSA
Length:
18
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P19892
UniProt Name:
RAA5E_ARATH
Protein Name:
Ras-related protein RABA5e (AtRABA5e) (Ras-related protein Ara-1)
Position:
22-39
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
44.44
NuAPRpred:
-5.93
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-19.3
Area of the profile Above Threshold (AGGRESCAN):
0.98
Best Energy Score (PASTA 2.0):
-0.83
Aggregate Orientation (PASTA 2.0):
Parallel
